Current Projects

BioStruct-X

BioStruct-X

Project type: Integrated Infrastructure Initiative (I3), (Grant agreement no: 283570)
Funding organisation: EC, FP7
Project duration: September 2011 – February 2016
Web page: www.biostruct-x.eu
EMBL faculty:
EMBL Hamburg: Dmitri Svergun (coordinator), Matthias Wilmanns, Thomas Schneider, Victor Lamzin, Rob Meijers, Jochen Müller-Dieckmann
EMBL Grenoble: Stephen Cusack, Darren Hart, Imre Berger, Jose Marquez, Andrew McCarthy, Florent Cipriani
Project aim: The overall objectives of BioStruct-X are:

  • To provide supported transnational access (TNA) to researchers across Europe, based upon scientific excellence of the projects proposed, to leading research services in X-ray based structural biology, including protein production, HTP crystallisation and structural biology-oriented synchrotron radiation beamlines, with applications in macromolecular X-ray crystallography (MX), small angle X-ray scattering (SAXS) and X-ray imaging (XI).
  • To encourage combined and hybrid approaches in structural biology, using facilities from multiple sites, thus enforcing a future concept of integrated structural cell biology.
  • To reinforce TNA to these facilities and to promote the future availability of emerging facilities (XFEL) by an ambitious focused R&D programme, via four joint research activities (JRAs).
  • To provide broad user training and dissemination of new scientific advances via a programme involving both specific TNA facility partners dedicated to these activities and decentralized socalled TID centres at non-facility sites.
  • To liaise with relevant communities, specifically INSTRUCT, other relevant I3 projects, ESUO, and industrial communities.
  • To enforce the goals by the establishment of an efficient and transparent management structure.

Past Projects

P-CUBE

P-CUBE

Project type: I3 Research Infrastructures
Funding organisation: EC, FP7
Project duration: April 2009 – March 2013
Web page: /www.p-cube.eu
EMBL faculty:
EMBL Hamburg: Matthias Wilmanns, Jochen Mueller-Dieckmann
EMBL Heidelberg: Christoph Müller
EMBL Grenoble: Stephen Cusack, Darren Hart, Imre Berger
Project aim: P-CUBE (Infrastructure for Protein Production Platforms) is the first project within the Seventh Framework Program of the EU that brings together research, networking and service activities. The program offers exciting cutting edge technologies in contemporary structural biology and provides a more general access to European users to the most advanced techniques in cloning, expression, protein characterisation and crystallisation free of charge. It is also the philosophy of P-CUBE to share expertise between the different partner laboratories in order to improve technologies and standardize procedures, with the ultimate aim of disseminating this expertise throughout Europe. World leading European experts in the field of protein expression and production technologies from the University of Zurich, the University of Oxford and the European Molecular Biology Lab share expertise, equipment and their know-how to applicants to ensure smooth workflow.

3D Repertoire

3D Repertoire

Project type: Integrated project (LSHG-CT-2005-512028)
Funding organisation: EC, FP6
Project duration: February 2005 – August 2009 (Extended until January 2010)
Web page: www.3drepertoire.org

EMBL faculty:
EMBL Heidelberg: Bettina Böttcher, Peer Bork, Elena Conti, Anne-Claude Gavin, Rob Russell, Michael Sattler, Klaus Scheffzek, Dietrich Suck, Christoph Müller
EMBL Hamburg: Matthias Wilmanns, Young-Hwa Song
EMBL Grenoble: Darren Hart
Project aim: This project is bringing together the top European structural biology institutions in an unprecedented collaboration to solve the structure of a maximum number of real protein complexes in yeast.

BioXHit

BioXHit

Project type: Integrated project (LHSG-CT-2003-503420)
Funding organisation: EC, FP6
Project duration: January 2004 – December 2007 (Extended until June 2008)
EMBL faculty:
EMBL Hamburg: Victor Lamzin (coordinator), Manfred Weiss (research director), Wolfram Meyer-Klaucke, Andrea Schmidt, Paul Tucker
EMBL Grenoble: Andrew McCarthy, Florent Cipriani, Josán Márquez
Project aim: To mobilise European synchrotron facilities with beamlines equipped for macromolecular crystallography, either already in existence or planned for the future; to engage most of the software developers active in fields relevant to high-throughput structure determination.

For further information on project results and highlights please go to www.bioxhit.org.

ELISA

ELISA

Project type: Integrated Infrastructure Initiative (I3) (Grant agreement nr. 226716)
Funding organisation: EC, FP7
Project duration: March 2009 – August 2011
Web page: www.elettra.eu/ELISA/
EMBL faculty:
EMBL Hamburg: Matthias Wilmanns, Paul Tucker
EMBL Grenoble: Stephen Cusack, Hassan Belrhali
Project aim: The initiative has two strategic objectives:

  • to support transnational users of national facilities in the domain of synchrotron and FEL science;
  • to support joint research activities (JRAs) with the purpose of
    a) enhancing the effectiveness of the facilities in serving users and in particular transnational users, and
    b) contributing to the development of novel sources in this domain.

i3 IA-SFS

i3 IA-SFS

Project type: Integrated Infrastructure Initiative (I3) (RII3-CT-2004-506008)
Funding organisation: EC, FP6
Project duration: March 2004 – February 2009
Web page: www.elettra.trieste.it/i3/
EMBL faculty:
EMBL Hamburg: Matthias Wilmanns, Paul Tucker
EMBL Grenoble: Stephen Cusack, Hassan Belrhali
Project aim: The initiative has two strategic objectives:

  •  to support transnational users of national facilities in the domain of synchrotron and FEL science;
  •  to support joint research activities (JRAs) with the purpose of
    a) enhancing the effectiveness of the facilities in serving users and in particular transnational users, and
    b) contributing to the development of novel sources in this domain.

INSTRUCT

INSTRUCT

Project type: Integrated project (INFRA-2007-2.2.1.19)
Funding organisation: EC, FP7
Project duration: September 2007 - April 2010
Web page: www.instruct-fp7.eu
EMBL faculty:
EMBL Grenoble: Stephen Cusack, Imre Berger
EMBL Hamburg: Matthias Wilmanns
EMBL Heidelberg: Christoph Müller, Peer Bork
Project aim: The aim is to provide a broad range of integrated structural biology infrastructures with particular expertise in synchrotron X-ray and imaging technologies. This initiative builds on existing and planned infrastructure in Europe for protein structure determination, of which there are two main techniques, X-ray crystallography and NMR spectroscopy.

SAXIER

SAXIER

Project type: Design Study (RIDS-011934)
Funding organisation: EC, FP6
Project duration: December 2005 – November 2009
Web page: www.saxier.org
EMBL faculty: Dmitri Svergun (Co-ordinator), Manfred Roessle
Project aim: To develop novel hardware and software for bio- and nanotechnology applications of the high brilliance synchrotron small-angle X-ray scattering beamlines.

SPINE 2 Complexes

SPINE 2 Complexes

Project type: Integrated project (LSHG-CT-2006-031220)
Funding organisation: EC, FP6
Project duration: July 2006 - June 2010
Web page: www.spine2.eu
EMBL faculty:
EMBL Hamburg: Matthias Wilmanns, Arie Geerlof, Young-Hwa Song, Dmitri Svergun, Jochen Müller-Dieckmann
EMBL Grenoble: Stephen Cusack, Darren Hart
Project aim: To determine structures of protein complexes from signaling pathways involved in human health and disease; to develop new technologies for the production and structure determination of these complexes.

Vizier

Vizier

Project type: Integrated project (LSHG-CT-2004-511960)
Funding organisation: EC, Framework VI
Project duration: November 2004 – October 2008 (Extended until April 2009)
Web page: www.vizier-europe.org
EMBL faculty: Paul Tucker
Project aim: To identify potential new drug targets against RNA viruses through comprehensive structural characterization of the replicative machinery of a carefully selected and diverse set of viruses.