Publications

Total: 17 publication(s)

2018

Garcia-Alai MM, Heidemann J, Skruzny M, Gieras A, Mertens HDT, Svergun DI, Kaksonen M, Uetrecht C, Meijers R. (2018)

Epsin and Sla2 form assemblies through phospholipid interfaces.

Nat Commun 9(1) doi: 10.1038/s41467-017-02443-x
Europe PMC | doi

Molina IG, Josts I, Almeida Hernandez Y, Esperante S, Salgueiro M, Garcia Alai MM, de Prat-Gay G, Tidow H. (2018)

Structure and stability of the Human respiratory syncytial virus M2-1 RNA-binding core domain reveals a compact and cooperative folding unit.

Acta Crystallogr F Struct Biol Commun 74(Pt 1):23-30. doi: 10.1107/S2053230X17017381
Europe PMC | doi


2014

Andersen JL, Schrøder TJ, Christensen S, Strandbygård D, Pallesen LT, García-Alai MM, Lindberg S, Langgård M, Eskildsen JC, David L, Tagmose L, Simonsen KB, Maltas PJ, Rønn LC, de Jong IE, Malik IJ, Egebjerg J, Karlsson JJ, Uppalanchi S, Sakumudi DR, Eradi P, Watson SP, Thirup S. (2014)

Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.

Acta Crystallogr D Biol Crystallogr 70(Pt 2):451-60. doi: 10.1107/S1399004713030149
Europe PMC | doi


2010

Nguyen DP, Garcia Alai MM, Virdee S, Chin JW. (2010)

Genetically directing ɛ-N, N-dimethyl-L-lysine in recombinant histones.

Chem Biol 17(10):1072-6. doi: 10.1016/j.chembiol.2010.07.013
Europe PMC | doi

García-Alai MM, Allen MD, Joerger AC, Bycroft M. (2010)

The structure of the FYR domain of transforming growth factor beta regulator 1.

Protein Sci 19(7):1432-8. doi: 10.1002/pro.404
Europe PMC | doi

Neumann H, Wang K, Davis L, Garcia-Alai M, Chin JW. (2010)

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.

Nature 464(7287):441-4. doi: 10.1038/nature08817
Europe PMC | doi


2009

Smal C, Wetzler DE, Dantur KI, Chemes LB, Garcia-Alai MM, Dellarole M, Alonso LG, Gaston K, de Prat-Gay G. (2009)

The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely tuned system for modulating available E7 and E2 proteins.

Biochemistry 48(50):11939-49. doi: 10.1021/bi901415k
Europe PMC | doi

Nguyen DP, Garcia Alai MM, Kapadnis PB, Neumann H, Chin JW. (2009)

Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones.

J Am Chem Soc 131(40):14194-5. doi: 10.1021/ja906603s
Europe PMC | doi


2008

García-Alai MM, Tidow H, Natan E, Townsley FM, Veprintsev DB, Fersht AR. (2008)

The novel p53 isoform "delta p53" is a misfolded protein and does not bind the p21 promoter site.

Protein Sci 17(10):1671-8. doi: 10.1110/ps.036996.108
Europe PMC | doi


2007

García-Alai MM, Alonso LG, de Prat-Gay G. (2007)

The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein.

Biochemistry 46(37):10405-12. doi: 10.1021/bi7007917
Europe PMC | doi

García-Alai MM, Dantur KI, Smal C, Pietrasanta L, de Prat-Gay G. (2007)

High-risk HPV E6 oncoproteins assemble into large oligomers that allow localization of endogenous species in prototypic HPV-transformed cell lines.

Biochemistry 46(2):341-9. doi: 10.1021/bi602457q
Europe PMC | doi


2006

García-Alai MM, Gallo M, Salame M, Wetzler DE, McBride AA, Paci M, Cicero DO, de Prat-Gay G. (2006)

Molecular basis for phosphorylation-dependent, PEST-mediated protein turnover.

Structure 14(2):309-19. doi: 10.1016/j.str.2005.11.012
Europe PMC | doi

Alonso LG, Smal C, Garcia-Alai MM, Chemes L, Salame M, de Prat-Gay G. (2006)

Chaperone holdase activity of human papillomavirus E7 oncoprotein.

Biochemistry 45(3):657-67. doi: 10.1021/bi0522549
Europe PMC | doi


2004

Penrose KJ, Garcia-Alai M, de Prat-Gay G, McBride AA. (2004)

Casein Kinase II phosphorylation-induced conformational switch triggers degradation of the papillomavirus E2 protein.

J Biol Chem 279(21):22430-9. doi: 10.1074/jbc.M314340200
Europe PMC | doi

Alonso LG, García-Alai MM, Smal C, Centeno JM, Iacono R, Castaño E, Gualfetti P, de Prat-Gay G. (2004)

The HPV16 E7 viral oncoprotein self-assembles into defined spherical oligomers.

Biochemistry 43(12):3310-7. doi: 10.1021/bi036037o
Europe PMC | doi


2002

Alonso LG, García-Alai MM, Nadra AD, Lapeña AN, Almeida FL, Gualfetti P, Prat-Gay GD. (2002)

High-risk (HPV16) human papillomavirus E7 oncoprotein is highly stable and extended, with conformational transitions that could explain its multiple cellular binding partners.

Biochemistry 41(33):10510-8. doi: 10.1021/bi025579n
Europe PMC | doi

Padula P, Della Valle MG, Alai MG, Cortada P, Villagra M, Gianella A. (2002)

Andes virus and first case report of Bermejo virus causing fatal pulmonary syndrome.

Emerg Infect Dis 8(4):437-9. doi: 10.3201/eid0804.010300
Europe PMC | doi