EMBL Hamburg c/o DESY, Notkestraße 85, 22607 Hamburg, Germany

E-mail: Send a mail


  • PhD 2008, Department of Physics at the University of Halle-Wittenberg.
    Postdoctoral researcher at the Karolinska Institutet.
    Group leader at EMBL Hamburg since 2014.


Total: 33 publication(s)


Frauenfeld J, Löving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegerschöld C, Flayhan A, Briggs JA, Garoff H, Löw C, Cheng Y, Nordlund P. (2016)

A saposin-lipoprotein nanoparticle system for membrane proteins.

Nat. Methods 13(4):345-351. doi:10.1038/nmeth.3801
Europe PMC | doi

Quistgaard EM, Löw C, Guettou F, Nordlund P. (2016)

Understanding transport by the major facilitator superfamily (MFS): structures pave the way.

Nat Rev Mol Cell Biol 17(2):123-32. doi:10.1038/nrm.2015.25
Europe PMC | doi


Guettou F, Quistgaard EM, Raba M, Moberg P, Löw C, Nordlund P. (2014)

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.

Nat. Struct. Mol. Biol. 21(8):728-731. doi:10.1038/nsmb.2860
Europe PMC | doi

Dovega R, Tsutakawa S, Quistgaard EM, Anandapadamanaban M, Löw C, Nordlund P. (2014)

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

PLoS ONE 9(7):e101846. doi:10.1371/journal.pone.0101846
Europe PMC | doi

Löw C, Quistgaard EM, Kovermann M, Anandapadamanaban M, Balbach J, Nordlund P. (2014)

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A

Biol. Chem. 395(7-8):881-889. doi:10.1515/hsz-2014-0106
Europe PMC | doi


Quistgaard EM, Löw C, Moberg P, Nordlund P. (2013)

Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms

J. Struct. Biol. 184(2):375-378. doi:10.1016/j.jsb.2013.09.009
Europe PMC | doi

Guettou F, Quistgaard EM, Trésaugues L, Moberg P, Jegerschöld C, Zhu L, Jong AJ, Nordlund P, Löw C. (2013)

Structural insights into substrate recognition in proton-dependent oligopeptide transporters

EMBO Rep. 14(9):804-810. doi:10.1038/embor.2013.107
Europe PMC | doi

Quistgaard EM, Löw C, Moberg P, Guettou F, Maddi K, Nordlund P. (2013)

Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31

PLoS ONE 8(8):e71111. doi:10.1371/journal.pone.0071111
Europe PMC | doi

Weininger U, Respondek M, Löw C, Akke M. (2013)

Slow aromatic ring flips detected despite near-degenerate NMR frequencies of the exchanging nuclei

J Phys Chem B 117(31):9241-9247. doi:10.1021/jp4058065
Europe PMC | doi

Löw C, Moberg P, Quistgaard EM, Hedrén M, Guettou F, Frauenfeld J, Haneskog L, Nordlund P. (2013)

High-throughput analytical gel filtration screening of integral membrane proteins for structural studies

Biochim. Biophys. Acta 1830(6):3497-3508. doi:10.1016/j.bbagen.2013.02.001
Europe PMC | doi

Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P. (2013)

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

Nat. Struct. Mol. Biol. 20(6):766-768. doi:10.1038/nsmb.2569
Europe PMC | doi

Guettou F, Löw C, Quistgard E, Hedrén M, Frauenfeld J, Nordlund P, Haneskog L, Moberg P. (2013)

Rapid screening of integral membrane proteins – detergents suitable for structure determination

Discovery Matters (16)

Löw C, Yau YH, Pardon E, Jegerschöld C, Wåhlin L, Quistgaard EM, Moberg P, Geifman-Shochat S, Steyaert J, Nordlund P. (2013)

Nanobody mediated crystallization of an archeal mechanosensitive channel

PLoS ONE 8(10):e77984. doi:10.1371/journal.pone.0077984
Europe PMC | doi


Quistgaard EM, Nordlund P, Löw C. (2012)

High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA

FASEB J. 26(10):4003-4013. doi:10.1096/fj.12-208397
Europe PMC | doi

Löw C, Stubbs MT, Haupt C, Balbach J. (2012)

Metallochaperone SlyD

In: Scott RA (ed.), Encyclopedia of Inorganic and Bioinorganic Chemistry. John Wiley & Sons, Ltd, Hoboken. doi:10.1002/9781119951438.eibc2061

Löw C, Jegerschöld C, Kovermann M, Moberg P, Nordlund P. (2012)

Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1

PLoS ONE 7(6):e38244. doi:10.1371/journal.pone.0038244
Europe PMC | doi


Klepsch MM, Kovermann M, Löw C, Balbach J, Permentier HP, Fusetti F, de Gier JW, Slotboom DJ, Berntsson RP. (2011)

Escherichia coli peptide binding protein OppA has a preference for positively charged peptides

J. Mol. Biol. 414(1):75-85. doi:10.1016/j.jmb.2011.09.043
Europe PMC | doi

Kahra D, Kovermann M, Löw C, Hirschfeld V, Haupt C, Balbach J, Hübner CG. (2011)

Conformational plasticity and dynamics in the generic protein folding catalyst SlyD unraveled by single-molecule FRET

J. Mol. Biol. 411(4):781-790. doi:10.1016/j.jmb.2011.05.002
Europe PMC | doi

Kovermann M, Zierold R, Haupt C, Löw C, Balbach J. (2011)

NMR relaxation unravels interdomain crosstalk of the two domain prolyl isomerase and chaperone SlyD

Biochim. Biophys. Acta 1814(7):873-881. doi:10.1016/j.bbapap.2011.03.016
Europe PMC | doi

Moberg P, Burstedt M, Nordlund P, Haneskog L, Löw C. (2011)

Stability of membrane proteins analyzed by gel filtration

Discovery Matters (13)

Löw C, Hedrén M, Nordlund P, Haneskog L, Moberg P. (2011)

Rapid buffer scouting and quality control of integral membrane proteins

Discovery Matters (12):10-11.


Loew C, Nordlund P. (2010)

Structural studies of the human tetraspan vesicle membrane proteins

FEBS J 277:226-227.

Löw C, Neumann P, Tidow H, Weininger U, Haupt C, Friedrich-Epler B, Scholz C, Stubbs MT, Balbach J. (2010)

Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus

J. Mol. Biol. 398(3):375-390. doi:10.1016/j.jmb.2010.03.014
Europe PMC | doi


Löw C. (2009)

Energy Landscapes of Protein Folding: From Structure to Function

SVH Verlag, Saarbrücken.

Weininger U, Zeeb M, Neumann P, Löw C, Stubbs MT, Lipps G, Balbach J. (2009)

Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus

Biochemistry 48(42):10030-10037. doi:10.1021/bi900760n
Europe PMC | doi

Schulenburg C, Löw C, Weininger U, Mrestani-Klaus C, Hofmann H, Balbach J, Ulbrich-Hofmann R, Arnold U. (2009)

The folding pathway of onconase is directed by a conserved intermediate

Biochemistry 48(35):8449-8457. doi:10.1021/bi900596j
Europe PMC | doi

Hofmann H, Weininger U, Löw C, Golbik RP, Balbach J, Ulbrich-Hofmann R. (2009)

Fast amide proton exchange reveals close relation between native-state dynamics and unfolding kinetics

J. Am. Chem. Soc. 131(1):140-146. doi:10.1021/ja8048942
Europe PMC | doi

Löw C, Homeyer N, Weininger U, Sticht H, Balbach J. (2009)

Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between the native and partially folded state

ACS Chem. Biol. 4(1):53-63. doi:10.1021/cb800219m
Europe PMC | doi


Löw C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J. (2008)

Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers

Biophys. J. 95(9):4315-4323. doi:10.1529/biophysj.108.134155
Europe PMC | doi

Löw C, Weininger U, Neumann P, Klepsch M, Lilie H, Stubbs MT, Balbach J. (2008)

Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein

Proc. Natl. Acad. Sci. U.S.A. 105(10):3779-3784. doi:10.1073/pnas.0710657105
Europe PMC | doi


Schulenburg C, Martinez-Senac MM, Löw C, Golbik R, Ulbrich-Hofmann R, Arnold U. (2007)

Identification of three phases in Onconase refolding

FEBS J. 274(22):5826-5833. doi:10.1111/j.1742-4658.2007.06106.x
Europe PMC | doi

Löw C, Weininger U, Zeeb M, Zhang W, Laue ED, Schmid FX, Balbach J. (2007)

Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d)

J. Mol. Biol. 373(1):219-231. doi:10.1016/j.jmb.2007.07.063
Europe PMC | doi


Zeeb M, Max KE, Weininger U, Löw C, Sticht H, Balbach J. (2006)

Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution

Nucleic Acids Res. 34(16):4561-4571. doi:10.1093/nar/gkl376
Europe PMC | doi