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Staff at EMBL

Dr. Rob Meijers

Group Leader
Meijers Group

EMBL Hamburg c/o DESY, Notkestraße 85, 22603 Hamburg, Germany

E-mail: send a mail

Biography

PhD 2001, EMBL Hamburg/University of Amsterdam.
Postdoctoral research at the Dana Farber Cancer Institute, Boston.
Staff scientist at the Synchrotron Soleil, Saint Aubin, France, 2006-2009.
Group leader at EMBL Hamburg since 2009.

Publications

The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor. Dunne, M., Mertens, H.D., Garefalaki, V., Jeffries, C.M., Thompson, A., Lemke, E.A., Svergun, D.I., Mayer, M.J., Narbad, A. & Meijers, R. PLoS Pathog. 2014 Jul 24;10(7):e1004228. doi: 10.1371/journal.ppat.1004228.eCollection 2014 Jul. Europe PMC

Optimization of protein purification and characterization using Thermofluor screens. Boivin, S., Kozak, S. & Meijers, R. Protein Expr Purif. 2013 Oct;91(2):192-206. doi: 10.1016/j.pep.2013.08.002. Epub2013 Aug 12. Europe PMC

Structure-based modification of a Clostridium difficile-targeting endolysin affects activity and host range. Mayer, M.J., Garefalaki, V., Spoerl, R., Narbad, A. & Meijers, R. J Bacteriol. 2011 Oct;193(19):5477-86. doi: 10.1128/JB.00439-11. Epub 2011 Jul29. Europe PMC

Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Grotenbreg, G.M., Roan, N.R., Guillen, E., Meijers, R., Wang, J.H., Bell, G.W., Starnbach, M.N. & Ploegh, H.L. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3831-6. Epub 2008 Feb 1. Europe PMC

Structural basis of Dscam isoform specificity. Meijers, R., Puettmann-Holgado, R., Skiniotis, G., Liu, J.H., Walz, T., Wang, J.H. & Schmucker, D. Nature. 2007 Sep 27;449(7161):487-91. Epub 2007 Aug 26. Europe PMC

Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase. Meijers, R., Adolph, H.W., Dauter, Z., Wilson, K.S., Lamzin, V.S. & Cedergren-Zeppezauer, E.S. Biochemistry. 2007 May 8;46(18):5446-54. Epub 2007 Apr 13. Europe PMC

Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance. Meijers, R., Lai, C.C., Yang, Y., Liu, J.H., Zhong, W., Wang, J.H. & Reinherz, E.L. J Mol Biol. 2005 Feb 4;345(5):1099-110. Epub 2004 Dec 8. Europe PMC

The crystal structure of glutamyl endopeptidase from Bacillus intermedius reveals a structural link between zymogen activation and charge compensation. Meijers, R., Blagova, E.V., Levdikov, V.M., Rudenskaya, G.N., Chestukhina, G.G., Akimkina, T.V., Kostrov, S.V., Lamzin, V.S. & Kuranova, I.P. Biochemistry 2004 Mar 16;43(10):2784-91. Europe PMC

Zn-dependent medium-chain dehydrogenases/reductases. Meijers, R. & Cedergen-Zeppezauer, E.S. Handbook of Metalloproteins 3 (2004), pp 5-33 editors: Albrecht Messerschmidt, Wolfram Bode, Mirek Cygler, John Wiley & Sons, Ltd, Chichester.

Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family. Tan, K., Zelus, B.D., Meijers, R., Liu, J.H., Bergelson, J.M., Duke, N., Zhang, R., Joachimiak, A., Holmes, K.V. & Wang, J.H. EMBO J. 2002 May 1;21(9):2076-86. Europe PMC

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Wang, J.H., Meijers, R., Xiong, Y., Liu, J.H., Sakihama, T., Zhang, R., Joachimiak, A. & Reinherz, E.L. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10799-804. Epub 2001 Sep 4. Europe PMC

On the enzymatic activation of NADH. Meijers, R., Morris, R.J., Adolph, H.W., Merli, A., Lamzin, V.S. & Cedergren-Zeppezauer, E.S. J Biol Chem 2001 Mar 23;276(12):9316-21. Europe PMC

Structural basis for substrate specificity differences of horse liver alcohol dehydrogenase isozymes. Adolph, H.W., Zwart, P., Meijers, R., Hubatsch, I., Kiefer, M., Lamzin, V. & Cedergren-Zeppezauer, E. Biochemistry 2000 Oct 24;39(42):12885-97 Europe PMC

A preliminary analysis of the three-dimensional structure of dimeric di-haem split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774 at 2.5-Å resolution using the MAD phasing method: a novel cytochrome fold with a stacked-haem arrangement. Matias, P.M., Morais, J., Coelho, A.V., Meijers, R., Gonzalez, A., Thompson, A.W., Sieker, L., LeGall, J. & Carrondo, M.A. JBIC 1997 Aug; 2(4):507-514.