One gene, two proteins, one complex

Hamburg, 15 January 2016

In a study published in the Journal of Biological Chemistry, Meijers and collaborators from the Institute of Food Research in Norwich, UK, show that the genes of viral enzymes that degrade the cell walls of Clostridia bacteria produce not the usual one, but two proteins. The results give insights into how these enzymes degrade the bacterial cell wall, and could be used to combat a range of Clostridium infections. more

Source Article

Dunne M et al. Journal of Biological Chemistry, 18 December 2015. DOI: 10.1074/jbc.M115.671172

How to make a protein happy

Hamburg, 4th February 2016

Protein screens developed at EMBL Hamburg are now commercially available. Stephane Boivin, a staff scientist who initiated the project, tells more about the RUBIC Buffer and Additive Screens, and the journey from idea to commercial product. more

The curious case of the bi-specific enzyme

Hamburg, 18 June 2015

As a chemist with no expertise in protein crystalisation Andrea Rentmeister turned to the Sample Preparation and Characterisation (SPC) facility at EMBL Hamburg for help to learn more about an enzyme with curious bi-specific properties. What started out as a shot in the dark, resulted in a crystal structure – shedding light onto this peculiar feature. more

Source Article

Kaljunen H et al. Angewandte Chemie, 11 June 2015. DOI: 10.1002/ange.201503275

International connections

Hamburg, 8 August 2014

Through a collaboration spanning several years, three continents and several close calls with airport security, Rob Meijers, group leader from EMBL Hamburg, and collaborators have determined the structure of an unusual protein complex that plays an important role in guiding neurons. more

Source Article

Finci, L.I., et al. Published online in Neuron, 7 August 2014. DOI: 10.1016/j.neuron.2014.07.010

Fighting bacteria - with viruses

Hamburg, 24 July 2014

Scientists show how bacteriophages destroy Clostridium difficile cells, opening up new possibilities for using viruses as an alternative to antibiotics. more

Source Article

Dunne, M., et al. PLoS Pathogens, 24 July 2014. DOI: 10.1371/journal.ppat.1004228