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Staff at EMBL

Dr. Thomas Schneider

Group Leader
Schneider (Thomas) Group

EMBL Hamburg c/o DESY, Notkestraße 85, 22603 Hamburg, Germany

E-mail: send a mail

Biography

PhD 1996, Technical University of Munich/EMBL.
Postdoctoral research at the MPI for Molecular Physiology, Dortmund, and the University of Göttingen.
Group leader at the FIRC Institute of Molecular Oncology, Milan.
Group leader at EMBL since 2007. Coordinator MX@PETRA3

Publications

A novel beta-xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds. Espina, G., Eley, K., Pompidor, G., Schneider, T.R., Crennell, S.J. & Danson, M.J. Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1366-74. doi:10.1107/S1399004714002788. Epub 2014 Apr 30. Europe PMC

Serial crystallography on in vivo grown microcrystals using synchrotron radiation. Gati, C., Bourenkov, G., Klinge, M., Rehders, D., Stellato, F., Oberthur, D., Yefanov, O., Sommer, B. P., Mogk, S., Duszenko, M., Betzel, C., Schneider, T. R., Chapman, H. N. & Redecke, L. IUCrJ 2014 1 87-94

SCEDS: protein fragments for molecular replacement in Phaser. McCoy, A.J., Nicholls, R.A. & Schneider, T.R. Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2216-25. doi:10.1107/S0907444913021811. Epub 2013 Oct 4. Europe PMC

Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency. Correia, B., Cerqueira, S.A., Beauchemin, C., Pires de Miranda, M., Li, S., Ponnusamy, R., Rodrigues, L., Schneider, T.R., Carrondo, M.A., Kaye, K.M., Simas, J.P. & McVey, C.E. PLoS Pathog. 2013;9(10):e1003673. doi: 10.1371/journal.ppat.1003673. Epub 2013Oct 17. Europe PMC

Synchrotron radiation: micrometer-sized x-ray beams as fine tools for macromolecular crystallography. Schneider, T.R. HFSP J. 2008 Dec;2(6):302-6. Epub 2008 Oct 17. Europe PMC

RAPIDO: a web server for the alignment of protein structures in the presence of conformational changes. Mosca, R. & Schneider, T.R. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W42-6. Epub 2008 May 6. Europe PMC

Alignment of protein structures in the presence of domain motions. Mosca, R., Brannetti, B. & Schneider, T.R. BMC Bioinformatics. 2008 Aug 27;9:352. Europe PMC

The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop. Biadene, M., Hazemann, I., Cousido, A., Ginell, S., Joachimiak, A., Sheldrick, G.M., Podjarny, A. & Schneider, T.R. Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):665-72. Epub 2007May 15. Europe PMC

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Penengo, L., Mapelli, M., Murachelli, A.G., Confalonieri, S., Magri, L., Musacchio, A., Di Fiore, P.P., Polo, S. & Schneider, T.R. Cell. 2006 Mar 24;124(6):1183-95. Epub 2006 Feb 23. Europe PMC

Substructure determination in isomorphous replacement and anomalous diffraction experiments. Grosse-Kunstleve, R.W. & Schneider, T.R. Methods Mol Biol. 2006;364:197-214. Europe PMC

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L.B., Schneider, T.R., Stukenberg, P.T. & Musacchio, A. Mol Cell. 2005 Apr 29;18(3):379-91. Europe PMC

Domain identification by iterative analysis of error-scaled difference distance matrices. Schneider, T.R. Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2269-75. Epub2004 Nov 26. Europe PMC

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate. Wilmouth, R.C., Edman, K., Neutze, R., Wright, P.A., Clifton, I.J., Schneider, T.R., Schofield, C.J. & Hajdu, J. Nat Struct Biol 2001 Aug;8(8):689-94. Europe PMC

Ab initio structure determination of the lantibiotic mersacidin. Schneider, T.R., Karcher, J., Pohl, E., Lubini, P. & Sheldrick, G.M. Acta Crystallogr D Biol Crystallogr 2000 Jun;56 ( Pt 6):705-13 Europe PMC

1.7 A structure of the stabilized REIv mutant T39K. Application of local NCS restraints. Uson, I., Pohl, E., Schneider, T.R., Dauter, Z., Schmidt, A., Fritz, H.J. & Sheldrick, G.M. Acta Crystallogr D Biol Crystallogr. 1999 Jun;55(Pt 6):1158-67. Europe PMC

Influence of internal dynamics on accuracy of protein NMR structures: derivation of realistic model distance data from a long molecular dynamics trajectory. Schneider, T.R., Brunger, A.T. & Nilges, M. J Mol Biol 1999 Jan 15 285(2) 727-740 Europe PMC

Refinement of triclinic hen egg-white lysozyme at atomic resolution. Walsh, M.A., Schneider, T.R., Sieker, L.C., Dauter, Z., Lamzin, V.S. & Wilson, K.S. Acta Crystallogr D Biol Crystallogr 1998 Jul 1 54 ( Pt 4) 522-546 Europe PMC