EMBL Hamburg c/o DESY, Notkestraße 85, 22607 Hamburg, Germany

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  • PhD 1996, Technical University of Munich/EMBL.
    Postdoctoral research at the MPI for Molecular Physiology, Dortmund, and the University of Göttingen.
    Group leader at the FIRC Institute of Molecular Oncology, Milan.
    Group leader at EMBL since 2007. Coordinator MX@PETRA3.
    Senior scientist since 2015.


Total: 66 publication(s)


McCoy AJ, Schneider T. (2016)

Advances in experimental phasing.

In: Acta Crystallogr D Struct Biol, 2015 CCP4 Study Weekend on Advances in Experimental Phasing, vol 72. pp 291-292. Acta Crystallogr D Struct Biol 72(Pt 3):291-292. doi:10.1107/s2059798316003375
Europe PMC | doi


Lundholm IV, Rodilla H, Wahlgren WY, Duelli A, Bourenkov G, Vukusic J, Friedman R, Stake J, Schneider T, Katona G. (2015)

Terahertz radiation induces non-thermal structural changes associated with Fröhlich condensation in a protein crystal.

Struct Dyn 2(5) doi:10.1063/1.4931825
Europe PMC | doi

Schürmann M, Meijers R, Schneider TR, Steinbüchel A, Cianci M. (2015)

3-Sulfinopropionyl-coenzyme A (3SP-CoA) desulfinase from Advenella mimigardefordensis DPN7(T): crystal structure and function of a desulfinase with an acyl-CoA dehydrogenase fold.

Acta Crystallogr. D Biol. Crystallogr. 71(Pt 6):1360-1372. doi:10.1107/S1399004715006616
Europe PMC | doi


Espina G, Eley K, Pompidor G, Schneider TR, Crennell SJ, Danson MJ. (2014)

A novel β-xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds

Acta Crystallogr. D Biol. Crystallogr. 70D(Pt 5):1366-1374. doi:10.1107/s1399004714002788
Europe PMC | doi

Gati C, Bourenkov G, Klinge M, Rehders D, Stellato F, Oberthur D, Yefanov O, Sommer BP, Mogk S, Duszenko M, Betzel C, Schneider TR, Chapman HN, Redecke L. (2014)

Serial crystallography on in vivo grown microcrystals using synchrotron radiation

IUCrJ 1(Pt 2):87-94. doi:10.1107/s2052252513033939
Europe PMC | doi


McCoy AJ, Nicholls RA, Schneider TR. (2013)

SCEDS: protein fragments for molecular replacement in Phaser

Acta Crystallogr. D Biol. Crystallogr. 69(Pt 11):2216-2225. doi:10.1107/s0907444913021811
Europe PMC | doi

Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE. (2013)

Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency

PLoS Pathog. 9(10):e1003673. doi:10.1371/journal.ppat.1003673
Europe PMC | doi


Schneider TR. (2008)

Synchrotron radiation: micrometer-sized x-ray beams as fine tools for macromolecular crystallography

HFSP J 2(6):302-306. doi:10.2976/1.2982661
Europe PMC | doi

Mosca R, Schneider TR. (2008)

RAPIDO: a web server for the alignment of protein structures in the presence of conformational changes

Nucleic Acids Res. 36(Web Server issue):W42-6. doi:10.1093/nar/gkn197
Europe PMC | doi

Mosca R, Brannetti B, Schneider TR. (2008)

Alignment of protein structures in the presence of domain motions

BMC Bioinformatics 9:352. doi:10.1186/1471-2105-9-352
Europe PMC | doi


Biadene M, Hazemann I, Cousido A, Ginell S, Joachimiak A, Sheldrick GM, Podjarny A, Schneider TR. (2007)

The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop

Acta Crystallogr. D Biol. Crystallogr. 63(Pt 6):665-672. doi:10.1107/s0907444907011997
Europe PMC | doi

Grosse-Kunstleve RW, Schneider TR. (2007)

Substructure determination in isomorphous replacement and anomalous diffraction experiments.

Methods Mol. Biol. 364:197-214. doi:10.1385/1-59745-266-1:197
Europe PMC | doi


Petrova T, Ginell S, Mitschler A, Hazemann I, Schneider T, Cousido A, Lunin VY, Joachimiak A, Podjarny A. (2006)

Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat.

Acta Crystallogr D 62:1535-1544. doi:10.1107/S0907444906041035

Dall'Antonia F, Schneider TR. (2006)

SITCOM: a program for comparing sites in macromolecular substructures.

J Appl Crystallogr 39:618-619. doi:10.1107/S0021889806014518

Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR. (2006)

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

Cell 124(6):1183-1195. doi:10.1016/j.cell.2006.02.020
Europe PMC | doi


Krätzner R, Debreczeni JE, Pape T, Schneider TR, Wentzel A, Kolmar H, Sheldrick GM, Uson I. (2005)

Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold.

Acta Crystallogr. D Biol. Crystallogr. 61(Pt 9):1255-1262. doi:10.1107/S0907444905021207
Europe PMC | doi

Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A. (2005)

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin

Mol. Cell 18(3):379-391. doi:10.1016/j.molcel.2005.03.031
Europe PMC | doi


Schneider TR. (2004)

Domain identification by iterative analysis of error-scaled difference distance matrices

Acta Crystallogr. D Biol. Crystallogr. 60(Pt 12 Pt 1):2269-2275. doi:10.1107/s0907444904023492
Europe PMC | doi

Pape T, Schneider TR. (2004)

HKL2MAP: a graphical user interface for macromolecular phasing with SHELX programs.

J Appl Crystallogr 37:843-844. doi:10.1107/S0021889804018047

Ruiz F, Hazemann I, Mitschler A, Joachimiak A, Schneider T, Karplus M, Podjarny A. (2004)

The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.

Acta Crystallogr. D Biol. Crystallogr. 60(Pt 8):1347-1354. doi:10.1107/s0907444904011370
Europe PMC | doi

Mol CD, Dougan DR, Schneider TR, Skene RJ, Kraus ML, Scheibe DN, Snell GP, Zou H, Sang BC, Wilson KP. (2004)

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.

J. Biol. Chem. 279(30):31655-31663. doi:10.1074/jbc.m403319200
Europe PMC | doi

El-Kabbani O, Darmanin C, Schneider TR, Hazemann I, Ruiz F, Oka M, Joachimiak A, Schulze-Briese C, Tomizaki T, Mitschler A, Podjarny A. (2004)

Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors.

Proteins 55(4):805-813. doi:10.1002/prot.20001
Europe PMC | doi

Howard EI, Sanishvili R, Cachau RE, Mitschler A, Chevrier B, Barth P, Lamour V, Van Zandt M, Sibley E, Bon C, Moras D, Schneider TR, Joachimiak A, Podjarny A. (2004)

Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A.

Proteins 55(4):792-804. doi:10.1002/prot.20015
Europe PMC | doi

Podjarny A, Cachau RE, Schneider T, Van Zandt M, Joachimiak A. (2004)

Subatomic and atomic crystallographic studies of aldose reductase: implications for inhibitor binding.

Cell. Mol. Life Sci. 61(7-8):763-773. doi:10.1007/s00018-003-3401-4
Europe PMC | doi

König V, Pfeil A, Braus GH, Schneider TR. (2004)

Substrate and metal complexes of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae provide new insights into the catalytic mechanism.

J. Mol. Biol. 337(3):675-690. doi:10.1016/j.jmb.2004.01.055
Europe PMC | doi

Bento I, Matias PM, Baptista AM, da Costa PN, van Dongen WM, Saraiva LM, Schneider TR, Soares CM, Carrondo MA. (2004)

Molecular basis for redox-Bohr and cooperative effects in cytochrome c3 from Desulfovibrio desulfuricans ATCC 27774: crystallographic and modeling studies of oxidized and reduced high-resolution structures at pH 7.6.

Proteins 54(1):135-152. doi:10.1002/prot.10431
Europe PMC | doi


Dall'Antonia F, Baker PJ, Schneider TR. (2003)

Optimization of selenium substructures as obtained from SHELXD.

Acta Crystallogr. D Biol. Crystallogr. 59(Pt 11):1987-1994. doi:10.1107/s0907444903017670
Europe PMC | doi

König V, Vértesy L, Schneider TR. (2003)

Structure of the alpha-amylase inhibitor tendamistat at 0.93 A.

Acta Crystallogr. D Biol. Crystallogr. 59(Pt 10):1737-1743. doi:10.1107/s0907444903015828
Europe PMC | doi

Hartmann M, Schneider TR, Pfeil A, Heinrich G, Lipscomb WN, Braus GH. (2003)

Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation.

Proc. Natl. Acad. Sci. U.S.A. 100(3):862-867. doi:10.1073/pnas.0337566100
Europe PMC | doi

Rudolph MG, Kelker MS, Schneider TR, Yeates TO, Oseroff V, Heidary DK, Jennings PA, Wilson IA. (2003)

Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta.

Acta Crystallogr. D Biol. Crystallogr. 59(Pt 2):290-298. doi:10.1107/s0907444902021704
Europe PMC | doi

Mernyak E, Wolfling J, Bunkoczi G, Luo LF, Schneider TR, Schneider G. (2003)

Stereoselective synthesis of the two trans-(16-hydroxymethyl)-3-methoxy-13 alpha-estra-1,3,5(10)-trien-17-ol isomers.

Collect. Czech Chem Commun 68:1141-1148. doi:10.1135/cccc20031141

Podjarny A, Schneider TR, Cachau RE, Joachimiak A. (2003)

Structural information content at high resolution: MAD versus native.

Meth. Enzymol. 374:321-341. doi:10.1016/s0076-6879(03)74015-4
Europe PMC | doi

Weeks CM, Adams PD, Berendzen J, Brunger AT, Dodson EJ, Grosse-Kunstleve RW, Schneider TR, Sheldrick GM, Terwilliger TC, Turkenburg MG, Usón I. (2003)

Automatic solution of heavy-atom substructures.

Meth. Enzymol. 374:37-83. doi:10.1016/s0076-6879(03)74003-8
Europe PMC | doi


Schneider TR, Sheldrick GM. (2002)

Substructure solution with SHELXD.

Acta Crystallogr. D Biol. Crystallogr. 58(Pt 10 Pt 2):1772-1779. doi:10.1107/s0907444902011678
Europe PMC | doi

Frank E, Wolfling J, Aukszi B, Konig V, Schneider TR, Schneider G. (2002)

Stereoselective synthesis of some novel heterocyclic estrone derivatives by intramolecular 1,3-dipolar cycloaddition

Tetrahedron 58:6843-6849. doi:10.1016/S0040-4020(02)00741-X

Konig V, Schneider TR, Frank E, Aukszi B, Schneider G, Wolfling J. (2002)

3-methoxy-1 '-phenyl-4 'beta,5-dihydro-1H-pyrazolo[4 ',3 ': 16,17]estra-1,3,5(10)-triene.

Acta Crystallogr E 58(Pt 8):o810-o811. doi:10.1107/S160053680201125X

Mosch-Zanetti NC, Hewitt M, Schneider TR, Magull J. (2002)

Titanium complexes containing bulky eta(2)-1,2,4-triazolato.

Eur J Inorg Chem 1181-1185. doi:10.1002/1099-0682(200205)2002:53.0.CO;2-Q

Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR. (2002)

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs.

Nat. Struct. Biol. 9(2):107-111. doi:10.1038/nsb746
Europe PMC | doi

Schneider TR. (2002)

A genetic algorithm for the identification of conformationally invariant regions in protein molecules.

Acta Crystallogr. D Biol. Crystallogr. 58(Pt 2):195-208. doi:10.1107/s0907444901019291
Europe PMC | doi


Gellermann E, Klingebiel U, Pape T, Antonia FD, Schneider TR, Schmatz S. (2001)

Silylhydrazines and dimeric N,N '-dilithium-N,N '-bis(silyl)hydrazides - Syntheses, reactions, isomerisations.

Z anorg allg Chem 627(12):2581-2588. doi:10.1002/1521-3749(200112)627:123.0.CO;2-1

Wilmouth RC, Edman K, Neutze R, Wright PA, Clifton IJ, Schneider TR, Schofield CJ, Hajdu J. (2001)

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate

Nat. Struct. Biol. 8(8):689-694. doi:10.1038/90401
Europe PMC | doi


Diedrich F, Klingebiel U, Dall'Antonia F, Lehmann C, Noltemeyer M, Schneider TR. (2000)

Asymmetric tris- and cyclic silylhydroxylamines from trimeric and tetrameric lithium N,N-bis(silyl)hydroxylamides.

Organometallics 19:5376-5383. doi:10.1021/om0006211

Zheng WJ, Mosch-Zanetti NC, Roesky HW, Noltemeyer M, Hewitt M, Schmidt HG, Schneider TR. (2000)

Alumoxane hydride and aluminum chalcogenide hydride compounds with pyrazolato ligands.

Angew Chem Int Ed 39(23):4276-4279. doi:10.1002/1521-3773(20001201)39:233.0.CO;2-8

Zheng W, Mösch-Zanetti NC, Roesky HW, Hewitt M, Cimpoesu F, Schneider TR, Stasch A, Prust J. (2000)

The First Structurally Characterized Aluminum Compounds with Terminal Acetylide Groups.

Angew. Chem. Int. Ed. Engl. 39(17):3099-3101. doi:10.1002/1521-3773(20000901)39:173.0.co;2-w
Europe PMC | doi

Buckley PA, Jackson JB, Schneider T, White SA, Rice DW, Baker PJ. (2000)

Protein-protein recognition, hydride transfer and proton pumping in the transhydrogenase complex.

Structure 8(8):809-815. doi:10.1016/s0969-2126(00)00171-4
Europe PMC | doi

Hewitt M, Schneider TR, Szemeredi Z, Hajnal A, Wolfling J, Schneider G. (2000)

A steroidal phenyldihydro-1,3-oxazine derivative.

Acta Crystallogr C 56:E363-E364. doi:10.1107/S0108270100009628

Schneider TR. (2000)

Objective comparison of protein structures: error-scaled difference distance matrices.

Acta Crystallogr. D Biol. Crystallogr. 56(Pt 6):714-721. doi:10.1107/s0907444900003723
Europe PMC | doi

Schneider TR, Kärcher J, Pohl E, Lubini P, Sheldrick GM. (2000)

Ab initio structure determination of the lantibiotic mersacidin

Acta Crystallogr. D Biol. Crystallogr. 56(Pt 6):705-713. doi:10.1107/s0907444900003711
Europe PMC | doi

Mosch-Zanetti NC, Kratzner R, Lehmann C, Schneider TR, Uson I. (2000)

Titanium(III) compounds with eta(2)-pyrazolato ligands.

Eur J Inorg Chem 13-16. doi:10.1002/(SICI)1099-0682(200001)2000:13.0.CO;2-N


Schneider TR, Hartmann M, Braus GH. (1999)

Crystallization and preliminary X-ray analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tyrosine inhibitable) from Saccharomyces cerevisiae.

Acta Crystallogr. D Biol. Crystallogr. 55(Pt 9):1586-1588. doi:10.1107/s0907444999007830
Europe PMC | doi

Usón I, Pohl E, Schneider TR, Dauter Z, Schmidt A, Fritz HJ, Sheldrick GM. (1999)

1.7 A structure of the stabilized REIv mutant T39K. Application of local NCS restraints

Acta Crystallogr. D Biol. Crystallogr. 55(Pt 6):1158-1167. doi:10.1107/s0907444999003972
Europe PMC | doi

Bravo J, Mate MJ, Schneider T, Switala J, Wilson K, Loewen PC, Fita I. (1999)

Structure of catalase HPII from Escherichia coli at 1.9 angstrom resolution

Proteins 34(2):155-166. doi:10.1002/(sici)1097-0134(19990201)34:23.0.co;2-p
Europe PMC | doi

Schneider TR, Brünger AT, Nilges M. (1999)

Influence of internal dynamics on accuracy of protein NMR structures: derivation of realistic model distance data from a long molecular dynamics trajectory

J. Mol. Biol. 285(2):727-740. doi:10.1006/jmbi.1998.2323
Europe PMC | doi


Walsh MA, Schneider TR, Sieker LC, Dauter Z, Lamzin VS, Wilson KS. (1998)

Refinement of triclinic hen egg-white lysozyme at atomic resolution

Acta Crystallogr. D Biol. Crystallogr. 54(Pt 4):522-546. doi:10.1107/s0907444997013656
Europe PMC | doi

Schneider TR, Gerhardt E, Lee M, Liang PH, Anderson KS, Schlichting I. (1998)

Loop closure and intersubunit communication in tryptophan synthase.

Biochemistry 37(16):5394-5406. doi:10.1021/bi9728957
Europe PMC | doi

Schäfer M, Sheldrick GM, Schneider TR, Vértesy L. (1998)

Structure of balhimycin and its complex with solvent molecules

Acta Crystallogr. D Biol. Crystallogr. 54(Pt 2):175-183. doi:10.1107/s0907444997008895
Europe PMC | doi


Usón I, Bes MT, Sheldrick GM, Schneider TR, Hartsch T, Fritz HJ. (1997)

X-ray crystallography reveals stringent conservation of protein fold after removal of the only disulfide bridge from a stabilized immunoglobulin variable domain.

Fold Des 2(6):357-361. doi:10.1016/s1359-0278(97)00049-7
Europe PMC | doi

Garman EF, Schneider TR. (1997)

Macromolecular cryocrystallography.

J Appl Crystallogr 30:211-237. doi:10.1107/S0021889897002677

Schneider TR. (1997)

Cryocrystallography of biological macromolecules.

Acta Phys Pol A 91:739-744.

Sheldrick GM, Schneider TR. (1997)

SHELXL: high-resolution refinement.

Meth. Enzymol. 277:319-343. doi:10.1016/S0076-6879(97)77018-6
Europe PMC | doi


Schäfer M, Schneider TR, Sheldrick GM. (1996)

Crystal structure of vancomycin.

Structure 4(12):1509-1515. doi:10.1016/s0969-2126(96)00156-6
Europe PMC | doi

Frisch C, Kolmar H, Schmidt A, Kleemann G, Reinhardt A, Pohl E, Usón I, Schneider TR, Fritz HJ. (1996)

Contribution of the intramolecular disulfide bridge to the folding stability of REIv, the variable domain of a human immunoglobulin kappa light chain.

Fold Des 1(6):431-440. doi:10.1016/s1359-0278(96)00059-4
Europe PMC | doi

Hartmann H, Zinser S, Komninos P, Schneider RT, Nienhaus GU, Parak F. (1996)

X-ray structure determination of a metastable state of carbonmonoxy myoglobin after photodissociation.

Proc. Natl. Acad. Sci. U.S.A. 93(14):7013-7016. doi:10.1073/pnas.93.14.7013
Europe PMC | doi

Perrakis A, Schneider TR, AntoniadouVyzas E, Dauter Z, Hamodrakas SJ. (1996)

Refinement of 2-amino-6-(4-methyl-1-piperazinyl)-4-(tricyclo[,7)]dec-1-yl)-1,3,5-triazine at three different temperatures using image-plate data.

J Appl Crystallogr 29:261-264. doi:10.1107/S0021889896000180


Pohl E, Heine A, Sheldrick GM, Dauter Z, Schneider TR, Wilson KS, Kallen J. (1995)

Comparison of different X-ray data-collection systems using the crystal structure of octreotide

Acta Crystallogr. D Biol. Crystallogr. 51(Pt 1):60-68. doi:10.1107/s0907444994006116
Europe PMC | doi


Betzel C, Lorenz S, Fürste JP, Bald R, Zhang M, Schneider TR, Wilson KS, Erdmann VA. (1994)

Crystal structure of domain A of Thermus flavus 5S rRNA and the contribution of water molecules to its structure.

FEBS Lett 351(2):159-164. doi:10.1016/0014-5793(94)00834-5
Europe PMC | doi