EMBL Hamburg c/o DESY, Notkestraße 85, 22607 Hamburg, Germany

Biography

  • PhD 1982, Dr. of Science 1997, Institute of Crystallography, Moscow.
    At EMBL since 1991.
    Group leader since 2003.
    Senior scientist since 2011.

Publications

Total: 444 publication(s)

2011

Shkumatov AV, Chinnathambi S, Mandelkow E, Svergun DI. (2011)

Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering

Proteins 79(7):2122-2131. doi: 10.1002/prot.23033
Europe PMC | doi

Verstraete K, Vandriessche G, Januar M, Elegheert J, Shkumatov AV, Desfosses A, Van Craenenbroeck K, Svergun DI, Gutsche I, Vergauwen B, Savvides SN. (2011)

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

Blood 118(1):60-68. doi: 10.1182/blood-2011-01-329532
Europe PMC | doi

Beich-Frandsen M, Vecerek B, Konarev PV, Sjöblom B, Kloiber K, Hämmerle H, Rajkowitsch L, Miles AJ, Kontaxis G, Wallace BA, Svergun DI, Konrat R, Bläsi U, Djinovic-Carugo K. (2011)

Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq

Nucleic Acids Res. 39(11):4900-4915. doi: 10.1093/nar/gkq1346
Europe PMC | doi

Shang W, Ivanov I, Svergun DI, Borbulevych OY, Aleem AM, Stehling S, Jankun J, Kühn H, Skrzypczak-Jankun E. (2011)

Probing dimerization and structural flexibility of mammalian lipoxygenases by small-angle X-ray scattering

J. Mol. Biol. 409(4):654-668. doi: 10.1016/j.jmb.2011.04.035
Europe PMC | doi

Rochel N, Ciesielski F, Godet J, Moman E, Roessle M, Peluso-Iltis C, Moulin M, Haertlein M, Callow P, Mély Y, Svergun DI, Moras D. (2011)

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings

Nat. Struct. Mol. Biol. 18(5):564-570. doi: 10.1038/nsmb.2054
Europe PMC | doi

Wang E, Ikonen TP, Knaapila M, Svergun D, Logan DT, von Wachenfeldt C. (2011)

Small-angle X-ray scattering study of a Rex family repressor: conformational response to NADH and NAD+ binding in solution

J. Mol. Biol. 408(4):670-683. doi: 10.1016/j.jmb.2011.02.050
Europe PMC | doi

Morgan HP, Schmidt CQ, Guariento M, Blaum BS, Gillespie D, Herbert AP, Kavanagh D, Mertens HD, Svergun DI, Johansson CM, Uhrín D, Barlow PN, Hannan JP. (2011)

Structural basis for engagement by complement factor H of C3b on a self surface

Nat. Struct. Mol. Biol. 18(4):463-470. doi: 10.1038/nsmb.2018
Europe PMC | doi

Tochowicz A, Goettig P, Evans R, Visse R, Shitomi Y, Palmisano R, Ito N, Richter K, Maskos K, Franke D, Svergun D, Nagase H, Bode W, Itoh Y. (2011)

The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions

J. Biol. Chem. 286(9):7587-7600. doi: 10.1074/jbc.m110.178434
Europe PMC | doi

Giehm L, Svergun DI, Otzen DE, Vestergaard B. (2011)

Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

Proc. Natl. Acad. Sci. U.S.A. 108(8):3246-3251. doi: 10.1073/pnas.1013225108
Europe PMC | doi

Clark EA, Crennell S, Upadhyay A, Zozulya AV, Mackay JD, Svergun DI, Bagby S, van den Elsen JM. (2011)

A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d

Mol. Immunol. 48(4):452-462. doi: 10.1016/j.molimm.2010.09.017
Europe PMC | doi

Ghasparian A, Riedel T, Koomullil J, Moehle K, Gorba C, Svergun DI, Perriman AW, Mann S, Tamborrini M, Pluschke G, Robinson JA. (2011)

Engineered synthetic virus-like particles and their use in vaccine delivery

Chembiochem 12(1):100-109. doi: 10.1002/cbic.201000536
Europe PMC | doi

King-Scott J, Konarev PV, Panjikar S, Jordanova R, Svergun DI, Tucker PA. (2011)

Structural characterization of the multidomain regulatory protein Rv1364c from Mycobacterium tuberculosis

Structure 19(1):56-69. doi: 10.1016/j.str.2010.11.010
Europe PMC | doi

Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J. (2011)

The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution

Eur. J. Cell Biol. 90(6-7):515-520. doi: 10.1016/j.ejcb.2010.09.012
Europe PMC | doi

Manikandan K, Geerlof A, Zozulya AV, Svergun DI, Weiss MS. (2011)

Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis

Proteins 79(1):35-49. doi: 10.1002/prot.22856
Europe PMC | doi


2010

Bronstein LM, Shtykova EV, Malyutin A, Dyke JC, Gunn E, Gao X, Stein B, Konarev PV, Dragnea B, Svergun DI. (2010)

Hydrophilization of Magnetic Nanoparticles with Modified Alternating Copolymers. Part 1: The Influence of the Grafting

J Phys Chem C Nanomater Interfaces 114(50):21900-21907. doi: 10.1021/jp107283w
Europe PMC | doi

Kuettner EB, Kettner K, Keim A, Svergun DI, Volke D, Singer D, Hoffmann R, Müller EC, Otto A, Kriegel TM, Sträter N. (2010)

Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization

J. Biol. Chem. 285(52):41019-41033. doi: 10.1074/jbc.m110.185850
Europe PMC | doi

Shtykova EV, Malyutin A, Dyke J, Stein B, Konarev PV, Dragnea B, Svergun DI, Bronstein LM. (2010)

Hydrophilization of Magnetic Nanoparticles with Modified Alternating Copolymers. Part 2: Behavior in solution

J Phys Chem C Nanomater Interfaces 114(50):21908-21913. doi: 10.1021/jp1072846
Europe PMC | doi

Falces J, Arregi I, Konarev PV, Urbaneja MA, Svergun DI, Taneva SG, Bañuelos S. (2010)

Recognition of nucleoplasmin by its nuclear transport receptor importin α/β: insights into a complete import complex

Biochemistry 49(45):9756-9769. doi: 10.1021/bi101179g
Europe PMC | doi

Mosbaek CR, Nolan D, Persson E, Svergun DI, Bukrinsky JT, Vestergaard B. (2010)

Extensive small-angle X-ray scattering studies of blood coagulation factor VIIa reveal interdomain flexibility

Biochemistry 49(45):9739-9745. doi: 10.1021/bi1011207
Europe PMC | doi

Jurk M, Dorn M, Kikhney A, Svergun D, Gärtner W, Schmieder P. (2010)

The switch that does not flip: the blue-light receptor YtvA from Bacillus subtilis adopts an elongated dimer conformation independent of the activation state as revealed by a combined AUC and SAXS study

J. Mol. Biol. 403(1):78-87. doi: 10.1016/j.jmb.2010.08.036
Europe PMC | doi

Mertens HD, Svergun DI. (2010)

Structural characterization of proteins and complexes using small-angle X-ray solution scattering

J. Struct. Biol. 172(1):128-141. doi: 10.1016/j.jsb.2010.06.012
Europe PMC | doi

Pons C, D'Abramo M, Svergun DI, Orozco M, Bernadó P, Fernández-Recio J. (2010)

Structural characterization of protein-protein complexes by integrating computational docking with small-angle scattering data

J. Mol. Biol. 403(2):217-230. doi: 10.1016/j.jmb.2010.08.029
Europe PMC | doi

Bertini I, Giachetti A, Luchinat C, Parigi G, Petoukhov MV, Pierattelli R, Ravera E, Svergun DI. (2010)

Conformational space of flexible biological macromolecules from average data

J. Am. Chem. Soc. 132(38):13553-13558. doi: 10.1021/ja1063923
Europe PMC | doi

Bucher RM, Svergun DI, Muhle-Goll C, Mayans O. (2010)

The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin

J. Mol. Biol. 401(5):843-853. doi: 10.1016/j.jmb.2010.06.011
Europe PMC | doi

Svergun DI. (2010)

Small-angle X-ray and neutron scattering as a tool for structural systems biology

Biol. Chem. 391(7):737-743. doi: 10.1515/bc.2010.093
Europe PMC | doi

Bernadó P, Modig K, Grela P, Svergun DI, Tchorzewski M, Pons M, Akke M. (2010)

Structure and Dynamics of Ribosomal Protein L12: An Ensemble Model Based on SAXS and NMR Relaxation

Biophys. J. 98(10):2374-2382. doi: 10.1016/j.bpj.2010.02.012
Europe PMC | doi

Albesa-Jové D, Bertrand T, Carpenter EP, Swain GV, Lim J, Zhang J, Haire LF, Vasisht N, Braun V, Lange A, von Eichel-Streiber C, Svergun DI, Fairweather NF, Brown KA. (2010)

Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS

J. Mol. Biol. 396(5):1260-1270. doi: 10.1016/j.jmb.2010.01.012
Europe PMC | doi

Giehm L, Vestergaard B, Oliveira C, Pedersen JS, Svergun DI, Pitts K, Krishnamurthy G, Staal R, Reinhart P, Otzen DE. (2010)

Low Resolution Structure of a Membrane-Permeabilizing Oligomer of alpha-Synuclein: the Basis for a High-Throughput Screening of Compounds against alpha-Synuclein Aggregation

BIOPHYS J 98(3):423A.

Prischi F, Konarev PV, Iannuzzi C, Pastore C, Adinolfi S, Martin SR, Svergun DI, Pastore A. (2010)

Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly

Nat Commun 1:95. doi: 10.1038/ncomms1097
Europe PMC | doi

Schmidt CQ, Herbert AP, Mertens HD, Guariento M, Soares DC, Uhrin D, Rowe AJ, Svergun DI, Barlow PN. (2010)

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module

J. Mol. Biol. 395(1):105-122. doi: 10.1016/j.jmb.2009.10.010
Europe PMC | doi


2009

Crowley PB, Matias PM, Khan AR, Roessle M, Svergun DI. (2009)

Metal-mediated self-assembly of a beta-sandwich protein

Chemistry 15(46):12672-12680. doi: 10.1002/chem.200901410
Europe PMC | doi

De Marco V, Gillespie PJ, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov MV, Iliou MS, Lygerou Z, Medema RH, Blow JJ, Svergun DI, Taraviras S, Perrakis A. (2009)

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

Proc. Natl. Acad. Sci. U.S.A. 106(47):19807-19812. doi: 10.1073/pnas.0905281106
Europe PMC | doi

Cierpicki T, Bielnicki J, Zheng M, Gruszczyk J, Kasterka M, Petoukhov M, Zhang A, Fernandez EJ, Svergun DI, Derewenda U, Bushweller JH, Derewenda ZS. (2009)

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA

Protein Sci. 18(10):2067-2079. doi: 10.1002/pro.219
Europe PMC | doi

Taneva SG, Bañuelos S, Falces J, Arregi I, Muga A, Konarev PV, Svergun DI, Velázquez-Campoy A, Urbaneja MA. (2009)

A mechanism for histone chaperoning activity of nucleoplasmin: thermodynamic and structural models

J. Mol. Biol. 393(2):448-463. doi: 10.1016/j.jmb.2009.08.005
Europe PMC | doi

Yadavalli SS, Klipcan L, Zozulya A, Banerjee R, Svergun D, Safro M, Ibba M. (2009)

Large-scale movement of functional domains facilitates aminoacylation by human mitochondrial phenylalanyl-tRNA synthetase

FEBS Lett. 583(19):3204-3208. doi: 10.1016/j.febslet.2009.09.008
Europe PMC | doi

Zeev-Ben-Mordehai T, Mylonas E, Paz A, Peleg Y, Toker L, Silman I, Svergun DI, Sussman JL. (2009)

The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties

Biophys. J. 97(8):2316-2326. doi: 10.1016/j.bpj.2009.07.045
Europe PMC | doi

Gut H, Dominici P, Pilati S, Astegno A, Petoukhov MV, Svergun DI, Grütter MG, Capitani G. (2009)

A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase

J. Mol. Biol. 392(2):334-351. doi: 10.1016/j.jmb.2009.06.080
Europe PMC | doi

Heikkinen OK, Ruskamo S, Konarev PV, Svergun DI, Iivanainen T, Heikkinen SM, Permi P, Koskela H, Kilpeläinen I, Ylänne J. (2009)

Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin

J. Biol. Chem. 284(37):25450-25458. doi: 10.1074/jbc.m109.019661
Europe PMC | doi

Shiozawa K, Konarev PV, Neufeld C, Wilmanns M, Svergun DI. (2009)

Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering

J. Biol. Chem. 284(37):25334-25342. doi: 10.1074/jbc.m109.002311
Europe PMC | doi

Weyand S, Kefala G, Svergun DI, Weiss MS. (2009)

The three-dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation

J. Struct. Funct. Genomics 10(3):209-217. doi: 10.1007/s10969-009-9065-z
Europe PMC | doi

Janssen BJ, Gomes L, Koning RI, Svergun DI, Koster AJ, Fritzinger DC, Vogel CW, Gros P. (2009)

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex

EMBO J. 28(16):2469-2478. doi: 10.1038/emboj.2009.184
Europe PMC | doi

Manolaridis I, Mumtsidu E, Konarev P, Makhov AM, Fullerton SW, Sinz A, Kalkhof S, McGeehan JE, Cary PD, Griffith JD, Svergun D, Kneale GG, Tucker PA. (2009)

Structural and biophysical characterization of the proteins interacting with the herpes simplex virus 1 origin of replication

J. Biol. Chem. 284(24):16343-16353. doi: 10.1074/jbc.m806134200
Europe PMC | doi

Paoletti F, Covaceuszach S, Konarev PV, Gonfloni S, Malerba F, Schwarz E, Svergun DI, Cattaneo A, Lamba D. (2009)

Intrinsic structural disorder of mouse proNGF

Proteins 75(4):990-1009. doi: 10.1002/prot.22311
Europe PMC | doi

Pires R, Hartlieb B, Signor L, Schoehn G, Lata S, Roessle M, Moriscot C, Popov S, Hinz A, Jamin M, Boyer V, Sadoul R, Forest E, Svergun DI, Göttlinger HG, Weissenhorn W. (2009)

A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments

Structure 17(6):843-856. doi: 10.1016/j.str.2009.04.007
Europe PMC | doi

Van Le B, Franke D, Svergun DI, Han T, Hwang HY, Kim KK. (2009)

Structural and functional characterization of soluble endoglin receptor

Biochem. Biophys. Res. Commun. 383(4):386-391. doi: 10.1016/j.bbrc.2009.02.162
Europe PMC | doi

Werner A, Konarev PV, Svergun DI, Hahn U. (2009)

Characterization of a fluorophore binding RNA aptamer by fluorescence correlation spectroscopy and small angle X-ray scattering

Anal. Biochem. 389(1):52-62. doi: 10.1016/j.ab.2009.03.018
Europe PMC | doi

Zanchi D, Konarev PV, Tribet C, Baron A, Svergun DI, Guyot S. (2009)

Rigidity, conformation, and solvation of native and oxidized tannin macromolecules in water-ethanol solution

J Chem Phys 130(24):245103. doi: 10.1063/1.3156020
Europe PMC | doi

Bertini I, Fragai M, Luchinat C, Melikian M, Mylonas E, Sarti N, Svergun DI. (2009)

Interdomain flexibility in full-length matrix metalloproteinase-1 (MMP-1)

J. Biol. Chem. 284(19):12821-12828. doi: 10.1074/jbc.m809627200
Europe PMC | doi

Cheng Z, Saito K, Pisarev AV, Wada M, Pisareva VP, Pestova TV, Gajda M, Round A, Kong C, Lim M, Nakamura Y, Svergun DI, Ito K, Song H. (2009)

Structural insights into eRF3 and stop codon recognition by eRF1

Genes Dev. 23(9):1106-1118. doi: 10.1101/gad.1770109
Europe PMC | doi

Bernadó P, Pérez Y, Blobel J, Fernández-Recio J, Svergun DI, Pons M. (2009)

Structural characterization of unphosphorylated STAT5a oligomerization equilibrium in solution by small-angle X-ray scattering

Protein Sci. 18(4):716-726. doi: 10.1002/pro.83
Europe PMC | doi

Blobel J, Bernadó P, Svergun DI, Tauler R, Pons M. (2009)

Low-resolution structures of transient protein-protein complexes using small-angle X-ray scattering

J. Am. Chem. Soc. 131(12):4378-4386. doi: 10.1021/ja808490b
Europe PMC | doi

Maveyraud L, Niwa H, Guillet V, Svergun DI, Konarev PV, Palmer RA, Peumans WJ, Rougé P, Van Damme EJ, Reynolds CD, Mourey L. (2009)

Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra

Proteins 75(1):89-103. doi: 10.1002/prot.22222
Europe PMC | doi

Sjekloća L, Konarev PV, Eccleston J, Taylor IA, Svergun DI, Pastore A. (2009)

A study of the ultrastructure of fragile-X-related proteins

Biochem. J. 419(2):347-357. doi: 10.1042/bj20082197
Europe PMC | doi

Fagan RP, Albesa-Jové D, Qazi O, Svergun DI, Brown KA, Fairweather NF. (2009)

Structural insights into the molecular organization of the S-layer from Clostridium difficile

Mol. Microbiol. 71(5):1308-1322. doi: 10.1111/j.1365-2958.2009.06603.x
Europe PMC | doi

Paravisi S, Fumagalli G, Riva M, Morandi P, Morosi R, Konarev PV, Petoukhov MV, Bernier S, Chênevert R, Svergun DI, Curti B, Vanoni MA. (2009)

Kinetic and mechanistic characterization of Mycobacterium tuberculosis glutamyl-tRNA synthetase and determination of its oligomeric structure in solution

FEBS J. 276(5):1398-1417. doi: 10.1111/j.1742-4658.2009.06880.x
Europe PMC | doi

Takács E, Barabás O, Petoukhov MV, Svergun DI, Vértessy BG. (2009)

Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers

FEBS Lett. 583(5):865-871. doi: 10.1016/j.febslet.2009.02.011
Europe PMC | doi

Franke D, Svergun DI. (2009)

DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering

J Appl Crystallogr 42:342-346.
Europe PMC


2008

Zanchi D, Poulain C, Konarev P, Tribet C, Svergun DI. (2008)

Colloidal stability of tannins: astringency, wine tasting and beyond

J PHYS-CONDENS MAT 20(49) doi: 10.1088/0953-8984/20/49/494224
doi

Diepholz M, Venzke D, Prinz S, Batisse C, Flörchinger B, Rössle M, Svergun DI, Böttcher B, Féthière J. (2008)

A different conformation for EGC stator subcomplex in solution and in the assembled yeast V-ATPase: possible implications for regulatory disassembly

Structure 16(12):1789-1798. doi: 10.1016/j.str.2008.09.010
Europe PMC | doi

Bronstein LM, Kostylev M, Shtykova E, Vlahu T, Huang X, Stein BD, Bykov A, Remmes NB, Baxter DV, Svergun DI. (2008)

Mixed Co/Fe oxide nanoparticles in block copolymer micelles

Langmuir 24(21):12618-12626. doi: 10.1021/la8021276
Europe PMC | doi

Høiberg-Nielsen R, Tofteng Shelton AP, Sørensen KK, Roessle M, Svergun DI, Thulstrup PW, Jensen KJ, Arleth L. (2008)

3- Instead of 4-helix formation in a de novo designed protein in solution revealed by small-angle X-ray scattering

Chembiochem 9(16):2663-2672. doi: 10.1002/cbic.200800263
Europe PMC | doi

Round AR, Franke D, Moritz S, Huchler R, Fritsche M, Malthan D, Klaering R, Svergun DI, Roessle M. (2008)

Automated sample-changing robot for solution scattering experiments at the EMBL Hamburg SAXS station X33

J Appl Crystallogr 41:913-917. doi: 10.1107/S0021889808021018
doi

Covaceuszach S, Cassetta A, Konarev PV, Gonfloni S, Rudolph R, Svergun DI, Lamba D, Cattaneo A. (2008)

Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody

J. Mol. Biol. 381(4):881-896. doi: 10.1016/j.jmb.2008.06.008
Europe PMC | doi

Mylonas E, Hascher A, Bernadó P, Blackledge M, Mandelkow E, Svergun DI. (2008)

Domain conformation of tau protein studied by solution small-angle X-ray scattering

Biochemistry 47(39):10345-10353. doi: 10.1021/bi800900d
Europe PMC | doi

Petoukhov MV, Vicente JB, Crowley PB, Carrondo MA, Teixeira M, Svergun DI. (2008)

Quaternary structure of flavorubredoxin as revealed by synchrotron radiation small-angle X-ray scattering

Structure 16(9):1428-1436. doi: 10.1016/j.str.2008.06.009
Europe PMC | doi

Gabel F, Simon B, Nilges M, Petoukhov M, Svergun D, Sattler M. (2008)

A structure refinement protocol combining NMR residual dipolar couplings and small angle scattering restraints

J. Biomol. NMR 41(4):199-208. doi: 10.1007/s10858-008-9258-y
Europe PMC | doi

Grela P, Bernadó P, Svergun D, Kwiatowski J, Abramczyk D, Grankowski N, Tchórzewski M. (2008)

Structural relationships among the ribosomal stalk proteins from the three domains of life

J. Mol. Evol. 67(2):154-167. doi: 10.1007/s00239-008-9132-2
Europe PMC | doi

Pavkov T, Egelseer EM, Tesarz M, Svergun DI, Sleytr UB, Keller W. (2008)

The structure and binding behavior of the bacterial cell surface layer protein SbsC

Structure 16(8):1226-1237. doi: 10.1016/j.str.2008.05.012
Europe PMC | doi

Paz A, Zeev-Ben-Mordehai T, Lundqvist M, Sherman E, Mylonas E, Weiner L, Haran G, Svergun DI, Mulder FA, Sussman JL, Silman I. (2008)

Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3

Biophys. J. 95(4):1928-1944. doi: 10.1529/biophysj.107.126995
Europe PMC | doi

Esposito C, Pethoukov MV, Svergun DI, Ruggiero A, Pedone C, Pedone E, Berisio R. (2008)

Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis

J. Bacteriol. 190(13):4749-4753. doi: 10.1128/jb.01988-07
Europe PMC | doi

Laux V, Callow P, Svergun DI, Timmins PA, Forsyth VT, Haertlein M. (2008)

Selective deuteration of tryptophan and methionine residues in maltose binding protein: a model system for neutron scattering

Eur. Biophys. J. 37(6):815-822. doi: 10.1007/s00249-008-0280-5
Europe PMC | doi

Szabó J, Varga A, Flachner B, Konarev PV, Svergun DI, Závodszky P, Vas M. (2008)

Communication between the nucleotide site and the main molecular hinge of 3-phosphoglycerate kinase

Biochemistry 47(26):6735-6744. doi: 10.1021/bi800411w
Europe PMC | doi

Bertini I, Calderone V, Fragai M, Jaiswal R, Luchinat C, Melikian M, Mylonas E, Svergun DI. (2008)

Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12

J. Am. Chem. Soc. 130(22):7011-7021. doi: 10.1021/ja710491y
Europe PMC | doi

Burman JD, Leung E, Atkins KL, O'Seaghdha MN, Lango L, Bernadó P, Bagby S, Svergun DI, Foster TJ, Isenman DE, van den Elsen JM. (2008)

Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus

J. Biol. Chem. 283(25):17579-17593. doi: 10.1074/jbc.m800265200
Europe PMC | doi

Riek U, Scholz R, Konarev P, Rufer A, Suter M, Nazabal A, Ringler P, Chami M, Müller SA, Neumann D, Forstner M, Hennig M, Zenobi R, Engel A, Svergun D, Schlattner U, Wallimann T. (2008)

Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding

J. Biol. Chem. 283(26):18331-18343. doi: 10.1074/jbc.m708379200
Europe PMC | doi

Weghofer M, Dall'Antonia Y, Grote M, Stöcklinger A, Kneidinger M, Balic N, Krauth MT, Fernández-Caldas E, Thomas WR, van Hage M, Vieths S, Spitzauer S, Horak F, Svergun DI, Konarev PV, Valent P, Thalhamer J, Keller W, Valenta R, Vrtala S. (2008)

Characterization of Der p 21, a new important allergen derived from the gut of house dust mites

Allergy 63(6):758-767. doi: 10.1111/j.1398-9995.2008.01647.x
Europe PMC | doi

Jørgensen AD, Nøhr J, Kastrup JS, Gajhede M, Sigurskjold BW, Sauer J, Svergun DI, Svensson B, Vestergaard B. (2008)

Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution

J. Biol. Chem. 283(21):14772-14780. doi: 10.1074/jbc.m801709200
Europe PMC | doi

Lata S, Roessle M, Solomons J, Jamin M, Gottlinger HG, Svergun DI, Weissenhorn W. (2008)

Structural basis for autoinhibition of ESCRT-III CHMP3

J. Mol. Biol. 378(4):818-827. doi: 10.1016/j.jmb.2008.03.030
Europe PMC | doi

Xu X, Reinle W, Hannemann F, Konarev PV, Svergun DI, Bernhardt R, Ubbink M. (2008)

Dynamics in a pure encounter complex of two proteins studied by solution scattering and paramagnetic NMR spectroscopy

J. Am. Chem. Soc. 130(20):6395-6403. doi: 10.1021/ja7101357
Europe PMC | doi

Shukla A, Mylonas E, Di Cola E, Finet S, Timmins P, Narayanan T, Svergun DI. (2008)

Absence of equilibrium cluster phase in concentrated lysozyme solutions

Proc. Natl. Acad. Sci. U.S.A. 105(13):5075-5080. doi: 10.1073/pnas.0711928105
Europe PMC | doi

Szabó J, Varga A, Flachner B, Konarev PV, Svergun DI, Závodszky P, Vas M. (2008)

Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase

FEBS Lett. 582(9):1335-1340. doi: 10.1016/j.febslet.2008.03.016
Europe PMC | doi

Cottevieille M, Larquet E, Jonic S, Petoukhov MV, Caprini G, Paravisi S, Svergun DI, Vanoni MA, Boisset N. (2008)

The subnanometer resolution structure of the glutamate synthase 1.2-MDa hexamer by cryoelectron microscopy and its oligomerization behavior in solution: functional implications

J. Biol. Chem. 283(13):8237-8249. doi: 10.1074/jbc.m708529200
Europe PMC | doi

Hillig RC, Urlinger S, Fanghänel J, Brocks B, Haenel C, Stark Y, Sülzle D, Svergun DI, Baesler S, Malawski G, Moosmayer D, Menrad A, Schirner M, Licha K. (2008)

Fab MOR03268 triggers absorption shift of a diagnostic dye via packaging in a solvent-shielded Fab dimer interface

J. Mol. Biol. 377(1):206-219. doi: 10.1016/j.jmb.2007.12.071
Europe PMC | doi

Niemann HH, Petoukhov MV, Härtlein M, Moulin M, Gherardi E, Timmins P, Heinz DW, Svergun DI. (2008)

X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlB

J. Mol. Biol. 377(2):489-500. doi: 10.1016/j.jmb.2008.01.027
Europe PMC | doi

Youles M, Holmes O, Petoukhov MV, Nessen MA, Stivala S, Svergun DI, Gherardi E. (2008)

Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist

J. Mol. Biol. 377(3):616-622. doi: 10.1016/j.jmb.2008.01.034
Europe PMC | doi

Aleem AM, Jankun J, Dignam JD, Walther M, Kühn H, Svergun DI, Skrzypczak-Jankun E. (2008)

Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure

J. Mol. Biol. 376(1):193-209. doi: 10.1016/j.jmb.2007.11.086
Europe PMC | doi

Bernadó P, Pérez Y, Svergun DI, Pons M. (2008)

Structural characterization of the active and inactive states of Src kinase in solution by small-angle X-ray scattering

J. Mol. Biol. 376(2):492-505. doi: 10.1016/j.jmb.2007.11.066
Europe PMC | doi

Mumtsidu E, Makhov AM, Konarev PV, Svergun DI, Griffith JD, Tucker PA. (2008)

Structural features of the single-stranded DNA-binding protein of Epstein-Barr virus

J. Struct. Biol. 161(2):172-187. doi: 10.1016/j.jsb.2007.10.014
Europe PMC | doi

She M, Decker CJ, Svergun DI, Round A, Chen N, Muhlrad D, Parker R, Song H. (2008)

Structural basis of dcp2 recognition and activation by dcp1

Mol. Cell 29(3):337-349. doi: 10.1016/j.molcel.2008.01.002
Europe PMC | doi

Tikhonova TV, Slutskaya ES, Filimonenkov AA, Boyko KM, Kleimenov SY, Konarev PV, Polyakov KM, Svergun DI, Trofimov AA, Khomenkov VG, Zvyagilskaya RA, Popov VO. (2008)

Isolation and oligomeric composition of cytochrome c nitrite reductase from the haloalkaliphilic bacterium Thioalkalivibrio nitratireducens

Biochemistry Mosc. 73(2):164-170. doi: 10.1134/s0006297908020077
Europe PMC | doi

Varga A, Szabó J, Flachner B, Roy B, Konarev P, Svergun D, Závodszky P, Périgaud C, Barman T, Lionne C, Vas M. (2008)

Interaction of human 3-phosphoglycerate kinase with L-ADP, the mirror image of D-ADP

Biochem. Biophys. Res. Commun. 366(4):994-1000. doi: 10.1016/j.bbrc.2007.12.061
Europe PMC | doi

Lamber EP, Wilmanns M, Svergun DI. (2008)

Low resolution structural models of the basic helix-loop-helix leucine zipper domain of upstream stimulatory factor 1 and its complexes with DNA from small angle X-ray scattering data

Biophys. J. 94(1):193-197. doi: 10.1529/biophysj.107.112243
Europe PMC | doi

Majava V, Petoukhov MV, Hayashi N, Pirilä P, Svergun DI, Kursula P. (2008)

Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure

BMC Struct. Biol. 8:10. doi: 10.1186/1472-6807-8-10
Europe PMC | doi

Pinotsis N, Lange S, Perriard JC, Svergun DI, Wilmanns M. (2008)

Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin

EMBO J. 27(1):253-264. doi: 10.1038/sj.emboj.7601944
Europe PMC | doi

Shtykova EV, Huang X, Gao X, Dyke JC, Schmucker AL, Dragnea B, Remmes N, Baxter DV, Stein B, Konarev PV, Svergun DI, Bronstein LM. (2008)

Hydrophilic Monodisperse Magnetic Nanoparticles Protected by an Amphiphilic Alternating Copolymer

J Phys Chem C Nanomater Interfaces 112(43):16809-16817. doi: 10.1021/jp8053636
Europe PMC | doi

Svergun DI, Ekström F, Vandegriff KD, Malavalli A, Baker DA, Nilsson C, Winslow RM. (2008)

Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: implications for a new oxygen therapeutic

Biophys. J. 94(1):173-181. doi: 10.1529/biophysj.107.114314
Europe PMC | doi

von Castelmur E, Marino M, Svergun DI, Kreplak L, Ucurum-Fotiadis Z, Konarev PV, Urzhumtsev A, Labeit D, Labeit S, Mayans O. (2008)

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain

Proc. Natl. Acad. Sci. U.S.A. 105(4):1186-1191. doi: 10.1073/pnas.0707163105
Europe PMC | doi


2007

King-Scott J, Nowak E, Mylonas E, Panjikar S, Roessle M, Svergun DI, Tucker PA. (2007)

The structure of a full-length response regulator from Mycobacterium tuberculosis in a stabilized three-dimensional domain-swapped, activated state

J. Biol. Chem. 282(52):37717-37729. doi: 10.1074/jbc.m705081200
Europe PMC | doi

Petoukhov MV, Svergun DI. (2007)

Analysis of X-ray and neutron scattering from biomacromolecular solutions

Curr. Opin. Struct. Biol. 17(5):562-571. doi: 10.1016/j.sbi.2007.06.009
Europe PMC | doi

Mastrangelo E, Milani M, Bollati M, Selisko B, Peyrane F, Pandini V, Sorrentino G, Canard B, Konarev PV, Svergun DI, de Lamballerie X, Coutard B, Khromykh AA, Bolognesi M. (2007)

Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein

J. Mol. Biol. 372(2):444-455. doi: 10.1016/j.jmb.2007.06.055
Europe PMC | doi