EMBL Hamburg c/o DESY, Notkestraße 85, 22607 Hamburg, Germany

Biography

  • PhD 1982, Dr. of Science 1997, Institute of Crystallography, Moscow.
    At EMBL since 1991.
    Group leader since 2003.
    Senior scientist since 2011.

Publications

Total: 455 publication(s)

2001

Koch MHJ, Svergun DI, Gabriel A, Goderis B, Unruh T. (2001)

Recent developments in synchrotron radiation X-ray scattering on (bio)-polymers

ABSTR PAP AM CHEM S 222:U355.

Svergun DI, Shtykova EV, Kozin MB, Volkov VV, Konarev PV, Dembo AT, Shtykova EV, Bronshtein LM, Chernyshov DM, Platonova OA, Yakunin AN, Valetsky PM, Khokhlov AR. (2001)

Small-angle X-ray scattering study of the structure of self-organized polymer matrices and formation of imbedded metal nanoparticles

CRYSTALLOGR REP+ 46(4):586-595. doi: 10.1134/1.1387124
doi

Svergun DI, Zaccai G, Malfois M, Wade RH, Koch MH, Kozielski F. (2001)

Conformation of the Drosophila motor protein non-claret disjunctional in solution from X-ray and neutron scattering

J. Biol. Chem. 276(27):24826-24832. doi: 10.1074/jbc.m103618200
Europe PMC | doi

Svergun DI, Petoukhov MV, Koch MH. (2001)

Determination of domain structure of proteins from X-ray solution scattering

Biophys. J. 80(6):2946-2953. doi: 10.1016/s0006-3495(01)76260-1
Europe PMC | doi

Feil IK, Malfois M, Hendle J, van Der Zandt H, Svergun DI. (2001)

A novel quaternary structure of the dimeric alpha-crystallin domain with chaperone-like activity

J. Biol. Chem. 276(15):12024-12029. doi: 10.1074/jbc.m010856200
Europe PMC | doi

Grüber G, Svergun DI, Coskun U, Lemker T, Koch MH, Schägger H, Müller V. (2001)

Structural Insights into the A1 ATPase from the archaeon, Methanosarcina mazei Go1

Biochemistry 40(7):1890-1896. doi: 10.1021/bi002195t
Europe PMC | doi

Bronstein LM, Svergun DI, Khokhlov AR. (2001)

Metal nanoparticle formation in polyelectrolyte gels with regular microstructures

CRC Press.
Europe PMC

Konarev PV, Petoukhov MV, Svergun DI. (2001)

MASSHA - a graphics system for rigid-body modelling of macromolecular complexes against solution scattering data

J Appl Crystallogr 34:527-532. doi: 10.1107/S0021889801006100
Europe PMC | doi

Kozielski F, Svergun D, Zaccai G, Wade RH, Koch MH. (2001)

The overall conformation of conventional kinesins studied by small angle X-ray and neutron scattering

J. Biol. Chem. 276(2):1267-1275. doi: 10.1074/jbc.m007169200
Europe PMC | doi

Kozin MB, Svergun DI. (2001)

Automated matching of high- and low-resolution structural models

J Appl Crystallogr 34(`):33-41. doi: 10.1107/S0021889800014126
Europe PMC | doi


2000

Funari SS, Rapp G, Perbandt M, Dierks K, Vallazza M, Betzel C, Erdmann VA, Svergun DI. (2000)

Structure of free Thermus flavus 5 S rRNA at 1.3 nm resolution from synchrotron X-ray solution scattering

J. Biol. Chem. 275(40):31283-31288. doi: 10.1074/jbc.m004974200
Europe PMC | doi

Grüber G, Svergun DI, Godovac-Zimmermann J, Harvey WR, Wieczorek H, Koch MH. (2000)

Evidence for major structural changes in the Manduca sexta midgut V1 ATPase due to redox modulation. A small angle X-ray scattering study

J. Biol. Chem. 275(39):30082-30087. doi: 10.1074/jbc.m002976200
Europe PMC | doi

Svergun DI, Bećirević A, Schrempf H, Koch MH, Grüber G. (2000)

Solution structure and conformational changes of the Streptomyces chitin-binding protein (CHB1)

Biochemistry 39(35):10677-10683. doi: 10.1021/bi000865p
Europe PMC | doi

Svergun DI, Nierhaus KH. (2000)

A map of protein-rRNA distribution in the 70 S Escherichia coli ribosome

J. Biol. Chem. 275(19):14432-14439. doi: 10.1074/jbc.275.19.14432
Europe PMC | doi

Gabashvili IS, Agrawal RK, Spahn CM, Grassucci RA, Svergun DI, Frank J, Penczek P. (2000)

Solution structure of the E. coli 70S ribosome at 11.5 A resolution

Cell 100(5):537-549. doi: 10.1016/s0092-8674(00)80690-x
Europe PMC | doi

Svergun DI, Malfois M, Koch MH, Wigneshweraraj SR, Buck M. (2000)

Low resolution structure of the sigma54 transcription factor revealed by X-ray solution scattering

J. Biol. Chem. 275(6):4210-4214. doi: 10.1074/jbc.275.6.4210
Europe PMC | doi

Dainese E, Svergun D, Beltramini M, Di Muro P, Salvato B. (2000)

Low-resolution structure of the proteolytic fragments of the Rapana venosa hemocyanin in solution

Arch. Biochem. Biophys. 373(1):154-162. doi: 10.1006/abbi.1999.1514
Europe PMC | doi

Fan LX, Svergun DI, Volkov VV, Aksenov VL, Algalarov CC, Selivanova OM, Shcherbakova IV, Koch M, Gilles R, Wiedenmann A, May R, Serdyuk IN. (2000)

Structural studies of the 30S subunit of ribosomes Thermus thermophilus by small-angle neutron and X-ray scattering

J Appl Crystallogr 33(1):515-518. doi: 10.1107/S0021889800098009
Europe PMC | doi

Kozin MB, Svergun DI. (2000)

A software system for rigid-body modelling of solution scattering data

J Appl Crystallogr 33(3 Part 1):775-777. doi: 10.1107/S0021889800001382
Europe PMC | doi

Malfois M, Svergun DI. (2000)

sasCIF: an extension of core Crystallographic Information File for SAS

J Appl Crystallogr 33(1):812-816. doi: 10.1107/S0021889800001357
Europe PMC | doi

Svergun DI. (2000)

Advanced solution scattering data analysis methods and their applications

J Appl Crystallogr 33(1):530-534. doi: 10.1107/S0021889800001370
Europe PMC | doi

Svergun DI, Konarev PV, Volkov VV, Koch MHJ, Sager WFC, Smeets J, Blokhuis M. (2000)

A small angle x-ray scattering study of the droplet-cylinder transition in oil-rich sodium bis(2-ethylhexyl) sulfosuccinate microemulsions

J Chem Phys 113(4):1651-1665. doi: 10.1063/1.481954
Europe PMC | doi

Svergun DI, Kozin MB, Konarev PV, Shtykova EV, Volkov VV, Chernyshov DM, Valetsky PM, Bronstein LM. (2000)

Formation of metal nanoparticles in multilayered poly(octadecylsiloxane) as revealed by anomalous small-angle X-ray scattering

Chem Mater 12(12):3552-3560. doi: 10.1021/cm001103j
Europe PMC | doi

Svergun DI, Petoukhov MV, Koch MH, König S. (2000)

Crystal versus solution structures of thiamine diphosphate-dependent enzymes

J. Biol. Chem. 275(1):297-302. doi: 10.1074/jbc.275.1.297
Europe PMC | doi

Svergun DI, Shtykova EV, Kozin MB, Volkov VV, Dembo AT, Shtykova EV, Bronstein LM, Platonova OA, Yakunin AN, Valetsky PM. (2000)

Small-angle X-ray scattering study of platinum-containing hydrogel/surfactant complexes

J Phys Chem B 104(22):5242-5250. doi: 10.1021/jp994425n
Europe PMC | doi


1999

Svergun DI. (1999)

Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing (vol 76, pg 2879, 1999)

BIOPHYS J 77(5):2896.

Serdyuk I, Ulitin A, Kolesnikov I, Vasiliev V, Aksenov V, Zaccai G, Svergun D, Kozin M, Willumeit R. (1999)

Structure of a beheaded 30 S ribosomal subunit from Thermus thermophilus

J. Mol. Biol. 292(3):633-639. doi: 10.1006/jmbi.1999.3109
Europe PMC | doi

Abele R, Svergun D, Keinänen K, Koch MH, Madden DR. (1999)

A molecular envelope of the ligand-binding domain of a glutamate receptor in the presence and absence of agonist

Biochemistry 38(34):10949-10957. doi: 10.1021/bi982928y
Europe PMC | doi

Aleshin AE, Malfois M, Liu X, Kim CS, Fromm HJ, Honzatko RB, Koch MH, Svergun DI. (1999)

Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution

Biochemistry 38(26):8359-8366. doi: 10.1021/bi990523n
Europe PMC | doi

Sayers Z, Brouillon P, Svergun DI, Zielenkiewicz P, Koch MH. (1999)

Biochemical and structural characterization of recombinant copper-metallothionein from Saccharomyces cerevisiae

Eur. J. Biochem. 262(3):858-865. doi: 10.1046/j.1432-1327.1999.00451.x
Europe PMC | doi

Svergun DI. (1999)

Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing

Biophys. J. 76(6):2879-2886. doi: 10.1016/s0006-3495(99)77443-6
Europe PMC | doi

Barone G, Sayers Z, Svergun D, Koch MHJ. (1999)

A synchrotron radiation X-ray scattering study of aqueous solutions of native DNA

J Synchrotron Radiat 6:1031-1034. doi: 10.1107/s0909049599007463
Europe PMC | doi

Fan LX, Serdyuk IN, Gilles R, May R, Svergun DI. (1999)

Structural model of the 30S subunit of a ribosome Thermus Thermophilu by small-angle scattering

KFKI PREP R 1999(2):69-71.


1998

Svergun DI, Konrad S, Huss M, Koch MH, Wieczorek H, Altendorf K, Volkov VV, Grüber G. (1998)

Quaternary structure of V1 and F1 ATPase: significance of structural homologies and diversities

Biochemistry 37(51):17659-17663. doi: 10.1021/bi982367a
Europe PMC | doi

Svergun DI, Aldag I, Sieck T, Altendorf K, Koch MH, Kane DJ, Kozin MB, Grüber G. (1998)

A model of the quaternary structure of the Escherichia coli F1 ATPase from X-ray solution scattering and evidence for structural changes in the delta subunit during ATP hydrolysis

Biophys. J. 75(5):2212-2219. doi: 10.1016/s0006-3495(98)77665-9
Europe PMC | doi

Macheroux P, Schönbrunn E, Svergun DI, Volkov VV, Koch MH, Bornemann S, Thorneley RN. (1998)

Evidence for a major structural change in Escherichia coli chorismate synthase induced by flavin and substrate binding

Biochem. J. 335 ( Pt 2):319-327. doi: 10.1042/bj3350319
Europe PMC | doi

Shilton B, Svergun DI, Volkov VV, Koch MH, Cusack S, Economou A. (1998)

Escherichia coli SecA shape and dimensions

FEBS Lett. 436(2):277-282. doi: 10.1016/s0014-5793(98)01141-7
Europe PMC | doi

Bilgin N, Ehrenberg M, Ebel C, Zaccai G, Sayers Z, Koch MH, Svergun DI, Barberato C, Volkov V, Nissen P, Nyborg J. (1998)

Solution structure of the ternary complex between aminoacyl-tRNA, elongation factor Tu, and guanosine triphosphate

Biochemistry 37(22):8163-8172. doi: 10.1021/bi9802869
Europe PMC | doi

König S, Svergun DI, Volkov VV, Feigin LA, Koch MH. (1998)

Small-angle X-ray solution-scattering studies on ligand-induced subunit interactions of the thiamine diphosphate dependent enzyme pyruvate decarboxylase from different organisms

Biochemistry 37(15):5329-5334. doi: 10.1021/bi972125v
Europe PMC | doi

Schönbrunn E, Svergun DI, Amrhein N, Koch MH. (1998)

Studies on the conformational changes in the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine enolpyruvyltransferase (MurA)

Eur. J. Biochem. 253(2):406-412. doi: 10.1046/j.1432-1327.1998.2530406.x
Europe PMC | doi

Svergun DI, Richard S, Koch MH, Sayers Z, Kuprin S, Zaccai G. (1998)

Protein hydration in solution: experimental observation by x-ray and neutron scattering

Proc. Natl. Acad. Sci. U.S.A. 95(5):2267-2272. doi: 10.1073/pnas.95.5.2267
Europe PMC | doi

Svergun DI, Shtykova EV, Dembo AT, Bronstein LM, Platonova OA, Yakunin AN, Valetsky PM, Khokhlov AR. (1998)

Size distributions of metal nanoparticles in polyelectrolyte gels

J Chem Phys 109(24):11109-11116. doi: 10.1063/1.477749
Europe PMC | doi


1997

Svergun DI. (1997)

A weighted rotation function

ACTA CRYSTALLOGR D 53:789-791. doi: 10.1107/S0907444997006197
Europe PMC | doi

Kozin MB, Volkov VV, Svergun DI. (1997)

ASSA, a program for three-dimensional rendering in solution scattering from biopolymers

J APPL CRYSTALLOGR 30(2):811-815. doi: 10.1107/S0021889897001830
doi

Svergun DI. (1997)

Restoring three-dimensional structure of biopolymers from solution scattering

J APPL CRYSTALLOGR 30(2):792-797. doi: 10.1107/S0021889897001039
doi

Svergun DI, Volkov VV, Kozin MB, Stuhrmann HB, Barberato C, Koch MHJ. (1997)

Shape determination from solution scattering of biopolymers

J APPL CRYSTALLOGR 30(2):798-802. doi: 10.1107/S0021889897001714
doi

Svergun DI, Burkhardt N, Pedersen JS, Koch MHJ, Volkov VV, Kozin MB, Meerwink W, Stuhrmann HB, Diedrich G, Nierhaus KH. (1997)

Solution scattering structural analysis of the 70 S Escherichia coli ribosome by contrast variation .1. Invariants and validation of electron microscopy models

J MOL BIOL 271(4):588-601. doi: 10.1006/jmbi.1997.1190
Europe PMC | doi

Svergun DI, Burkhardt N, Pedersen JS, Koch MHJ, Volkov VV, Kozin MB, Meerwink W, Stuhrmann HB, Diedrich G, Nierhaus KH. (1997)

Solution scattering structural analysis of the 70 S Escherichia coli ribosome by contrast variation .2. A model of the ribosome and its RNA at 3.5 nm resolution

J MOL BIOL 271(4):602-618. doi: 10.1006/jmbi.1997.1191
Europe PMC | doi

Burkhardt N, Diedrich G, Nierhaus KH, Meerwinck W, Stuhrmann HB, Pedersen JS, Koch MHJ, Volkov VV, Kozin MB, Svergun DI. (1997)

Architecture of the E-coli 70S ribosome

PHYSICA B 234:199-201. doi: 10.1016/S0921-4526(96)00910-6
doi

Kozin MB, Volkov VV, Svergun DI. (1997)

A compact algorithm for evaluating linear prolate functions

IEEE T SIGNAL PROCES 45(4):1075-1078. doi: 10.1109/78.564197
doi

Svergun DI, Barberato C, Koch MH, Fetler L, Vachette P. (1997)

Large differences are observed between the crystal and solution quaternary structures of allosteric aspartate transcarbamylase in the R state

Proteins 27(1):110-117. doi: 10.1002/(sici)1097-0134(199701)27:1<110::aid-prot11>3.3.co;2-x
Europe PMC | doi


1996

Kozin MB, Svergun DI. (1996)

Small-angle scattering data processing using linear prolate spheroidal functions

KRISTALLOGRAFIYA+ 41(5):817-825.

Svergun DI, Volkov VV, Kozin MB, Stuhrmann HB. (1996)

New developments in direct shape determination from small-angle scattering .2. Uniqueness

ACTA CRYSTALLOGR A 52:419-426. doi: 10.1107/S0108767396000177
doi

Svergun DI, Koch MHJ, Pedersen JS, Serdyuk IN. (1996)

Structural model of the 50S subunit of E-coli ribosomes from solution scattering

BASIC LIFE SCI 64:149-174.
Europe PMC


1992

Svergun DI. (1992)

Determination of the regularization parameter in indirect-transform methods using perceptual criteria

J Appl Crystallogr 25:495-503.
Europe PMC