Staff at EMBL

Dr. Matthias Wilmanns

Head of Outstation and Senior Scientist
Wilmanns Group

EMBL Hamburg c/o DESY, Notkestraße 85, 22603 Hamburg, Germany

E-mail:	send a mail
Web page:	http://www.embl-hamburg.de/~wilmanns/home.html

Biography

PhD 1990, University of Basel (Switzerland).
Postdoc at the University of California, Los Angeles, 1991-1993.
Postdoc and Staff Scientist at EMBL Heidelberg 1993-1996.
Group Leader and Head of EMBL Hamburg since 1997.
PhD h.c. 2013, University of Oulu (Finland).

Publications

A unique Oct4 interface is crucial for reprogramming to pluripotency. Esch, D., Vahokoski, J., Groves, M.R., Pogenberg, V., Cojocaru, V., Vom Bruch, H., Han, D., Drexler, H.C., Arauzo-Bravo, M.J., Ng, C.K., Jauch, R., Wilmanns, M. & Scholer, H.R. Nat Cell Biol. 2013 Feb 3;15(3):295-301. doi: 10.1038/ncb2680. Epub 2013 Feb 3. PubMed

Catalysis uncoupling in a glutamine amidotransferase bienzyme by unblocking the glutaminase active site. List, F., Vega, M.C., Razeto, A., Hager, M.C., Sterner, R. & Wilmanns, M. Chem Biol. 2012 Dec 21;19(12):1589-99. doi: 10.1016/j.chembiol.2012.10.012. PubMed

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Pogenberg, V., Ogmundsdottir, M.H., Bergsteinsdottir, K., Schepsky, A., Phung, B., Deineko, V., Milewski, M., Steingrimsson, E. & Wilmanns, M. Genes Dev. 2012 Dec 1;26(23):2647-58. doi: 10.1101/gad.198192.112. PubMed

Structural characterization of a D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus. Holton, S.J., Anandhakrishnan, M., Geerlof, A. & Wilmanns, M. J Struct Biol. 2012 Oct 27. pii: S1047-8477(12)00291-2. doi:10.1016/j.jsb.2012.10.009. PubMed

Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase. Burns, K.E., McAllister, F.E., Schwerdtfeger, C., Mintseris, J., Cerda-Maira, F., Noens, E.E., Wilmanns, M., Hubbard, S.R., Melandri, F., Ovaa, H., Gygi, S.P. & Darwin, K.H. J Biol Chem. 2012 Oct 26;287(44):37522-9. doi: 10.1074/jbc.M112.384784. Epub 2012Aug 31. PubMed

The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase. Kuper, J., Tee, K.L., Wilmanns, M., Roccatano, D., Schwaneberg, U. & Wong, T.S. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Sep 1;68(Pt 9):1013-7.doi: 10.1107/S1744309112031570. Epub 2012 Aug 29. PubMed

Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. Heja, D., Harmat, V., Fodor, K., Wilmanns, M., Dobo, J., Kekesi, K.A., Zavodszky, P., Gal, P. & Pal, G. J Biol Chem. 2012 Jun 8;287(24):20290-300. doi: 10.1074/jbc.M112.354332. Epub2012 Apr 16. PubMed

Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1. Fodor, K., Wolf, J., Erdmann, R., Schliebs, W. & Wilmanns, M. PLoS Biol. 2012;10(4):e1001309. doi: 10.1371/journal.pbio.1001309. Epub 2012 Apr17. PubMed

Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. Pinotsis, N., Chatziefthimiou, S.D., Berkemeier, F., Beuron, F., Mavridis, I.M., Konarev, P.V., Svergun, D.I., Morris, E., Rief, M. & Wilmanns, M. PLoS Biol. 2012 Feb;10(2):e1001261. doi: 10.1371/journal.pbio.1001261. Epub 2012Feb 14. PubMed

Two immunoglobulin tandem proteins with a linking beta-strand reveal unexpected differences in cooperativity and folding pathways. Steward, A., Chen, Q., Chapman, R.I., Borgia, M.B., Rogers, J.M., Wojtala, A., Wilmanns, M. & Clarke, J. J Mol Biol. 2012 Feb 10;416(1):137-47. doi: 10.1016/j.jmb.2011.12.012. Epub 2011Dec 13. PubMed

Structural characterization of a D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp.bulgaricus Holton, S.J., Anandhakrishnan, M., Geerlof, A. & Wilmanns, M. Journal of Structural Biology (2012), doi:http://dx.doi.org/10.1016/j.jsb.2012.10.009

Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex. Williams, C., van den Berg, M., Panjikar, S., Stanley, W.A., Distel, B. & Wilmanns, M. EMBO J. 2011 Nov 15. doi: 10.1038/emboj.2011.411. PubMed

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Knoll, R., Linke, W.A., Zou, P., Miocic, S., Kostin, S., Buyandelger, B., Ku, C.H., Neef, S., Bug, M., Schafer, K., Knoll, G., Felkin, L.E., Wessels, J., Toischer, K., Hagn, F., Kessler, H., Didie, M., Quentin, T., Maier, L.S., Teucher, N., Unsold, B., Schmidt, A., Birks, E.J., Gunkel, S., Lang, P., Granzier, H., Zimmermann, W.H., Field, L.J., Faulkner, G., Dobbelstein, M., Barton, P.J., Sattler, M., Wilmanns, M. & Chien, K.R. Circ Res. 2011 Sep 16;109(7):758-69. Epub 2011 Jul 28. PubMed

Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin. Berkemeier, F., Bertz, M., Xiao, S., Pinotsis, N., Wilmanns, M., Grater, F. & Rief, M. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14139-44. Epub 2011 Aug 8. PubMed

Structural features of peroxisomal catalase from the yeast Hansenula polymorpha. Pena-Soler, E., Vega, M.C., Wilmanns, M. & Williams, C. Acta Crystallogr D Biol Crystallogr. 2011 Aug;67(Pt 8):690-8. Epub 2011Jul 12. PubMed

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: A benchmarking study. Busso, D., Peleg, Y., Heidebrecht, T., Romier, C., Jacobovitch, Y., Dantes, A., Salim, L., Troesch, E., Schuetz, A., Heinemann, U., Folkers, G.E., Geerlof, A., Wilmanns, M., Polewacz, A., Quedenau, C., Bussow, K., Adamson, R., Blagova, E., Walton, J., Cartwright, J.L., Bird, L.E., Owens, R.J., Berrow, N.S., Wilson, K.S., Sussman, J.L., Perrakis, A. & Celie, P.H. J Struct Biol. 2011 Aug;175(2):159-70. Epub 2011 Mar 5. PubMed

Rapid development of genetically encoded FRET reporters. Piljic, A., de Diego, I., Wilmanns, M. & Schultz, C. ACS Chem Biol. 2011 Jul 15;6(7):685-91. Epub 2011 Apr 28. PubMed

Related (betaalpha)8-barrel proteins in histidine and tryptophan biosynthesis: a paradigm to study enzyme evolution. List, F., Sterner, R. & Wilmanns, M. Chembiochem. 2011 Jul 4;12(10):1487-94. doi: 10.1002/cbic.201100082. Epub2011 Jun 8. PubMed

Structural insights into transcription complexes. Berger, I., Blanco, A.G., Boelens, R., Cavarelli, J., Coll, M., Folkers, G.E., Nie, Y., Pogenberg, V., Schultz, P., Wilmanns, M., Moras, D. & Poterszman, A. J Struct Biol. 2011 May 6. PubMed

The progress made in determining the Mycobacterium tuberculosis structural proteome. Ehebauer, M.T., Wilmanns, M. Proteomics 2011, Accepted manuscript online: 6 APR 2011, DOI: 10.1002/pmic.201000787
Link

The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition. Williams, C.P., Schueller, N., Thompson, C.A., van den Berg, M., Van Haren, S.D., Erdmann, R., Bond, C.S., Distel, B., Schliebs, W., Wilmanns, M. & Stanley, W.A. BMC Biochem. 2011 Mar 4;12:12. PubMed

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis. Due, A.V., Kuper, J., Geerlof, A., von Kries, J.P. & Wilmanns, M. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3554-9. Epub 2011 Feb 14. PubMed

Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1deltaC expression strain. Noens, E.E., Williams, C., Anandhakrishnan, M., Poulsen, C., Ehebauer, M.T. & Wilmanns, M. BMC Biotechnol. 2011 Mar 25;11(1):27. PubMed

Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development. Chen, Z., Wilmanns, M. & Zeng, A.P. Trends Biotechnol. 2010 Oct;28(10):534-42. Epub 2010 Aug 19. PubMed

The peroxisomal receptor Pex19p forms a helical mPTS recognition domain. Schueller, N., Holton, S.J., Fodor, K., Milewski, M., Konarev, P., Stanley, W.A., Wolf, J., Erdmann, R., Schliebs, W., Song, Y.H. & Wilmanns, M. EMBO J. 2010 Aug 4;29(15):2491-500. Epub 2010 Jun 8. PubMed

Proteome-wide identification of mycobacterial pupylation targets. Poulsen, C., Akhter, Y., Jeon, A.H., Schmitt-Ulms, G., Meyer, H.E., Stefanski, A., Stuhler, K., Wilmanns, M. & Song, Y.H. Mol Syst Biol. 2010 Jul 13;6:386. PubMed

Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin. Sauer, F., Vahokoski, J., Song, Y.H. & Wilmanns, M. EMBO Rep. 2010 Jul;11(7):534-40. Epub 2010 May 21. PubMed

Highlight: of systems and structures. Heinz, D.W., Betzel, C. & Wilmanns, M. Biol Chem. 2010 Jul;391(7):717-8. PubMed

Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure. Poulsen, C., Holton, S., Geerlof, A., Wilmanns, M. & Song, Y.H. FEBS Lett. 2010 Feb 19;584(4):669-74. Epub 2010 Jan 18. PubMed

Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex. de Diego, I., Kuper, J., Bakalova, N., Kursula, P. & Wilmanns, M. Sci Signal. 2010 Jan 26;3(106):ra6. PubMed

Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering. Shiozawa, K., Konarev, P.V., Neufeld, C., Wilmanns, M. & Svergun, D.I. J Biol Chem. 2009 Sep 11;284(37):25334-42. Epub 2009 Jul 6. PubMed

The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Bertz, M., Wilmanns, M. & Rief, M. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13307-133310. Epub 2009 Jul21. PubMed

Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactions. Fernandez-Ballester, G., Beltrao, P., Gonzalez, J.M., Song, Y.H., Wilmanns, M., Valencia, A. & Serrano, L. J Mol Biol. 2009 May 15;388(4):902-16. Epub 2009 Mar 24. PubMed

Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples. Bertini, I., Kursula, P., Luchinat, C., Parigi, G., Vahokoski, J., Wilmanns, M. & Yuan, J. J Am Chem Soc. 2009 Apr 15;131(14):5134-44. PubMed

Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. Neufeld, C., Filipp, F.V., Simon, B., Neuhaus, A., Schuller, N., David, C., Kooshapur, H., Madl, T., Erdmann, R., Schliebs, W., Wilmanns, M. & Sattler, M. EMBO J. 2009 Mar 18;28(6):745-54. Epub 2009 Feb 5. PubMed

Mechanical network in titin immunoglobulin from force distribution analysis. Stacklies, W., Vega, M.C., Wilmanns, M. & Grater, F. PLoS Comput Biol. 2009 Mar;5(3):e1000306. Epub 2009 Mar 13. PubMed

Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis. Ruggiero, A., Tizzano, B., Pedone, E., Pedone, C., Wilmanns, M. & Berisio, R. J Mol Biol. 2009 Jan 9;385(1):153-62. Epub 2008 Oct 22. PubMed

Terminal assembly of sarcomeric filaments by intermolecular beta-sheet formation. Pinotsis, N., Abrusci, P., Djinovic-Carugo, K. & Wilmanns, M. Trends Biochem Sci. 2009 Jan;34(1):33-9. Epub 2008 Nov 6. PubMed

Protein assemblies with palindromic structure motifs. Pinotsis, N. & Wilmanns, M. Cell Mol Life Sci. 2008 Oct;65(19):2953-6. PubMed

Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization. Lamber, E.P., Vanhille, L., Textor, L.C., Kachalova, G.S., Sieweke, M.H. & Wilmanns, M. EMBO J. 2008 Jul 23;27(14):2006-17. Epub 2008 Jun 19. PubMed

Bimolecular fluorescence complementation in structural biology. Song, Y.H. & Wilmanns, M. Methods. 2008 Jul;45(3):219-22. Epub 2008 Jul 9. PubMed

Probing lipid- and drug-binding domains with fluorescent dyes. Black, S.L., Stanley, W.A., Filipp, F.V., Bhairo, M., Verma, A., Wichmann, O., Sattler, M., Wilmanns, M. & Schultz, C. Bioorg Med Chem. 2008 Feb 1;16(3):1162-73. Epub 2007 Nov 19. PubMed

Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. Pinotsis, N., Lange, S., Perriard, J.C., Svergun, D.I. & Wilmanns, M. EMBO J. 2008 Jan 9;27(1):253-64. Epub 2007 Dec 6. PubMed

Low resolution structural models of the basic helix-loop-helix leucine zipper domain of upstream stimulatory factor 1 and its complexes with DNA from small angle X-ray scattering data. Lamber, E.P., Wilmanns, M. & Svergun, D.I. Biophys J. 2008 Jan 1;94(1):193-7. Epub 2007 Sep 7. PubMed

High-resolution Structural Analysis of Mammalian Profilin 2a Complex Formation with Two Physiological Ligands: The Formin Homology 1 Domain of mDia1 and the Proline-rich Domain of VASP. Kursula, P., Kursula, I., Massimi, M., Song, Y.H., Downer, J., Stanley, W.A., Witke, W. & Wilmanns, M. J Mol Biol. 2007 Oct 24;. PubMed

Protein translocation into peroxisomes by ring-shaped import receptors. Stanley, W.A., Fodor, K., Marti-Renom, M.A., Schliebs, W. & Wilmanns, M. FEBS Lett. 2007 Oct 16;581(25):4795-802. Epub 2007 Sep 11. PubMed

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis. Ruggiero, A., Tizzano, B., Geerlof, A., Pedone, E., Pedone, C., Wilmanns, M. & Berisio, R. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt10):870-3. Epub 2007 Sep 19. PubMed

Second SH3 Domain of Ponsin Solved from Powder Diffraction. Margiolaki, I., Wright, J.P., Wilmanns, M., Fitch, A.N. & Pinotsis, N. J Am Chem Soc. 2007 Sep 5;. PubMed

Expression, purification, crystallization and preliminary crystallographic analysis of the mouse transcription factor MafB in complex with its DNA-recognition motif Cmare. Textor, L.C., Wilmanns, M. & Holton, S.J. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt8):657-61. Epub 2007 Jul 7. PubMed

Structure-based approaches to drug discovery against tuberculosis. Holton, S.J., Weiss, M.S., Tucker, P.A. & Wilmanns, M. Curr Protein Pept Sci. 2007 Aug;8(4):365-75. PubMed

Paxillin and ponsin interact in nascent costameres of muscle cells. Gehmlich, K., Pinotsis, N., Hayess, K., van der Ven, P.F., Milting, H., El Banayosy, A., Korfer, R., Wilmanns, M., Ehler, E. & Furst, D.O. J Mol Biol. 2007 Jun 8;369(3):665-82. Epub 2007 Mar 24. PubMed

Understanding a mechanism of organic cosolvent inactivation in heme monooxygenase P450 BM-3. Kuper, J., Wong, T.S., Roccatano, D., Wilmanns, M. & Schwaneberg, U. J Am Chem Soc. 2007 May 9;129(18):5786-7. Epub 2007 Apr 13. PubMed

Rigid Conformation of an Immunoglobulin Domain Tandem Repeat in the A-band of the Elastic Muscle Protein Titin. Muller, S., Lange, S., Gautel, M. & Wilmanns, M. J Mol Biol. 2007 May 25;. PubMed

Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay. Stanley, W.A., Versluis, K., Schultz, C., Heck, A.J. & Wilmanns, M. Arch Biochem Biophys. 2007 May 1;461(1):50-8. Epub 2007 Mar 15. PubMed

Octameric alcohol oxidase dissociates into stable, soluble monomers upon incubation with dimethylsulfoxide. Visser, N.V., Wang, D., Stanley, W.A., Groves, M.R., Wilmanns, M., Veenhuis, M. & van der Klei, I.J. Arch Biochem Biophys. 2007 Mar 15;459(2):208-13. Epub 2007 Jan 23. PubMed

On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Mueller-Dieckmann, C., Panjikar, S., Schmidt, A., Mueller, S., Kuper, J., Geerlof, A., Wilmanns, M., Singh, R.K., Tucker, P.A. & Weiss, M.S. Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):366-80. Epub 2007Feb 21. PubMed

A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding. Stanley, W.A., Pursiainen, N.V., Garman, E.F., Juffer, A.H., Wilmanns, M. & Kursula, P. BMC Struct Biol. 2007 Apr 11;7:24. PubMed

Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p. Stanley, W.A., Filipp, F.V., Kursula, P., Schuller, N., Erdmann, R., Schliebs, W., Sattler, M. & Wilmanns, M. Mol Cell. 2006 Dec 8;24(5):653-63. PubMed

Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis. Holton, S.J., King-Scott, S., Nasser Eddine, A., Kaufmann, S.H. & Wilmanns, M. FEBS Lett. 2006 Dec 22;580(30):6898-902. Epub 2006 Nov 30. PubMed

Dynamic architecture of the peroxisomal import receptor Pex5p. A Stanley, W. & Wilmanns, M. Biochim Biophys Acta. 2006 Dec;1763(12):1592-8. Epub 2006 Nov 10. PubMed

Cellular target genes of Epstein-Barr virus nuclear antigen 2. Maier, S., Staffler, G., Hartmann, A., Hock, J., Henning, K., Grabusic, K., Mailhammer, R., Hoffmann, R., Wilmanns, M., Lang, R., Mages, J. & Kempkes, B. J Virol. 2006 Oct;80(19):9761-71. PubMed

The impact of protein characterization in structural proteomics. Geerlof, A., Brown, J., Coutard, B., Egloff, M.P., Enguita, F.J., Fogg, M.J., Gilbert, R.J., Groves, M.R., Haouz, A., Nettleship, J.E., Nordlund, P., Owens, R.J., Ruff, M., Sainsbury, S., Svergun, D.I. & Wilmanns, M. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1125-36. Epub 2006Sep 19. PubMed

Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE. Alzari, P.M., Berglund, H., Berrow, N.S., Blagova, E., Busso, D., Cambillau, C., Campanacci, V., Christodoulou, E., Eiler, S., Fogg, M.J., Folkers, G., Geerlof, A., Hart, D., Haouz, A., Herman, M.D., Macieira, S., Nordlund, P., Perrakis, A., Quevillon-Cheruel, S., Tarandeau, F., van Tilbeurgh, H., Unger, T., Luna-Vargas, M.P., Velarde, M., Wilmanns, M. & Owens, R.J. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1103-13. Epub 2006Sep 19. PubMed

Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. Pinotsis, N., Petoukhov, M., Lange, S., Svergun, D., Zou, P., Gautel, M. & Wilmanns, M. J Struct Biol. 2006 Aug;155(2):239-50. Epub 2006 Apr 27. PubMed

The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Ma, Q., Zhao, X., Eddine, A.N., Geerlof, A., Li, X., Cronan, J.E., Kaufmann, S.H. & Wilmanns, M. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8662-7. Epub 2006 May 30. PubMed

The structure of the 2[4Fe-4S] ferredoxin from Pseudomonas aeruginosa at 1.32-A resolution: comparison with other high-resolution structures of ferredoxins and contributing structural features to reduction potential values. Giastas, P., Pinotsis, N., Efthymiou, G., Wilmanns, M., Kyritsis, P., Moulis, J.M. & Mavridis, I.M. J Biol Inorg Chem. 2006 Jun;11(4):445-58. Epub 2006 Apr 5. PubMed

Mechanical strength of the titin Z1Z2-telethonin complex. Lee, E.H., Gao, M., Pinotsis, N., Wilmanns, M. & Schulten, K. Structure. 2006 Mar;14(3):497-509. PubMed

Crystal structure of the PB1 domain of NBR1. Muller, S., Kursula, I., Zou, P. & Wilmanns, M. FEBS Lett. 2006 Jan 9;580(1):341-4. Epub 2005 Dec 19. PubMed

Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Zou, P., Pinotsis, N., Lange, S., Song, Y.H., Popov, A., Mavridis, I., Mayans, O.M., Gautel, M. & Wilmanns, M. Nature. 2006 Jan 12;439(7073):229-33. PubMed

Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. Kim, C., Gajendran, N., Mittrucker, H.W., Weiwad, M., Song, Y.H., Hurwitz, R., Wilmanns, M., Fischer, G. & Kaufmann, S.H. Proc Natl Acad Sci U S A 2005 Mar 29;102(13):4830-5. Epub 2005 Mar 16. PubMed

Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. Vega, M.C., Zou, P., Fernandez, F.J., Murphy, G.E., Sterner, R., Popov, A. & Wilmanns, M. Mol Microbiol 2005 Feb;55(3):675-86. PubMed

Two-fold repeated (betaalpha)(4) half-barrels may provide a molecular tool for dual substrate specificity. Kuper, J., Doenges, C. & Wilmanns, M. EMBO Rep 2005 Feb;6(2):134-9. PubMed

Molecular crystallography. Wilmanns, M. & Weiss, M.S. (2005). In "Encyclopedia of Condensed Matter Physics", Bassani, G., Liedl, G. & Wyder, P. (eds.), pp.453-458, Academic Press

Structural basis of the ATP phosphoribosyltransferase (HisG)2-(HisZ)4-(HisG)2 hetero-oligomeric complex from Thermotoga maritima. Vega, M.C., Fernandez, F.J., Murphy, G., Zou, P., Popov, A. & Wilmanns, M. Mol. Microbiol. 2005 (55) 675-686

Synergistic use of synchrotron radiation techniques for biological samples in solution: a case study on protein-ligand recognition by the peroxisomal import receptor Pex5p. Stanley, W.A., Sokolova, A., Brown, A., Clarke, D.T., Wilmanns, M. & Svergun, D.I. J Synchrotron Radiat 2004 Nov 1;11(Pt 6):490-6. Epub 2004 Oct 22. PubMed

Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. Barabas, O., Pongracz, V., Kovari, J., Wilmanns, M. & Vertessy, B.G. J Biol Chem 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PubMed

Combinatorial control of gene expression. Remenyi, A., Scholer, H.R. & Wilmanns, M. Nat Struct Mol Biol 2004 Sep;11(9):812-5. PubMed

Structural studies of the catalytic reaction pathway of a hyperthermophilic histidinol-phosphate aminotransferase. Fernandez, F.J., Vega, M.C., Lehmann, F., Sandmeier, E., Gehring, H., Christen, P. & Wilmanns, M. J Biol Chem 2004 Mar 8;. PubMed

Solvation in protein folding analysis: combination of theoretical and experimental approaches. Fernandez-Escamilla, A.M., Cheung, M.S., Vega, M.C., Wilmanns, M., Onuchic, J.N. & Serrano, L. Proc Natl Acad Sci U S A 2004 Mar 2;101(9):2834-9. Epub 2004 Feb 20. PubMed

Adaptation of Class-13 alpha-Amylases to Diverse Living Conditions. Linden, A. & Wilmanns, M. Chembiochem 2004 Feb 6;5(2):231-9. PubMed

Structure of the bisubstrate isomerase priA: a smart solution to exploit ancestral half-barrels for dual substrate specifity? Kuper, J., Doenges, C. & Wilmanns, M. EMBO Reports 2004 134-139

Evolutionary markers in the (beta/alpha)(8)-barrel fold. Vega, M.C., Lorentzen, E., Linden, A. & Wilmanns, M. Curr Opin Chem Biol 2003 Dec;7(6):694-701. PubMed

Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Remenyi, A., Lins, K., Nissen, L.J., Reinbold, R., Scholer, H.R. & Wilmanns, M. Genes Dev 2003 Aug 15;17(16):2048-59. PubMed

OBF1 enhances transcriptional potential of Oct1. Lins, K., Remenyi, A., Tomilin, A., Massa, S., Wilmanns, M., Matthias, P. & Scholer, H.R. EMBO J 2003 May 1;22(9):2188-98. PubMed

Differential Regulation of a Hyperthermophilic alpha -Amylase with a Novel (Ca,Zn) Two-metal Center by Zinc. Linden, A., Mayans, O., Meyer-Klaucke, W., Antranikian, G. & Wilmanns, M. J Biol Chem 2003 Mar 14;278(11):9875-84. PubMed

Solution scattering suggests cross-linking function of telethonin in the complex with titin. Zou, P., Gautel, M., Geerlof, A., Wilmanns, M., Koch, M.H. & Svergun, D.I. J Biol Chem 2003 Jan 24;278(4):2636-44. PubMed

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology. Terwilliger, T.C., Park, M.S., Waldo, G.S., Berendzen, J., Hung, L.W., Kim, C.Y., Smith, C.V., Sacchettini, J.C., Bellinzoni, M., Bossi, R., De Rossi, E., Mattevi, A., Milano, A., Riccardi, G., Rizzi, M., Roberts, M.M., Coker, A.R., Fossati, G., Mascagni, P., Coates, A.R., Wood, S.P., Goulding, C.W., Apostol, M.I., Anderson, D.H., Gill, H.S., Eisenberg, D.S., Taneja, B., Mande, S., Pohl, E., Lamzin, V., Tucker, P., Wilmanns, M., Colovos, C., Meyer-Klaucke, W., Munro, A.W., McLean, K.J., Marshall, K.R., Leys, D., Yang, J.K., Yoon, H.J., Lee, B.I., Lee, M.G., Kwak, J.E., Han, B.W., Lee, J.Y., Baek, S.H., Suh, S.W., Komen, M.M., Arcus, V.L., Baker, E.N., Lott, J.S., Jacobs W, J.r, Alber, T. & Rupp, B. Tuberculosis (Edinb) 2003;83(4):223-49. PubMed

Steered molecular dynamics studies of titin i1 domain unfolding. Gao, M., Wilmanns, M. & Schulten, K. Biophys J 2002 Dec;83(6):3435-45. PubMed

Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. Paavilainen, V.O., Merckel, M.C., Falck, S., Ojala, P.J., Pohl, E., Wilmanns, M. & Lappalainen, P. J Biol Chem 2002 Nov 8;277(45):43089-95. PubMed

Differential activity by DNA-induced quarternary structures of POU transcription factors. Remenyi, A., Tomilin, A., Scholer, H.R. & Wilmanns, M. Biochem Pharmacol 2002 Sep;64(5-6):979-84. PubMed

Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry. Mayans, O., Ivens, A., Nissen, L.J., Kirschner, K. & Wilmanns, M. EMBO J 2002 Jul 1;21(13):3245-54. PubMed

The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax. Pohl, E., Brunner, N., Wilmanns, M. & Hensel, R. J Biol Chem 2002 May 31;277(22):19938-45. PubMed

Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis. Fazi, B., Cope, M.J., Douangamath, A., Ferracuti, S., Schirwitz, K., Zucconi, A., Drubin, D.G., Wilmanns, M., Cesareni, G. & Castagnoli, L. J Biol Chem 2002 Feb 15;277(7):5290-8. PubMed

Stabilization of a ([beta][alpha])8-barrel protein by an engineered disulfide bridge. Ivens, A., Mayans, O., Szadkowski, H., Jurgens, C., Wilmanns, M. & Kirschner, K. Eur J Biochem 2002 Feb;269(4):1145-1153. PubMed

Structural Genomics in Europe and Beyond - Shifting Scientific Directions at EMBL Hamburg Wilmanns, M. Acta Physica Polonica A, 101, 635-646

Integrated Structural Genomics in Europe Wilmanns, M. Gene Funct. Dis. 3, 18-24

Crystallization of redox-insensitive Oct1 POU domain with different DNA-response elements. Remenyi, A., Pohl, E., Scholer, H.R. & Wilmanns, M. Acta Crystallogr D Biol Crystallogr 2001 Nov;57(Pt 11):1634-8. PubMed

Matti Saraste (1949-2001). Wilmanns, M. Structure (Camb) 2001 Sep;9(9):769-70. PubMed

Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. Remenyi, A., Tomilin, A., Pohl, E., Lins, K., Philippsen, A., Reinbold, R., Scholer, H.R. & Wilmanns, M. Mol Cell 2001 Sep;8(3):569-80. PubMed

Divergent evolution of (betaalpha)8-barrel enzymes. Henn-Sax, M., Hocker, B., Wilmanns, M. & Sterner, R. Biol Chem 2001 Sep;382(9):1315-20. PubMed

Stability, catalytic versatility and evolution of the (beta alpha)(8)-barrel fold. Hocker, B., Jurgens, C., Wilmanns, M. & Sterner, R. Curr Opin Biotechnol 2001 Aug;12(4):376-81. PubMed

Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin. Mayans, O., Wuerges, J., Canela, S., Gautel, M. & Wilmanns, M. Structure (Camb) 2001 Apr 4;9(4):331-40. PubMed

Purification, characterization and crystallization of thermostable anthranilate phosphoribosyltransferase from Sulfolobus solfataricus. Ivens, A., Mayans, O., Szadkowski, H., Wilmanns, M. & Kirschner, K. Eur J Biochem 2001 Apr;268(8):2246-52. PubMed

Atomic resolution structure of a mutant of the spectrin SH3 domain. Berisio, R., Viguera, A., Serrano, L. & Wilmanns, M. Acta Crystallogr D Biol Crystallogr 2001 Feb;57(Pt 2):337-40. PubMed

Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. Tomilin, A., Remenyi, A., Lins, K., Bak, H., Leidel, S., Vriend, G., Wilmanns, M. & Scholer, H.R. Cell 2000 Dec 8;103(6):853-64. PubMed

Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion. Lang, D., Thoma, R., Henn-Sax, M., Sterner, R. & Wilmanns, M. Science 2000 Sep 1;289(5484):1546-50. PubMed

Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways. Jurgens, C., Strom, A., Wegener, D., Hettwer, S., Wilmanns, M. & Sterner, R. Proc Natl Acad Sci U S A 2000 Aug 29;97(18):9925-30. PubMed

Activation of calcium/calmodulin regulated kinases. Wilmanns, M., Gautel, M. & Mayans, O. Cell Mol Biol (Noisy-le-grand) 2000 Jul;46(5):883-94. PubMed

Future structural biology applications with a free-electron laser - more than wild dreams? Wilmanns, M. J Synchrotron Radiat. 2000 Jan;7(Pt 1):41-6. Epub 2000 Jan 1. PubMed

Crystallization and preliminary X-ray diffraction analysis of the NAD- dependent non--phosphorylating GAPDH of the hyperthermophilic archaeon thermoproteus tenax. Brunner, N.A., Lang, D.A., Wilmanns, M. & Hensel, R. Acta Crystallogr D Biol Crystallogr 2000 Jan;56 (Pt 1):89-91 PubMed

Activation of calcium/calmodulin regulated kinases. Wilmanns, M., Gautel, M. & Mayans, O. Cell. Mol. Biol. (Noisy-le-Grand) 2000 46 883-894

The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications. Knochel, T., Ivens, A., Hester, G., Gonzalez, A., Bauerle, R., Wilmanns, M., Kirschner, K. & Jansonius, J.N. Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9479-84 PubMed

Efficient expression, purification and crystallisation of two hyperthermostable enzymes of histidine biosynthesis. Thoma, R., Obmolova, G., Lang, D.A., Schwander, M., Jeno, P., Sterner, R. & Wilmanns, M. FEBS Lett 1999 Jul 2;454(1-2):1-6 PubMed

Thermodynamic analysis of alpha-spectrin SH3 and two of its circular permutants with different loop lengths: discerning the reasons for rapid folding in proteins. Martinez, J.C., Viguera, A.R., Berisio, R., Wilmanns, M., Mateo, P.L., Filimonov, V.V. & Serrano, L. Biochemistry 1999 Jan 12;38(2):549-59 PubMed

Regulation von Proteinkinasen der MLCK-Familie. Wilmanns, M. & Gautel, M. Biospektrum 1999 5 198-201

X-ray analysis of protein crystals with thin plate morphology. Mayans, O. & Wilmanns, M. J. Synchr. Rad. 1999 6 1016-1020

Structural basis for activation of the titin kinase domain during myofibrillogenesis Mayans, O., van der Ven, P.F., Wilm, M., Mues, A., Young, P., Furst, D.O., Wilmanns, M. & Gautel, M. Nature 1998 Oct 29 395(6705) 863-869 PubMed

Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions. Pisabarro, M.T., Serrano, L. & Wilmanns, M. J Mol Biol 1998 Aug 21;281(3):513-21. PubMed

Different folding transition states may result in the same native structure. Viguera, A.R., Serrano, L. & Wilmanns, M. Nat Struct Biol 1996 Oct;3(10):874-80 PubMed

Structure of the binding site for inositol phosphates in a PH domain. Hyvonen, M., Macias, M.J., Nilges, M., Oschkinat, H., Saraste, M. & Wilmanns, M. EMBO J 1995 Oct 2;14(19):4676-85 PubMed

Inverse protein folding by the residue pair preference profile method: estimating the correctness of alignments of structurally compatible sequences. Wilmanns, M. & Eisenberg, D. Protein Eng 1995 Jul;8(7):627-39. PubMed

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides. Musacchio, A., Saraste, M. & Wilmanns, M. Nat Struct Biol 1994 Aug;1(8):546-51. PubMed