Top image

Staff at EMBL


Dr. Matthias Wilmanns

Head of Outstation and Senior Scientist
Wilmanns Group

EMBL Hamburg c/o DESY, Notkestraße 85, 22603 Hamburg, Germany

E-mail: send a mail


PhD 1990, University of Basel.
Postdoctoral research at the University of California, Los Angeles.
Group leader at EMBL Heidelberg 1993-1997.
Head of EMBL Hamburg since 1997.
Research Director of the Center for Structural Systems Biology (CSSB) since 2014.


Total: 144 publication(s)


Fodor K, Wolf J, Reglinski K, Passon DM, Lou Y, Schliebs W, Erdmann R, Wilmanns M. (2014)
Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes.
Traffic doi:10.1111/tra.12238
Europe PMC | doi

Das U, Pogenberg V, Subhramanyam UK, Wilmanns M, Gourinath S, Srinivasan A. (2014)
Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly.
J. Struct. Biol. 188(3):249-258. doi:10.1016/j.jsb.2014.10.002
Europe PMC | doi

Korotkova N, Freire D, Phan TH, Ummels R, Creekmore CC, Evans TJ, Wilmanns M, Bitter W, Parret AH, Houben EN, Korotkov KV. (2014)
Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer.
Mol. Microbiol. 94(2):367-382. doi:10.1111/mmi.12770
Europe PMC | doi

Kravchenko IV, Furalyov VA, Chatziefthimiou S, Wilmanns M, Popov VO. (2014)
Induction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins
Mol. Cell. Endocrinol. doi:10.1016/j.mce.2014.08.010
Europe PMC | doi

Elleuche S, Fodor K, von der Heyde A, Klippel B, Wilmanns M, Antranikian G. (2014)
Group III alcohol dehydrogenase from Pectobacterium atrosepticum: insights into enzymatic activity and organization of the metal ion-containing region.
Appl. Microbiol. Biotechnol. 98(9):4041-4051. doi:10.1007/s00253-013-5374-z
Europe PMC | doi

Ma Q, Akhter Y, Wilmanns M, Ehebauer MT. (2014)
Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis
Protein Sci. 23(7):932-939. doi:10.1002/pro.2475
Europe PMC | doi

Pogenberg V, Consani Textor L, Vanhille L, Holton SJ, Sieweke MH, Wilmanns M. (2014)
Design of a bZip transcription factor with homo/heterodimer-induced DNA-binding preference
Structure 22(3):466-477. doi:10.1016/j.str.2013.12.017
Europe PMC | doi

Meyer C, Hoeger B, Temmerman K, Tatarek-Nossol M, Pogenberg V, Bernhagen J, Wilmanns M, Kapurniotu A, Köhn M. (2014)
Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells
ACS Chem. Biol. 9(3):769-776. doi:10.1021/cb400903u
Europe PMC | doi

Ponomarenko N, Chatziefthimiou SD, Kurkova I, Mokrushina Y, Mokrushina Y, Stepanova A, Smirnov I, Avakyan M, Bobik T, Mamedov A, Mitkevich V, Belogurov A Jr, Fedorova OS, Dubina M, Golovin A, Lamzin V, Friboulet A, Makarov AA, Wilmanns M, Gabibov A. (2014)
Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody
Acta Crystallogr. D Biol. Crystallogr. 70(Pt 3):708-719. doi:10.1107/s1399004713032446
Europe PMC | doi

Temmerman K, de Diego I, Pogenberg V, Simon B, Jonko W, Li X, Wilmanns M. (2014)
A PEF/Y substrate recognition and signature motif plays a critical role in DAPK-related kinase activity
Chem. Biol. 21(2):264-273. doi:10.1016/j.chembiol.2013.12.008
Europe PMC | doi

Wilmanns M, Svergun DI. (2014)
The 11th International Conference on Biology and Synchrotron Radiation
J Synchrotron Radiat 21(Pt 1):280-282. doi:10.1107/s1600577513030609
Europe PMC | doi

Poulsen C, Panjikar S, Holton SJ, Wilmanns M, Song YH. (2014)
WXG100 protein superfamily consists of three subfamilies and exhibits an α-helical C-terminal conserved residue pattern
PLoS ONE 9(2):e89313. doi:10.1371/journal.pone.0089313
Europe PMC | doi


Barabás O, Németh V, Bodor A, Perczel A, Rosta E, Kele Z, Zagyva I, Szabadka Z, Grolmusz VI, Wilmanns M, Vértessy BG. (2013)
Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling
Nucleic Acids Res. 41(22):10542-10555. doi:10.1093/nar/gkt756
Europe PMC | doi

Grill C, Bergsteinsdóttir K, Ogmundsdóttir MH, Pogenberg V, Schepsky A, Wilmanns M, Pingault V, Steingrímsson E. (2013)
MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function
Hum. Mol. Genet. 22(21):4357-4367. doi:10.1093/hmg/ddt285
Europe PMC | doi

Temmerman K, Simon B, Wilmanns M. (2013)
Structural and functional diversity in the activity and regulation of DAPK-related protein kinases
FEBS J. 280(21):5533-5550. doi:10.1111/febs.12384
Europe PMC | doi

Eulitz S, Sauer F, Pelissier MC, Boisguerin P, Molt S, Schuld J, Orfanos Z, Kley RA, Volkmer R, Wilmanns M, Kirfel G, van der Ven PF, Fürst DO. (2013)
Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling
Mol. Biol. Cell 24(20):3215-3226. doi:10.1091/mbc.e13-04-0202
Europe PMC | doi

Elleuche S, Fodor K, Klippel B, von der Heyde A, Wilmanns M, Antranikian G. (2013)
Structural and biochemical characterisation of a NAD⁺-dependent alcohol dehydrogenase from Oenococcus oeni as a new model molecule for industrial biotechnology applications
Appl. Microbiol. Biotechnol. 97(20):8963-8975. doi:10.1007/s00253-013-4725-0
Europe PMC | doi

Eulenburg G, Higman VA, Diehl A, Wilmanns M, Holton SJ. (2013)
Structural and biochemical characterization of Rv2140c, a phosphatidylethanolamine-binding protein from Mycobacterium tuberculosis
FEBS Lett. 587(18):2936-2942. doi:10.1016/j.febslet.2013.07.038
Europe PMC | doi

Oppici E, Fodor K, Paiardini A, Williams C, Voltattorni CB, Wilmanns M, Cellini B. (2013)
Crystal structure of the S187F variant of human liver alanine: glyoxylate [corrected] aminotransferase associated with primary hyperoxaluria type I and its functional implications
Proteins 81(8):1457-1465. doi:10.1002/prot.24300
Europe PMC | doi

Li X, Wilmanns M, Thornton J, Köhn M. (2013)
Elucidating human phosphatase-substrate networks
Sci Signal 6(275):rs10. doi:10.1126/scisignal.2003203
Europe PMC | doi

Shehzad A, Panneerselvam S, Linow M, Bocola M, Roccatano D, Mueller-Dieckmann J, Wilmanns M, Schwaneberg U. (2013)
P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation
Chem. Commun. (Camb.) 49(41):4694-4696. doi:10.1039/c3cc39076d
Europe PMC | doi

Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Araúzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Schöler HR. (2013)
A unique Oct4 interface is crucial for reprogramming to pluripotency
Nat. Cell Biol. 15(3):295-301. doi:10.1038/ncb2680
Europe PMC | doi

Holton SJ, Anandhakrishnan M, Geerlof A, Wilmanns M. (2013)
Structural characterization of a D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus
J. Struct. Biol. 181(2):179-184. doi:10.1016/j.jsb.2012.10.009
Europe PMC | doi

Williams C, van den Berg M, Stanley WA, Wilmanns M, Distel B. (2013)
A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity
Sci Rep 3:2212. doi:10.1038/srep02212
Europe PMC | doi


List F, Vega MC, Razeto A, Häger MC, Sterner R, Wilmanns M. (2012)
Catalysis uncoupling in a glutamine amidotransferase bienzyme by unblocking the glutaminase active site
Chem. Biol. 19(12):1589-1599. doi:10.1016/j.chembiol.2012.10.012
Europe PMC | doi

Pogenberg V, Ogmundsdóttir MH, Bergsteinsdóttir K, Schepsky A, Phung B, Deineko V, Milewski M, Steingrímsson E, Wilmanns M. (2012)
Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF
Genes Dev. 26(23):2647-2658. doi:10.1101/gad.198192.112
Europe PMC | doi

Burns KE, McAllister FE, Schwerdtfeger C, Mintseris J, Cerda-Maira F, Noens EE, Wilmanns M, Hubbard SR, Melandri F, Ovaa H, Gygi SP, Darwin KH. (2012)
Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase
J. Biol. Chem. 287(44):37522-37529. doi:10.1074/jbc.m112.384784
Europe PMC | doi

Kuper J, Tee KL, Wilmanns M, Roccatano D, Schwaneberg U, Wong TS. (2012)
The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68(Pt 9):1013-1017. doi:10.1107/s1744309112031570
Europe PMC | doi

Héja D, Harmat V, Fodor K, Wilmanns M, Dobó J, Kékesi KA, Závodszky P, Gál P, Pál G. (2012)
Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2
J. Biol. Chem. 287(24):20290-20300. doi:10.1074/jbc.m112.354332
Europe PMC | doi

Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M. (2012)
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties
PLoS Biol. 10(2):e1001261. doi:10.1371/journal.pbio.1001261
Europe PMC | doi

Steward A, Chen Q, Chapman RI, Borgia MB, Rogers JM, Wojtala A, Wilmanns M, Clarke J. (2012)
Two immunoglobulin tandem proteins with a linking β-strand reveal unexpected differences in cooperativity and folding pathways
J. Mol. Biol. 416(1):137-147. doi:10.1016/j.jmb.2011.12.012
Europe PMC | doi

Williams C, van den Berg M, Panjikar S, Stanley WA, Distel B, Wilmanns M. (2012)
Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex
EMBO J. 31(2):391-402. doi:10.1038/emboj.2011.411
Europe PMC | doi

Fodor K, Wolf J, Erdmann R, Schliebs W, Wilmanns M. (2012)
Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1
PLoS Biol. 10(4):e1001309. doi:10.1371/journal.pbio.1001309
Europe PMC | doi


Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR. (2011)
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart
Circ. Res. 109(7):758-769. doi:10.1161/circresaha.111.245787
Europe PMC | doi

Busso D, Peleg Y, Heidebrecht T, Romier C, Jacobovitch Y, Dantes A, Salim L, Troesch E, Schuetz A, Heinemann U, Folkers GE, Geerlof A, Wilmanns M, Polewacz A, Quedenau C, Büssow K, Adamson R, Blagova E, Walton J, Cartwright JL, Bird LE, Owens RJ, Berrow NS, Wilson KS, Sussman JL, Perrakis A, Celie PH. (2011)
Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study
J. Struct. Biol. 175(2):159-170. doi:10.1016/j.jsb.2011.03.004
Europe PMC | doi

Berkemeier F, Bertz M, Xiao S, Pinotsis N, Wilmanns M, Gräter F, Rief M. (2011)
Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin
Proc. Natl. Acad. Sci. U.S.A. 108(34):14139-14144. doi:10.1073/pnas.1105734108
Europe PMC | doi

Peña-Soler E, Vega MC, Wilmanns M, Williams C. (2011)
Structural features of peroxisomal catalase from the yeast Hansenula polymorpha
Acta Crystallogr. D Biol. Crystallogr. 67(Pt 8):690-698. doi:10.1107/s0907444911022463
Europe PMC | doi

Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE, Nie Y, Pogenberg V, Schultz P, Wilmanns M, Moras D, Poterszman A. (2011)
Structural insights into transcription complexes
J. Struct. Biol. 175(2):135-146. doi:10.1016/j.jsb.2011.04.015
Europe PMC | doi

Ehebauer MT, Wilmanns M. (2011)
The progress made in determining the Mycobacterium tuberculosis structural proteome
Proteomics 11(15):3128-3133. doi:10.1002/pmic.201000787
Europe PMC | doi

Piljić A, de Diego I, Wilmanns M, Schultz C. (2011)
Rapid development of genetically encoded FRET reporters
ACS Chem. Biol. 6(7):685-691. doi:10.1021/cb100402n
Europe PMC | doi

List F, Sterner R, Wilmanns M. (2011)
Related (βα)8-barrel proteins in histidine and tryptophan biosynthesis: a paradigm to study enzyme evolution
Chembiochem 12(10):1487-1494. doi:10.1002/cbic.201100082
Europe PMC | doi

Due AV, Kuper J, Geerlof A, von Kries JP, Wilmanns M. (2011)
Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis
Proc. Natl. Acad. Sci. U.S.A. 108(9):3554-3559. doi:10.1073/pnas.1015996108
Europe PMC | doi

Noens EE, Williams C, Anandhakrishnan M, Poulsen C, Ehebauer MT, Wilmanns M. (2011)
Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1ΔC expression strain
BMC Biotechnol. 11:27. doi:10.1186/1472-6750-11-27
Europe PMC | doi

Williams CP, Schueller N, Thompson CA, van den Berg M, Van Haren SD, Erdmann R, Bond CS, Distel B, Schliebs W, Wilmanns M, Stanley WA. (2011)
The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition
BMC Biochem. 12:12. doi:10.1186/1471-2091-12-12
Europe PMC | doi


Chen Z, Wilmanns M, Zeng AP. (2010)
Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development
Trends Biotechnol. 28(10):534-542. doi:10.1016/j.tibtech.2010.07.004
Europe PMC | doi

Schueller N, Holton SJ, Fodor K, Milewski M, Konarev P, Stanley WA, Wolf J, Erdmann R, Schliebs W, Song YH, Wilmanns M. (2010)
The peroxisomal receptor Pex19p forms a helical mPTS recognition domain
EMBO J. 29(15):2491-2500. doi:10.1038/emboj.2010.115
Europe PMC | doi

Heinz DW, Betzel C, Wilmanns M. (2010)
Highlight: of systems and structures
Biol. Chem. 391(7):717-718. doi:10.1515/bc.2010.095
Europe PMC | doi

Sauer F, Vahokoski J, Song YH, Wilmanns M. (2010)
Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin
EMBO Rep. 11(7):534-540. doi:10.1038/embor.2010.65
Europe PMC | doi

Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH. (2010)
Proteome-wide identification of mycobacterial pupylation targets
Mol. Syst. Biol. 6:386. doi:10.1038/msb.2010.39
Europe PMC | doi

Poulsen C, Holton S, Geerlof A, Wilmanns M, Song YH. (2010)
Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure
FEBS Lett. 584(4):669-674. doi:10.1016/j.febslet.2009.12.057
Europe PMC | doi

de Diego I, Kuper J, Bakalova N, Kursula P, Wilmanns M. (2010)
Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex
Sci Signal 3(106):ra6. doi:10.1126/scisignal.2000552
Europe PMC | doi


Shiozawa K, Konarev PV, Neufeld C, Wilmanns M, Svergun DI. (2009)
Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering
J. Biol. Chem. 284(37):25334-25342. doi:10.1074/jbc.m109.002311
Europe PMC | doi

Bertz M, Wilmanns M, Rief M. (2009)
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk
Proc. Natl. Acad. Sci. U.S.A. 106(32):13307-133310. doi:10.1073/pnas.0902312106
Europe PMC | doi

Fernandez-Ballester G, Beltrao P, Gonzalez JM, Song YH, Wilmanns M, Valencia A, Serrano L. (2009)
Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactions
J. Mol. Biol. 388(4):902-916. doi:10.1016/j.jmb.2009.03.038
Europe PMC | doi

Bertini I, Kursula P, Luchinat C, Parigi G, Vahokoski J, Wilmanns M, Yuan J. (2009)
Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples
J. Am. Chem. Soc. 131(14):5134-5144. doi:10.1021/ja8080764
Europe PMC | doi

Stacklies W, Vega MC, Wilmanns M, Gräter F. (2009)
Mechanical network in titin immunoglobulin from force distribution analysis
PLoS Comput. Biol. 5(3):e1000306. doi:10.1371/journal.pcbi.1000306
Europe PMC | doi

Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M. (2009)
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19
EMBO J. 28(6):745-754. doi:10.1038/emboj.2009.7
Europe PMC | doi

Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R. (2009)
Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis
J. Mol. Biol. 385(1):153-162. doi:10.1016/j.jmb.2008.10.042
Europe PMC | doi

Pinotsis N, Abrusci P, Djinović-Carugo K, Wilmanns M. (2009)
Terminal assembly of sarcomeric filaments by intermolecular beta-sheet formation
Trends Biochem. Sci. 34(1):33-39. doi:10.1016/j.tibs.2008.09.009
Europe PMC | doi


Pinotsis N, Wilmanns M. (2008)
Protein assemblies with palindromic structure motifs
Cell. Mol. Life Sci. 65(19):2953-2956. doi:10.1007/s00018-008-8265-1
Europe PMC | doi

Song YH, Wilmanns M. (2008)
Bimolecular fluorescence complementation in structural biology
Methods 45(3):219-222. doi:10.1016/j.ymeth.2008.06.015
Europe PMC | doi

Lamber EP, Vanhille L, Textor LC, Kachalova GS, Sieweke MH, Wilmanns M. (2008)
Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization
EMBO J. 27(14):2006-2017. doi:10.1038/emboj.2008.117
Europe PMC | doi

Black SL, Stanley WA, Filipp FV, Bhairo M, Verma A, Wichmann O, Sattler M, Wilmanns M, Schultz C. (2008)
Probing lipid- and drug-binding domains with fluorescent dyes
Bioorg. Med. Chem. 16(3):1162-1173. doi:10.1016/j.bmc.2007.10.080
Europe PMC | doi

Kursula P, Kursula I, Massimi M, Song YH, Downer J, Stanley WA, Witke W, Wilmanns M. (2008)
High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP
J. Mol. Biol. 375(1):270-290. doi:10.1016/j.jmb.2007.10.050
Europe PMC | doi

Lamber EP, Wilmanns M, Svergun DI. (2008)
Low resolution structural models of the basic helix-loop-helix leucine zipper domain of upstream stimulatory factor 1 and its complexes with DNA from small angle X-ray scattering data
Biophys. J. 94(1):193-197. doi:10.1529/biophysj.107.112243
Europe PMC | doi

Pinotsis N, Lange S, Perriard JC, Svergun DI, Wilmanns M. (2008)
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin
EMBO J. 27(1):253-264. doi:10.1038/sj.emboj.7601944
Europe PMC | doi


Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R. (2007)
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 10):870-873. doi:10.1107/s1744309107043217
Europe PMC | doi

Stanley WA, Fodor K, Marti-Renom MA, Schliebs W, Wilmanns M. (2007)
Protein translocation into peroxisomes by ring-shaped import receptors
FEBS Lett. 581(25):4795-4802. doi:10.1016/j.febslet.2007.09.001
Europe PMC | doi

Margiolaki I, Wright JP, Wilmanns M, Fitch AN, Pinotsis N. (2007)
Second SH3 domain of ponsin solved from powder diffraction
J. Am. Chem. Soc. 129(38):11865-11871. doi:10.1021/ja073846c
Europe PMC | doi

Textor LC, Wilmanns M, Holton SJ. (2007)
Expression, purification, crystallization and preliminary crystallographic analysis of the mouse transcription factor MafB in complex with its DNA-recognition motif Cmare
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 8):657-661. doi:10.1107/s1744309107031260
Europe PMC | doi

Müller S, Lange S, Gautel M, Wilmanns M. (2007)
Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin
J. Mol. Biol. 371(2):469-480. doi:10.1016/j.jmb.2007.05.055
Europe PMC | doi

Holton SJ, Weiss MS, Tucker PA, Wilmanns M. (2007)
Structure-based approaches to drug discovery against tuberculosis
Curr. Protein Pept. Sci. 8(4):365-375. doi:10.2174/138920307781369445
Europe PMC | doi

Gehmlich K, Pinotsis N, Hayess K, van der Ven PF, Milting H, El Banayosy A, Körfer R, Wilmanns M, Ehler E, Fürst DO. (2007)
Paxillin and ponsin interact in nascent costameres of muscle cells
J. Mol. Biol. 369(3):665-682. doi:10.1016/j.jmb.2007.03.050
Europe PMC | doi

Stanley WA, Versluis K, Schultz C, Heck AJ, Wilmanns M. (2007)
Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay
Arch. Biochem. Biophys. 461(1):50-58. doi:10.1016/
Europe PMC | doi

Kuper J, Wong TS, Roccatano D, Wilmanns M, Schwaneberg U. (2007)
Understanding a mechanism of organic cosolvent inactivation in heme monooxygenase P450 BM-3
J. Am. Chem. Soc. 129(18):5786-5787. doi:10.1021/ja067036x
Europe PMC | doi

Visser NV, Wang D, Stanley WA, Groves MR, Wilmanns M, Veenhuis M, van der Klei IJ. (2007)
Octameric alcohol oxidase dissociates into stable, soluble monomers upon incubation with dimethylsulfoxide
Arch. Biochem. Biophys. 459(2):208-213. doi:10.1016/
Europe PMC | doi

Mueller-Dieckmann C, Panjikar S, Schmidt A, Mueller S, Kuper J, Geerlof A, Wilmanns M, Singh RK, Tucker PA, Weiss MS. (2007)
On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths
Acta Crystallogr. D Biol. Crystallogr. 63(Pt 3):366-380. doi:10.1107/s0907444906055624
Europe PMC | doi

Stanley WA, Pursiainen NV, Garman EF, Juffer AH, Wilmanns M, Kursula P. (2007)
A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding
BMC Struct. Biol. 7:24. doi:10.1186/1472-6807-7-24
Europe PMC | doi


Stanley WA, Wilmanns M. (2006)
Dynamic architecture of the peroxisomal import receptor Pex5p
Biochim. Biophys. Acta 1763(12):1592-1598. doi:10.1016/j.bbamcr.2006.10.015
Europe PMC | doi

Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M. (2006)
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p
Mol. Cell 24(5):653-663. doi:10.1016/j.molcel.2006.10.024
Europe PMC | doi

Holton SJ, King-Scott S, Nasser Eddine A, Kaufmann SH, Wilmanns M. (2006)
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis
FEBS Lett. 580(30):6898-6902. doi:10.1016/j.febslet.2006.11.054
Europe PMC | doi

Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Corrondo MA, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM. (2006)
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens
Acta Crystallogr. D Biol. Crystallogr. 62(Pt 10):1196-1207. doi:10.1107/s0907444906030915
Europe PMC | doi

Maier S, Staffler G, Hartmann A, Höck J, Henning K, Grabusic K, Mailhammer R, Hoffmann R, Wilmanns M, Lang R, Mages J, Kempkes B. (2006)
Cellular target genes of Epstein-Barr virus nuclear antigen 2
J. Virol. 80(19):9761-9771. doi:10.1128/jvi.00665-06
Europe PMC | doi

Alzari PM, Berglund H, Berrow NS, Blagova E, Busso D, Cambillau C, Campanacci V, Christodoulou E, Eiler S, Fogg MJ, Folkers G, Geerlof A, Hart D, Haouz A, Herman MD, Macieira S, Nordlund P, Perrakis A, Quevillon-Cheruel S, Tarandeau F, van Tilbeurgh H, Unger T, Luna-Vargas MP, Velarde M, Willmanns M, Owens RJ. (2006)
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE
Acta Crystallogr. D Biol. Crystallogr. 62(Pt 10):1103-1113. doi:10.1107/s0907444906029775
Europe PMC | doi

Geerlof A, Brown J, Coutard B, Egloff MP, Enguita FJ, Fogg MJ, Gilbert RJ, Groves MR, Haouz A, Nettleship JE, Nordlund P, Owens RJ, Ruff M, Sainsbury S, Svergun DI, Wilmanns M. (2006)
The impact of protein characterization in structural proteomics
Acta Crystallogr. D Biol. Crystallogr. 62(Pt 10):1125-1136. doi:10.1107/s0907444906030307
Europe PMC | doi

Marino M, Zou P, Svergun D, Garcia P, Edlich C, Simon B, Wilmanns M, Muhle-Goll C, Mayans O. (2006)
The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin
Structure 14(9):1437-1447. doi:10.1016/j.str.2006.07.009
Europe PMC | doi

Pinotsis N, Petoukhov M, Lange S, Svergun D, Zou P, Gautel M, Wilmanns M. (2006)
Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus
Paper presented at the 4th Workshop on Coiled Coils, Collagen and Co-Proteins, Alpbach, AUSTRIA, SEP 11-17, 2005.J. Struct. Biol. 155(2):239-250. doi:10.1016/j.jsb.2006.03.028
Europe PMC | doi

Ma Q, Zhao X, Nasser Eddine A, Geerlof A, Li X, Cronan JE, Kaufmann SH, Wilmanns M. (2006)
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase
Proc. Natl. Acad. Sci. U.S.A. 103(23):8662-8667. doi:10.1073/pnas.0510436103
Europe PMC | doi

Giastas P, Pinotsis N, Efthymiou G, Wilmanns M, Kyritsis P, Moulis JM, Mavridis IM. (2006)
The structure of the 2[4Fe-4S] ferredoxin from Pseudomonas aeruginosa at 1.32-A resolution: comparison with other high-resolution structures of ferredoxins and contributing structural features to reduction potential values
J. Biol. Inorg. Chem. 11(4):445-458. doi:10.1007/s00775-006-0094-9
Europe PMC | doi

Mueller-Dieckmann H-J, Weiss MS, Wilmanns M. (2006)
Protein crystallization for X-ray
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine.Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine 1478-1482. doi:10.1007/3-540-29623-9_5060

Lee EH, Gao M, Pinotsis N, Wilmanns M, Schulten K. (2006)
Mechanical strength of the titin Z1Z2-telethonin complex
Structure 14(3):497-509. doi:10.1016/j.str.2005.12.005
Europe PMC | doi

Müller S, Kursula I, Zou P, Wilmanns M. (2006)
Crystal structure of the PB1 domain of NBR1
FEBS Lett. 580(1):341-344. doi:10.1016/j.febslet.2005.12.021
Europe PMC | doi

Zou P, Pinotsis N, Lange S, Song YH, Popov A, Mavridis I, Mayans OM, Gautel M, Wilmanns M. (2006)
Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk
Nature 439(7073):229-233. doi:10.1038/nature04343
Europe PMC | doi


Wilmanns M, Weiss MS. (2005)
Molecular crystallography
Encyclopedia of Condensed Matter Physics. Academic Press.Encyclopedia of Condensed Matter Physics 453-458. doi:10.1016/b0-12-369401-9/00424-1
Europe PMC | doi

Kim C, Gajendran N, Mittrücker HW, Weiwad M, Song YH, Hurwitz R, Wilmanns M, Fischer G, Kaufmann SH. (2005)
Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences
Proc. Natl. Acad. Sci. U.S.A. 102(13):4830-4835. doi:10.1073/pnas.0500508102
Europe PMC | doi

Vega MC, Zou P, Fernandez FJ, Murphy GE, Sterner R, Popov A, Wilmanns M. (2005)
Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit
Mol. Microbiol. 55(3):675-686. doi:10.1111/j.1365-2958.2004.04422.x
Europe PMC | doi

Kuper J, Doenges C, Wilmanns M. (2005)
Two-fold repeated (betaalpha)4 half-barrels may provide a molecular tool for dual substrate specificity
EMBO Rep. 6(2):134-139. doi:10.1038/sj.embor.7400330
Europe PMC | doi


Stanley WA, Sokolova A, Brown A, Clarke DT, Wilmanns M, Svergun DI. (2004)
Synergistic use of synchrotron radiation techniques for biological samples in solution: a case study on protein-ligand recognition by the peroxisomal import receptor Pex5p
J Synchrotron Radiat 11(Pt 6):490-496. doi:10.1107/s090904950402504x
Europe PMC | doi

Barabás O, Pongrácz V, Kovári J, Wilmanns M, Vértessy BG. (2004)
Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase
J. Biol. Chem. 279(41):42907-42915. doi:10.1074/jbc.m406135200
Europe PMC | doi

Reményi A, Schöler HR, Wilmanns M. (2004)
Combinatorial control of gene expression
Nat. Struct. Mol. Biol. 11(9):812-815. doi:10.1038/nsmb820
Europe PMC | doi