Wilmanns GroupPublications
Two Immunoglobulin Tandem Proteins with a Linking beta-Strand Reveal Unexpected Differences in Cooperativity and Folding Pathways.
Steward, A., Chen, Q., Chapman, R.I., Borgia, M.B., Rogers, J.M., Wojtala, A., Wilmanns, M. & Clarke, J.
J Mol Biol. 2011 Dec 13. PubMed
Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex.
Williams, C., van den Berg, M., Panjikar, S., Stanley, W.A., Distel, B. & Wilmanns, M.
EMBO J. 2011 Nov 15. doi: 10.1038/emboj.2011.411. PubMed
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
Knoll, R., Linke, W.A., Zou, P., Miocic, S., Kostin, S., Buyandelger, B., Ku, C.H., Neef, S., Bug, M., Schafer, K., Knoll, G., Felkin, L.E., Wessels, J., Toischer, K., Hagn, F., Kessler, H., Didie, M., Quentin, T., Maier, L.S., Teucher, N., Unsold, B., Schmidt, A., Birks, E.J., Gunkel, S., Lang, P., Granzier, H., Zimmermann, W.H., Field, L.J., Faulkner, G., Dobbelstein, M., Barton, P.J., Sattler, M., Wilmanns, M. & Chien, K.R.
Circ Res. 2011 Sep 16;109(7):758-69. Epub 2011 Jul 28. PubMed
Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin.
Berkemeier, F., Bertz, M., Xiao, S., Pinotsis, N., Wilmanns, M., Grater, F. & Rief, M.
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14139-44. Epub 2011 Aug 8. PubMed
Structural features of peroxisomal catalase from the yeast Hansenula polymorpha.
Pena-Soler, E., Vega, M.C., Wilmanns, M. & Williams, C.
Acta Crystallogr D Biol Crystallogr. 2011 Aug;67(Pt 8):690-8. Epub 2011Jul 12. PubMed
Expression of protein complexes using multiple Escherichia coli protein co-expression systems: A benchmarking study.
Busso, D., Peleg, Y., Heidebrecht, T., Romier, C., Jacobovitch, Y., Dantes, A., Salim, L., Troesch, E., Schuetz, A., Heinemann, U., Folkers, G.E., Geerlof, A., Wilmanns, M., Polewacz, A., Quedenau, C., Bussow, K., Adamson, R., Blagova, E., Walton, J., Cartwright, J.L., Bird, L.E., Owens, R.J., Berrow, N.S., Wilson, K.S., Sussman, J.L., Perrakis, A. & Celie, P.H.
J Struct Biol. 2011 Aug;175(2):159-70. Epub 2011 Mar 5. PubMed
Rapid development of genetically encoded FRET reporters.
Piljic, A., de Diego, I., Wilmanns, M. & Schultz, C.
ACS Chem Biol. 2011 Jul 15;6(7):685-91. Epub 2011 Apr 28. PubMed
Related (betaalpha)8-barrel proteins in histidine and tryptophan biosynthesis: a paradigm to study enzyme evolution.
List, F., Sterner, R. & Wilmanns, M.
Chembiochem. 2011 Jul 4;12(10):1487-94. doi: 10.1002/cbic.201100082. Epub2011 Jun 8. PubMed
Structural insights into transcription complexes.
Berger, I., Blanco, A.G., Boelens, R., Cavarelli, J., Coll, M., Folkers, G.E., Nie, Y., Pogenberg, V., Schultz, P., Wilmanns, M., Moras, D. & Poterszman, A.
J Struct Biol. 2011 May 6. PubMed
The progress made in determining the Mycobacterium tuberculosis structural proteome.
Ehebauer, M.T., Wilmanns, M.
Proteomics 2011, Accepted manuscript online: 6 APR 2011, DOI: 10.1002/pmic.201000787
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The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.
Williams, C.P., Schueller, N., Thompson, C.A., van den Berg, M., Van Haren, S.D., Erdmann, R., Bond, C.S., Distel, B., Schliebs, W., Wilmanns, M. & Stanley, W.A.
BMC Biochem. 2011 Mar 4;12:12. PubMed
Improved mycobacterial protein production using a Mycobacterium smegmatis groEL1deltaC expression strain.
Noens, E.E., Williams, C., Anandhakrishnan, M., Poulsen, C., Ehebauer, M.T. & Wilmanns, M.
BMC Biotechnol. 2011 Mar 25;11(1):27. PubMed
Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis.
Due, A.V., Kuper, J., Geerlof, A., von Kries, J.P. & Wilmanns, M.
Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3554-9. Epub 2011 Feb 14. PubMed
Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development.
Chen, Z., Wilmanns, M. & Zeng, A.P.
Trends Biotechnol. 2010 Oct;28(10):534-42. Epub 2010 Aug 19. PubMed
The peroxisomal receptor Pex19p forms a helical mPTS recognition domain.
Schueller, N., Holton, S.J., Fodor, K., Milewski, M., Konarev, P., Stanley, W.A., Wolf, J., Erdmann, R., Schliebs, W., Song, Y.H. & Wilmanns, M.
EMBO J. 2010 Aug 4;29(15):2491-500. Epub 2010 Jun 8. PubMed
Proteome-wide identification of mycobacterial pupylation targets.
Poulsen, C., Akhter, Y., Jeon, A.H., Schmitt-Ulms, G., Meyer, H.E., Stefanski, A., Stuhler, K., Wilmanns, M. & Song, Y.H.
Mol Syst Biol. 2010 Jul 13;6:386. PubMed
Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.
Sauer, F., Vahokoski, J., Song, Y.H. & Wilmanns, M.
EMBO Rep. 2010 Jul;11(7):534-40. Epub 2010 May 21. PubMed
Highlight: of systems and structures.
Heinz, D.W., Betzel, C. & Wilmanns, M.
Biol Chem. 2010 Jul;391(7):717-8. PubMed
Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure.
Poulsen, C., Holton, S., Geerlof, A., Wilmanns, M. & Song, Y.H.
FEBS Lett. 2010 Feb 19;584(4):669-74. Epub 2010 Jan 18. PubMed
Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex.
de Diego, I., Kuper, J., Bakalova, N., Kursula, P. & Wilmanns, M.
Sci Signal. 2010 Jan 26;3(106):ra6. PubMed
Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering.
Shiozawa, K., Konarev, P.V., Neufeld, C., Wilmanns, M. & Svergun, D.I.
J Biol Chem. 2009 Sep 11;284(37):25334-42. Epub 2009 Jul 6. PubMed
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk.
Bertz, M., Wilmanns, M. & Rief, M.
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13307-133310. Epub 2009 Jul21. PubMed
Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactions.
Fernandez-Ballester, G., Beltrao, P., Gonzalez, J.M., Song, Y.H., Wilmanns, M., Valencia, A. & Serrano, L.
J Mol Biol. 2009 May 15;388(4):902-16. Epub 2009 Mar 24. PubMed
Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples.
Bertini, I., Kursula, P., Luchinat, C., Parigi, G., Vahokoski, J., Wilmanns, M. & Yuan, J.
J Am Chem Soc. 2009 Apr 15;131(14):5134-44. PubMed
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
Neufeld, C., Filipp, F.V., Simon, B., Neuhaus, A., Schuller, N., David, C., Kooshapur, H., Madl, T., Erdmann, R., Schliebs, W., Wilmanns, M. & Sattler, M.
EMBO J. 2009 Mar 18;28(6):745-54. Epub 2009 Feb 5. PubMed
Mechanical network in titin immunoglobulin from force distribution analysis.
Stacklies, W., Vega, M.C., Wilmanns, M. & Grater, F.
PLoS Comput Biol. 2009 Mar;5(3):e1000306. Epub 2009 Mar 13. PubMed
Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis.
Ruggiero, A., Tizzano, B., Pedone, E., Pedone, C., Wilmanns, M. & Berisio, R.
J Mol Biol. 2009 Jan 9;385(1):153-62. Epub 2008 Oct 22. PubMed
Terminal assembly of sarcomeric filaments by intermolecular beta-sheet formation.
Pinotsis, N., Abrusci, P., Djinovic-Carugo, K. & Wilmanns, M.
Trends Biochem Sci. 2009 Jan;34(1):33-9. Epub 2008 Nov 6. PubMed
Protein assemblies with palindromic structure motifs.
Pinotsis, N. & Wilmanns, M.
Cell Mol Life Sci. 2008 Oct;65(19):2953-6. PubMed
Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization.
Lamber, E.P., Vanhille, L., Textor, L.C., Kachalova, G.S., Sieweke, M.H. & Wilmanns, M.
EMBO J. 2008 Jul 23;27(14):2006-17. Epub 2008 Jun 19. PubMed
Bimolecular fluorescence complementation in structural biology.
Song, Y.H. & Wilmanns, M.
Methods. 2008 Jul;45(3):219-22. Epub 2008 Jul 9. PubMed
Probing lipid- and drug-binding domains with fluorescent dyes.
Black, S.L., Stanley, W.A., Filipp, F.V., Bhairo, M., Verma, A., Wichmann, O., Sattler, M., Wilmanns, M. & Schultz, C.
Bioorg Med Chem. 2008 Feb 1;16(3):1162-73. Epub 2007 Nov 19. PubMed
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin.
Pinotsis, N., Lange, S., Perriard, J.C., Svergun, D.I. & Wilmanns, M.
EMBO J. 2008 Jan 9;27(1):253-64. Epub 2007 Dec 6. PubMed
Low resolution structural models of the basic helix-loop-helix leucine zipper domain of upstream stimulatory factor 1 and its complexes with DNA from small angle X-ray scattering data.
Lamber, E.P., Wilmanns, M. & Svergun, D.I.
Biophys J. 2008 Jan 1;94(1):193-7. Epub 2007 Sep 7. PubMed
High-resolution Structural Analysis of Mammalian Profilin 2a Complex Formation with Two Physiological Ligands: The Formin Homology 1 Domain of mDia1 and the Proline-rich Domain of VASP.
Kursula, P., Kursula, I., Massimi, M., Song, Y.H., Downer, J., Stanley, W.A., Witke, W. & Wilmanns, M.
J Mol Biol. 2007 Oct 24;. PubMed
Protein translocation into peroxisomes by ring-shaped import receptors.
Stanley, W.A., Fodor, K., Marti-Renom, M.A., Schliebs, W. & Wilmanns, M.
FEBS Lett. 2007 Oct 16;581(25):4795-802. Epub 2007 Sep 11. PubMed
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis.
Ruggiero, A., Tizzano, B., Geerlof, A., Pedone, E., Pedone, C., Wilmanns, M. & Berisio, R.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt10):870-3. Epub 2007 Sep 19. PubMed
Second SH3 Domain of Ponsin Solved from Powder Diffraction.
Margiolaki, I., Wright, J.P., Wilmanns, M., Fitch, A.N. & Pinotsis, N.
J Am Chem Soc. 2007 Sep 5;. PubMed
Expression, purification, crystallization and preliminary crystallographic analysis of the mouse transcription factor MafB in complex with its DNA-recognition motif Cmare.
Textor, L.C., Wilmanns, M. & Holton, S.J.
Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt8):657-61. Epub 2007 Jul 7. PubMed
Structure-based approaches to drug discovery against tuberculosis.
Holton, S.J., Weiss, M.S., Tucker, P.A. & Wilmanns, M.
Curr Protein Pept Sci. 2007 Aug;8(4):365-75. PubMed
Paxillin and ponsin interact in nascent costameres of muscle cells.
Gehmlich, K., Pinotsis, N., Hayess, K., van der Ven, P.F., Milting, H., El Banayosy, A., Korfer, R., Wilmanns, M., Ehler, E. & Furst, D.O.
J Mol Biol. 2007 Jun 8;369(3):665-82. Epub 2007 Mar 24. PubMed
Understanding a mechanism of organic cosolvent inactivation in heme monooxygenase P450 BM-3.
Kuper, J., Wong, T.S., Roccatano, D., Wilmanns, M. & Schwaneberg, U.
J Am Chem Soc. 2007 May 9;129(18):5786-7. Epub 2007 Apr 13. PubMed
Rigid Conformation of an Immunoglobulin Domain Tandem Repeat in the A-band of the Elastic Muscle Protein Titin.
Muller, S., Lange, S., Gautel, M. & Wilmanns, M.
J Mol Biol. 2007 May 25;. PubMed
Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay.
Stanley, W.A., Versluis, K., Schultz, C., Heck, A.J. & Wilmanns, M.
Arch Biochem Biophys. 2007 May 1;461(1):50-8. Epub 2007 Mar 15. PubMed
Octameric alcohol oxidase dissociates into stable, soluble monomers upon incubation with dimethylsulfoxide.
Visser, N.V., Wang, D., Stanley, W.A., Groves, M.R., Wilmanns, M., Veenhuis, M. & van der Klei, I.J.
Arch Biochem Biophys. 2007 Mar 15;459(2):208-13. Epub 2007 Jan 23. PubMed
On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths.
Mueller-Dieckmann, C., Panjikar, S., Schmidt, A., Mueller, S., Kuper, J., Geerlof, A., Wilmanns, M., Singh, R.K., Tucker, P.A. & Weiss, M.S.
Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):366-80. Epub 2007Feb 21. PubMed
A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding.
Stanley, W.A., Pursiainen, N.V., Garman, E.F., Juffer, A.H., Wilmanns, M. & Kursula, P.
BMC Struct Biol. 2007 Apr 11;7:24. PubMed
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p.
Stanley, W.A., Filipp, F.V., Kursula, P., Schuller, N., Erdmann, R., Schliebs, W., Sattler, M. & Wilmanns, M.
Mol Cell. 2006 Dec 8;24(5):653-63. PubMed
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis.
Holton, S.J., King-Scott, S., Nasser Eddine, A., Kaufmann, S.H. & Wilmanns, M.
FEBS Lett. 2006 Dec 22;580(30):6898-902. Epub 2006 Nov 30. PubMed
Dynamic architecture of the peroxisomal import receptor Pex5p.
A Stanley, W. & Wilmanns, M.
Biochim Biophys Acta. 2006 Dec;1763(12):1592-8. Epub 2006 Nov 10. PubMed
Cellular target genes of Epstein-Barr virus nuclear antigen 2.
Maier, S., Staffler, G., Hartmann, A., Hock, J., Henning, K., Grabusic, K., Mailhammer, R., Hoffmann, R., Wilmanns, M., Lang, R., Mages, J. & Kempkes, B.
J Virol. 2006 Oct;80(19):9761-71. PubMed
The impact of protein characterization in structural proteomics.
Geerlof, A., Brown, J., Coutard, B., Egloff, M.P., Enguita, F.J., Fogg, M.J., Gilbert, R.J., Groves, M.R., Haouz, A., Nettleship, J.E., Nordlund, P., Owens, R.J., Ruff, M., Sainsbury, S., Svergun, D.I. & Wilmanns, M.
Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1125-36. Epub 2006Sep 19. PubMed
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE.
Alzari, P.M., Berglund, H., Berrow, N.S., Blagova, E., Busso, D., Cambillau, C., Campanacci, V., Christodoulou, E., Eiler, S., Fogg, M.J., Folkers, G., Geerlof, A., Hart, D., Haouz, A., Herman, M.D., Macieira, S., Nordlund, P., Perrakis, A., Quevillon-Cheruel, S., Tarandeau, F., van Tilbeurgh, H., Unger, T., Luna-Vargas, M.P., Velarde, M., Wilmanns, M. & Owens, R.J.
Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1103-13. Epub 2006Sep 19. PubMed
Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus.
Pinotsis, N., Petoukhov, M., Lange, S., Svergun, D., Zou, P., Gautel, M. & Wilmanns, M.
J Struct Biol. 2006 Aug;155(2):239-50. Epub 2006 Apr 27. PubMed
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase.
Ma, Q., Zhao, X., Eddine, A.N., Geerlof, A., Li, X., Cronan, J.E., Kaufmann, S.H. & Wilmanns, M.
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8662-7. Epub 2006 May 30. PubMed
The structure of the 2[4Fe-4S] ferredoxin from Pseudomonas aeruginosa at 1.32-A resolution: comparison with other high-resolution structures of ferredoxins and contributing structural features to reduction potential values.
Giastas, P., Pinotsis, N., Efthymiou, G., Wilmanns, M., Kyritsis, P., Moulis, J.M. & Mavridis, I.M.
J Biol Inorg Chem. 2006 Jun;11(4):445-58. Epub 2006 Apr 5. PubMed
Mechanical strength of the titin Z1Z2-telethonin complex.
Lee, E.H., Gao, M., Pinotsis, N., Wilmanns, M. & Schulten, K.
Structure. 2006 Mar;14(3):497-509. PubMed
Crystal structure of the PB1 domain of NBR1.
Muller, S., Kursula, I., Zou, P. & Wilmanns, M.
FEBS Lett. 2006 Jan 9;580(1):341-4. Epub 2005 Dec 19. PubMed
Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk.
Zou, P., Pinotsis, N., Lange, S., Song, Y.H., Popov, A., Mavridis, I., Mayans, O.M., Gautel, M. & Wilmanns, M.
Nature. 2006 Jan 12;439(7073):229-33. PubMed
Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences.
Kim, C., Gajendran, N., Mittrucker, H.W., Weiwad, M., Song, Y.H., Hurwitz, R., Wilmanns, M., Fischer, G. & Kaufmann, S.H.
Proc Natl Acad Sci U S A 2005 Mar 29;102(13):4830-5. Epub 2005 Mar 16. PubMed
Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit.
Vega, M.C., Zou, P., Fernandez, F.J., Murphy, G.E., Sterner, R., Popov, A. & Wilmanns, M.
Mol Microbiol 2005 Feb;55(3):675-86. PubMed
Two-fold repeated (betaalpha)(4) half-barrels may provide a molecular tool for dual substrate specificity.
Kuper, J., Doenges, C. & Wilmanns, M.
EMBO Rep 2005 Feb;6(2):134-9. PubMed
Molecular crystallography.
Wilmanns, M. & Weiss, M.S. (2005).
In "Encyclopedia of Condensed Matter Physics", Bassani, G., Liedl, G. & Wyder, P. (eds.), pp.453-458, Academic Press
Structural basis of the ATP phosphoribosyltransferase (HisG)2-(HisZ)4-(HisG)2 hetero-oligomeric complex from Thermotoga maritima.
Vega, M.C., Fernandez, F.J., Murphy, G., Zou, P., Popov, A. & Wilmanns, M.
Mol. Microbiol. 2005 (55) 675-686
Synergistic use of synchrotron radiation techniques for biological samples in solution: a case study on protein-ligand recognition by the peroxisomal import receptor Pex5p.
Stanley, W.A., Sokolova, A., Brown, A., Clarke, D.T., Wilmanns, M. & Svergun, D.I.
J Synchrotron Radiat 2004 Nov 1;11(Pt 6):490-6. Epub 2004 Oct 22. PubMed
Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase.
Barabas, O., Pongracz, V., Kovari, J., Wilmanns, M. & Vertessy, B.G.
J Biol Chem 2004 Oct 8;279(41):42907-15. Epub 2004 Jun 17. PubMed
Combinatorial control of gene expression.
Remenyi, A., Scholer, H.R. & Wilmanns, M.
Nat Struct Mol Biol 2004 Sep;11(9):812-5. PubMed
Structural studies of the catalytic reaction pathway of a hyperthermophilic histidinol-phosphate aminotransferase.
Fernandez, F.J., Vega, M.C., Lehmann, F., Sandmeier, E., Gehring, H., Christen, P. & Wilmanns, M.
J Biol Chem 2004 Mar 8;. PubMed
Solvation in protein folding analysis: combination of theoretical and experimental approaches.
Fernandez-Escamilla, A.M., Cheung, M.S., Vega, M.C., Wilmanns, M., Onuchic, J.N. & Serrano, L.
Proc Natl Acad Sci U S A 2004 Mar 2;101(9):2834-9. Epub 2004 Feb 20. PubMed
Adaptation of Class-13 alpha-Amylases to Diverse Living Conditions.
Linden, A. & Wilmanns, M.
Chembiochem 2004 Feb 6;5(2):231-9. PubMed
Structure of the bisubstrate isomerase priA: a smart solution to exploit ancestral half-barrels for dual substrate specifity?
Kuper, J., Doenges, C. & Wilmanns, M.
EMBO Reports 2004 134-139
Evolutionary markers in the (beta/alpha)(8)-barrel fold.
Vega, M.C., Lorentzen, E., Linden, A. & Wilmanns, M.
Curr Opin Chem Biol 2003 Dec;7(6):694-701. PubMed
Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers.
Remenyi, A., Lins, K., Nissen, L.J., Reinbold, R., Scholer, H.R. & Wilmanns, M.
Genes Dev 2003 Aug 15;17(16):2048-59. PubMed
OBF1 enhances transcriptional potential of Oct1.
Lins, K., Remenyi, A., Tomilin, A., Massa, S., Wilmanns, M., Matthias, P. & Scholer, H.R.
EMBO J 2003 May 1;22(9):2188-98. PubMed
Differential Regulation of a Hyperthermophilic alpha -Amylase with a Novel (Ca,Zn) Two-metal Center by Zinc.
Linden, A., Mayans, O., Meyer-Klaucke, W., Antranikian, G. & Wilmanns, M.
J Biol Chem 2003 Mar 14;278(11):9875-84. PubMed
Solution scattering suggests cross-linking function of telethonin in the complex with titin.
Zou, P., Gautel, M., Geerlof, A., Wilmanns, M., Koch, M.H. & Svergun, D.I.
J Biol Chem 2003 Jan 24;278(4):2636-44. PubMed
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.
Terwilliger, T.C., Park, M.S., Waldo, G.S., Berendzen, J., Hung, L.W., Kim, C.Y., Smith, C.V., Sacchettini, J.C., Bellinzoni, M., Bossi, R., De Rossi, E., Mattevi, A., Milano, A., Riccardi, G., Rizzi, M., Roberts, M.M., Coker, A.R., Fossati, G., Mascagni, P., Coates, A.R., Wood, S.P., Goulding, C.W., Apostol, M.I., Anderson, D.H., Gill, H.S., Eisenberg, D.S., Taneja, B., Mande, S., Pohl, E., Lamzin, V., Tucker, P., Wilmanns, M., Colovos, C., Meyer-Klaucke, W., Munro, A.W., McLean, K.J., Marshall, K.R., Leys, D., Yang, J.K., Yoon, H.J., Lee, B.I., Lee, M.G., Kwak, J.E., Han, B.W., Lee, J.Y., Baek, S.H., Suh, S.W., Komen, M.M., Arcus, V.L., Baker, E.N., Lott, J.S., Jacobs W, J.r, Alber, T. & Rupp, B.
Tuberculosis (Edinb) 2003;83(4):223-49. PubMed
Steered molecular dynamics studies of titin i1 domain unfolding.
Gao, M., Wilmanns, M. & Schulten, K.
Biophys J 2002 Dec;83(6):3435-45. PubMed
Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin.
Paavilainen, V.O., Merckel, M.C., Falck, S., Ojala, P.J., Pohl, E., Wilmanns, M. & Lappalainen, P.
J Biol Chem 2002 Nov 8;277(45):43089-95. PubMed
Differential activity by DNA-induced quarternary structures of POU transcription factors.
Remenyi, A., Tomilin, A., Scholer, H.R. & Wilmanns, M.
Biochem Pharmacol 2002 Sep;64(5-6):979-84. PubMed
Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry.
Mayans, O., Ivens, A., Nissen, L.J., Kirschner, K. & Wilmanns, M.
EMBO J 2002 Jul 1;21(13):3245-54. PubMed
The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax.
Pohl, E., Brunner, N., Wilmanns, M. & Hensel, R.
J Biol Chem 2002 May 31;277(22):19938-45. PubMed
Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis.
Fazi, B., Cope, M.J., Douangamath, A., Ferracuti, S., Schirwitz, K., Zucconi, A., Drubin, D.G., Wilmanns, M., Cesareni, G. & Castagnoli, L.
J Biol Chem 2002 Feb 15;277(7):5290-8. PubMed
Stabilization of a ([beta][alpha])8-barrel protein by an engineered disulfide bridge.
Ivens, A., Mayans, O., Szadkowski, H., Jurgens, C., Wilmanns, M. & Kirschner, K.
Eur J Biochem 2002 Feb;269(4):1145-1153. PubMed
Structural Genomics in Europe and Beyond - Shifting Scientific Directions at EMBL Hamburg
Wilmanns, M.
Acta Physica Polonica A, 101, 635-646
Integrated Structural Genomics in Europe
Wilmanns, M.
Gene Funct. Dis. 3, 18-24
Crystallization of redox-insensitive Oct1 POU domain with different DNA-response elements.
Remenyi, A., Pohl, E., Scholer, H.R. & Wilmanns, M.
Acta Crystallogr D Biol Crystallogr 2001 Nov;57(Pt 11):1634-8. PubMed
Matti Saraste (1949-2001).
Wilmanns, M.
Structure (Camb) 2001 Sep;9(9):769-70. PubMed
Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping.
Remenyi, A., Tomilin, A., Pohl, E., Lins, K., Philippsen, A., Reinbold, R., Scholer, H.R. & Wilmanns, M.
Mol Cell 2001 Sep;8(3):569-80. PubMed
Divergent evolution of (betaalpha)8-barrel enzymes.
Henn-Sax, M., Hocker, B., Wilmanns, M. & Sterner, R.
Biol Chem 2001 Sep;382(9):1315-20. PubMed
Stability, catalytic versatility and evolution of the (beta alpha)(8)-barrel fold.
Hocker, B., Jurgens, C., Wilmanns, M. & Sterner, R.
Curr Opin Biotechnol 2001 Aug;12(4):376-81. PubMed
Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin.
Mayans, O., Wuerges, J., Canela, S., Gautel, M. & Wilmanns, M.
Structure (Camb) 2001 Apr 4;9(4):331-40. PubMed
Purification, characterization and crystallization of thermostable anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
Ivens, A., Mayans, O., Szadkowski, H., Wilmanns, M. & Kirschner, K.
Eur J Biochem 2001 Apr;268(8):2246-52. PubMed
Atomic resolution structure of a mutant of the spectrin SH3 domain.
Berisio, R., Viguera, A., Serrano, L. & Wilmanns, M.
Acta Crystallogr D Biol Crystallogr 2001 Feb;57(Pt 2):337-40. PubMed
Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.
Tomilin, A., Remenyi, A., Lins, K., Bak, H., Leidel, S., Vriend, G., Wilmanns, M. & Scholer, H.R.
Cell 2000 Dec 8;103(6):853-64. PubMed
Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion.
Lang, D., Thoma, R., Henn-Sax, M., Sterner, R. & Wilmanns, M.
Science 2000 Sep 1;289(5484):1546-50. PubMed
Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways.
Jurgens, C., Strom, A., Wegener, D., Hettwer, S., Wilmanns, M. & Sterner, R.
Proc Natl Acad Sci U S A 2000 Aug 29;97(18):9925-30. PubMed
Activation of calcium/calmodulin regulated kinases.
Wilmanns, M., Gautel, M. & Mayans, O.
Cell Mol Biol (Noisy-le-grand) 2000 Jul;46(5):883-94. PubMed
Future structural biology applications with a free-electron laser - more than wild dreams?
Wilmanns, M.
J Synchrotron Radiat. 2000 Jan;7(Pt 1):41-6. Epub 2000 Jan 1. PubMed
Crystallization and preliminary X-ray diffraction analysis of the NAD- dependent non--phosphorylating GAPDH of the hyperthermophilic archaeon thermoproteus tenax.
Brunner, N.A., Lang, D.A., Wilmanns, M. & Hensel, R.
Acta Crystallogr D Biol Crystallogr 2000 Jan;56 (Pt 1):89-91 PubMed
Activation of calcium/calmodulin regulated kinases.
Wilmanns, M., Gautel, M. & Mayans, O.
Cell. Mol. Biol. (Noisy-le-Grand) 2000 46 883-894
The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications.
Knochel, T., Ivens, A., Hester, G., Gonzalez, A., Bauerle, R., Wilmanns, M., Kirschner, K. & Jansonius, J.N.
Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9479-84 PubMed
Efficient expression, purification and crystallisation of two hyperthermostable enzymes of histidine biosynthesis.
Thoma, R., Obmolova, G., Lang, D.A., Schwander, M., Jeno, P., Sterner, R. & Wilmanns, M.
FEBS Lett 1999 Jul 2;454(1-2):1-6 PubMed
Thermodynamic analysis of alpha-spectrin SH3 and two of its circular permutants with different loop lengths: discerning the reasons for rapid folding in proteins.
Martinez, J.C., Viguera, A.R., Berisio, R., Wilmanns, M., Mateo, P.L., Filimonov, V.V. & Serrano, L.
Biochemistry 1999 Jan 12;38(2):549-59 PubMed
Regulation von Proteinkinasen der MLCK-Familie.
Wilmanns, M. & Gautel, M.
Biospektrum 1999 5 198-201
X-ray analysis of protein crystals with thin plate morphology.
Mayans, O. & Wilmanns, M.
J. Synchr. Rad. 1999 6 1016-1020
Structural basis for activation of the titin kinase domain during myofibrillogenesis
Mayans, O., van der Ven, P.F., Wilm, M., Mues, A., Young, P., Furst, D.O., Wilmanns, M. & Gautel, M.
Nature 1998 Oct 29 395(6705) 863-869 PubMed
Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions.
Pisabarro, M.T., Serrano, L. & Wilmanns, M.
J Mol Biol 1998 Aug 21;281(3):513-21. PubMed
Different folding transition states may result in the same native structure.
Viguera, A.R., Serrano, L. & Wilmanns, M.
Nat Struct Biol 1996 Oct;3(10):874-80 PubMed
Structure of the binding site for inositol phosphates in a PH domain.
Hyvonen, M., Macias, M.J., Nilges, M., Oschkinat, H., Saraste, M. & Wilmanns, M.
EMBO J 1995 Oct 2;14(19):4676-85 PubMed
Inverse protein folding by the residue pair preference profile method: estimating the correctness of alignments of structurally compatible sequences.
Wilmanns, M. & Eisenberg, D.
Protein Eng 1995 Jul;8(7):627-39. PubMed
High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Musacchio, A., Saraste, M. & Wilmanns, M.
Nat Struct Biol 1994 Aug;1(8):546-51. PubMed