12:00 - 14:00

Arrival / Registration and Lunch

14:00

Welcome

Victor Lamzin

14:15 - 16:30

Session 1. Catalysis at the Cellular Level

Chair: Stephen Benkovic

14:15 - 14:50

Tomitake Tsukihara - Structure of the Gap Junction Channel and its Implications on its Biological Functions

14:50 - 15:25

Steve Ealick - Structural and Mechanistic Studies on Two Unpredicted Radical SAM Enzymes

15:25 - 16:00

Daniel Amador Naguez - Metabolomic Data Reveals Pathways and Regulatory Principles in C. acetobutylicum

16:00 - 16:20

Poster Talk: Sarah Wilkins - Characterisation of Substrate Specificity of the Oxygen-Dependent Asparaginyl Hydroxylase FIH-1

16:20 - 17:00

Coffee / Posters

17:00 - 18:30

Session 2. New Biocatalysts

Chair: Rik Wierenga

17:00 - 17:35

Chi-Huey Wong - Post-translational Glycosylation: Challenges and Opportunities

17:35 - 18:10

Marco Fraaije - New Mechanistic Insights into Oxidative Flavoenzymes

18:10 - 18:30

Poster talk: Evangelia Kapetaniou - Engineering New Enzymatic Activities into TIM-Barrel Framework

18:30 - 19:30

Poster session

8:30 - 9:00

Morning coffee

9:00 - 11:05

Session 3. Advanced Crystallographic Approaches

Chair: Andrea Schmidt

9:00 - 9:35

John Helliwell - The Determination of Protonation States in Proteins

9:35 - 10:10

Dominique Bourgouis - Combining Spectroscopy and Crystallography: a tool to investigate GFP fluorescence

10:10 - 10:45

Ilme Schlichting - When Flavins get the Blues — On Blue-Light Photoreceptor Signaling

10:45 - 11:05

Poster Talk: Michele Cianci - Crystallographic Analysis of Counter-Ion Effects on Subtilisin Enzymatic Action in Acetonitrile

11:05 - 11:30

Coffee Break

11:30 - 13:00

Session 4. Molecular Medicine

Chair: Reinhard Sterner

11:30 - 12:05

Kathleen Aertgeerts - Structure-Based Drug Design: Increasing the likelihood to create new medicines

12:05 - 12:40

Rebecca Wade

12:40 - 14:30

Lunch / Posters

14:30 - 15:45

Session 5. Spectrometry and Single Molecule Techniques

Chair: Anne-Marie Lambeir

14:30 - 15:05

Henry Chapman - Nanocrystallography with X-ray Free-Electron Lasers

15:05 - 15:40

Ari Gafni - Single Molecule Fluorescence Studies of Amyloid Beta Pore Formation and Cell Toxicity

15:40 - 16:15

Jens Andersen - Modern Mass Spectrometry Approaches for Studying Proteins in vivo and in vitro

16:15 - 16:35

Poster Talk: Georg Willie - Looking at Enzymes in the Infrared

16:35 - 17:00

Coffee

17:00 - 19:00

Session 6. Data Mining

Chair: Victor Lamzin

17:00 - 17:35

Janet Thornton -The Evolution of Enzyme Mechanisms and Functional Diversity

17:35 - 18:10

Dietmar Schomburg - From Metabolism to Systems Biology

18:10 - 18:45

Richard Morris - Structural Bioinformatics and Catalysis

18:45 - 19:45

Poster Session

20:00

Conference Dinner

9:30 - 10:00

Morning coffee

10:00 - 12:40

Session 7. Biocomputing Approaches

Chair: Richard Morris

10:00 - 10:35

Michael Sutcliffe - Dynamically-Coupled Enzyme Catalysis: Insight from Simulation

10:35 - 11:10

Stephen Benkovic - The Importance of the Intrinsic Dynamic Properties of Enzymes

11:10 - 11:45

Gerrit Groenhof - Computer Simulations of Photobiological Processes: the Effect of the Protein Environment

11:45 - 12:05

Poster Talk: Julia Fischer - The Structures and Physicochemical Properties of Cofactors in Biocatalysis

12:05 - 12:25

Poster Talk: Ramon Crehuet - Can we Include Protein Flexibility when Computing Reaction Mechanisms?

12:25 - 14:00

Lunch

14:00 - 16:00

Session 8. Enzyme Reaction Mechanisms

Chair: Andrea Mattevi

14:00 - 14:35

Perry Frey - Strong hydrogen bonding in enzymatic catalysis: The case for an LBHB in reactions of serine proteases

14:35 - 15:10

John Gerlt - Discovery and Prediction of Functions in the Enolase Superfamily

15:10 - 15:45

Dale Poulter - The Mechanism for Double Bond Isomerization in the Isoprenoid Biosynthetic Pathway

15:45 - 16:05

Poster Talk: Judit Toth: Pi-pi interaction between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase

16:05 - 16:30

Discussion / Closing Remarks

Victor Lamzin & Andrea Mattevi