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| Dino Moras - | |
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Nuclear receptors are ligand dependent transcription regulators that
function either as homodimers or as heterodimers with RXR/USP. A
structure-based sequence analysis aimed at discovering the molecular
mechanism that controls the dimeric association of the ligand-binding
domain reveals two sets of differentially conserved residues which
partition the entire NR superfamily into two classes related to their
oligomeric behaviour. The nature of the interaction between the
ligands and these motifs and their role in the transactivation
process is now investigated. The structural genomic approach allows
to address these questions in an efficient way. [ref: Brelivet Y.
et al, EMBO reports (2004) 5:423-29]
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