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| Rob Russell - | |
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Protein interactions are central to most biological processes,
and are currently the subject of great interest. Yet despite the many
recently developed methods to identify protein interactions, little
attention has been paid to one of the best sources of data: complexes of
known three-dimensional (3D) structure. In this talk I will discuss how
such complexes can be used to study and predict protein interactions &
complexes, and to interrogate interaction networks proposed by methods
such as two-hybrid screens or affinity purifications. I will also discuss
how EM data can be combined with bioinformatics & modelling to predict
structures for complexes or for parts of interaction networks.
RELATED PUBLICATIONS
| 1. |
P. Aloy, B.Bottcher, H. Ceulemans, C. Leutwein, C. Mellwig, S. Fischer,
A.C. Gavin, P. Bork, G. Superti-Furga, L. Serrano, R.B. Russell,
Structure-based assembly of protein complexes in yeast, Science, 303,
2026-2029, 2004. |
| 2. |
P. Aloy, H. Ceulemans, A. Stark, R.B. Russell, The relationship between
sequence and inteaction divergence in proteins. J. Mol. Biol., 332,
989-998, 2003. |
| 3. |
P. Aloy, F.D. Ciccarelli, C. Leutwein, A.C. Gavin, G. Superti-Furga, P.
Bork, B. Boettcher, R.B. Russell A complex prediction:
three-dimensional model of the yeast exosome. EMBO reports, 3, 628-635,
2002. |
| 4. |
P. Aloy, R.B. Russell, InterPreTS: Protein interaction prediction
through tertiary structure. Bioinformatics, 19, 161-162, 2003. |
| 5. |
P. Aloy, R.B. Russell, The third dimension for protein interactions and
complexes. Trends Biochem. Sci., 27, 633-638, 2002. |
| 6. |
P. Aloy, R.B. Russell Interrogating protein interaction networks
through structural biology. Proc. Natl. Acad. Sci. USA, 99, 5896-5901,
2002. |
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