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   16 September
 
   15 September
 
   PDB Exhibition
 
Structural Biology at Crossroads:
Wednesday, 15th September
  14.00 - 14.10  
  Matthias Wilmanns - Introduction  
  14.10 - 14.20  
  Albrecht Wagner - Welcome  
  14.20 - 14.50  
  Fotis C. Kafatos - Present and Future Perspectives of the European Molecular Biology Laboratory.  
  14.50 - 15.20  
  Keith Wilson - Protein cystallography at EMBL Hamburg 1985-1995 plus some recent advances in phasing  
  15.20 - 15.50  
  Dino Moras - Structural genomics approach for the analysis of protein function at atomic level: The case of nuclear receptors of hormones  
  15.50 - 16.10    Coffee break  
  

Session 1 (ESBF microsymposium):

Frontiers and challenges in structural biology
(Chairs: Martino Bolognesi, Manfred Weiss)
  16.10 - 16.40  
  David Eisenberg - Towards the Structural Genomics of Protein Complexes  
  16.40 - 17.05  
  Peer Bork - Function prediction in 4D  
  17.05 - 17.30  
  So Iwata - Structure and function of membrane transporters  
  17.30 - 17.55  
  Daniela Stock - The rotary motors in F- and V-type ATPases  
  18.00 - 20.00    Dinner at the DESY BISTRO  
  

Evening session

30 Years of EMBL-Hamburg (1974-2004)
  20.00 - 20.25  
  Ken Holmes - The molecular basis of muscle contraction  
  20.25 - 20.50  
  Gerd Rosenbaum - The EMBL-Outstation at DESY: From Conception to Early Childhood  
  20.50 - 21.15  
  Heinrich Stuhrmann - Thanks to PIA  
  21.15 - 21.40  
  Zbyszek Dauter - Making use of the weak phasing signals  
 
Thursday, 16th September
  

Session 1, continued
  09.00 - 09.30  
  Wolfgang Baumeister - Exploring the inner space of cells by cryoelectron-tomography  
  09.30 - 09.55  
  Neil Isaacs - Structural studies on components of the bacterial photosynthetic unit  
  09.55 - 10.20  
  Stephen Cusack - Towards a complete atomic model of the adenovirus capsid  
  10.20 - 10.35  
  Kristina Djinovic-Carugo - X-rays make the enzymes go around  
  10.35 - 11.00    Coffee break  
  11.00 - 11.25  
  Patrick Cramer - Multiprotein transcription complexes  
  11.25 - 11.50  
  Elena Conti - Molecular mechanisms in eukaryotic mRNA surveillance  
  11.50 - 12.05  
  Pinak Chakrabarti - Structure of CII, a transcriptional activator of bacteriophage lambda, with a novel quaternary association  
  12.05 - 12.20  
  Olga Mayans - Assessing flexibility in the elastic, multi-domain, muscle filament titin  
  12.20 - 12.40  
  Josefina Enfedaque - Structural Genomics in FP6 and beyond: the EU support.  
  12.40 - 15.00    Poster presentation and LUNCH  
  

Session 2 (BIOXHIT microsymposium):

Present and future sources and instruments
(Chairs: Victor Lamzin, Edgar Weckert)
  15.30 - 16.00  
  Jochen Schneider - The future of photon sciences at DESY  
  16.00 - 16.25  
  Soichi Wakatsuki - Protein transport and glycosylation: towards the limits of synchrotron protein crystallography  
  16.25 - 16.50  
  Gerd Rosenbaum - PX Beamlines for Demanding Projects and High Throughput at the APS  
  16.50 - 17.15    Coffee break  
  17.15 - 17.40  
  Elizabeth Duke - Diamond and the Life Sciences - Present Plans and Future Prospects  
  17.40 - 18.05  
  Andrew Thompson - Structural Biology Facilities at SOLEIL  
  18.05 - 18.30  
  Janos Hadju - Structural biology beyond the conventional damage limits  
  18.30 - 18.45  
  Dieter Einfeld - A Concept for the Spanish Light Source ALBA  
  18.45 - 19.00  
  Stephen Cusack - Integrating Structural Biology in Grenoble.  
  

Evening session
  19.15 - 22.00  
  Helen Berman - PDB Exhibit 'The Art of Science' and Dinner  
 
Friday, 17th September
  

Session 3 (SPINE microsymposium):

Structural proteomics in the post-genomic era: the need for interdisciplinarity
(Chairs: Joel Sussman, Stephen Cusack)
  09.00 - 09.30  
  Anna Tramontano - Progress and perspectives in protein structure prediction  
  09.30 - 09.55  
  Rob Russell - A structural perspective on protein interactions and complexes  
  09.55 - 10.20  
  Gianni Cesareni - Selectivity and promiscuity in interaction networks mediated by peptide recognition modules  
  10.20 - 10.45  
  James Penner Hahn - Biological X-ray Spectroscopy at a Third Generation Synchrotron Source  
  10.45 - 11.15    Coffee break  
  11.15 - 12.30  
  Tour to PETRA-III and XFEL facilities  
  12.30 - 15.00  
  Poster Presentation and Lunch  
  15.30 - 16.00  
  David Stuart - HTP technologies - any impact on cutting edge structural biology?  
  16.00 - 16.25  
  Christian Cambillau - Structural Genomics of Viral Proteins: the SARS Case  
  16.25 - 16.40  
  William Shepard - Mycobacterial Structural Genomics at the Pasteur Institute: Status report  
  16.40 - 16.55  
  Rajan Sankaranarayanan - A novel tunnel in mycobacterial PKS18 reveals structural basis for generating diverse metabolites  
  16.55 - 17.15    Coffee break  
  

Session 4:

The use of biological structures in present and novel, emerging biological disciplines, including drug discovery
(Chairs: Matthias Wilmanns, Andrea Schmidt)
  17.15 - 17.45  
  Joel Sussman - Structure/Function Studies on Cholinesterase-Like Adhesion Molecules  
  17.45 - 18.10  
  Andrea Musacchio - Activation of Mad2 in the spindle checkpoint resembles the template-assisted conversion of prions  
  18.10 - 18.25  
  Orsolya Barabas - Structural biology of dUTPase enzyme family: understanding the tools for uracil-DNA metabolism  
  18.25 - 18.40  
  Will Stanley - Receptor Recognition by the Flexible Peroxisomal Targeting Signal Type 1 of Sterol Carrier Protein 2  
  18.40 - 18.55  
  Mariusz Jaskolski - 3D Domain swapping in cystatin C - implications for amyloidogenesis  
  19.00    Boat trip on the river Elbe  
 
Saturday, 18th September
  09.00 - 09.30  
  Sir Tom Blundell - The structural biology of multiprotein systems: challenges for drug discovery  
  09.30 - 09.55  
  Markus Grütter - Structural Biology of Apoptotic and Inflammatory Pathways  
  09.55 - 10.10  
  Michael Hennig - X-ray structure based design for lead generation and optimization  
  10.10 - 10.25  
  Aengus MacSweeney - Dual action NEP-DPPIV inhibitors as a concept for the treatment of type II diabetes  
  10.25 - 10.50    Coffee break  
  10.50 - 11.15  
  Dmitri Svergun - Small-angle x-ray scattering from solutions of biological macromolecules  
  11.15 - 11.30  
  Michal Hammel - Structural Insights into the Mechanism of Formation of Cellulosomes probed by SAXS  
  11.30 - 11.55  
  Martino Bolognesi - Two cellular functions in the brefeldin-A ADP-ribosylation substrate protein BARS  
  Closing lecture :
  11.55 - 12.25  
  Ada Yonath - The Amazing Ribosomal Architecture: From Positional Catalysis to Antibiotics Synergism  
  12.25 - 12.40  
  Presentation of poster awards