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| Olwyn Byron - Use of Small Angle Scattering with Biophysical Methods | |
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Olwyn Byron
Glasgow University, UK
In this session I will describe in detail the principles underlying analytical ultracentrifugation and its utility in characterising biomacromolecular systems that are also being studied with small-angle scattering. This will be illustrated with a number of examples chosen from the literature in which additional complementary biophysical methods are used (e.g. circular dichroism, NMR, hydrodynamic bead modelling and bioinformatics-based modelling).
Dempsey, B. R., A. Economou, S. D. Dunn, and B. H. Shilton. (2002) The ATPase domain of SecA can form a tetramer in solution. J. Mol. Biol. 315, 831-843.
Solovyova, A. S., M. Nollmann, T. J. Mitchell, and O. Byron. (2004) The solution structure and oligomerisation behaviour of two bacterial toxins: pneumolysin and perfringolysin O. Biophys. J. 87, 540-552.
Nollmann, M., J. He, O. Byron, and W. Stark. (2004) Solution structure of the Tn3 resolvase-crossover site synaptic complex. Molec. Cell 16, 127-137.
Mattinen, M.-L., K. Paakkonen, T. Ikonen, J. Craven, T. Drakenberg, R. Serimaa, J. Waltho, and A. Annila. (2002) Quaternary structure built from subunits combining NMR and small-angle x-ray scattering data. Biophys. J. 83, 1177-1183.
Smolle, M., A. E. Prior, A. E. Brown, A. Cooper, O. Byron, and J. G. Lindsay. (2006) A new level of architectural complexity in the human pyruvate dehydrogenase complex. J. Biol. Chem. 281, 19772-19780.
Date/time: Friday, 27 October, 9:00
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