Total number of highlights (IF > 20) referencing P13 and/or P14: 29 [ as of 28/09/2022 ]

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2022


29: Widespread occurrence of covalent lysine-cysteine redox switches in proteins.
Rabe von Pappenheim F, Wensien M, Ye J, Uranga J, Irisarri I, de Vries J, Funk LM, Mata RA, Tittmann K.
Nat Chem Biol. (2022 Feb)UNK:pp. UNK
DOI: 10.1038/s41589-021-00966-5  |   PUBMED: 35165445  |   IF(2020) = 41.8
PDB [P14]:  7ODO  7ODQ  7O9G  7ODP  7OEY   

Number of publications for 2022: 1


2021


28: Profiling cellular diversity in sponges informs animal cell type and nervous system evolution.
Musser JM, Schippers KJ, Nickel M, Mizzon G, Kohn AB, Pape C, Ronchi P, Papadopoulos N, Tarashansky AJ, Hammel JU, Wolf F, Liang C, Hernández-Plaza A, Cantalapiedra CP, Achim K, Schieber NL, Pan L, Ruperti F, Francis WR, Vargas S, Kling S, Renkert M, Polikarpov M, Bourenkov G, Feuda R, Gaspar I, Burkhardt P, Wang B, Bork P, Beck M, Schneider TR, Kreshuk A, Wörheide G, Huerta-Cepas J, Schwab Y, Moroz LL, Arendt D.
Science. 2021 Nov 5;374(6568):717-723.
DOI: 10.1126/science.abj2949.  |   PUBMED: 34735222.  |   IF(2018) = 41.1
PDB [P14]:   

27: Structural basis of cytokine-mediated activation of ALK family receptors.
De Munck S, Provost M, Kurikawa M, Omori I, Mukohyama J, Felix J, Bloch Y, Abdel-Wahab O, Bazan JF, Yoshimi A, Savvides SN.
Nature. (2021 Oct 13). Epub ahead of print
DOI: 10.1038/s41586-021-03959-5  |   PUBMED: 34646012  |   IF(2018) = 43.1
PDB [P13P14]:  7NX4  7NX2  7NX1   

26: A lysine-cysteine redox switch with an NOS bridge regulates enzyme function.
Wensien M, von Pappenheim FR, Funk LM, Kloskowski P, Curth U, Diederichsen U, Uranga J, Ye J, Fang P, Pan KT, Urlaub H, Mata RA, Sautner V, Tittmann K.
Nature. 2021 May;593(7859):460-464. Epub 2021 May 5.
DOI: 10.1038/s41586-021-03513-3  |   PUBMED: 33953398  |   IF(2018) = 43.1
PDB [P14]:  6ZWJ  7BBW  7BBX  6ZWF  6ZX4  6ZWH   

25: X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schluenzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A.
Science. (2021 May 7) 372(6542):642-646
DOI: 10.1126/science.abf7945  |   PUBMED: 33811162  |   IF(2018) = 41.1
PDB [P14]:  7AXO   

24: Structural insights into the inhibition of glycine reuptake.
Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR, Dawson RJP, Nissen P.
Nature (2021 Mar)591:677-681
DOI: 10.1038/s41586-021-03274-z  |   PUBMED: 33658720  |   IF(2018) = 43.1
PDB [P14]:  6ZPL  6ZBV   

Number of publications for 2021: 5


2020


23: Architecture and functional dynamics of the pentafunctional AROM complex.
Arora Veraszto H, Logotheti M, Albrecht R, Leitner A, Zhu H, Hartmann MD,
Nat Chem Biol. 2020 Jul 6.
DOI: 10.1038/s41589-020-0587-9  |   PUBMED: 32632294  |   IF(2020) = 41.8
PDB [P14]:  6HQV   

22: Structural basis for antibiotic action of the B1 antivitamin 2'-methoxy-thiamine.
Rabe von Pappenheim F, Aldeghi M, Shome B, Begley T, de Groot BL, Tittmann K.
Nat Chem Biol. (2020 Aug) UNK:pp. UNK
DOI: 10.1038/s41589-020-0628-4  |   PUBMED: 32839604  |   IF(2020) = 41.8
PDB [P14]:  6TJ8  6TJ9   

21: Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Singh K, Graf B, Linden A, Sautner V, Urlaub H, Tittmann K, Stark H, Chari A
Cell. 2020 Mar 19;180(6):1130-1143.e20.
DOI: 10.1016/j.cell.2020.02.034  |   PUBMED: 32160528  |   IF(2018) = 36.2
PDB [P14]:  6QL9  6QL7   

20: Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture.
Gulen B, Rosselin M, Fauser J, Albers MF, Pett C, Krisp C, Pogenberg V, Schlüter H, Hedberg C, Itzen A.
Nat Chem. (2020 Aug)12:732-739
DOI: 10.1038/s41557-020-0484-6  |   PUBMED: 32632184  |   IF(2019) = 21.7
PDB [P13]:  6SIU   

19: p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Gebel J, Tuppi M, Chaikuad A, Hotte K, Schroder M, Schulz L, Lohr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dotsch V,
Nat Chem Biol. 2020 Jul 27. pii: 10.1038/s41589-020-0600-3. doi:10.1038/s41589-020-0600-3.
DOI: 10.1038/s41589-020-0600-3 [doi]  |   PUBMED: 32719556  |   IF(2020) = 41.8
PDB [P13]:  6RU6   

Number of publications for 2020: 5


2019


18: Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.
Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U
Cell. 2019 Dec 12;179(7):1537-1550.e19.
DOI: 10.1016/j.cell.2019.11.024  |   PUBMED: 31835032  |   IF(2018) = 36.2
PDB [P13]:  6RFG   

17: Liquid application method for time-resolved analyses by serial synchrotron crystallography.
Mehrabi P, Schulz EC, Agthe M, Horrell S, Bourenkov G, von Stetten D, Leimkohl JP, Schikora H, Schneider TR, Pearson AR, Tellkamp F, Miller RJD
Nat Methods. 2019 Oct;16(10):979-982. Epub 2019Sep 16.
DOI: 10.1038/S41592-019-0553-1  |   PUBMED: 31527838  |   IF(2018) = 28.5
PDB [P14]:  6RNC  6RNB  6RND  6RNF  6QNJ  6QNH  6QNI  6QND  6QNB  6QNC   

16: Marine Proteobacteria metabolize glycolate via the beta-hydroxyaspartate cycle.
Schada von Borzyskowski L, Severi F, Kruger K, Hermann L, Gilardet A, Sippel F, Pommerenke B, Claus P, Cortina NS, Glatter T, Zauner S, Zarzycki J, Fuchs BM, Bremer E, Maier UG, Amann RI, Erb TJ,
Nature. 2019 Nov;575(7783):500-504. Epub 2019 Nov13.
DOI: 10.1038/s41586-019-1748-4  |   PUBMED: 31723261  |   IF(2018) = 43.1
PDB [P13]:  6RQA   

15: Low-barrier hydrogen bonds in enzyme cooperativity.
Dai S, Funk LM, von Pappenheim FR, Sautner V, Paulikat M, Schroder B, Uranga J, Mata RA, Tittmann K,
Nature. 2019 Sep 18.
DOI: 10.1038/s41586-019-1581-9  |   PUBMED: 31534226  |   IF(2018) = 43.1
PDB [P13P14]:  6HAD  6HA3  6RJB  6RJC  6HAF   

14: Time-resolved crystallography reveals allosteric communication aligned withmolecular breathing.
Mehrabi P, Schulz EC, Dsouza R, Muller-Werkmeister HM, Tellkamp F, Miller RJD, Pai EF,
Science. 2019 Sep 13;365(6458):1167-1170.
DOI: 10.1126/SCIENCE.AAW9904  |   PUBMED: 31515393  |   IF(2018) = 41.1
PDB [P14]:  6QI1  6QHY  6QHX   

13: Protein crystallization promotes type 2 immunity and is reversible by antibodytreatment.
Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Goncalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN,
Science. 2019 May 24;364(6442).
DOI: 10.1126/SCIENCE.AAW4295  |   PUBMED: 31123109  |   IF(2018) = 41.1
PDB [P14]:  6QRN  6GKS  6GKQ   

12: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebscycle.
Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K,
Nature. 2019 Apr 3.
DOI: 10.1038/S41586-019-1095-5  |   PUBMED: 30944476  |   IF(2018) = 43.1
PDB [P13P14]:  6HXK  6QCL  6QFB   

Number of publications for 2019: 7


2018


11: The hit-and-return system enables efficient time-resolved serial synchrotron crystallography.
Schulz EC, Mehrabi P, Muller-Werkmeister HM, Tellkamp F, Jha A, Stuart W, Persch E, De Gasparo R, Diederich F, Pai EF, Miller RJD,
Nat Methods. 2018 Nov;15(11):901-904. Epub 2018Oct 30.
DOI: 10.1038/S41592-018-0180-2  |   PUBMED: 30377366  |   IF(2018) = 28.5
PDB [P14]:  6FSX  6GXH  6GXT   

10: Transposase-DNA Complex Structures Reveal Mechanisms for ConjugativeTransposition of Antibiotic Resistance.
Rubio-Cosials A, Schulz EC, Lambertsen L, Smyshlyaev G, Rojas-Cordova C, Forslund K, Karaca E, Bebel A, Bork P, Barabas O
Cell. 2018 Mar 22;173(1):208-220.e20. Epub 2018 Mar 15.
DOI: 10.1016/J.CELL.2018.02.032  |   PUBMED: 29551265  |   IF(2018) = 36.2
PDB [P13]:  6EN1  6EN2  6EN0  6EMY  6EMZ   

9: Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23Receptor Enables Recruitment of the Shared Receptor IL-12Rbeta1.
Bloch Y, Bouchareychas L, Merceron R, Skladanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN
Immunity. 2018 Jan 16;48(1):45-58.e6. Epub2017 Dec 26.
DOI: 10.1016/J.IMMUNI.2017.12.008  |   PUBMED: 29287995  |   IF(2018) = 21.5
PDB [P14]:  5NJD  5MXA  5MZV  5M85   

Number of publications for 2018: 3


2017


8: Mechanism of Transcription Anti-termination in Human Mitochondria.
Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D,
Cell. 2017 Oct 7.
DOI: 10.1016/J.CELL.2017.09.035  |   PUBMED: 29033127   |   IF(2018) = 36.2
PDB [P13]:  5OL9   

7: Structural Basis for Mitotic Centrosome Assembly in Flies.
Feng Z, Caballe A, Wainman A, Johnson S, Haensele AFM, Cottee MA, Conduit PT, Lea SM, Raff JW,
Cell. 2017 Jun 1;169(6):1078-1089.e13.
DOI: 10.1016/J.CELL.2017.05.030  |   PUBMED: 28575671  |   IF(2018) = 36.2
PDB [P13]:  5MW9  5MW0   

6: Core Mediator structure at 3.4 A extends model of transcription initiationcomplex.
Nozawa K, Schneider TR, Cramer P,
Nature. 2017 May 11;545(7653):248-251.
DOI: 10.1038/NATURE22328  |   PUBMED: 28467824  |   IF(2018) = 43.1
PDB [P14]:  5N9J   

Number of publications for 2017: 3


2016


5: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
Schrader J, Henneberg F, Mata RA, Tittmann K, Schneider TR, Stark H, Bourenkov G, Chari A
Science. 2016 Aug 5;353(6299):594-8.
DOI: 10.1126/SCIENCE.AAF8993  |   PUBMED: 27493187  |   IF(2015) = 34.6
PDB [P14]:  5LE5  5LF1  5LF0  5LF3  5LF4  5LF6  5LF7  5LEX  5LEY  5LEZ   

Number of publications for 2016: 1


2013


4: CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis.
Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T.
Cell. 155:647 (2013).
DOI: 10.1016/j.cell.2013.09.050  |   PUBMED: 24243021  |   IF(2018) = 36.2
PDB [P14]:  4C2G   

3: Crystal structure of the 14-subunit RNA polymerase I
Fernandez-Tornero C, Moreno-Morcillo M, Rashid UJ, Taylor NM, Ruiz FM, Gruene T, Legrand P, Steuerwald U, Mueller CW.
Nature. 502:644 (2013)
DOI: 10.1038/nature12636  |   PUBMED: 24153184  |   IF(2018) = 43.1
PDB [P14]:  4C3I   

2: The hepatitis B virus preS1 domain hijacks host trafficking proteins by motif mimicry.
Jürgens MC, Vürüs J, Rautureau GJ, Shepherd DA, Pye VE, Muldoon J, Johnson CM, Ashcroft AE, Freund SM, Ferguson N.
Nat Chem Biol. 2013 Sep;9(9):540-7.
DOI: 10.1038/nchembio.1294.  |   PUBMED: 23851574  |   IF(2013) = 13.2
PDB [P14]:  3ZHF   

1: Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann C C, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner K P
Nature. 2013 498:332-337
DOI: 10.1038/nature12305  |   PUBMED: 23722159  |   IF(2014) = 41.4
PDB [P14]:  4KB6