Total number of publications referencing P13 (320) and/or P14 (210): 531 [ as of 05/10/2022 ]

2022

531: Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
Weidenhausen J, Kopp J, Ruger-Herreros C, Stein F, Haberkant P, Lapouge K, Sinning I.
Int J Mol Sci (2022 Sep)23:10805
DOI: 10.3390/ijms231810805 | PUBMED: 36142717
PDB [P13]: 7OJU

530: Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.
Hyjek-Składanowska M, Anderson BA, Mykhaylyk V, Orr C, Wagner A, Poznański JT, Skowronek K, Seth P, Nowotny M.
Nucleic Acids Res. (2022 Sep)UNK:gkac774
DOI: 10.1093/nar/gkac774 | PUBMED: 36124719 | IF(2018) = 11.1
PDB [P13]: 7ZVN

529: Deamidation of the human eye lens protein γS-crystallin accelerates oxidative aging.
Norton-Baker B, Mehrabi P, Kwok AO, Roskamp KW, Rocha MA, Sprague-Piercy MA, von Stetten D, Miller RJD, Martin RW.
Structure. (2022 May)30:763-776.e4
DOI: 10.1016/j.str.2022.03.002 | PUBMED: 35338852 | IF(2018) = 4.9
PDB [P13P14]: 7N38 7N39 7N36 7N3A 7N3B 7N37

528: Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C.
Killer M, Finocchio G, Mertens HDT, Svergun DI, Pardon E, Steyaert J, Löw C.
Front Mol Biosci. 2022 Jul 11;9:917725.
DOI: 10.3389/fmolb.2022.917725 | PUBMED: 35898305 | IF(2022) = 4.6
PDB [13P14]:

527: Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.
Müller IK, Winter C, Thomas C, Spaapen RM, Trowitzsch S, Tampé R.
Nat Commun. (2022 Sep)13:5383
DOI: 10.1038/s41467-022-32841-9 | PUBMED: 36104323 | IF(2022) = 14.9
PDB [13]: 7QNG

526: Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.
Gao S, Sylvester K, Song L, Claff T, Jing L, Woodson M, Weiße RH, Cheng Y, Schäkel L, Petry M, Gütschow M, Schiedel AC, Sträter N, Kang D, Xu S, Toth K, Tavis J, Tollefson AE, Müller CE, Liu X, Zhan P.
J Med Chem. (2022 Sep)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.2c01146 | PUBMED: 36107752 | IF(2018) = 6.1
PDB [P13P14]: 8ACD 8ACL

525: Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Zeke A, Takács T, Sok P, Németh K, Kirsch K, Egri P, Póti ÁL, Bento I, Tusnády GE, Reményi A.
Nat Commun. (2022 Sep)13:5439
DOI: 10.1038/s41467-022-32918-5 | PUBMED: 36114179 | IF(2022) = 14.9
PDB [P14]: 7PPL 7PPM 7PPN

524: Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Figiel M, Gapińska M, Czarnocki-Cieciura M, Zajko W, Sroka M, Skowronek K, Nowotny M.
Nucleic Acids Res. (2022 Sep)50:10026-10040
DOI: 10.1093/nar/gkac772 | PUBMED: 36107766 | IF(2018) = 11.1
PDB [P14]: 7R07

523: Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Shvarev D, Schoppe J, König C, Perz A, Füllbrunn N, Kiontke S, Langemeyer L, Januliene D, Schnelle K, Kümmel D, Fröhlich F, Moeller A, Ungermann C.
Elife. (2022 Sep)11:e80901
DOI: 10.7554/elife.80901 | PUBMED: 36098503 | IF(2018) = 7.6
PDB [P13]: 7ZTY

522: A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
Alexa A, Sok P, Gross F, Albert K, Kobori E, Póti ÁL, Gógl G, Bento I, Kuang E, Taylor SS, Zhu F, Ciliberto A, Reményi A.
Nat Commun. 2022 Jan 25;13(1):472.
DOI: 10.1038/s41467-022-28109-x | PUBMED: 35078976 | IF(2022) = 14.9
PDB [P14]: 7OPO 7OPM

521: Crystal structures of free and ligand-bound forms of the TetR/AcrR-like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism.
Werten S, Waack P, Palm GJ, Virolle MJ, Hinrichs W.
FEBS J. (2022 Aug)UNK:pp. UNK
DOI: 10.1111/febs.16606 | PUBMED: 36017630 | IF(2018) = 4.7
PDB [P13]: 7PT0

520: Structure of angiogenin dimer bound to double-stranded RNA.
Sievers K, Ficner R.
Acta Crystallogr F Struct Biol Commun (2022 Sep)78:330-337
DOI: 10.1107/s2053230x22008317 | PUBMED: 36048083
PDB [P14]: 8AF0

519: Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.
Truongvan N, Li S, Misra M, Kuhn M, Schindelin H.
Nat Commun. (2022 Aug)13:4789
DOI: 10.1038/s41467-022-32040-6 | PUBMED: 35970836 | IF(2022) = 14.9
PDB [P14]: 7PVN

518: Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives.
Nogués I, Sekula B, Angelaccio S, Grzechowiak M, Tramonti A, Contestabile R, Ruszkowski M.
Plant Physiol Biochem. (2022 Jul)187:37-49
DOI: 10.1016/j.plaphy.2022.07.025 | PUBMED: 35947902 | IF(2019) = 3.72
PDB [P14]: 7QPE

517: Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Pedersen H, Jensen RK, Hansen AG, Petersen SV, Thiel S, Laursen NS, Andersen GR.
Front Immunol. (2022 )13:872536
DOI: 10.3389/fimmu.2022.872536 | PUBMED: 35935935 | IF(2018) = 6.4
PDB [P13]: 7QIV

516: An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Baker YR, Thorpe C, Chen J, Poller LM, Cox L, Kumar P, Lim WF, Lie L, McClorey G, Epple S, Singleton D, McDonough MA, Hardwick JS, Christensen KE, Wood MJA, Hall JP, El-Sagheer AH, Brown T.
Nat Commun. (2022 Jul)13:4036
DOI: 10.1038/s41467-022-31636-2 | PUBMED: 35821218 | IF(2022) = 14.9
PDB [P13]: 7OZZ 7OOS

515: The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn²⁺ -binding domain essential for structural integrity and channel activity.
Sander S, Pick J, Gattkowski E, Fliegert R, Tidow H.
Protein Sci. (2022 Jun)31:e4320
DOI: 10.1002/pro.4320 | PUBMED: 35634784 | IF(2018) = 2.4
PDB [P14]: 7AOV 7RU7

514: Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin.
Vourloumis D, Mavridis I, Athanasoulis A, Temponeras I, Koumantou D, Giastas P, Mpakali A, Magrioti V, Leib J, van Endert P, Stratikos E, Papakyriakou A.
J Med Chem. (2022 Jul)65:10098-10117
DOI: 10.1021/acs.jmedchem.2c00904 | PUBMED: 35833347 | IF(2018) = 6.1
PDB [P13]: 7Z28 7ZYF

513: Structural Insights into the Role of β3 nAChR Subunit in the Activation of Nicotinic Receptors.
Giastas P, Papakyriakou A, Tsafaras G, Tzartos SJ, Zouridakis M.
Molecules. (2022 Jul)27:4642
DOI: 10.3390/molecules27144642 | PUBMED: 35889515 | IF(2020) = 3.3
PDB [P13]: 8A5U

512: The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity.
Schweininger J, Kriegel M, Häge S, Conrad M, Alkhashrom S, Lösing J, Weiler S, Tillmanns J, Egerer-Sieber C, Decker A, Lenac Roviš T, Eichler J, Sticht H, Marschall M, Muller YA.
J Biol Chem. (2022 Mar)298:101625
DOI: 10.1016/j.jbc.2022.101625 | PUBMED: 35074430 | IF(2018) = 4.1
PDB [P14]: 7PAB

511: Structural and biophysical studies of new L-asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn-amidohydrolase.
Loch JI, Klonecka A, Kądziołka K, Bonarek P, Barciszewski J, Imiolczyk B, Brzezinski K, Gilski M, Jaskolski M.
Acta Crystallogr D Struct Biol. (2022 Jul)78:911-926
DOI: 10.1107/s2059798322005691 | PUBMED: 35775990 | IF(2018) = 3.2
PDB [P13]: 7QYM 7QY6 7QYX

510: Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.
Bisiak F, Chrenková A, Zhang SD, Pedersen JN, Otzen DE, Zhang YE, Brodersen DE.
J Biol Chem. (2022 Jun)UNK:102142
DOI: 10.1016/j.jbc.2022.102142 | PUBMED: 35714769 | IF(2018) = 4.1
PDB [P13P14]: 7QOE 7QOC 7QOD

509: Crystal structures of the molecular class A β-lactamase TEM-171 and its complexes with tazobactam.
Grigorenko VG, Petrova TE, Carolan C, Rubtsova MY, Uporov IV, Pereira J, Chojnowski G, Samygina VR, Lamzin VS, Egorov AM.
Acta Crystallogr D Struct Biol. (2022 Jul)78:825-834
DOI: 10.1107/s2059798322004879 | PUBMED: 35775982 | IF(2018) = 3.2
PDB [P14]: 7QOR

508: Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803.
Malecki PH, Imiolczyk B, Barciszewski J, Czyrko-Horczak J, Sliwiak J, Gawel M, Wozniak K, Jaskolski M, Brzezinski K.
Acta Crystallogr D Struct Biol. (2022 Jul)78:865-882
DOI: 10.1107/s2059798322005605 | PUBMED: 35775986 | IF(2018) = 3.2
PDB [P13]: 7ZD7 7ZD8 7ZD9

507: Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors.
Burastero O, Defelipe LA, Gola G, Tateosian NL, Lopez ED, Martinena CB, Arcon JP, Traian MD, Wetzler DE, Bento I, Barril X, Ramirez J, Marti MA, Garcia-Alai MM, Turjanski AG.
J Med Chem. (2022 Jun)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c02012 | PUBMED: 35737472 | IF(2018) = 6.1
PDB [P14]: 7Q52

506: New aspects of DNA recognition by group II WRKY transcription factor revealed by structural and functional study of AtWRKY18 DNA binding domain.
Grzechowiak M, Ruszkowska A, Sliwiak J, Urbanowicz A, Jaskolski M, Ruszkowski M.
Int J Biol Macromol. (2022 Jun)213:589-601
DOI: 10.1016/j.ijbiomac.2022.05.186 | PUBMED: 35660042 | IF(2018) = 4.8
PDB [P14]: 7Z0U 7Z0R

505: Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1.
Sutinen A, Nguyen GTT, Raasakka A, Muruganandam G, Loris R, Ylikallio E, Tyynismaa H, Bartesaghi L, Ruskamo S, Kursula P.
FEBS Open Bio. (2022 May)UNK:pp. UNK
DOI: 10.1002/2211-5463.13422 | PUBMED: 35509130
PDB [P13]: 7YWD

504: Direct interaction of a chaperone-bound type III secretion substrate with the export gate.
Gilzer D, Schreiner M, Niemann HH.
Nat Commun. (2022 Jun)13:2858
DOI: 10.1038/s41467-022-30487-1 | PUBMED: 35654781 | IF(2022) = 14.9
PDB [P13]: 7QIJ

503: Ligandability Assessment of Human Glutathione Transferase M1-1 Using Pesticides as Chemical Probes.
Bodourian CS, Poudel N, Papageorgiou AC, Antoniadi M, Georgakis ND, Abe H, Labrou NE.
Int J Mol Sci. (2022 Mar)23:3606
DOI: 10.3390/ijms23073606 | PUBMED: 35408962 | IF(2018) = 4.2
PDB [P13]: 7BEU

502: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
Detry S, Andries J, Bloch Y, Gabay C, Clancy DM, Savvides SN
J Biol Chem. (2022 Apr)298:101908
DOI: 10.1016/j.jbc.2022.101908 | PUBMED: 35398099 | IF(2018) = 4.1
PDB [-P14]: 7AL7

501: A GH115 α-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis.
Wilkens C, Vuillemin M, Pilgaard B, Polikarpov I, Morth JP.
Acta Crystallogr D Struct Biol. (2022 May)78:658-668
DOI: 10.1107/s2059798322003527 | PUBMED: 35503213 | IF(2018) = 3.2
PDB [P14]: 7PUG

500: Family 1 Glycosyltransferase UGT706F8 from Zea mays Selectively Catalyzes the Synthesis of Silibinin 7-O-β-d-Glucoside.
Bidart GN, Putkaradze N, Fredslund F, Kjeldsen C, Ruiz AG, Duus JØ, Teze D, Welner DH.
ACS Sustain Chem Eng. (2022 Apr)10:5078-5083
DOI: 10.1021/acssuschemeng.1c07593 | PUBMED: 35493695
PDB [P14]: 7Q3S

499: Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.
Balandis B, Šimkūnas T, Paketurytė-Latvė V, Michailovienė V, Mickevičiūtė A, Manakova E, Gražulis S, Belyakov S, Kairys V, Mickevičius V, Zubrienė A, Matulis D.
Pharmaceuticals. (Basel) (2022 Apr)15:477
DOI: 10.3390/ph15040477 | PUBMED: 35455474
PDB [P13]: 7QGX 7QGZ

498: Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling.
Dubovskii PV, Dubova KM, Bourenkov G, Starkov VG, Konshina AG, Efremov RG, Utkin YN, Samygina VR.
Toxins. (Basel) (2022 Feb)14:149
DOI: 10.3390/toxins14020149 | PUBMED: 35202176
PDB [P14]: 7QFC

497: Letter to the editor: The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein.
Struwe MA, Clement B, Scheidig A.
Hepatol Commun. (2022 May)UNK:pp. UNK
DOI: 10.1002/hep4.1984 | PUBMED: 35560545
PDB [P14]: 7P41

496: Binding of VIVO2+, VIVOL+, VIVOL2 and VVO2L moieties to proteins: X-ray/theoretical characterization and biological implications.
Santos MFA, Sciortino G, Correia I, Fernandes ACP, Santos-Silva T, Pisanu F, Garribba E, Pessoa JC.
Chemistry. (2022 Apr)UNK:pp. UNK
DOI: 10.1002/chem.202200105 | PUBMED: 35486702 | IF(2019) = 4.9
PDB [P13]: 7Q0W

495: Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5′-monophosphate decarboxylase catalysis
Rindfleisch S, Krull M, Uranga J, et al. , Tittmann K
Nat Catal. 5: 332-341 (2022)
DOI: 10.1038/s41929-022-00771-w | PUBMED:
PDB [P13P14]: 7AM9 6YVL 6YVM 6YVK 6YVN 7ASQ 7OQI 7OUZ 7OTU 7OQK 7OQN 7OV0 7OQM 6ZX0 6ZX1 6YVO 6YWU 6ZX3 6ZX2 6YWT 6ZWY 6ZWZ 7OQF 7Q1H

494: The Structure of Bilirubin Oxidase from Bacillus pumilus Reveals a Unique Disulfide Bond for Site-Specific Direct Electron Transfer.
Gihaz S, Herzallh NS, Cohen Y, Bachar O, Fishman A, Yehezkeli O.
Biosensors. (Basel) (2022 Apr)12:258
DOI: 10.3390/bios12050258 | PUBMED: 35624560
PDB [P14]: 7Z5P

493: Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Pazicky S, Werle AA, Lei J, Löw C, Weininger U.
Cell Mol Life Sci. (2022 Feb)79:138
DOI: 10.1007/s00018-022-04179-4 | PUBMED: 35184231 | IF(2018) = 7.0
PDB [P13]: 7OXI 7OXK 7OXG 7OXJ 7OXH

492: A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function.
Minadakis MP, Mavreas KF, Neofytos DD, Paschou M, Kogkaki A, Athanasiou V, Mamais M, Veclani D, Iatrou H, Venturini A, Chrysina ED, Papazafiri P, Gimisis T.
Org Biomol Chem. (2022 Mar)20:2407-2423
DOI: 10.1039/d1ob02211c | PUBMED: 35119451
PDB [P13]: 7Q5I

491: GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Kroef V, Ruegenberg S, Horn M, Allmeroth K, Ebert L, Bozkus S, Miethe S, Elling U, Schermer B, Baumann U, Denzel MS.
Elife. (2022 Mar)11:pp. UNK
DOI: 10.7554/elife.69223 | PUBMED: 35229715 | IF(2018) = 7.6
PDB [P13]: 7NUU

490: Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations.
Sonani RR, Blat A, Dubin G.
Int J Biol Macromol. (2022 Feb)205:203-210
DOI: 10.1016/j.ijbiomac.2022.02.008 | PUBMED: 35149097 | IF(2018) = 4.8
PDB [P13]: 7Q84

489: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis.
Albert L, Nagpal J, Steinchen W, Zhang L, Werel L, Djokovic N, Ruzic D, Hoffarth M, Xu J, Kaspareit J, Abendroth F, Royant A, Bange G, Nikolic K, Ryu S, Dou Y, Essen LO, Vázquez O.
ACS Cent Sci. (2022 Jan)8:57-66
DOI: 10.1021/acscentsci.1c00434 | PUBMED: 35106373
PDB [P13]: 7AXP

488: Structural and Functional Characterization of Camelus dromedarius Glutathione Transferase M1-1.
Perperopoulou F, Poudel N, Papageorgiou AC, Ataya FS, Labrou NE.
Life. (Basel) (2022 Jan)12:pp. UNK
DOI: 10.3390/life12010106 | PUBMED: 35054499
PDB [P13]: 7OPY 7OPZ

487: Rare by Natural Selection: Disulfide-Bonded Supramolecular Antimicrobial Peptides.
Engelberg Y, Ragonis-Bachar P, Landau M.
Biomacromolecules. (2022 Jan)UNK:pp. UNK
DOI: 10.1021/acs.biomac.1c01353 | PUBMED: 35061360
PDB [P14]: 7NPQ

486: Identification of molecular basis that underlie enzymatic specificity of AzoRo from Rhodococcus opacus 1CP: A potential NADH:quinone oxidoreductase.
Ngo ACR, Qi J, Juric C, Bento I, Tischler D.
Arch Biochem Biophys. (2022 Mar)717:109123
DOI: 10.1016/j.abb.2022.109123 | PUBMED: 35051387
PDB [P13]: 7AWV

485: Widespread occurrence of covalent lysine-cysteine redox switches in proteins.
Rabe von Pappenheim F, Wensien M, Ye J, Uranga J, Irisarri I, de Vries J, Funk LM, Mata RA, Tittmann K.
Nat Chem Biol. (2022 Feb)UNK:pp. UNK
DOI: 10.1038/s41589-021-00966-5 | PUBMED: 35165445 | IF(2020) = 41.8
PDB [P14]: 7ODO 7ODQ 7O9G 7ODP 7OEY

484: Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2.
Mpakali A, Georgiadis D, Stratikos E, Giastas P.
ACS Med Chem Lett. (2022 Feb)13:218-224
DOI: 10.1021/acsmedchemlett.1c00582 | PUBMED: 35178178 | IF(2018) = 3.7
PDB [P13]: 7P7P 7PFS

483: A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat.
Geerds C, Bleymüller WM, Meyer T, Widmann C, Niemann HH.
Acta Crystallogr D Struct Biol. (2022 Mar)78:310-320
DOI: 10.1107/s2059798322000432 | PUBMED: 35234145 | IF(2018) = 3.2
PDB [P13]: 7PV9

482: Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.
Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A.
PLoS Pathog. (2022 Jan)18:e1010166
DOI: 10.1371/journal.ppat.1010166 | PUBMED: 35007292 | IF(2018) = 6.1
PDB [P13]: 6T5I

481: Best practices for time-resolved serial synchrotron crystallography. o
Schulz EC, Yorke BA, Pearson AR, Mehrabi P.
Acta Crystallogr D Struct Biol. 2022;78(Pt 1):14-29.
DOI: 10.1107/S2059798321011621 | PUBMED: 34981758 | IF(2018) = 3.2
PDB [P14]:

Number of publications for 2022: 51

2021

480: Structure, dynamics, and function of SrnR, a transcription factor for nickel-dependent gene expression.
Mazzei L, Musiani F, Żerko S, Koźminski W, Cianci M, Beniamino Y, Ciurli S, Zambelli B.
Metallomics (2021 Dec)13:mfab069
DOI: 10.1093/mtomcs/mfab069 | PUBMED: 34850061
PDB [P13]: 7P6F

479: The Bacteroidetes Aequorivita sp. and Kaistella jeonii Produce Promiscuous Esterases With PET-Hydrolyzing Activity.
Zhang H, Perez-Garcia P, Dierkes RF, Applegate V, Schumacher J, Chibani CM, Sternagel S, Preuss L, Weigert S, Schmeisser C, Danso D, Pleiss J, Almeida A, Höcker B, Hallam SJ, Schmitz RA, Smits SHJ, Chow J, Streit WR.
Front Microbiol (2021 )12:803896
DOI: 10.3389/fmicb.2021.803896 | PUBMED: 35069509
PDB [P13]: 7PZJ

478: Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX.
Zakšauskas A, Čapkauskaitė E, Paketurytė-Latvė V, Smirnov A, Leitans J, Kazaks A, Dvinskis E, Stančaitis L, Mickevičiūtė A, Jachno J, Jezepčikas L, Linkuvienė V, Sakalauskas A, Manakova E, Gražulis S, Matulienė J, Tars K, Matulis D.
Int J Mol Sci (2021 Dec)23:pp. UNK
DOI: 10.3390/ijms23010130 | PUBMED: 35008553
PDB [P13]: 7Q0D 7PUU 7PUW 7Q0E 7PUV 7Q0C

477: Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii
Marchetti GM, Fusser F, Singh RK, Brummel M, Koch O, Kummel D, Hippler M
J Struct Biol (2021 Dec)214:107829
DOI: 10.1016/j.jsb.2021.107829 | PUBMED: 34974142
PDB [P13]: 7P9D 7P9E

476: Broken symmetry between RNA enantiomers in a crystal lattice.
Kiliszek A, Błaszczyk L, Bejger M, Rypniewski W.
Nucleic Acids Res (2021 Jun)UNK:pp. UNK
DOI: 10.1093/nar/gkab480 | PUBMED: 34107036
PDB [P13]: 7A9T 7A9O 6ZWU 6ZPF 6ZX5 6ZR1 6ZRL 6ZQ9 6ZW3 6ZRS 7A9N

475: Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Ornik-Cha A, Wilhelm J, Kobylka J, Sjuts H, Vargiu AV, Malloci G, Reitz J, Seybert A, Frangakis AS, Pos KM.
Nat Commun. (2021 Nov)12:6919
DOI: 10.1038/s41467-021-27146-2 | PUBMED: 34824229 | IF(2022) = 14.9
PDB [P13P14]: 7B8R 7B8S

474: Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP.
J Med Chem (2021 Nov)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c00804 | PUBMED: 34807584
PDB [P13]: 6YAT

473: The elusive Rhizobium etli L-asparaginase has a novel fold and peculiar active site
Loch JI, Imiolczyk B, Sliwiak J, Wantuch A, Bejger M, Gilski M, Jaskolski M
Nat Commun. (2021 Nov)12:6717
DOI: 10.1038/s41467-021-27105-x | PUBMED: 34795296 | IF(2022) = 14.9
PDB [P13]: 7OS5 7OS3 7OS6

472: Role of hydrogen bond alternation and charge transfer states in photoactivation of the Orange Carotenoid Protein.
Yaroshevich IA, Maksimov EG, Sluchanko NN, Zlenko DV, Stepanov AV, Slutskaya EA, Slonimskiy YB, Botnarevskii VS, Remeeva A, Gushchin I, Kovalev K, Gordeliy VI, Shelaev IV, Gostev FE, Khakhulin D, Poddubnyy VV, Gostev TS, Cherepanov DA, Polívka T, Kloz M, Friedrich T, Paschenko VZ, Nadtochenko VA, Rubin AB, Kirpichnikov MP.
Communications Biology. 2021 May;4(1):539.
DOI: 10.1038/s42003-021-02022-3. | PUBMED: 33972665
PDB [P14]: 6T6O 6T6M 6T6K

471: Homogeneous batch micro-crystallization of proteins from ammonium sulfate.
Stohrer C, Horrell S, Meier S, et al.
Acta crystallographica. Section D, Structural Biology. 2021 Feb;77(Pt 2):194-204.
DOI: 10.1107/s2059798320015454. | PUBMED: 33559608; PMCID: PMC7869895.
PDB [P14]:

470: DYW domain structures imply an unusual regulation principle in plant organellarRNA editing catalysis.
Takenaka M, Takenaka S, Barthel T, Frink B, Haag S, Verbitskiy D, Oldenkott B, Schallenberg-Rudinger M, Feiler CG, Weiss MS, Palm GJ, Weber G,
Nat Catal. 2021 Jun;4(6):510-522. doi: 10.1038/s41929-021-00633-x. Epub 2021 Jun 21.
DOI: 10.1038/s41929-021-00633-x [doi] | PUBMED: 34712911
PDB [P13]:

469: Conformational interplay in hybrid peptide-helical aromatic foldamer macrocycles.
Dengler S, Mandal PK, Allmendinger L, Douat C, Huc I,
Chem Sci. 2021 Jul 27;12(33):11004-11012. doi: 10.1039/d1sc03640h. eCollection2021 Aug 25.
DOI: 10.1039/d1sc03640h [doi] | PUBMED: 34522297
PDB [P13]:

468: Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C.
Wallerstein J, Ekberg V, Ignjatovic MM, Kumar R, Caldararu O, Peterson K, Wernersson S, Brath U, Leffler H, Oksanen E, Logan DT, Nilsson UJ, Ryde U, Akke M,
JACS Au. 2021 Apr 1;1(4):484-500. doi: 10.1021/jacsau.0c00094. eCollection 2021Apr 26.
DOI: 10.1021/jacsau.0c00094 [doi] | PUBMED: 34467311
PDB [P13]: 6RZF 6RZG 6RZH

467: Structural Characterization of EnpA D,L-Endopeptidase from Enterococcus faecalis Prophage Provides Insights into Substrate Specificity of M23 Peptidases.
Malecki PH, Mitkowski P, Jagielska E, Trochimiak K, Mesnage S, Sabala I,
Int J Mol Sci. 2021 Jul 1;22(13). pii: ijms22137136. doi: 10.3390/ijms22137136.
DOI: 10.3390/ijms22137136 | PUBMED: 34281200 | IF(2018) = 4.2
PDB [P13]:

466: Calmodulin complexes with brain and muscle creatine kinase peptides.
Sprenger J, Trifan A, Patel N, Vanderbeck A, Bredfelt J, Tajkhorshid E, Rowlett R, Lo Leggio L, Akerfeldt KS, Linse S,
Curr Res Struct Biol. 2021 May 19;3:121-132. doi: 10.1016/j.crstbi.2021.05.001.eCollection 2021.
DOI: 10.1016/j.crstbi.2021.05.001 [doi] | PUBMED: 34235492
PDB [P13P14]:

465: Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase.
Nowacka M, Nowak E, Czarnocki-Cieciura M, Jackiewicz J, Skowronek K, Szczepanowski RH, Wohrl BM, Nowotny M,
J Virol. 2021 Aug 25;95(18):e0084821. doi: 10.1128/JVI.00848-21. Epub 2021 Aug25.
DOI: 10.1128/JVI.00848-21 [doi] | PUBMED: 34232702 | IF(2018) = 4.3
PDB [P13]: 7O0G

464: Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-NaphthalimideDerivatives as Potential Anticancer Agents.
Rykowski S, Gurda-Wozna D, Orlicka-Plocka M, Fedoruk-Wyszomirska A, Giel-Pietraszuk M, Wyszko E, Kowalczyk A, Staczek P, Bak A, Kiliszek A, Rypniewski W, Olejniczak AB,
Int J Mol Sci. 2021 Mar 9;22(5). pii: ijms22052772. doi: 10.3390/ijms22052772.
DOI: 10.3390/ijms22052772 | PUBMED: 33803403 | IF(2018) = 4.2
PDB [P13]:

463: Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
Wortmann L, Bräuer N,Holton SJ, Irlbacher H, Weiske J, Lechner C, Meier R, Karén J, Siöberg CB, Pütter V, Christ CD, Ter Laak A, Lienau P, Lesche R, Nicke B, Cheung SH, Bauser M, Haegebarth A, von Nussbaum F, Mumberg D, Lemos C.
J Med Chem. 2021 Nov 11;64(21):15883-15911.
DOI: 10.1021/acs.jmedchem.1c01245. | PUBMED: 34699202. | IF(2018) = 6.1
PDB [P14]: 6YM5

462: An automated platform for structural analysis of membrane proteins through serial crystallography.
Healey RD, Basu S, Humm AS, Leyrat C, Cong X, Golebiowski J, Dupeux F, Pica A, Granier S, Márquez JA.
Cell Rep Methods.
DOI: 10.1016/j.crmeth.2021.100102. | PUBMED: 34723237
PDB [P14]: 6YXD

461: Wilavidin* - a novel member of the avidin family that forms unique biotin-binding hexamers.
Avraham O, Bayer EA, Livnah O.
FEBS J.
DOI: 10.1111/febs.16259. | PUBMED: 34726340 | IF(2018) = 4.7
PDB [P13]: 7OUQ

460: Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Dolot R, Krakowiak A, Kaczmarek R, Włodarczyk A, Pichlak M, Nawrot B.
Biochim Biophys Acta Gen Subj (2021 Nov)1865:129968
DOI: 10.1016/j.bbagen.2021.129968 | PUBMED: 34329705
PDB [P13]: 6YPR 6YQD 6YPX

459: Insights into Broad-Specificity Starch Modification from the Crystal Structure of Limosilactobacillus Reuteri NCC 2613 4,6-α-Glucanotransferase GtfB.
Pijning T, Gangoiti J, Te Poele EM, Börner T, Dijkhuizen L.
J Agric Food Chem. 2021 Oct 28.
DOI: 10.1021/acs.jafc.1c05657. | PUBMED: 34708648.
PDB [P14]: 7P38

458: Profiling cellular diversity in sponges informs animal cell type and nervous system evolution.
Musser JM, Schippers KJ, Nickel M, Mizzon G, Kohn AB, Pape C, Ronchi P, Papadopoulos N, Tarashansky AJ, Hammel JU, Wolf F, Liang C, Hernández-Plaza A, Cantalapiedra CP, Achim K, Schieber NL, Pan L, Ruperti F, Francis WR, Vargas S, Kling S, Renkert M, Polikarpov M, Bourenkov G, Feuda R, Gaspar I, Burkhardt P, Wang B, Bork P, Beck M, Schneider TR, Kreshuk A, Wörheide G, Huerta-Cepas J, Schwab Y, Moroz LL, Arendt D.
Science. 2021 Nov 5;374(6568):717-723.
DOI: 10.1126/science.abj2949. | PUBMED: 34735222. | IF(2018) = 41.1
PDB [P14]:

457: Structural basis of cytokine-mediated activation of ALK family receptors.
De Munck S, Provost M, Kurikawa M, Omori I, Mukohyama J, Felix J, Bloch Y, Abdel-Wahab O, Bazan JF, Yoshimi A, Savvides SN.
Nature. (2021 Oct 13). Epub ahead of print
DOI: 10.1038/s41586-021-03959-5 | PUBMED: 34646012 | IF(2018) = 43.1
PDB [P13P14]: 7NX4 7NX2 7NX1

456: Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation-π interaction.
Helfrich F, Scheidig AJ.
Acta Crystallogr D Struct Biol (2021 Oct)77:1317-1335
DOI: 10.1107/s2059798321008937 | PUBMED: 34605434
PDB [P13P14]: 6Y87 6SEP 6S6G 4W8G 6S49 6S4D 6S65 6S3X 6S72

455: 3D Domain Swapping Dimerization of the Receiver Domain of Cytokinin Receptor CRE1 From Arabidopsis thaliana and Medicago truncatula.
Tran LH, Urbanowicz A, Jasiński M, Jaskolski M, Ruszkowski M.
Front Plant Sci (2021 )12:756341
DOI: 10.3389/fpls.2021.756341 | PUBMED: 34630499
PDB [P13]: 7P8E 7P8D 7P8C

454: Medicinal Au(I) compounds targeting urease as prospective antimicrobial agents: unveiling the structural basis for enzyme inhibition.
Mazzei L, Massai L, Cianci M, Messori L, Ciurli S.
Dalton Trans. 2021;50(40):14444-14452.
DOI: 10.1039/d1dt02488d | PUBMED: 34585201
PDB [P13]: 7P7N 7P7O

453: Kinetic and structural analysis of the inactivation of urease by mixed-ligand phosphine halide Ag(I) complexes.
Mazzei L, Cirri D, Cianci M, Messori L, Ciurli S.
J Inorg Biochem. (2021 May)218:111375
DOI: 10.1016/j.jinorgbio.2021.111375 | PUBMED: 33711632
PDB [P13]: 7B58 7B5A 7B59

452: Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket.
Grininger C, Leypold M, Aschauer P, Pavkov-Keller T, Riegler-Berket L, Breinbauer R, Oberer M.
Biomolecules. (2021 Sep)11:pp. UNK
DOI: 10.3390/biom11091299 | PUBMED: 34572512 | IF(2019) = 4.7
PDB [P13]: 7OZM

451: The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes.
Osorio-Valeriano M, Altegoer F, Das CK, Steinchen W, Panis G, Connolley L, Giacomelli G, Feddersen H, Corrales-Guerrero L, Giammarinaro PI, Hanßmann J, Bramkamp M, Viollier PH, Murray S, Schäfer LV, Bange G, Thanbichler M.
Mol Cell. (2021 Oct)81:3992-4007.e10
DOI: 10.1016/j.molcel.2021.09.004 | PUBMED: 34562373 | IF(2018) = 14.5
PDB [P14]: 7BNR

450: Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Nair RM, Seenivasan A, Liu B, Chen D, Lowe ED, Lorenz S.
ACS Chem Biol. (2021 Sep)16:1615-1621
DOI: 10.1021/acschembio.1c00433 | PUBMED: 34403242 | IF(2019) = 4.43
PDB [P13]: 6XZ1

449: Crystal structure of Z-DNA in complex with the polyamine putrescine and potassium cations at ultra-high resolution.
Drozdzal P, Gilski M, Jaskolski M.
Acta Crystallogr B Struct Sci Cryst Eng Mater. (2021 Jun)77:331-338
DOI: 10.1107/s2052520621002663 | PUBMED: 34096514
PDB [P13]: 7ATG

448: Considerations Regarding Activity Determinants of Fungal Polyphenol Oxidases Based on Mutational and Structural Studies.
Nikolaivits E, Valmas A, Dedes G, Topakas E, Dimarogona M.
Appl Environ Microbiol. (2021 May)87:pp. UNK
DOI: 10.1128/aem.00396-21 | PUBMED: 33741634
PDB [P14]: 6Z1S

447: Engineering a Highly Efficient Carboligase for Synthetic One-Carbon Metabolism.
Nattermann M, Burgener S, Pfister P, Chou A, Schulz L, Lee SH, Paczia N, Zarzycki J, Gonzalez R, Erb TJ.
ACS Catal. (2021 May)11:5396-5404
DOI: 10.1021/acscatal.1c01237 | PUBMED: 34484855 | IF(2018) = 12.1
PDB [P13]: 7B2E

446: Glycogen phosphorylase revisited: extending the resolution of the R- and T-state structures of the free enzyme and in complex with allosteric activators.
Leonidas DD, Zographos SE, Tsitsanou KE, Skamnaki VT, Stravodimos G, Kyriakis E.
Acta Crystallogr F Struct Biol Commun. (2021 Sep)77:303-311
DOI: 10.1107/s2053230x21008542 | PUBMED: 34473107 | IF(2019) = 0.97
PDB [P13]: 7P7D

445: Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Koelmel W, Kuper J, Kisker C.
Sci Rep. (2021 Aug)11:17038
DOI: 10.1038/s41598-021-95186-1 | PUBMED: 34426585 | IF(2018) = 4.1
PDB [P14]: 7BMR 7BMU 7BMO 7BMQ

444: BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture.
Bandera AM, Bartho J, Lammens K, Drexler DJ, Kleinschwärzer J, Hopfner KP, Witte G.
Nucleic Acids Res. (2021 Sep)49:10166-10177
DOI: 10.1093/nar/gkab736 | PUBMED: 34432045 | IF(2018) = 11.1
PDB [P13P14]: 7B5U 7B5T 7B5W

443: Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.
Fauser J, Gulen B, Pogenberg V, Pett C, Pourjafar-Dehkordi D, Krisp C, Höpfner D, König G, Schlüter H, Feige MJ, Zacharias M, Hedberg C, Itzen A.
Nat Commun. (2021 Apr)12:2426
DOI: 10.1038/s41467-021-22596-0 | PUBMED: 33893288 | IF(2022) = 14.9
PDB [P13]: 6ZMD

442: Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli.
Hamborg L, Granata D, Olsen JG, Roche JV, Pedersen LE, Nielsen AT, Lindorff-Larsen K, Teilum K.
Commun Biol. (2021 Aug)4:980
DOI: 10.1038/s42003-021-02490-7 | PUBMED: 34408246 | IF(2019) = 12.1
PDB [P13P14]: 7A3M 7AON 7AOK

441: Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.
Masuyer G, Davies JR, Stenmark P.
Int J Mol Sci. (2021 Aug)22:pp. UNK
DOI: 10.3390/ijms22158315 | PUBMED: 34361086 | IF(2018) = 4.2
PDB [P13]: 7OVW

440: Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria.
Freischem S, Grimm I, López-Pérez A, Willbold D, Klenke B, Vuong C, Dingley AJ, Weiergräber OH.
Biomolecules. (2021 Jul)11:pp. UNK
DOI: 10.3390/biom11071057 | PUBMED: 34356681 | IF(2019) = 4.7
PDB [P13]: 7ONY 7ONZ

439: Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA.
Blersch KF, Burchert JP, August SC, Welp L, Neumann P, Köster S, Urlaub H, Ficner R.
RNA Biol. (2021 May)UNK:1-14
DOI: 10.1080/15476286.2021.1925477 | PUBMED: 34006170
PDB [P13]: 7NZJ 7NYB

438: Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers.
Schweininger J, Scherer M, Rothemund F, Schilling EM, Wörz S, Stamminger T, Muller YA.
PLoS Pathog. (2021 Aug)17:e1009863
DOI: 10.1371/journal.ppat.1009863 | PUBMED: 34370791 | IF(2018) = 6.1
PDB [P13]: 6TGZ

437: Structure and mechanism of secondary sulfonamide binding to carbonic anhydrases.
Baronas D, Dudutienė V, Paketurytė V, Kairys V, Smirnov A, Juozapaitienė V, Vaškevičius A, Manakova E, Gražulis S, Zubrienė A, Matulis D.
Eur Biophys J. (2021 Jul)UNK:pp. UNK
DOI: 10.1007/s00249-021-01561-1 | PUBMED: 34328515
PDB [P13P14]: 7AES 7AEQ 7AGN

436: Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.
Uusitalo M, Klenow MB, Laulumaa S, Blakeley MP, Simonsen AC, Ruskamo S, Kursula P.
FEBS J. (2021 Jun)UNK:pp. UNK
DOI: 10.1111/febs.16079 | PUBMED: 34138518 | IF(2018) = 4.7
PDB [P13]: 7NRW

435: Conformational changes of loops highlight a potential binding site in Rhodococcus equi VapB.
Geerds C, Haas A, Niemann HH.
Acta Crystallogr F Struct Biol Commun. (2021 Aug)77:246-253
DOI: 10.1107/s2053230x2100738x | PUBMED: 34341190 | IF(2019) = 0.97
PDB [P14]: 7B1Z

434: Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis β-oxidation trifunctional enzyme.
Dalwani S, Lampela O, Leprovost P, Schmitz W, Juffer AH, Wierenga RK, Venkatesan R.
J Struct Biol. (2021 Aug)213:107776
DOI: 10.1016/j.jsb.2021.107776 | PUBMED: 34371166 | IF(2018) = 3.8
PDB [P13]: 7O4T

433: The induction mechanism of the flavonoid-responsive regulator FrrA.
Werner N, Werten S, Hoppen J, Palm GJ, Göttfert M, Hinrichs W.
FEBS J. (2021 Jul)UNK:pp. UNK
DOI: 10.1111/febs.16141 | PUBMED: 34314575 | IF(2018) = 4.7
PDB [P13]: 6G8H 6G8G

432: NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
Baggio C, Kulinich A, Dennys CN, Rodrigo R, Meyer K, Ethell I, Pellecchia M.
J Med Chem. (2021 Jul)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c00608 | PUBMED: 34293864 | IF(2018) = 6.1
PDB [P13]: 7OFV

431: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Verstraete K, Verschueren KHG, Dansercoer A, Savvides SN.
Nat Struct Mol Biol. 2021 Aug;28(8):636-638. Epub 2021 Jul 22.
DOI: 10.1038/s41594-021-00624-3 | PUBMED: 34294920 | IF(2019) = 11.7
PDB [P14]: 6ZNW

430: Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography.
Geier B, Oetjen J, Ruthensteiner B, Polikarpov M, Gruber-Vodicka HR, Liebeke M.
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2023773118.
DOI: 10.1073/pnas.2023773118. | PUBMED: 34183413 | IF(2019) = 9.4
PDB [P14]:

429: Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps.
Kelpšas V, Caldararu O, Blakeley MP, Coquelle N, Wierenga RK, Ryde U, von Wachenfeldt C, Oksanen E.
IUCrJ. (2021 Jul)8:633-643
DOI: 10.1107/s2052252521004619 | PUBMED: 34258011 | IF(2020) = 4
PDB [P14]: 7AZ9 7AZA

428: Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii.
Krska D, Mazurkewich S, Brown HA, Theibich Y, Poulsen JN, Morris AL, Koropatkin NM, Lo Leggio L, Larsbrink J.
Biochemistry. (2021 Jul)60:2206-2220
DOI: 10.1021/acs.biochem.1c00305 | PUBMED: 34180241 | IF(2018) = 3.0
PDB [P13]: 7NWO 7NWQ

427: Insights into the Protein Ruthenation Mechanism by Antimetastatic Metallodrugs: High-Resolution X-ray Structures of the Adduct Formed between Hen Egg-White Lysozyme and NAMI-A at Various Time Points.
Chiniadis L, Giastas P, Bratsos I, Papakyriakou A.
Inorg Chem. (2021 Jul)60:10729-10737
DOI: 10.1021/acs.inorgchem.1c01441 | PUBMED: 34197115 | IF(2019) = 4
PDB [P13]: 7BCX 7BD0 7BDM 7BCU

426: Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners.
Marcelot A, Petitalot A, Ropars V, Le Du MH, Samson C, Dubois S, Hoffmann G, Miron S, Cuniasse P, Marquez JA, Thai R, Theillet FX, Zinn-Justin S.
Nucleic Acids Res. (2021 Apr)49:3841-3855
DOI: 10.1093/nar/gkab184 | PUBMED: 33744941 | IF(2018) = 11.1
PDB [P14]: 7ABM

425: A computationally designed β-amino acid-containing miniprotein.
Bejger M, Fortuna P, Drewniak-Switalska M, Plewka J, Rypniewski W, Berlicki Ł.
Chem Commun. (Camb) (2021 Jun)57:6015-6018
DOI: 10.1039/d1cc02192c | PUBMED: 34032224 | IF(2019) = 5.996
PDB [P13]: 7ARR 7ARS

424: Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan.
Sprenger J, Lawson CL, von Wachenfeldt C, Lo Leggio L, Carey J.
Acta Crystallogr F Struct Biol Commun. (2021 Jul)77:215-225
DOI: 10.1107/s2053230x21006142 | PUBMED: 34196612 | IF(2019) = 0.97
PDB [P13]: 7OS9

423: Snapshots of a Non-Canonical RdRP in Action.
Ferrero DS, Falqui M, Verdaguer N.
Viruses. (2021 Jun)13:pp. UNK
DOI: 10.3390/v13071260 | PUBMED: 34203380 | IF(2020) = 5.048
PDB [P13]: 7OMA 7OM7

422: Structure of the mycobacterial ESX-5 type VII secretion system pore complex.
Beckham KSH, Ritter C, Chojnowski G, Ziemianowicz DS, Mullapudi E, Rettel M, Savitski MM, Mortensen SA, Kosinski J, Wilmanns M.
Sci Adv. 2021 Jun 25;7(26):eabg9923.
DOI: 10.1126/sciadv.abg9923 | PUBMED: 34172453 | IF(2018) = 12.5
PDB [P13]: 7B7J

421: Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1.
Orth B, Sander B, Möglich A, Diederichs K, Eilers M, Lorenz S.
Structure. (2021 Jun)UNK:pp. UNK
DOI: 10.1016/j.str.2021.06.005 | PUBMED: 34186024 | IF(2018) = 4.9
PDB [P13]: 7AZW

420: Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.
Samarina N, Ssebyatika G, Tikla T, Waldmann JY, Abere B, Nanna V, Marasco M, Carlomagno T, Krey T, Schulz TF.
PLoS Pathog. (2021 Jun)17:e1009635
DOI: 10.1371/journal.ppat.1009635 | PUBMED: 34143834 | IF(2018) = 6.1
PDB [P13]: 7NXE

419: Allosteric drug transport mechanism of multidrug transporter AcrB.
Tam HK, Foong WE, Oswald C, Herrmann A, Zeng H, Pos KM.
Nat Commun. (2021 Jun)12:3889
DOI: 10.1038/s41467-021-24151-3 | PUBMED: 34188038 | IF(2022) = 14.9
PDB [P13]: 6ZOG

418: Discovery of fungal surface NADases predominantly present in pathogenic species.
Strømland Ø, Kallio JP, Pschibul A, Skoge RH, Harðardóttir HM, Sverkeli LJ, Heinekamp T, Kniemeyer O, Migaud M, Makarov MV, Gossmann TI, Brakhage AA, Ziegler M.
Nat Commun. (2021 Mar)12:1631
DOI: 10.1038/s41467-021-21307-z | PUBMED: 33712585 | IF(2022) = 14.9
PDB [P13]: 6YGE

417: Mutation-induced dimerization of transforming growth factor-β-induced protein may drive protein aggregation in granular corneal dystrophy.
Nielsen NS, Gadeberg TAF, Poulsen ET, Harwood SL, Weberskov CE, Pedersen JS, Andersen GR, Enghild JJ.
J Biol Chem. (2021 Jun)297:100858
DOI: 10.1016/j.jbc.2021.100858 | PUBMED: 34097874 | IF(2018) = 4.1
PDB [P13P14]: 7AS7 7ASC 7ASG

416: Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2.
Czapinska H, Winiewska-Szajewska M, Szymaniec-Rutkowska A, Piasecka A, Bochtler M, Poznański J.
J Phys Chem B. (2021 Mar)125:2491-2503
DOI: 10.1021/acs.jpcb.0c10264 | PUBMED: 33689348
PDB [P14]: 6TLU 6TLS 6TLV 6TLL 6TLO 6TLR 6TLW

415: Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin.
Sponga A, Arolas JL, Schwarz TC, Jeffries CM, Rodriguez Chamorro A, Kostan J, Ghisleni A, Drepper F, Polyansky A, De Almeida Ribeiro E, Pedron M, Zawadzka-Kazimierczuk A, Mlynek G, Peterbauer T, Doto P, Schreiner C, Hollerl E, Mateos B, Geist L, Faulkner G, Kozminski W, Svergun DI, Warscheid B, Zagrovic B, Gautel M, Konrat R, Djinović-Carugo K.
Sci Adv. 2021 May 28; 7(22):eabg7653.
DOI: 10.1126/sciadv.abg7653 | PUBMED: 34049882 | IF(2018) = 12.5
PDB [P14]: 7A8T

414: Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Sekulovski S, Devant P, Panizza S, Gogakos T, Pitiriciu A, Heitmeier K, Ramsay EP, Barth M, Schmidt C, Tuschl T, Baas F, Weitzer S, Martinez J, Trowitzsch S.
Nat Commun. 2021 Sep 28;12(1):5610.
DOI: 10.1038/s41467-021-25870-3 | PUBMED: 34584079 | IF(2022) = 14.9
PDB [P14]: 6Z9U

413: Low Carbon Footprint Recycling of Post-Consumer PET Plastic with a Metagenomic Polyester Hydrolase.
Sonnendecker C, Oeser J, Richter PK, Hille P, Zhao Z, Fischer C, Lippold H, Blázquez-Sánchez P, Engelberger F, Ramírez-Sarmiento CA, Oeser T, Lihanova Y, Frank R, Jahnke HG, Billig S, Abel B, Sträter N, Matysik J, Zimmermann W.
ChemSusChem. (2021 Jun)UNK:pp. UNK
DOI: 10.1002/cssc.202101062 | PUBMED: 34129279 | IF(2019) = 7.692
PDB [P14]: 7NEI

412: Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
Nguyen D, Xie X, Jakobi S, Terwesten F, Metz A, Nguyen TXP, Palchykov VA, Heine A, Reuter K, Klebe G.
ACS Chem Biol. (2021 Jun)16:1090-1098
DOI: 10.1021/acschembio.1c00296 | PUBMED: 34081441 | IF(2019) = 4.43
PDB [P13P14]: 7A4X 7ADN

411: A simple vapor-diffusion method enables protein crystallization inside the HARE serial crystallography chip.
Norton-Baker B, Mehrabi P, Boger J, Schönherr R, von Stetten D, Schikora H, Kwok AO, Martin RW, Miller RJD, Redecke L, Schulz EC.
Acta Crystallogr D Struct Biol. (2021 Jun)77:820-834
DOI: 10.1107/s2059798321003855 | PUBMED: 34076595 | IF(2018) = 3.2
PDB [P14]: 7NJH 7NJG 7NJJ 7NJI 7NJE 7NKF 7NJF

410: Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum.
Švecová L, Østergaard LH, Skálová T, Schnorr KM, Koval' T, Kolenko P, Stránský J, Sedlák D, Dušková J, Trundová M, Hašek J, Dohnálek J.
Acta Crystallogr D Struct Biol. (2021 Jun)77:755-775
DOI: 10.1107/s2059798321003533 | PUBMED: 34076590 | IF(2018) = 3.2
PDB [P13]: 7AA2 6ZE5 6ZE2

409: Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent.
Narczyk M, Mioduszewski Ł, Oksiejuk A, Winiewska-Szajewska M, Wielgus-Kutrowska B, Gojdź A, Cieśla J, Bzowska A.
Sci Rep. (2021 May)11:11144
DOI: 10.1038/s41598-021-90472-4 | PUBMED: 34045551 | IF(2018) = 4.1
PDB [P14]: 6XZ2

408: Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.
Yperman K, Papageorgiou AC, Merceron R, De Munck S, Bloch Y, Eeckhout D, Jiang Q, Tack P, Grigoryan R, Evangelidis T, Van Leene J, Vincze L, Vandenabeele P, Vanhaecke F, Potocký M, De Jaeger G, Savvides SN, Tripsianes K, Pleskot R, Van Damme D.
Nat Commun. (2021 May)12:3050
DOI: 10.1038/s41467-021-23314-6 | PUBMED: 34031427 | IF(2022) = 14.9
PDB [P14]: 6YIG

407: TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D.
Mol Cell. (2021 Apr)UNK:pp. UNK
DOI: 10.1016/j.molcel.2021.04.019 | PUBMED: 33974911 | IF(2018) = 14.5
PDB [P13]: 7A0N

406: Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Wurm JP, Sung S, Kneuttinger AC, Hupfeld E, Sterner R, Wilmanns M, Sprangers R.
Nat Commun. (2021 May)12:2748
DOI: 10.1038/s41467-021-22968-6 | PUBMED: 33980881 | IF(2022) = 14.9
PDB [P13]: 7AC8

405: A lysine-cysteine redox switch with an NOS bridge regulates enzyme function.
Wensien M, von Pappenheim FR, Funk LM, Kloskowski P, Curth U, Diederichsen U, Uranga J, Ye J, Fang P, Pan KT, Urlaub H, Mata RA, Sautner V, Tittmann K.
Nature. 2021 May;593(7859):460-464. Epub 2021 May 5.
DOI: 10.1038/s41586-021-03513-3 | PUBMED: 33953398 | IF(2018) = 43.1
PDB [P14]: 6ZWJ 7BBW 7BBX 6ZWF 6ZX4 6ZWH

404: The crystal structure of the Ca²⁺-ATPase 1 from Listeria monocytogenes reveals a pump primed for dephosphorylation.
Basse Hansen S, Dyla M, Neumann C, Meldgaard Hoegh Quistgaard E, Lauwring Andersen J, Kjaergaard M, Nissen P.
J Mol Biol. (2021 Apr)UNK:167015
DOI: 10.1016/j.jmb.2021.167015 | PUBMED: 33933469 | IF(2018) = 5.1
PDB [P13]: 6ZHH 6ZHG

403: The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan.
Imae R, Kuwabara N, Manya H, Tanaka T, Tsuyuguchi M, Mizuno M, Endo T, Kato R.
Genes Cells. (2021 Apr)UNK:pp. UNK
DOI: 10.1111/gtc.12853 | PUBMED: 33893702 | IF(2019) = 1.65
PDB [P14]: 7E9K

402: Serendipitous crystallization of E. coli HPII catalase, a sequel to "the tale usually not told".
Grzechowiak M, Sekula B, Jaskolski M, Ruszkowski M.
Acta Biochim Pol. (2021 Jan) 68:29-31
DOI: 10.18388/abp.2020_5501 | PUBMED: 33485289
PDB [P13]: 6ZTV 6ZTW

401: X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schluenzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A.
Science. (2021 May 7) 372(6542):642-646
DOI: 10.1126/science.abf7945 | PUBMED: 33811162 | IF(2018) = 41.1
PDB [P14]: 7AXO

400: Crystal structures of the EVE-HNH endonuclease VcaM4I in the presence and absence of DNA.
Pastor M, Czapinska H, Helbrecht I, Krakowska K, Lutz T, Xu SY, Bochtler M.
Nucleic Acids Res. (2021 Feb)49:1708-1723
DOI: 10.1093/nar/gkaa1218 | PUBMED: 33450012 | IF(2018) = 11.1
PDB [P13]: 6YKF

399: The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins.
Röllen K, Granzin J, Remeeva A, Davari MD, Gensch T, Nazarenko VV, Kovalev K, Bogorodskiy A, Borshchevskiy V, Hemmer S, Schwaneberg U, Gordeliy V, Jaeger KE, Batra-Safferling R, Gushchin I, Krauss U.
J Biol Chem. (2021 Apr)UNK:100662
DOI: 10.1016/j.jbc.2021.100662 | PUBMED: 33862085 | IF(2018) = 4.1
PDB [P13P14]: 7AB7

398: Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison.
Mehrabi P, Bücker R, Bourenkov G, Ginn HM, von Stetten D, Müller-Werkmeister HM, Kuo A, Morizumi T, Eger BT, Ou WL, Oghbaey S, Sarracini A, Besaw JE, Pare-Labrosse O, Meier S, Schikora H, Tellkamp F, Marx A, Sherrell DA, Axford D, Owen RL, Ernst OP, Pai EF, Schulz EC, Miller RJD.
Sci Adv. (2021 Mar 17) 7(12):eabf1380
DOI: 10.1126/sciadv.abf1380 | PUBMED: 33731353 | IF(2018) = 12.5
PDB [P14]: 7A42 7A44

397: Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.
Sutherland M, Li A, Kaghad A, Panagopoulos D, Li F, Szewczyk M, Smil D, Scholten C, Bouché L, Stellfeld T, Arrowsmith CH, Barsyte D, Vedadi M, Hartung IV, Steuber H, Britton R, Santhakumar V.
ChemMedChem. (2021 Apr)16:1116-1125
DOI: 10.1002/cmdc.202100018 | PUBMED: 33513288 | IF(2018) = 3.0
PDB [P13]: 7NR4

396: Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII.
Smirnovienė J, Smirnov A, Zakšauskas A, Zubrienė A, Petrauskas V, Mickevičiūtė A, Michailovienė V, Čapkauskaitė E, Manakova E, Gražulis S, Baranauskienė L, Chen WY, Ladbury JE, Matulis D.
ChemistryOpen (2021 May)10:567-580
DOI: 10.1002/open.202100042 | PUBMED: 33945229
PDB [P13]: 6YH6 6YH8 6YHB 6YH5 6YH7 6YH9 6YHA 6YH4 6YHC

395: Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors.
Bauder M, Meyners C, Purder PL, Merz S, Sugiarto WO, Voll AM, Heymann T, Hausch F.
J Med Chem. (2021 Mar)64:3320-3349
DOI: 10.1021/acs.jmedchem.0c02195 | PUBMED: 33666419 | IF(2018) = 6.1
PDB [P13]: 7B9Z 7B9Y 7BA0

394: Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A.
J Med Chem. (2021 Apr)64:4623-4661
DOI: 10.1021/acs.jmedchem.0c02094 | PUBMED: 33818106 | IF(2018) = 6.1
PDB [P13P14]: 6ZF4 6ZF5 6ZF7 6ZF0 6ZF1 6ZF2 6ZF3 6ZF6

393: Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism.
Bustad HJ, Kallio JP, Laitaoja M, Toska K, Kursula I, Martinez A, Jänis J.
iScience. (2021 Mar)24:102152
DOI: 10.1016/j.isci.2021.102152 | PUBMED: 33665570 | IF(2020) = 4
PDB [P13P14]: 7AAJ 7AAK

392: Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Pannecoucke E, Van Trimpont M, Desmet J, Pieters T, Reunes L, Demoen L, Vuylsteke M, Loverix S, Vandenbroucke K, Alard P, Henderikx P, Deroo S, Baatz F, Lorent E, Thiolloy S, Somers K, McGrath Y, Van Vlierberghe P, Lasters I, Savvides SN.
Sci Adv. (2021 Mar)7:pp. UNK
DOI: 10.1126/sciadv.abe1682 | PUBMED: 33771865 | IF(2018) = 12.5
PDB [P14]: 6ZL1

391: Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP.
Shaikhqasem A, Schmitt K, Valerius O, Ficner R.
Acta Crystallogr F Struct Biol Commun. (2021 Mar)77:70-78
DOI: 10.1107/s2053230x2100203x | PUBMED: 33682791 | IF(2019) = 0.97
PDB [P13]: 7B51

390: Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1.
Ruegenberg S, Mayr FAMC, Atanassov I, Baumann U, Denzel MS.
Nat Commun. (2021 Apr)12:2176
DOI: 10.1038/s41467-021-22320-y | PUBMED: 33846315 | IF(2022) = 14.9
PDB [P13]: 6ZMK 7NDL

389: Structural insights into the inhibition of glycine reuptake.
Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR, Dawson RJP, Nissen P.
Nature (2021 Mar)591:677-681
DOI: 10.1038/s41586-021-03274-z | PUBMED: 33658720 | IF(2018) = 43.1
PDB [P14]: 6ZPL 6ZBV

388: The structure of Prp2 bound to RNA and ADP-BeF₃^- reveals structural features important for RNA unwinding by DEAH-box ATPases.
Hamann F, Zimmerningkat LC, Becker RA, Garbers TB, Neumann P, Hub JS, Ficner R.
Acta Crystallogr D Struct Biol. (2021 Apr)77:496-509
DOI: 10.1107/s2059798321001194 | PUBMED: 33825710 | IF(2018) = 3.2
PDB [P14]: 6ZM2

387: Arresting the Catalytic Arginine in Chlorite Dismutases: Impact on Heme Coordination, Thermal Stability, and Catalysis.
Schmidt D, Serra I, Mlynek G, Pfanzagl V, Hofbauer S, Furtmüller PG, Djinović-Carugo K, Van Doorslaer S, Obinger C.
Biochemistry (2021 Mar) 60:621-634
DOI: 10.1021/acs.biochem.0c00910 | PUBMED: 33586945 | IF(2018) = 3.0
PDB [P13]: 7ASB 7ATI

386: Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue.
Arkhipova V, Fu H, Hoorens MWH, Trinco G, Lameijer LN, Marin E, Feringa BL, Poelarends GJ, Szymanski W, Slotboom DJ, Guskov A.
J Am Chem Soc. (2021 Jan)143:1513-1520
DOI: 10.1021/jacs.0c11336 | PUBMED: 33449695 | IF(2018) = 14.7
PDB [P13]: 6ZLH 6ZGB 6ZL4

385: Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production.
Venskutonytė R, Koh A, Stenström O, Khan MT, Lundqvist A, Akke M, Bäckhed F, Lindkvist-Petersson K.
Nat Commun. (2021 Mar)12:1347
DOI: 10.1038/s41467-021-21548-y | PUBMED: 33649331 | IF(2022) = 14.9
PDB [P13]: 6T85

384: Structural basis of Naa20 activity towards a canonical NatB substrate.
Layer D, Kopp J, Fontanillo M, Köhn M, Lapouge K, Sinning I.
Commun Biol. 2021 Jan 4;4(1):2.
DOI: 10.1038/s42003-020-01546-4. | PUBMED: 33398031 | IF(2019) = 12.1
PDB [P14]: 6ZMP

383: Structural properties and peptide ligand binding of the capsid homology domains of human Arc.
Hallin EI, Bramham CR, Kursula P.
Biochem Biophys Rep. (2021 Jul)26:100975
DOI: 10.1016/j.bbrep.2021.100975 | PUBMED: 33732907
PDB [P13P14]: 6TQ0 6TNO 6TN7 6TNQ

382: The amphibian antimicrobial peptide uperin 3.5 is a cross-α/cross-β chameleon functional amyloid
Salinas N, Tayeb-Fligelman E, Sammito MD, Bloch D, Jelinek R, Noy D, Usón I, Landau M
Proc Natl Acad Sci U S A. 118(3):e2014442118.
DOI: 10.1073/pnas.2014442118 | PUBMED: 33431675 | IF(2019) = 9.4
PDB [P14]:

Number of publications for 2021: 99

2020

381: The copper(II)-binding tripeptide GHK, a valuable crystallization and phasing tag for macromolecular crystallography.
Mehr A, Henneberg F, Chari A, Görlich D, Huyton T.
Acta Crystallogr D Struct Biol. 2020 Dec 1;76(Pt 12):1222-1232.
DOI: 10.1107/S2059798320013741. | PUBMED: 33263328 | IF(2018) = 3.2
PDB [P14]:

380: RIM-binding protein couples synaptic vesicle recruitment to release sites.
Petzoldt AG, Götz TWB, Driller JH, Lützkendorf J, Reddy-Alla S, Matkovic-Rachid T, Liu S, Knoche E, Mertel S, Ugorets V, Lehmann M, Ramesh N, Beuschel CB, Kuropka B, Freund C, Stelzl U, Loll B, Liu F, Wahl MC, Sigrist SJ.
J Cell Biol. 2020 Jul 6;219(7):e201902059.
DOI: 10.1083/jcb.201902059. | PUBMED: 32369542 | IF(2018) = 8.8
PDB [P14]:

379: Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation.
Kisiala M, Kowalska M, Pastor M, Korza HJ, Czapinska H, Bochtler M.
Nucleic Acids Res. 2020 Jul 9;48(12):6954-6969.
DOI: 10.1093/nar/gkaa403. | PUBMED: 32459314 | IF(2018) = 11.1
PDB [P13]: 6G3B

378: C60 in a peptidic cage: a case of symmetry mismatch studied by crystallography and solid-state NMR.
Gilski M, Bernatowicz P, Sakowicz A, Szymański MP, Zalewska A, Szumna A, Jaskólski M
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2020 Oct 1;76(Pt 5):815-824.
DOI: 10.1107/S2052520620009944. | PUBMED: 33017315
PDB [P13]:

377: Aromatic Foldamer Helices as α-Helix Extended Surface Mimetics.
Zwillinger M, Reddy PS, Wicher B, Mandal PK, Csékei M, Fischer L, Kotschy A, Huc I.
Chemistry. 2020 Dec 23;26(72):17366-17370.
DOI: 10.1002/chem.202004064. Epub 2020 Nov 30. | PUBMED: 32910480 | IF(2019) = 4.9
PDB [P13]:

376: Serial synchrotron crystallography for time-resolved structural biology.
Pearson AR, Mehrabi P.
Curr Opin Struct Biol. 2020 Dec;65:168-174.
DOI: 10.1016/j.sbi.2020.06.019. | PUBMED: 32846363.
PDB [P14]:

375: The HARE chip for efficient time-resolved serial synchrotron crystallography.
Mehrabi P, Müller-Werkmeister HM, Leimkohl JP, Schikora H, Ninkovic J, Krivokuca S, Andriček L, Epp SW, Sherrell D, Owen RL, Pearson AR, Tellkamp F, Schulz EC, Miller RJD.
J Synchrotron Radiat. 2020 Mar 1;27(Pt 2):360-370.
DOI: 10.1107/S1600577520000685. | PUBMED: 32153274
PDB [P14]:

374: Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif.
Eriksen MS, Nikolaienko O, Hallin EI, Grødem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuéllar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR.
FEBS J. (2020 Nov)UNK:pp. UNK
DOI: 10.1111/febs.15618 | PUBMED: 33175445 | IF(2018) = 4.7
PDB [P13]: 6YTU

373: Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I.
Cell Chem Biol. (2020 Nov)27:1441-1451.e7
DOI: 10.1016/j.chembiol.2020.07.010 | PUBMED: 32726587
PDB [P13]: 6YEK

372: Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7.
Hanke S, Tindall CA, Pippel J, Ulbricht D, Pirotte B, Reboud-Ravaux M, Heiker JT, Sträter N.
J Med Chem. 2020 Jun 11;63(11):5723-5733.
DOI: 10.1021/acs.jmedchem.9b01806 | PUBMED: 32374603 | IF(2018) = 6.1
PDB [P14]:

371: Development of PSMA-1007-Related Series of 18F-Labeled Glu-Ureido-Type PSMA Inhibitors.
Cardinale J, Roscher M, Schäfer M, Geerlings M, Benešová Bauder-Wüst U, Remde Y, Eder M, Nováková Z, Motlová L, Barinka C, Giesel FL, Kopka K.
J Med Chem. 2020 Oct 8;63(19):10897-10907.
DOI: 10.1021/acs.jmedchem.9b01479 | PUBMED: 32852205 | IF(2018) = 6.1
PDB [P13]: 5O5T

370: Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Weidenhausen J, Kopp J, Armbruster L, Wirtz M, Lapouge K, Sinning I.
NAT: DE
DOI: 10.1016/j.str.2020.12.004 | PUBMED: 33400917
PDB [P13]: 6Z00

369: High-resolution structural insights into the heliorhodopsin family.
Kovalev K, Volkov D, Astashkin R, Alekseev A, Gushchin I, Haro-Moreno JM, Chizhov I, Siletsky S, Mamedov M, Rogachev A, Balandin T, Borshchevskiy V, Popov A, Bourenkov G, Bamberg E, Rodriguez-Valera F, Büldt G, Gordeliy V.
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4131-4141.
DOI: 10.1073/pnas.1915888117 | PUBMED: 32034096 | IF(2019) = 9.4
PDB [P14]:

368: Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.
Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C.
Nat Commun. 2020 Jan 23;11(1):440.
DOI: 10.1038/s41467-020-14343-8 | PUBMED: 31974402 | IF(2022) = 14.9
PDB [P14]:

367: Ctf18-RFC and DNA Pol ϵ form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication.
Stokes K, Winczura A, Song B, Piccoli G, Grabarczyk DB.
NAT: UK, DE
DOI: 10.1093/nar/gkaa541 | PUBMED: 32585006
PDB [P13]: 6S1C

366: A Proline-Rich Element in the Type III Secretion Protein FlhB Contributes to Flagellar Biogenesis in the Beta- and Gamma-Proteobacteria.
Hook JC, Blagotinsek V, Pané-Farré J, Mrusek D, Altegoer F, Dornes A, Schwan M, Schier L, Thormann KM, Bange G.
Front Microbiol. (2020 )11:564161
DOI: 10.3389/fmicb.2020.564161 | PUBMED: 33384667 | IF(2019) = 4.2
PDB [P13]: 6Z0W

365: Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P_i Release.
Franz P, Ewert W, Preller M, Tsiavaliaris G.
Int J Mol Sci. (2020 Dec) 22:104
DOI: 10.3390/ijms22010104 | PUBMED: 33374308 | IF(2018) = 4.2
PDB [P13]: 7B1A

364: The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action.
Weikum J, Kulakova A, Tesei G, Yoshimoto S, Jægerum LV, Schütz M, Hori K, Skepö M, Harris P, Leo Morth JP
Sci Rep. 2020 Dec 4;10(1):21249.
DOI: 10.1038/s41598-020-77706-7 | PUBMED: 33277518 | IF(2018) = 4.1
PDB [P14]: 6TQD 6TPL

363: HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation.
Songailiene I, Juozapaitis J, Tamulaitiene G, Ruksenaite A, Šulčius S, Sasnauskas G, Venclovas Č, Siksnys V.
Mol Cell. (2020 Dec)80:955-970.e7
DOI: 10.1016/j.molcel.2020.11.034 | PUBMED: 33290744 | IF(2018) = 14.5
PDB [P13]: 7AE6 7AE8 7AE9 7AE2

362: Diamond refractive micro-lenses for full-field X-ray imaging and microscopy produced with ion beam lithography.
Medvedskaya, P., Lyatun, I., Shevyrtalov, S., Polikarpov, M., Snigireva, I., Yunkin, V., & Snigirev, A.
Optics express. 28(4), 4773-S785.
DOI: 10.1364/OE.384647 | PUBMED: 32121709 | IF(2019) = 3.67
PDB [P14]:

361: Crystal structures of a novel family IV esterase in free and substrate-bound form.
Höppner A, Bollinger A, Kobus S, Thies S, Coscolín C, Ferrer M, Jaeger KE, Smits SHJ.
FEBS J. (2020 Dec) UNK:pp. UNK
DOI: 10.1111/febs.15680 | PUBMED: 33342083 | IF(2018) = 4.7
PDB [P14]: 6Z68

360: Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis.
Kozak S, Bloch Y, De Munck S, Mikula A, Bento I, Savvides SN, Meijers R.
NAT: BEL, DE
DOI: 10.1107/s2059798320013753 | PUBMED: 33263330
PDB [P13]: 6ZR7 6SFF

359: Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.
Myllykoski M, Sutinen A, Koski MK, Kallio JP, Raasakka A, Myllyharju J, Wierenga RK, Koivunen P.
J Biol Chem. (2020 Dec)UNK:pp. UNK
DOI: 10.1074/jbc.ra120.016542 | PUBMED: 33334883 | IF(2018) = 4.1
PDB [P13]: 6TP5

358: Inhibition of urease, a Ni-enzyme: the reactivity of a key thiol with mono- and di-substituted catechols elucidated by kinetic, structural and theoretical studies.
Mazzei L, Contaldo U, Musiani F, Cianci M, Bagnolini G, Roberti M, Ciurli S.
Angew Chem Int Ed Engl. (2020 Nov)UNK:pp. UNK
DOI: 10.1002/anie.202014706 | PUBMED: 33245574 | IF(2019) = 13.0
PDB [P13]: 6ZNY 6ZNZ 6ZO1

357: Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
Chaikuad A, Pollinger J, Rühl M, Ni X, Kilu W, Heering J, Merk D.
Int J Mol Sci (2020 Nov)21:pp. UNK
DOI: 10.3390/ijms21228457 | PUBMED: 33187070
PDB [P13]: 7A77

356: Structural and functional characterization of the glutathione peroxidase-like thioredoxin peroxidase from the fungus Trichoderma reesei.
Adriani PP, de Paiva FCR, de Oliveira GS, Leite AC, Sanches AS, Lopes AR, Dias MVB, Chambergo FS.
Int J Biol Macromol (2020 Nov)167:93-100
DOI: 10.1016/j.ijbiomac.2020.11.179 | PUBMED: 33259843
PDB [P13]: 6VPD

355: Phi class glutathione transferases as molecular targets towards multiple-herbicide resistance: Inhibition analysis and pharmacophore design.
Georgakis N, Poudel N, Vlachakis D, Papageorgiou AC, Labrou NE.
Plant Physiol Biochem. (2020 Nov)UNK:pp. UNK
DOI: 10.1016/j.plaphy.2020.11.018 | PUBMED: 33257232 | IF(2019) = 3.72
PDB [P14]: 6ZB6

354: Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B.
J Med Chem. (2020 Nov)63:13709-13718
DOI: 10.1021/acs.jmedchem.0c01202 | PUBMED: 33143415 | IF(2018) = 6.1
PDB [P13]: 6ZFM

353: Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection.
Anjanappa R, Garcia-Alai M, Kopicki JD, Lockhauserbäumer J, Aboelmagd M, Hinrichs J, Nemtanu IM, Uetrecht C, Zacharias M, Springer S, Meijers R.
Nat Commun. (2020 Mar)11:1314
DOI: 10.1038/s41467-020-14862-4 | PUBMED: 32161266 | IF(2022) = 14.9
PDB [P14]: 6TDP 6TDO 6TDQ 6TDS 6TDR

352: Exposing the distinctive modular behavior of β-strands and α-helices in folded proteins.
Wang H, Logan DT, Danielsson J, Oliveberg M.
Proc Natl Acad Sci U S A. (2020 Nov) 117:28775-28783
DOI: 10.1073/pnas.1920455117 | PUBMED: 33148805 | IF(2019) = 9.4
PDB [P14]: 6I6E 6I69 6I6I 6I6O

351: Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter.
Normant V, Josts I, Kuhn L, Perraud Q, Fritsch S, Hammann P, Mislin GLA, Tidow H, Schalk IJ.
ACS Chem Biol. (2020 Oct)15:2741-2751
DOI: 10.1021/acschembio.0c00535 | PUBMED: 32902248 | IF(2019) = 4.43
PDB [P14]: 6Z8A

350: Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode.
Drakou CE, Gardeli C, Tsialtas I, Alexopoulos S, Mallouchos A, Koulas SM, Tsagkarakou AS, Asimakopoulos D, Leonidas DD, Psarra AG, Skamnaki VT.
J Agric Food Chem (2020 Sep)68:10191-10199
DOI: 10.1021/acs.jafc.0c04205 | PUBMED: 32840370
PDB [P13]: 6YVE

349: Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Kirsch K, Zeke A, Tőke O, Sok P, Sethi A, Sebő A, Kumar GS, Egri P, Póti ÁL, Gooley P, Peti W, Bento I, Alexa A, Reményi A.
Nat Commun. (2020 Nov)11:5769
DOI: 10.1038/s41467-020-19582-3 | PUBMED: 33188182 | IF(2022) = 14.9
PDB [P14]: 6ZQS 6ZR5

348: A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
Stefano JE, Lord DM, Zhou Y, Jaworski J, Hopke J, Travaline T, Zhang N, Wong K, Lennon A, He T, Bric-Furlong E, Cherrie C, Magnay T, Remy E, Brondyk W, Qiu H, Radošević K.
J Biol Chem. (2020 Oct)UNK:pp. UNK
DOI: 10.1074/jbc.ra120.012395 | PUBMED: 33122192 | IF(2018) = 4.1
PDB [P14]: 6VC9

347: Gas channel rerouting in a primordial enzyme: Structural insights of the carbon-monoxide dehydrogenase/acetyl-CoA synthase complex from the acetogen Clostridium autoethanogenum.
Lemaire ON, Wagner T.
Biochim Biophys Acta Bioenerg. (2020 Oct)1862:148330
DOI: 10.1016/j.bbabio.2020.148330 | PUBMED: 33080205
PDB [P13]: 6YTT

346: Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.
Liess AKL, Kucerova A, Schweimer K, Schlesinger D, Dybkov O, Urlaub H, Mansfeld J, Lorenz S.
Sci Signal. (2020 Oct)13:pp. UNK
DOI: 10.1126/scisignal.aba8208 | PUBMED: 33082289 | IF(2019) = 4.9
PDB [P13]: 6S96

345: Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System.
Bertelsen MB, Senissar M, Nielsen MH, Bisiak F, Cunha MV, Molinaro AL, Daines DA, Brodersen DE.
Structure. (2020 Oct)UNK:pp. UNK
DOI: 10.1016/j.str.2020.10.002 | PUBMED: 33096014 | IF(2018) = 4.9
PDB [P13]: 6ZI0 6ZI1

344: Structural role of essential light chains in the apicomplexan glideosome.
Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Löw C.
Commun Biol. (2020 Oct)3:568
DOI: 10.1038/s42003-020-01283-8 | PUBMED: 33051581 | IF(2019) = 12.1
PDB [P13]: 6ZN3 6TJ4 6TJ5 6TJ6 6TJ7

343: Structural basis for inhibition of an archaeal CRISPR-Cas type I-D large subunit by an anti-CRISPR protein.
Manav MC, Van LB, Lin J, Fuglsang A, Peng X, Brodersen DE.
Nat Commun. (2020 Nov)11:5993
DOI: 10.1038/s41467-020-19847-x | PUBMED: 33239638 | IF(2022) = 14.9
PDB [P14]: 6THH

342: Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions.
Michailidou F, Klöcker N, Cornelissen N, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A.
Angew Chem Int Ed Engl. (2020 Oct)UNK:pp. UNK
DOI: 10.1002/anie.202012623 | PUBMED: 33017502 | IF(2019) = 13.0
PDB [P13]: 6LTV 6LTW

341: Rational design of balanced dual-targeting antibiotics with limited resistance.
Nyerges A, Tomaš T, Durcik M, Revesz T, Szili P, Draskovits G, Bogar F, Skok Ž, Zidar N, Ilaš J, Zega A, Kikelj D, Daruka L, Kintses B, Vasarhelyi B, Foldesi I, Kata D, Welin M, Kimbung R, Focht D, Mašič LP, Pal C.
PLoS Biol. 2020 Oct 5;18(10):e3000819.
DOI: 10.1371/journal.pbio.3000819. | PUBMED: 33017402 | IF(2018) = 8.4
PDB [P13]: 6TCK

340: Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle.
Dudutiene V, Zubriene A, Kairys V, Smirnov A, Smirnovien J, Leitans J, Kazaks A, Tars K, Manakova L, Gražulis S, Matulis D.
Biophys J (2020 Sep)UNK:pp. UNK
DOI: 10.1016/j.bpj.2020.08.037 | PUBMED: 32971003
PDB [P14]: 6T4N 6T4O 6T81 6T5Q 6T5P 6T5C

339: High-resolution crystal structure and biochemical characterization of a GH11 endoxylanase from Nectria haematococca.
Andaleeb H, Ullah N, Falke S, Perbandt M, Brognaro H, Betzel C.
Sci Rep. (2020 Sep)10:15658
DOI: 10.1038/s41598-020-72644-w | PUBMED: 32973265 | IF(2018) = 4.1
PDB [P13]: 6Y0H

338: Anomeric Selectivity of Trehalose Transferase with Rare l-Sugars.
Mestrom L, Marsden SR, van der Eijk H, Laustsen JU, Jeffries CM, Svergun DI, Hagedoorn PL, Bento I, Hanefeld U.
ACS Catalysis. (2020 Aug)10:8835-8839
DOI: 10.1021/acscatal.0c02117 | PUBMED: 32953231 | IF(2018) = 12.1
PDB [P13]: 6ZJ4 6ZJ7 6ZMZ 6ZJH 6ZN1

337: Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.
Mokrushina YA, Golovin AV, Smirnov IV, Chatziefthimiou SD, Stepanova AV, Bobik TV, Zalevsky AO, Zlobin AS, Konovalov KA, Terekhov SS, Stepanov AV, Pipiya SO, Shamborant OG, Round E, Belogurov AA, Bourenkov G, Makarov AA, Wilmanns M, Xie J, Blackburn GM, Gabibov AG, Lerner RA.
Proc Natl Acad Sci U S A. (2020 Aug) UNK:pp. UNK
DOI: 10.1073/pnas.2010317117 | PUBMED: 32859757 | IF(2019) = 9.4
PDB [P14]: 6Y49 6Y1M 6Y1K 6Y1L

336: Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions.
Stalmans G, Lilina AV, Vermeire PJ, Fiala J, Novák P, Strelkov SV.
Cells. (2020 Jul) 9:pp. UNK
DOI: 10.3390/cells9071633 | PUBMED: 32645958 | IF(2019) = 4.4
PDB [-P14]: 6YSH

335: Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A.
Fiebig T, Cramer JT, Bethe A, Baruch P, Curth U, Führing JI, Buettner FFR, Vogel U, Schubert M, Fedorov R, Mühlenhoff M.
Nat Commun. (2020 Sep)11:4723
DOI: 10.1038/s41467-020-18464-y | PUBMED: 32948778 | IF(2022) = 14.9
PDB [P14]: 6YUS 6YUQ

334: Structural and Functional Characterization of NadR from Lactococcus lactis.
Stetsenko A, Singh R, Jaehme M, Guskov A, Slotboom DJ.
Molecules. (2020 Apr) 25:pp. UNK
DOI: 10.3390/molecules25081940 | PUBMED: 32331317 | IF(2020) = 3.3
PDB [P13]: 6GYF 6GZO

333: Structural and biochemical characterization of a family 7 highly thermostable endoglucanase from the fungus Rasamsonia emersonii.
Schiano-di-Cola C, Kołaczkowski B, Sørensen TH, Christensen SJ, Cavaleiro AM, Windahl MS, Borch K, Morth JP, Westh P.
FEBS J. (2020 Jun) 287:2577-2596
DOI: 10.1111/febs.15151 | PUBMED: 31755197 | IF(2018) = 4.7
PDB [P14]: 6SU8

332: Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S.
J Med Chem. (2020 Jul) 63:6784-6801
DOI: 10.1021/acs.jmedchem.9b01803 | PUBMED: 32433887 | IF(2018) = 6.1
PDB [P13]: 6T29

331: Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis.
Meyer T, Zumbrägel N, Geerds C, Gröger H, Niemann HH.
Biomolecules (2020 Jul) 10:pp. UNK
DOI: OI: 10.3390/biom10081130 | PUBMED: 32751900 | IF(2019) = 4.7
PDB [P13]: 6SMT

330: The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure.
Engelberg Y, Landau M
Nat Commun. (2020 Aug 4) 11(1):3894.
DOI: 10.1038/s41467-020-17736-x | PUBMED: 32753597 | IF(2022) = 14.9
PDB [P14]: 6S6M

329: Sjogren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells.
Perdreau-Dahl H, Progida C, Barfeld SJ, Guldsten H, Thiede B, Arntzen M, Bakke O, Mills IG, Krauss S, Morth JP
Commun Biol. (2020 Mar 13) 3(1):123.
DOI: 10.1038/s42003-020-0851-2 | PUBMED: 32170109 | IF(2019) = 12.1
PDB [P13]: 6HCZ

328: Molecular mechanism of light-driven sodium pumping.
Kovalev K, Astashkin R, Gushchin I, Orekhov P, Volkov D, Zinovev E, Marin E, Rulev M, Alekseev A, Royant A, Carpentier P, Vaganova S, Zabelskii D, Baeken C, Sergeev I, Balandin T, Bourenkov G, Carpena X, Boer R, Maliar N, Borshchevskiy V, Buldt G, Bamberg E, Gordeliy V
Nat Commun. (2020 May 1) 11(1):2137.
DOI: 10.1038/s41467-020-16032-y | PUBMED: 32358514 | IF(2022) = 14.9
PDB [P14]: 6YC2 6YC3 6YC4

327: Structure-based design approach to rational site-directed mutagenesis ofbeta-lactoglobulin.
Bonarek P, Loch JI, Tworzydlo M, Cooper DR, Milto K, Wrobel P, Kurpiewska K, Lewinski K
J Struct Biol. (2020 May 1) 210(2):107493.
DOI: 10.1016/j.jsb.2020.107493 | PUBMED: 32169624 | IF(2018) = 3.8
PDB [P13]: 6RYT

326: Structural Studies of Glutamate Dehydrogenase (Isoform 1) From Arabidopsisthaliana, an Important Enzyme at the Branch-Point Between Carbon and NitrogenMetabolism.
Grzechwiak M, Sliwiak J, Jaskolski M, Ruszkowski M
Front Plant Sci. 2020 Jun 5;11:754.
DOI: 10.3389/fpls.2020.00754 | PUBMED: 32655590 | IF(2016) = 4.4
PDB [P13]: 6YEI 6YEH

325: Architecture and functional dynamics of the pentafunctional AROM complex.
Arora Veraszto H, Logotheti M, Albrecht R, Leitner A, Zhu H, Hartmann MD,
Nat Chem Biol. 2020 Jul 6.
DOI: 10.1038/s41589-020-0587-9 | PUBMED: 32632294 | IF(2020) = 41.8
PDB [P14]: 6HQV

324: Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.
Grabarczyk DB,
Nucleic Acids Res. 2020 Jul 9;48(12):6996-7004.
DOI: 10.1093/nar/gkaa456 | PUBMED: 32469068 | IF(2018) = 11.1
PDB [P14]: 6XWX

323: Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA.
Szewczyk M, Malik D, Borowski LS, Czarnomska SD, Kotrys AV, Klosowska-Kosicka K, Nowotny M, Szczesny RJ,
Nucleic Acids Res. 2020 Jun 4;48(10):5572-5590.
DOI: 10.1093/nar/gkaa302 | PUBMED: 32365187 | IF(2018) = 11.1
PDB [P13]: 6STY

322: Structural basis for antibiotic action of the B1 antivitamin 2'-methoxy-thiamine.
Rabe von Pappenheim F, Aldeghi M, Shome B, Begley T, de Groot BL, Tittmann K.
Nat Chem Biol. (2020 Aug) UNK:pp. UNK
DOI: 10.1038/s41589-020-0628-4 | PUBMED: 32839604 | IF(2020) = 41.8
PDB [P14]: 6TJ8 6TJ9

321: Structural signatures in EPR3 define a unique class of plant carbohydrate receptors.
Wong JEMM, Gysel K, Birkefeldt TG, Vinther M, Muszyński A, Azadi P, Laursen NS, Sullivan JT, Ronson CW, Stougaard J, Andersen KR.
Nat Commun. (2020 Jul)11:3797
DOI: 10.1038/s41467-020-17568-9 | PUBMED: 32732998 | IF(2022) = 14.9
PDB [P14]: 6QUP

320: Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System.
Laursen NS, Pedersen DV, Gytz H, Zarantonello A, Bernth Jensen JM, Hansen AG, Thiel S, Andersen GR.
Front Immunol. (2020 )11:1504
DOI: 10.3389/fimmu.2020.01504 | PUBMED: 32849513 | IF(2018) = 6.4
PDB [P14]: 6Z6V

319: A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Picado A, Chaikuad A, Wells CI, Shrestha S, Zuercher WJ, Pickett JE, Kwarcinski FE, Sinha P, de Silva CS, Zutshi R, Liu S, Kannan N, Knapp S, Drewry DH, Willson TM.
J Med Chem. (2020 Dec)63:14626-14646
DOI: 10.1021/acs.jmedchem.0c01174 | PUBMED: 33215924 | IF(2018) = 6.1
PDB [P13]: 6ZJF

318: An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
Zarantonello A, Presumey J, Simoni L, Yalcin E, Fox R, Hansen A, Olesen HG, Thiel S, Johnson MB, Stevens B, Laursen NS, Carroll MC, Andersen GR.
J Immunol. (2020 Aug)UNK:pp. UNK
DOI: 10.4049/jimmunol.2000528 | PUBMED: 32769120 | IF(2019) = 4.7
PDB [P13]: 6YSQ

317: Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine.
Malik D, Kobyłecki K, Krawczyk P, Poznański J, Jakielaszek A, Napiórkowska A, Dziembowski A, Tomecki R, Nowotny M.
Nucleic Acids Res. (2020 Aug)UNK:pp. UNK
DOI: 10.1093/nar/gkaa647 | PUBMED: 32785623 | IF(2018) = 11.1
PDB [P13]: 6YWN 6YWO

316: Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1.
Shaikhqasem A, Dickmanns A, Neumann P, Ficner R.
J Med Chem. 2020 Jul 7545-7558
DOI: DOI: 10.1021/acs.jmedchem.0c00143 | PUBMED: 32585100 | IF(2018) = 6.1
PDB [P14]: 6TVO

315: MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Sok P, Gógl G, Kumar GS, Alexa A, Singh N, Kirsch K, Sebő A, Drahos L, Gáspári Z, Peti W, Reményi A.
Structure (2020 Jul) pp. UNK
DOI: DOI: 10.1016/j.str.2020.06.007 | PUBMED: 32649858 | IF(2018) = 4.9
PDB [P14]: 6TCA

314: Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2.
Lindenblatt D, Nickelsen A, Applegate VM, Jose J, Niefind K.
J Med Chem. 2020 Jul7766-7772
DOI: DOI: 10.1021/acs.jmedchem.0c00587 | PUBMED: 32589844 | IF(2018) = 6.1
PDB [P13]: 6TEW 6TEI

313: Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
Mpakali A, Saridakis E, Giastas P, Maben Z, Stern LJ, Larhed M, Hallberg M, Stratikos E.
ACS Med Chem Lett. 2020 Jul1429-1434
DOI: DOI: 10.1021/acsmedchemlett.0c00172 | PUBMED: 32676150 | IF(2018) = 3.7
PDB [P13]: 6YDX

312: Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.
Kupski O, Funk LM, Sautner V, Seifert F, Worbs B, Ramsbeck D, Meyer F, Diederichsen U, Buchholz M, Schilling S, Demuth HU, Tittmann K.
Biochemistry. 2020 Jul2585-2591
DOI: DOI: 10.1021/acs.biochem.0c00337 | PUBMED: 32551535 | IF(2018) = 3.0
PDB [P13]: 6YI1 6YJY

311: Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences.
Jolma A, Zhang J, Mondragón E, Morgunova E, Kivioja T, Laverty KU, Yin Y, Zhu F, Bourenkov G, Morris Q, Hughes TR, Maher LJ, Taipale J.
Genome Res. 2020 Julpp. UNK
DOI: DOI: 10.1101/gr.258848.119 | PUBMED: 32703884 | IF(2019) = 9.9
PDB [P13]: 6SJD

310: Heptabladed β-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system.
Fujdiarová E, Houser J, Dobeš P, Paulíková G, Kondakov N, Kononov L, Hyršl P, Wimmerová M.
FEBS J. 2020 J npp. UNK
DOI: DOI: 10.1111/febs.15457 | PUBMED: 32559333 | IF(2018) = 4.7
PDB [P13]: 6RGG

309: A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding.
Terekhov SS, Mokrushina YA, Nazarov AS, Zlobin A, Zalevsky A, Bourenkov G, Golovin A, Belogurov A, Osterman IA, Kulikova AA, Mitkevich VA, Lou HJ, Turk BE, Wilmanns M, Smirnov IV, Altman S, Gabibov AG.
Sci Adv. 2020 6(26):eaaz9861
DOI: 10.1126/sciadv.aaz9861 | PUBMED: 32637600 | IF(2018) = 12.5
PDB [P13]: 6SUI 6SV5 6SUM 6SUL 6SUN

308: Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum.
Burda PC, Crosskey T, Lauk K, Zurborg A, Söhnchen C, Liffner B, Wilcke L, Pietsch E, Strauss J, Jeffries CM, Svergun DI, Wilson DW, Wilmanns M, Gilberger TW.
Cell Rep. 2020 Jun107817
DOI: 10.1016/j.celrep.2020.107817 | PUBMED: 32579913 | IF(2018) = 8.1
PDB [P13]: 6TLB

307: Crystal structures of native cytochrome c6 from Thermosynechococcus elongatus in two different space groups and implications for its oligomerization.
Falke S, Feiler C, Chapman H, Sarrou I.
Acta Crystallogr F Struct Biol Commun (2020 Sep)76:444-452
DOI: 10.1107/s2053230x20010249 | PUBMED: 32880593
PDB [P13]: 6TR1

306: Crystal and solution structures of fragments of the human leucocyte commonantigen-related protein.
Vilstrup J, Simonsen A, Birkefeldt T, Strandbygard D, Lyngso J, Pedersen JS, Thirup S,
Acta Crystallogr D Struct Biol. 2020 May 1;76(Pt 5):406-417.
DOI: 10.1107/S2059798320003885 | PUBMED: 32355037 | IF(2018) = 3.2
PDB [P14]: 6TPV

305: Molecular basis of MKLP2-dependent Aurora B transport from chromatin to theanaphase central spindle.
Serena M, Bastos RN, Elliott PR, Barr FA,
J Cell Biol. 2020 Jul 6;219(7).
DOI: 10.1083/JCB.201910059 | PUBMED: 32356865 | IF(2018) = 8.8
PDB [P14]: 6YIE

304: High-resolution crystal structures of a "half sandwich"-type Ru(II) coordination compound bound to hen egg-white lysozyme and proteinase K.
Chiniadis L, Bratsos I, Bethanis K, Karpusas M, Giastas P, Papakyriakou A,
J Biol Inorg Chem. 2020 Apr 8.
DOI: 10.1007/S00775-020-01786-Z | PUBMED: 32266561 | IF(2018) = 3.6
PDB [P13]: 6TXG

303: Crossing the Border: From Keto- to Imine Reduction in Short-ChainDehydrogenases/Reductases.
Muller M, Roth S, Stockinger P, Steff J, Steimle S, Sautner V, Tittmann K, Pleiss J,
ChemBioChem. 2020 Apr 21.
DOI: 10.1002/CBIC.202000233 | PUBMED: 32315494 | IF(2018) = 2.6
PDB [P14]: 6Y4D

302: Structural and functional characterization of the severe fever withthrombocytopenia syndrome virus L protein.
Vogel D, Thorkelsson SR, Quemin ERJ, Meier K, Kouba T, Gogrefe N, Busch C, Reindl S, Gunther S, Cusack S, Grunewald K, Rosenthal M
Nucleic Acids Res. 2020 Jun 4;48(10):5749-5765.
DOI: 10.1093/nar/gkaa253 | PUBMED: 32313945 | IF(2018) = 11.1
PDB [P14]: 6XYA

301: Flexible loops of New Delhi metallo-beta-lactamase modulate its activity towards different substrates.
Raczynska JE, Imiolczyk B, Komorowska M, Sliwiak J, Czyrko-Horczak J, Brzezinski K, Jaskolski M,
Int J Biol Macromol. 2020 Apr 28;158:104-115.
DOI: 10.1016/J.IJBIOMAC.2020.04.219 | PUBMED: 32353499 | IF(2018) = 4.8
PDB [P13]: 6TWT

300: Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding:Hint on Differences in Selectivity Determinants of Both Proteins?
Ngo K, Collins-Kautz C, Gerstenecker S, Wagner B, Heine A, Klebe G,
J Med Chem. 2020 Mar 26;63(6):3274-3289.
DOI: 10.1021/ACS.JMEDCHEM.9B02061 | PUBMED: 32011145 | IF(2018) = 6.1
PDB [P13]: 6T0M 6T0P

299: Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Singh K, Graf B, Linden A, Sautner V, Urlaub H, Tittmann K, Stark H, Chari A
Cell. 2020 Mar 19;180(6):1130-1143.e20.
DOI: 10.1016/j.cell.2020.02.034 | PUBMED: 32160528 | IF(2018) = 36.2
PDB [P14]: 6QL9 6QL7

298: A Proof-of-Concept Fragment Screening of a Hit-Validated 96-Compounds Libraryagainst Human Carbonic Anhydrase II.
Glockner S, Heine A, Klebe G
Biomolecules. 2020 Mar 29;10(4).
DOI: 10.3390/BIOM10040518 | PUBMED: 32235320 | IF(2019) = 4.7
PDB [P13]: 6S9Z 6RMP 5M78

297: Halogenated and di-substituted benzenesulfonamides as selective inhibitors ofcarbonic anhydrase isoforms.
Zaksauskas A, Capkauskaite E, Jezepcikas L, Linkuviene V, Paketuryte V, Smirnov A, Leitans J, Kazaks A, Dvinskis E, Manakova E, Grazulis S, Tars K, Matulis D,
Eur J Med Chem. 2020 Jan 1;185:111825.
DOI: 10.1016/J.EJMECH.2019.111825 | PUBMED: 31740053 | IF(2018) = 4.8
PDB [P14]: 6R6Y

296: Regioselectivity of hyoscyamine 6β-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations.
Kluza A, Wojdyla Z, Mrugala B, Kurpiewska K, Porebski PJ, Niedzialkowska E, Minor W, Weiss MS, Borowski T.
Dalton T. ( 2020 Apr ) 49 :4454-4469
DOI: 10.1039/d0dt00302f | PUBMED: 32182320 | IF(2018) = 4.1
PDB [P13]: 6TTM

295: Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture.
Gulen B, Rosselin M, Fauser J, Albers MF, Pett C, Krisp C, Pogenberg V, Schlüter H, Hedberg C, Itzen A.
Nat Chem. (2020 Aug)12:732-739
DOI: 10.1038/s41557-020-0484-6 | PUBMED: 32632184 | IF(2019) = 21.7
PDB [P13]: 6SIU

294: Loss of GFAT-1 feedback regulation activates the hexosamine pathway thatmodulates protein homeostasis.
Ruegenberg S, Horn M, Pichlo C, Allmeroth K, Baumann U, Denzel MS,
Nat Commun. 2020 Feb 4;11(1):687.
DOI: 10.1038/s41467-020-14524-5 | PUBMED: 32019926 | IF(2022) = 14.9
PDB [P13]: 6SVO

293: Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2.
Hamann F, Schmitt A, Favretto F, Hofele R, Neumann P, Xiang S, Urlaub H, Zweckstetter M, Ficner R,
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2948-2956.
DOI: 10.1073/pnas.1907960117 | PUBMED: 31974312 | IF(2019) = 9.4
PDB [P13]: 6R4E 6RM8 6RMC 6RMB 6RMA 6RM9

292: p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Gebel J, Tuppi M, Chaikuad A, Hotte K, Schroder M, Schulz L, Lohr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dotsch V,
Nat Chem Biol. 2020 Jul 27. pii: 10.1038/s41589-020-0600-3. doi:10.1038/s41589-020-0600-3.
DOI: 10.1038/s41589-020-0600-3 [doi] | PUBMED: 32719556 | IF(2020) = 41.8
PDB [P13]: 6RU6

291: Structure of a robust bacterial protein cage and its application as a versatile biocatalytic platform through enzyme encapsulation.
Lončar N, Rozeboom HJ, Franken LE, Stuart MCA, Fraaije MW.
Biochem Biophys Res Commun. (2020 Aug)529:548-553
DOI: 10.1016/j.bbrc.2020.06.059 | PUBMED: 32736672 | IF(2019) = 3.0
PDB [P13]: 6I9G

290: A Novel Polyester Hydrolase From the Marine Bacterium Pseudomonas aestusnigri - Structural and Functional Insights.
Bollinger A, Thies S, Knieps-Grünhagen E, Gertzen C, Kobus S, Höppner A, Ferrer M, Gohlke H, Smits SHJ, Jaeger .
Front Microbiol. (2020 )11:114
DOI: 10.3389/fmicb.2020.00114 | PUBMED: 32117139 | IF(2019) = 4.2
PDB [P13]: 6SCD

289: The structural basis of fungal glucuronoyl esterase activity on natural substrates.
Ernst HA, Mosbech C, Langkilde AE, Westh P, Meyer AS, Agger JW, Larsen S
Nat Commun. 2020 Feb 24;11(1):1026.
DOI: 10.1038/S41467-020-14833-9 | PUBMED: 32094331 | IF(2022) = 14.9
PDB [P13]: 6RU1

288: Triple-Helix-Stabilizing Effects in Collagen Model Peptides ContainingPPII-Helix-Preorganized Diproline Modules.
Maassen A, Gebauer JM, Theres Abraham E, Grimm I, Neudorfl JM, Kuhne R, Neundorf I, Baumann U, Schmalz HG,
ngew Chem Int Ed Engl. 2020 Jan 16.
DOI: 10.1002/ANIE.201914101 | PUBMED: 31944532
PDB [P13]: 6SYJ

287: Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
Lillebostad PAG, Raasakka A, Hjellbrekke SJ, Patil S, Røstbø T, Hollås H, Sakya SA, Szigetvari PD, Vedeler A, Kursula P.
Biomolecules (2020 Apr)10:pp. UNK
DOI: 10.3390/biom10040660 | PUBMED: 32344647 | IF(2019) = 4.7
PDB [P13]: 6TU2

Number of publications for 2020: 95

2019

286: The Impact of pH on Catalytically Critical Protein Conformational Changes: The Case of the Urease, a Nickel Enzyme.
Mazzei L, Cianci M, Benini S, Ciurli S
Chemistry. 2019 Sep 18;25(52):12145-12158.
DOI: 10.1002/CHEM.201902320 | PUBMED: 31271481 | IF(2019) = 4.9
PDB [P13]: 6RP1 6RKG

285: Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties.
Gagner VA, Lundholm I, Garcia-Bonete MJ, Rodilla H, Friedman R, Zhaunerchyk V, Bourenkov G, Schneider T, Stake J, Katona G,
Sci Rep. 2019 Dec 17;9(1):19281.
DOI: 10.1038/s41598-019-55777-5 | PUBMED: 31848402 | IF(2018) = 4.1
PDB [P14]: 6SW0 6SVG 6SVZ 6SVU 6SVW 6RIV 6SVX 6SVD 6SUX 6SVV 6SV9 6SV8 6SVB 6SV0 6SV6 6SVJ 6SVI 6SVN 6SVR

284: Identification and characterization of a novel chemotype for human TLR8 inhibitors.
Sribar D, Grabowski M, Murgueitio MS, Bermudez M, Weindl G, Wolber G,
Eur J Med Chem. 2019 Oct 1;179:744-752. Epub2019 Jun 29.
DOI: 10.1016/J.EJMECH.2019.06.084 | PUBMED: 31284084 | IF(2018) = 4.8
PDB [P14]: 6R6F

283: Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.
De Bortoli F, Neumann A, Kotte A, Timmermann B, Schuler T, Wahl MC, Loll B, Heyd F,
Nucleic Acids Res. 2019 Jun 20;47(11):5867-5879.
DOI: 10.1093/nar/gkz243 | PUBMED: 30949712 | IF(2018) = 11.1
PDB [P14]:

282: Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses.
Alvarez CE, Bovdilova A, Hoppner A, Wolff CC, Saigo M, Trajtenberg F, Zhang T, Buschiazzo A, Nagel-Steger L, Drincovich MF, Lercher MJ, Maurino VG,
Nat Plants. 2019 Jul;5(7):755-765. Epub 2019 Jun 24.
DOI: 10.1038/s41477-019-0451-7 | PUBMED: 31235877 | IF(2019) = 13.3
PDB [P13]:

281: Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target.
Schussler S, Haase I, Perbandt M, Illarionov B, Siemens A, Richter K, Bacher A, Fischer M, Grawert T,
Acta Crystallogr F Struct Biol Commun. 2019 Sep 1;75(Pt 9):586-592. Epub 2019 Aug 30.
DOI: 10.1107/S2053230X19010902 | PUBMED: 31475925 | IF(2019) = 0.97
PDB [P14]: 4UQF

280: Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.
Giastas P, Mpakali A, Papakyriakou A, Lelis A, Kokkala P, Neu M, Rowland P, Liddle J, Georgiadis D, Stratikos
Proc Natl Acad Sci U S A. 2019 Dec
DOI: 10.1073/pnas.1912070116 | PUBMED: 31843903 | IF(2019) = 9.4
PDB [P13]: 6RYF 6RQX

279: Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype.
Driller R, Ballaschk M, Schmieder P, Uchanska-Ziegler B, Ziegler A, Loll B,
J Biol Chem. 2019 Sep 6;294(36):13269-13279. Epub 2019 Jul 11.
DOI: 10.1074/jbc.RA119.008937 | PUBMED: 31296658 | IF(2018) = 4.1
PDB [P14]: 5IB3

278: Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.
Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U
Cell. 2019 Dec 12;179(7):1537-1550.e19.
DOI: 10.1016/j.cell.2019.11.024 | PUBMED: 31835032 | IF(2018) = 36.2
PDB [P13]: 6RFG

277: Visualization of protein crystals by high-energy phase-contrast X-ray imaging.
Polikarpov M, Bourenkov G, Snigireva I, Snigirev A, Zimmermann S, Csanko K, Brockhauser S, Schneider TR,
Acta Crystallogr D Struct Biol. 2019 Nov 1;75(Pt 11):947-958. Epub 2019 Oct 31.
DOI: 10.1107/S2059798319011379 | PUBMED: 31692469 | IF(2018) = 3.2
PDB [P14]:

276: Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.
de Mare SW, Venskutonyte R, Eltschkner S, de Groot BL, Lindkvist-Petersson K,
Structure. 2019 Nov 29.
DOI: 10.1016/j.str.2019.11.011 | PUBMED: 31831212 | IF(2018) = 4.9
PDB [P13]: 6QZJ 6QZI

275: The Structure of the Elusive Urease-Urea Complex Unveils the Mechanism of a Paradigmatic Nickel-Dependent Enzyme.
Mazzei L, Cianci M, Benini S, Ciurli S,
Angew Chem Int Ed Engl. 2019 May 27;58(22):7415-7419. Epub 2019 Apr 30.
DOI: 10.1002/ANIE.201903565 | PUBMED: 30969470 | IF(2019) = 13.0
PDB [P13]: 6QDY

274: Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold.
Sykorova P, Novotna J, Demo G, Pompidor G, Dubska E, Komarek J, Fujdiarova E, Houser J, Haronikova L, Varrot A, Shilova N, Imberty A, Bovin N, Pokorna M, Wimmerova M,
Int J Biol Macromol. 2019 Nov 18.
DOI: 10.1016/J.IJBIOMAC.2019.10.200 | PUBMED: 31751748 | IF(2018) = 4.8
PDB [P13]: 6GXR 6GXS

273: Molecular insight into a new low-affinity xylan binding module from thexylanolytic gut symbiont Roseburia intestinalis.
Leth ML, Ejby M, Madland E, Kitaoku Y, Slotboom DJ, Guskov A, Aachmann FL, Abou Hachem M,
FEBS J. 2019 Nov 6.
DOI: 10.1111/FEBS.15117 | PUBMED: 31693302 | IF(2018) = 4.7
PDB [P13]: 6SGF

272: Unique structure and function of viral rhodopsins.
Bratanov D, Kovalev K, Machtens JP, Astashkin R, Chizhov I, Soloviov D, Volkov D, Polovinkin V, Zabelskii D, Mager T, Gushchin I, Rokitskaya T, Antonenko Y, Alekseev A, Shevchenko V, Yutin N, Rosselli R, Baeken C, Borshchevskiy V, Bourenkov G, Popov A, Balandin T, Buldt G, Manstein DJ, Rodriguez-Valera F, Fahlke C, Bamberg E, Koonin E, Gordeliy V,
Nat Commun. 2019 Oct 30;10(1):4939.
DOI: 10.1038/S41467-019-12718-0 | PUBMED: 31666521 | IF(2022) = 14.9
PDB [P14]: 6SQG 6XYT

271: Optical performance and radiation stability of polymer X-ray refractive nano-lenses.
Barannikov A, Polikarpov M, Ershov P, Bessonov V, Abrashitova K, Snigireva I, Yunkin V, Bourenkov G, Schneider T, Fedyanin AA, Snigirev A,
J Synchrotron Rad. 2019 May 1;26(Pt 3):714-719. Epub 2019 Apr 1.
DOI: 10.1107/S1600577519001656 | PUBMED: | IF(2018) = 2.5
PDB [P14]:

270: Molecular features of the UNC-45 chaperone critical for binding and foldingmuscle myosin.
Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T
Nat Commun. 2019 Oct 21;10(1):4781.
DOI: 10.1038/S41467-019-12667-8 | PUBMED: 31636255 | IF(2022) = 14.9
PDB [P13]: 6QDJ

269: CRL-based ultra-compact transfocator for X-ray focusing and microscopy.
Narikovich A, Polikarpov M, Barannikov A, Klimova N, Lushnikov A, Lyatun I, Bourenkov G, Zverev D, Panormov I, Sinitsyn A, Snigireva I, Snigirev A,
J Synchrotron Rad. 2019 Jul 1;26(Pt 4):1208-1212. Epub 2019 Jun 18.
DOI: 10.1107/S1600577519005708 | PUBMED: | IF(2018) = 2.5
PDB [P14]:

268: Crystal structure of the EcoKMcrA N-terminal domain (NEco): recognition of modified cytosine bases without flipping.
Slyvka A, Zagorskaite E, Czapinska H, Sasnauskas G, Bochtler M,
Nucleic Acids Res. 2019 Nov 14.
DOI: 10.1093/nar/gkz1017 | PUBMED: 31724709 | IF(2018) = 11.1
PDB [P14]: 6T22 6T21

267: Metal binding to the dynamic cytoplasmic domain of the cation diffusionfacilitator (CDF) protein MamM induces a 'locked-in' configuration.
Barber-Zucker S, Hall J, Mangapuram SV, Kass I, Kolusheva S, MacMillan F, Zarivach R, Henn A,
FEBS J. 2019 Jun;286(11):2193-2215. Epub 2019 Mar 20.
DOI: 10.1111/febs.14795 | PUBMED: 30811856 | IF(2018) = 4.7
PDB [P13]: 6G55

266: UNEXPECTED ENZYME-CATALYSED [4+2] CYCLOADDITION AND REARRANGEMENT IN POLYETHER ANTIBIOTIC BIOSYNTHESIS
R.LITTLE,F.C.R.PAIVA,R.JENKINS,H.HONG,Y.SUN,Y.DEMYDCHUK, M.SAMBORSKYY,M.TOSIN,F.J.LEEPER,M.V.B.DIAS,P.F.LEADLAY
Nat Catal. 2019 2:1045-1054
DOI: 10.1038/S41929-019-0351-2 | PUBMED: NONE
PDB [P13]: 6NNW

265: The Crystal Structure of the Plasmodium falciparum PdxK Provides an Experimental Model for Pro-Drug Activation
Gao K, Wang W, Kronenberger T, Wrenger C, Groves MR
Crystals. 2019 9(10): 534
DOI: 10.3390/CRYST9100534 | PUBMED: | IF(2018) = 2.4
PDB [P13]: 6SU9

264: Liquid application method for time-resolved analyses by serial synchrotron crystallography.
Mehrabi P, Schulz EC, Agthe M, Horrell S, Bourenkov G, von Stetten D, Leimkohl JP, Schikora H, Schneider TR, Pearson AR, Tellkamp F, Miller RJD
Nat Methods. 2019 Oct;16(10):979-982. Epub 2019Sep 16.
DOI: 10.1038/S41592-019-0553-1 | PUBMED: 31527838 | IF(2018) = 28.5
PDB [P14]: 6RNC 6RNB 6RND 6RNF 6QNJ 6QNH 6QNI 6QND 6QNB 6QNC

263: Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
Voss M, Toelzer C, Bhandari DD, Parker JE, Niefind K
J Struct Biol. 2019 Sep 21.
DOI: 10.1016/J.JSB.2019.09.007 | PUBMED: 31550533 | IF(2018) = 3.8
PDB [P13]: 6I8H

262: Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal are negatively coupled.
Moritzer AC, Niemann HH
Protein Sci. 2019 Oct 7.
DOI: 10.1002/PRO.3739 | PUBMED: 31589794 | IF(2018) = 2.4
PDB [P13]: 6SLT 6SLS

261: Sub-Atomic Resolution Crystal Structures Reveal Conserved Geometric Outliers atFunctional Sites.
Laulumaa S, Kursula P,
Molecules. 2019 Aug 22;24(17).
DOI: 10.3390/molecules24173044. | PUBMED: 31443388 | IF(2020) = 3.3
PDB [P13]: 6S2S

260: Marine Proteobacteria metabolize glycolate via the beta-hydroxyaspartate cycle.
Schada von Borzyskowski L, Severi F, Kruger K, Hermann L, Gilardet A, Sippel F, Pommerenke B, Claus P, Cortina NS, Glatter T, Zauner S, Zarzycki J, Fuchs BM, Bremer E, Maier UG, Amann RI, Erb TJ,
Nature. 2019 Nov;575(7783):500-504. Epub 2019 Nov13.
DOI: 10.1038/s41586-019-1748-4 | PUBMED: 31723261 | IF(2018) = 43.1
PDB [P13]: 6RQA

259: High-throughput peptide-MHC complex generation and kinetic screenings of TCRswith peptide-receptive HLA-A*02:01 molecules.
Moritz A, Anjanappa R, Wagner C, Bunk S, Hofmann M, Pszolla G, Saikia A, Garcia-Alai M, Meijers R, Rammensee HG, Springer S, Maurer D,
Sci Immunol. 2019 Jul 19;4(37).
DOI: 10.1126/sciimmunol.aav0860 | PUBMED: 31324691 | IF(2018) = 10.5
PDB [P13]: 6Q3K 6Q3S

258: Structural insights into synthetic ligands targeting A-A pairs in disease-relatedCAG RNA repeats.
Mukherjee S, Blaszczyk L, Rypniewski W, Falschlunger C, Micura R, Murata A, Dohno C, Nakatani K, Kiliszek A,
Nucleic Acids Res. 2019 Nov 18;47(20):10906-10913.
DOI: 10.1093/nar/gkz832 | PUBMED: 31566242 | IF(2018) = 11.1
PDB [P13]: 6QIQ

257: Active Site Architecture and Reaction Mechanism Determination of Cold Adapted beta-d-galactosidase from Arthrobacter sp. 32cB.
Rutkiewicz M, Bujacz A, Wanarska M, Wierzbicka-Wos A, Cieslinski H
Int J Mol Sci. 2019 Sep 3;20(17).
DOI: 10.3390/ijms20174301 | PUBMED: 31484304 | IF(2018) = 4.2
PDB [P13]: 6SE8

256: Low-barrier hydrogen bonds in enzyme cooperativity.
Dai S, Funk LM, von Pappenheim FR, Sautner V, Paulikat M, Schroder B, Uranga J, Mata RA, Tittmann K,
Nature. 2019 Sep 18.
DOI: 10.1038/s41586-019-1581-9 | PUBMED: 31534226 | IF(2018) = 43.1
PDB [P13P14]: 6HAD 6HA3 6RJB 6RJC 6HAF

255: Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Pedersen DV, Gadeberg TAF, Thomas C, Wang Y, Joram N, Jensen RK, Mazarakis SMM, Revel M, El Sissy C, Petersen SV, Lindorff-Larsen K, Thiel S, Laursen NS, Fremeaux-Bacchi V, Andersen GR,
Front Immunol. 2019 Aug 22;10:2007. eCollection2019.
DOI: 10.3389/fimmu.2019.02007 | PUBMED: 31507604 | IF(2018) = 6.4
PDB [P13P14]: 6SEJ 6RV6 6RUV 6RUR 6RU5 6RU3

254: Time-resolved crystallography reveals allosteric communication aligned withmolecular breathing.
Mehrabi P, Schulz EC, Dsouza R, Muller-Werkmeister HM, Tellkamp F, Miller RJD, Pai EF,
Science. 2019 Sep 13;365(6458):1167-1170.
DOI: 10.1126/SCIENCE.AAW9904 | PUBMED: 31515393 | IF(2018) = 41.1
PDB [P14]: 6QI1 6QHY 6QHX

253: The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNABinding Domain.
Manav MC, Turnbull KJ, Jurenas D, Garcia-Pino A, Gerdes K, Brodersen DE,
Structure. 2019 Sep 4.
DOI: 10.1016/J.STR.2019.08.008 | PUBMED: 31495532 | IF(2018) = 4.9
PDB [P13P14]: 6HPB 6HPC

252: Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure andAffinities of Inhibitors.
Kazokaite J, Kairys V, Smirnoviene J, Smirnov A, Manakova E, Tolvanen M, Parkkila S, Matulis D,
Sci Rep. 2019 Sep 3;9(1):12710.
DOI: 10.1038/S41598-019-49094-0 | PUBMED: 31481705 | IF(2018) = 4.1
PDB [P14]: 6QL3 6QL2 6QL1

251: Ternary structure of the outer membrane transporter FoxA with resolved signallingdomain provides insights into TonB-mediated siderophore uptake.
Josts I, Veith K, Tidow H
Elife. 2019 Aug 6;8.
DOI: 10.7554/ELIFE.48528 | PUBMED: 31385808 | IF(2018) = 7.6
PDB [P13]: 6I98 6I97

250: Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S byAutoubiquitination.
Liess AKL, Kucerova A, Schweimer K, Yu L, Roumeliotis TI, Diebold M, Dybkov O, Sotriffer C, Urlaub H, Choudhary JS, Mansfeld J, Lorenz S
Structure. 2019 Jun 4.
DOI: 10.1016/J.STR.2019.05.008 | PUBMED: 31230944 | IF(2018) = 4.9
PDB [P14]: 6QH3

249: Class Id ribonucleotide reductase utilizes a Mn2(IV,III) cofactor and undergoes large conformational changes on metal loading.
Rozman Grinberg I, Berglund S, Hasan M, Lundin D, Ho FM, Magnuson A, Logan DT, Sjoberg BM, Berggren G
J Biol Inorg Chem. 2019 Aug 14.
DOI: 10.1007/S00775-019-01697-8 | PUBMED: 31414238 | IF(2018) = 3.6
PDB [P13P14]: 6SF5 6SF4

248: Atomic view into Plasmodium actin polymerization, ATP hydrolysis, andfragmentation.
Kumpula EP, Lopez AJ, Tajedin L, Han H, Kursula I
PLoS Biol. 2019 Jun 14;17(6):e3000315.
DOI: 10.1371/JOURNAL.PBIO.3000315 | PUBMED: 31199804 | IF(2018) = 8.4
PDB [P13]: 6I4M 6I4D 6I4E

247: Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1.
Pichlo C, Juetten L, Wojtalla F, Schacherl M, Diaz D, Baumann U,
J Biol Chem. 2019 Jun 10.
DOI: 10.1074/jbc.RA119.009029 | PUBMED: 31182482 | IF(2018) = 4.1
PDB [P13]: 6R59 6R4X

246: NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly highligand release efficacy.
Gardill BR, Schmidt K, Muller YA,
J Struct Biol. 2019 May 16.
DOI: 10.1016/J.JSB.2019.05.006 | PUBMED: 31103428 | IF(2018) = 3.8
PDB [P13]: 6HGG 6HGJ 6HGI 6HGK

245: Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
Andres F, Iamele L, Meyer T, Stuber JC, Kast F, Gherardi E, Niemann HH, Pluckthun A,
J Mol Biol. 2019 May 3;431(10):2020-2039. Epub2019 Mar 28.
DOI: 10.1016/J.JMB.2019.03.024 | PUBMED: 30930049 | IF(2018) = 5.1
PDB [P13]: 6GCU

244: Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to asubstrate.
Palm GJ, Reisky L, Bottcher D, Muller H, Michels EAP, Walczak MC, Berndt L, Weiss MS, Bornscheuer UT, Weber G,
Nat Commun. 2019 Apr 12;10(1):1717.
DOI: 10.1038/S41467-019-09326-3 | PUBMED: 30979881 | IF(2022) = 14.9
PDB [P13]: 6QGC

243: Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in theBiosynthesis of Gentamicin.
de Araujo NC, Bury PDS, Tavares MT, Huang F, Parise-Filho R, Leadlay P, Dias MVB,
ACS Chem Biol. 2019 May 17;14(5):925-933. Epub2019 Apr 30.
DOI: 10.1021/ACSCHEMBIO.9B00115 | PUBMED: 30995396 | IF(2019) = 4.43
PDB [P13]: 6NOR

242: A surface-exposed GH26 beta-mannanase from Bacteroides ovatus: Structure, role, and phylogenetic analysis of BoMan26B.
Bagenholm V, Wiemann M, Reddy SK, Bhattacharya A, Rosengren A, Logan DT, Stalbrand H,
J Biol Chem. 2019 Jun 7;294(23):9100-9117. Epub2019 Apr 18.
DOI: 10.1074/jbc.RA118.007171 | PUBMED: 31000630 | IF(2018) = 4.1
PDB [P13]: 6HF2

241: Structural Insights into Curli CsgA Cross-beta Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents.
Perov S, Lidor O, Salinas N, Golan N, Tayeb-Fligelman E, Deshmukh M, Willbold D, Landau M
PLoS Pathog. 2019 Aug 30;15(8):e1007978. eCollection 2019 Aug.
DOI: 10.1371/journal.ppat.1007978 | PUBMED: 31469892 | IF(2018) = 6.1
PDB [P14]: 6G8C 6G8D 6G9G

240: CH-PI INTERACTIONS PROMOTE THE CONVERSION OF HYDROXYPYRUVATE IN A CLASS II PYRUVATE ALDOLASE
S.R.MARSDEN,L.MESTROM,I.BENTO,P.L.HAGEDOORN,D.G.G.MCMILLAN, U.HANEFELD
Adv Synth Catal. 2019 , 361
DOI: 10.1002/ADSC.201900205 | PUBMED: | IF(2018) = 5.5
PDB [P13]: 6R62

239: (p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch.
Zhang YE, Baerentsen RL, Fuhrer T, Sauer U, Gerdes K, Brodersen DE,
Mol Cell. 2019 Apr 16.
DOI: 10.1016/J.MOLCEL.2019.03.035 | PUBMED: 31023582 | IF(2018) = 14.5
PDB [P13]: 6GFM

238: Crystal structures of the c-di-AMP synthesizing enzyme CdaA.
Heidemann JL, Neumann P, Dickmanns A, Ficner R,
J Biol Chem. 2019 May 22.
DOI: 10.1074/JBC.RA119.009246 | PUBMED: 31118276 | IF(2018) = 4.1
PDB [P13P14]: 6HVM 6HVN 6HVL

237: Structure of a functional cap-binding domain in Rift Valley fever virus Lprotein.
Gogrefe N, Reindl S, Gunther S, Rosenthal M,
PLoS Pathog. 2019 May 28;15(5):e1007829.
DOI: 10.1371/JOURNAL.PPAT.1007829 | PUBMED: 31136637 | IF(2018) = 6.1
PDB [P13]: 6QHG

236: Protein crystallization promotes type 2 immunity and is reversible by antibodytreatment.
Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Goncalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN,
Science. 2019 May 24;364(6442).
DOI: 10.1126/SCIENCE.AAW4295 | PUBMED: 31123109 | IF(2018) = 41.1
PDB [P14]: 6QRN 6GKS 6GKQ

235: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebscycle.
Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K,
Nature. 2019 Apr 3.
DOI: 10.1038/S41586-019-1095-5 | PUBMED: 30944476 | IF(2018) = 43.1
PDB [P13P14]: 6HXK 6QCL 6QFB

234: Structural Comparison of Enterococcus faecalis and Human Thymidylate SynthaseComplexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints aboutEnzyme Conformational Variabilities.
Pozzi C, Ferrari S, Luciani R, Tassone G, Costi MP, Mangani S,
Molecules. 2019 Mar 31;24(7).
DOI: 10.3390/MOLECULES24071257 | PUBMED: 30935102 | IF(2020) = 3.3
PDB [P14]: 6QXH

233: Structural basis for RNA translocation by DEAH-box ATPases.
Hamann F, Enders M, Ficner R,
Nucleic Acids Res. 2019 Mar 4.
DOI: 10.1093/NAR/GKZ150 | PUBMED: 30828714 | IF(2018) = 11.1
PDB [P13]: 6I3O 6QIE 6QIC 6I3P

232: Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by aReliable Path to Atomic Resolution CK2alpha' Structures.
Lindenblatt D, Nickelsen A, Applegate VM, Hochscherf J, Witulski B, Bouaziz Z, Marminon C, Bretner M, Le Borgne M, Jose J, Niefind K,
ACS Omega. 2019 Mar 19;4(3):5471-5478. eCollection2019 Mar 31.
DOI: 10.1021/acsomega.8b03415 | PUBMED: 31559376 | IF(2018) = 2.6
PDB [P13]: 6HME

231: High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor.
Giastas P, Neu M, Rowland P, Stratikos E,
ACS Med Chem Lett. 2019 Feb 13;10(5):708-713. eCollection 2019 May 9.
DOI: 10.1021/ACSMEDCHEMLETT.9B00002 | PUBMED: 31097987 | IF(2018) = 3.7
PDB [P13]: 6Q4R

230: An NAD(+) Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.
Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Svergun DI, Schnappinger D, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O,
Mol Cell. 2019 Mar 21;73(6):1282-1291.e8. Epub2019 Feb 18.
DOI: 10.1016/j.molcel.2019.01.028 | PUBMED: 30792174 | IF(2018) = 14.5
PDB [P13]: 6FKG

229: Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 InhibitorsModified with Chiral Pyrrolidine Scaffolds.
Luxenburger A, Schmidt D, Ianes C, Pichlo C, Kruger M, von Drathen T, Brunstein E, Gainsford GJ, Baumann U, Knippschild U, Peifer C,
Molecules. 2019 Mar 1;24(5).
DOI: 10.3390/MOLECULES24050873 | PUBMED: 30832206 | IF(2020) = 3.3
PDB [P13]: 6F1W

228: Active site complementation and hexameric arrangement in the GH family 29; astructure-function study of alpha-l-fucosidase isoenzyme 1 from Paenibacillusthiaminolyticus.
Kovalova T, Koval T, Benesova E, Vodickova P, Spiwok V, Lipovova P, Dohnalek J,
Glycobiology. 2019 Jan 1;29(1):59-73.
DOI: 10.1093/GLYCOB/CWY078 | PUBMED: 30544181 | IF(2018) = 4.2
PDB [P13]: 6GN6

227: Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
Cruz-Migoni A, Canning P, Quevedo CE, Bataille CJR, Bery N, Miller A, Russell AJ, Phillips SEV, Carr SB, Rabbitts TH,
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2545-2550. Epub 2019 Jan 25.
DOI: 10.1073/PNAS.1811360116 | PUBMED: 30683716 | IF(2019) = 9.4
PDB [P14]: 6GQW 6GQY 6GQX

226: Long-wavelength Mesh&Collect native SAD phasing from microcrystals.
Cianci M, Nanao M, Schneider TR,
Acta Crystallogr D Struct Biol. 2019 Feb 1;75(Pt 2):192-199. Epub 2019 Feb 11.
DOI: 10.1107/S2059798319002031 | PUBMED: 30821707 | IF(2018) = 3.2
PDB [P13]: 6H2M

225: Structural and computational basis for potent inhibition of glutamatecarboxypeptidase II by carbamate-based inhibitors.
Barinka C, Novakova Z, Hin N, Bim D, Ferraris DV, Duvall B, Kabarriti G, Tsukamoto R, Budesinsky M, Motlova L, Rojas C, Slusher BS, Rokob TA, Rulisek L, Tsukamoto T.
Bioorg Med Chem. 2019 Jan 15;27(2):255-264. Epub 2018 Nov 14.
DOI: 10.1016/j.bmc.2018.11.022 | PUBMED: 30552009 | IF(2018) = 2.5
PDB [P13]: 6EZ9 6FE5 6ETY 6F5L

224: Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.
Ural-Blimke Y, Flayhan A, Strauss J, Rantos V, Bartels K, Nielsen R, Pardon E, Steyaert J, Kosinski J, Quistgaard EM, Low C,
J Am Chem Soc. 2019 Jan 31.
DOI: 10.1021/JACS.8B11343 | PUBMED: 30644743 | IF(2018) = 14.7
PDB [P13]: 6GS4 6GS7

223: Enzyme activity and structural features of three single-domain phloemcyclophilins from Brassica napus.
Hanhart P, Falke S, Garbe M, Rose V, Thiess M, Betzel C, Kehr J,
Sci Rep. 2019 Jun 27;9(1):9368.
DOI: 10.1038/s41598-019-45856-y | PUBMED: 31249367 | IF(2018) = 4.1
PDB [P14]: 6HMZ

222: Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
Merő B, Radnai L, Gógl G, Tőke O, Leveles I, Koprivanacz K, Szeder B, Dülk M, Kudlik G, Vas V, Cserkaszky A, Sipeki S, Nyitray L, Vértessy BG, Buday L.
J Biol Chem. (2019 Mar)294:4608-4620
DOI: 10.1074/jbc.ra118.004732 | PUBMED: 30659095 | IF(2018) = 4.1
PDB [P13]: 5NP2 5NP5 5NP3

221: Diamondoid Amino Acid-Based Peptide Kinase A Inhibitor Analogues.
Muller J, Kirschner RA, Berndt JP, Wulsdorf T, Metz A, Hrdina R, Schreiner PR, Geyer A, Klebe G,
ChemMedChem. 2019 Mar 22;14(6):663-672. Epub 2019Feb 19.
DOI: 10.1002/cmdc.201800779 | PUBMED: 30677243 | IF(2018) = 3.0
PDB [P13]: 5OK3

Number of publications for 2019: 66

2018

220: Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics byl,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis.
Libreros-Zuniga GA, Dos Santos Silva C, Salgado Ferreira R, Dias MVB,
ACS Infect Dis. 2019 Feb 8;5(2):260-271. Epub2018 Dec 28.
DOI: 10.1021/ACSINFECDIS.8B00244 | PUBMED: 30556998 | IF(2018) = 5.0
PDB [P13]: 6D4K

219: Design of two-tail compounds with rotationally fixed benzenesulfonamide ring asinhibitors of carbonic anhydrases.
Zaksauskas A, Capkauskaite E, Jezepcikas L, Linkuviene V, Kisonaite M, Smirnov A, Manakova E, Grazulis S, Matulis D,
Eur J Med Chem. 2018 Aug 5;156:61-78. Epub2018 Jun 27.
DOI: 10.1016/J.EJMECH.2018.06.059 | PUBMED: 30006175 | IF(2018) = 4.8
PDB [P14]: 6G6T 6G7A 6G5L

218: Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.
Scheide-Noeth JP, Rosen M, Baumstark D, Dietz H, Mueller TD,
J Mol Biol. 2018 Dec 7.
DOI: 10.1016/J.JMB.2018.11.029 | PUBMED: 30529748 | IF(2018) = 5.1
PDB [P13]: 6H41

217: Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMalpha peptides.
Salinas N, Colletier JP, Moshe A, Landau M
Nat Commun. 2018 Aug 29;9(1):3512.
DOI: 10.1038/s41467-018-05490-0 | PUBMED: 30158633 | IF(2022) = 14.9
PDB [P14]: 6FHD

216: Structural and functional characterization of a family GH53 beta-1,4-galactanase from Bacteroides thetaiotaomicron that facilitates degradation of prebioticgalactooligosaccharides.
Boger M, Hekelaar J, van Leeuwen SS, Dijkhuizen L, Lammerts van Bueren A,
J Struct Biol. 2018 Dec 13.
DOI: 10.1016/J.JSB.2018.12.002 | PUBMED: 30553858 | IF(2018) = 3.8
PDB [P13]: 6GPA

215: Structure-based switch of regioselectivity in the flavin-dependent tryptophan6-halogenase Thal.
Moritzer AC, Minges H, Prior T, Frese M, Sewald N, Niemann HH,
J Biol Chem. 2018 Dec 17.
DOI: 10.1074/JBC.RA118.005393 | PUBMED: 30559288 | IF(2018) = 4.1
PDB [P13]: 6IB5 6H44 6H43

214: The cost of long catalytic loops in folding and stability of the ALS-associatedprotein SOD1.
Yang F, Wang H, Logan DT, Mu X, Danielsson J, Oliveberg M,
J Am Chem Soc. 2018 Oct 25.
DOI: 10.1021/JACS.8B08141 | PUBMED: 30359015 | IF(2018) = 14.7
PDB [P14]: 6FLH

213: The hit-and-return system enables efficient time-resolved serial synchrotron crystallography.
Schulz EC, Mehrabi P, Muller-Werkmeister HM, Tellkamp F, Jha A, Stuart W, Persch E, De Gasparo R, Diederich F, Pai EF, Miller RJD,
Nat Methods. 2018 Nov;15(11):901-904. Epub 2018Oct 30.
DOI: 10.1038/S41592-018-0180-2 | PUBMED: 30377366 | IF(2018) = 28.5
PDB [P14]: 6FSX 6GXH 6GXT

212: Crystal structure of human mARC1 reveals its exceptional position amongeukaryotic molybdenum enzymes.
Kubitza C, Bittner F, Ginsel C, Havemeyer A, Clement B, Scheidig AJ, ORCID: 0000-0002-2382-8818,
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):11958-11963. Epub 2018 Nov 5.
DOI: 10.1073/pnas.1808576115 | PUBMED: 30397129 | IF(2019) = 9.4
PDB [P14]: 6FW2

211: Characterization of the catalytic flexible loop in the dihydroorotase domain ofthe human multi-enzymatic protein CAD.
Del Cano-Ochoa F, Grande-Garcia A, Reverte-Lopez M, D'Abramo M, Ramon-Maiques S,
J Biol Chem. 2018 Oct 12.
DOI: 10.1074/JBC.RA118.005494 | PUBMED: 30315107 | IF(2018) = 4.1
PDB [P13]: 6HFS 6HFR 6HFQ 6HFP 6HFU 6HFK 6HFJ 6HFH 6HFN 6HFL

210: Towards a comprehensive understanding of the structural dynamics of a bacterialditerpene synthase during catalysis.
Driller R, Janke S, Fuchs M, Warner E, Mhashal AR, Major DT, Christmann M, Bruck T, Loll B
Nat Commun. 2018 Sep 28;9(1):3971.
DOI: 10.1038/S41467-018-06325-8 | PUBMED: 30266969 | IF(2022) = 14.9
PDB [P14]: 6GGL

209: Recognition of modified cytosine variants by the DNA-binding domain ofmethyl-directed endonuclease McrBC.
Zagorskaite E, Manakova E, Sasnauskas G,
FEBS Lett. 2018 Sep 8.
DOI: 10.1002/1873-3468.13244 | PUBMED: 30194838 | IF(2018) = 2.7
PDB [P13]: 6GCF

208: DNA recognition by Arabidopsis transcription factors ABI3 and NGA1
Sasnauskas G, Manakova E, Lapenas K, Kauneckaite K, Siksnys V
FEBS J. 2018 Nov;285(21):4041-4059.
DOI: 10.1111/febs.14649. Epub 2018 Sep 21. | PUBMED: 30183137. | IF(2018) = 4.7
PDB [P14]: 5OS9

207: Tripeptide binding in a proton-dependent oligopeptide transporter.
Martinez Molledo M, Quistgaard EM, Low C,
FEBS Lett. 2018 Sep 8.
DOI: 10.1002/1873-3468.13246 | PUBMED: 30194725 | IF(2018) = 2.7
PDB [P14]: 6GHJ

206: Crystal Structure of the Escherichia coli DExH-Box NTPase HrpB.
Pietrzyk-Brzezinska AJ, Absmeier E, Klauck E, Wen Y, Antelmann H, Wahl MC,
Structure. 2018 Aug 13.
DOI: 10.1016/J.STR.2018.07.013 | PUBMED: 30174149 | IF(2018) = 4.9
PDB [P14]: 6EUD

205: Intriguing role of water in protein-ligand binding studied by neutroncrystallography on trypsin complexes.
Schiebel J, Gaspari R, Wulsdorf T, Ngo K, Sohn C, Schrader TE, Cavalli A, Ostermann A, Heine A, Klebe G
Nat Commun. 2018 Sep 3;9(1):3559.
DOI: 10.1038/s41467-018-05769-2 | PUBMED: 30177695 | IF(2022) = 14.9
PDB [P14]: 5MNE 5MNN 5MNG 5MNQ 5MNF 5MNH 5MOP 5MOQ 5MOS

204: Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic SubunitQTRT1.
Johannsson S, Neumann P, Ficner R,
Biomolecules. 2018 Aug 24;8(3).
DOI: 10.3390/BIOM8030081 | PUBMED: 30149595 | IF(2019) = 4.7
PDB [P14]: 6H45 6H42

203: Structural and Functional Characterization of the BcsG Subunit of the CelluloseSynthase in Salmonella typhimurium.
Sun L, Vella P, Schnell R, Polyakova A, Bourenkov G, Li F, Cimdins A, Schneider TR, Lindqvist Y, Galperin MY, Schneider G, Romling U,
J Mol Biol. 2018 Jul 12.
DOI: 10.1016/j.jmb.2018.07.008 | PUBMED: 30017920 | IF(2018) = 5.1
PDB [P14]: 5OLT

202: Activity and structure of EcoKMcrA.
Czapinska H, Kowalska M, Zagorskaite E, Manakova E, Slyvka A, Xu SY, Siksnys V, Sasnauskas G, Bochtler M,
Nucleic Acids Res. 2018 Aug 10.
DOI: 10.1093/nar/gky731. | PUBMED: 30107581 | IF(2018) = 11.1
PDB [P13]: 5OJH 6GHC

201: NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward theEPHrin Family.
Troster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Muller S, Kuster B, Medard G, Kudlinzki D, Schwalbe H,
ChemMedChem. 2018 Jun 21.
DOI: 10.1002/CMDC.201800398 | PUBMED: 29928781 | IF(2018) = 3.0
PDB [P13]: 6FNF 6FNH 6FNG

200: Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Sokolov AV, Dadinova LA, Petoukhov MV, Bourenkov G, Dubova KM, Amarantov SV, Volkov VV, Kostevich VA, Gorbunov NP, Grudinina NA, Vasilyev VB, Samygina VR,
Biochemistry (Mosc). 2018 Jun;83(6):701-707.
DOI: 10.1134/S000629791806007X | PUBMED: 30195326 | IF(2018) = 3.0
PDB [P14]: 6FVE

199: Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiencyby the tRNA nucleoside queuosine.
Johannsson S, Neumann P, Wulf A, Welp LM, Gerber HD, Krull M, Diederichsen U, Urlaub H, Ficner R,
Sci Rep. 2018 Jun 11;8(1):8880.
DOI: 10.1038/S41598-018-27118-5 | PUBMED: 29892076 | IF(2018) = 4.1
PDB [P13]: 6FDF

198: Structural and functional insights into the unique CBS-CP12 fusion protein familyin cyanobacteria.
Hackenberg C, Hakanpaa J, Cai F, Antonyuk S, Eigner C, Meissner S, Laitaoja M, Janis J, Kerfeld CA, Dittmann E, Lamzin VS,
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7141-7146. Epub 2018 Jun 18.
DOI: 10.1073/pnas.1806668115 | PUBMED: 29915055 | IF(2019) = 9.4
PDB [P13]: 5NPL 5NVD 5NMU

197: Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Schmidt K, Gardill BR, Kern A, Kirchweger P, Borsch M, Muller YA,
Proc Natl Acad Sci U S A. 2018 May 14.
DOI: 10.1073/PNAS.1716666115 | PUBMED: 29760101 | IF(2019) = 9.4
PDB [P14]: 5OM3 5OM5

196: Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.
Peterson K, Kumar R, Stenstrom O, Verma P, Verma PR, Hakansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ,
J Med Chem. 2018 Feb 8;61(3):1164-1175. Epub2018 Jan 11.
DOI: 10.1021/ACS.JMEDCHEM.7B01626 | PUBMED: 29284090 | IF(2018) = 6.1
PDB [P13]: 5ODY

195: Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus.
Kubitza C, Faust A, Gutt M, ORCID: 0000-0001-5629-7665, Gath L, Ober D, Scheidig AJ,
Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):422-432. Epub 2018 Apr 24.
DOI: 10.1107/S2059798318003510. | PUBMED: 29717713 | IF(2018) = 3.2
PDB [P14]: 5NMX 5NMW

194: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
Jensen RK, Pihl R, Gadeberg TAF, Jensen JK, Andersen KR, Thiel S, Laursen NS, Andersen GR,
J Biol Chem. 2018 Apr 27;293(17):6269-6281. Epub2018 Mar 1.
DOI: 10.1107/S1600576717014479 | PUBMED: 29497000 | IF(2018) = 4.1
PDB [P14]: 6EHG

193: Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors.
Pernigo S, Chegkazi MS, Yip YY, Treacy C, Glorani G, Hansen K, Politis A, Bui S, Dodding MP, Steiner RA
Elife. 2018 Oct 15;7.
DOI: 10.7554/eLife.38362 | PUBMED: 30320553 | IF(2018) = 7.6
PDB [P14]: 6FUZ

192: p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P
Nat Commun. 2018 Mar 9;9(1):1017.
DOI: 10.1107/S1600576717014479 | PUBMED: 29523821 | IF(2022) = 14.9
PDB [P14]: 6EIH

191: The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific.
Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Sturzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C,
J Virol. 2018 May 9.
DOI: 10.1128/JVI.00226-18. | PUBMED: 29743357 | IF(2018) = 4.3
PDB [P14]: 6GFC

190: Multispecific Substrate Recognition in a Proton-Dependent OligopeptideTransporter.
Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Low C,
Structure. 2018 Mar 6;26(3):467-476.e4. Epub 2018Feb 8.
DOI: 10.1016/j.str.2018.01.005 | PUBMED: 29429879 | IF(2018) = 4.9
PDB [P14]: 5OXK 5OXP 5OXO 5OXN 6EIA 5OXQ

189: Structural basis of DNA target recognition by the B3 domain of Arabidopsisepigenome reader VAL1.
Sasnauskas G, Kauneckaite K, Siksnys V
Nucleic Acids Res. 2018 Apr 6.
DOI: 10.1093/NAR/GKY256 | PUBMED: 29660015 | IF(2018) = 11.1
PDB [P14]: 6FAS

188: The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1helicase-like motor.
Toliusis P, Tamulaitiene G, Grigaitis R, Tuminauskaite D, Silanskas A, Manakova E, Venclovas C, Szczelkun MD, Siksnys V, Zaremba M,
Nucleic Acids Res. 2018 Mar 16;46(5):2560-2572.
DOI: 10.1093/NAR/GKY107 | PUBMED: 29471489 | IF(2018) = 11.1
PDB [P14]: 6F1S

187: A family of unconventional deubiquitinases with modular chain specificitydeterminants.
Hermanns T, Pichlo C, Woiwode I, Klopffleisch K, Witting KF, Ovaa H, Baumann U, Hofmann K
Nat Commun. 2018 Feb 23;9(1):799.
DOI: 10.1038/S41467-018-03148-5 | PUBMED: 29476094 | IF(2022) = 14.9
PDB [P13]: 6EI1

186: Structure Guided Lead Generation toward Nonchiral M. tuberculosis ThymidylateKinase Inhibitors.
Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Ainsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S
J Med Chem. 2018 Apr 12;61(7):2753-2775. Epub 2018 Mar 15.
DOI: 10.1021/ACS.JMEDCHEM.7B01570 | PUBMED: 29510037 | IF(2018) = 6.1
PDB [P14]: 5NR7

185: Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1through DCC.
Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang JH, Meijers R
Neuron. 2018 Mar 21;97(6):1261-1267.e4. Epub2018 Mar 1.
DOI: 10.1016/J.NEURON.2018.02.010 | PUBMED: 29503192 | IF(2018) = 14.4
PDB [P14]: 6FKQ

184: The structure of hydrogenase-2 from Escherichia coli: implications for H2-driven proton pumping.
Beaton SE, Evans RM, Finney AJ, Lamont CM, Armstrong FA, Sargent F, Carr SB
Biochem J. 2018 Apr 16;475(7):1353-1370.
DOI: 10.1042/BCJ20180053 | PUBMED: 29555844
PDB [P14]: 6EHQ

183: Epsin and Sla2 form assemblies through phospholipid interfaces.
Garcia-Alai MM, Heidemann J, Skruzny M, Gieras A, Mertens HDT, Svergun DI, Kaksonen M, Uetrecht C, Meijers R
Nat Commun. 2018 Jan 23;9(1):328.
DOI: 10.1038/S41467-017-02443-X | PUBMED: 29362354 | IF(2022) = 14.9
PDB [P14]: 6ENR 5ONF 5ON7

182: Transposase-DNA Complex Structures Reveal Mechanisms for ConjugativeTransposition of Antibiotic Resistance.
Rubio-Cosials A, Schulz EC, Lambertsen L, Smyshlyaev G, Rojas-Cordova C, Forslund K, Karaca E, Bebel A, Bork P, Barabas O
Cell. 2018 Mar 22;173(1):208-220.e20. Epub 2018 Mar 15.
DOI: 10.1016/J.CELL.2018.02.032 | PUBMED: 29551265 | IF(2018) = 36.2
PDB [P13]: 6EN1 6EN2 6EN0 6EMY 6EMZ

181: Structural basis for PDZ domain interactions in the post-synaptic densityscaffolding protein Shank3.
Ponna SK, Ruskamo S, Myllykoski M, Keller C, Boeckers TM, Kursula P
J Neurochem. 2018 Feb 23.
DOI: 10.1111/JNC.14322 | PUBMED: 29473168
PDB [P13]: 5OVV 5OVP

180: Structure and stability of the Human respiratory syncytial virus M2-1 RNA-bindingcore domain reveals a compact and cooperative folding unit.
Molina IG, Josts I, Almeida Hernandez Y, Esperante S, Salgueiro M, Garcia Alai MM, de Prat-Gay G, Tidow H,
Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):23-30. Epub 2017 Dec 15.
DOI: 10.1107/S2053230X17017381 | PUBMED: 29372904 | IF(2019) = 0.97
PDB [P13]: 5NOH 5NKX

179: Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.
Petrova OA, Mantsyzov AB, Rodina EV, Efimov SV, Hackenberg C, Hakanpää J, Klochkov VV, Lebedev AA, Chugunova AA, Malyavko AN, Zatsepin TS, Mishin AV, Zvereva MI, Lamzin VS, Dontsova OA, Polshakov VI.
Nucleic Acids Res. (2018 Feb)46:1525-1540
DOI: 10.1093/nar/gkx1275 | PUBMED: 29294091 | IF(2018) = 11.1
PDB [P13]: 5NPT

178: Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus smallalarmone synthetase RelP.
Manav MC, Beljantseva J, Bojer MS, Tenson T, Ingmer H, Hauryliuk V, Brodersen DE,
J Biol Chem. 2018 Jan 11.
DOI: 10.1074/JBC.RA117.001374 | PUBMED: 29326162 | IF(2018) = 4.1
PDB [P13]: 6EWZ

177: Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23Receptor Enables Recruitment of the Shared Receptor IL-12Rbeta1.
Bloch Y, Bouchareychas L, Merceron R, Skladanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN
Immunity. 2018 Jan 16;48(1):45-58.e6. Epub2017 Dec 26.
DOI: 10.1016/J.IMMUNI.2017.12.008 | PUBMED: 29287995 | IF(2018) = 21.5
PDB [P14]: 5NJD 5MXA 5MZV 5M85

176: Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Dolot R, Lam CH, Sierant M, Zhao Q, Liu FW, Nawrot B, Egli M, Yang X
Nucleic Acids Res. 2018 May 18;46(9):4819-4830.
DOI: 10.1093/nar/gky268. | PUBMED: 29684204 | IF(2018) = 11.1
PDB [P13]: 6EO6

175: Structure of the mouse acidic amino acid decarboxylase GADL1.
Raasakka A, Mahootchi E, Winge I, Luan W, Kursula P, Haavik J,
Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):65-73. Epub 2018 Jan 1.
DOI: 10.1107/S2053230X17017848 | PUBMED: 29372909 | IF(2019) = 0.97
PDB [P13]: 6ENZ

174: The dual role of MamB in magnetosome membrane assembly and magnetite biomineralization.
Plitzko JM, Schüler D, Zarivach R
Mol Microbiol. 2018 Feb;107(4):542-557.
DOI: 10.1111/mmi.13899. | PUBMED: 29243866. | IF(2018) = 3.6
PDB [P13]: 5HOK

173: Crystal structure correlations with the intrinsic thermodynamics of humancarbonic anhydrase inhibitor binding.
Smirnov A, Zubriene A, Manakova E, Grazulis S, Matulis D,
PeerJ. 2018 Feb 26;6:e4412. eCollection 2018.
DOI: 10.7717/PEERJ.4412 | PUBMED: 29503769
PDB [P14]: 5LLP 5MSB 5LLO 5LLG 5LLC 5OGO

172: Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent-Exposed Ribose-33 Pocket of tRNA-Guanine Transglycosylase.
Movsisyan LD, Schafer E, Nguyen A, Ehrmann FR, Schwab A, Rossolini T, Zimmerli D, Wagner B, Daff H, Heine A, Klebe G, Diederich F,
Chemistry. 2018 Jul 11;24(39):9957-9967.
DOI: 10.1002/chem.201801756 | PUBMED: 29939431 | IF(2019) = 4.9
PDB [P14]: 5JSW 5JSV

171: Crystal structure of a novel domain of the motor subunit of the Type I restriction enzyme EcoR124 involved in complex assembly and DNA binding.
Grinkevich P, Sinha D, Iermak I, Guzanova A, Weiserova M, Ludwig J, Mesters JR, Ettrich RH.
J Biol Chem. 2018 Sep 28;293(39):15043-15054.
DOI: 10.1074/jbc.RA118.003978. Epub 2018 Jul 27. | PUBMED: 30054276 | IF(2018) = 4.1
PDB [P13]: 5J3N

Number of publications for 2018: 50

2017

170: Molecular basis of the 14-3-3 protein-dependent activation of yeast neutraltrehalase Nth1.
Alblova M, Smidova A, Docekal V, Vesely J, Herman P, Obsilova V, Obsil T,
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9811-E9820. Epub 2017 Oct 30.
DOI: 10.1073/PNAS.1714491114 | PUBMED: 29087344 | IF(2019) = 9.4
PDB [P13]: 5JTA

169: Urease Inhibition in the Presence of N-(n-Butyl)thiophosphoric Triamide, aSuicide Substrate: Structure and Kinetics.
Mazzei L, Cianci M, Contaldo U, Musiani F, Ciurli S
Biochemistry. 2017 Oct 10;56(40):5391-5404. Epub 2017 Sep 15.
DOI: 10.1021/ACS.BIOCHEM.7B00750 | PUBMED: 28857549 | IF(2018) = 3.0
PDB [P13]: 5OL4

168: PROTEIN CRYSTALS IR LASER ABLATED FROM AQUEOUS SOLUTION AT HIGH SPEED RETAIN THEIR DIFFRACTIVE PROPERTIES: APPLICATIONS IN HIGH-SPEED SERIAL CRYSTALLOGRAPHY.
E.C.SCHULZ,J.KAUB,F.BUSSE,P.MEHRABI,H.M.MULLER-WERKMEISTER, E.F.PAI,W.D.ROBERTSON,R.J.D.MILLER
J Appl Crystallogr. 50:1773 2017
DOI: 10.1107/S1600576717014479 | PUBMED:
PDB [P14]: 5NYV 5O2G

167: Crystal structure of a marine glycoside hydrolase family 99-related proteinlacking catalytic machinery.
Robb CS, Mystkowska AA, Hehemann JH
Protein Sci. 2017 Dec;26(12):2445-2450. Epub 2017 Nov 21.
DOI: 10.1002/PRO.3291 | PUBMED: 28884852 | IF(2018) = 2.4
PDB [P13]: 5NGW

166: Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of ProteinKinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2alpha andIts Paralog CK2alpha'.
Hochscherf J, Lindenblatt D, Witulski B, Birus R, Aichele D, Marminon C, Bouaziz Z, Le Borgne M, Jose J, Niefind K
Pharmaceuticals (Basel). 2017 Dec 13;10(4).
DOI: 10.3390/PH10040098 | PUBMED: 29236079
PDB [P13]: 5OOI

165: Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic.
Samygina VR, Sokolov AV, Bourenkov G, Schneider TR, Anashkin VA, Kozlov SO, Kolmakov NN, Vasilyev VB,
Metallomics. 2017 Dec 1;9(12):1828-1838. Epub 2017 Nov27.
DOI: 10.1039/C7MT00157F | PUBMED: 29177316
PDB [P14]: 5N4L 5N2K

164: A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site.
Mamais M, Degli Esposti A, Kouloumoundra V, Gustavsson T, Monti F, Venturini A, Chrysina ED, Markovitsi D, Gimisis T
Chemistry. 2017 Jul 3;23(37):8800-8805 Epub 2017Jun 19.
DOI: 10.1002/CHEM.201701591 | PUBMED: 28493496 | IF(2019) = 4.9
PDB [P14]: 5MEM

163: Crystal structure and catalytic characterization of the dehydrogenase/reductaseSDR family member 4 (DHRS4) from Caenorhabditis elegans.
Kisiela M, Faust A, Ebert B, Maser E, Scheidig AJ,
FEBS J. 2017 Nov 19.
DOI: 10.1111/FEBS.14337 | PUBMED: 29151266 | IF(2018) = 4.7
PDB [P14]: 5OJG 5OJI

162: Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a uniquedimeric structure.
Perveen S, Rashid N, Tang XF, Imanaka T, Papageorgiou AC
FEBS Open Bio. 2017 Jul 24;7(8):1217-1230.
DOI: 10.1002/2211-5463.12264 | PUBMED: 28781961
PDB [P13]: 5NOF

161: Crystal structures of serum albumins from domesticated ruminants and theircomplexes with 3,5-diiodosalicylic acid.
Bujacz A, Talaj JA, Zielinski K, Pietrzyk-Brzezinska AJ, Neumann P,
Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):896-909.
DOI: 10.1107/S205979831701470X | PUBMED: 29095162 | IF(2018) = 3.2
PDB [P13]: 5ORF

160: Crystal structure of the Legionella pneumophila Lpg2936 in complex with thecofactor S-adenosyl-L-methionine reveals novel insights into the mechanism ofRsmE family methyltransferases.
Pinotsis N, Waksman G,
Protein Sci. 2017 Sep 22.
DOI: 10.1002/PRO.3305 | PUBMED: 28940762 | IF(2018) = 2.4
PDB [P13]: 5O96

159: Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction.
Stranava M, Man P, Skálová T, Kolenko P, Blaha J, Fojtikova V, Martínek V, Dohnálek J, Lengalova A, Rosůlek M, Shimizu T, Martínková M
J Biol Chem. 2017 Dec 22;292(51):20921-20935.
DOI: 10.1074/jbc.M117.817023. Epub 2017 Nov 1. | PUBMED: 29092908 | IF(2018) = 4.1
PDB [P13]: 5OHF

158: Dynamic control of RSK complexes by phosphoswitch-based regulation.
Gogl G, Biri-Kovacs B, Poti AL, Vadaszi H, Szeder B, Bodor A, Schlosser G, Acs A, Turiak L, Buday L, Alexa A, Nyitray L, Remenyi A,
FEBS J. 2017 Oct 30.
DOI: 10.1111/FEBS.14311 | PUBMED: 29083550 | IF(2018) = 4.7
PDB [P14]: 5N7D

157: Structural Basis of the Selectivity of GenN, an AminoglycosideN-Methyltransferase Involved in Gentamicin Biosynthesis.
Bury PDS, Huang F, Li S, Sun Y, Leadlay PF, Dias MVB
ACS Chem Biol. 2017 Oct 9.
DOI: 10.1021/ACSCHEMBIO.7B00466 | PUBMED: 28876898 | IF(2019) = 4.43
PDB [P13]: 5TYQ 5U4T 5U19

156: Mechanism of RNA polymerase II stalling by DNA alkylation
Malvezzi S, Farnung L, Aloisi CMN, Angelov T, Cramer P, Sturla SJ
Proc Natl Acad Sci U S A. 2017 Oct 30.
DOI: 10.1073/PNAS.1706592114 | PUBMED: 29087308 | IF(2019) = 9.4
PDB [P13]: 5OT2

155: UbaLAI is a monomeric Type IIE restriction enzyme.
Sasnauskas G, Tamulaitiene G, Tamulaitis G, Calyseva J, Laime M, Rimseliene R, Lubys A, Siksnys V,
Nucleic Acids Res. 2017 Sep 19;45(16):9583-9594.
DOI: 10.1093/NAR/GKX634 | PUBMED: 28934493 | IF(2018) = 11.1
PDB [P13]: 5O63

154: Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Hansen SB, Laursen NS, Andersen GR, Andersen KR,
Acta Crystallogr D Struct Biol. 2017 Oct 1;73(Pt 10):804-813. Epub 2017 Sep 27.
DOI: 10.1107/S2059798317013171 | PUBMED: 28994409 | IF(2018) = 3.2
PDB [P13]: 5NM0 5NML

153: Lysozyme's lectin-like characteristics facilitates its immune defense function
Zhang R, Wu L, Eckert T, Burg-Roderfeld M, Rojas-Macias MA, Lüttek T, Krylov VB, Argunov DA, Datta A, Markart P, Guenther, A.; Norden, B.; Schauer, R.; Bhunia, A.; Enani, M. A.; Billeter, M.; Scheidig, A. J.; Nifantiev, N. E.; Siebert, H.-C.
Q Rev Biophys. 2017, 50.
DOI: 10.1017/S0033583517000075 | PUBMED: 29233221 | IF(2018) = 6.6
PDB [P13]: 5LSH

152: Mechanistic insights into cyclic peptide generation by DnaE split-inteins throughquantitative and structural investigation.
Kick L, Harteis S, Koch MF, Schneider S,
ChemBioChem. 2017 Sep 15.
DOI: 10.1002/CBIC.201700503 | PUBMED: 28914478 | IF(2018) = 2.6
PDB [P14]: 5OL5

151: The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery.
Prevost MS, Pinotsis N, Dumoux M, Hayward RD, Waksman G,
Sci Rep. 2017 Aug 25;7(1):9450.
DOI: 10.1038/S41598-017-10249-6 | PUBMED: 28842705 | IF(2018) = 4.1
PDB [P13]: 5NNY

150: Structures of designed armadillo repeat proteins binding to peptides fused toglobular domains.
Hansen S, Kiefer JD, Madhurantakam C, Mittl PRE, Pluckthun A,
Protein Sci. 2017 Jul 10
DOI: 10.1002/PRO.3229 | PUBMED: 28691351 | IF(2018) = 2.4
PDB [P14]: 5MFD

149: Mechanism of Transcription Anti-termination in Human Mitochondria.
Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D,
Cell. 2017 Oct 7.
DOI: 10.1016/J.CELL.2017.09.035 | PUBMED: 29033127 | IF(2018) = 36.2
PDB [P13]: 5OL9

148: Structural Basis for Mitotic Centrosome Assembly in Flies.
Feng Z, Caballe A, Wainman A, Johnson S, Haensele AFM, Cottee MA, Conduit PT, Lea SM, Raff JW,
Cell. 2017 Jun 1;169(6):1078-1089.e13.
DOI: 10.1016/J.CELL.2017.05.030 | PUBMED: 28575671 | IF(2018) = 36.2
PDB [P13]: 5MW9 5MW0

147: Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases
E.CAPKAUSKAITE,V.LINKUVIENE,A.SMIRNOV,G.MILINAVICIUTE,D.TIMM,A.KASILIAUSKAITE,E.MANAKOVA,S.GRAZULIS,D.MATULIS
Chemistry Select 2017 2:5360-5371
DOI: 10.1002/SLCT.201700531 | PUBMED:
PDB [P13]: 5LL4 5LL5 5LL9 5LLA

146: Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and KainateReceptors.
Mollerud S, Pinto A, Marconi L, Frydenvang K, Thorsen TS, Laulumaa S, Venskutonyte R, Winther S, Moral AMC, Tamborini L, Conti P, Pickering DS, Kastrup JS
ACS Chem Neurosci. 2017 Jul 21.
DOI: 10.1021/ACSCHEMNEURO.7B00201 | PUBMED: 28691798 | IF(2019) = 4.5
PDB [P14]: 5NEB

145: Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhard V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M, Schwalbe H, Kuster B, Medard G,
ChemMedChem. 2017 May 24.
DOI: 10.1002/CMDC.201700217 | PUBMED: 28544567 | IF(2018) = 3.0
PDB [P13]: 5NKA 5NKB 5NKC 5NKD 5NK6 5NK8 5NK9

144: Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by stericshielding and substrate fixation.
Newie J, Neumann P, Werner M, Mata RA, Ficner R, Feussner I
Sci Rep. 2017 May 18;7(1):2069.
DOI: 10.1038/S41598-017-02153-W | PUBMED: 28522865 | IF(2018) = 4.1
PDB [P14]: 5MEG

143: Structure of a soluble epoxide hydrolase identified in Trichoderma reesei.
Wilson C, De Oliveira GS, Adriani PP, Chambergo FS, Dias MVB,
Biochim Biophys Acta. 2017 May 11.
DOI: 10.1016/J.BBAPAP.2017.05.004 | PUBMED: 28502798
PDB [P13]: 5URO

142: Trapped intermediate state of plant pyruvate phosphate dikinase indicatessubsteps in catalytic swiveling domain mechanism.
Minges A, Hoppner A, Groth G,
Protein Sci. 2017 May 3.
DOI: 10.1002/PRO.3184 | PUBMED: 28470715 | IF(2018) = 2.4
PDB [P13]: 5LU4

141: Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and2-Aminopyridine Become Protonated Upon Binding to Trypsin.
Schiebel J, Gaspari R, Sandner A, Ngo K, Gerber HD, Cavalli A, Ostermann A, Heine A, Klebe G
Angew Chem Int Ed Engl. 2017 Apr 18;56(17):4887-4890. Epub 2017 Mar 28.
DOI: 10.1002/ANIE.201701038 | PUBMED: 28371253 | IF(2019) = 13.0
PDB [P14]: 5MN1 5MNC 5MNB 5MON

140: Core Mediator structure at 3.4 A extends model of transcription initiationcomplex.
Nozawa K, Schneider TR, Cramer P,
Nature. 2017 May 11;545(7653):248-251.
DOI: 10.1038/NATURE22328 | PUBMED: 28467824 | IF(2018) = 43.1
PDB [P14]: 5N9J

139: EXPLAINING OPERATIONAL INSTABILITY OF AMINE TRANSAMINASES: SUBSTRATE-INDUCED INACTIVATION MECHANISM AND INFLUENCE OF QUATERNARY STRUCTURE ON ENZYME-COFACTOR INTERMEDIATE STABILITY.
T.BORNER,S.RAMISCH,E.REDDEM,S.BARTSCH,A.VOGEL, A.M.W.H.THUNNISSEN,P.ADLERCREUTZ,C.GREY
ACS Catalysis. 7:1259-1269 (2017)
DOI: 10.1021/ACSCATAL.6B02100 | PUBMED: | IF(2018) = 12.1
PDB [P14]: 5LH9

138: Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Mickeviciute A, Timm DD, Gedgaudas M, Linkuviene V, Chen Z, Waheed A, Michailoviene V, Zubriene A, Smirnov A, Capkauskaite E, Baranauskiene L, Jachno J, Revuckiene J, Manakova E, Grazulis S, Matuliene J, Di Cera E, Sly WS, Matulis D, ORCID: http://orcid.org/0000-0002-6178-6276,
Eur Biophys J. 2017 Oct 3.
DOI: 10.1007/S00249-017-1256-0 | PUBMED: 28975383
PDB [P14]: 5IPZ

137: Structure of the WipA protein reveals a novel tyrosine protein phosphataseeffector from Legionella pneumophila.
Pinotsis N, Waksman G
J Biol Chem. 2017 Jun 2;292(22):9240-9251. Epub2017 Apr 7.
DOI: 10.1074/JBC.M117.781948 | PUBMED: 28389563 | IF(2018) = 4.1
PDB [P13]: 5N6X

136: Manszewski T, Szpotkowski K, Jaskolski M.
Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii.
IUCrJ. 2017 Apr 10;4(Pt 3):271-282. eCollection 2017 May 1.
DOI: 10.1107/S2052252517002433 | PUBMED: 28512574 | IF(2020) = 4
PDB [P13]: 5M67 5M5K

135: Structural insights into reptarenavirus cap- snatching machinery
Rosenthal, M., Gogrefe, N., Vogel, D., Reguera, J., Rauschenberger, B., Cusack, S., Günther, S. & Reindl, S
PLoS Pathog. (2017) 13, e1006400-1006424.
DOI: 10.1371/journal.ppat.1006400 | PUBMED: 28505175 | IF(2018) = 6.1
PDB [P13]: 5MUZ 5MV0

134: Crystal structure and biological implications of a glycoside hydrolase family 55 beta-1,3-glucanase from Chaetomium thermophilum.
Papageorgiou AC, Chen J, Li D,
Biochim Biophys Acta. 2017 May 4.
DOI: 10.1016/J.BBAPAP.2017.05.002 | PUBMED: 28479293
PDB [P13]: 5M60

133: Structural and functional innovations in the real-time evolution of new(betaalpha)8 barrel enzymes.
Newton MS, Guo X, Soderholm A, Nasvall J, Lundstrom P, Andersson DI, Selmer M, Patrick WM
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4727-4732. Epub 2017 Apr 17.
DOI: 10.1073/PNAS.1618552114 | PUBMED: 28416687 | IF(2019) = 9.4
PDB [P14]: 5L6U

132: Functional and structural insight into properdin control of complement alternative pathway amplification.
Pedersen DV, Roumenina L, Jensen RK, Gadeberg TA, Marinozzi C, Picard C, Rybkine T, Thiel S, Sørensen UB, Stover C, Fremeaux-Bacchi V, Andersen GR.
EMBO J. 2017 Apr 13;36(8):1084-1099.
DOI: 10.15252/embj.201696173. Epub 2017 Mar 6. | PUBMED: 28264884 | IF(2018) = 11.2
PDB [P14]: PDB:

131: Structural insights into the mechanism of the DEAH-box RNA helicase Prp43.
FTauchert MJ, Fourmann JB, Luhrmann R, Ficner R
Elife. 2017 Jan 16;6.
DOI: 10.7554/ELIFE.21510 | PUBMED: 28092261 | IF(2016) = 8.3
PDB [P13]: 5LTA 5LTK 5LTJ

130: Structural aspects of nucleotide ligand binding by a bacterial 2Hphosphoesterase.
Myllykoski M, Kursula P,
PLoS One. 2017 Jan 31;12(1):e0170355.
DOI: 10.1371/JOURNAL.PONE.0170355 | PUBMED: 28141848 | IF(2014) = 3.23
PDB [P13]: 5LDQ

129: Inactivation of urease by catechol: Kinetics and structure.
Mazzei L, Cianci M, Musiani F, Lente G, Palombo M, Ciurli S,
J Inorg Biochem. 2017 Jan;166:182-189. Epub2016 Nov 9.
DOI: 10.1016/J.JINORGBIO.2016.11.016 | PUBMED: 27888701
PDB [P13]: 5G4H

128: Evaluating the Contribution of Transition-State Destabilization to Changes in theResidence Time of Triazole-Based InhA Inhibitors.
Spagnuolo LA, Eltschkner S, Yu W, Daryaee F, Davoodi S, Knudson SE, Allen EK, Merino J, Pschibul A, Moree B, Thivalapill N, Truglio JJ, Salafsky J, Slayden RA, Kisker C, Tonge PJ,
J Am Chem Soc. 2017 Feb 22.
DOI: 10.1021/JACS.6B11148 | PUBMED: 28151657 | IF(2015) = 13.0
PDB [P13]: 5MTQ

127: Architecture and mechanism of the late endosomal Rab7-like Ypt7 guaninenucleotide exchange factor complex Mon1-Ccz1.
Kiontke S, Langemeyer L, Kuhlee A, Schuback S, Raunser S, Ungermann C, Kummel D,
Nat Commun. 2017 Jan 4;8:14034.
DOI: 10.1038/NCOMMS14034 | PUBMED: 28051187 | IF(2015) = 11.3
PDB [P13]: 5LDD

126: Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
Peng B, Thorsell AG, Karlberg T, Schuler H, Yao SQ,
Angew Chem Int Ed Engl. 2017 Jan 2;56(1):248-253. Epub 2016 Dec 5.
DOI: 10.1002/ANIE.201609655 | PUBMED: 27918638 | IF(2015) = 11.7
PDB [P13]: 5LYH

125: Collapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, andconformational flexibility.
Myllykoski M, Baumann A, Hensley K, Kursula P
Amino Acids. 2017 Jan 2.
DOI: 10.1007/S00726-016-2376-Z | PUBMED: 28044206 | IF(2016) = 3.2
PDB [P13]: 5LXX

124: Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to
Zubriene A, Smirnov A, Dudutiene V, Timm DD, Matuliene J, Michailoviene V, Zakšauskas A, Manakova E, Gražulis S, Matulis D
Carbonic Anhydrases. ChemMedChem. 2017 Jan 20;12(2):161-176.
DOI: 10.1002/cmdc.201600509. Epub 2016 Dec 21. | PUBMED: 28001003.
PDB [P14]: 5E2M 5E2N 5DRS 5DOH

123: Glucose-1-phosphate uridylyltransferase from Erwinia amylovora: Activity, structure and substrate specificity.
Benini S, Toccafondi M, Rejzek M, Musiani F, Wagstaff BA, Wuerges J, Cianci M, Field RA.
Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt A):1348-1357.
DOI: 10.1016/j.bbapap.2017.08.015. Epub 2017 Aug 24. | PUBMED: 28844747.
PDB [P13]: 4D48

Number of publications for 2017: 48

2016

122: Structural Analysis of beta-Fructofuranosidase from Xanthophyllomyces dendrorhousReveals Unique Features and the Crucial Role of N-Glycosylation inOligomerization and Activity.
Ramirez-Escudero M, Gimeno-Perez M, Gonzalez B, Linde D, Merdzo Z, Fernandez-Lobato M, Sanz-Aparicio J,
J Biol Chem. 2016 Mar 25;291(13):6843-57. Epub 2016Jan 28.
DOI: 10.1074/JBC.M115.708495 | PUBMED: 26823463 | IF(2018) = 4.1
PDB [P13]: 5FKB 5FMB 5FKC

121: Ferrocene-Biotin Conjugates: Synthesis, Structure, Cytotoxic Activity and Interaction with Avidin
Blauz, A., Rychlik, B., Makal, A., Szulc, K., Strzelczyk, P., Bujacz, G., Zakrzewski, J., Wozniak, K., Plazuk, D.
Chempluschem 81: 1191-1201 (2016)
DOI: 10.1002/cplu.201600320 | PUBMED:
PDB [P13]: 5HLM

120: Structural and Catalytic Properties of S1 Nuclease from Aspergillus oryzae Responsible for Substrate Recognition, Cleavage, Non-Specificity, and Inhibition.
Koval T, Ostergaard LH, Lehmbeck J, Norgaard A, Lipovova P, Duskova J, Skalova T, Trundova M, Kolenko P, Fejfarova K, Stransky J, Svecova L, Hasek J, Dohnalek J,
PLoS One. 2016 Dec 30;11(12):e0168832. eCollection 2016.
DOI: 10.1371/JOURNAL.PONE.0168832 | PUBMED: 28036383 | IF(2018) = 2.8
PDB [P13]: 5FB9

119: First Structure-Activity Relationship of 17beta-Hydroxysteroid Dehydrogenase Type14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.
Braun F, Bertoletti N, Moller G, Adamski J, Steinmetzer T, Salah M, Abdelsamie AS, van Koppen CJ, Heine A, Klebe G, Marchais-Oberwinkler S,
J Med Chem. 2016 Dec 8;59(23):10719-10737. Epub 2016 Nov 18.
DOI: 10.1021/ACS.JMEDCHEM.6B01436 | PUBMED: 27933965 | IF(2014) = 5.4
PDB [P13]: 5L7T 5L7Y

118: Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNAhelicase Brr2.
Absmeier E, Becke C, Wollenhaupt J, Santos KF, Wahl MC,
Cell Cycle. 2016 Nov 23:1-13.
DOI: 10.1080/15384101.2016.1255384 | PUBMED: 27880071
PDB [P13]: 5M59

117: Structural basis of myelin-associated glycoprotein adhesion and signalling.
Pronker MF, Lemstra S, Snijder J, Heck AJ, Thies-Weesie DM, Pasterkamp RJ, Janssen BJ
Nat Commun. 2016 Dec 6;7:13584.
DOI: 10.1038/NCOMMS13584 | PUBMED: 27922006 | IF(2022) = 14.9
PDB [P14]: 5LFU

116: Structural Characterization of the Avidin Interactions with Fluorescent Pyrene-Conjugates: 1-Biotinylpyrene and 1-Desthiobiotinylpyrene.
Strzelczyk P, Plazuk D, Zakrzewski J, Bujacz G
Molecules. 2016 Sep 27;21(10).
DOI: 10.3390/MOLECULES21101270 | PUBMED: 27689976 | IF(2015) = 2.5
PDB [P13]: 5IRU 5IRW

115: Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance.
Barber-Zucker S, Uebe R, Davidov G, Navon Y, Sherf D, Chill JH, Kass I, Bitton R, Schuler D, Zarivach R
Sci Rep. 2016 Aug 23;6:31933.
DOI: 10.1038/SREP31933 | PUBMED: 27550551 | IF(2015) = 5.2
PDB [P13]: 5HSP

114: Structural and functional characterization of a ruminal beta-glycosidase defines a novel subfamily of glycosyl hydrolase family 3 with permuted domain topology.
Ramirez-Escudero M, Del Pozo MV, Marin-Navarro J, Gonzalez B, Golyshin PN, Polaina J, Ferrer M, Sanz-Aparicio J
J Biol Chem. 2016 Sep 27.
DOI: 10.1074/JBC.M116.747527 | PUBMED: 27679487 | IF(2014) = 4.57
PDB [P13]: 5K6M

113: A multicrystal diffraction data-collection approach for studying structural dynamics with millisecond temporal resolution.
Schubert R, Kapis S, Gicquel Y, Bourenkov G, Schneider TR, Heymann M, Betzel C, Perbandt M
IUCrJ. 2016 Oct 26;3(Pt 6):393-401. eCollection 2016 Nov 1.
DOI: 10.1107/S2052252516016304 | PUBMED: 27840678 | IF(2016) = 5.31
PDB [P14]: 5EN4 5M62 5LH7 5EUV 5C9O 5C9L 5LMH 5LN0 5JXQ 5LH6 5LH5 5LH3 5LH1 5LH0 5F5V 5A62 5D4W 5F5T

112: Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs.
Heinzlmeir S, Kudlinzki D, Sreeramulu S, Klaeger S, Gande SL, Linhard V, Wilhelm M, Qiao H, Helm D, Ruprecht B, Saxena K, Medard G, Schwalbe H, Kuster B,
ACS Chem Biol. 2016 Oct 21.
DOI: 10.1021/ACSCHEMBIO.6B00709 | PUBMED: 27768280 | IF(2014) = 5.3
PDB [P13]: 5IA4 5I9W 5I9Y 5I9X 5I9Z 5IA5 5IA1 5I9V

111: The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Dahms SO, Creemers JW, Schaub Y, Bourenkov GP, Zogg T, Brandstetter H, Than ME
Sci Rep. 2016 Sep 27;6:34303.
DOI: 10.1038/SREP34303 | PUBMED: 27670069 | IF(2015) = 5.23
PDB [P13]: 5JMO

110: Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptorGIF.
Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN
Nat Commun. 2016 Nov 7;7:13228.
DOI: 10.1038/NCOMMS13228 | PUBMED: 27819269 | IF(2015) = 11.3
PDB [P14]: 5D22 5D28

109: Robotic QM/MM-driven maturation of antibody combining sites.
Smirnov IV, Golovin AV, Chatziefthimiou SD, Stepanova AV, Peng Y, Zolotareva OI, Belogurov AA Jr, Kurkova IN, Ponomarenko NA, Wilmanns M, Blackburn GM, Gabibov AG, Lerner RA
Sci Adv. 2016 Oct 19;2(10):e1501695. eCollection 2016 Oct.
DOI: 10.1126/SCIADV.1501695 | PUBMED: 27774510 | IF(2018) = 12.5
PDB [P14]: 5TJD 6Y1N 5ADO

108: HU histone-like DNA-binding protein from Thermus thermophilus: structural andevolutionary analyses.
Papageorgiou AC, Adam PS, Stavros P, Nounesis G, Meijers R, Petratos K, Vorgias CE
Extremophiles. 2016 Jun 24.
DOI: 10.1007/S00792-016-0859-1 | PUBMED: 27342116 | IF(2014) = 2.34
PDB [P14]: 5EKA

107: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
Schrader J, Henneberg F, Mata RA, Tittmann K, Schneider TR, Stark H, Bourenkov G, Chari A
Science. 2016 Aug 5;353(6299):594-8.
DOI: 10.1126/SCIENCE.AAF8993 | PUBMED: 27493187 | IF(2015) = 34.6
PDB [P14]: 5LE5 5LF1 5LF0 5LF3 5LF4 5LF6 5LF7 5LEX 5LEY 5LEZ

106: Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.
Kasaragod VB, Schindelin H,
Structure. 2016 May 3;24(5):782-8. Epub 2016 Apr 21.
DOI: 10.1016/J.STR.2016.02.023 | PUBMED: 27112598 | IF(2014) = 5.62
PDB [P13]: 5ERV 5ERU

105: Data collection with a tailored X-ray beam size at 2.69 A wavelength (4.6 keV):sulfur SAD phasing of Cdc23(Nterm).
Cianci M, Groves MR, Barford D, Schneider TR,
Acta Crystallogr D Struct Biol. 2016 Mar 1;72(Pt 3):403-12. Epub 2016 Mar 1.
DOI: 10.1016/j.ijbiomac.2016.02.047 | PUBMED: 26960127 | IF(2015) = 2.51
PDB [P13]: 5FTP

104: Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase.
Clausen JD, Bublitz M, Arnou B, Olesen C, Andersen JP, Moller JV, Nissen P,
Structure. 2016 Apr 5;24(4):617-23.
DOI: 10.1016/J.STR.2016.02.018 | PUBMED: 27050689 | IF(2014) = 5.62
PDB [P14]: 5A3Q

103: Molecular basis for inhibition of AcrB multidrug efflux pump by novel andpowerful pyranopyridine derivatives.
Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS, Ding X, Ornik AR, Ruggerone P, Bowlin TL, Nikaido H, Pos KM, Opperman TJ,
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3509-14. Epub 2016 Mar 14.
DOI: 10.1073/PNAS.1602472113 | PUBMED: 26976576 | IF(2015) = 9.74
PDB [P13]: 5ENT

102: Inactivation of urease by 1,4-benzoquinone: chemistry at the protein surface.
Mazzei L, Cianci M, Musiani F, Ciurli S,
Dalton T. 2016 Apr 7;45(13):5455-9. Epub 2016 Mar10.
DOI: 10.1039/C6DT00652C | PUBMED: 26961812 | IF(2015) = 4.19
PDB [P13]: 5FSE 5FSD

101: Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases.
Molitor C, Mauracher SG, Rompel A
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1806-15. Epub 2016 Mar 14.
DOI: 10.1073/PNAS.1523575113 | PUBMED: 26976571 | IF(2015) = 9.74
PDB [P14]: 4Z0Y

100: Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.
Drebes J, Kunz M, Windshugel B, Kikhney AG, Muller IB, Eberle RJ, Oberthur D, Cang H, Svergun DI, Perbandt M, Betzel C, Wrenger C
Sci Rep. 2016 Mar 10;6:22871.
DOI: 10.1038/SREP22871 | PUBMED: 26960569 | IF(2014) = 5.57
PDB [P14]: 5CGA 5CGE

99: Crystallographic studies of the complex of human HINT1 protein with anon-hydrolyzable analog of Ap4A.
Dolot R, Kaczmarek R, Seda A, Krakowiak A, Baraniak J, Nawrot B
Int J Biol Macromol. 2016 Jun;87:62-9. Epub 2016 Feb 18.
DOI: 10.1016/J.IJBIOMAC.2016.02.047 | PUBMED: 26905466 | IF(2018) = 4.8
PDB [P13]: 4ZKL

98: Sleeping Beauty transposase structure allows rational design of hyperactivevariants for genetic engineering.
Voigt F, Wiedemann L, Zuliani C, Querques I, Sebe A, Mates L, Izsvak Z, Ivics Z, Barabas O,
Nat Commun. 2016 Mar 30;7:11126.
DOI: 10.1038/NCOMMS11126 | PUBMED: 27025571 | IF(2014) = 11.4
PDB [P14]: 5CR4

97: Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells.
Berneking L, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney AG, Koch-Nolte F, Buck F, Perbandt M, Betzel C, Svergun DI, Hentschke M, Aepfelbacher M,
PLoS Pathog. 2016 Jun 14;12(6):e1005660. eCollection 2016 Jun.
DOI: 10.1371/journal.ppat.1005660 | PUBMED: 27300509 | IF(2018) = 6.1
PDB [P14]: 4OW2

96: Impact of the crystallization condition on importin-β conformation. Acta Crystallogr D
Tauchert MJ, Hémonnot C, Neumann P, Köster S, Ficner R, Dickmanns A
Struct Biol. 2016 Jun;72(Pt 6):705-17.
DOI: 10.1107/S2059798316004940 | PUBMED: 27303791
PDB [P13]: 4XRI 4XRK

95: Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangementfor phosphoryl transfer.
Weisse RH, Faust A, Schmidt M, Schonheit P, Scheidig AJ
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E519-28. Epub 2016 Jan 19.
DOI: 10.1073/PNAS.1518614113 | PUBMED: 26787904 | IF(2014) = 9.67
PDB [P14]: 5HBR 4YAK 4XYL 4YB8 4YBZ 4XYM

94: Comprehensive Structural Characterization of the Bacterial HomospermidineSynthase-an Essential Enzyme of the Polyamine Metabolism.
Krossa S, Faust A, Ober D, Scheidig AJ,
Sci Rep. 2016 Jan 18;6:19501.
DOI: 10.1038/SREP19501 | PUBMED: 26776105 | IF(2014) = 5.6
PDB [P14]: 4TVB 4XRG 4XR4 4XQC 4XQE 4XQG

93: Characterization and 1.57 A resolution structure of the key fire blight phosphatase AmsI from Erwinia amylovora.
Salomone-Stagni M, Musiani F, Benini S.
Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):903-910. Epub 2016 Nov 30.
DOI: 10.1107/S2053230X16018781 | PUBMED: 27917839; | IF(2019) = 0.97
PDB [P13]: 4D74

92: Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants
Stellmacher L, Sandalova T, Schneider S, Schneider G, Sprenger GA, Samland AK
Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):467-76.
DOI: 10.1107/S2059798316001170. Epub 2016 Mar 24. | PUBMED: 27050126 | IF(2018) = 3.2
PDB [P13]: 4S2B

91: Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris.
Rudolph K, Parthier C, Egerer-Sieber C, Geiger D, Muller YA, Kreis W, Muller-Uri F
Acta Crystallogr F Struct Biol Commun. 2016 Jan 1;72(Pt 1):16-23.
DOI: 10.1107/S2053230X15023043 | PUBMED: 26750479 | IF(2014) = 0.54
PDB [P13]: 5C05

Number of publications for 2016: 32

2015

90: Structure of GPN-loop GTPase Npa3 and implications for RNA polymerase II assembly.
Niesser J,Wagner FR,Kostrewa D,Muhlbacher W,Cramer P
Mol Cell Biol. 2015 Dec 28.
DOI: 10.1128/MCB.01009-15 | PUBMED: 26711263 | IF(2015) = 4.77
PDB [P13]: 5HCN 5HCI

89: The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs.
Kiliszek A, Banaszak K, Dauter Z, Rypniewski W
Nucleic Acids Res. 2015 Dec 29.
DOI: 10.1093/NAR/GKV1513 | PUBMED: 26717983 | IF(2015) = 9.12
PDB [P13]: 5EMF

88: Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/IronCofactor.
Griese JJ, Kositzki R, Schrapers P, Branca RM, Nordstrom A, Lehtio J, Haumann M, Hogbom M
J Biol Chem. 2015 Oct 16;290(42):25254-72. Epub2015 Aug 31.
DOI: 10.1016/J.JINORGBIO.2016.04.019 | PUBMED: 26324712 | IF(2014) = 4.57
PDB [P13]: 5EKB

87: The terminal phycobilisome emitter, LCM: A light-harvesting pigment with aphytochrome chromophore.
Tang K, Ding WL, Hoppner A, Zhao C, Zhang L, Hontani Y, Kennis JT, Gartner W, Scheer H, Zhou M, Zhao KH
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15880-5.
DOI: 10.1073/PNAS.1519177113 | PUBMED: 26669441 | IF(2014) = 9.67
PDB [P13]: 4XXI

86: The large N-terminal region of the Brr2 RNA helicase guides productivespliceosome activation.
Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Preussner M, Heyd F, Urlaub H, Luhrmann R, Santos KF, Wahl MC
Gene Dev. 2015 Dec 15;29(24):2576-87. Epub 2015 Dec4.
DOI: 10.1101/GAD.271528.115 | PUBMED: 26637280 | IF(2014) = 12.6
PDB [P14]: 5DCA

85: Structural Insights into the Competitive Binding of Diclofenac and Naproxen by Equine Serum Albumin.
Sekula B, Bujacz A
J Med Chem. 2015 Dec 23.
DOI: 10.1021/ACS.JMEDCHEM.5B00909 | PUBMED: 26652101 | IF(2014) = 5.4
PDB [P13]: 4ZBQ

84: Structures of yeast peroxisomal Delta(3),Delta(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.
Onwukwe GU, Koski MK, Pihko P, Schmitz W, Wierenga RK
Acta Crystallogr D Biol Crystallogr. 2015 Nov 1;71(Pt 11):2178-91.
DOI: 10.1107/S139900471501559X | PUBMED: 26527136 | IF(2018) = 3.2
PDB [P13]: 4ZDE 4ZDB

83: Terahertz radiation induces non-thermal structural changes associated with Fröhlich condensation in a protein crystal.
Lundholm IV, Rodilla H, Wahlgren WY, Duelli A, Bourenkov G, Vukusic J, Friedman R, Stake J, Schneider T, Katona G.
Struct Dyn (2015 Sep)2:054702
DOI: 10.1063/1.4931825 | PUBMED: 26798828
PDB [P14]: 5APC 5APE 5APD 5APF

82: DETERMINANTS OF LIGAND BINDING AND ACTIVITY IN CNPASE
A.RAASAKKA,M.MYLLYKOSKI,M.LEHTIMAKI,P.KURSULA
Sci Rep. 2015 Nov 13;5:16520.
DOI: 10.1038/srep16520 | PUBMED: 26563764 | IF(2014) = 5.6
PDB [P14]: 4WC9 4WDH 4WEX 4WDF 4WDG 4WDA 4WDB 4WBL

81: Kinetic and structural studies reveal a unique binding mode of sulfite to thenickel center in urease.
Mazzei L,Cianci M,Benini S,Bertini L,Musiani F,Ciurli S
J Inorg Biochem. 2015 Nov 5;154:42-49.
DOI: 10.1016/J.JINORGBIO.2015.11.003 | PUBMED: 26580226
PDB [P13]: 5A6T

80: Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of NaturalPolyphenols and their Metabolites.
Florio P, Folli C, Cianci M,Del Rio D,Zanotti G,Berni R
J Biol Chem. 2015 Oct 14.
DOI: 10.1074/JBC.M115.690172 | PUBMED: 26468275 | IF(2018) = 4.1
PDB [P13]: 5AL8 5AKS 5AKT 5AKV

79: Open and closed states of Candida antarctica Lipase B: protonation and themechanism of interfacial activation.
Stauch B, Fisher SJ, Cianci M
J Lipid Res. 2015 Oct 7.
DOI: 10.1194/JLR.M063388 | PUBMED: 26447231
PDB [P13]: 5A6V 5A71

78: Structural studies of Helix aspersa agglutinin complexed with GalNAc: A lectin that serves as a diagnostic tool.
Pietrzyk AJ, Bujacz A, Mak P, Potempa B, Niedziela T
Int J Biol Macromol. 2015 Sep 28;81:1059-1068.
DOI: 10.1016/J.IJBIOMAC.2015.09.044 | PUBMED: 26416237 | IF(2018) = 4.8
PDB [P13]: 4Q56

77: Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.
Luhavaya H, Dias MV, Williams SR, Hong H, de Oliveira LG, Leadlay PF
Angew Chem Int Ed Engl. 2015 Sep 17.
DOI: 10.1002/ANIE.201507090 | PUBMED: 26377145 | IF(2019) = 13.0
PDB [P13]: 5CXO

76: Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1).
Karna N, Legowska A, Malicki S, Debowski D, Golik P, Gitlin A, Grudnik P, Wladyka B, Brzozowski K, Dubin G, Rolka K
ChemBioChem. 2015 Jul 25.
DOI: 10.1002/CBIC.201500296 | PUBMED: 26212347 | IF(2014) = 3.0
PDB [P13]: 4XOJ

75: Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.
Oberthur D, Achenbach J, Gabdulkhakov A, Buchner K, Maasch C, Falke S, Rehders D, Klussmann S, Betzel C
Nat Commun. 2015 Apr 22;6:6923.
DOI: 10.1038/ncomms7923 | PUBMED: 25901662 | IF(2014) = 11.4
PDB [P13]: 4R8I

74: Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry.
Zubriene A, Smirnoviene J, Smirnov A, Morkunaite V, Michailoviene V, Jachno J, Juozapaitiene V, Norvaisas P, Manakova E, Grazulis S, Matulis D
Biophys Chem. 2015 Oct;205:51-65.
DOI: 10.1016/J.BPC.2015.05.009 | PUBMED: 26079542
PDB [P14]: 4WUP 4WR7 4WW8 4WW6 4WUQ

73: Two independently folding units of Plasmodium profilin suggest evolution via genefusion.
Bhargav SP,Vahokoski J,Kallio JP,Torda AE,Kursula P,Kursula I
Cell Mol Life Sci. 2015 May 27.
DOI: 10.1007/s00018-015-1932-0 | PUBMED: 26012696 | IF(2018) = 7.0
PDB [P13]: 4D60

72: 3-Sulfinopropionyl-coenzyme A (3SP-CoA) desulfinase from Advenellamimigardefordensis DPN7(T): crystal structure and function of a desulfinase with an acyl-CoA dehydrogenase fold.
Schurmann M, Meijers R, Schneider TR, Steinbuchel A, Cianci M
Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1360-72. Epub 2015 May 23.
DOI: 10.1107/S1399004715006616 | PUBMED: 26057676 | IF(2018) = 3.2
PDB [P13]: 5AF7 5AHS

71: High resolution structures of Plasmodium falciparum GST complexes provide novelinsights into the dimer-tetramer transition and a novel ligand-binding site.
Perbandt M,Eberle R,Fischer-Riepe L,Cang H,Liebau E,Betzel C
J Struct Biol. 2015 Sep;191(3):365-75. Epub 2015 Jun 10.
DOI: 10.1016/J.JSB.2015.06.008 | PUBMED: 26072058 | IF(2018) = 3.8
PDB [P14]: 4ZXG

70: Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Simdomain from the Hypoxia-inducible factor 3alpha.
Fala AM, Oliveira JF, Adamoski D, Aricetti JA, Dias MM, Dias MV, Sforca ML, Lopes-de-Oliveira PS, Rocco SA, Caldana C, Dias SM, Ambrosio AL
Sci Rep. 2015 Aug 3;5:12698.
DOI: 10.1038/SREP12698 | PUBMED: 26237540 | IF(2014) = 5.6
PDB [P13]: 4WN5

69: Fragment Binding Can Be Either More Enthalpy-Driven or Entropy-Driven: CrystalStructures and Residual Hydration Patterns Suggest Why.
Ruhmann E, Betz M, Heine A, Klebe G
J Med Chem. 2015 Sep 10;58(17):6960-71. Epub2015 Aug 24.
DOI: 10.1021/ACS.JMEDCHEM.5B00812 | PUBMED: 26270568 | IF(2014) = 5.5
PDB [P14]: 4UDW 5AHG 5AF9 4UD9

68: Functionalization of fluorinated benzenesulfonamides and their inhibitoryproperties toward carbonic anhydrases.
Dudutiene V, Zubriene A, Smirnov A, Timm DD, Smirnoviene J, Kazokaite J, Michailoviene V, Zaksauskas A, Manakova E, Grazulis S, Matulis D
ChemMedChem. 2015 Apr;10(4):662-87.
DOI: 10.1002/CMDC.201402490 | PUBMED: 25758852 | IF(2018) = 3.0
PDB [P13]: 4QIY 4QJ0 4QIZ 4QJP

67: Structural basis of GD2 ganglioside and mimetic peptide recognition by 14G2aantibody.
Horwacik I, Golik P, Grudnik P, Kolinski M, Zdzalik M, Rokita H, Dubin G
Mol Cell Proteomics. 2015 Jul 15.
DOI: 10.1074/mcp.M115.052720 | PUBMED: 26179345 | IF(2018) = 4.8
PDB [P14]: 4TUK 4TUO 4TUL 4TRP

66: Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanningprotein A (DisA) and its inhibition by 3'-dATP.
Muller M, Deimling T, Hopfner KP, Witte G
Biochem J. 2015 Aug 1;469(3):367-74. Epub 2015 May 27.
DOI: 10.1042/BJ20150373 | PUBMED: 26014055
PDB [P14]: 4YVZ

65: Natural flavonoids as antidiabetic agents. The binding of gallic and ellagicacids to glycogen phosphorylase b.
Kyriakis E, Stravodimos GA, Kantsadi AL, Chatzileontiadou DS, Skamnaki VT, Leonidas DD
FEBS Lett. 2015 Jul 8;589(15):1787-94. Epub2015 May 14.
DOI: 10.1016/j.febslet.2015.05.013 | PUBMED: 25980608 | IF(2018) = 2.7
PDB [P14]: 4Z5X

64: Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly.
Male G, von Appen A, Glatt S, Taylor NM, Cristovao M, Groetsch H, Beck M, Muller CW
Nat Commun. 2015 Jun 10;6:7387.
DOI: 10.1038/NCOMMS8387 | PUBMED: 26060179 | IF(2014) = 11.4
PDB [P14]: 5AIO

63: The crystal structure of Erwinia amylovora levansucrase provides a snapshot ofthe products of sucrose hydrolysis trapped into the active site.
Wuerges J, Caputi L, Cianci M, Boivin S, Meijers R, Benini S
J Struct Biol. 2015 Sep;191(3):290-8.
DOI: 10.1016/J.JSB.2015.07.010 | PUBMED: 26208466 | IF(2018) = 3.8
PDB [P13]: 4D47

62: IGG FAB FRAGMENT CRYSTAL FORM 1/2
R.K.JENSEN, G.R.ANDERSEN
Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):419-26
DOI: 10.1107/S2053230X15004100 | PUBMED: 25849503 | IF(2019) = 0.97
PDB [P14]: 4X7T 4X7S

61: A covalent homodimer probing early oligomers along amyloid aggregation.
Halabelian L, Relini A, Barbiroli A, Penco A, Bolognesi M, Ricagno S
Sci Rep. 2015 Sep 30;5:14651.
DOI: 10.1038/srep14651 | PUBMED: 26420657 | IF(2014) = 5.6
PDB [P14]: 4RA3

60: Structural Elucidation of the Bispecificity of A Domains as a Basis forActivating Non-natural Amino Acids.
Kaljunen H, Schiefelbein SH, Stummer D, Kozak S, Meijers R, Christiansen G, Rentmeister A
Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8833-6.
DOI: 10.1002/ANGE.201503275 | PUBMED: 26096082 | IF(2014) = 11.6
PDB [P14]: 4D4I 4D4H 4D4G 4D56 4D57

59: Tracing binding modes in hit-to-lead optimization: chameleon-like poses ofaspartic protease inhibitors.
Kuhnert M, Koster H, Bartholomaus R, Park AY, Shahim A, Heine A, Steuber H, Klebe G, Diederich WE
Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2849-53.
DOI: 10.1002/ANIE.201411206 | PUBMED: 25630461 | IF(2014) = 11.6
PDB [P14]: 3WZ6

58: Structural Hot Spots Determine Functional Diversity of the Candida glabrataEpithelial Adhesin Family.
Diderrich R, Kock M, Maestre-Reyna M, Keller P, Steuber H, Rupp S, Essen LO, Mosch HU
J Biol Chem. 2015 Aug 7;290(32):19597-613.
DOI: 10.1074/jbc.M115.655654 | PUBMED: 26105055 | IF(2018) = 4.1
PDB [P14]: 4COZ 4COW

57: Structure-Based Enzyme Tailoring of 5-Hydroxymethylfurfural Oxidase
Dijkman WP, Binda C, Fraaije MW, Mattevi A
ACS Catalysis. 5: 1833 (2015)
DOI: 10.1021/ACSCATAL.5B00031 | PUBMED: NONE | IF(2018) = 12.1
PDB [P13]: 4UDP

56: Thiosulfate dehydrogenase (TsdA) from Allochromatium vinosum: structural andfunctional insights into thiosulfate oxidation.
Brito JA, Denkmann K, Pereira IA, Archer M, Dahl C
J Biol Chem. 2015 Apr 3;290(14):9222-38.
DOI: 10.1074/JBC.M114.623397 | PUBMED: 25673691 | IF(2018) = 4.1
PDB [P14]: 4WQ8 4WQ9

55: Structural and biochemical analysis of the essential diadenylate cyclase CdaAfrom Listeria monocytogenes.
Rosenberg J, Dickmanns A, Neumann P, Gunka K, Arens J, Kaever V, Stulke J, Ficner R, Commichau FM
J Biol Chem. 2015 Mar 6;290(10):6596-606.
DOI: 10.1074/jbc.M114.630418 | PUBMED: 25605729 | IF(2018) = 4.1
PDB [P13]: 4RV7

54: Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2.
Glatt S, Zabel R, Vonkova I, Kumar A, Netz DJ, Pierik AJ, Rybin V, Lill R, Gavin AC, Balbach J, Breunig KD, Muller CW.
Structure. 2015 Jan 6;23(1):149-60
DOI: 10.1016/J.STR.2014.11.008 | PUBMED: 25543256 | IF(2014) = 6.8
PDB [P14]: 4D4O 4D4P

53: Detailed structure-function correlations of Bacillus subtilis acetolactatesynthase.
Sommer B, von Moeller H, Haack M, Qoura F, Langner C, Bourenkov G, Garbe D, Loll B, Bruck T
ChemBioChem. 2015 Jan 2;16(1):110-8.
DOI: 10.1002/cbic.201402541 | PUBMED: 25393087 | IF(3.1) = 2.6
PDB [P14]: 4RJK

Number of publications for 2015: 38

2014

52: Crystal structure of Bombyx mori lipoprotein 6: comparative structural analysis of the 30-kDa lipoprotein family
Pietrzyk AJ, Bujacz A, Lochynska M, Jaskolski M, Bujacz G
PLoS One. 2014 Nov 7;9(11):e108761
DOI: 10.1371/JOURNAL.PONE.0108761 | PUBMED: 25379889 | IF(2018) = 2.8
PDB [P14]: 4PC4

51: Discovery and characterization of novel selective inhibitors of carbonicanhydrase IX.
Dudutiene V, Matuliene J, Smirnov A, Timm DD, Zubriene A, Baranauskiene L, Morkunaite V, Smirnoviene J, Michailoviene V, Juozapaitiene V, Mickeviciute A, Kazokaite J, Baksyte S, Kasiliauskaite A, Jachno J, Revuckiene J, Kisonaite M, Pilipuityte V, Ivanauskaite E, Milinaviciute G, Smirnovas V, Petrikaite V, Kairys V, Petrauskas V, Norvaisas P, Linge D, Gibieza P, Capkauskaite E, Zaksauskas A, Kazlauskas E, Manakova E, Grazulis S, Ladbury JE, Matulis D
J Med Chem. 2014 Nov 26;57(22):9435-46.
DOI: 10.1021/JM501003K | PUBMED: 25358084 | IF(2014) = 5.4
PDB [P13]: 4Q07 4PZH 4Q06 4Q09 4Q08

50: Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Tamulaitiene G, Silanskas A, Grazulis S, Zaremba M, Siksnys V.
Nucleic Acids Res. 2014 Dec 16;42(22):14022-30.
DOI: 10.1093/NAR/GKU1237 | PUBMED: 25429979 | IF(2018) = 11.1
PDB [P13]: 4RD5

49: Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin.
Grudnik P, Debowski D, Legowska A, Malicki S, Golik P, Karna N, Rolka K, Dubin G.
Proteins. 2014 Dec 24.
DOI: 10.1002/PROT.24750 | PUBMED: 25546528 | IF(2014) = 2.9
PDB [P13]: 4U2W

48: 4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.
Rutkauskas K, Zubriene A, Tumosiene I, Kantminiene K, Kazemekaite M, Smirnov A, Kazokaite J, Morkunaite V, Capkauskaite E, Manakova E, Grazulis S, Beresnevicius ZJ, Matulis D
Molecules (2014) 19: 17356-17380
DOI: 10.3390/MOLECULES191117356 | PUBMED: 25353386 | IF(2020) = 3.3
PDB [P13]: 4Q6E 4Q6D

47: Schulz EC, Barabas O
Structure of an Escherichia coli Hfq:RNA complex at 0.97 A resolution.
Acta Crystallogr Sect F. (2014) 70: 1492-1497
DOI: 10.1107/S2053230X14020044 | PUBMED: 25372815 | IF(2019) = 0.97
PDB [P13]: 4PNO

46: Das, U., Pogenberg, V., Tiruttani Subhramanyam, U.K., Wilmanns, M., Gourinath, S., Srinivasan, A.
Crystal Structure of the Vapbc-15 Complex from Mycobacterium Tuberculosis Reveals a Two-Metal Ion Dependent Pin-Domain Ribonuclease And a Variable Mode of Toxin-Antitoxin Assembly
J Struct Biol. (2014) 188:249-258
DOI: 10.1016/J.JSB.2014.10.002 | PUBMED: 25450593 | IF(2014) = 3.4
PDB [P13]: 4CHG

45: Crystal structure of the rigor-like human non-muscle myosin-2 motor domain.
Munnich S,Pathan-Chhatbar S,Manstein DJ
FEBS Lett. 2014 Dec 20;588(24):4754-60.
DOI: 10.1016/j.febslet.2014.11.007 | PUBMED: 25451231 | IF(2018) = 2.7
PDB [P14]: 4PD3

44: Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress.
Chaves-Sanjuan A, Sanchez-Barrena MJ, Gonzalez-Rubio JM, Moreno M, Ragel P, Jimenez M, Pardo JM, Martinez-Ripoll M, Quintero FJ, Albert A.
Proc Natl Acad Sci U S A. (2014) Oct 6.
DOI: 10.1073/PNAS.1407610111 | PUBMED: 25288725 | IF(2014) = 9.6
PDB [P13]: 4D28

43: Sainz-Polo MA, Valenzuela SV, Gonzále B, Pastor F2, Sanz-Aparicio J.
Structural analysis of glucuronoxylan specific Xyn30D and its attached CBM35 domain give insights into the role of modularity in specificity
J Biol Chem. 2014 Sep 8.
DOI: 10.1074/JBC.M114.597732 | PUBMED: 25202007 | IF(2018) = 4.1
PDB [P13]: 4QB2

42: Kuhle B, Ficner R.
A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
EMBO J. 2014 Sep 15.
DOI: 10.15252/EMBJ.201488517 | PUBMED: 25225612 | IF(2013) = 10.7
PDB [P13]: 4TMV

41: Liu Y, Neumann P, Kuhle B, Monecke T, Schell S, Chari A, Ficner R.
Translation initiation factor eIF3b contains a nine-bladed β-propeller and interacts with the 40S ribosomal subunit.
Structure. 2014 Jun 10;22(6):923-30
DOI: 10.1016/J.STR.2014.03.010 | PUBMED: 24768115 | IF(2013) = 5.3
PDB [P13]: 4NOX

40: Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HD, Svergun DI, Zhang Y, Wang JH, Meijers R.
The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue.
Neuron. 2014 Aug 20;83(4):839-49
DOI: 10.1016/J.NEURON.2014.07.010 | PUBMED: 25123307 | IF(2013) = 16.5
PDB [P14]: 4URT

39: Benini S, Cianci M, Mazzei L, Ciurli S.
Fluoride inhibition of Sporosarcina pasteurii urease: structure and thermodynamics.
J Biol Inorg Chem. 2014 epub
DOI: 10.1007/S00775-014-1182-X | PUBMED: 25113581 | IF(2018) = 3.6
PDB [P13]: 4CEU 4CEX

38: Salamun J, Kallio JP, Daher W, Soldati-Favre D, Kursula I.
Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress.
FASEB J. 2014 Aug 11.
DOI: 10.1096/fj.14-252569 | PUBMED: 25114175
PDB [P14]: 4OZU

37: Prokofev, I.I., Lashkov, A.A., Gabdoulkhakov, A.G., Dontsova, M.V., Seregina, T.A., Mironov, A.S., Betzel, C., Mikhailov, A.M.
Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil
Acta Crystallogr Sect F. 70: 60-63 (2014)
DOI: 10.1107/S2053230X13031877 | PUBMED: 24419619 | IF(2019) = 0.97
PDB [P13]: 4K6O

36: Dunne M, Mertens HD, Garefalaki V, Jeffries CM, Thompson A, Lemke EA, Svergun DI, Mayer MJ, Narbad A, Meijers R.
The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor.
PLoS Pathog. 2014 Jul 24;10(7):e1004228.
DOI: 10.1371/journal.ppat.1004228 | PUBMED: 25058163 | IF(2013) = 8.7
PDB [P14]: 4CU2

35: Sauter, A., Oelker, M., Zocher, G., Zhang, F., Stehle, T., Schreiber, F.
Non-Classical Pathways of Protein Crystallization in the Presence of Multivalent Metal Ions
Cryst Growth Des. 2014, 14, 12, 6357-6366
DOI: 10.1021/cg501099d | PUBMED:
PDB [P13]: 4LZV

34: Wen Y, Behiels E, Felix J, Elegheert J, Vergauwen B, Devreese B, Savvides SN.
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res. 2014 Nov 1;42(15):10134-47
DOI: 10.1093/nar/gku665 | PUBMED: 25056321 | IF(2018) = 11.1
PDB [P13]: 4PU4 4PU5 4PU7 4PU8

33: Specific binding of gibberellic acid by Cytokinin-Specific Binding Proteins: a new aspect of plant hormone-binding proteins with the PR-10 fold.
Ruszkowski M, Sliwiak J, Ciesielska A, Barciszewski J, Sikorski M, Jaskolski M.
Acta Crystallogr Sect D. 70: 2032-2041 (2014)
DOI: 10.1107/S1399004714010578 | PUBMED: 25004979 | IF(2018) = 3.2
PDB [P14]: 4PSB

32: Chasing Protons: How Isothermal Titration Calorimetry, Mutagenesis, and pKa Calculations Trace the Locus of Charge in Ligand Binding to a tRNA-Binding Enzyme.
Neeb M1, Czodrowski P, Heine A, Barandun LJ, Hohn C, Diederich F, Klebe G.
J Med Chem. 2014 Jul 10;57(13):5554-65.
DOI: 10.1021/jm500401x | PUBMED: 24955548 | IF(2018) = 6.1
PDB [P14]: 4PUN 4PUM 4PUL

31: Kuhle, B., Ficner, R.
eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
EMBO J. 33:1177-91 (2014).
DOI: 10.1002/embj.201387344 | PUBMED: 24686316 | IF(2018) = 11.2
PDB [P13]: 4N3N 4N3G 4NCL 4N3S 4NCF

30: Bjerregaard-Andersen, K., Sommer, T., Jensen, J.K., Jochimsen, B., Etzerodt, M., Morth, J.P.
A proton wire and water channel revealed in the crystal structure of isatin hydrolase
J Biol Chem. 2014 Jun 10.
DOI: 10.1074/jbc.M114.568824 | PUBMED: 24917679 | IF(2018) = 4.1
PDB [P13]: 4M8D

29: Janke, R., Goerner, C., Hirte, M., Brueck, T., Loll, B
The first structure of a bacterial diterpene cyclase: CotB2
Acta Crystallogr Sect D. D70 (2014)
DOI: 10.1107/S1399004714005513 | PUBMED: 24914964 | IF(2018) = 3.2
PDB [P14]: 4OMH 4OMG

28: Mierzejewska, K., Siwek, W., Czapinska, H., Skowronek, K., Bujnicki, J.M., Bochtler, M.
Structural basis of the methylation specificity of R.DpnI.
Nucleic Acids Res. 42: 8745-8754 (2014)
DOI: 10.1093/nar/gku546 | PUBMED: 24966351 | IF(2018) = 11.1
PDB [P14]: 4KYW

27: Espina, G., Eley, K., Pompidor, G., Schneider, T.R., Crennell, S.J., Danson, M.J.
A novel β-xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds.
Acta Crystallogr Sect D. 70: 1366 (2014)
DOI: 10.1107/S1399004714002788 | PUBMED: 24816105 | IF(2018) = 3.2
PDB [P13]: 4C1O

26: Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping.
Han H, Kursula P.
J Biol Chem (2014 May)289:14121-14131
DOI: 10.1074/jbc.M114.554816 | PUBMED: 24675079
PDB [P13]: 4CMZ 4CN0

25: Kazrani, A.A., Kowalska, M., Czapinska, H., Bochtler, M.
Crystal structure of the 5hmC specific endonuclease PvuRts1I
Nucleic Acids Res. 2014 Mar 25. [Epub ahead of print]
DOI: 10.1093/nar/gku186 | PUBMED: 24634440 | IF(2018) = 11.1
PDB [P13]: 4OQ2

24: Structural basis of the proinflammatory signaling complex mediated by TSLP
Verstraete, K, van Schie, L, Vyncke, L, Bloch, Y, Tavernier, J, Pauwels, E, Peelman, F, Savvides, SN
Nat Struct Mol Biol. 2014 Apr;21(4):375-82.
DOI: 10.1038/nsmb.2794 | PUBMED: 24632570 | IF(2013) = 11.6
PDB [P13]: 4NN5 4NN6 4NN7

23: Crystal structures of two tetrameric β-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora.
Lehneck R, Neumann P, Vullo D, Elleuche S, Supuran CT, Ficner R, Pöggeler S.
FEBS J. 2014 Apr;281(7):1759-72.
DOI: 10.1111/febs.12738 | PUBMED: 24506675 | IF(2018) = 4.7
PDB [P13]: 4O1K

22: Role of kappa -> lambda light-chain constant-domain switch in the structure and functionality of A17 reactibody
N. Ponomarenko, S. D. Chatziefthimiou, I. Kurkova, Yu. Mokrushina, Y. Mokrushina, A. Stepanova, I. Smirnov, M. Avakyan, T. Bobik, A. Mamedov, V. Mitkevich, A. Belogurov Jr, O. S. Fedorova, M. Dubina, A. Golovin, V. Lamzin, A. Friboulet, A. A. Makarov, M. Wilmanns and A. Gabibov
Acta Crystallogr D Biol Crystallogr. (2014) D70:708-719
DOI: 10.1107/S1399004713032446 | PUBMED: 24598740 | IF(2018) = 3.2
PDB [P14]: 3ZL4

21: Structural Basis for Binding of Fluorinated Glucose and Galactose to Trametes multicolor Pyranose 2-Oxidase Variants with Improved Galactose Conversion
Tan TC, Spadiut O, Gandini R, Haltrich D, Divne C.
PLoS One. 2014; 9(1): e86736
DOI: 10.1371/journal.pone.0086736 | PUBMED: 24466218 | IF(2018) = 2.8
PDB [P13]: 4MOG 4MOI 4MOR

20: Serial crystallography on in vivo-grown microcrystals using synchrotron radiation
Gati, C., Bourenkov, G., Klinge, M., Rehders, D., Stellato, F., Oberthuer, D., Yefanov, O., Sommer, B.P., Mogk, S., Duszenko, M. et al. (2014).
IUCrJ. (2014) 1 87-94
DOI: 10.1107/S2052252513033939 | PUBMED: 25075324 | IF(2020) = 4
PDB [P14]: 4N4Z

19: Resolving the activation site of positive regulators in plant phosphoenolpyruvate carboxylase.
Schlieper D, Förster, K, Paulus JK, Groth G
Mol Plant. 7:437-40 (2014)
DOI: 10.1093/mp/sst130 | PUBMED: 24043710 | IF(2019) = 10.8
PDB [P14]: 4BXC

Number of publications for 2014: 34

2013

18: CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis.
Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T.
Cell. 155:647 (2013).
DOI: 10.1016/j.cell.2013.09.050 | PUBMED: 24243021 | IF(2018) = 36.2
PDB [P14]: 4C2G

17: Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII
Capkauskaite E, Zubriene A, Smirnov A, Torresan J, Kišonaie M, Kazokaite J, Gylyte J, Michailoviene V, Jogaite V, Manakova E, Gražulis S, Tumkevcius S, Matulis D.
Bioorg Med Chem. 21:6937-6947 (2013)
DOI: 10.1016/j.bmc.2013.09.029 | PUBMED: 24103428 | IF(2018) = 2.5
PDB [P14]: 4KNN 4KP5

16: The landscape of cytokinin binding by a plant nodulin.
Ruszkowski M, Szpotkowski K, Sikorski M, Jaskolski M.
Acta Crystallogr D Biol Crystallogr. (2013) 69:2365-80
DOI: 10.1107/S0907444913021975 | PUBMED: 24311578 | IF(2018) = 3.2
PDB [P14]: 4GY9

15: Crystal structure of the 14-subunit RNA polymerase I
Fernandez-Tornero C, Moreno-Morcillo M, Rashid UJ, Taylor NM, Ruiz FM, Gruene T, Legrand P, Steuerwald U, Mueller CW.
Nature. 502:644 (2013)
DOI: 10.1038/nature12636 | PUBMED: 24153184 | IF(2018) = 43.1
PDB [P14]: 4C3I

14: Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency
Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE.
PLoS Pathog. 9(10):e1003673 (2013)
DOI: 10.1371/journal.ppat.1003673 | PUBMED: 24146618 | IF(2018) = 6.1
PDB [P14]: 4BLG

13: Iron Binding at Specific Sites within the Octameric HbpS Protects Streptomycetes from Iron-Mediated Oxidative Stress.
Wedderhoff I, Kursula I, Groves MR, Ortiz de Orué Lucana .
PLoS One. 2013 Aug 27;8(8):e71579.
DOI: 10.1371/journal.pone.0071579 | PUBMED: 24013686 | IF(2018) = 2.8
PDB [P13]: 4BMW

12: Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus.
Coronado MA, Gabdulkhakov A, Georgieva D, Sankaran B, Murakami MT, Arni RK, Betzel C.
Acta Crystallogr D Biol Crystallogr. D69:1958-64 (2013)
DOI: 10.1107/S0907444913018003 | PUBMED: 24100315 | IF(2018) = 3.2
PDB [P14]: 4GV5

11: Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
Punekar AS, Liljeruhm J, Shepherd TR, Forster AC, Selmer M.
Nucleic Acids Res. 41(20):9537-48 (2013)
DOI: 10.1093/nar/gkt719 | PUBMED: 23945937 | IF(2018) = 11.1
PDB [P13]: 4BLW

10: Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.
Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA.
Nucleic Acids Res. 2013 41(11):5912
DOI: 10.1093/nar/gkt268 | PUBMED: 23595147 | IF(2018) = 11.1
PDB [P14]: 3ZLA

9: The hepatitis B virus preS1 domain hijacks host trafficking proteins by motif mimicry.
Jürgens MC, Vürüs J, Rautureau GJ, Shepherd DA, Pye VE, Muldoon J, Johnson CM, Ashcroft AE, Freund SM, Ferguson N.
Nat Chem Biol. 2013 Sep;9(9):540-7.
DOI: 10.1038/nchembio.1294. | PUBMED: 23851574 | IF(2013) = 13.2
PDB [P14]: 3ZHF

8: Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family
Myllykoski M, Raasakka A, Lehtimäki M, Han H, Kursula I, Kursula P.
J Mol Biol. 425:4307-22 (2013)
DOI: 10.1016/j.jmb.2013.06.012 | PUBMED: 23831225 | IF(2018) = 5.1
PDB [P14]: 2YPC

7: Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann C C, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner K P
Nature. 2013 498:332-337
DOI: 10.1038/nature12305 | PUBMED: 23722159 | IF(2014) = 41.4
PDB [P14]: 4KB6

6: Cloning, expression, purification, crystallization and preliminary X-ray analysis of EaLsc, a levansucrase from Erwinia amylovora
Caputi L, Cianci M, Benini S
Acta Crystallogr F Struct Biol Commun. F69:570-573 (2013)
DOI: 10.1107/S1744309113010750 | PUBMED: 23695580 | IF(2019) = 0.97
PDB [P13]:

5: Greater efficiency of photosynthetic carbon fixation due to single amino-acid substitution.
Paulus JK, Schlieper D, Groth G.
Nat Commun. 4:1518 (2013)
DOI: 10.1038/ncomms2504 | PUBMED: 23443546 | IF(2013) = 10.2
PDB [P14]: 3ZGB

4: The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design
Benini S, Kosikowska P, Cianci M, Mazzei L, Vara AG, Berlicki , Ciurli S
J Biol Inorg Chem. 2013 Mar;18(3):391-9.
DOI: 10.1007/s00775-013-0983-7 | PUBMED: 23412551 | IF(2018) = 3.6
PDB [P14]: 4AC7

3: A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.
Malvezzi F, Litos G, Schleiffer A, Heuck A, Mechtler K, Clausen T, Westermann S.
EMBO J. 2013 Feb 6;32(3):409-23.
DOI: 10.1038/emboj.2012.356 | PUBMED: 23334295 | IF(2018) = 11.2
PDB [P14]: 4GEQ

Number of publications for 2013: 16

2012

2: Structural basis for cooperativity of CRM1 export complex formation.
Monecke T, Haselbach D, VoßB, Russek A, Neumann P, Thomson E, Hurt E, Zachariae U, Stark H, Grubmüller H, Dickmanns A, Ficner R.
Proc Natl Acad Sci U S A. 2012 Dec 31. [Epub ahead of print]
DOI: 10.1073/pnas.1215214110 | PUBMED: 23277578 | IF(2019) = 9.4
PDB [P14]: 4HZK

1: Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Santos KF, Jovin SM, Weber G, Pena V, Lührmann R, Wahl MC
Proc Natl Acad Sci U S A. (2012) Oct 23;109(43):17418-23. Epub 2012 Oct 8.
DOI: 10.1073/nas.1208098109 | PUBMED: 23045696 | IF(2019) = 9.4
PDB [P14]: 4F91