Total number of publications referencing P13 (360) and/or P14 (225): 585 [ as of 10/05/2023 ]

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2023

585: The effects of nature-inspired amino acid substitutions on structural and biochemical properties of the E. coli L-asparaginase EcAIII.
Janicki M, Ściuk A, Zielezinski A, Ruszkowski M, Ludwików A, Karlowski WM, Jaskolski M, Loch JI.
Protein Sci (2023 Apr)UNK:e4647
DOI: 10.1002/pro.4647  |   PUBMED: 37095066  |   IF(2018) = 2.4
PDB [P13]:  8BKF  8C23  8BI3   

584: Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
Kaspers MS, Pogenberg V, Pett C, Ernst S, Ecker F, Ochtrop P, Groll M, Hedberg C, Itzen A.
Nat Commun (2023 Apr)14:2245
DOI: 10.1038/s41467-023-37621-7  |   PUBMED: 37076474  |   IF(2022) = 14.9
PDB [P13]:  8AGG  8ALK   

583: Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability.
Sutinen A, Paffenholz D, Nguyen GTT, Ruskamo S, Torda AE, Kursula P.
PLoS One (2023 )18:e0284532
DOI: 10.1371/journal.pone.0284532  |   PUBMED: 37058526  |   IF(2018) = 2.8
PDB [P13]:  8A4J   

582: Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction.
Chan DCK, Josts I, Koteva K, Wright GD, Tidow H, Burrows LL.
Proc Natl Acad Sci U S A (2023 Apr)120:e2221253120
DOI: 10.1073/pnas.2221253120  |   PUBMED: 37043535  |   IF(2019) = 9.4
PDB [P13]:  8B43   

581: Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Tsirigotaki A, Dansercoer A, Verschueren KHG, Marković I, Pollmann C, Hafer M, Felix J, Birck C, Van Putte W, Catteeuw D, Tavernier J, Fernando Bazan J, Piehler J, Savvides SN, Verstraete K.
Nat Struct Mol Biol. (2023 Mar)UNK:pp. UNK
DOI: 10.1038/s41594-023-00941-9  |   PUBMED: 36959263  |   IF(2019) = 11.7
PDB [P13]:  8AV2  7Z3Q  7Z3R   

580: Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and Sulfoxidations.
Kratky J, Eggerichs D, Heine T, Hofmann S, Sowa P, Weiße RH, Tischler D, Sträter N.
Angew Chem Int Ed Engl (2023 Apr)62:e202300657
DOI: 10.1002/anie.202300657  |   PUBMED: 36762980  |   IF(2019) = 13.0
PDB [P14]:  7Z97   

579: Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6).
Rutkiewicz M, Nogues I, Witek W, Angelaccio S, Contestabile R, Ruszkowski M.
Plant Physiol Biochem (2023 Mar)196:759-773
DOI: 10.1016/j.plaphy.2023.02.017  |   PUBMED: 36842242  |   IF(2019) = 3.72
PDB [P13]:  8BJ4   

578: Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.
Soni K, Sivadas A, Horvath A, Dobrev N, Hayashi R, Kiss L, Simon B, Wild K, Sinning I, Fischer T.
Nat Commun. (2023 Feb)14:772
DOI: 10.1038/s41467-023-36402-6  |   PUBMED: 36774373  |   IF(2022) = 14.9
PDB [P13P14]:  7Q74  7Q72  7Q73   

577: Cytidine deaminases catalyze the conversion of N(S,O)⁴-substituted pyrimidine nucleosides.
Urbelienė N, Tiškus M, Tamulaitienė G, Gasparavičiūtė R, Lapinskaitė R, Jauniškis V, Sūdžius J, Meškienė R, Tauraitė D, Skrodenytė E, Urbelis G, Vaitekūnas J, Meškys R.
Sci Adv (2023 Feb)9:eade4361
DOI: 10.1126/sciadv.ade4361  |   PUBMED: 36735785  |   IF(2018) = 12.5
PDB [P13]:  7ZOB   

576: Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria.
Shuoker B, Pichler MJ, Jin C, Sakanaka H, Wu H, Gascueña AM, Liu J, Nielsen TS, Holgersson J, Nordberg Karlsson E, Juge N, Meier S, Morth JP, Karlsson NG, Abou Hachem M.
Nat Commun (2023 Apr)14:1833
DOI: 10.1038/s41467-023-37533-6  |   PUBMED: 37005422  |   IF(2022) = 14.9
PDB [P14]:  8AXT  8AYR   

575: Does the presence of ground state complex between a PR-10 protein and a sensitizer affect the mechanism of sensitized photo-oxidation?
Ignasiak-Kciuk M, Nowicka-Bauer K, Grzechowiak M, Ravnsborg T, Frąckowiak K, Jensen ON, Jaskólski M, Marciniak B.
Free Radic Biol Med (2023 Mar)198:27-43
DOI: 10.1016/j.freeradbiomed.2023.01.022  |   PUBMED: 36738800
PDB [P14]:  7QB6   

574: Structural basis of the activation of PPARγ by the plasticizer metabolites MEHP and MINCH.
Useini A, Engelberger F, Künze G, Sträter N.
Environ Int (2023 Mar)173:107822
DOI: 10.1016/j.envint.2023.107822  |   PUBMED: 36841188
PDB [P13]:  8BF1   

573: X-ray structure and function of fibronectin domains two and three of the neural cell adhesion molecule L1.
Guédez G, Loers G, Jeffries CM, Kozak S, Meijers R, Svergun DI, Schachner M, Löw C.
FASEB J (2023 Mar)37:e22823
DOI: 10.1096/fj.202201511r  |   PUBMED: 36809668
PDB [P13]:  8AFP  8AFO   

572: Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.
Talaj JA, Zielinski K, Bujacz A.
Int J Mol Sci (2023 Jan)24:1534
DOI: 10.3390/ijms24021534  |   PUBMED: 36675044  |   IF(2018) = 4.2
PDB [P14]:  6HN0   

571: MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus.
Shearer HL, Loi VV, Weiland P, Bange G, Altegoer F, Hampton MB, Antelmann H, Dickerhof N.
Mol Microbiol (2023 Apr)119:456-470
DOI: 10.1111/mmi.15035  |   PUBMED: 36779383  |   IF(2018) = 3.6
PDB [P13]:  8AJK  8AJJ   

570: Parameterization of a single H-bond in Orange Carotenoid Protein by atomic mutation reveals principles of evolutionary design of complex chemical photosystems.
Moldenhauer M, Tseng HW, Kraskov A, Tavraz NN, Yaroshevich IA, Hildebrandt P, Sluchanko NN, Hochberg GA, Essen LO, Budisa N, Korf L, Maksimov EG, Friedrich T.
Front Mol Biosci (2023 )10:1072606
DOI: 10.3389/fmolb.2023.1072606  |   PUBMED: 36776742  |   IF(2022) = 4.6
PDB [P14]:  7ZXV   

569: Fortuitously compatible protein surfaces primed allosteric control in cyanobacterial photoprotection.
Steube N, Moldenhauer M, Weiland P, Saman D, Kilb A, Ramírez Rojas AA, Garg SG, Schindler D, Graumann PL, Benesch JLP, Bange G, Friedrich T, Hochberg GKA.
Nat Ecol Evol (2023 Apr)UNK:pp. UNK
DOI: 10.1038/s41559-023-02018-8  |   PUBMED: 37012377
PDB [P13]:  8AG8   

568: Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein.
Hollmann NM, Jagtap PKA, Linse JB, Ullmann P, Payr M, Murciano B, Simon B, Hub JS, Hennig J.
Nucleic Acids Res (2023 Feb)51:1895-1913
DOI: 10.1093/nar/gkac1277  |   PUBMED: 36688322  |   IF(2018) = 11.1
PDB [P13]:  7ZHH   

567: Improved cytosine base editors generated from TadA variants.
Lam DK, Feliciano PR, Arif A, Bohnuud T, Fernandez TP, Gehrke JM, Grayson P, Lee KD, Ortega MA, Sawyer C, Schwaegerle ND, Peraro L, Young L, Lee SJ, Ciaramella G, Gaudelli NM.
Nat Biotechnol. (2023 Jan)UNK:pp. UNK
DOI: 10.1038/s41587-022-01611-9  |   PUBMED: 36624149
PDB [P13]:  8E2S   

566: Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Rotheneder M, Stakyte K, van de Logt E, Bartho JD, Lammens K, Fan Y, Alt A, Kessler B, Jung C, Roos WP, Steigenberger B, Hopfner KP.
Mol Cell. (2023 Jan)83:167-185.e9
DOI: 10.1016/j.molcel.2022.12.003  |   PUBMED: 36577401  |   IF(2018) = 14.5
PDB [P14]:  7ZQY   

565: Linking medicinal cannabis to autotaxin-lysophosphatidic acid signaling.
Eymery MC, McCarthy AA, Hausmann J.
Life Sci Alliance (2023 Feb)6:e202201595
DOI: 10.26508/lsa.202201595  |   PUBMED: 36623871
PDB [P13P14]:  7P4O  7P4J   

564: Right-handed Z-DNA at ultrahigh resolution: a tale of two hands and the power of the crystallographic method.
Drozdzal P, Manszewski T, Gilski M, Brzezinski K, Jaskolski M.
Acta Crystallogr D Struct Biol (2023 Feb)79:133-139
DOI: 10.1107/s2059798322011937  |   PUBMED: 36762859  |   IF(2018) = 3.2
PDB [P13]:  8A71   

563: Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase.
Bürgi J, Lill P, Giannopoulou EA, Jeffries CM, Chojnowski G, Raunser S, Gatsogiannis C, Wilmanns M.
Biol Chem. (2023 Feb)404:195-207
DOI: 10.1515/hsz-2022-0273  |   PUBMED: 36694962
PDB [P13]:  8AFG   

562: Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors.
Krammer EM, Bridot C, Serna S, Echeverria B, Semwal S, Roubinet B, van Noort K, Wilbers RP, Bourenkov G, de Ruyck J, Landemarre L, Reichardt N, Bouckaert J.
J Biol Chem (2023 Mar)UNK:104627
DOI: 10.1016/j.jbc.2023.104627  |   PUBMED: 36944399  |   IF(2018) = 4.1
PDB [P14]:  8BY3   

561: A Key Role in Catalysis and Enzyme Thermostability of a Conserved Helix H5 Motif of Human Glutathione Transferase A1-1.
Chronopoulou EG, Mutabdzija L, Poudel N, Papageorgiou AC, Labrou NE.
Int J Mol Sci (2023 Feb)24:3700
DOI: 10.3390/ijms24043700  |   PUBMED: 36835112  |   IF(2018) = 4.2
PDB [P13]:  8BHE  8BHC   

560: Structural Basis for a Cork-Up Mechanism of the Intra-Molecular Mesaconyl-CoA Transferase.
Pfister P, Zarzycki J, Erb TJ.
Biochemistry. (2023 Jan)62:75-84
DOI: 10.1021/acs.biochem.2c00532  |   PUBMED: 36535006  |   IF(2018) = 3.0
PDB [P14]:  8APQ   

Number of publications for 2023: 26

2022

559: Structural insights into the function-modulating effects of nanobody binding to the integrin receptor α_Mβ₂.
Jensen RK, Pedersen H, Lorentzen J, Laursen NS, Vorup-Jensen T, Andersen GR.
J Biol Chem (2022 Aug)298:102168
DOI: 10.1016/j.jbc.2022.102168  |   PUBMED: 35738398  |   IF(2018) = 4.1
PDB [P14]:  7NP9   

558: The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Brinkhaus M, Pannecoucke E, van der Kooi EJ, Bentlage AEH, Derksen NIL, Andries J, Balbino B, Sips M, Ulrichts P, Verheesen P, de Haard H, Rispens T, Savvides SN, Vidarsson G.
Nat Commun (2022 Oct)13:6073
DOI: 10.1038/s41467-022-33764-1  |   PUBMED: 36241613  |   IF(2022) = 14.9
PDB [P14]:  7Q3P   

557: A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.
Erven I, Abraham E, Hermanns T, Baumann U, Hofmann K.
Nat Commun (2022 Dec)13:7643
DOI: 10.1038/s41467-022-35244-y  |   PUBMED: 36496440  |   IF(2022) = 14.9
PDB [P13]:  8ADD  8ADB  8ADC   

556: Antiviral signaling by a cyclic nucleotide activated CRISPR protease.
Rouillon C, Schneberger N, Chi H, Blumenstock K, Da Vela S, Ackermann K, Moecking J, Peter MF, Boenigk W, Seifert R, Bode BE, Schmid-Burgk JL, Svergun D, Geyer M, White MF, Hagelueken G.
Nature (2022 Nov)UNK:pp. UNK
DOI: 10.1038/s41586-022-05571-7  |   PUBMED: 36423657
PDB [P13]:  8B0U  8B0R  7QDA   

555: Structural, Thermodynamic and Enzymatic Characterization of N,N-Diacetylchitobiose Deacetylase from Pyrococcus chitonophagus.
Biniek-Antosiak K, Bejger M, Śliwiak J, Baranowski D, Mohammed ASA, Svergun DI, Rypniewski W.
Int J Mol Sci (2022 Dec)23:15736
DOI: 10.3390/ijms232415736  |   PUBMED: 36555375  |   IF(2018) = 4.2
PDB [P13]:  8BGO  8BGP  8BGN   

554: Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Orsi DL, Ferrara SJ, Siegel S, Friberg A, Bouché L, Pook E, Lienau P, Bluck JP, Lemke CT, Akcay G, Stellfeld T, Meyer H, Pütter V, Holton SJ, Korr D, Jerchel-Furau I, Pantelidou C, Strathdee CA, Meyerson M, Eis K, Goldstein JT.
Bioorg Med Chem (2022 Dec)78:117130
DOI: 10.1016/j.bmc.2022.117130  |   PUBMED: 36542958  |   IF(2018) = 2.5
PDB [P14]:  8B94  8B95  8B8Y   

553: Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis.
Minazzato G, Gasparrini M, Heroux A, Sernova NV, Rodionov DA, Cianci M, Sorci L, Raffaelli N.
J Struct Biol (2022 Dec)214:107917
DOI: 10.1016/j.jsb.2022.107917  |   PUBMED: 36332744  |   IF(2018) = 3.8
PDB [P13]:  7Q93  7Q94   

552: A MademoiseLLE domain binding platform links the key RNA transporter to endosomes.
Devan SK, Schott-Verdugo S, Müntjes K, Bismar L, Reiners J, Hachani E, Schmitt L, Höppner A, Smits SH, Gohlke H, Feldbrügge M.
PLoS Genet (2022 Jun)18:e1010269
DOI: 10.1371/journal.pgen.1010269  |   PUBMED: 35727840
PDB [P14]:  7PZE   

551: Cyanide Binding to [FeFe]-Hydrogenase Stabilizes the Alternative Configuration of the Proton Transfer Pathway.
Duan J, Hemschemeier A, Burr DJ, Stripp ST, Hofmann E, Happe T.
Angew Chem Int Ed Engl. (2022 Dec)UNK:pp. UNK
DOI: 10.1002/anie.202216903  |   PUBMED: 36464641  |   IF(2019) = 13.0
PDB [P13P14]:  8ALN  8AP2   

550: Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans
Hassani Nia F, Woike D, Bento I, Niebling S, Tibbe D, Schulz K, Hirnet D, Skiba M, Hönck HH, Veith K, Günther C, Scholz T, Bierhals T, Driemeyer J, Bend R, Failla AV, Lohr C, Alai MG, Kreienkamp HJ.
Mol Psychiatry. (2022 Nov)UNK:pp. UNK
DOI: 10.1038/s41380-022-01882-3  |   PUBMED: 36450866  |   IF(2022) = 16.0
PDB [P14]:  8ATJ  8B10   

549: Characterization of a glycoside hydrolase endolysin from Acinetobacter baumannii phage AbTZA1 with high antibacterial potency and novel structural features.
Premetis GE, Stathi A, Papageorgiou AC, Labrou NE.
FEBS J. (2022 Nov)UNK:pp. UNK
DOI: 10.1111/febs.16686  |   PUBMED: 36413083  |   IF(2018) = 4.7
PDB [P13]:  8APP   

548: Disarming of type I-F CRISPR-Cas surveillance complex by anti-CRISPR proteins AcrIF6 and AcrIF9.
Kupcinskaite E, Tutkus M, Kopūstas A, Ašmontas S, Jankunec M, Zaremba M, Tamulaitiene G, Sinkunas T.
Sci Rep. (2022 Sep)12:15548
DOI: 10.1038/s41598-022-19797-y  |   PUBMED: 36109551  |   IF(2022) = 5.0
PDB [P13]:  7BB5   

547: The Na⁺,K⁺-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state.
Fruergaard MU, Dach I, Andersen JL, Ozol M, Shahsavar A, Quistgaard EM, Poulsen H, Fedosova NU, Nissen P.
J Biol Chem (2022 Sep)298:102317
DOI: 10.1016/j.jbc.2022.102317  |   PUBMED: 35926706  |   IF(2018) = 4.1
PDB [P13P14]:  7QTV   

546: The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach.
Shao J, Kuiper BP, Thunnissen AWH, Cool RH, Zhou L, Huang C, Dijkstra BW, Broos J.
J Am Chem Soc (2022 Aug)144:13815-13822
DOI: 10.1021/jacs.2c04986  |   PUBMED: 35868012  |   IF(2018) = 14.7
PDB [P13]:  7QZ8   

545: Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8.
Preussner M, Santos KF, Alles J, Heroven C, Heyd F, Wahl MC, Weber G.
Acta Crystallogr D Struct Biol (2022 Nov)78:1373-1383
DOI: 10.1107/s2059798322009755  |   PUBMED: 36322420  |   IF(2018) = 3.2
PDB [P14]:  7PJH   

544: Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases.
Verma A, Åberg-Zingmark E, Sparrman T, Mushtaq AU, Rogne P, Grundström C, Berntsson R, Sauer UH, Backman L, Nam K, Sauer-Eriksson E, Wolf-Watz M.
Sci Adv (2022 Nov)8:eabm4089
DOI: 10.1126/sciadv.abm4089  |   PUBMED: 36332013  |   IF(2018) = 12.5
PDB [P13]:  7OWE   

543: Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: towards a model of the C-P4H α₂β₂ tetramer.
Murthy AV, Sulu R, Lebedev A, Salo AM, Korhonen K, Venkatesan R, Tu H, Bergmann U, Jänis J, Laitaoja M, Ruddock L, Myllyharju J, Koski MK, Wierenga RK.
J Biol Chem (2022 Oct)UNK:102614
DOI: 10.1016/j.jbc.2022.102614  |   PUBMED: 36265586  |   IF(2018) = 4.1
PDB [P14]:  7ZSC   

542: Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects.
Adámková K, Koval' T, Østergaard LH, Dušková J, Malý M, Švecová L, Skálová T, Kolenko P, Dohnálek J.
Acta Crystallogr D Struct Biol (2022 Oct)78:1194-1209
DOI: 10.1107/s2059798322008397  |   PUBMED: 36189740  |   IF(2018) = 3.2
PDB [P13]:  7QTB  7QTA   

541: Structural insights into light-driven anion pumping in cyanobacteria.
Astashkin R, Kovalev K, Bukhdruker S, Vaganova S, Kuzmin A, Alekseev A, Balandin T, Zabelskii D, Gushchin I, Royant A, Volkov D, Bourenkov G, Koonin E, Engelhard M, Bamberg E, Gordeliy V.
Nat Commun (2022 Oct)13:6460
DOI: 10.1038/s41467-022-34019-9  |   PUBMED: 36309497  |   IF(2022) = 14.9
PDB [P14]:  7ZOV  7ZOW  7ZOU   

540: Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27.
Składanowska K, Bloch Y, Strand J, White KF, Hua J, Aldridge D, Welin M, Logan DT, Soete A, Merceron R, Murphy C, Provost M, Bazan JF, Hunter CA, Hill JA, Savvides SN.
Cell Rep (2022 Oct)41:111490
DOI: 10.1016/j.celrep.2022.111490  |   PUBMED: 36261006  |   IF(2018) = 8.1
PDB [P14]:  7ZG0   

539: Enzymatic Late-Stage Halogenation of Peptides.
Schnepel C, Moritzer AC, Gäfe S, Montua N, Minges H, Nieß A, Niemann HH, Sewald N.
ChemBioChem. (2022 Oct)UNK:pp. UNK
DOI: 10.1002/cbic.202200569  |   PUBMED: 36259362  |   IF(2018) = 2.6
PDB [P13]:  8AD7   

538: Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Narayanan D, Tran KT, Pallesen JS, Solbak SMØ, Qin Y, Mukminova E, Luchini M, Vasilyeva KO, González Chichón D, Goutsiou G, Poulsen C, Haapanen N, Popowicz GM, Sattler M, Olagnier D, Gajhede M, Bach A.
J Med Chem. (2022 Oct)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.2c00830  |   PUBMED: 36263945  |   IF(2018) = 6.1
PDB [P13P14]:  7OFD  7OFE   

537: Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Markússon S, Hjörleifsson JG, Kursula P, Ásgeirsson B.
Biochemistry (2022 Oct)61:2248-2260
DOI: 10.1021/acs.biochem.2c00438  |   PUBMED: 36194497  |   IF(2018) = 3.0
PDB [P14]:  7QOW  7Z00   

536: High-resolution structure of a fish aquaporin reveals a novel extracellular fold.
Zeng J, Schmitz F, Isaksson S, Glas J, Arbab O, Andersson M, Sundell K, Eriksson LA, Swaminathan K, Törnroth-Horsefield S, Hedfalk K.
Life Sci Alliance (2022 Oct)5:e202201491
DOI: 10.26508/lsa.202201491  |   PUBMED: 36229063
PDB [P13]:  7W7S   

535: Evolution of increased complexity and specificity at the dawn of form I Rubiscos.
Schulz L, Guo Z, Zarzycki J, Steinchen W, Schuller JM, Heimerl T, Prinz S, Mueller-Cajar O, Erb TJ, Hochberg GKA.
Science (2022 Oct)378:155-160
DOI: 10.1126/science.abq1416  |   PUBMED: 36227987  |   IF(2018) = 41.1
PDB [P14]:  7QSV  7QSW   

534: Substrate Induced Movement of the Metal Cofactor between Active and Resting State.
Marsden SR, Wijma HJ, Mohr MKF, Justo I, Hagedoorn PL, Laustsen J, Jeffries CM, Svergun D, Mestrom L, McMillan DGG, Bento I, Hanefeld U.
Angew Chem Int Ed Engl. (2022 Oct)UNK:pp. UNK
DOI: 10.1002/anie.202213338  |   PUBMED: 36214476  |   IF(2019) = 13.0
PDB [P13P14]:  7O9R  7O5W  7OBU  7O87  7NUJ  7NR1  7NNK  8ADQ  7O5I   

533: Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics.
Zavarise A, Sridhar S, Kiema TR, Wierenga RK, Widersten M.
FEBS J. (2022 Aug)UNK:pp. UNK
DOI: 10.1111/febs.16603  |   PUBMED: 36002154  |   IF(2018) = 4.7
PDB [P14]:  7QNI   

532: Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
Weidenhausen J, Kopp J, Ruger-Herreros C, Stein F, Haberkant P, Lapouge K, Sinning I.
Int J Mol Sci (2022 Sep)23:10805
DOI: 10.3390/ijms231810805  |   PUBMED: 36142717  |   IF(2018) = 4.2
PDB [P13]:  7OJU   

531: Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.
Hyjek-Składanowska M, Anderson BA, Mykhaylyk V, Orr C, Wagner A, Poznański JT, Skowronek K, Seth P, Nowotny M.
Nucleic Acids Res. (2022 Sep)UNK:gkac774
DOI: 10.1093/nar/gkac774  |   PUBMED: 36124719  |   IF(2018) = 11.1
PDB [P13]:  7ZVN   

530: Deamidation of the human eye lens protein γS-crystallin accelerates oxidative aging.
Norton-Baker B, Mehrabi P, Kwok AO, Roskamp KW, Rocha MA, Sprague-Piercy MA, von Stetten D, Miller RJD, Martin RW.
Structure. (2022 May)30:763-776.e4
DOI: 10.1016/j.str.2022.03.002  |   PUBMED: 35338852  |   IF(2022) = 5.0
PDB [P13P14]:  7N38  7N39  7N36  7N3A  7N3B  7N37   

529:  Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C.
Killer M, Finocchio G, Mertens HDT, Svergun DI, Pardon E, Steyaert J, Löw C.
Front Mol Biosci. 2022 Jul 11;9:917725.
DOI: 10.3389/fmolb.2022.917725  |   PUBMED: 35898305  |   IF(2022) = 4.6
PDB [P13P14]:   

528: Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.
Müller IK, Winter C, Thomas C, Spaapen RM, Trowitzsch S, Tampé R.
Nat Commun. (2022 Sep)13:5383
DOI: 10.1038/s41467-022-32841-9  |   PUBMED: 36104323  |   IF(2022) = 14.9
PDB [P13]:  7QNG   

527: Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.
Gao S, Sylvester K, Song L, Claff T, Jing L, Woodson M, Weiße RH, Cheng Y, Schäkel L, Petry M, Gütschow M, Schiedel AC, Sträter N, Kang D, Xu S, Toth K, Tavis J, Tollefson AE, Müller CE, Liu X, Zhan P.
J Med Chem. (2022 Sep)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.2c01146  |   PUBMED: 36107752  |   IF(2018) = 6.1
PDB [P13P14]:  8ACD  8ACL   

526: Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Zeke A, Takács T, Sok P, Németh K, Kirsch K, Egri P, Póti ÁL, Bento I, Tusnády GE, Reményi A.
Nat Commun. (2022 Sep)13:5439
DOI: 10.1038/s41467-022-32918-5  |   PUBMED: 36114179  |   IF(2022) = 14.9
PDB [P14]:  7PPL  7PPM  7PPN   

525: Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Figiel M, Gapińska M, Czarnocki-Cieciura M, Zajko W, Sroka M, Skowronek K, Nowotny M.
Nucleic Acids Res. (2022 Sep)50:10026-10040
DOI: 10.1093/nar/gkac772  |   PUBMED: 36107766  |   IF(2018) = 11.1
PDB [P14]:  7R07   

524: Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Shvarev D, Schoppe J, König C, Perz A, Füllbrunn N, Kiontke S, Langemeyer L, Januliene D, Schnelle K, Kümmel D, Fröhlich F, Moeller A, Ungermann C.
Elife. (2022 Sep)11:e80901
DOI: 10.7554/elife.80901  |   PUBMED: 36098503  |   IF(2018) = 7.6
PDB [P13]:  7ZTY   

523: A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
Alexa A, Sok P, Gross F, Albert K, Kobori E, Póti ÁL, Gógl G, Bento I, Kuang E, Taylor SS, Zhu F, Ciliberto A, Reményi A.
Nat Commun. 2022 Jan 25;13(1):472.
DOI: 10.1038/s41467-022-28109-x  |   PUBMED: 35078976  |   IF(2022) = 14.9
PDB [P14]:  7OPO  7OPM   

522: Crystal structures of free and ligand-bound forms of the TetR/AcrR-like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism.
Werten S, Waack P, Palm GJ, Virolle MJ, Hinrichs W.
FEBS J. (2022 Aug)UNK:pp. UNK
DOI: 10.1111/febs.16606  |   PUBMED: 36017630  |   IF(2018) = 4.7
PDB [P13]:  7PT0   

521: Structure of angiogenin dimer bound to double-stranded RNA.
Sievers K, Ficner R.
Acta Crystallogr F Struct Biol Commun (2022 Sep)78:330-337
DOI: 10.1107/s2053230x22008317  |   PUBMED: 36048083  |   IF(2019) = 0.97
PDB [P14]:  8AF0   

520: Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.
Truongvan N, Li S, Misra M, Kuhn M, Schindelin H.
Nat Commun. (2022 Aug)13:4789
DOI: 10.1038/s41467-022-32040-6  |   PUBMED: 35970836  |   IF(2022) = 14.9
PDB [P14]:  7PVN   

519: Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives.
Nogués I, Sekula B, Angelaccio S, Grzechowiak M, Tramonti A, Contestabile R, Ruszkowski M.
Plant Physiol Biochem. (2022 Jul)187:37-49
DOI: 10.1016/j.plaphy.2022.07.025  |   PUBMED: 35947902  |   IF(2019) = 3.72
PDB [P14]:  7QPE   

518: Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Pedersen H, Jensen RK, Hansen AG, Petersen SV, Thiel S, Laursen NS, Andersen GR.
Front Immunol. (2022 )13:872536
DOI: 10.3389/fimmu.2022.872536  |   PUBMED: 35935935  |   IF(2018) = 6.4
PDB [P13]:  7QIV   

517: An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Baker YR, Thorpe C, Chen J, Poller LM, Cox L, Kumar P, Lim WF, Lie L, McClorey G, Epple S, Singleton D, McDonough MA, Hardwick JS, Christensen KE, Wood MJA, Hall JP, El-Sagheer AH, Brown T.
Nat Commun. (2022 Jul)13:4036
DOI: 10.1038/s41467-022-31636-2  |   PUBMED: 35821218  |   IF(2022) = 14.9
PDB [P13]:  7OZZ  7OOS   

516: The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn²⁺ -binding domain essential for structural integrity and channel activity.
Sander S, Pick J, Gattkowski E, Fliegert R, Tidow H.
Protein Sci. (2022 Jun)31:e4320
DOI: 10.1002/pro.4320  |   PUBMED: 35634784  |   IF(2018) = 2.4
PDB [P14]:  7AOV  7RU7   

515: Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin.
Vourloumis D, Mavridis I, Athanasoulis A, Temponeras I, Koumantou D, Giastas P, Mpakali A, Magrioti V, Leib J, van Endert P, Stratikos E, Papakyriakou A.
J Med Chem. (2022 Jul)65:10098-10117
DOI: 10.1021/acs.jmedchem.2c00904  |   PUBMED: 35833347  |   IF(2018) = 6.1
PDB [P13]:  7Z28  7ZYF   

514: Structural Insights into the Role of β3 nAChR Subunit in the Activation of Nicotinic Receptors.
Giastas P, Papakyriakou A, Tsafaras G, Tzartos SJ, Zouridakis M.
Molecules. (2022 Jul)27:4642
DOI: 10.3390/molecules27144642  |   PUBMED: 35889515  |   IF(2020) = 3.3
PDB [P13]:  8A5U   

513: The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity.
Schweininger J, Kriegel M, Häge S, Conrad M, Alkhashrom S, Lösing J, Weiler S, Tillmanns J, Egerer-Sieber C, Decker A, Lenac Roviš T, Eichler J, Sticht H, Marschall M, Muller YA.
J Biol Chem. (2022 Mar)298:101625
DOI: 10.1016/j.jbc.2022.101625  |   PUBMED: 35074430  |   IF(2018) = 4.1
PDB [P14]:  7PAB   

512: Structural and biophysical studies of new L-asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn-amidohydrolase.
Loch JI, Klonecka A, Kądziołka K, Bonarek P, Barciszewski J, Imiolczyk B, Brzezinski K, Gilski M, Jaskolski M.
Acta Crystallogr D Struct Biol. (2022 Jul)78:911-926
DOI: 10.1107/s2059798322005691  |   PUBMED: 35775990  |   IF(2018) = 3.2
PDB [P13]:  7QYM  7QY6  7QYX   

511: Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.
Bisiak F, Chrenková A, Zhang SD, Pedersen JN, Otzen DE, Zhang YE, Brodersen DE.
J Biol Chem. (2022 Jun)UNK:102142
DOI: 10.1016/j.jbc.2022.102142  |   PUBMED: 35714769  |   IF(2018) = 4.1
PDB [P13P14]:  7QOE  7QOC  7QOD   

510: Crystal structures of the molecular class A β-lactamase TEM-171 and its complexes with tazobactam.
Grigorenko VG, Petrova TE, Carolan C, Rubtsova MY, Uporov IV, Pereira J, Chojnowski G, Samygina VR, Lamzin VS, Egorov AM.
Acta Crystallogr D Struct Biol. (2022 Jul)78:825-834
DOI: 10.1107/s2059798322004879  |   PUBMED: 35775982  |   IF(2018) = 3.2
PDB [P14]:  7QOR   

509: Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803.
Malecki PH, Imiolczyk B, Barciszewski J, Czyrko-Horczak J, Sliwiak J, Gawel M, Wozniak K, Jaskolski M, Brzezinski K.
Acta Crystallogr D Struct Biol. (2022 Jul)78:865-882
DOI: 10.1107/s2059798322005605  |   PUBMED: 35775986  |   IF(2018) = 3.2
PDB [P13]:  7ZD7  7ZD8  7ZD9   

508: Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors.
Burastero O, Defelipe LA, Gola G, Tateosian NL, Lopez ED, Martinena CB, Arcon JP, Traian MD, Wetzler DE, Bento I, Barril X, Ramirez J, Marti MA, Garcia-Alai MM, Turjanski AG.
J Med Chem. (2022 Jun)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c02012  |   PUBMED: 35737472  |   IF(2018) = 6.1
PDB [P14]:  7Q52   

507: New aspects of DNA recognition by group II WRKY transcription factor revealed by structural and functional study of AtWRKY18 DNA binding domain.
Grzechowiak M, Ruszkowska A, Sliwiak J, Urbanowicz A, Jaskolski M, Ruszkowski M.
Int J Biol Macromol. (2022 Jun)213:589-601
DOI: 10.1016/j.ijbiomac.2022.05.186  |   PUBMED: 35660042  |   IF(2018) = 4.8
PDB [P14]:  7Z0U  7Z0R   

506: Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1.
Sutinen A, Nguyen GTT, Raasakka A, Muruganandam G, Loris R, Ylikallio E, Tyynismaa H, Bartesaghi L, Ruskamo S, Kursula P.
FEBS Open Bio. (2022 May)UNK:pp. UNK
DOI: 10.1002/2211-5463.13422  |   PUBMED: 35509130
PDB [P13]:  7YWD   

505: Direct interaction of a chaperone-bound type III secretion substrate with the export gate.
Gilzer D, Schreiner M, Niemann HH.
Nat Commun. (2022 Jun)13:2858
DOI: 10.1038/s41467-022-30487-1  |   PUBMED: 35654781  |   IF(2022) = 14.9
PDB [P13]:  7QIJ   

504: Ligandability Assessment of Human Glutathione Transferase M1-1 Using Pesticides as Chemical Probes.
Bodourian CS, Poudel N, Papageorgiou AC, Antoniadi M, Georgakis ND, Abe H, Labrou NE.
Int J Mol Sci. (2022 Mar)23:3606
DOI: 10.3390/ijms23073606  |   PUBMED: 35408962  |   IF(2018) = 4.2
PDB [P13]:  7BEU   

503: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
Detry S, Andries J, Bloch Y, Gabay C, Clancy DM, Savvides SN
J Biol Chem. (2022 Apr)298:101908
DOI: 10.1016/j.jbc.2022.101908  |   PUBMED: 35398099  |   IF(2018) = 4.1
PDB [-P14]:  7AL7   

502: A GH115 α-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis.
Wilkens C, Vuillemin M, Pilgaard B, Polikarpov I, Morth JP.
Acta Crystallogr D Struct Biol. (2022 May)78:658-668
DOI: 10.1107/s2059798322003527  |   PUBMED: 35503213  |   IF(2018) = 3.2
PDB [P14]:  7PUG   

501: Family 1 Glycosyltransferase UGT706F8 from Zea mays Selectively Catalyzes the Synthesis of Silibinin 7-O-β-d-Glucoside.
Bidart GN, Putkaradze N, Fredslund F, Kjeldsen C, Ruiz AG, Duus JØ, Teze D, Welner DH.
ACS Sustain Chem Eng. (2022 Apr)10:5078-5083
DOI: 10.1021/acssuschemeng.1c07593  |   PUBMED: 35493695
PDB [P14]:  7Q3S   

500: Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.
Balandis B, Šimkūnas T, Paketurytė-Latvė V, Michailovienė V, Mickevičiūtė A, Manakova E, Gražulis S, Belyakov S, Kairys V, Mickevičius V, Zubrienė A, Matulis D.
Pharmaceuticals. (Basel) (2022 Apr)15:477
DOI: 10.3390/ph15040477  |   PUBMED: 35455474
PDB [P13]:  7QGX  7QGZ   

499: Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling.
Dubovskii PV, Dubova KM, Bourenkov G, Starkov VG, Konshina AG, Efremov RG, Utkin YN, Samygina VR.
Toxins. (Basel) (2022 Feb)14:149
DOI: 10.3390/toxins14020149  |   PUBMED: 35202176
PDB [P14]:  7QFC   

498: Letter to the editor: The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein.
Struwe MA, Clement B, Scheidig A.
Hepatol Commun. (2022 May)UNK:pp. UNK
DOI: 10.1002/hep4.1984  |   PUBMED: 35560545
PDB [P14]:  7P41   

497: Binding of VIVO2+, VIVOL+, VIVOL2 and VVO2L moieties to proteins: X-ray/theoretical characterization and biological implications.
Santos MFA, Sciortino G, Correia I, Fernandes ACP, Santos-Silva T, Pisanu F, Garribba E, Pessoa JC.
Chemistry. (2022 Apr)UNK:pp. UNK
DOI: 10.1002/chem.202200105  |   PUBMED: 35486702  |   IF(2019) = 4.9
PDB [P13]:  7Q0W   

496: Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5′-monophosphate decarboxylase catalysis
Rindfleisch S, Krull M, Uranga J, et al. , Tittmann K
Nat Catal. 5: 332-341 (2022)
DOI: 10.1038/s41929-022-00771-w  |   PUBMED:   |   IF(2021) = 47.2
PDB [P13P14]:  7AM9  6YVL  6YVM  6YVK  6YVN  7ASQ  7OQI  7OUZ  7OTU  7OQK  7OQN  7OV0  7OQM  6ZX0  6ZX1  6YVO  6YWU  6ZX3  6ZX2  6YWT  6ZWY  6ZWZ  7OQF  7Q1H   

495: The Structure of Bilirubin Oxidase from Bacillus pumilus Reveals a Unique Disulfide Bond for Site-Specific Direct Electron Transfer.
Gihaz S, Herzallh NS, Cohen Y, Bachar O, Fishman A, Yehezkeli O.
Biosensors. (Basel) (2022 Apr)12:258
DOI: 10.3390/bios12050258  |   PUBMED: 35624560
PDB [P14]:  7Z5P   

494: Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Pazicky S, Werle AA, Lei J, Löw C, Weininger U.
Cell Mol Life Sci. (2022 Feb)79:138
DOI: 10.1007/s00018-022-04179-4  |   PUBMED: 35184231  |   IF(2018) = 7.0
PDB [P13]:  7OXI  7OXK  7OXG  7OXJ  7OXH   

493: A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function.
Minadakis MP, Mavreas KF, Neofytos DD, Paschou M, Kogkaki A, Athanasiou V, Mamais M, Veclani D, Iatrou H, Venturini A, Chrysina ED, Papazafiri P, Gimisis T.
Org Biomol Chem. (2022 Mar)20:2407-2423
DOI: 10.1039/d1ob02211c  |   PUBMED: 35119451
PDB [P13]:  7Q5I   

492: GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Kroef V, Ruegenberg S, Horn M, Allmeroth K, Ebert L, Bozkus S, Miethe S, Elling U, Schermer B, Baumann U, Denzel MS.
Elife. (2022 Mar)11:pp. UNK
DOI: 10.7554/elife.69223  |   PUBMED: 35229715  |   IF(2018) = 7.6
PDB [P13]:  7NUU   

491: Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations.
Sonani RR, Blat A, Dubin G.
Int J Biol Macromol. (2022 Feb)205:203-210
DOI: 10.1016/j.ijbiomac.2022.02.008  |   PUBMED: 35149097  |   IF(2018) = 4.8
PDB [P13]:  7Q84   

490: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis.
Albert L, Nagpal J, Steinchen W, Zhang L, Werel L, Djokovic N, Ruzic D, Hoffarth M, Xu J, Kaspareit J, Abendroth F, Royant A, Bange G, Nikolic K, Ryu S, Dou Y, Essen LO, Vázquez O.
ACS Cent Sci. (2022 Jan)8:57-66
DOI: 10.1021/acscentsci.1c00434  |   PUBMED: 35106373
PDB [P13]:  7AXP   

489: Structural and Functional Characterization of Camelus dromedarius Glutathione Transferase M1-1.
Perperopoulou F, Poudel N, Papageorgiou AC, Ataya FS, Labrou NE.
Life. (Basel) (2022 Jan)12:pp. UNK
DOI: 10.3390/life12010106  |   PUBMED: 35054499
PDB [P13]:  7OPY  7OPZ   

488: Rare by Natural Selection: Disulfide-Bonded Supramolecular Antimicrobial Peptides.
Engelberg Y, Ragonis-Bachar P, Landau M.
Biomacromolecules. (2022 Jan)UNK:pp. UNK
DOI: 10.1021/acs.biomac.1c01353  |   PUBMED: 35061360
PDB [P14]:  7NPQ   

487: Identification of molecular basis that underlie enzymatic specificity of AzoRo from Rhodococcus opacus 1CP: A potential NADH:quinone oxidoreductase.
Ngo ACR, Qi J, Juric C, Bento I, Tischler D.
Arch Biochem Biophys. (2022 Mar)717:109123
DOI: 10.1016/j.abb.2022.109123  |   PUBMED: 35051387
PDB [P13]:  7AWV   

486: Widespread occurrence of covalent lysine-cysteine redox switches in proteins.
Rabe von Pappenheim F, Wensien M, Ye J, Uranga J, Irisarri I, de Vries J, Funk LM, Mata RA, Tittmann K.
Nat Chem Biol. (2022 Feb)UNK:pp. UNK
DOI: 10.1038/s41589-021-00966-5  |   PUBMED: 35165445  |   IF(2020) = 41.8
PDB [P14]:  7ODO  7ODQ  7O9G  7ODP  7OEY   

485: Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2.
Mpakali A, Georgiadis D, Stratikos E, Giastas P.
ACS Med Chem Lett. (2022 Feb)13:218-224
DOI: 10.1021/acsmedchemlett.1c00582  |   PUBMED: 35178178  |   IF(2018) = 3.7
PDB [P13]:  7P7P  7PFS   

484: A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat.
Geerds C, Bleymüller WM, Meyer T, Widmann C, Niemann HH.
Acta Crystallogr D Struct Biol. (2022 Mar)78:310-320
DOI: 10.1107/s2059798322000432  |   PUBMED: 35234145  |   IF(2018) = 3.2
PDB [P13]:  7PV9   

483: Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.
Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A.
PLoS Pathog. (2022 Jan)18:e1010166
DOI: 10.1371/journal.ppat.1010166  |   PUBMED: 35007292  |   IF(2018) = 6.1
PDB [P13]:  6T5I   

482: Best practices for time-resolved serial synchrotron crystallography.
Schulz EC, Yorke BA, Pearson AR, Mehrabi P.
Acta Crystallogr D Struct Biol. 2022;78(Pt 1):14-29.
DOI: 10.1107/S2059798321011621  |   PUBMED: 34981758  |   IF(2018) = 3.2
PDB [P14]:   

Number of publications for 2022: 78

2021

481: Structure, dynamics, and function of SrnR, a transcription factor for nickel-dependent gene expression.
Mazzei L, Musiani F, Żerko S, Koźminski W, Cianci M, Beniamino Y, Ciurli S, Zambelli B.
Metallomics (2021 Dec)13:mfab069
DOI: 10.1093/mtomcs/mfab069  |   PUBMED: 34850061
PDB [P13]:  7P6F   

480: The Bacteroidetes Aequorivita sp. and Kaistella jeonii Produce Promiscuous Esterases With PET-Hydrolyzing Activity.
Zhang H, Perez-Garcia P, Dierkes RF, Applegate V, Schumacher J, Chibani CM, Sternagel S, Preuss L, Weigert S, Schmeisser C, Danso D, Pleiss J, Almeida A, Höcker B, Hallam SJ, Schmitz RA, Smits SHJ, Chow J, Streit WR.
Front Microbiol (2021 )12:803896
DOI: 10.3389/fmicb.2021.803896  |   PUBMED: 35069509  |   IF(2019) = 4.2
PDB [P13]:  7PZJ   

479: Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX.
Zakšauskas A, Čapkauskaitė E, Paketurytė-Latvė V, Smirnov A, Leitans J, Kazaks A, Dvinskis E, Stančaitis L, Mickevičiūtė A, Jachno J, Jezepčikas L, Linkuvienė V, Sakalauskas A, Manakova E, Gražulis S, Matulienė J, Tars K, Matulis D.
Int J Mol Sci (2021 Dec)23:pp. UNK
DOI: 10.3390/ijms23010130  |   PUBMED: 35008553
PDB [P13P14]:  7Q0D  7PUU  7PUW  7Q0E  7PUV  7Q0C   

478: Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii
Marchetti GM, Fusser F, Singh RK, Brummel M, Koch O, Kummel D, Hippler M
J Struct Biol (2021 Dec)214:107829
DOI: 10.1016/j.jsb.2021.107829  |   PUBMED: 34974142  |   IF(2018) = 3.8
PDB [P13]:  7P9D  7P9E   

477: Broken symmetry between RNA enantiomers in a crystal lattice.
Kiliszek A, Błaszczyk L, Bejger M, Rypniewski W.
Nucleic Acids Res (2021 Jun)UNK:pp. UNK
DOI: 10.1093/nar/gkab480  |   PUBMED: 34107036
PDB [P13]:  7A9T  7A9O  6ZWU  6ZPF  6ZX5  6ZR1  6ZRL  6ZQ9  6ZW3  6ZRS  7A9N   

476: Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Ornik-Cha A, Wilhelm J, Kobylka J, Sjuts H, Vargiu AV, Malloci G, Reitz J, Seybert A, Frangakis AS, Pos KM.
Nat Commun. (2021 Nov)12:6919
DOI: 10.1038/s41467-021-27146-2  |   PUBMED: 34824229  |   IF(2022) = 14.9
PDB [P13P14]:  7B8R  7B8S   

475: Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP.
J Med Chem (2021 Nov)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c00804  |   PUBMED: 34807584
PDB [P13]:  6YAT   

474: The elusive Rhizobium etli L-asparaginase has a novel fold and peculiar active site
Loch JI, Imiolczyk B, Sliwiak J, Wantuch A, Bejger M, Gilski M, Jaskolski M
Nat Commun. (2021 Nov)12:6717
DOI: 10.1038/s41467-021-27105-x  |   PUBMED: 34795296  |   IF(2022) = 14.9
PDB [P13]:  7OS5  7OS3  7OS6   

473: Role of hydrogen bond alternation and charge transfer states in photoactivation of the Orange Carotenoid Protein.
Yaroshevich IA, Maksimov EG, Sluchanko NN, Zlenko DV, Stepanov AV, Slutskaya EA, Slonimskiy YB, Botnarevskii VS, Remeeva A, Gushchin I, Kovalev K, Gordeliy VI, Shelaev IV, Gostev FE, Khakhulin D, Poddubnyy VV, Gostev TS, Cherepanov DA, Polívka T, Kloz M, Friedrich T, Paschenko VZ, Nadtochenko VA, Rubin AB, Kirpichnikov MP.
Communications Biology. 2021 May;4(1):539.
DOI: 10.1038/s42003-021-02022-3.  |   PUBMED: 33972665
PDB [P14]:  6T6O  6T6M  6T6K   

472: Homogeneous batch micro-crystallization of proteins from ammonium sulfate.
Stohrer C, Horrell S, Meier S, et al.
Acta crystallographica. Section D, Structural Biology. 2021 Feb;77(Pt 2):194-204.
DOI: 10.1107/s2059798320015454.  |   PUBMED: 33559608; PMCID: PMC7869895.
PDB [P14]:   

471: DYW domain structures imply an unusual regulation principle in plant organellarRNA editing catalysis.
Takenaka M, Takenaka S, Barthel T, Frink B, Haag S, Verbitskiy D, Oldenkott B, Schallenberg-Rudinger M, Feiler CG, Weiss MS, Palm GJ, Weber G,
Nat Catal. 2021 Jun;4(6):510-522. doi: 10.1038/s41929-021-00633-x. Epub 2021 Jun 21.
DOI: 10.1038/s41929-021-00633-x [doi]  |   PUBMED: 34712911  |   IF(2021) = 47.2
PDB [P13]:   

470: Conformational interplay in hybrid peptide-helical aromatic foldamer macrocycles.
Dengler S, Mandal PK, Allmendinger L, Douat C, Huc I,
Chem Sci. 2021 Jul 27;12(33):11004-11012. doi: 10.1039/d1sc03640h. eCollection2021 Aug 25.
DOI: 10.1039/d1sc03640h [doi]  |   PUBMED: 3452229
PDB [P13]:   

469: Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C.
Wallerstein J, Ekberg V, Ignjatovic MM, Kumar R, Caldararu O, Peterson K, Wernersson S, Brath U, Leffler H, Oksanen E, Logan DT, Nilsson UJ, Ryde U, Akke M,
JACS Au. 2021 Apr 1;1(4):484-500. doi: 10.1021/jacsau.0c00094. eCollection 2021Apr 26.
DOI: 10.1021/jacsau.0c00094 [doi]  |   PUBMED: 34467311
PDB [P13]:  6RZF  6RZG  6RZH   

468: Structural Characterization of EnpA D,L-Endopeptidase from Enterococcus faecalis Prophage Provides Insights into Substrate Specificity of M23 Peptidases.
Malecki PH, Mitkowski P, Jagielska E, Trochimiak K, Mesnage S, Sabala I,
Int J Mol Sci. 2021 Jul 1;22(13). pii: ijms22137136. doi: 10.3390/ijms22137136.
DOI: 10.3390/ijms22137136  |   PUBMED: 34281200  |   IF(2018) = 4.2
PDB [P13]:  6SMK   

467: Calmodulin complexes with brain and muscle creatine kinase peptides.
Sprenger J, Trifan A, Patel N, Vanderbeck A, Bredfelt J, Tajkhorshid E, Rowlett R, Lo Leggio L, Akerfeldt KS, Linse S,
Curr Res Struct Biol. 2021 May 19;3:121-132. doi: 10.1016/j.crstbi.2021.05.001.eCollection 2021.
DOI: 10.1016/j.crstbi.2021.05.001 [doi]  |   PUBMED: 34235492
PDB [P13P14]:   

466: Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase.
Nowacka M, Nowak E, Czarnocki-Cieciura M, Jackiewicz J, Skowronek K, Szczepanowski RH, Wohrl BM, Nowotny M,
J Virol. 2021 Aug 25;95(18):e0084821. doi: 10.1128/JVI.00848-21. Epub 2021 Aug25.
DOI: 10.1128/JVI.00848-21 [doi]  |   PUBMED: 34232702  |   IF(2018) = 4.3
PDB [P13]:  7O0G   

465: Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-NaphthalimideDerivatives as Potential Anticancer Agents.
Rykowski S, Gurda-Wozna D, Orlicka-Plocka M, Fedoruk-Wyszomirska A, Giel-Pietraszuk M, Wyszko E, Kowalczyk A, Staczek P, Bak A, Kiliszek A, Rypniewski W, Olejniczak AB,
Int J Mol Sci. 2021 Mar 9;22(5). pii: ijms22052772. doi: 10.3390/ijms22052772.
DOI: 10.3390/ijms22052772  |   PUBMED: 33803403  |   IF(2018) = 4.2
PDB [P13]:   

464: Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
Wortmann L, Bräuer N,Holton SJ, Irlbacher H, Weiske J, Lechner C, Meier R, Karén J, Siöberg CB, Pütter V, Christ CD, Ter Laak A, Lienau P, Lesche R, Nicke B, Cheung SH, Bauser M, Haegebarth A, von Nussbaum F, Mumberg D, Lemos C.
J Med Chem. 2021 Nov 11;64(21):15883-15911.
DOI: 10.1021/acs.jmedchem.1c01245.  |   PUBMED: 34699202.  |   IF(2018) = 6.1
PDB [P14]:  6YM5   

463: An automated platform for structural analysis of membrane proteins through serial crystallography.
Healey RD, Basu S, Humm AS, Leyrat C, Cong X, Golebiowski J, Dupeux F, Pica A, Granier S, Márquez JA.
Cell Rep Methods.
DOI: 10.1016/j.crmeth.2021.100102.  |   PUBMED: 34723237
PDB [P14]:  6YXD   

462: Wilavidin* - a novel member of the avidin family that forms unique biotin-binding hexamers.
Avraham O, Bayer EA, Livnah O.
FEBS J.
DOI: 10.1111/febs.16259.  |   PUBMED: 34726340  |   IF(2018) = 4.7
PDB [P13]:  7OUQ   

461: Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Dolot R, Krakowiak A, Kaczmarek R, Włodarczyk A, Pichlak M, Nawrot B.
Biochim Biophys Acta Gen Subj (2021 Nov)1865:129968
DOI: 10.1016/j.bbagen.2021.129968  |   PUBMED: 34329705
PDB [P13]:  6YPR  6YQD  6YPX   

460: Insights into Broad-Specificity Starch Modification from the Crystal Structure of Limosilactobacillus Reuteri NCC 2613 4,6-α-Glucanotransferase GtfB.
Pijning T, Gangoiti J, Te Poele EM, Börner T, Dijkhuizen L.
J Agric Food Chem. 2021 Oct 28.
DOI: 10.1021/acs.jafc.1c05657.  |   PUBMED: 34708648.
PDB [P14]:  7P38   

459: Profiling cellular diversity in sponges informs animal cell type and nervous system evolution.
Musser JM, Schippers KJ, Nickel M, Mizzon G, Kohn AB, Pape C, Ronchi P, Papadopoulos N, Tarashansky AJ, Hammel JU, Wolf F, Liang C, Hernández-Plaza A, Cantalapiedra CP, Achim K, Schieber NL, Pan L, Ruperti F, Francis WR, Vargas S, Kling S, Renkert M, Polikarpov M, Bourenkov G, Feuda R, Gaspar I, Burkhardt P, Wang B, Bork P, Beck M, Schneider TR, Kreshuk A, Wörheide G, Huerta-Cepas J, Schwab Y, Moroz LL, Arendt D.
Science. 2021 Nov 5;374(6568):717-723.
DOI: 10.1126/science.abj2949.  |   PUBMED: 34735222.  |   IF(2018) = 41.1
PDB [P14]:   

458: Structural basis of cytokine-mediated activation of ALK family receptors.
De Munck S, Provost M, Kurikawa M, Omori I, Mukohyama J, Felix J, Bloch Y, Abdel-Wahab O, Bazan JF, Yoshimi A, Savvides SN.
Nature. (2021 Oct 13). Epub ahead of print
DOI: 10.1038/s41586-021-03959-5  |   PUBMED: 34646012  |   IF(2018) = 43.1
PDB [P13P14]:  7NX4  7NX2  7NX1   

457: Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation-π interaction.
Helfrich F, Scheidig AJ.
Acta Crystallogr D Struct Biol (2021 Oct)77:1317-1335
DOI: 10.1107/s2059798321008937  |   PUBMED: 34605434  |   IF(2018) = 3.2
PDB [P13P14]:  6Y87  6SEP  6S6G  4W8G  6S49  6S4D  6S65  6S3X  6S72   

456: 3D Domain Swapping Dimerization of the Receiver Domain of Cytokinin Receptor CRE1 From Arabidopsis thaliana and Medicago truncatula.
Tran LH, Urbanowicz A, Jasiński M, Jaskolski M, Ruszkowski M.
Front Plant Sci (2021 )12:756341
DOI: 10.3389/fpls.2021.756341  |   PUBMED: 34630499  |   IF(2016) = 4.4
PDB [P13]:  7P8E  7P8D  7P8C   

455: Medicinal Au(I) compounds targeting urease as prospective antimicrobial agents: unveiling the structural basis for enzyme inhibition.
Mazzei L, Massai L, Cianci M, Messori L, Ciurli S.
Dalton Trans. 2021;50(40):14444-14452.
DOI: 10.1039/d1dt02488d  |   PUBMED: 34585201
PDB [P13]:  7P7N  7P7O   

454: Kinetic and structural analysis of the inactivation of urease by mixed-ligand phosphine halide Ag(I) complexes.
Mazzei L, Cirri D, Cianci M, Messori L, Ciurli S.
J Inorg Biochem. (2021 May)218:111375
DOI: 10.1016/j.jinorgbio.2021.111375  |   PUBMED: 33711632
PDB [P13]:  7B58  7B5A  7B59   

453: Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket.
Grininger C, Leypold M, Aschauer P, Pavkov-Keller T, Riegler-Berket L, Breinbauer R, Oberer M.
Biomolecules. (2021 Sep)11:pp. UNK
DOI: 10.3390/biom11091299  |   PUBMED: 34572512  |   IF(2019) = 4.7
PDB [P13]:  7OZM   

452: The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes.
Osorio-Valeriano M, Altegoer F, Das CK, Steinchen W, Panis G, Connolley L, Giacomelli G, Feddersen H, Corrales-Guerrero L, Giammarinaro PI, Hanßmann J, Bramkamp M, Viollier PH, Murray S, Schäfer LV, Bange G, Thanbichler M.
Mol Cell. (2021 Oct)81:3992-4007.e10
DOI: 10.1016/j.molcel.2021.09.004  |   PUBMED: 34562373  |   IF(2018) = 14.5
PDB [P14]:  7BNR   

451: Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Nair RM, Seenivasan A, Liu B, Chen D, Lowe ED, Lorenz S.
ACS Chem Biol. (2021 Sep)16:1615-1621
DOI: 10.1021/acschembio.1c00433  |   PUBMED: 34403242  |   IF(2019) = 4.43
PDB [P13]:  6XZ1   

450: Crystal structure of Z-DNA in complex with the polyamine putrescine and potassium cations at ultra-high resolution.
Drozdzal P, Gilski M, Jaskolski M.
Acta Crystallogr B Struct Sci Cryst Eng Mater. (2021 Jun)77:331-338
DOI: 10.1107/s2052520621002663  |   PUBMED: 34096514
PDB [P13]:  7ATG   

449: Considerations Regarding Activity Determinants of Fungal Polyphenol Oxidases Based on Mutational and Structural Studies.
Nikolaivits E, Valmas A, Dedes G, Topakas E, Dimarogona M.
Appl Environ Microbiol. (2021 May)87:pp. UNK
DOI: 10.1128/aem.00396-21  |   PUBMED: 33741634
PDB [P14]:  6Z1S   

448: Engineering a Highly Efficient Carboligase for Synthetic One-Carbon Metabolism.
Nattermann M, Burgener S, Pfister P, Chou A, Schulz L, Lee SH, Paczia N, Zarzycki J, Gonzalez R, Erb TJ.
ACS Catal. (2021 May)11:5396-5404
DOI: 10.1021/acscatal.1c01237  |   PUBMED: 34484855  |   IF(2018) = 12.1
PDB [P13]:  7B2E   

447: Glycogen phosphorylase revisited: extending the resolution of the R- and T-state structures of the free enzyme and in complex with allosteric activators.
Leonidas DD, Zographos SE, Tsitsanou KE, Skamnaki VT, Stravodimos G, Kyriakis E.
Acta Crystallogr F Struct Biol Commun. (2021 Sep)77:303-311
DOI: 10.1107/s2053230x21008542  |   PUBMED: 34473107  |   IF(2019) = 0.97
PDB [P13]:  7P7D   

446: Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Koelmel W, Kuper J, Kisker C.
Sci Rep. (2021 Aug)11:17038
DOI: 10.1038/s41598-021-95186-1  |   PUBMED: 34426585  |   IF(2022) = 5.0
PDB [P14]:  7BMR  7BMU  7BMO  7BMQ   

445: BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture.
Bandera AM, Bartho J, Lammens K, Drexler DJ, Kleinschwärzer J, Hopfner KP, Witte G.
Nucleic Acids Res. (2021 Sep)49:10166-10177
DOI: 10.1093/nar/gkab736  |   PUBMED: 34432045  |   IF(2018) = 11.1
PDB [P13P14]:  7B5U  7B5T  7B5W   

444: Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.
Fauser J, Gulen B, Pogenberg V, Pett C, Pourjafar-Dehkordi D, Krisp C, Höpfner D, König G, Schlüter H, Feige MJ, Zacharias M, Hedberg C, Itzen A.
Nat Commun. (2021 Apr)12:2426
DOI: 10.1038/s41467-021-22596-0  |   PUBMED: 33893288  |   IF(2022) = 14.9
PDB [P13]:  6ZMD   

443: Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli.
Hamborg L, Granata D, Olsen JG, Roche JV, Pedersen LE, Nielsen AT, Lindorff-Larsen K, Teilum K.
Commun Biol. (2021 Aug)4:980
DOI: 10.1038/s42003-021-02490-7  |   PUBMED: 34408246  |   IF(2019) = 12.1
PDB [P13P14]:  7A3M  7AON  7AOK   

442: Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.
Masuyer G, Davies JR, Stenmark P.
Int J Mol Sci. (2021 Aug)22:pp. UNK
DOI: 10.3390/ijms22158315  |   PUBMED: 34361086  |   IF(2018) = 4.2
PDB [P13]:  7OVW   

441: Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria.
Freischem S, Grimm I, López-Pérez A, Willbold D, Klenke B, Vuong C, Dingley AJ, Weiergräber OH.
Biomolecules. (2021 Jul)11:pp. UNK
DOI: 10.3390/biom11071057  |   PUBMED: 34356681  |   IF(2019) = 4.7
PDB [P13]:  7ONY  7ONZ   

440: Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA.
Blersch KF, Burchert JP, August SC, Welp L, Neumann P, Köster S, Urlaub H, Ficner R.
RNA Biol. (2021 May)UNK:1-14
DOI: 10.1080/15476286.2021.1925477  |   PUBMED: 34006170
PDB [P13]:  7NZJ  7NYB   

439: Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers.
Schweininger J, Scherer M, Rothemund F, Schilling EM, Wörz S, Stamminger T, Muller YA.
PLoS Pathog. (2021 Aug)17:e1009863
DOI: 10.1371/journal.ppat.1009863  |   PUBMED: 34370791  |   IF(2018) = 6.1
PDB [P13]:  6TGZ   

438: Structure and mechanism of secondary sulfonamide binding to carbonic anhydrases.
Baronas D, Dudutienė V, Paketurytė V, Kairys V, Smirnov A, Juozapaitienė V, Vaškevičius A, Manakova E, Gražulis S, Zubrienė A, Matulis D.
Eur Biophys J. (2021 Jul)UNK:pp. UNK
DOI: 10.1007/s00249-021-01561-1  |   PUBMED: 34328515
PDB [P13P14]:  7AES  7AEQ  7AGN   

437: Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.
Uusitalo M, Klenow MB, Laulumaa S, Blakeley MP, Simonsen AC, Ruskamo S, Kursula P.
FEBS J. (2021 Jun)UNK:pp. UNK
DOI: 10.1111/febs.16079  |   PUBMED: 34138518  |   IF(2018) = 4.7
PDB [P13]:  7NRW   

436: Conformational changes of loops highlight a potential binding site in Rhodococcus equi VapB.
Geerds C, Haas A, Niemann HH.
Acta Crystallogr F Struct Biol Commun. (2021 Aug)77:246-253
DOI: 10.1107/s2053230x2100738x  |   PUBMED: 34341190  |   IF(2019) = 0.97
PDB [P14]:  7B1Z   

435: Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis β-oxidation trifunctional enzyme.
Dalwani S, Lampela O, Leprovost P, Schmitz W, Juffer AH, Wierenga RK, Venkatesan R.
J Struct Biol. (2021 Aug)213:107776
DOI: 10.1016/j.jsb.2021.107776  |   PUBMED: 34371166  |   IF(2018) = 3.8
PDB [P13]:  7O4T   

434: The induction mechanism of the flavonoid-responsive regulator FrrA.
Werner N, Werten S, Hoppen J, Palm GJ, Göttfert M, Hinrichs W.
FEBS J. (2021 Jul)UNK:pp. UNK
DOI: 10.1111/febs.16141  |   PUBMED: 34314575  |   IF(2018) = 4.7
PDB [P13]:  6G8H  6G8G   

433: NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
Baggio C, Kulinich A, Dennys CN, Rodrigo R, Meyer K, Ethell I, Pellecchia M.
J Med Chem. (2021 Jul)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c00608  |   PUBMED: 34293864  |   IF(2018) = 6.1
PDB [P13]:  7OFV   

432: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Verstraete K, Verschueren KHG, Dansercoer A, Savvides SN.
Nat Struct Mol Biol. 2021 Aug;28(8):636-638. Epub 2021 Jul 22.
DOI: 10.1038/s41594-021-00624-3  |   PUBMED: 34294920  |   IF(2019) = 11.7
PDB [P14]:  6ZNW   

431: Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography.
Geier B, Oetjen J, Ruthensteiner B, Polikarpov M, Gruber-Vodicka HR, Liebeke M.
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2023773118.
DOI: 10.1073/pnas.2023773118.  |   PUBMED: 34183413   |   IF(2019) = 9.4
PDB [P14]:   

430: Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps.
Kelpšas V, Caldararu O, Blakeley MP, Coquelle N, Wierenga RK, Ryde U, von Wachenfeldt C, Oksanen E.
IUCrJ. (2021 Jul)8:633-643
DOI: 10.1107/s2052252521004619  |   PUBMED: 34258011  |   IF(2020) = 4
PDB [P14]:  7AZ9  7AZA   

429: Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii.
Krska D, Mazurkewich S, Brown HA, Theibich Y, Poulsen JN, Morris AL, Koropatkin NM, Lo Leggio L, Larsbrink J.
Biochemistry. (2021 Jul)60:2206-2220
DOI: 10.1021/acs.biochem.1c00305  |   PUBMED: 34180241  |   IF(2018) = 3.0
PDB [P13]:  7NWO  7NWQ   

428: Insights into the Protein Ruthenation Mechanism by Antimetastatic Metallodrugs: High-Resolution X-ray Structures of the Adduct Formed between Hen Egg-White Lysozyme and NAMI-A at Various Time Points.
Chiniadis L, Giastas P, Bratsos I, Papakyriakou A.
Inorg Chem. (2021 Jul)60:10729-10737
DOI: 10.1021/acs.inorgchem.1c01441  |   PUBMED: 34197115  |   IF(2019) = 4
PDB [P13]:  7BCX  7BD0  7BDM  7BCU   

427: Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners.
Marcelot A, Petitalot A, Ropars V, Le Du MH, Samson C, Dubois S, Hoffmann G, Miron S, Cuniasse P, Marquez JA, Thai R, Theillet FX, Zinn-Justin S.
Nucleic Acids Res. (2021 Apr)49:3841-3855
DOI: 10.1093/nar/gkab184  |   PUBMED: 33744941  |   IF(2018) = 11.1
PDB [P14]:  7ABM   

426: A computationally designed β-amino acid-containing miniprotein.
Bejger M, Fortuna P, Drewniak-Switalska M, Plewka J, Rypniewski W, Berlicki Ł.
Chem Commun. (Camb) (2021 Jun)57:6015-6018
DOI: 10.1039/d1cc02192c  |   PUBMED: 34032224  |   IF(2019) = 5.996
PDB [P13]:  7ARR  7ARS   

425: Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan.
Sprenger J, Lawson CL, von Wachenfeldt C, Lo Leggio L, Carey J.
Acta Crystallogr F Struct Biol Commun. (2021 Jul)77:215-225
DOI: 10.1107/s2053230x21006142  |   PUBMED: 34196612  |   IF(2019) = 0.97
PDB [P13]:  7OS9   

424: Snapshots of a Non-Canonical RdRP in Action.
Ferrero DS, Falqui M, Verdaguer N.
Viruses. (2021 Jun)13:pp. UNK
DOI: 10.3390/v13071260  |   PUBMED: 34203380  |   IF(2020) = 5.048
PDB [P13]:  7OMA  7OM7   

423: Structure of the mycobacterial ESX-5 type VII secretion system pore complex.
Beckham KSH, Ritter C, Chojnowski G, Ziemianowicz DS, Mullapudi E, Rettel M, Savitski MM, Mortensen SA, Kosinski J, Wilmanns M.
Sci Adv. 2021 Jun 25;7(26):eabg9923.
DOI: 10.1126/sciadv.abg9923  |   PUBMED: 34172453  |   IF(2018) = 12.5
PDB [P13]:  7B7J   

422: Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1.
Orth B, Sander B, Möglich A, Diederichs K, Eilers M, Lorenz S.
Structure. (2021 Jun)UNK:pp. UNK
DOI: 10.1016/j.str.2021.06.005  |   PUBMED: 34186024  |   IF(2022) = 5.0
PDB [P13]:  7AZW   

421: Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.
Samarina N, Ssebyatika G, Tikla T, Waldmann JY, Abere B, Nanna V, Marasco M, Carlomagno T, Krey T, Schulz TF.
PLoS Pathog. (2021 Jun)17:e1009635
DOI: 10.1371/journal.ppat.1009635  |   PUBMED: 34143834  |   IF(2018) = 6.1
PDB [P13]:  7NXE   

420: Allosteric drug transport mechanism of multidrug transporter AcrB.
Tam HK, Foong WE, Oswald C, Herrmann A, Zeng H, Pos KM.
Nat Commun. (2021 Jun)12:3889
DOI: 10.1038/s41467-021-24151-3  |   PUBMED: 34188038  |   IF(2022) = 14.9
PDB [P13]:  6ZOG   

419: Discovery of fungal surface NADases predominantly present in pathogenic species.
Strømland Ø, Kallio JP, Pschibul A, Skoge RH, Harðardóttir HM, Sverkeli LJ, Heinekamp T, Kniemeyer O, Migaud M, Makarov MV, Gossmann TI, Brakhage AA, Ziegler M.
Nat Commun. (2021 Mar)12:1631
DOI: 10.1038/s41467-021-21307-z  |   PUBMED: 33712585  |   IF(2022) = 14.9
PDB [P13]:  6YGE   

418: Mutation-induced dimerization of transforming growth factor-β-induced protein may drive protein aggregation in granular corneal dystrophy.
Nielsen NS, Gadeberg TAF, Poulsen ET, Harwood SL, Weberskov CE, Pedersen JS, Andersen GR, Enghild JJ.
J Biol Chem. (2021 Jun)297:100858
DOI: 10.1016/j.jbc.2021.100858  |   PUBMED: 34097874  |   IF(2018) = 4.1
PDB [P13P14]:  7AS7  7ASC  7ASG   

417: Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2.
Czapinska H, Winiewska-Szajewska M, Szymaniec-Rutkowska A, Piasecka A, Bochtler M, Poznański J.
J Phys Chem B. (2021 Mar)125:2491-2503
DOI: 10.1021/acs.jpcb.0c10264  |   PUBMED: 33689348
PDB [P14]:  6TLU  6TLS  6TLV  6TLL  6TLO  6TLR  6TLW   

416: Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin.
Sponga A, Arolas JL, Schwarz TC, Jeffries CM, Rodriguez Chamorro A, Kostan J, Ghisleni A, Drepper F, Polyansky A, De Almeida Ribeiro E, Pedron M, Zawadzka-Kazimierczuk A, Mlynek G, Peterbauer T, Doto P, Schreiner C, Hollerl E, Mateos B, Geist L, Faulkner G, Kozminski W, Svergun DI, Warscheid B, Zagrovic B, Gautel M, Konrat R, Djinović-Carugo K.
Sci Adv. 2021 May 28; 7(22):eabg7653.
DOI: 10.1126/sciadv.abg7653  |   PUBMED: 34049882  |   IF(2018) = 12.5
PDB [P14]:  7A8T   

415: Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Sekulovski S, Devant P, Panizza S, Gogakos T, Pitiriciu A, Heitmeier K, Ramsay EP, Barth M, Schmidt C, Tuschl T, Baas F, Weitzer S, Martinez J, Trowitzsch S.
Nat Commun. 2021 Sep 28;12(1):5610.
DOI: 10.1038/s41467-021-25870-3  |   PUBMED: 34584079  |   IF(2022) = 14.9
PDB [P14]:  6Z9U   

414: Low Carbon Footprint Recycling of Post-Consumer PET Plastic with a Metagenomic Polyester Hydrolase.
Sonnendecker C, Oeser J, Richter PK, Hille P, Zhao Z, Fischer C, Lippold H, Blázquez-Sánchez P, Engelberger F, Ramírez-Sarmiento CA, Oeser T, Lihanova Y, Frank R, Jahnke HG, Billig S, Abel B, Sträter N, Matysik J, Zimmermann W.
ChemSusChem. (2021 Jun)UNK:pp. UNK
DOI: 10.1002/cssc.202101062  |   PUBMED: 34129279  |   IF(2019) = 7.692
PDB [P14]:  7NEI   

413: Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
Nguyen D, Xie X, Jakobi S, Terwesten F, Metz A, Nguyen TXP, Palchykov VA, Heine A, Reuter K, Klebe G.
ACS Chem Biol. (2021 Jun)16:1090-1098
DOI: 10.1021/acschembio.1c00296  |   PUBMED: 34081441  |   IF(2019) = 4.43
PDB [P13P14]:  7A4X  7ADN   

412: A simple vapor-diffusion method enables protein crystallization inside the HARE serial crystallography chip.
Norton-Baker B, Mehrabi P, Boger J, Schönherr R, von Stetten D, Schikora H, Kwok AO, Martin RW, Miller RJD, Redecke L, Schulz EC.
Acta Crystallogr D Struct Biol. (2021 Jun)77:820-834
DOI: 10.1107/s2059798321003855  |   PUBMED: 34076595  |   IF(2018) = 3.2
PDB [P14]:  7NJH  7NJG  7NJJ  7NJI  7NJE  7NKF  7NJF   

411: Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum.
Švecová L, Østergaard LH, Skálová T, Schnorr KM, Koval' T, Kolenko P, Stránský J, Sedlák D, Dušková J, Trundová M, Hašek J, Dohnálek J.
Acta Crystallogr D Struct Biol. (2021 Jun)77:755-775
DOI: 10.1107/s2059798321003533  |   PUBMED: 34076590  |   IF(2018) = 3.2
PDB [P13]:  7AA2  6ZE5  6ZE2   

410: Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent.
Narczyk M, Mioduszewski Ł, Oksiejuk A, Winiewska-Szajewska M, Wielgus-Kutrowska B, Gojdź A, Cieśla J, Bzowska A.
Sci Rep. (2021 May)11:11144
DOI: 10.1038/s41598-021-90472-4  |   PUBMED: 34045551  |   IF(2022) = 5.0
PDB [P14]:  6XZ2   

409: Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.
Yperman K, Papageorgiou AC, Merceron R, De Munck S, Bloch Y, Eeckhout D, Jiang Q, Tack P, Grigoryan R, Evangelidis T, Van Leene J, Vincze L, Vandenabeele P, Vanhaecke F, Potocký M, De Jaeger G, Savvides SN, Tripsianes K, Pleskot R, Van Damme D.
Nat Commun. (2021 May)12:3050
DOI: 10.1038/s41467-021-23314-6  |   PUBMED: 34031427  |   IF(2022) = 14.9
PDB [P14]:  6YIG   

408: TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D.
Mol Cell. (2021 Apr)UNK:pp. UNK
DOI: 10.1016/j.molcel.2021.04.019  |   PUBMED: 33974911  |   IF(2018) = 14.5
PDB [P13]:  7A0N   

407: Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Wurm JP, Sung S, Kneuttinger AC, Hupfeld E, Sterner R, Wilmanns M, Sprangers R.
Nat Commun. (2021 May)12:2748
DOI: 10.1038/s41467-021-22968-6  |   PUBMED: 33980881  |   IF(2022) = 14.9
PDB [P13]:  7AC8   

406: A lysine-cysteine redox switch with an NOS bridge regulates enzyme function.
Wensien M, von Pappenheim FR, Funk LM, Kloskowski P, Curth U, Diederichsen U, Uranga J, Ye J, Fang P, Pan KT, Urlaub H, Mata RA, Sautner V, Tittmann K.
Nature. 2021 May;593(7859):460-464. Epub 2021 May 5.
DOI: 10.1038/s41586-021-03513-3  |   PUBMED: 33953398  |   IF(2018) = 43.1
PDB [P14]:  6ZWJ  7BBW  7BBX  6ZWF  6ZX4  6ZWH   

405: The crystal structure of the Ca²⁺-ATPase 1 from Listeria monocytogenes reveals a pump primed for dephosphorylation.
Basse Hansen S, Dyla M, Neumann C, Meldgaard Hoegh Quistgaard E, Lauwring Andersen J, Kjaergaard M, Nissen P.
J Mol Biol. (2021 Apr)UNK:167015
DOI: 10.1016/j.jmb.2021.167015  |   PUBMED: 33933469  |   IF(2018) = 5.1
PDB [P13]:  6ZHH  6ZHG   

404: The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan.
Imae R, Kuwabara N, Manya H, Tanaka T, Tsuyuguchi M, Mizuno M, Endo T, Kato R.
Genes Cells. (2021 Apr)UNK:pp. UNK
DOI: 10.1111/gtc.12853  |   PUBMED: 33893702  |   IF(2019) = 1.65
PDB [P14]:  7E9K   

403: Serendipitous crystallization of E. coli HPII catalase, a sequel to "the tale usually not told".
Grzechowiak M, Sekula B, Jaskolski M, Ruszkowski M.
Acta Biochim Pol. (2021 Jan) 68:29-31
DOI: 10.18388/abp.2020_5501  |   PUBMED: 33485289
PDB [P13]:  6ZTV  6ZTW   

402: X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schluenzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A.
Science. (2021 May 7) 372(6542):642-646
DOI: 10.1126/science.abf7945  |   PUBMED: 33811162  |   IF(2018) = 41.1
PDB [P14]:  7AXO   

401: Crystal structures of the EVE-HNH endonuclease VcaM4I in the presence and absence of DNA.
Pastor M, Czapinska H, Helbrecht I, Krakowska K, Lutz T, Xu SY, Bochtler M.
Nucleic Acids Res. (2021 Feb)49:1708-1723
DOI: 10.1093/nar/gkaa1218  |   PUBMED: 33450012  |   IF(2018) = 11.1
PDB [P13]:  6YKF   

400: The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins.
Röllen K, Granzin J, Remeeva A, Davari MD, Gensch T, Nazarenko VV, Kovalev K, Bogorodskiy A, Borshchevskiy V, Hemmer S, Schwaneberg U, Gordeliy V, Jaeger KE, Batra-Safferling R, Gushchin I, Krauss U.
J Biol Chem. (2021 Apr)UNK:100662
DOI: 10.1016/j.jbc.2021.100662  |   PUBMED: 33862085  |   IF(2018) = 4.1
PDB [P13P14]:  7AB7   

399: Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison.
Mehrabi P, Bücker R, Bourenkov G, Ginn HM, von Stetten D, Müller-Werkmeister HM, Kuo A, Morizumi T, Eger BT, Ou WL, Oghbaey S, Sarracini A, Besaw JE, Pare-Labrosse O, Meier S, Schikora H, Tellkamp F, Marx A, Sherrell DA, Axford D, Owen RL, Ernst OP, Pai EF, Schulz EC, Miller RJD.
Sci Adv. (2021 Mar 17) 7(12):eabf1380
DOI: 10.1126/sciadv.abf1380  |   PUBMED: 33731353  |   IF(2018) = 12.5
PDB [P14]:  7A42  7A44   

398: Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.
Sutherland M, Li A, Kaghad A, Panagopoulos D, Li F, Szewczyk M, Smil D, Scholten C, Bouché L, Stellfeld T, Arrowsmith CH, Barsyte D, Vedadi M, Hartung IV, Steuber H, Britton R, Santhakumar V.
ChemMedChem. (2021 Apr)16:1116-1125
DOI: 10.1002/cmdc.202100018  |   PUBMED: 33513288  |   IF(2018) = 3.0
PDB [P13]:  7NR4   

397: Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII.
Smirnovienė J, Smirnov A, Zakšauskas A, Zubrienė A, Petrauskas V, Mickevičiūtė A, Michailovienė V, Čapkauskaitė E, Manakova E, Gražulis S, Baranauskienė L, Chen WY, Ladbury JE, Matulis D.
ChemistryOpen (2021 May)10:567-580
DOI: 10.1002/open.202100042  |   PUBMED: 33945229
PDB [P13]:  6YH6  6YH8  6YHB  6YH5  6YH7  6YH9  6YHA  6YH4  6YHC   

396: Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors.
Bauder M, Meyners C, Purder PL, Merz S, Sugiarto WO, Voll AM, Heymann T, Hausch F.
J Med Chem. (2021 Mar)64:3320-3349
DOI: 10.1021/acs.jmedchem.0c02195  |   PUBMED: 33666419  |   IF(2018) = 6.1
PDB [P13]:  7B9Z  7B9Y  7BA0   

395: Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A.
J Med Chem. (2021 Apr)64:4623-4661
DOI: 10.1021/acs.jmedchem.0c02094  |   PUBMED: 33818106  |   IF(2018) = 6.1
PDB [P13P14]:  6ZF4  6ZF5  6ZF7  6ZF0  6ZF1  6ZF2  6ZF3  6ZF6   

394: Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism.
Bustad HJ, Kallio JP, Laitaoja M, Toska K, Kursula I, Martinez A, Jänis J.
iScience. (2021 Mar)24:102152
DOI: 10.1016/j.isci.2021.102152  |   PUBMED: 33665570  |   IF(2020) = 4
PDB [P13P14]:  7AAJ  7AAK   

393: Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Pannecoucke E, Van Trimpont M, Desmet J, Pieters T, Reunes L, Demoen L, Vuylsteke M, Loverix S, Vandenbroucke K, Alard P, Henderikx P, Deroo S, Baatz F, Lorent E, Thiolloy S, Somers K, McGrath Y, Van Vlierberghe P, Lasters I, Savvides SN.
Sci Adv. (2021 Mar)7:pp. UNK
DOI: 10.1126/sciadv.abe1682  |   PUBMED: 33771865  |   IF(2018) = 12.5
PDB [P14]:  6ZL1   

392: Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP.
Shaikhqasem A, Schmitt K, Valerius O, Ficner R.
Acta Crystallogr F Struct Biol Commun. (2021 Mar)77:70-78
DOI: 10.1107/s2053230x2100203x  |   PUBMED: 33682791  |   IF(2019) = 0.97
PDB [P13]:  7B51   

391: Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1.
Ruegenberg S, Mayr FAMC, Atanassov I, Baumann U, Denzel MS.
Nat Commun. (2021 Apr)12:2176
DOI: 10.1038/s41467-021-22320-y  |   PUBMED: 33846315  |   IF(2022) = 14.9
PDB [P13]:  6ZMK  7NDL   

390: Structural insights into the inhibition of glycine reuptake.
Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR, Dawson RJP, Nissen P.
Nature (2021 Mar)591:677-681
DOI: 10.1038/s41586-021-03274-z  |   PUBMED: 33658720  |   IF(2018) = 43.1
PDB [P14]:  6ZPL  6ZBV   

389: The structure of Prp2 bound to RNA and ADP-BeF₃^- reveals structural features important for RNA unwinding by DEAH-box ATPases.
Hamann F, Zimmerningkat LC, Becker RA, Garbers TB, Neumann P, Hub JS, Ficner R.
Acta Crystallogr D Struct Biol. (2021 Apr)77:496-509
DOI: 10.1107/s2059798321001194  |   PUBMED: 33825710  |   IF(2018) = 3.2
PDB [P14]:  6ZM2   

388: Arresting the Catalytic Arginine in Chlorite Dismutases: Impact on Heme Coordination, Thermal Stability, and Catalysis.
Schmidt D, Serra I, Mlynek G, Pfanzagl V, Hofbauer S, Furtmüller PG, Djinović-Carugo K, Van Doorslaer S, Obinger C.
Biochemistry (2021 Mar) 60:621-634
DOI: 10.1021/acs.biochem.0c00910  |   PUBMED: 33586945  |   IF(2018) = 3.0
PDB [P13]:  7ASB  7ATI   

387: Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue.
Arkhipova V, Fu H, Hoorens MWH, Trinco G, Lameijer LN, Marin E, Feringa BL, Poelarends GJ, Szymanski W, Slotboom DJ, Guskov A.
J Am Chem Soc. (2021 Jan)143:1513-1520
DOI: 10.1021/jacs.0c11336  |   PUBMED: 33449695  |   IF(2018) = 14.7
PDB [P13]:  6ZLH  6ZGB  6ZL4   

386: Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production.
Venskutonytė R, Koh A, Stenström O, Khan MT, Lundqvist A, Akke M, Bäckhed F, Lindkvist-Petersson K.
Nat Commun. (2021 Mar)12:1347
DOI: 10.1038/s41467-021-21548-y  |   PUBMED: 33649331  |   IF(2022) = 14.9
PDB [P13]:  6T85   

385: Structural basis of Naa20 activity towards a canonical NatB substrate.
Layer D, Kopp J, Fontanillo M, Köhn M, Lapouge K, Sinning I.
Commun Biol. 2021 Jan 4;4(1):2.
DOI: 10.1038/s42003-020-01546-4.  |   PUBMED: 33398031  |   IF(2019) = 12.1
PDB [P14]:  6ZMP   

384: Structural properties and peptide ligand binding of the capsid homology domains of human Arc.
Hallin EI, Bramham CR, Kursula P.
Biochem Biophys Rep. (2021 Jul)26:100975
DOI: 10.1016/j.bbrep.2021.100975  |   PUBMED: 33732907  |   IF(2021) = 2.53
PDB [P13P14]:  6TQ0  6TNO  6TN7  6TNQ   

383: The amphibian antimicrobial peptide uperin 3.5 is a cross-α/cross-β chameleon functional amyloid
Salinas N, Tayeb-Fligelman E, Sammito MD, Bloch D, Jelinek R, Noy D, Usón I, Landau M
Proc Natl Acad Sci U S A. 118(3):e2014442118.
DOI: 10.1073/pnas.2014442118  |   PUBMED: 33431675  |   IF(2019) = 9.4
PDB [P14]:   

Number of publications for 2021: 99

2020

382: The copper(II)-binding tripeptide GHK, a valuable crystallization and phasing tag for macromolecular crystallography.
Mehr A, Henneberg F, Chari A, Görlich D, Huyton T.
Acta Crystallogr D Struct Biol. 2020 Dec 1;76(Pt 12):1222-1232.
DOI: 10.1107/S2059798320013741.  |   PUBMED: 33263328  |   IF(2018) = 3.2
PDB [P14]:   

381: RIM-binding protein couples synaptic vesicle recruitment to release sites.
Petzoldt AG, Götz TWB, Driller JH, Lützkendorf J, Reddy-Alla S, Matkovic-Rachid T, Liu S, Knoche E, Mertel S, Ugorets V, Lehmann M, Ramesh N, Beuschel CB, Kuropka B, Freund C, Stelzl U, Loll B, Liu F, Wahl MC, Sigrist SJ.
J Cell Biol. 2020 Jul 6;219(7):e201902059.
DOI: 10.1083/jcb.201902059.  |   PUBMED: 32369542  |   IF(2018) = 8.8
PDB [P14]:   

380: Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation.
Kisiala M, Kowalska M, Pastor M, Korza HJ, Czapinska H, Bochtler M.
Nucleic Acids Res. 2020 Jul 9;48(12):6954-6969.
DOI: 10.1093/nar/gkaa403.  |   PUBMED: 32459314  |   IF(2018) = 11.1
PDB [P13]:  6G3B   

379: C60 in a peptidic cage: a case of symmetry mismatch studied by crystallography and solid-state NMR.
Gilski M, Bernatowicz P, Sakowicz A, Szymański MP, Zalewska A, Szumna A, Jaskólski M
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2020 Oct 1;76(Pt 5):815-824.
DOI: 10.1107/S2052520620009944.  |   PUBMED: 33017315
PDB [P13]:   

378: Aromatic Foldamer Helices as α-Helix Extended Surface Mimetics.
Zwillinger M, Reddy PS, Wicher B, Mandal PK, Csékei M, Fischer L, Kotschy A, Huc I.
Chemistry. 2020 Dec 23;26(72):17366-17370.
DOI: 10.1002/chem.202004064. Epub 2020 Nov 30.  |   PUBMED: 32910480  |   IF(2019) = 4.9
PDB [P13]:   

377: Serial synchrotron crystallography for time-resolved structural biology.
Pearson AR, Mehrabi P.
Curr Opin Struct Biol. 2020 Dec;65:168-174.
DOI: 10.1016/j.sbi.2020.06.019.  |   PUBMED: 32846363.
PDB [P14]:   

376: The HARE chip for efficient time-resolved serial synchrotron crystallography.
Mehrabi P, Müller-Werkmeister HM, Leimkohl JP, Schikora H, Ninkovic J, Krivokuca S, Andriček L, Epp SW, Sherrell D, Owen RL, Pearson AR, Tellkamp F, Schulz EC, Miller RJD.
J Synchrotron Radiat. 2020 Mar 1;27(Pt 2):360-370.
DOI: 10.1107/S1600577520000685.  |   PUBMED: 32153274
PDB [P14]:   

375: Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif.
Eriksen MS, Nikolaienko O, Hallin EI, Grødem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuéllar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR.
FEBS J. (2020 Nov)UNK:pp. UNK
DOI: 10.1111/febs.15618  |   PUBMED: 33175445  |   IF(2018) = 4.7
PDB [P13]:  6YTU   

374: Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I.
Cell Chem Biol. (2020 Nov)27:1441-1451.e7
DOI: 10.1016/j.chembiol.2020.07.010  |   PUBMED: 32726587
PDB [P13]:  6YEK   

373: Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7.
Hanke S, Tindall CA, Pippel J, Ulbricht D, Pirotte B, Reboud-Ravaux M, Heiker JT, Sträter N.
J Med Chem. 2020 Jun 11;63(11):5723-5733.
DOI: 10.1021/acs.jmedchem.9b01806  |   PUBMED: 32374603  |   IF(2018) = 6.1
PDB [P14]:   

372: Development of PSMA-1007-Related Series of 18F-Labeled Glu-Ureido-Type PSMA Inhibitors.
Cardinale J, Roscher M, Schäfer M, Geerlings M, Benešová Bauder-Wüst U, Remde Y, Eder M, Nováková Z, Motlová L, Barinka C, Giesel FL, Kopka K.
J Med Chem. 2020 Oct 8;63(19):10897-10907.
DOI: 10.1021/acs.jmedchem.9b01479  |   PUBMED: 32852205  |   IF(2018) = 6.1
PDB [P13]:  5O5T   

371: Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Weidenhausen J, Kopp J, Armbruster L, Wirtz M, Lapouge K, Sinning I.
Structure. (2020 Dec)UNK:pp. UNK
DOI: 10.1016/j.str.2020.12.004  |   PUBMED: 33400917  |   IF(2022) = 5.0
PDB [P13]:  6Z00   

370: High-resolution structural insights into the heliorhodopsin family.
Kovalev K, Volkov D, Astashkin R, Alekseev A, Gushchin I, Haro-Moreno JM, Chizhov I, Siletsky S, Mamedov M, Rogachev A, Balandin T, Borshchevskiy V, Popov A, Bourenkov G, Bamberg E, Rodriguez-Valera F, Büldt G, Gordeliy V.
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4131-4141.
DOI: 10.1073/pnas.1915888117  |   PUBMED: 32034096  |   IF(2019) = 9.4
PDB [P14]:   

369: Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.
Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C.
Nat Commun. 2020 Jan 23;11(1):440.
DOI: 10.1038/s41467-020-14343-8  |   PUBMED: 31974402  |   IF(2022) = 14.9
PDB [P14]:   

368: Ctf18-RFC and DNA Pol ϵ form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication.
Stokes K, Winczura A, Song B, Piccoli G, Grabarczyk DB.
Nucleic Acids Res. (2020 Aug)48:8128-8145
DOI: 10.1093/nar/gkaa541  |   PUBMED: 32585006  |   IF(2018) = 11.1
PDB [P13]:  6S1C   

367: A Proline-Rich Element in the Type III Secretion Protein FlhB Contributes to Flagellar Biogenesis in the Beta- and Gamma-Proteobacteria.
Hook JC, Blagotinsek V, Pané-Farré J, Mrusek D, Altegoer F, Dornes A, Schwan M, Schier L, Thormann KM, Bange G.
Front Microbiol. (2020 )11:564161
DOI: 10.3389/fmicb.2020.564161  |   PUBMED: 33384667  |   IF(2019) = 4.2
PDB [P13]:  6Z0W   

366: Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P_i Release.
Franz P, Ewert W, Preller M, Tsiavaliaris G.
Int J Mol Sci. (2020 Dec) 22:104
DOI: 10.3390/ijms22010104  |   PUBMED: 33374308  |   IF(2018) = 4.2
PDB [P13]:  7B1A   

365: The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action.
Weikum J, Kulakova A, Tesei G, Yoshimoto S, Jægerum LV, Schütz M, Hori K, Skepö M, Harris P, Leo Morth JP
Sci Rep. 2020 Dec 4;10(1):21249.
DOI: 10.1038/s41598-020-77706-7  |   PUBMED: 33277518  |   IF(2022) = 5.0
PDB [P13P14]:  6TQD  6TPL   

364: HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation.
Songailiene I, Juozapaitis J, Tamulaitiene G, Ruksenaite A, Šulčius S, Sasnauskas G, Venclovas Č, Siksnys V.
Mol Cell. (2020 Dec)80:955-970.e7
DOI: 10.1016/j.molcel.2020.11.034  |   PUBMED: 33290744  |   IF(2018) = 14.5
PDB [P13]:  7AE6  7AE8  7AE9  7AE2   

363: Diamond refractive micro-lenses for full-field X-ray imaging and microscopy produced with ion beam lithography.
Medvedskaya, P., Lyatun, I., Shevyrtalov, S., Polikarpov, M., Snigireva, I., Yunkin, V., & Snigirev, A.
Optics express. 28(4), 4773-S785.
DOI: 10.1364/OE.384647  |   PUBMED: 32121709  |   IF(2019) = 3.67
PDB [P14]:   

362: Crystal structures of a novel family IV esterase in free and substrate-bound form.
Höppner A, Bollinger A, Kobus S, Thies S, Coscolín C, Ferrer M, Jaeger KE, Smits SHJ.
FEBS J. (2020 Dec) UNK:pp. UNK
DOI: 10.1111/febs.15680  |   PUBMED: 33342083  |   IF(2018) = 4.7
PDB [P14]:  6Z68   

361: Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis.
Kozak S, Bloch Y, De Munck S, Mikula A, Bento I, Savvides SN, Meijers R.
Acta Crystallogr D Struct Biol (2020 Dec)76:1244-1255
DOI: 10.1107/s2059798320013753  |   PUBMED: 33263330  |   IF(2018) = 3.2
PDB [P13P14]:  6ZR7  6SFF   

360: Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.
Myllykoski M, Sutinen A, Koski MK, Kallio JP, Raasakka A, Myllyharju J, Wierenga RK, Koivunen P.
J Biol Chem. (2020 Dec)UNK:pp. UNK
DOI: 10.1074/jbc.ra120.016542  |   PUBMED: 33334883  |   IF(2018) = 4.1
PDB [P13]:  6TP5   

359: Inhibition of urease, a Ni-enzyme: the reactivity of a key thiol with mono- and di-substituted catechols elucidated by kinetic, structural and theoretical studies.
Mazzei L, Contaldo U, Musiani F, Cianci M, Bagnolini G, Roberti M, Ciurli S.
Angew Chem Int Ed Engl. (2020 Nov)UNK:pp. UNK
DOI: 10.1002/anie.202014706  |   PUBMED: 33245574  |   IF(2019) = 13.0
PDB [P13]:  6ZNY  6ZNZ  6ZO1   

358: Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
Chaikuad A, Pollinger J, Rühl M, Ni X, Kilu W, Heering J, Merk D.
Int J Mol Sci (2020 Nov)21:pp. UNK
DOI: 10.3390/ijms21228457  |   PUBMED: 33187070
PDB [P13]:  7A77   

357: Structural and functional characterization of the glutathione peroxidase-like thioredoxin peroxidase from the fungus Trichoderma reesei.
Adriani PP, de Paiva FCR, de Oliveira GS, Leite AC, Sanches AS, Lopes AR, Dias MVB, Chambergo FS.
Int J Biol Macromol (2020 Nov)167:93-100
DOI: 10.1016/j.ijbiomac.2020.11.179  |   PUBMED: 33259843  |   IF(2018) = 4.8
PDB [P13]:  6VPD   

356: Phi class glutathione transferases as molecular targets towards multiple-herbicide resistance: Inhibition analysis and pharmacophore design.
Georgakis N, Poudel N, Vlachakis D, Papageorgiou AC, Labrou NE.
Plant Physiol Biochem. (2020 Nov)UNK:pp. UNK
DOI: 10.1016/j.plaphy.2020.11.018  |   PUBMED: 33257232  |   IF(2019) = 3.72
PDB [P14]:  6ZB6   

355: Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B.
J Med Chem. (2020 Nov)63:13709-13718
DOI: 10.1021/acs.jmedchem.0c01202  |   PUBMED: 33143415  |   IF(2018) = 6.1
PDB [P13]:  6ZFM   

354: Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection.
Anjanappa R, Garcia-Alai M, Kopicki JD, Lockhauserbäumer J, Aboelmagd M, Hinrichs J, Nemtanu IM, Uetrecht C, Zacharias M, Springer S, Meijers R.
Nat Commun. (2020 Mar)11:1314
DOI: 10.1038/s41467-020-14862-4  |   PUBMED: 32161266  |   IF(2022) = 14.9
PDB [P14]:  6TDP  6TDO  6TDQ  6TDS  6TDR   

353: Exposing the distinctive modular behavior of β-strands and α-helices in folded proteins.
Wang H, Logan DT, Danielsson J, Oliveberg M.
Proc Natl Acad Sci U S A. (2020 Nov) 117:28775-28783
DOI: 10.1073/pnas.1920455117  |   PUBMED: 33148805  |   IF(2019) = 9.4
PDB [P14]:  6I6E  6I69  6I6I  6I6O   

352: Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter.
Normant V, Josts I, Kuhn L, Perraud Q, Fritsch S, Hammann P, Mislin GLA, Tidow H, Schalk IJ.
ACS Chem Biol. (2020 Oct)15:2741-2751
DOI: 10.1021/acschembio.0c00535  |   PUBMED: 32902248  |   IF(2019) = 4.43
PDB [P14]:  6Z8A   

351: Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode.
Drakou CE, Gardeli C, Tsialtas I, Alexopoulos S, Mallouchos A, Koulas SM, Tsagkarakou AS, Asimakopoulos D, Leonidas DD, Psarra AG, Skamnaki VT.
J Agric Food Chem (2020 Sep)68:10191-10199
DOI: 10.1021/acs.jafc.0c04205  |   PUBMED: 32840370
PDB [P13]:  6YVE   

350: Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Kirsch K, Zeke A, Tőke O, Sok P, Sethi A, Sebő A, Kumar GS, Egri P, Póti ÁL, Gooley P, Peti W, Bento I, Alexa A, Reményi A.
Nat Commun. (2020 Nov)11:5769
DOI: 10.1038/s41467-020-19582-3  |   PUBMED: 33188182  |   IF(2022) = 14.9
PDB [P13P14]:  6ZQS  6ZR5   

349: A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
Stefano JE, Lord DM, Zhou Y, Jaworski J, Hopke J, Travaline T, Zhang N, Wong K, Lennon A, He T, Bric-Furlong E, Cherrie C, Magnay T, Remy E, Brondyk W, Qiu H, Radošević K.
J Biol Chem. (2020 Oct)UNK:pp. UNK
DOI: 10.1074/jbc.ra120.012395  |   PUBMED: 33122192  |   IF(2018) = 4.1
PDB [P14]:  6VC9   

348: Gas channel rerouting in a primordial enzyme: Structural insights of the carbon-monoxide dehydrogenase/acetyl-CoA synthase complex from the acetogen Clostridium autoethanogenum.
Lemaire ON, Wagner T.
Biochim Biophys Acta Bioenerg. (2020 Oct)1862:148330
DOI: 10.1016/j.bbabio.2020.148330  |   PUBMED: 33080205
PDB [P13]:  6YTT   

347: Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.
Liess AKL, Kucerova A, Schweimer K, Schlesinger D, Dybkov O, Urlaub H, Mansfeld J, Lorenz S.
Sci Signal. (2020 Oct)13:pp. UNK
DOI: 10.1126/scisignal.aba8208  |   PUBMED: 33082289  |   IF(2019) = 4.9
PDB [P13]:  6S96   

346: Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System.
Bertelsen MB, Senissar M, Nielsen MH, Bisiak F, Cunha MV, Molinaro AL, Daines DA, Brodersen DE.
Structure. (2020 Oct)UNK:pp. UNK
DOI: 10.1016/j.str.2020.10.002  |   PUBMED: 33096014  |   IF(2022) = 5.0
PDB [P13]:  6ZI0  6ZI1   

345: Structural role of essential light chains in the apicomplexan glideosome.
Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Löw C.
Commun Biol. (2020 Oct)3:568
DOI: 10.1038/s42003-020-01283-8  |   PUBMED: 33051581  |   IF(2019) = 12.1
PDB [P13]:  6ZN3  6TJ4  6TJ5  6TJ6  6TJ7   

344: Structural basis for inhibition of an archaeal CRISPR-Cas type I-D large subunit by an anti-CRISPR protein.
Manav MC, Van LB, Lin J, Fuglsang A, Peng X, Brodersen DE.
Nat Commun. (2020 Nov)11:5993
DOI: 10.1038/s41467-020-19847-x  |   PUBMED: 33239638  |   IF(2022) = 14.9
PDB [P14]:  6THH   

343: Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions.
Michailidou F, Klöcker N, Cornelissen N, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A.
Angew Chem Int Ed Engl. (2020 Oct)UNK:pp. UNK
DOI: 10.1002/anie.202012623  |   PUBMED: 33017502  |   IF(2019) = 13.0
PDB [P13]:  6LTV  6LTW   

342: Rational design of balanced dual-targeting antibiotics with limited resistance.
Nyerges A, Tomaš T, Durcik M, Revesz T, Szili P, Draskovits G, Bogar F, Skok Ž, Zidar N, Ilaš J, Zega A, Kikelj D, Daruka L, Kintses B, Vasarhelyi B, Foldesi I, Kata D, Welin M, Kimbung R, Focht D, Mašič LP, Pal C.
PLoS Biol. 2020 Oct 5;18(10):e3000819.
DOI: 10.1371/journal.pbio.3000819.  |   PUBMED: 33017402  |   IF(2018) = 8.4
PDB [P13]:  6TCK   

341: Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle.
Dudutiene V, Zubriene A, Kairys V, Smirnov A, Smirnovien J, Leitans J, Kazaks A, Tars K, Manakova L, Gražulis S, Matulis D.
Biophys J (2020 Sep)UNK:pp. UNK
DOI: 10.1016/j.bpj.2020.08.037  |   PUBMED: 32971003
PDB [P13P14]:  6T4N  6T4O  6T81  6T5Q  6T5P  6T5C   

340: High-resolution crystal structure and biochemical characterization of a GH11 endoxylanase from Nectria haematococca.
Andaleeb H, Ullah N, Falke S, Perbandt M, Brognaro H, Betzel C.
Sci Rep. (2020 Sep)10:15658
DOI: 10.1038/s41598-020-72644-w  |   PUBMED: 32973265  |   IF(2022) = 5.0
PDB [P13]:  6Y0H   

339: Anomeric Selectivity of Trehalose Transferase with Rare l-Sugars.
Mestrom L, Marsden SR, van der Eijk H, Laustsen JU, Jeffries CM, Svergun DI, Hagedoorn PL, Bento I, Hanefeld U.
ACS Catalysis. (2020 Aug)10:8835-8839
DOI: 10.1021/acscatal.0c02117  |   PUBMED: 32953231  |   IF(2018) = 12.1
PDB [P13]:  6ZJ4  6ZJ7  6ZMZ  6ZJH  6ZN1   

338: Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.
Mokrushina YA, Golovin AV, Smirnov IV, Chatziefthimiou SD, Stepanova AV, Bobik TV, Zalevsky AO, Zlobin AS, Konovalov KA, Terekhov SS, Stepanov AV, Pipiya SO, Shamborant OG, Round E, Belogurov AA, Bourenkov G, Makarov AA, Wilmanns M, Xie J, Blackburn GM, Gabibov AG, Lerner RA.
Proc Natl Acad Sci U S A. (2020 Aug) UNK:pp. UNK
DOI: 10.1073/pnas.2010317117  |   PUBMED: 32859757  |   IF(2019) = 9.4
PDB [P13P14]:  6Y49  6Y1M  6Y1K  6Y1L   

337: Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions.
Stalmans G, Lilina AV, Vermeire PJ, Fiala J, Novák P, Strelkov SV.
Cells. (2020 Jul) 9:pp. UNK
DOI: 10.3390/cells9071633  |   PUBMED: 32645958  |   IF(2019) = 4.4
PDB [-P14]:  6YSH   

336: Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A.
Fiebig T, Cramer JT, Bethe A, Baruch P, Curth U, Führing JI, Buettner FFR, Vogel U, Schubert M, Fedorov R, Mühlenhoff M.
Nat Commun. (2020 Sep)11:4723
DOI: 10.1038/s41467-020-18464-y  |   PUBMED: 32948778  |   IF(2022) = 14.9
PDB [P13P14]:  6YUS  6YUQ   

335: Structural and Functional Characterization of NadR from Lactococcus lactis.
Stetsenko A, Singh R, Jaehme M, Guskov A, Slotboom DJ.
Molecules. (2020 Apr) 25:pp. UNK
DOI: 10.3390/molecules25081940  |   PUBMED: 32331317  |   IF(2020) = 3.3
PDB [P13]:  6GYF  6GZO   

334: Structural and biochemical characterization of a family 7 highly thermostable endoglucanase from the fungus Rasamsonia emersonii.
Schiano-di-Cola C, Kołaczkowski B, Sørensen TH, Christensen SJ, Cavaleiro AM, Windahl MS, Borch K, Morth JP, Westh P.
FEBS J. (2020 Jun) 287:2577-2596
DOI: 10.1111/febs.15151  |   PUBMED: 31755197  |   IF(2018) = 4.7
PDB [P14]:  6SU8   

333: Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S.
J Med Chem. (2020 Jul) 63:6784-6801
DOI: 10.1021/acs.jmedchem.9b01803  |   PUBMED: 32433887  |   IF(2018) = 6.1
PDB [P13]:  6T29   

332: Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis.
Meyer T, Zumbrägel N, Geerds C, Gröger H, Niemann HH.
Biomolecules (2020 Jul) 10:pp. UNK
DOI: OI: 10.3390/biom10081130  |   PUBMED: 32751900
PDB [P13]:  6SMT   

331: The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure.
Engelberg Y, Landau M
Nat Commun. (2020 Aug 4) 11(1):3894.
DOI: 10.1038/s41467-020-17736-x  |   PUBMED: 32753597  |   IF(2022) = 14.9
PDB [P14]:  6S6M   

330: Sjogren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells.
Perdreau-Dahl H, Progida C, Barfeld SJ, Guldsten H, Thiede B, Arntzen M, Bakke O, Mills IG, Krauss S, Morth JP
Commun Biol. (2020 Mar 13) 3(1):123.
DOI: 10.1038/s42003-020-0851-2  |   PUBMED: 32170109  |   IF(2019) = 12.1
PDB [P13]:  6HCZ   

329: Molecular mechanism of light-driven sodium pumping.
Kovalev K, Astashkin R, Gushchin I, Orekhov P, Volkov D, Zinovev E, Marin E, Rulev M, Alekseev A, Royant A, Carpentier P, Vaganova S, Zabelskii D, Baeken C, Sergeev I, Balandin T, Bourenkov G, Carpena X, Boer R, Maliar N, Borshchevskiy V, Buldt G, Bamberg E, Gordeliy V
Nat Commun. (2020 May 1) 11(1):2137.
DOI: 10.1038/s41467-020-16032-y  |   PUBMED: 32358514  |   IF(2022) = 14.9
PDB [P14]:  6YC2  6YC3  6YC4   

328: Structure-based design approach to rational site-directed mutagenesis ofbeta-lactoglobulin.
Bonarek P, Loch JI, Tworzydlo M, Cooper DR, Milto K, Wrobel P, Kurpiewska K, Lewinski K
J Struct Biol. (2020 May 1) 210(2):107493.
DOI: 10.1016/j.jsb.2020.107493  |   PUBMED: 32169624  |   IF(2018) = 3.8
PDB [P13]:  6RYT   

327: Structural Studies of Glutamate Dehydrogenase (Isoform 1) From Arabidopsisthaliana, an Important Enzyme at the Branch-Point Between Carbon and NitrogenMetabolism.
Grzechwiak M, Sliwiak J, Jaskolski M, Ruszkowski M
Front Plant Sci. 2020 Jun 5;11:754.
DOI: 10.3389/fpls.2020.00754  |   PUBMED: 32655590  |   IF(2016) = 4.4
PDB [P13]:  6YEI  6YEH   

326: Architecture and functional dynamics of the pentafunctional AROM complex.
Arora Veraszto H, Logotheti M, Albrecht R, Leitner A, Zhu H, Hartmann MD,
Nat Chem Biol. 2020 Jul 6.
DOI: 10.1038/s41589-020-0587-9  |   PUBMED: 32632294  |   IF(2020) = 41.8
PDB [P14]:  6HQV   

325: Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.
Grabarczyk DB,
Nucleic Acids Res. 2020 Jul 9;48(12):6996-7004.
DOI: 10.1093/nar/gkaa456  |   PUBMED: 32469068  |   IF(2018) = 11.1
PDB [P14]:  6XWX   

324: Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA.
Szewczyk M, Malik D, Borowski LS, Czarnomska SD, Kotrys AV, Klosowska-Kosicka K, Nowotny M, Szczesny RJ,
Nucleic Acids Res. 2020 Jun 4;48(10):5572-5590.
DOI: 10.1093/nar/gkaa302  |   PUBMED: 32365187  |   IF(2018) = 11.1
PDB [P13]:  6STY   

323: Structural basis for antibiotic action of the B1 antivitamin 2'-methoxy-thiamine.
Rabe von Pappenheim F, Aldeghi M, Shome B, Begley T, de Groot BL, Tittmann K.
Nat Chem Biol. (2020 Aug) UNK:pp. UNK
DOI: 10.1038/s41589-020-0628-4  |   PUBMED: 32839604  |   IF(2020) = 41.8
PDB [P14]:  6TJ8  6TJ9   

322: Structural signatures in EPR3 define a unique class of plant carbohydrate receptors.
Wong JEMM, Gysel K, Birkefeldt TG, Vinther M, Muszyński A, Azadi P, Laursen NS, Sullivan JT, Ronson CW, Stougaard J, Andersen KR.
Nat Commun. (2020 Jul)11:3797
DOI: 10.1038/s41467-020-17568-9  |   PUBMED: 32732998  |   IF(2022) = 14.9
PDB [P14]:  6QUP   

321: Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System.
Laursen NS, Pedersen DV, Gytz H, Zarantonello A, Bernth Jensen JM, Hansen AG, Thiel S, Andersen GR.
Front Immunol. (2020 )11:1504
DOI: 10.3389/fimmu.2020.01504  |   PUBMED: 32849513  |   IF(2018) = 6.4
PDB [P14]:  6Z6V   

320: A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Picado A, Chaikuad A, Wells CI, Shrestha S, Zuercher WJ, Pickett JE, Kwarcinski FE, Sinha P, de Silva CS, Zutshi R, Liu S, Kannan N, Knapp S, Drewry DH, Willson TM.
J Med Chem. (2020 Dec)63:14626-14646
DOI: 10.1021/acs.jmedchem.0c01174  |   PUBMED: 33215924  |   IF(2018) = 6.1
PDB [P13]:  6ZJF   

319: An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
Zarantonello A, Presumey J, Simoni L, Yalcin E, Fox R, Hansen A, Olesen HG, Thiel S, Johnson MB, Stevens B, Laursen NS, Carroll MC, Andersen GR.
J Immunol. (2020 Aug)UNK:pp. UNK
DOI: 10.4049/jimmunol.2000528  |   PUBMED: 32769120  |   IF(2019) = 4.7
PDB [P13]:  6YSQ   

318: Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine.
Malik D, Kobyłecki K, Krawczyk P, Poznański J, Jakielaszek A, Napiórkowska A, Dziembowski A, Tomecki R, Nowotny M.
Nucleic Acids Res. (2020 Aug)UNK:pp. UNK
DOI: 10.1093/nar/gkaa647  |   PUBMED: 32785623  |   IF(2018) = 11.1
PDB [P13]:  6YWN  6YWO   

317: Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1.
Shaikhqasem A, Dickmanns A, Neumann P, Ficner R.
J Med Chem. 2020 Jul 7545-7558
DOI: DOI: 10.1021/acs.jmedchem.0c00143  |   PUBMED: 32585100  |   IF(2018) = 6.1
PDB [P14]:  6TVO   

316: MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Sok P, Gógl G, Kumar GS, Alexa A, Singh N, Kirsch K, Sebő A, Drahos L, Gáspári Z, Peti W, Reményi A.
Structure (2020 Jul) pp. UNK
DOI: DOI: 10.1016/j.str.2020.06.007  |   PUBMED: 32649858
PDB [P14]:  6TCA   

315: Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2.
Lindenblatt D, Nickelsen A, Applegate VM, Jose J, Niefind K.
J Med Chem. 2020 Jul7766-7772
DOI: DOI: 10.1021/acs.jmedchem.0c00587  |   PUBMED: 32589844  |   IF(2018) = 6.1
PDB [P13]:  6TEW  6TEI   

314: Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
Mpakali A, Saridakis E, Giastas P, Maben Z, Stern LJ, Larhed M, Hallberg M, Stratikos E.
ACS Med Chem Lett. 2020 Jul1429-1434
DOI: DOI: 10.1021/acsmedchemlett.0c00172  |   PUBMED: 32676150  |   IF(2018) = 3.7
PDB [P13]:  6YDX   

313: Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.
Kupski O, Funk LM, Sautner V, Seifert F, Worbs B, Ramsbeck D, Meyer F, Diederichsen U, Buchholz M, Schilling S, Demuth HU, Tittmann K.
Biochemistry. 2020 Jul2585-2591
DOI: DOI: 10.1021/acs.biochem.0c00337  |   PUBMED: 32551535  |   IF(2018) = 3.0
PDB [P13P14]:  6YI1  6YJY   

312: Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences.
Jolma A, Zhang J, Mondragón E, Morgunova E, Kivioja T, Laverty KU, Yin Y, Zhu F, Bourenkov G, Morris Q, Hughes TR, Maher LJ, Taipale J.
Genome Res. 2020 Julpp. UNK
DOI: DOI: 10.1101/gr.258848.119  |   PUBMED: 32703884  |   IF(2019) = 9.9
PDB [P13]:  6SJD   

311: Heptabladed β-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system.
Fujdiarová E, Houser J, Dobeš P, Paulíková G, Kondakov N, Kononov L, Hyršl P, Wimmerová M.
FEBS J. 2020 J npp. UNK
DOI: DOI: 10.1111/febs.15457  |   PUBMED: 32559333  |   IF(2018) = 4.7
PDB [P13]:  6RGG   

310: A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding.
Terekhov SS, Mokrushina YA, Nazarov AS, Zlobin A, Zalevsky A, Bourenkov G, Golovin A, Belogurov A, Osterman IA, Kulikova AA, Mitkevich VA, Lou HJ, Turk BE, Wilmanns M, Smirnov IV, Altman S, Gabibov AG.
Sci Adv. 2020 6(26):eaaz9861
DOI: 10.1126/sciadv.aaz9861  |   PUBMED: 32637600  |   IF(2018) = 12.5
PDB [P13P14]:  6SUI  6SV5  6SUM  6SUL  6SUN   

309: Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum.
Burda PC, Crosskey T, Lauk K, Zurborg A, Söhnchen C, Liffner B, Wilcke L, Pietsch E, Strauss J, Jeffries CM, Svergun DI, Wilson DW, Wilmanns M, Gilberger TW.
Cell Rep. 2020 Jun107817
DOI: 10.1016/j.celrep.2020.107817  |   PUBMED: 32579913  |   IF(2018) = 8.1
PDB [P13]:  6TLB   

308: Crystal structures of native cytochrome c6 from Thermosynechococcus elongatus in two different space groups and implications for its oligomerization.
Falke S, Feiler C, Chapman H, Sarrou I.
Acta Crystallogr F Struct Biol Commun (2020 Sep)76:444-452
DOI: 10.1107/s2053230x20010249  |   PUBMED: 32880593  |   IF(2019) = 0.97
PDB [P13]:  6TR1   

307: Crystal and solution structures of fragments of the human leucocyte commonantigen-related protein.
Vilstrup J, Simonsen A, Birkefeldt T, Strandbygard D, Lyngso J, Pedersen JS, Thirup S,
Acta Crystallogr D Struct Biol. 2020 May 1;76(Pt 5):406-417.
DOI: 10.1107/S2059798320003885  |   PUBMED: 32355037  |   IF(2018) = 3.2
PDB [P14]:  6TPV   

306: Molecular basis of MKLP2-dependent Aurora B transport from chromatin to theanaphase central spindle.
Serena M, Bastos RN, Elliott PR, Barr FA,
J Cell Biol. 2020 Jul 6;219(7).
DOI: 10.1083/JCB.201910059  |   PUBMED: 32356865  |   IF(2018) = 8.8
PDB [P14]:  6YIE   

305: High-resolution crystal structures of a "half sandwich"-type Ru(II) coordination compound bound to hen egg-white lysozyme and proteinase K.
Chiniadis L, Bratsos I, Bethanis K, Karpusas M, Giastas P, Papakyriakou A,
J Biol Inorg Chem. 2020 Apr 8.
DOI: 10.1007/S00775-020-01786-Z  |   PUBMED: 32266561  |   IF(2018) = 3.6
PDB [P13]:  6TXG   

304: Crossing the Border: From Keto- to Imine Reduction in Short-ChainDehydrogenases/Reductases.
Muller M, Roth S, Stockinger P, Steff J, Steimle S, Sautner V, Tittmann K, Pleiss J,
ChemBioChem. 2020 Apr 21.
DOI: 10.1002/CBIC.202000233  |   PUBMED: 32315494  |   IF(2018) = 2.6
PDB [P14]:  6Y4D   

303: Structural and functional characterization of the severe fever withthrombocytopenia syndrome virus L protein.
Vogel D, Thorkelsson SR, Quemin ERJ, Meier K, Kouba T, Gogrefe N, Busch C, Reindl S, Gunther S, Cusack S, Grunewald K, Rosenthal M
Nucleic Acids Res. 2020 Jun 4;48(10):5749-5765.
DOI: 10.1093/nar/gkaa253  |   PUBMED: 32313945  |   IF(2018) = 11.1
PDB [P14]:  6XYA   

302: Flexible loops of New Delhi metallo-beta-lactamase modulate its activity towards different substrates.
Raczynska JE, Imiolczyk B, Komorowska M, Sliwiak J, Czyrko-Horczak J, Brzezinski K, Jaskolski M,
Int J Biol Macromol. 2020 Apr 28;158:104-115.
DOI: 10.1016/J.IJBIOMAC.2020.04.219  |   PUBMED: 32353499  |   IF(2018) = 4.8
PDB [P13]:  6TWT   

301: Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding:Hint on Differences in Selectivity Determinants of Both Proteins?
Ngo K, Collins-Kautz C, Gerstenecker S, Wagner B, Heine A, Klebe G,
J Med Chem. 2020 Mar 26;63(6):3274-3289.
DOI: 10.1021/ACS.JMEDCHEM.9B02061  |   PUBMED: 32011145  |   IF(2018) = 6.1
PDB [P13]:  6T0M  6T0P   

300: Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Singh K, Graf B, Linden A, Sautner V, Urlaub H, Tittmann K, Stark H, Chari A
Cell. 2020 Mar 19;180(6):1130-1143.e20.
DOI: 10.1016/j.cell.2020.02.034  |   PUBMED: 32160528  |   IF(2018) = 36.2
PDB [P14]:  6QL9  6QL7   

299: A Proof-of-Concept Fragment Screening of a Hit-Validated 96-Compounds Libraryagainst Human Carbonic Anhydrase II.
Glockner S, Heine A, Klebe G
Biomolecules. 2020 Mar 29;10(4).
DOI: 10.3390/BIOM10040518  |   PUBMED: 32235320  |   IF(2019) = 4.7
PDB [P13P14]:  6S9Z  6RMP  5M78   

298: Halogenated and di-substituted benzenesulfonamides as selective inhibitors ofcarbonic anhydrase isoforms.
Zaksauskas A, Capkauskaite E, Jezepcikas L, Linkuviene V, Paketuryte V, Smirnov A, Leitans J, Kazaks A, Dvinskis E, Manakova E, Grazulis S, Tars K, Matulis D,
Eur J Med Chem. 2020 Jan 1;185:111825.
DOI: 10.1016/J.EJMECH.2019.111825  |   PUBMED: 31740053  |   IF(2018) = 4.8
PDB [P14]:  6R6Y   

297: Regioselectivity of hyoscyamine 6β-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations.
Kluza A, Wojdyla Z, Mrugala B, Kurpiewska K, Porebski PJ, Niedzialkowska E, Minor W, Weiss MS, Borowski T.
Dalton T. ( 2020 Apr ) 49 :4454-4469
DOI: 10.1039/d0dt00302f  |   PUBMED: 32182320  |   IF(2018) = 4.1
PDB [P13]:  6TTM   

296: Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture.
Gulen B, Rosselin M, Fauser J, Albers MF, Pett C, Krisp C, Pogenberg V, Schlüter H, Hedberg C, Itzen A.
Nat Chem. (2020 Aug)12:732-739
DOI: 10.1038/s41557-020-0484-6  |   PUBMED: 32632184  |   IF(2019) = 21.7
PDB [P13]:  6SIU   

295: Loss of GFAT-1 feedback regulation activates the hexosamine pathway thatmodulates protein homeostasis.
Ruegenberg S, Horn M, Pichlo C, Allmeroth K, Baumann U, Denzel MS,
Nat Commun. 2020 Feb 4;11(1):687.
DOI: 10.1038/s41467-020-14524-5  |   PUBMED: 32019926  |   IF(2022) = 14.9
PDB [P13]:  6SVO   

294: Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2.
Hamann F, Schmitt A, Favretto F, Hofele R, Neumann P, Xiang S, Urlaub H, Zweckstetter M, Ficner R,
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2948-2956.
DOI: 10.1073/pnas.1907960117  |   PUBMED: 31974312  |   IF(2019) = 9.4
PDB [P13P14]:  6R4E  6RM8  6RMC  6RMB  6RMA  6RM9   

293: p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Gebel J, Tuppi M, Chaikuad A, Hotte K, Schroder M, Schulz L, Lohr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dotsch V,
Nat Chem Biol. 2020 Jul 27. pii: 10.1038/s41589-020-0600-3. doi:10.1038/s41589-020-0600-3.
DOI: 10.1038/s41589-020-0600-3 [doi]  |   PUBMED: 32719556  |   IF(2020) = 41.8
PDB [P13]:  6RU6   

292: Structure of a robust bacterial protein cage and its application as a versatile biocatalytic platform through enzyme encapsulation.
Lončar N, Rozeboom HJ, Franken LE, Stuart MCA, Fraaije MW.
Biochem Biophys Res Commun. (2020 Aug)529:548-553
DOI: 10.1016/j.bbrc.2020.06.059  |   PUBMED: 32736672  |   IF(2019) = 3.0
PDB [P13]:  6I9G   

291: A Novel Polyester Hydrolase From the Marine Bacterium Pseudomonas aestusnigri - Structural and Functional Insights.
Bollinger A, Thies S, Knieps-Grünhagen E, Gertzen C, Kobus S, Höppner A, Ferrer M, Gohlke H, Smits SHJ, Jaeger .
Front Microbiol. (2020 )11:114
DOI: 10.3389/fmicb.2020.00114  |   PUBMED: 32117139  |   IF(2019) = 4.2
PDB [P13]:  6SCD   

290: The structural basis of fungal glucuronoyl esterase activity on natural substrates.
Ernst HA, Mosbech C, Langkilde AE, Westh P, Meyer AS, Agger JW, Larsen S
Nat Commun. 2020 Feb 24;11(1):1026.
DOI: 10.1038/S41467-020-14833-9  |   PUBMED: 32094331  |   IF(2022) = 14.9
PDB [P13]:  6RU1   

289: Triple-Helix-Stabilizing Effects in Collagen Model Peptides ContainingPPII-Helix-Preorganized Diproline Modules.
Maassen A, Gebauer JM, Theres Abraham E, Grimm I, Neudorfl JM, Kuhne R, Neundorf I, Baumann U, Schmalz HG,
ngew Chem Int Ed Engl. 2020 Jan 16.
DOI: 10.1002/ANIE.201914101  |   PUBMED: 31944532
PDB [P13]:  6SYJ   

288: Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
Lillebostad PAG, Raasakka A, Hjellbrekke SJ, Patil S, Røstbø T, Hollås H, Sakya SA, Szigetvari PD, Vedeler A, Kursula P.
Biomolecules (2020 Apr)10:pp. UNK
DOI: 10.3390/biom10040660  |   PUBMED: 32344647
PDB [P13]:  6TU2   

Number of publications for 2020: 95

2019

287: The Impact of pH on Catalytically Critical Protein Conformational Changes: The Case of the Urease, a Nickel Enzyme.
Mazzei L, Cianci M, Benini S, Ciurli S
Chemistry. 2019 Sep 18;25(52):12145-12158.
DOI: 10.1002/CHEM.201902320  |   PUBMED: 31271481  |   IF(2019) = 4.9
PDB [P13]:  6RP1  6RKG   

286: Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties.
Gagner VA, Lundholm I, Garcia-Bonete MJ, Rodilla H, Friedman R, Zhaunerchyk V, Bourenkov G, Schneider T, Stake J, Katona G,
Sci Rep. 2019 Dec 17;9(1):19281.
DOI: 10.1038/s41598-019-55777-5  |   PUBMED: 31848402  |   IF(2022) = 5.0
PDB [P14]:  6SW0  6SVG  6SVZ  6SVU  6SVW  6RIV  6SVX  6SVD  6SUX  6SVV  6SV9  6SV8  6SVB  6SV0  6SV6  6SVJ  6SVI  6SVN  6SVR   

285: Identification and characterization of a novel chemotype for human TLR8 inhibitors.
Sribar D, Grabowski M, Murgueitio MS, Bermudez M, Weindl G, Wolber G,
Eur J Med Chem. 2019 Oct 1;179:744-752. Epub2019 Jun 29.
DOI: 10.1016/J.EJMECH.2019.06.084  |   PUBMED: 31284084  |   IF(2018) = 4.8
PDB [P14]:  6R6F   

284: Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.
De Bortoli F, Neumann A, Kotte A, Timmermann B, Schuler T, Wahl MC, Loll B, Heyd F,
Nucleic Acids Res. 2019 Jun 20;47(11):5867-5879.
DOI: 10.1093/nar/gkz243  |   PUBMED: 30949712  |   IF(2018) = 11.1
PDB [P14]:   

283: Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses.
Alvarez CE, Bovdilova A, Hoppner A, Wolff CC, Saigo M, Trajtenberg F, Zhang T, Buschiazzo A, Nagel-Steger L, Drincovich MF, Lercher MJ, Maurino VG,
Nat Plants. 2019 Jul;5(7):755-765. Epub 2019 Jun 24.
DOI: 10.1038/s41477-019-0451-7  |   PUBMED: 31235877  |   IF(2019) = 13.3
PDB [P13]:   

282: Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target.
Schussler S, Haase I, Perbandt M, Illarionov B, Siemens A, Richter K, Bacher A, Fischer M, Grawert T,
Acta Crystallogr F Struct Biol Commun. 2019 Sep 1;75(Pt 9):586-592. Epub 2019 Aug 30.
DOI: 10.1107/S2053230X19010902  |   PUBMED: 31475925  |   IF(2019) = 0.97
PDB [P14]:  4UQF   

281: Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.
Giastas P, Mpakali A, Papakyriakou A, Lelis A, Kokkala P, Neu M, Rowland P, Liddle J, Georgiadis D, Stratikos
Proc Natl Acad Sci U S A. 2019 Dec
DOI: 10.1073/pnas.1912070116  |   PUBMED: 31843903  |   IF(2019) = 9.4
PDB [P13]:  6RYF  6RQX   

280: Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype.
Driller R, Ballaschk M, Schmieder P, Uchanska-Ziegler B, Ziegler A, Loll B,
J Biol Chem. 2019 Sep 6;294(36):13269-13279. Epub 2019 Jul 11.
DOI: 10.1074/jbc.RA119.008937  |   PUBMED: 31296658  |   IF(2018) = 4.1
PDB [P14]:  5IB3   

279: Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.
Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U
Cell. 2019 Dec 12;179(7):1537-1550.e19.
DOI: 10.1016/j.cell.2019.11.024  |   PUBMED: 31835032  |   IF(2018) = 36.2
PDB [P13]:  6RFG   

278: Visualization of protein crystals by high-energy phase-contrast X-ray imaging.
Polikarpov M, Bourenkov G, Snigireva I, Snigirev A, Zimmermann S, Csanko K, Brockhauser S, Schneider TR,
Acta Crystallogr D Struct Biol. 2019 Nov 1;75(Pt 11):947-958. Epub 2019 Oct 31.
DOI: 10.1107/S2059798319011379  |   PUBMED: 31692469  |   IF(2018) = 3.2
PDB [P14]:   

277: Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.
de Mare SW, Venskutonyte R, Eltschkner S, de Groot BL, Lindkvist-Petersson K,
Structure. 2019 Nov 29.
DOI: 10.1016/j.str.2019.11.011  |   PUBMED: 31831212  |   IF(2022) = 5.0
PDB [P13]:  6QZJ  6QZI   

276: The Structure of the Elusive Urease-Urea Complex Unveils the Mechanism of a Paradigmatic Nickel-Dependent Enzyme.
Mazzei L, Cianci M, Benini S, Ciurli S,
Angew Chem Int Ed Engl. 2019 May 27;58(22):7415-7419. Epub 2019 Apr 30.
DOI: 10.1002/ANIE.201903565  |   PUBMED: 30969470  |   IF(2019) = 13.0
PDB [P13]:  6QDY   

275: Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold.
Sykorova P, Novotna J, Demo G, Pompidor G, Dubska E, Komarek J, Fujdiarova E, Houser J, Haronikova L, Varrot A, Shilova N, Imberty A, Bovin N, Pokorna M, Wimmerova M,
Int J Biol Macromol. 2019 Nov 18.
DOI: 10.1016/J.IJBIOMAC.2019.10.200  |   PUBMED: 31751748  |   IF(2018) = 4.8
PDB [P13]:  6GXR  6GXS   

274: Molecular insight into a new low-affinity xylan binding module from thexylanolytic gut symbiont Roseburia intestinalis.
Leth ML, Ejby M, Madland E, Kitaoku Y, Slotboom DJ, Guskov A, Aachmann FL, Abou Hachem M,
FEBS J. 2019 Nov 6.
DOI: 10.1111/FEBS.15117  |   PUBMED: 31693302  |   IF(2018) = 4.7
PDB [P13]:  6SGF   

273: Unique structure and function of viral rhodopsins.
Bratanov D, Kovalev K, Machtens JP, Astashkin R, Chizhov I, Soloviov D, Volkov D, Polovinkin V, Zabelskii D, Mager T, Gushchin I, Rokitskaya T, Antonenko Y, Alekseev A, Shevchenko V, Yutin N, Rosselli R, Baeken C, Borshchevskiy V, Bourenkov G, Popov A, Balandin T, Buldt G, Manstein DJ, Rodriguez-Valera F, Fahlke C, Bamberg E, Koonin E, Gordeliy V,
Nat Commun. 2019 Oct 30;10(1):4939.
DOI: 10.1038/S41467-019-12718-0  |   PUBMED: 31666521  |   IF(2022) = 14.9
PDB [P14]:  6SQG  6XYT   

272: Optical performance and radiation stability of polymer X-ray refractive nano-lenses.
Barannikov A, Polikarpov M, Ershov P, Bessonov V, Abrashitova K, Snigireva I, Yunkin V, Bourenkov G, Schneider T, Fedyanin AA, Snigirev A,
J Synchrotron Rad. 2019 May 1;26(Pt 3):714-719. Epub 2019 Apr 1.
DOI: 10.1107/S1600577519001656  |   PUBMED:   |   IF(2018) = 2.5
PDB [P14]:   

271: Molecular features of the UNC-45 chaperone critical for binding and foldingmuscle myosin.
Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T
Nat Commun. 2019 Oct 21;10(1):4781.
DOI: 10.1038/S41467-019-12667-8  |   PUBMED: 31636255  |   IF(2022) = 14.9
PDB [P13]:  6QDJ   

270: CRL-based ultra-compact transfocator for X-ray focusing and microscopy.
Narikovich A, Polikarpov M, Barannikov A, Klimova N, Lushnikov A, Lyatun I, Bourenkov G, Zverev D, Panormov I, Sinitsyn A, Snigireva I, Snigirev A,
J Synchrotron Rad. 2019 Jul 1;26(Pt 4):1208-1212. Epub 2019 Jun 18.
DOI: 10.1107/S1600577519005708  |   PUBMED:   |   IF(2018) = 2.5
PDB [P14]:   

269: Crystal structure of the EcoKMcrA N-terminal domain (NEco): recognition of modified cytosine bases without flipping.
Slyvka A, Zagorskaite E, Czapinska H, Sasnauskas G, Bochtler M,
Nucleic Acids Res. 2019 Nov 14.
DOI: 10.1093/nar/gkz1017  |   PUBMED: 31724709   |   IF(2018) = 11.1
PDB [P14]:  6T22  6T21   

268: Metal binding to the dynamic cytoplasmic domain of the cation diffusionfacilitator (CDF) protein MamM induces a 'locked-in' configuration.
Barber-Zucker S, Hall J, Mangapuram SV, Kass I, Kolusheva S, MacMillan F, Zarivach R, Henn A,
FEBS J. 2019 Jun;286(11):2193-2215. Epub 2019 Mar 20.
DOI: 10.1111/febs.14795  |   PUBMED: 30811856  |   IF(2018) = 4.7
PDB [P13]:  6G55   

267: UNEXPECTED ENZYME-CATALYSED [4+2] CYCLOADDITION AND REARRANGEMENT IN POLYETHER ANTIBIOTIC BIOSYNTHESIS
R.LITTLE,F.C.R.PAIVA,R.JENKINS,H.HONG,Y.SUN,Y.DEMYDCHUK, M.SAMBORSKYY,M.TOSIN,F.J.LEEPER,M.V.B.DIAS,P.F.LEADLAY
Nat Catal. 2019 2:1045-1054
DOI: 10.1038/S41929-019-0351-2  |   PUBMED: NONE  |   IF(2021) = 47.2
PDB [P13]:  6NNW   

266: The Crystal Structure of the Plasmodium falciparum PdxK Provides an Experimental Model for Pro-Drug Activation
Gao K, Wang W, Kronenberger T, Wrenger C, Groves MR
Crystals. 2019 9(10): 534
DOI: 10.3390/CRYST9100534  |   PUBMED:   |   IF(2018) = 2.4
PDB [P13]:  6SU9   

265: Liquid application method for time-resolved analyses by serial synchrotron crystallography.
Mehrabi P, Schulz EC, Agthe M, Horrell S, Bourenkov G, von Stetten D, Leimkohl JP, Schikora H, Schneider TR, Pearson AR, Tellkamp F, Miller RJD
Nat Methods. 2019 Oct;16(10):979-982. Epub 2019Sep 16.
DOI: 10.1038/S41592-019-0553-1  |   PUBMED: 31527838  |   IF(2018) = 28.5
PDB [P14]:  6RNC  6RNB  6RND  6RNF  6QNJ  6QNH  6QNI  6QND  6QNB  6QNC   

264: Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
Voss M, Toelzer C, Bhandari DD, Parker JE, Niefind K
J Struct Biol. 2019 Sep 21.
DOI: 10.1016/J.JSB.2019.09.007  |   PUBMED: 31550533  |   IF(2018) = 3.8
PDB [P13]:  6I8H   

263: Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal are negatively coupled.
Moritzer AC, Niemann HH
Protein Sci. 2019 Oct 7.
DOI: 10.1002/PRO.3739  |   PUBMED: 31589794  |   IF(2018) = 2.4
PDB [P13]:  6SLT  6SLS   

262: Sub-Atomic Resolution Crystal Structures Reveal Conserved Geometric Outliers atFunctional Sites.
Laulumaa S, Kursula P,
Molecules. 2019 Aug 22;24(17).
DOI: 10.3390/molecules24173044.  |   PUBMED: 31443388  |   IF(2020) = 3.3
PDB [P13]:  6S2S   

261: Marine Proteobacteria metabolize glycolate via the beta-hydroxyaspartate cycle.
Schada von Borzyskowski L, Severi F, Kruger K, Hermann L, Gilardet A, Sippel F, Pommerenke B, Claus P, Cortina NS, Glatter T, Zauner S, Zarzycki J, Fuchs BM, Bremer E, Maier UG, Amann RI, Erb TJ,
Nature. 2019 Nov;575(7783):500-504. Epub 2019 Nov13.
DOI: 10.1038/s41586-019-1748-4  |   PUBMED: 31723261  |   IF(2018) = 43.1
PDB [P13]:  6RQA   

260: High-throughput peptide-MHC complex generation and kinetic screenings of TCRswith peptide-receptive HLA-A*02:01 molecules.
Moritz A, Anjanappa R, Wagner C, Bunk S, Hofmann M, Pszolla G, Saikia A, Garcia-Alai M, Meijers R, Rammensee HG, Springer S, Maurer D,
Sci Immunol. 2019 Jul 19;4(37).
DOI: 10.1126/sciimmunol.aav0860  |   PUBMED: 31324691  |   IF(2018) = 10.5
PDB [P13P14]:  6Q3K  6Q3S   

259: Structural insights into synthetic ligands targeting A-A pairs in disease-relatedCAG RNA repeats.
Mukherjee S, Blaszczyk L, Rypniewski W, Falschlunger C, Micura R, Murata A, Dohno C, Nakatani K, Kiliszek A,
Nucleic Acids Res. 2019 Nov 18;47(20):10906-10913.
DOI: 10.1093/nar/gkz832  |   PUBMED: 31566242  |   IF(2018) = 11.1
PDB [P13]:  6QIQ   

258: Active Site Architecture and Reaction Mechanism Determination of Cold Adapted beta-d-galactosidase from Arthrobacter sp. 32cB.
Rutkiewicz M, Bujacz A, Wanarska M, Wierzbicka-Wos A, Cieslinski H
Int J Mol Sci. 2019 Sep 3;20(17).
DOI: 10.3390/ijms20174301  |   PUBMED: 31484304  |   IF(2018) = 4.2
PDB [P13]:  6SE8   

257: Low-barrier hydrogen bonds in enzyme cooperativity.
Dai S, Funk LM, von Pappenheim FR, Sautner V, Paulikat M, Schroder B, Uranga J, Mata RA, Tittmann K,
Nature. 2019 Sep 18.
DOI: 10.1038/s41586-019-1581-9  |   PUBMED: 31534226  |   IF(2018) = 43.1
PDB [P13P14]:  6HAD  6HA3  6RJB  6RJC  6HAF   

256: Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Pedersen DV, Gadeberg TAF, Thomas C, Wang Y, Joram N, Jensen RK, Mazarakis SMM, Revel M, El Sissy C, Petersen SV, Lindorff-Larsen K, Thiel S, Laursen NS, Fremeaux-Bacchi V, Andersen GR,
Front Immunol. 2019 Aug 22;10:2007. eCollection2019.
DOI: 10.3389/fimmu.2019.02007  |   PUBMED: 31507604  |   IF(2018) = 6.4
PDB [P13P14]:  6SEJ  6RV6  6RUV  6RUR  6RU5  6RU3   

255: Time-resolved crystallography reveals allosteric communication aligned withmolecular breathing.
Mehrabi P, Schulz EC, Dsouza R, Muller-Werkmeister HM, Tellkamp F, Miller RJD, Pai EF,
Science. 2019 Sep 13;365(6458):1167-1170.
DOI: 10.1126/SCIENCE.AAW9904  |   PUBMED: 31515393  |   IF(2018) = 41.1
PDB [P14]:  6QI1  6QHY  6QHX   

254: The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNABinding Domain.
Manav MC, Turnbull KJ, Jurenas D, Garcia-Pino A, Gerdes K, Brodersen DE,
Structure. 2019 Sep 4.
DOI: 10.1016/J.STR.2019.08.008  |   PUBMED: 31495532  |   IF(2022) = 5.0
PDB [P13P14]:  6HPB  6HPC   

253: Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure andAffinities of Inhibitors.
Kazokaite J, Kairys V, Smirnoviene J, Smirnov A, Manakova E, Tolvanen M, Parkkila S, Matulis D,
Sci Rep. 2019 Sep 3;9(1):12710.
DOI: 10.1038/S41598-019-49094-0  |   PUBMED: 31481705  |   IF(2022) = 5.0
PDB [P14]:  6QL3  6QL2  6QL1   

252: Ternary structure of the outer membrane transporter FoxA with resolved signallingdomain provides insights into TonB-mediated siderophore uptake.
Josts I, Veith K, Tidow H
Elife. 2019 Aug 6;8.
DOI: 10.7554/ELIFE.48528  |   PUBMED: 31385808  |   IF(2018) = 7.6
PDB [P13]:  6I98  6I97   

251: Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S byAutoubiquitination.
Liess AKL, Kucerova A, Schweimer K, Yu L, Roumeliotis TI, Diebold M, Dybkov O, Sotriffer C, Urlaub H, Choudhary JS, Mansfeld J, Lorenz S
Structure. 2019 Jun 4.
DOI: 10.1016/J.STR.2019.05.008  |   PUBMED: 31230944  |   IF(2022) = 5.0
PDB [P14]:  6QH3   

250: Class Id ribonucleotide reductase utilizes a Mn2(IV,III) cofactor and undergoes large conformational changes on metal loading.
Rozman Grinberg I, Berglund S, Hasan M, Lundin D, Ho FM, Magnuson A, Logan DT, Sjoberg BM, Berggren G
J Biol Inorg Chem. 2019 Aug 14.
DOI: 10.1007/S00775-019-01697-8  |   PUBMED: 31414238  |   IF(2018) = 3.6
PDB [P13P14]:  6SF5  6SF4   

249: Atomic view into Plasmodium actin polymerization, ATP hydrolysis, andfragmentation.
Kumpula EP, Lopez AJ, Tajedin L, Han H, Kursula I
PLoS Biol. 2019 Jun 14;17(6):e3000315.
DOI: 10.1371/JOURNAL.PBIO.3000315  |   PUBMED: 31199804  |   IF(2018) = 8.4
PDB [P13]:  6I4M  6I4D  6I4E   

248: Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1.
Pichlo C, Juetten L, Wojtalla F, Schacherl M, Diaz D, Baumann U,
J Biol Chem. 2019 Jun 10.
DOI: 10.1074/jbc.RA119.009029  |   PUBMED: 31182482  |   IF(2018) = 4.1
PDB [P13]:  6R59  6R4X   

247: NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly highligand release efficacy.
Gardill BR, Schmidt K, Muller YA,
J Struct Biol. 2019 May 16.
DOI: 10.1016/J.JSB.2019.05.006  |   PUBMED: 31103428  |   IF(2018) = 3.8
PDB [P13]:  6HGG  6HGJ  6HGI  6HGK   

246: Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
Andres F, Iamele L, Meyer T, Stuber JC, Kast F, Gherardi E, Niemann HH, Pluckthun A,
J Mol Biol. 2019 May 3;431(10):2020-2039. Epub2019 Mar 28.
DOI: 10.1016/J.JMB.2019.03.024  |   PUBMED: 30930049  |   IF(2018) = 5.1
PDB [P13]:  6GCU   

245: Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to asubstrate.
Palm GJ, Reisky L, Bottcher D, Muller H, Michels EAP, Walczak MC, Berndt L, Weiss MS, Bornscheuer UT, Weber G,
Nat Commun. 2019 Apr 12;10(1):1717.
DOI: 10.1038/S41467-019-09326-3  |   PUBMED: 30979881  |   IF(2022) = 14.9
PDB [P13]:  6QGC   

244: Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in theBiosynthesis of Gentamicin.
de Araujo NC, Bury PDS, Tavares MT, Huang F, Parise-Filho R, Leadlay P, Dias MVB,
ACS Chem Biol. 2019 May 17;14(5):925-933. Epub2019 Apr 30.
DOI: 10.1021/ACSCHEMBIO.9B00115  |   PUBMED: 30995396  |   IF(2019) = 4.43
PDB [P13]:  6NOR   

243: A surface-exposed GH26 beta-mannanase from Bacteroides ovatus: Structure, role, and phylogenetic analysis of BoMan26B.
Bagenholm V, Wiemann M, Reddy SK, Bhattacharya A, Rosengren A, Logan DT, Stalbrand H,
J Biol Chem. 2019 Jun 7;294(23):9100-9117. Epub2019 Apr 18.
DOI: 10.1074/jbc.RA118.007171  |   PUBMED: 31000630  |   IF(2018) = 4.1
PDB [P13]:  6HF2   

242: Structural Insights into Curli CsgA Cross-beta Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents.
Perov S, Lidor O, Salinas N, Golan N, Tayeb-Fligelman E, Deshmukh M, Willbold D, Landau M
PLoS Pathog. 2019 Aug 30;15(8):e1007978. eCollection 2019 Aug.
DOI: 10.1371/journal.ppat.1007978  |   PUBMED: 31469892  |   IF(2018) = 6.1
PDB [P14]:  6G8C  6G8D  6G9G   

241: CH-PI INTERACTIONS PROMOTE THE CONVERSION OF HYDROXYPYRUVATE IN A CLASS II PYRUVATE ALDOLASE
S.R.MARSDEN,L.MESTROM,I.BENTO,P.L.HAGEDOORN,D.G.G.MCMILLAN, U.HANEFELD
Adv Synth Catal. 2019 , 361
DOI: 10.1002/ADSC.201900205  |   PUBMED:   |   IF(2018) = 5.5
PDB [P13]:  6R62   

240: (p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch.
Zhang YE, Baerentsen RL, Fuhrer T, Sauer U, Gerdes K, Brodersen DE,
Mol Cell. 2019 Apr 16.
DOI: 10.1016/J.MOLCEL.2019.03.035  |   PUBMED: 31023582  |   IF(2018) = 14.5
PDB [P13]:  6GFM   

239: Crystal structures of the c-di-AMP synthesizing enzyme CdaA.
Heidemann JL, Neumann P, Dickmanns A, Ficner R,
J Biol Chem. 2019 May 22.
DOI: 10.1074/JBC.RA119.009246  |   PUBMED: 31118276  |   IF(2018) = 4.1
PDB [P13P14]:  6HVM  6HVN  6HVL   

238: Structure of a functional cap-binding domain in Rift Valley fever virus Lprotein.
Gogrefe N, Reindl S, Gunther S, Rosenthal M,
PLoS Pathog. 2019 May 28;15(5):e1007829.
DOI: 10.1371/JOURNAL.PPAT.1007829  |   PUBMED: 31136637  |   IF(2018) = 6.1
PDB [P13]:  6QHG   

237: Protein crystallization promotes type 2 immunity and is reversible by antibodytreatment.
Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Goncalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN,
Science. 2019 May 24;364(6442).
DOI: 10.1126/SCIENCE.AAW4295  |   PUBMED: 31123109  |   IF(2018) = 41.1
PDB [P14]:  6QRN  6GKS  6GKQ   

236: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebscycle.
Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K,
Nature. 2019 Apr 3.
DOI: 10.1038/S41586-019-1095-5  |   PUBMED: 30944476  |   IF(2018) = 43.1
PDB [P13P14]:  6HXK  6QCL  6QFB   

235: Structural Comparison of Enterococcus faecalis and Human Thymidylate SynthaseComplexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints aboutEnzyme Conformational Variabilities.
Pozzi C, Ferrari S, Luciani R, Tassone G, Costi MP, Mangani S,
Molecules. 2019 Mar 31;24(7).
DOI: 10.3390/MOLECULES24071257  |   PUBMED: 30935102  |   IF(2020) = 3.3
PDB [P14]:  6QXH   

234: Structural basis for RNA translocation by DEAH-box ATPases.
Hamann F, Enders M, Ficner R,
Nucleic Acids Res. 2019 Mar 4.
DOI: 10.1093/NAR/GKZ150  |   PUBMED: 30828714  |   IF(2018) = 11.1
PDB [P13]:  6I3O  6QIE  6QIC  6I3P   

233: Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by aReliable Path to Atomic Resolution CK2alpha' Structures.
Lindenblatt D, Nickelsen A, Applegate VM, Hochscherf J, Witulski B, Bouaziz Z, Marminon C, Bretner M, Le Borgne M, Jose J, Niefind K,
ACS Omega. 2019 Mar 19;4(3):5471-5478. eCollection2019 Mar 31.
DOI: 10.1021/acsomega.8b03415  |   PUBMED: 31559376  |   IF(2018) = 2.6
PDB [P13]:  6HME   

232: High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor.
Giastas P, Neu M, Rowland P, Stratikos E,
ACS Med Chem Lett. 2019 Feb 13;10(5):708-713. eCollection 2019 May 9.
DOI: 10.1021/ACSMEDCHEMLETT.9B00002  |   PUBMED: 31097987  |   IF(2018) = 3.7
PDB [P13]:  6Q4R   

231: An NAD(+) Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.
Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Svergun DI, Schnappinger D, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O,
Mol Cell. 2019 Mar 21;73(6):1282-1291.e8. Epub2019 Feb 18.
DOI: 10.1016/j.molcel.2019.01.028  |   PUBMED: 30792174  |   IF(2018) = 14.5
PDB [P13]:  6FKG   

230: Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 InhibitorsModified with Chiral Pyrrolidine Scaffolds.
Luxenburger A, Schmidt D, Ianes C, Pichlo C, Kruger M, von Drathen T, Brunstein E, Gainsford GJ, Baumann U, Knippschild U, Peifer C,
Molecules. 2019 Mar 1;24(5).
DOI: 10.3390/MOLECULES24050873  |   PUBMED: 30832206  |   IF(2020) = 3.3
PDB [P13]:  6F1W   

229: Active site complementation and hexameric arrangement in the GH family 29; astructure-function study of alpha-l-fucosidase isoenzyme 1 from Paenibacillusthiaminolyticus.
Kovalova T, Koval T, Benesova E, Vodickova P, Spiwok V, Lipovova P, Dohnalek J,
Glycobiology. 2019 Jan 1;29(1):59-73.
DOI: 10.1093/GLYCOB/CWY078  |   PUBMED: 30544181  |   IF(2018) = 4.2
PDB [P13]:  6GN6   

228: Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
Cruz-Migoni A, Canning P, Quevedo CE, Bataille CJR, Bery N, Miller A, Russell AJ, Phillips SEV, Carr SB, Rabbitts TH,
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2545-2550. Epub 2019 Jan 25.
DOI: 10.1073/PNAS.1811360116  |   PUBMED: 30683716  |   IF(2019) = 9.4
PDB [P14]:  6GQW  6GQY  6GQX   

227: Long-wavelength Mesh&Collect native SAD phasing from microcrystals.
Cianci M, Nanao M, Schneider TR,
Acta Crystallogr D Struct Biol. 2019 Feb 1;75(Pt 2):192-199. Epub 2019 Feb 11.
DOI: 10.1107/S2059798319002031  |   PUBMED: 30821707  |   IF(2018) = 3.2
PDB [P13]:  6H2M   

226: Structural and computational basis for potent inhibition of glutamatecarboxypeptidase II by carbamate-based inhibitors.
Barinka C, Novakova Z, Hin N, Bim D, Ferraris DV, Duvall B, Kabarriti G, Tsukamoto R, Budesinsky M, Motlova L, Rojas C, Slusher BS, Rokob TA, Rulisek L, Tsukamoto T.
Bioorg Med Chem. 2019 Jan 15;27(2):255-264. Epub 2018 Nov 14.
DOI: 10.1016/j.bmc.2018.11.022  |   PUBMED: 30552009  |   IF(2018) = 2.5
PDB [P13]:  6EZ9  6FE5  6ETY  6F5L   

225: Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.
Ural-Blimke Y, Flayhan A, Strauss J, Rantos V, Bartels K, Nielsen R, Pardon E, Steyaert J, Kosinski J, Quistgaard EM, Low C,
J Am Chem Soc. 2019 Jan 31.
DOI: 10.1021/JACS.8B11343  |   PUBMED: 30644743  |   IF(2018) = 14.7
PDB [P13]:  6GS4  6GS7   

224: Enzyme activity and structural features of three single-domain phloemcyclophilins from Brassica napus.
Hanhart P, Falke S, Garbe M, Rose V, Thiess M, Betzel C, Kehr J,
Sci Rep. 2019 Jun 27;9(1):9368.
DOI: 10.1038/s41598-019-45856-y  |   PUBMED: 31249367  |   IF(2022) = 5.0
PDB [P14]:  6HMZ   

223: Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
Merő B, Radnai L, Gógl G, Tőke O, Leveles I, Koprivanacz K, Szeder B, Dülk M, Kudlik G, Vas V, Cserkaszky A, Sipeki S, Nyitray L, Vértessy BG, Buday L.
J Biol Chem. (2019 Mar)294:4608-4620
DOI: 10.1074/jbc.ra118.004732  |   PUBMED: 30659095  |   IF(2018) = 4.1
PDB [P13]:  5NP2  5NP5  5NP3   

222: Diamondoid Amino Acid-Based Peptide Kinase A Inhibitor Analogues.
Muller J, Kirschner RA, Berndt JP, Wulsdorf T, Metz A, Hrdina R, Schreiner PR, Geyer A, Klebe G,
ChemMedChem. 2019 Mar 22;14(6):663-672. Epub 2019Feb 19.
DOI: 10.1002/cmdc.201800779  |   PUBMED: 30677243  |   IF(2018) = 3.0
PDB [P13]:  5OK3   

Number of publications for 2019: 66

2018

221: Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics byl,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis.
Libreros-Zuniga GA, Dos Santos Silva C, Salgado Ferreira R, Dias MVB,
ACS Infect Dis. 2019 Feb 8;5(2):260-271. Epub2018 Dec 28.
DOI: 10.1021/ACSINFECDIS.8B00244  |   PUBMED: 30556998  |   IF(2018) = 5.0
PDB [P13]:  6D4K   

220: Design of two-tail compounds with rotationally fixed benzenesulfonamide ring asinhibitors of carbonic anhydrases.
Zaksauskas A, Capkauskaite E, Jezepcikas L, Linkuviene V, Kisonaite M, Smirnov A, Manakova E, Grazulis S, Matulis D,
Eur J Med Chem. 2018 Aug 5;156:61-78. Epub2018 Jun 27.
DOI: 10.1016/J.EJMECH.2018.06.059  |   PUBMED: 30006175  |   IF(2018) = 4.8
PDB [P14]:  6G6T  6G7A  6G5L   

219: Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.
Scheide-Noeth JP, Rosen M, Baumstark D, Dietz H, Mueller TD,
J Mol Biol. 2018 Dec 7.
DOI: 10.1016/J.JMB.2018.11.029  |   PUBMED: 30529748  |   IF(2018) = 5.1
PDB [P13]:  6H41   

218: Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMalpha peptides.
Salinas N, Colletier JP, Moshe A, Landau M
Nat Commun. 2018 Aug 29;9(1):3512.
DOI: 10.1038/s41467-018-05490-0  |   PUBMED: 30158633  |   IF(2022) = 14.9
PDB [P14]:  6FHD   

217: Structural and functional characterization of a family GH53 beta-1,4-galactanase from Bacteroides thetaiotaomicron that facilitates degradation of prebioticgalactooligosaccharides.
Boger M, Hekelaar J, van Leeuwen SS, Dijkhuizen L, Lammerts van Bueren A,
J Struct Biol. 2018 Dec 13.
DOI: 10.1016/J.JSB.2018.12.002  |   PUBMED: 30553858  |   IF(2018) = 3.8
PDB [P13]:  6GPA   

216: Structure-based switch of regioselectivity in the flavin-dependent tryptophan6-halogenase Thal.
Moritzer AC, Minges H, Prior T, Frese M, Sewald N, Niemann HH,
J Biol Chem. 2018 Dec 17.
DOI: 10.1074/JBC.RA118.005393  |   PUBMED: 30559288  |   IF(2018) = 4.1
PDB [P13]:  6IB5  6H44  6H43   

215: The cost of long catalytic loops in folding and stability of the ALS-associatedprotein SOD1.
Yang F, Wang H, Logan DT, Mu X, Danielsson J, Oliveberg M,
J Am Chem Soc. 2018 Oct 25.
DOI: 10.1021/JACS.8B08141  |   PUBMED: 30359015  |   IF(2018) = 14.7
PDB [P14]:  6FLH   

214: The hit-and-return system enables efficient time-resolved serial synchrotron crystallography.
Schulz EC, Mehrabi P, Muller-Werkmeister HM, Tellkamp F, Jha A, Stuart W, Persch E, De Gasparo R, Diederich F, Pai EF, Miller RJD,
Nat Methods. 2018 Nov;15(11):901-904. Epub 2018Oct 30.
DOI: 10.1038/S41592-018-0180-2  |   PUBMED: 30377366  |   IF(2018) = 28.5
PDB [P14]:  6FSX  6GXH  6GXT   

213: Crystal structure of human mARC1 reveals its exceptional position amongeukaryotic molybdenum enzymes.
Kubitza C, Bittner F, Ginsel C, Havemeyer A, Clement B, Scheidig AJ, ORCID: 0000-0002-2382-8818,
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):11958-11963. Epub 2018 Nov 5.
DOI: 10.1073/pnas.1808576115  |   PUBMED: 30397129  |   IF(2019) = 9.4
PDB [P14]:  6FW2   

212: Characterization of the catalytic flexible loop in the dihydroorotase domain ofthe human multi-enzymatic protein CAD.
Del Cano-Ochoa F, Grande-Garcia A, Reverte-Lopez M, D'Abramo M, Ramon-Maiques S,
J Biol Chem. 2018 Oct 12.
DOI: 10.1074/JBC.RA118.005494  |   PUBMED: 30315107  |   IF(2018) = 4.1
PDB [P13]:  6HFS  6HFR  6HFQ  6HFP  6HFU  6HFK  6HFJ  6HFH  6HFN  6HFL   

211: Towards a comprehensive understanding of the structural dynamics of a bacterialditerpene synthase during catalysis.
Driller R, Janke S, Fuchs M, Warner E, Mhashal AR, Major DT, Christmann M, Bruck T, Loll B
Nat Commun. 2018 Sep 28;9(1):3971.
DOI: 10.1038/S41467-018-06325-8  |   PUBMED: 30266969  |   IF(2022) = 14.9
PDB [P14]:  6GGL   

210: Recognition of modified cytosine variants by the DNA-binding domain ofmethyl-directed endonuclease McrBC.
Zagorskaite E, Manakova E, Sasnauskas G,
FEBS Lett. 2018 Sep 8.
DOI: 10.1002/1873-3468.13244  |   PUBMED: 30194838  |   IF(2018) = 2.7
PDB [P13]:  6GCF   

209: DNA recognition by Arabidopsis transcription factors ABI3 and NGA1
Sasnauskas G, Manakova E, Lapenas K, Kauneckaite K, Siksnys V
FEBS J. 2018 Nov;285(21):4041-4059.
DOI: 10.1111/febs.14649. Epub 2018 Sep 21.  |   PUBMED: 30183137.  |   IF(2018) = 4.7
PDB [P14]:  5OS9   

208: Tripeptide binding in a proton-dependent oligopeptide transporter.
Martinez Molledo M, Quistgaard EM, Low C,
FEBS Lett. 2018 Sep 8.
DOI: 10.1002/1873-3468.13246  |   PUBMED: 30194725  |   IF(2018) = 2.7
PDB [P14]:  6GHJ   

207: Crystal Structure of the Escherichia coli DExH-Box NTPase HrpB.
Pietrzyk-Brzezinska AJ, Absmeier E, Klauck E, Wen Y, Antelmann H, Wahl MC,
Structure. 2018 Aug 13.
DOI: 10.1016/J.STR.2018.07.013  |   PUBMED: 30174149  |   IF(2022) = 5.0
PDB [P14]:  6EUD   

206: Intriguing role of water in protein-ligand binding studied by neutroncrystallography on trypsin complexes.
Schiebel J, Gaspari R, Wulsdorf T, Ngo K, Sohn C, Schrader TE, Cavalli A, Ostermann A, Heine A, Klebe G
Nat Commun. 2018 Sep 3;9(1):3559.
DOI: 10.1038/s41467-018-05769-2  |   PUBMED: 30177695  |   IF(2022) = 14.9
PDB [P14]:  5MNE  5MNN  5MNG  5MNQ  5MNF  5MNH  5MOP  5MOQ  5MOS   

205: Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic SubunitQTRT1.
Johannsson S, Neumann P, Ficner R,
Biomolecules. 2018 Aug 24;8(3).
DOI: 10.3390/BIOM8030081  |   PUBMED: 30149595  |   IF(2019) = 4.7
PDB [P14]:  6H45  6H42   

204: Structural and Functional Characterization of the BcsG Subunit of the CelluloseSynthase in Salmonella typhimurium.
Sun L, Vella P, Schnell R, Polyakova A, Bourenkov G, Li F, Cimdins A, Schneider TR, Lindqvist Y, Galperin MY, Schneider G, Romling U,
J Mol Biol. 2018 Jul 12.
DOI: 10.1016/j.jmb.2018.07.008  |   PUBMED: 30017920  |   IF(2018) = 5.1
PDB [P14]:  5OLT   

203: Activity and structure of EcoKMcrA.
Czapinska H, Kowalska M, Zagorskaite E, Manakova E, Slyvka A, Xu SY, Siksnys V, Sasnauskas G, Bochtler M,
Nucleic Acids Res. 2018 Aug 10.
DOI: 10.1093/nar/gky731.  |   PUBMED: 30107581  |   IF(2018) = 11.1
PDB [P13]:  5OJH  6GHC   

202: NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward theEPHrin Family.
Troster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Muller S, Kuster B, Medard G, Kudlinzki D, Schwalbe H,
ChemMedChem. 2018 Jun 21.
DOI: 10.1002/CMDC.201800398  |   PUBMED: 29928781  |   IF(2018) = 3.0
PDB [P13]:  6FNF  6FNH  6FNG   

201: Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Sokolov AV, Dadinova LA, Petoukhov MV, Bourenkov G, Dubova KM, Amarantov SV, Volkov VV, Kostevich VA, Gorbunov NP, Grudinina NA, Vasilyev VB, Samygina VR,
Biochemistry (Mosc). 2018 Jun;83(6):701-707.
DOI: 10.1134/S000629791806007X  |   PUBMED: 30195326
PDB [P14]:  6FVE   

200: Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiencyby the tRNA nucleoside queuosine.
Johannsson S, Neumann P, Wulf A, Welp LM, Gerber HD, Krull M, Diederichsen U, Urlaub H, Ficner R,
Sci Rep. 2018 Jun 11;8(1):8880.
DOI: 10.1038/S41598-018-27118-5  |   PUBMED: 29892076  |   IF(2022) = 5.0
PDB [P13]:  6FDF   

199: Structural and functional insights into the unique CBS-CP12 fusion protein familyin cyanobacteria.
Hackenberg C, Hakanpaa J, Cai F, Antonyuk S, Eigner C, Meissner S, Laitaoja M, Janis J, Kerfeld CA, Dittmann E, Lamzin VS,
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7141-7146. Epub 2018 Jun 18.
DOI: 10.1073/pnas.1806668115  |   PUBMED: 29915055  |   IF(2019) = 9.4
PDB [P13]:  5NPL  5NVD  5NMU   

198: Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Schmidt K, Gardill BR, Kern A, Kirchweger P, Borsch M, Muller YA,
Proc Natl Acad Sci U S A. 2018 May 14.
DOI: 10.1073/PNAS.1716666115  |   PUBMED: 29760101  |   IF(2019) = 9.4
PDB [P14]:  5OM3  5OM5   

197: Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.
Peterson K, Kumar R, Stenstrom O, Verma P, Verma PR, Hakansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ,
J Med Chem. 2018 Feb 8;61(3):1164-1175. Epub2018 Jan 11.
DOI: 10.1021/ACS.JMEDCHEM.7B01626  |   PUBMED: 29284090  |   IF(2018) = 6.1
PDB [P13]:  5ODY   

196: Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus.
Kubitza C, Faust A, Gutt M, ORCID: 0000-0001-5629-7665, Gath L, Ober D, Scheidig AJ,
Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):422-432. Epub 2018 Apr 24.
DOI: 10.1107/S2059798318003510.  |   PUBMED: 29717713  |   IF(2018) = 3.2
PDB [P14]:  5NMX  5NMW   

195: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
Jensen RK, Pihl R, Gadeberg TAF, Jensen JK, Andersen KR, Thiel S, Laursen NS, Andersen GR,
J Biol Chem. 2018 Apr 27;293(17):6269-6281. Epub2018 Mar 1.
DOI: 10.1107/S1600576717014479  |   PUBMED: 29497000  |   IF(2018) = 4.1
PDB [P14]:  6EHG   

194: Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors.
Pernigo S, Chegkazi MS, Yip YY, Treacy C, Glorani G, Hansen K, Politis A, Bui S, Dodding MP, Steiner RA
Elife. 2018 Oct 15;7.
DOI: 10.7554/eLife.38362  |   PUBMED: 30320553  |   IF(2018) = 7.6
PDB [P14]:  6FUZ   

193: p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P
Nat Commun. 2018 Mar 9;9(1):1017.
DOI: 10.1107/S1600576717014479  |   PUBMED: 29523821  |   IF(2022) = 14.9
PDB [P14]:  6EIH   

192: The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific.
Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Sturzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C,
J Virol. 2018 May 9.
DOI: 10.1128/JVI.00226-18.  |   PUBMED: 29743357  |   IF(2018) = 4.3
PDB [P14]:  6GFC   

191: Multispecific Substrate Recognition in a Proton-Dependent OligopeptideTransporter.
Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Low C,
Structure. 2018 Mar 6;26(3):467-476.e4. Epub 2018Feb 8.
DOI: 10.1016/j.str.2018.01.005  |   PUBMED: 29429879  |   IF(2022) = 5.0
PDB [P14]:  5OXK  5OXP  5OXO  5OXN  6EIA  5OXQ   

190: Structural basis of DNA target recognition by the B3 domain of Arabidopsisepigenome reader VAL1.
Sasnauskas G, Kauneckaite K, Siksnys V
Nucleic Acids Res. 2018 Apr 6.
DOI: 10.1093/NAR/GKY256  |   PUBMED: 29660015  |   IF(2018) = 11.1
PDB [P14]:  6FAS   

189: The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1helicase-like motor.
Toliusis P, Tamulaitiene G, Grigaitis R, Tuminauskaite D, Silanskas A, Manakova E, Venclovas C, Szczelkun MD, Siksnys V, Zaremba M,
Nucleic Acids Res. 2018 Mar 16;46(5):2560-2572.
DOI: 10.1093/NAR/GKY107  |   PUBMED: 29471489  |   IF(2018) = 11.1
PDB [P14]:  6F1S   

188: A family of unconventional deubiquitinases with modular chain specificitydeterminants.
Hermanns T, Pichlo C, Woiwode I, Klopffleisch K, Witting KF, Ovaa H, Baumann U, Hofmann K
Nat Commun. 2018 Feb 23;9(1):799.
DOI: 10.1038/S41467-018-03148-5  |   PUBMED: 29476094  |   IF(2022) = 14.9
PDB [P13]:  6EI1   

187: Structure Guided Lead Generation toward Nonchiral M. tuberculosis ThymidylateKinase Inhibitors.
Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Ainsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S
J Med Chem. 2018 Apr 12;61(7):2753-2775. Epub 2018 Mar 15.
DOI: 10.1021/ACS.JMEDCHEM.7B01570  |   PUBMED: 29510037  |   IF(2018) = 6.1
PDB [P14]:  5NR7   

186: Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1through DCC.
Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang JH, Meijers R
Neuron. 2018 Mar 21;97(6):1261-1267.e4. Epub2018 Mar 1.
DOI: 10.1016/J.NEURON.2018.02.010  |   PUBMED: 29503192  |   IF(2018) = 14.4
PDB [P14]:  6FKQ   

185: The structure of hydrogenase-2 from Escherichia coli: implications for H2-driven proton pumping.
Beaton SE, Evans RM, Finney AJ, Lamont CM, Armstrong FA, Sargent F, Carr SB
Biochem J. 2018 Apr 16;475(7):1353-1370.
DOI: 10.1042/BCJ20180053  |   PUBMED: 29555844
PDB [P14]:  6EHQ   

184: Epsin and Sla2 form assemblies through phospholipid interfaces.
Garcia-Alai MM, Heidemann J, Skruzny M, Gieras A, Mertens HDT, Svergun DI, Kaksonen M, Uetrecht C, Meijers R
Nat Commun. 2018 Jan 23;9(1):328.
DOI: 10.1038/S41467-017-02443-X  |   PUBMED: 29362354  |   IF(2022) = 14.9
PDB [P14]:  6ENR  5ONF  5ON7   

183: Transposase-DNA Complex Structures Reveal Mechanisms for ConjugativeTransposition of Antibiotic Resistance.
Rubio-Cosials A, Schulz EC, Lambertsen L, Smyshlyaev G, Rojas-Cordova C, Forslund K, Karaca E, Bebel A, Bork P, Barabas O
Cell. 2018 Mar 22;173(1):208-220.e20. Epub 2018 Mar 15.
DOI: 10.1016/J.CELL.2018.02.032  |   PUBMED: 29551265  |   IF(2018) = 36.2
PDB [P13]:  6EN1  6EN2  6EN0  6EMY  6EMZ   

182: Structural basis for PDZ domain interactions in the post-synaptic densityscaffolding protein Shank3.
Ponna SK, Ruskamo S, Myllykoski M, Keller C, Boeckers TM, Kursula P
J Neurochem. 2018 Feb 23.
DOI: 10.1111/JNC.14322  |   PUBMED: 29473168
PDB [P13]:  5OVV  5OVP   

181: Structure and stability of the Human respiratory syncytial virus M2-1 RNA-bindingcore domain reveals a compact and cooperative folding unit.
Molina IG, Josts I, Almeida Hernandez Y, Esperante S, Salgueiro M, Garcia Alai MM, de Prat-Gay G, Tidow H,
Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):23-30. Epub 2017 Dec 15.
DOI: 10.1107/S2053230X17017381  |   PUBMED: 29372904  |   IF(2019) = 0.97
PDB [P13]:  5NOH  5NKX   

180: Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.
Petrova OA, Mantsyzov AB, Rodina EV, Efimov SV, Hackenberg C, Hakanpää J, Klochkov VV, Lebedev AA, Chugunova AA, Malyavko AN, Zatsepin TS, Mishin AV, Zvereva MI, Lamzin VS, Dontsova OA, Polshakov VI.
Nucleic Acids Res. (2018 Feb)46:1525-1540
DOI: 10.1093/nar/gkx1275  |   PUBMED: 29294091  |   IF(2018) = 11.1
PDB [P13]:  5NPT   

179: Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus smallalarmone synthetase RelP.
Manav MC, Beljantseva J, Bojer MS, Tenson T, Ingmer H, Hauryliuk V, Brodersen DE,
J Biol Chem. 2018 Jan 11.
DOI: 10.1074/JBC.RA117.001374  |   PUBMED: 29326162  |   IF(2018) = 4.1
PDB [P13]:  6EWZ   

178: Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23Receptor Enables Recruitment of the Shared Receptor IL-12Rbeta1.
Bloch Y, Bouchareychas L, Merceron R, Skladanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN
Immunity. 2018 Jan 16;48(1):45-58.e6. Epub2017 Dec 26.
DOI: 10.1016/J.IMMUNI.2017.12.008  |   PUBMED: 29287995  |   IF(2018) = 21.5
PDB [P14]:  5NJD  5MXA  5MZV  5M85   

177: Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Dolot R, Lam CH, Sierant M, Zhao Q, Liu FW, Nawrot B, Egli M, Yang X
Nucleic Acids Res. 2018 May 18;46(9):4819-4830.
DOI: 10.1093/nar/gky268.  |   PUBMED: 29684204  |   IF(2018) = 11.1
PDB [P13]:  6EO6   

176: Structure of the mouse acidic amino acid decarboxylase GADL1.
Raasakka A, Mahootchi E, Winge I, Luan W, Kursula P, Haavik J,
Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):65-73. Epub 2018 Jan 1.
DOI: 10.1107/S2053230X17017848  |   PUBMED: 29372909  |   IF(2019) = 0.97
PDB [P13]:  6ENZ   

175: The dual role of MamB in magnetosome membrane assembly and magnetite biomineralization.
Plitzko JM, Schüler D, Zarivach R
Mol Microbiol. 2018 Feb;107(4):542-557.
DOI: 10.1111/mmi.13899.  |   PUBMED: 29243866.  |   IF(2018) = 3.6
PDB [P13]:  5HOK   

174: Crystal structure correlations with the intrinsic thermodynamics of humancarbonic anhydrase inhibitor binding.
Smirnov A, Zubriene A, Manakova E, Grazulis S, Matulis D,
PeerJ. 2018 Feb 26;6:e4412. eCollection 2018.
DOI: 10.7717/PEERJ.4412  |   PUBMED: 29503769
PDB [P14]:  5LLP  5MSB  5LLO  5LLG  5LLC  5OGO   

173: Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent-Exposed Ribose-33 Pocket of tRNA-Guanine Transglycosylase.
Movsisyan LD, Schafer E, Nguyen A, Ehrmann FR, Schwab A, Rossolini T, Zimmerli D, Wagner B, Daff H, Heine A, Klebe G, Diederich F,
Chemistry. 2018 Jul 11;24(39):9957-9967.
DOI: 10.1002/chem.201801756  |   PUBMED: 29939431  |   IF(2019) = 4.9
PDB [P14]:  5JSW  5JSV   

172: Crystal structure of a novel domain of the motor subunit of the Type I restriction enzyme EcoR124 involved in complex assembly and DNA binding.
Grinkevich P, Sinha D, Iermak I, Guzanova A, Weiserova M, Ludwig J, Mesters JR, Ettrich RH.
J Biol Chem. 2018 Sep 28;293(39):15043-15054.
DOI: 10.1074/jbc.RA118.003978. Epub 2018 Jul 27.  |   PUBMED: 30054276  |   IF(2018) = 4.1
PDB [P13]:  5J3N   

Number of publications for 2018: 50

2017

171: Molecular basis of the 14-3-3 protein-dependent activation of yeast neutraltrehalase Nth1.
Alblova M, Smidova A, Docekal V, Vesely J, Herman P, Obsilova V, Obsil T,
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9811-E9820. Epub 2017 Oct 30.
DOI: 10.1073/PNAS.1714491114  |   PUBMED: 29087344  |   IF(2019) = 9.4
PDB [P13]:  5JTA   

170: Urease Inhibition in the Presence of N-(n-Butyl)thiophosphoric Triamide, aSuicide Substrate: Structure and Kinetics.
Mazzei L, Cianci M, Contaldo U, Musiani F, Ciurli S
Biochemistry. 2017 Oct 10;56(40):5391-5404. Epub 2017 Sep 15.
DOI: 10.1021/ACS.BIOCHEM.7B00750  |   PUBMED: 28857549  |   IF(2018) = 3.0
PDB [P13]:  5OL4   

169: PROTEIN CRYSTALS IR LASER ABLATED FROM AQUEOUS SOLUTION AT HIGH SPEED RETAIN THEIR DIFFRACTIVE PROPERTIES: APPLICATIONS IN HIGH-SPEED SERIAL CRYSTALLOGRAPHY.
E.C.SCHULZ,J.KAUB,F.BUSSE,P.MEHRABI,H.M.MULLER-WERKMEISTER, E.F.PAI,W.D.ROBERTSON,R.J.D.MILLER
J Appl Crystallogr. 50:1773 2017
DOI: 10.1107/S1600576717014479  |   PUBMED:
PDB [P14]:  5NYV  5O2G   

168: Crystal structure of a marine glycoside hydrolase family 99-related proteinlacking catalytic machinery.
Robb CS, Mystkowska AA, Hehemann JH
Protein Sci. 2017 Dec;26(12):2445-2450. Epub 2017 Nov 21.
DOI: 10.1002/PRO.3291  |   PUBMED: 28884852  |   IF(2018) = 2.4
PDB [P13]:  5NGW   

167: Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of ProteinKinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2alpha andIts Paralog CK2alpha'.
Hochscherf J, Lindenblatt D, Witulski B, Birus R, Aichele D, Marminon C, Bouaziz Z, Le Borgne M, Jose J, Niefind K
Pharmaceuticals (Basel). 2017 Dec 13;10(4).
DOI: 10.3390/PH10040098  |   PUBMED: 29236079
PDB [P13]:  5OOI   

166: Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic.
Samygina VR, Sokolov AV, Bourenkov G, Schneider TR, Anashkin VA, Kozlov SO, Kolmakov NN, Vasilyev VB,
Metallomics. 2017 Dec 1;9(12):1828-1838. Epub 2017 Nov27.
DOI: 10.1039/C7MT00157F  |   PUBMED: 29177316
PDB [P14]:  5N4L  5N2K   

165: A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site.
Mamais M, Degli Esposti A, Kouloumoundra V, Gustavsson T, Monti F, Venturini A, Chrysina ED, Markovitsi D, Gimisis T
Chemistry. 2017 Jul 3;23(37):8800-8805 Epub 2017Jun 19.
DOI: 10.1002/CHEM.201701591  |   PUBMED: 28493496  |   IF(2019) = 4.9
PDB [P14]:  5MEM   

164: Crystal structure and catalytic characterization of the dehydrogenase/reductaseSDR family member 4 (DHRS4) from Caenorhabditis elegans.
Kisiela M, Faust A, Ebert B, Maser E, Scheidig AJ,
FEBS J. 2017 Nov 19.
DOI: 10.1111/FEBS.14337  |   PUBMED: 29151266  |   IF(2018) = 4.7
PDB [P14]:  5OJG  5OJI   

163: Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a uniquedimeric structure.
Perveen S, Rashid N, Tang XF, Imanaka T, Papageorgiou AC
FEBS Open Bio. 2017 Jul 24;7(8):1217-1230.
DOI: 10.1002/2211-5463.12264  |   PUBMED: 28781961
PDB [P13]:  5NOF   

162: Crystal structures of serum albumins from domesticated ruminants and theircomplexes with 3,5-diiodosalicylic acid.
Bujacz A, Talaj JA, Zielinski K, Pietrzyk-Brzezinska AJ, Neumann P,
Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):896-909.
DOI: 10.1107/S205979831701470X  |   PUBMED: 29095162  |   IF(2018) = 3.2
PDB [P13]:  5ORF   

161: Crystal structure of the Legionella pneumophila Lpg2936 in complex with thecofactor S-adenosyl-L-methionine reveals novel insights into the mechanism ofRsmE family methyltransferases.
Pinotsis N, Waksman G,
Protein Sci. 2017 Sep 22.
DOI: 10.1002/PRO.3305  |   PUBMED: 28940762  |   IF(2018) = 2.4
PDB [P13]:  5O96   

160: Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction.
Stranava M, Man P, Skálová T, Kolenko P, Blaha J, Fojtikova V, Martínek V, Dohnálek J, Lengalova A, Rosůlek M, Shimizu T, Martínková M
J Biol Chem. 2017 Dec 22;292(51):20921-20935.
DOI: 10.1074/jbc.M117.817023. Epub 2017 Nov 1.  |   PUBMED: 29092908  |   IF(2018) = 4.1
PDB [P13]:  5OHF   

159: Dynamic control of RSK complexes by phosphoswitch-based regulation.
Gogl G, Biri-Kovacs B, Poti AL, Vadaszi H, Szeder B, Bodor A, Schlosser G, Acs A, Turiak L, Buday L, Alexa A, Nyitray L, Remenyi A,
FEBS J. 2017 Oct 30.
DOI: 10.1111/FEBS.14311  |   PUBMED: 29083550  |   IF(2018) = 4.7
PDB [P14]:  5N7D   

158: Structural Basis of the Selectivity of GenN, an AminoglycosideN-Methyltransferase Involved in Gentamicin Biosynthesis.
Bury PDS, Huang F, Li S, Sun Y, Leadlay PF, Dias MVB
ACS Chem Biol. 2017 Oct 9.
DOI: 10.1021/ACSCHEMBIO.7B00466  |   PUBMED: 28876898  |   IF(2019) = 4.43
PDB [P13]:  5TYQ  5U4T  5U19   

157: Mechanism of RNA polymerase II stalling by DNA alkylation
Malvezzi S, Farnung L, Aloisi CMN, Angelov T, Cramer P, Sturla SJ
Proc Natl Acad Sci U S A. 2017 Oct 30.
DOI: 10.1073/PNAS.1706592114  |   PUBMED: 29087308   |   IF(2019) = 9.4
PDB [P13]:  5OT2   

156: UbaLAI is a monomeric Type IIE restriction enzyme.
Sasnauskas G, Tamulaitiene G, Tamulaitis G, Calyseva J, Laime M, Rimseliene R, Lubys A, Siksnys V,
Nucleic Acids Res. 2017 Sep 19;45(16):9583-9594.
DOI: 10.1093/NAR/GKX634  |   PUBMED: 28934493  |   IF(2018) = 11.1
PDB [P13]:  5O63   

155: Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Hansen SB, Laursen NS, Andersen GR, Andersen KR,
Acta Crystallogr D Struct Biol. 2017 Oct 1;73(Pt 10):804-813. Epub 2017 Sep 27.
DOI: 10.1107/S2059798317013171  |   PUBMED: 28994409  |   IF(2018) = 3.2
PDB [P13]:  5NM0  5NML   

154: Lysozyme's lectin-like characteristics facilitates its immune defense function
Zhang R, Wu L, Eckert T, Burg-Roderfeld M, Rojas-Macias MA, Lüttek T, Krylov VB, Argunov DA, Datta A, Markart P, Guenther, A.; Norden, B.; Schauer, R.; Bhunia, A.; Enani, M. A.; Billeter, M.; Scheidig, A. J.; Nifantiev, N. E.; Siebert, H.-C.
Q Rev Biophys. 2017, 50.
DOI: 10.1017/S0033583517000075  |   PUBMED: 29233221  |   IF(2018) = 6.6
PDB [P13]:  5LSH   

153: Mechanistic insights into cyclic peptide generation by DnaE split-inteins throughquantitative and structural investigation.
Kick L, Harteis S, Koch MF, Schneider S,
ChemBioChem. 2017 Sep 15.
DOI: 10.1002/CBIC.201700503  |   PUBMED: 28914478  |   IF(2018) = 2.6
PDB [P14]:  5OL5   

152: The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery.
Prevost MS, Pinotsis N, Dumoux M, Hayward RD, Waksman G,
Sci Rep. 2017 Aug 25;7(1):9450.
DOI: 10.1038/S41598-017-10249-6  |   PUBMED: 28842705  |   IF(2022) = 5.0
PDB [P13]:  5NNY   

151: Structures of designed armadillo repeat proteins binding to peptides fused toglobular domains.
Hansen S, Kiefer JD, Madhurantakam C, Mittl PRE, Pluckthun A,
Protein Sci. 2017 Jul 10
DOI: 10.1002/PRO.3229  |   PUBMED: 28691351  |   IF(2018) = 2.4
PDB [P14]:  5MFD   

150: Mechanism of Transcription Anti-termination in Human Mitochondria.
Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D,
Cell. 2017 Oct 7.
DOI: 10.1016/J.CELL.2017.09.035  |   PUBMED: 29033127   |   IF(2018) = 36.2
PDB [P13]:  5OL9   

149: Structural Basis for Mitotic Centrosome Assembly in Flies.
Feng Z, Caballe A, Wainman A, Johnson S, Haensele AFM, Cottee MA, Conduit PT, Lea SM, Raff JW,
Cell. 2017 Jun 1;169(6):1078-1089.e13.
DOI: 10.1016/J.CELL.2017.05.030  |   PUBMED: 28575671  |   IF(2018) = 36.2
PDB [P13]:  5MW9  5MW0   

148: Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases
E.CAPKAUSKAITE,V.LINKUVIENE,A.SMIRNOV,G.MILINAVICIUTE,D.TIMM,A.KASILIAUSKAITE,E.MANAKOVA,S.GRAZULIS,D.MATULIS
Chemistry Select. 2017 2:5360-5371
DOI: 10.1002/SLCT.201700531  |   PUBMED:
PDB [P13]:  5LL4  5LL5  5LL9  5LLA   

147: Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and KainateReceptors.
Mollerud S, Pinto A, Marconi L, Frydenvang K, Thorsen TS, Laulumaa S, Venskutonyte R, Winther S, Moral AMC, Tamborini L, Conti P, Pickering DS, Kastrup JS
ACS Chem Neurosci. 2017 Jul 21.
DOI: 10.1021/ACSCHEMNEURO.7B00201  |   PUBMED: 28691798  |   IF(2019) = 4.5
PDB [P14]:  5NEB   

146: Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhard V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M, Schwalbe H, Kuster B, Medard G,
ChemMedChem. 2017 May 24.
DOI: 10.1002/CMDC.201700217  |   PUBMED: 28544567  |   IF(2018) = 3.0
PDB [P13]:  5NKA  5NKB  5NKC  5NKD  5NK6  5NK8  5NK9   

145: Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by stericshielding and substrate fixation.
Newie J, Neumann P, Werner M, Mata RA, Ficner R, Feussner I
Sci Rep. 2017 May 18;7(1):2069.
DOI: 10.1038/S41598-017-02153-W  |   PUBMED: 28522865  |   IF(2022) = 5.0
PDB [P14]:  5MEG   

144: Structure of a soluble epoxide hydrolase identified in Trichoderma reesei.
Wilson C, De Oliveira GS, Adriani PP, Chambergo FS, Dias MVB,
Biochim Biophys Acta. 2017 May 11.
DOI: 10.1016/J.BBAPAP.2017.05.004  |   PUBMED: 28502798
PDB [P13]:  5URO   

143: Trapped intermediate state of plant pyruvate phosphate dikinase indicatessubsteps in catalytic swiveling domain mechanism.
Minges A, Hoppner A, Groth G,
Protein Sci. 2017 May 3.
DOI: 10.1002/PRO.3184  |   PUBMED: 28470715  |   IF(2018) = 2.4
PDB [P13]:  5LU4   

142: Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and2-Aminopyridine Become Protonated Upon Binding to Trypsin.
Schiebel J, Gaspari R, Sandner A, Ngo K, Gerber HD, Cavalli A, Ostermann A, Heine A, Klebe G
Angew Chem Int Ed Engl. 2017 Apr 18;56(17):4887-4890. Epub 2017 Mar 28.
DOI: 10.1002/ANIE.201701038  |   PUBMED: 28371253  |   IF(2019) = 13.0
PDB [P14]:  5MN1  5MNC  5MNB  5MON   

141: Core Mediator structure at 3.4 A extends model of transcription initiationcomplex.
Nozawa K, Schneider TR, Cramer P,
Nature. 2017 May 11;545(7653):248-251.
DOI: 10.1038/NATURE22328  |   PUBMED: 28467824  |   IF(2018) = 43.1
PDB [P14]:  5N9J   

140: EXPLAINING OPERATIONAL INSTABILITY OF AMINE TRANSAMINASES: SUBSTRATE-INDUCED INACTIVATION MECHANISM AND INFLUENCE OF QUATERNARY STRUCTURE ON ENZYME-COFACTOR INTERMEDIATE STABILITY.
T.BORNER,S.RAMISCH,E.REDDEM,S.BARTSCH,A.VOGEL, A.M.W.H.THUNNISSEN,P.ADLERCREUTZ,C.GREY
ACS Catalysis. 7:1259-1269 (2017)
DOI: 10.1021/ACSCATAL.6B02100  |   PUBMED:   |   IF(2018) = 12.1
PDB [P14]:  5LH9   

139: Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Mickeviciute A, Timm DD, Gedgaudas M, Linkuviene V, Chen Z, Waheed A, Michailoviene V, Zubriene A, Smirnov A, Capkauskaite E, Baranauskiene L, Jachno J, Revuckiene J, Manakova E, Grazulis S, Matuliene J, Di Cera E, Sly WS, Matulis D, ORCID: http://orcid.org/0000-0002-6178-6276,
Eur Biophys J. 2017 Oct 3.
DOI: 10.1007/S00249-017-1256-0  |   PUBMED: 28975383
PDB [P14]:  5IPZ   

138: Structure of the WipA protein reveals a novel tyrosine protein phosphataseeffector from Legionella pneumophila.
Pinotsis N, Waksman G
J Biol Chem. 2017 Jun 2;292(22):9240-9251. Epub2017 Apr 7.
DOI: 10.1074/JBC.M117.781948  |   PUBMED: 28389563  |   IF(2018) = 4.1
PDB [P13]:  5N6X   

137: Manszewski T, Szpotkowski K, Jaskolski M.
Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii.
IUCrJ. 2017 Apr 10;4(Pt 3):271-282. eCollection 2017 May 1.
DOI: 10.1107/S2052252517002433  |   PUBMED: 28512574  |   IF(2020) = 4
PDB [P13]:  5M67  5M5K   

136: Structural insights into reptarenavirus cap- snatching machinery
Rosenthal, M., Gogrefe, N., Vogel, D., Reguera, J., Rauschenberger, B., Cusack, S., Günther, S. & Reindl, S
PLoS Pathog. (2017) 13, e1006400-1006424.
DOI: 10.1371/journal.ppat.1006400  |   PUBMED: 28505175  |   IF(2018) = 6.1
PDB [P13]:  5MUZ  5MV0   

135: Crystal structure and biological implications of a glycoside hydrolase family 55 beta-1,3-glucanase from Chaetomium thermophilum.
Papageorgiou AC, Chen J, Li D,
Biochim Biophys Acta. 2017 May 4.
DOI: 10.1016/J.BBAPAP.2017.05.002  |   PUBMED: 28479293
PDB [P13]:  5M60   

134: Structural and functional innovations in the real-time evolution of new(betaalpha)8 barrel enzymes.
Newton MS, Guo X, Soderholm A, Nasvall J, Lundstrom P, Andersson DI, Selmer M, Patrick WM
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4727-4732. Epub 2017 Apr 17.
DOI: 10.1073/PNAS.1618552114  |   PUBMED: 28416687  |   IF(2019) = 9.4
PDB [P14]:  5L6U   

133: Functional and structural insight into properdin control of complement alternative pathway amplification.
Pedersen DV, Roumenina L, Jensen RK, Gadeberg TA, Marinozzi C, Picard C, Rybkine T, Thiel S, Sørensen UB, Stover C, Fremeaux-Bacchi V, Andersen GR.
EMBO J. 2017 Apr 13;36(8):1084-1099.
DOI: 10.15252/embj.201696173. Epub 2017 Mar 6.  |   PUBMED: 28264884   |   IF(2018) = 11.2
PDB [P14]:  PDB:   

132: Structural insights into the mechanism of the DEAH-box RNA helicase Prp43.
FTauchert MJ, Fourmann JB, Luhrmann R, Ficner R
Elife. 2017 Jan 16;6.
DOI: 10.7554/ELIFE.21510  |   PUBMED: 28092261  |   IF(2016) = 8.3
PDB [P13]:  5LTA  5LTK  5LTJ   

131: Structural aspects of nucleotide ligand binding by a bacterial 2Hphosphoesterase.
Myllykoski M, Kursula P,
PLoS One. 2017 Jan 31;12(1):e0170355.
DOI: 10.1371/JOURNAL.PONE.0170355  |   PUBMED: 28141848  |   IF(2014) = 3.23
PDB [P13]:  5LDQ   

130: Inactivation of urease by catechol: Kinetics and structure.
Mazzei L, Cianci M, Musiani F, Lente G, Palombo M, Ciurli S,
J Inorg Biochem. 2017 Jan;166:182-189. Epub2016 Nov 9.
DOI: 10.1016/J.JINORGBIO.2016.11.016  |   PUBMED: 27888701
PDB [P13]:  5G4H   

129: Evaluating the Contribution of Transition-State Destabilization to Changes in theResidence Time of Triazole-Based InhA Inhibitors.
Spagnuolo LA, Eltschkner S, Yu W, Daryaee F, Davoodi S, Knudson SE, Allen EK, Merino J, Pschibul A, Moree B, Thivalapill N, Truglio JJ, Salafsky J, Slayden RA, Kisker C, Tonge PJ,
J Am Chem Soc. 2017 Feb 22.
DOI: 10.1021/JACS.6B11148  |   PUBMED: 28151657  |   IF(2015) = 13.0
PDB [P13]:  5MTQ   

128: Architecture and mechanism of the late endosomal Rab7-like Ypt7 guaninenucleotide exchange factor complex Mon1-Ccz1.
Kiontke S, Langemeyer L, Kuhlee A, Schuback S, Raunser S, Ungermann C, Kummel D,
Nat Commun. 2017 Jan 4;8:14034.
DOI: 10.1038/NCOMMS14034  |   PUBMED: 28051187  |   IF(2015) = 11.3
PDB [P13]:  5LDD   

127: Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
Peng B, Thorsell AG, Karlberg T, Schuler H, Yao SQ,
Angew Chem Int Ed Engl. 2017 Jan 2;56(1):248-253. Epub 2016 Dec 5.
DOI: 10.1002/ANIE.201609655  |   PUBMED: 27918638  |   IF(2015) = 11.7
PDB [P13]:  5LYH   

126: Collapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, andconformational flexibility.
Myllykoski M, Baumann A, Hensley K, Kursula P
Amino Acids. 2017 Jan 2.
DOI: 10.1007/S00726-016-2376-Z  |   PUBMED: 28044206  |   IF(2016) = 3.2
PDB [P13]:  5LXX   

125: Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to
Zubriene A, Smirnov A, Dudutiene V, Timm DD, Matuliene J, Michailoviene V, Zakšauskas A, Manakova E, Gražulis S, Matulis D
Carbonic Anhydrases. ChemMedChem. 2017 Jan 20;12(2):161-176.
DOI: 10.1002/cmdc.201600509. Epub 2016 Dec 21.  |   PUBMED: 28001003.
PDB [P14]:  5E2M  5E2N  5DRS  5DOH   

124: Glucose-1-phosphate uridylyltransferase from Erwinia amylovora: Activity, structure and substrate specificity.
Benini S, Toccafondi M, Rejzek M, Musiani F, Wagstaff BA, Wuerges J, Cianci M, Field RA.
Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt A):1348-1357.
DOI: 10.1016/j.bbapap.2017.08.015. Epub 2017 Aug 24.  |   PUBMED: 28844747.
PDB [P13]:  4D48   

Number of publications for 2017: 48

2016

123: Structural Analysis of beta-Fructofuranosidase from Xanthophyllomyces dendrorhousReveals Unique Features and the Crucial Role of N-Glycosylation inOligomerization and Activity.
Ramirez-Escudero M, Gimeno-Perez M, Gonzalez B, Linde D, Merdzo Z, Fernandez-Lobato M, Sanz-Aparicio J,
J Biol Chem. 2016 Mar 25;291(13):6843-57. Epub 2016Jan 28.
DOI: 10.1074/JBC.M115.708495  |   PUBMED: 26823463  |   IF(2018) = 4.1
PDB [P13]:  5FKB  5FMB  5FKC   

122: Ferrocene-Biotin Conjugates: Synthesis, Structure, Cytotoxic Activity and Interaction with Avidin
Blauz, A., Rychlik, B., Makal, A., Szulc, K., Strzelczyk, P., Bujacz, G., Zakrzewski, J., Wozniak, K., Plazuk, D.
Chempluschem 81: 1191-1201 (2016)
DOI: 10.1002/cplu.201600320  |   PUBMED:
PDB [P13]:  5HLM   

121: Structural and Catalytic Properties of S1 Nuclease from Aspergillus oryzae Responsible for Substrate Recognition, Cleavage, Non-Specificity, and Inhibition.
Koval T, Ostergaard LH, Lehmbeck J, Norgaard A, Lipovova P, Duskova J, Skalova T, Trundova M, Kolenko P, Fejfarova K, Stransky J, Svecova L, Hasek J, Dohnalek J,
PLoS One. 2016 Dec 30;11(12):e0168832. eCollection 2016.
DOI: 10.1371/JOURNAL.PONE.0168832  |   PUBMED: 28036383  |   IF(2018) = 2.8
PDB [P13]:  5FB9   

120: First Structure-Activity Relationship of 17beta-Hydroxysteroid Dehydrogenase Type14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.
Braun F, Bertoletti N, Moller G, Adamski J, Steinmetzer T, Salah M, Abdelsamie AS, van Koppen CJ, Heine A, Klebe G, Marchais-Oberwinkler S,
J Med Chem. 2016 Dec 8;59(23):10719-10737. Epub 2016 Nov 18.
DOI: 10.1021/ACS.JMEDCHEM.6B01436  |   PUBMED: 27933965  |   IF(2014) = 5.4
PDB [P13]:  5L7T  5L7Y   

119: Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNAhelicase Brr2.
Absmeier E, Becke C, Wollenhaupt J, Santos KF, Wahl MC,
Cell Cycle. 2016 Nov 23:1-13.
DOI: 10.1080/15384101.2016.1255384  |   PUBMED: 27880071
PDB [P13]:  5M59   

118: Structural basis of myelin-associated glycoprotein adhesion and signalling.
Pronker MF, Lemstra S, Snijder J, Heck AJ, Thies-Weesie DM, Pasterkamp RJ, Janssen BJ
Nat Commun. 2016 Dec 6;7:13584.
DOI: 10.1038/NCOMMS13584  |   PUBMED: 27922006  |   IF(2022) = 14.9
PDB [P14]:  5LFU   

117: Structural Characterization of the Avidin Interactions with Fluorescent Pyrene-Conjugates: 1-Biotinylpyrene and 1-Desthiobiotinylpyrene.
Strzelczyk P, Plazuk D, Zakrzewski J, Bujacz G
Molecules. 2016 Sep 27;21(10).
DOI: 10.3390/MOLECULES21101270  |   PUBMED: 27689976  |   IF(2015) = 2.5
PDB [P13]:  5IRU  5IRW   

116: Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance.
Barber-Zucker S, Uebe R, Davidov G, Navon Y, Sherf D, Chill JH, Kass I, Bitton R, Schuler D, Zarivach R
Sci Rep. 2016 Aug 23;6:31933.
DOI: 10.1038/SREP31933  |   PUBMED: 27550551  |   IF(2015) = 5.2
PDB [P13]:  5HSP   

115: Structural and functional characterization of a ruminal beta-glycosidase defines a novel subfamily of glycosyl hydrolase family 3 with permuted domain topology.
Ramirez-Escudero M, Del Pozo MV, Marin-Navarro J, Gonzalez B, Golyshin PN, Polaina J, Ferrer M, Sanz-Aparicio J
J Biol Chem. 2016 Sep 27.
DOI: 10.1074/JBC.M116.747527  |   PUBMED: 27679487  |   IF(2014) = 4.57
PDB [P13]:  5K6M   

114: A multicrystal diffraction data-collection approach for studying structural dynamics with millisecond temporal resolution.
Schubert R, Kapis S, Gicquel Y, Bourenkov G, Schneider TR, Heymann M, Betzel C, Perbandt M
IUCrJ. 2016 Oct 26;3(Pt 6):393-401. eCollection 2016 Nov 1.
DOI: 10.1107/S2052252516016304  |   PUBMED: 27840678  |   IF(2016) = 5.31
PDB [P14]:  5EN4  5M62  5LH7  5EUV  5C9O  5C9L  5LMH  5LN0  5JXQ  5LH6  5LH5  5LH3  5LH1  5LH0  5F5V  5A62  5D4W  5F5T   

113: Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs.
Heinzlmeir S, Kudlinzki D, Sreeramulu S, Klaeger S, Gande SL, Linhard V, Wilhelm M, Qiao H, Helm D, Ruprecht B, Saxena K, Medard G, Schwalbe H, Kuster B,
ACS Chem Biol. 2016 Oct 21.
DOI: 10.1021/ACSCHEMBIO.6B00709  |   PUBMED: 27768280  |   IF(2014) = 5.3
PDB [P13]:  5IA4  5I9W  5I9Y  5I9X  5I9Z  5IA5  5IA1  5I9V   

112: The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Dahms SO, Creemers JW, Schaub Y, Bourenkov GP, Zogg T, Brandstetter H, Than ME
Sci Rep. 2016 Sep 27;6:34303.
DOI: 10.1038/SREP34303  |   PUBMED: 27670069  |   IF(2015) = 5.23
PDB [P13]:  5JMO   

111: Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptorGIF.
Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN
Nat Commun. 2016 Nov 7;7:13228.
DOI: 10.1038/NCOMMS13228  |   PUBMED: 27819269  |   IF(2015) = 11.3
PDB [P14]:  5D22  5D28   

110: Robotic QM/MM-driven maturation of antibody combining sites.
Smirnov IV, Golovin AV, Chatziefthimiou SD, Stepanova AV, Peng Y, Zolotareva OI, Belogurov AA Jr, Kurkova IN, Ponomarenko NA, Wilmanns M, Blackburn GM, Gabibov AG, Lerner RA
Sci Adv. 2016 Oct 19;2(10):e1501695. eCollection 2016 Oct.
DOI: 10.1126/SCIADV.1501695  |   PUBMED: 27774510  |   IF(2018) = 12.5
PDB [P14]:  5TJD  6Y1N  5ADO   

109: HU histone-like DNA-binding protein from Thermus thermophilus: structural andevolutionary analyses.
Papageorgiou AC, Adam PS, Stavros P, Nounesis G, Meijers R, Petratos K, Vorgias CE
Extremophiles. 2016 Jun 24.
DOI: 10.1007/S00792-016-0859-1  |   PUBMED: 27342116  |   IF(2014) = 2.34
PDB [P14]:  5EKA   

108: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
Schrader J, Henneberg F, Mata RA, Tittmann K, Schneider TR, Stark H, Bourenkov G, Chari A
Science. 2016 Aug 5;353(6299):594-8.
DOI: 10.1126/SCIENCE.AAF8993  |   PUBMED: 27493187  |   IF(2015) = 34.6
PDB [P14]:  5LE5  5LF1  5LF0  5LF3  5LF4  5LF6  5LF7  5LEX  5LEY  5LEZ   

107: Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.
Kasaragod VB, Schindelin H,
Structure. 2016 May 3;24(5):782-8. Epub 2016 Apr 21.
DOI: 10.1016/J.STR.2016.02.023  |   PUBMED: 27112598  |   IF(2014) = 5.62
PDB [P13]:  5ERV  5ERU   

106: Data collection with a tailored X-ray beam size at 2.69 A wavelength (4.6 keV):sulfur SAD phasing of Cdc23(Nterm).
Cianci M, Groves MR, Barford D, Schneider TR,
Acta Crystallogr D Struct Biol. 2016 Mar 1;72(Pt 3):403-12. Epub 2016 Mar 1.
DOI: 10.1016/j.ijbiomac.2016.02.047  |   PUBMED: 26960127  |   IF(2015) = 2.51
PDB [P13]:  5FTP   

105: Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase.
Clausen JD, Bublitz M, Arnou B, Olesen C, Andersen JP, Moller JV, Nissen P,
Structure. 2016 Apr 5;24(4):617-23.
DOI: 10.1016/J.STR.2016.02.018  |   PUBMED: 27050689  |   IF(2014) = 5.62
PDB [P14]:  5A3Q   

104: Molecular basis for inhibition of AcrB multidrug efflux pump by novel andpowerful pyranopyridine derivatives.
Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS, Ding X, Ornik AR, Ruggerone P, Bowlin TL, Nikaido H, Pos KM, Opperman TJ,
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3509-14. Epub 2016 Mar 14.
DOI: 10.1073/PNAS.1602472113  |   PUBMED: 26976576  |   IF(2015) = 9.74
PDB [P13]:  5ENT   

103: Inactivation of urease by 1,4-benzoquinone: chemistry at the protein surface.
Mazzei L, Cianci M, Musiani F, Ciurli S,
Dalton T. 2016 Apr 7;45(13):5455-9. Epub 2016 Mar10.
DOI: 10.1039/C6DT00652C  |   PUBMED: 26961812  |   IF(2015) = 4.19
PDB [P13]:  5FSE  5FSD   

102: Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases.
Molitor C, Mauracher SG, Rompel A
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1806-15. Epub 2016 Mar 14.
DOI: 10.1073/PNAS.1523575113  |   PUBMED: 26976571  |   IF(2015) = 9.74
PDB [P14]:  4Z0Y   

101: Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.
Drebes J, Kunz M, Windshugel B, Kikhney AG, Muller IB, Eberle RJ, Oberthur D, Cang H, Svergun DI, Perbandt M, Betzel C, Wrenger C
Sci Rep. 2016 Mar 10;6:22871.
DOI: 10.1038/SREP22871  |   PUBMED: 26960569  |   IF(2014) = 5.57
PDB [P14]:  5CGA  5CGE   

100: Crystallographic studies of the complex of human HINT1 protein with anon-hydrolyzable analog of Ap4A.
Dolot R, Kaczmarek R, Seda A, Krakowiak A, Baraniak J, Nawrot B
Int J Biol Macromol. 2016 Jun;87:62-9. Epub 2016 Feb 18.
DOI: 10.1016/J.IJBIOMAC.2016.02.047  |   PUBMED: 26905466  |   IF(2018) = 4.8
PDB [P13]:  4ZKL   

99: Sleeping Beauty transposase structure allows rational design of hyperactivevariants for genetic engineering.
Voigt F, Wiedemann L, Zuliani C, Querques I, Sebe A, Mates L, Izsvak Z, Ivics Z, Barabas O,
Nat Commun. 2016 Mar 30;7:11126.
DOI: 10.1038/NCOMMS11126  |   PUBMED: 27025571  |   IF(2014) = 11.4
PDB [P14]:  5CR4   

98: Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells.
Berneking L, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney AG, Koch-Nolte F, Buck F, Perbandt M, Betzel C, Svergun DI, Hentschke M, Aepfelbacher M,
PLoS Pathog. 2016 Jun 14;12(6):e1005660. eCollection 2016 Jun.
DOI: 10.1371/journal.ppat.1005660  |   PUBMED: 27300509  |   IF(2018) = 6.1
PDB [P14]:  4OW2   

97: Impact of the crystallization condition on importin-β conformation. Acta Crystallogr D
Tauchert MJ, Hémonnot C, Neumann P, Köster S, Ficner R, Dickmanns A
Struct Biol. 2016 Jun;72(Pt 6):705-17.
DOI: 10.1107/S2059798316004940  |   PUBMED: 27303791
PDB [P13]:  4XRI  4XRK   

96: Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangementfor phosphoryl transfer.
Weisse RH, Faust A, Schmidt M, Schonheit P, Scheidig AJ
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E519-28. Epub 2016 Jan 19.
DOI: 10.1073/PNAS.1518614113  |   PUBMED: 26787904  |   IF(2014) = 9.67
PDB [P14]:  5HBR  4YAK  4XYL  4YB8  4YBZ  4XYM   

95: Comprehensive Structural Characterization of the Bacterial HomospermidineSynthase-an Essential Enzyme of the Polyamine Metabolism.
Krossa S, Faust A, Ober D, Scheidig AJ,
Sci Rep. 2016 Jan 18;6:19501.
DOI: 10.1038/SREP19501  |   PUBMED: 26776105  |   IF(2014) = 5.6
PDB [P14]:  4TVB  4XRG  4XR4  4XQC  4XQE  4XQG   

94: Characterization and 1.57 A resolution structure of the key fire blight phosphatase AmsI from Erwinia amylovora.
Salomone-Stagni M, Musiani F, Benini S.
Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):903-910. Epub 2016 Nov 30.
DOI: 10.1107/S2053230X16018781  |   PUBMED: 27917839;   |   IF(2019) = 0.97
PDB [P13]:  4D74   

93: Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants
Stellmacher L, Sandalova T, Schneider S, Schneider G, Sprenger GA, Samland AK
Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):467-76.
DOI: 10.1107/S2059798316001170. Epub 2016 Mar 24.  |   PUBMED: 27050126  |   IF(2018) = 3.2
PDB [P13]:  4S2B   

92: Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris.
Rudolph K, Parthier C, Egerer-Sieber C, Geiger D, Muller YA, Kreis W, Muller-Uri F
Acta Crystallogr F Struct Biol Commun. 2016 Jan 1;72(Pt 1):16-23.
DOI: 10.1107/S2053230X15023043  |   PUBMED: 26750479  |   IF(2014) = 0.54
PDB [P13]:  5C05   

Number of publications for 2016: 32

2015

91: Structure of GPN-loop GTPase Npa3 and implications for RNA polymerase II assembly.
Niesser J,Wagner FR,Kostrewa D,Muhlbacher W,Cramer P
Mol Cell Biol. 2015 Dec 28.
DOI: 10.1128/MCB.01009-15  |   PUBMED: 26711263  |   IF(2015) = 4.77
PDB [P13]:  5HCN  5HCI   

90: The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs.
Kiliszek A, Banaszak K, Dauter Z, Rypniewski W
Nucleic Acids Res. 2015 Dec 29.
DOI: 10.1093/NAR/GKV1513  |   PUBMED: 26717983  |   IF(2015) = 9.12
PDB [P13]:  5EMF   

89: Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/IronCofactor.
Griese JJ, Kositzki R, Schrapers P, Branca RM, Nordstrom A, Lehtio J, Haumann M, Hogbom M
J Biol Chem. 2015 Oct 16;290(42):25254-72. Epub2015 Aug 31.
DOI: 10.1016/J.JINORGBIO.2016.04.019  |   PUBMED: 26324712  |   IF(2014) = 4.57
PDB [P13]:  5EKB   

88: The terminal phycobilisome emitter, LCM: A light-harvesting pigment with aphytochrome chromophore.
Tang K, Ding WL, Hoppner A, Zhao C, Zhang L, Hontani Y, Kennis JT, Gartner W, Scheer H, Zhou M, Zhao KH
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15880-5.
DOI: 10.1073/PNAS.1519177113  |   PUBMED: 26669441  |   IF(2014) = 9.67
PDB [P13]:  4XXI   

87: The large N-terminal region of the Brr2 RNA helicase guides productivespliceosome activation.
Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Preussner M, Heyd F, Urlaub H, Luhrmann R, Santos KF, Wahl MC
Gene Dev. 2015 Dec 15;29(24):2576-87. Epub 2015 Dec4.
DOI: 10.1101/GAD.271528.115  |   PUBMED: 26637280  |   IF(2014) = 12.6
PDB [P14]:  5DCA   

86: Structural Insights into the Competitive Binding of Diclofenac and Naproxen by Equine Serum Albumin.
Sekula B, Bujacz A
J Med Chem. 2015 Dec 23.
DOI: 10.1021/ACS.JMEDCHEM.5B00909  |   PUBMED: 26652101  |   IF(2014) = 5.4
PDB [P13]:  4ZBQ   

85: Structures of yeast peroxisomal Delta(3),Delta(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.
Onwukwe GU, Koski MK, Pihko P, Schmitz W, Wierenga RK
Acta Crystallogr D Biol Crystallogr. 2015 Nov 1;71(Pt 11):2178-91.
DOI: 10.1107/S139900471501559X  |   PUBMED: 26527136  |   IF(2018) = 3.2
PDB [P13]:  4ZDE  4ZDB   

84: Terahertz radiation induces non-thermal structural changes associated with Fröhlich condensation in a protein crystal.
Lundholm IV, Rodilla H, Wahlgren WY, Duelli A, Bourenkov G, Vukusic J, Friedman R, Stake J, Schneider T, Katona G.
Struct Dyn (2015 Sep)2:054702
DOI: 10.1063/1.4931825  |   PUBMED: 26798828
PDB [P14]:  5APC  5APE  5APD  5APF   

83: DETERMINANTS OF LIGAND BINDING AND ACTIVITY IN CNPASE
A.RAASAKKA,M.MYLLYKOSKI,M.LEHTIMAKI,P.KURSULA
Sci Rep. 2015 Nov 13;5:16520.
DOI: 10.1038/srep16520  |   PUBMED: 26563764  |   IF(2014) = 5.6
PDB [P14]:  4WC9  4WDH  4WEX  4WDF  4WDG  4WDA  4WDB  4WBL   

82: Kinetic and structural studies reveal a unique binding mode of sulfite to thenickel center in urease.
Mazzei L,Cianci M,Benini S,Bertini L,Musiani F,Ciurli S
J Inorg Biochem. 2015 Nov 5;154:42-49.
DOI: 10.1016/J.JINORGBIO.2015.11.003  |   PUBMED: 26580226
PDB [P13]:  5A6T   

81: Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of NaturalPolyphenols and their Metabolites.
Florio P, Folli C, Cianci M,Del Rio D,Zanotti G,Berni R
J Biol Chem. 2015 Oct 14.
DOI: 10.1074/JBC.M115.690172  |   PUBMED: 26468275  |   IF(2018) = 4.1
PDB [P13]:  5AL8  5AKS  5AKT  5AKV   

80: Open and closed states of Candida antarctica Lipase B: protonation and themechanism of interfacial activation.
Stauch B, Fisher SJ, Cianci M
J Lipid Res. 2015 Oct 7.
DOI: 10.1194/JLR.M063388  |   PUBMED: 26447231
PDB [P13]:  5A6V  5A71   

79: Structural studies of Helix aspersa agglutinin complexed with GalNAc: A lectin that serves as a diagnostic tool.
Pietrzyk AJ, Bujacz A, Mak P, Potempa B, Niedziela T
Int J Biol Macromol. 2015 Sep 28;81:1059-1068.
DOI: 10.1016/J.IJBIOMAC.2015.09.044  |   PUBMED: 26416237  |   IF(2018) = 4.8
PDB [P13]:  4Q56   

78: Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.
Luhavaya H, Dias MV, Williams SR, Hong H, de Oliveira LG, Leadlay PF
Angew Chem Int Ed Engl. 2015 Sep 17.
DOI: 10.1002/ANIE.201507090  |   PUBMED: 26377145  |   IF(2019) = 13.0
PDB [P13]:  5CXO   

77: Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1).
Karna N, Legowska A, Malicki S, Debowski D, Golik P, Gitlin A, Grudnik P, Wladyka B, Brzozowski K, Dubin G, Rolka K
ChemBioChem. 2015 Jul 25.
DOI: 10.1002/CBIC.201500296  |   PUBMED: 26212347  |   IF(2014) = 3.0
PDB [P13]:  4XOJ   

76: Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.
Oberthur D, Achenbach J, Gabdulkhakov A, Buchner K, Maasch C, Falke S, Rehders D, Klussmann S, Betzel C
Nat Commun. 2015 Apr 22;6:6923.
DOI: 10.1038/ncomms7923  |   PUBMED: 25901662   |   IF(2014) = 11.4
PDB [P13]:  4R8I   

75: Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry.
Zubriene A, Smirnoviene J, Smirnov A, Morkunaite V, Michailoviene V, Jachno J, Juozapaitiene V, Norvaisas P, Manakova E, Grazulis S, Matulis D
Biophys Chem. 2015 Oct;205:51-65.
DOI: 10.1016/J.BPC.2015.05.009  |   PUBMED: 26079542
PDB [P14]:  4WUP  4WR7  4WW8  4WW6  4WUQ   

74: Two independently folding units of Plasmodium profilin suggest evolution via genefusion.
Bhargav SP,Vahokoski J,Kallio JP,Torda AE,Kursula P,Kursula I
Cell Mol Life Sci. 2015 May 27.
DOI: 10.1007/s00018-015-1932-0  |   PUBMED: 26012696  |   IF(2018) = 7.0
PDB [P13]:  4D60   

73: 3-Sulfinopropionyl-coenzyme A (3SP-CoA) desulfinase from Advenellamimigardefordensis DPN7(T): crystal structure and function of a desulfinase with an acyl-CoA dehydrogenase fold.
Schurmann M, Meijers R, Schneider TR, Steinbuchel A, Cianci M
Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1360-72. Epub 2015 May 23.
DOI: 10.1107/S1399004715006616  |   PUBMED: 26057676  |   IF(2018) = 3.2
PDB [P13]:  5AF7  5AHS   

72: High resolution structures of Plasmodium falciparum GST complexes provide novelinsights into the dimer-tetramer transition and a novel ligand-binding site.
Perbandt M,Eberle R,Fischer-Riepe L,Cang H,Liebau E,Betzel C
J Struct Biol. 2015 Sep;191(3):365-75. Epub 2015 Jun 10.
DOI: 10.1016/J.JSB.2015.06.008  |   PUBMED: 26072058  |   IF(2018) = 3.8
PDB [P14]:  4ZXG   

71: Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Simdomain from the Hypoxia-inducible factor 3alpha.
Fala AM, Oliveira JF, Adamoski D, Aricetti JA, Dias MM, Dias MV, Sforca ML, Lopes-de-Oliveira PS, Rocco SA, Caldana C, Dias SM, Ambrosio AL
Sci Rep. 2015 Aug 3;5:12698.
DOI: 10.1038/SREP12698  |   PUBMED: 26237540  |   IF(2014) = 5.6
PDB [P13]:  4WN5   

70: Fragment Binding Can Be Either More Enthalpy-Driven or Entropy-Driven: CrystalStructures and Residual Hydration Patterns Suggest Why.
Ruhmann E, Betz M, Heine A, Klebe G
J Med Chem. 2015 Sep 10;58(17):6960-71. Epub2015 Aug 24.
DOI: 10.1021/ACS.JMEDCHEM.5B00812  |   PUBMED: 26270568  |   IF(2014) = 5.5
PDB [P14]:  4UDW  5AHG  5AF9  4UD9   

69: Functionalization of fluorinated benzenesulfonamides and their inhibitoryproperties toward carbonic anhydrases.
Dudutiene V, Zubriene A, Smirnov A, Timm DD, Smirnoviene J, Kazokaite J, Michailoviene V, Zaksauskas A, Manakova E, Grazulis S, Matulis D
ChemMedChem. 2015 Apr;10(4):662-87.
DOI: 10.1002/CMDC.201402490  |   PUBMED: 25758852  |   IF(2018) = 3.0
PDB [P13]:  4QIY  4QJ0  4QIZ  4QJP   

68: Structural basis of GD2 ganglioside and mimetic peptide recognition by 14G2aantibody.
Horwacik I, Golik P, Grudnik P, Kolinski M, Zdzalik M, Rokita H, Dubin G
Mol Cell Proteomics. 2015 Jul 15.
DOI: 10.1074/mcp.M115.052720  |   PUBMED: 26179345  |   IF(2018) = 4.8
PDB [P14]:  4TUK  4TUO  4TUL  4TRP   

67: Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanningprotein A (DisA) and its inhibition by 3'-dATP.
Muller M, Deimling T, Hopfner KP, Witte G
Biochem J. 2015 Aug 1;469(3):367-74. Epub 2015 May 27.
DOI: 10.1042/BJ20150373  |   PUBMED: 26014055
PDB [P14]:  4YVZ   

66: Natural flavonoids as antidiabetic agents. The binding of gallic and ellagicacids to glycogen phosphorylase b.
Kyriakis E, Stravodimos GA, Kantsadi AL, Chatzileontiadou DS, Skamnaki VT, Leonidas DD
FEBS Lett. 2015 Jul 8;589(15):1787-94. Epub2015 May 14.
DOI: 10.1016/j.febslet.2015.05.013  |   PUBMED: 25980608  |   IF(2018) = 2.7
PDB [P14]:  4Z5X   

65: Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly.
Male G, von Appen A, Glatt S, Taylor NM, Cristovao M, Groetsch H, Beck M, Muller CW
Nat Commun. 2015 Jun 10;6:7387.
DOI: 10.1038/NCOMMS8387  |   PUBMED: 26060179  |   IF(2014) = 11.4
PDB [P14]:  5AIO   

64: The crystal structure of Erwinia amylovora levansucrase provides a snapshot ofthe products of sucrose hydrolysis trapped into the active site.
Wuerges J, Caputi L, Cianci M, Boivin S, Meijers R, Benini S
J Struct Biol. 2015 Sep;191(3):290-8.
DOI: 10.1016/J.JSB.2015.07.010  |   PUBMED: 26208466  |   IF(2018) = 3.8
PDB [P13]:  4D47   

63: IGG FAB FRAGMENT CRYSTAL FORM 1/2
R.K.JENSEN, G.R.ANDERSEN
Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):419-26
DOI: 10.1107/S2053230X15004100  |   PUBMED: 25849503   |   IF(2019) = 0.97
PDB [P14]:  4X7T  4X7S   

62: A covalent homodimer probing early oligomers along amyloid aggregation.
Halabelian L, Relini A, Barbiroli A, Penco A, Bolognesi M, Ricagno S
Sci Rep. 2015 Sep 30;5:14651.
DOI: 10.1038/srep14651  |   PUBMED: 26420657  |   IF(2014) = 5.6
PDB [P14]:  4RA3   

61: Structural Elucidation of the Bispecificity of A Domains as a Basis forActivating Non-natural Amino Acids.
Kaljunen H, Schiefelbein SH, Stummer D, Kozak S, Meijers R, Christiansen G, Rentmeister A
Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8833-6.
DOI: 10.1002/ANGE.201503275  |   PUBMED: 26096082  |   IF(2014) = 11.6
PDB [P14]:  4D4I  4D4H  4D4G  4D56  4D57   

60: Tracing binding modes in hit-to-lead optimization: chameleon-like poses ofaspartic protease inhibitors.
Kuhnert M, Koster H, Bartholomaus R, Park AY, Shahim A, Heine A, Steuber H, Klebe G, Diederich WE
Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2849-53.
DOI: 10.1002/ANIE.201411206  |   PUBMED: 25630461  |   IF(2014) = 11.6
PDB [P14]:  3WZ6   

59: Structural Hot Spots Determine Functional Diversity of the Candida glabrataEpithelial Adhesin Family.
Diderrich R, Kock M, Maestre-Reyna M, Keller P, Steuber H, Rupp S, Essen LO, Mosch HU
J Biol Chem. 2015 Aug 7;290(32):19597-613.
DOI: 10.1074/jbc.M115.655654  |   PUBMED: 26105055  |   IF(2018) = 4.1
PDB [P14]:  4COZ  4COW   

58: Structure-Based Enzyme Tailoring of 5-Hydroxymethylfurfural Oxidase
Dijkman WP, Binda C, Fraaije MW, Mattevi A
ACS Catalysis. 5: 1833 (2015)
DOI: 10.1021/ACSCATAL.5B00031  |   PUBMED: NONE  |   IF(2018) = 12.1
PDB [P13]:  4UDP   

57: Thiosulfate dehydrogenase (TsdA) from Allochromatium vinosum: structural andfunctional insights into thiosulfate oxidation.
Brito JA, Denkmann K, Pereira IA, Archer M, Dahl C
J Biol Chem. 2015 Apr 3;290(14):9222-38.
DOI: 10.1074/JBC.M114.623397  |   PUBMED: 25673691   |   IF(2018) = 4.1
PDB [P14]:  4WQ8  4WQ9   

56: Structural and biochemical analysis of the essential diadenylate cyclase CdaAfrom Listeria monocytogenes.
Rosenberg J, Dickmanns A, Neumann P, Gunka K, Arens J, Kaever V, Stulke J, Ficner R, Commichau FM
J Biol Chem. 2015 Mar 6;290(10):6596-606.
DOI: 10.1074/jbc.M114.630418  |   PUBMED: 25605729  |   IF(2018) = 4.1
PDB [P13]:  4RV7   

55: Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2.
Glatt S, Zabel R, Vonkova I, Kumar A, Netz DJ, Pierik AJ, Rybin V, Lill R, Gavin AC, Balbach J, Breunig KD, Muller CW.
Structure. 2015 Jan 6;23(1):149-60
DOI: 10.1016/J.STR.2014.11.008  |   PUBMED: 25543256   |   IF(2014) = 6.8
PDB [P14]:  4D4O  4D4P   

54: Detailed structure-function correlations of Bacillus subtilis acetolactatesynthase.
Sommer B, von Moeller H, Haack M, Qoura F, Langner C, Bourenkov G, Garbe D, Loll B, Bruck T
ChemBioChem. 2015 Jan 2;16(1):110-8.
DOI: 10.1002/cbic.201402541  |   PUBMED: 25393087  |   IF(3.1) = 2.6
PDB [P14]:  4RJK   

Number of publications for 2015: 38

2014

53: Crystal structure of Bombyx mori lipoprotein 6: comparative structural analysis of the 30-kDa lipoprotein family
Pietrzyk AJ, Bujacz A, Lochynska M, Jaskolski M, Bujacz G
PLoS One. 2014 Nov 7;9(11):e108761
DOI: 10.1371/JOURNAL.PONE.0108761  |   PUBMED: 25379889   |   IF(2018) = 2.8
PDB [P14]:  4PC4   

52: Discovery and characterization of novel selective inhibitors of carbonicanhydrase IX.
Dudutiene V, Matuliene J, Smirnov A, Timm DD, Zubriene A, Baranauskiene L, Morkunaite V, Smirnoviene J, Michailoviene V, Juozapaitiene V, Mickeviciute A, Kazokaite J, Baksyte S, Kasiliauskaite A, Jachno J, Revuckiene J, Kisonaite M, Pilipuityte V, Ivanauskaite E, Milinaviciute G, Smirnovas V, Petrikaite V, Kairys V, Petrauskas V, Norvaisas P, Linge D, Gibieza P, Capkauskaite E, Zaksauskas A, Kazlauskas E, Manakova E, Grazulis S, Ladbury JE, Matulis D
J Med Chem. 2014 Nov 26;57(22):9435-46.
DOI: 10.1021/JM501003K  |   PUBMED: 25358084   |   IF(2014) = 5.4
PDB [P13]:  4Q07  4PZH  4Q06  4Q09  4Q08   

51: Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Tamulaitiene G, Silanskas A, Grazulis S, Zaremba M, Siksnys V.
Nucleic Acids Res. 2014 Dec 16;42(22):14022-30.
DOI: 10.1093/NAR/GKU1237  |   PUBMED: 25429979   |   IF(2018) = 11.1
PDB [P13]:  4RD5   

50: Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin.
Grudnik P, Debowski D, Legowska A, Malicki S, Golik P, Karna N, Rolka K, Dubin G.
Proteins. 2014 Dec 24.
DOI: 10.1002/PROT.24750  |   PUBMED: 25546528   |   IF(2014) = 2.9
PDB [P13]:  4U2W   

49: 4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.
Rutkauskas K, Zubriene A, Tumosiene I, Kantminiene K, Kazemekaite M, Smirnov A, Kazokaite J, Morkunaite V, Capkauskaite E, Manakova E, Grazulis S, Beresnevicius ZJ, Matulis D
Molecules (2014) 19: 17356-17380
DOI: 10.3390/MOLECULES191117356  |   PUBMED: 25353386   |   IF(2020) = 3.3
PDB [P13]:  4Q6E  4Q6D   

48: Schulz EC, Barabas O
Structure of an Escherichia coli Hfq:RNA complex at 0.97 A resolution.
Acta Crystallogr Sect F. (2014) 70: 1492-1497
DOI: 10.1107/S2053230X14020044  |   PUBMED: 25372815   |   IF(2019) = 0.97
PDB [P13]:  4PNO   

47: Das, U., Pogenberg, V., Tiruttani Subhramanyam, U.K., Wilmanns, M., Gourinath, S., Srinivasan, A.
Crystal Structure of the Vapbc-15 Complex from Mycobacterium Tuberculosis Reveals a Two-Metal Ion Dependent Pin-Domain Ribonuclease And a Variable Mode of Toxin-Antitoxin Assembly
J Struct Biol. (2014) 188:249-258
DOI: 10.1016/J.JSB.2014.10.002  |   PUBMED: 25450593  |   IF(2014) = 3.4
PDB [P13]:  4CHG   

46: Crystal structure of the rigor-like human non-muscle myosin-2 motor domain.
Munnich S,Pathan-Chhatbar S,Manstein DJ
FEBS Lett. 2014 Dec 20;588(24):4754-60.
DOI: 10.1016/j.febslet.2014.11.007  |   PUBMED: 25451231  |   IF(2018) = 2.7
PDB [P14]:  4PD3   

45: Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress.
Chaves-Sanjuan A, Sanchez-Barrena MJ, Gonzalez-Rubio JM, Moreno M, Ragel P, Jimenez M, Pardo JM, Martinez-Ripoll M, Quintero FJ, Albert A.
Proc Natl Acad Sci U S A. (2014) Oct 6.
DOI: 10.1073/PNAS.1407610111  |   PUBMED: 25288725   |   IF(2014) = 9.6
PDB [P13]:  4D28   

44: Sainz-Polo MA, Valenzuela SV, Gonzále B, Pastor F2, Sanz-Aparicio J.
Structural analysis of glucuronoxylan specific Xyn30D and its attached CBM35 domain give insights into the role of modularity in specificity
J Biol Chem. 2014 Sep 8.
DOI: 10.1074/JBC.M114.597732  |   PUBMED: 25202007   |   IF(2018) = 4.1
PDB [P13]:  4QB2   

43: Kuhle B, Ficner R.
A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
EMBO J. 2014 Sep 15.
DOI: 10.15252/EMBJ.201488517  |   PUBMED: 25225612   |   IF(2013) = 10.7
PDB [P13]:  4TMV   

42: Liu Y, Neumann P, Kuhle B, Monecke T, Schell S, Chari A, Ficner R.
Translation initiation factor eIF3b contains a nine-bladed β-propeller and interacts with the 40S ribosomal subunit.
Structure. 2014 Jun 10;22(6):923-30
DOI: 10.1016/J.STR.2014.03.010  |   PUBMED: 24768115   |   IF(2013) = 5.3
PDB [P13]:  4NOX   

41: Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HD, Svergun DI, Zhang Y, Wang JH, Meijers R.
The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue.
Neuron. 2014 Aug 20;83(4):839-49
DOI: 10.1016/J.NEURON.2014.07.010  |   PUBMED: 25123307   |   IF(2013) = 16.5
PDB [P14]:  4URT   

40: Benini S, Cianci M, Mazzei L, Ciurli S.
Fluoride inhibition of Sporosarcina pasteurii urease: structure and thermodynamics.
J Biol Inorg Chem. 2014 epub
DOI: 10.1007/S00775-014-1182-X  |   PUBMED: 25113581   |   IF(2018) = 3.6
PDB [P13]:  4CEU  4CEX   

39: Salamun J, Kallio JP, Daher W, Soldati-Favre D, Kursula I.
Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress.
FASEB J. 2014 Aug 11.
DOI: 10.1096/fj.14-252569  |   PUBMED: 25114175
PDB [P14]:  4OZU   

38: Prokofev, I.I., Lashkov, A.A., Gabdoulkhakov, A.G., Dontsova, M.V., Seregina, T.A., Mironov, A.S., Betzel, C., Mikhailov, A.M.
Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil
Acta Crystallogr Sect F. 70: 60-63 (2014)
DOI: 10.1107/S2053230X13031877  |   PUBMED: 24419619  |   IF(2019) = 0.97
PDB [P13]:  4K6O   

37: Dunne M, Mertens HD, Garefalaki V, Jeffries CM, Thompson A, Lemke EA, Svergun DI, Mayer MJ, Narbad A, Meijers R.
The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor.
PLoS Pathog. 2014 Jul 24;10(7):e1004228.
DOI: 10.1371/journal.ppat.1004228  |   PUBMED: 25058163   |   IF(2013) = 8.7
PDB [P14]:  4CU2   

36: Sauter, A., Oelker, M., Zocher, G., Zhang, F., Stehle, T., Schreiber, F.
Non-Classical Pathways of Protein Crystallization in the Presence of Multivalent Metal Ions
Cryst Growth Des. 2014, 14, 12, 6357-6366
DOI: 10.1021/cg501099d  |   PUBMED:
PDB [P13]:  4LZV   

35: Wen Y, Behiels E, Felix J, Elegheert J, Vergauwen B, Devreese B, Savvides SN.
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res. 2014 Nov 1;42(15):10134-47
DOI: 10.1093/nar/gku665  |   PUBMED: 25056321   |   IF(2018) = 11.1
PDB [P13]:  4PU4  4PU5  4PU7  4PU8   

34: Specific binding of gibberellic acid by Cytokinin-Specific Binding Proteins: a new aspect of plant hormone-binding proteins with the PR-10 fold.
Ruszkowski M, Sliwiak J, Ciesielska A, Barciszewski J, Sikorski M, Jaskolski M.
Acta Crystallogr Sect D. 70: 2032-2041 (2014)
DOI: 10.1107/S1399004714010578  |   PUBMED: 25004979   |   IF(2018) = 3.2
PDB [P14]:  4PSB   

33: Chasing Protons: How Isothermal Titration Calorimetry, Mutagenesis, and pKa Calculations Trace the Locus of Charge in Ligand Binding to a tRNA-Binding Enzyme.
Neeb M1, Czodrowski P, Heine A, Barandun LJ, Hohn C, Diederich F, Klebe G.
J Med Chem. 2014 Jul 10;57(13):5554-65.
DOI: 10.1021/jm500401x  |   PUBMED: 24955548   |   IF(2018) = 6.1
PDB [P14]:  4PUN  4PUM  4PUL   

32: Kuhle, B., Ficner, R.
eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
EMBO J. 33:1177-91 (2014).
DOI: 10.1002/embj.201387344  |   PUBMED: 24686316   |   IF(2018) = 11.2
PDB [P13]:  4N3N  4N3G  4NCL  4N3S  4NCF   

31: Bjerregaard-Andersen, K., Sommer, T., Jensen, J.K., Jochimsen, B., Etzerodt, M., Morth, J.P.
A proton wire and water channel revealed in the crystal structure of isatin hydrolase
J Biol Chem. 2014 Jun 10.
DOI: 10.1074/jbc.M114.568824  |   PUBMED: 24917679   |   IF(2018) = 4.1
PDB [P13]:  4M8D   

30: Janke, R., Goerner, C., Hirte, M., Brueck, T., Loll, B
The first structure of a bacterial diterpene cyclase: CotB2
Acta Crystallogr Sect D. D70 (2014)
DOI: 10.1107/S1399004714005513  |   PUBMED: 24914964  |   IF(2018) = 3.2
PDB [P14]:  4OMH  4OMG   

29: Mierzejewska, K., Siwek, W., Czapinska, H., Skowronek, K., Bujnicki, J.M., Bochtler, M.
Structural basis of the methylation specificity of R.DpnI.
Nucleic Acids Res. 42: 8745-8754 (2014)
DOI: 10.1093/nar/gku546  |   PUBMED: 24966351  |   IF(2018) = 11.1
PDB [P14]:  4KYW   

28: Espina, G., Eley, K., Pompidor, G., Schneider, T.R., Crennell, S.J., Danson, M.J.
A novel β-xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds.
Acta Crystallogr Sect D. 70: 1366 (2014)
DOI: 10.1107/S1399004714002788  |   PUBMED: 24816105  |   IF(2018) = 3.2
PDB [P13]:  4C1O   

27: Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping.
Han H, Kursula P.
J Biol Chem (2014 May)289:14121-14131
DOI: 10.1074/jbc.M114.554816  |   PUBMED: 24675079  |   IF(2018) = 4.1
PDB [P13]:  4CMZ  4CN0   

26: Kazrani, A.A., Kowalska, M., Czapinska, H., Bochtler, M.
Crystal structure of the 5hmC specific endonuclease PvuRts1I
Nucleic Acids Res. 2014 Mar 25. [Epub ahead of print]
DOI: 10.1093/nar/gku186  |   PUBMED: 24634440  |   IF(2018) = 11.1
PDB [P13]:  4OQ2   

25: Structural basis of the proinflammatory signaling complex mediated by TSLP
Verstraete, K, van Schie, L, Vyncke, L, Bloch, Y, Tavernier, J, Pauwels, E, Peelman, F, Savvides, SN
Nat Struct Mol Biol. 2014 Apr;21(4):375-82.
DOI: 10.1038/nsmb.2794  |   PUBMED: 24632570  |   IF(2013) = 11.6
PDB [P13]:  4NN5  4NN6  4NN7   

24: Crystal structures of two tetrameric β-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora.
Lehneck R, Neumann P, Vullo D, Elleuche S, Supuran CT, Ficner R, Pöggeler S.
FEBS J. 2014 Apr;281(7):1759-72.
DOI: 10.1111/febs.12738  |   PUBMED: 24506675  |   IF(2018) = 4.7
PDB [P13]:  4O1K   

23: Role of kappa -> lambda light-chain constant-domain switch in the structure and functionality of A17 reactibody
N. Ponomarenko, S. D. Chatziefthimiou, I. Kurkova, Yu. Mokrushina, Y. Mokrushina, A. Stepanova, I. Smirnov, M. Avakyan, T. Bobik, A. Mamedov, V. Mitkevich, A. Belogurov Jr, O. S. Fedorova, M. Dubina, A. Golovin, V. Lamzin, A. Friboulet, A. A. Makarov, M. Wilmanns and A. Gabibov
Acta Crystallogr D Biol Crystallogr. (2014) D70:708-719
DOI: 10.1107/S1399004713032446  |   PUBMED: 24598740  |   IF(2018) = 3.2
PDB [P14]:  3ZL4   

22: Structural Basis for Binding of Fluorinated Glucose and Galactose to Trametes multicolor Pyranose 2-Oxidase Variants with Improved Galactose Conversion
Tan TC, Spadiut O, Gandini R, Haltrich D, Divne C.
PLoS One. 2014; 9(1): e86736
DOI: 10.1371/journal.pone.0086736  |   PUBMED: 24466218  |   IF(2018) = 2.8
PDB [P13]:  4MOG  4MOI  4MOR   

21: Serial crystallography on in vivo-grown microcrystals using synchrotron radiation
Gati, C., Bourenkov, G., Klinge, M., Rehders, D., Stellato, F., Oberthuer, D., Yefanov, O., Sommer, B.P., Mogk, S., Duszenko, M. et al. (2014).
IUCrJ. (2014) 1 87-94
DOI: 10.1107/S2052252513033939  |   PUBMED: 25075324   |   IF(2020) = 4
PDB [P14]:  4N4Z   

20: Resolving the activation site of positive regulators in plant phosphoenolpyruvate carboxylase.
Schlieper D, Förster, K, Paulus JK, Groth G
Mol Plant. 7:437-40 (2014)
DOI: 10.1093/mp/sst130  |   PUBMED: 24043710  |   IF(2019) = 10.8
PDB [P14]:  4BXC   

Number of publications for 2014: 34

2013

19: CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis.
Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T.
Cell. 155:647 (2013).
DOI: 10.1016/j.cell.2013.09.050  |   PUBMED: 24243021  |   IF(2018) = 36.2
PDB [P14]:  4C2G   

18: Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII
Capkauskaite E, Zubriene A, Smirnov A, Torresan J, Kišonaie M, Kazokaite J, Gylyte J, Michailoviene V, Jogaite V, Manakova E, Gražulis S, Tumkevcius S, Matulis D.
Bioorg Med Chem. 21:6937-6947 (2013)
DOI: 10.1016/j.bmc.2013.09.029  |   PUBMED: 24103428  |   IF(2018) = 2.5
PDB [P14]:  4KNN  4KP5   

17: The landscape of cytokinin binding by a plant nodulin.
Ruszkowski M, Szpotkowski K, Sikorski M, Jaskolski M.
Acta Crystallogr D Biol Crystallogr. (2013) 69:2365-80
DOI: 10.1107/S0907444913021975  |   PUBMED: 24311578   |   IF(2018) = 3.2
PDB [P14]:  4GY9   

16: Crystal structure of the 14-subunit RNA polymerase I
Fernandez-Tornero C, Moreno-Morcillo M, Rashid UJ, Taylor NM, Ruiz FM, Gruene T, Legrand P, Steuerwald U, Mueller CW.
Nature. 502:644 (2013)
DOI: 10.1038/nature12636  |   PUBMED: 24153184  |   IF(2018) = 43.1
PDB [P14]:  4C3I   

15: Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency
Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE.
PLoS Pathog. 9(10):e1003673 (2013)
DOI: 10.1371/journal.ppat.1003673  |   PUBMED: 24146618  |   IF(2018) = 6.1
PDB [P14]:  4BLG   

14: Iron Binding at Specific Sites within the Octameric HbpS Protects Streptomycetes from Iron-Mediated Oxidative Stress.
Wedderhoff I, Kursula I, Groves MR, Ortiz de Orué Lucana .
PLoS One. 2013 Aug 27;8(8):e71579.
DOI: 10.1371/journal.pone.0071579  |   PUBMED: 24013686  |   IF(2018) = 2.8
PDB [P13]:  4BMW   

13: Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus.
Coronado MA, Gabdulkhakov A, Georgieva D, Sankaran B, Murakami MT, Arni RK, Betzel C.
Acta Crystallogr D Biol Crystallogr. D69:1958-64 (2013)
DOI: 10.1107/S0907444913018003  |   PUBMED: 24100315  |   IF(2018) = 3.2
PDB [P14]:  4GV5   

12: Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
Punekar AS, Liljeruhm J, Shepherd TR, Forster AC, Selmer M.
Nucleic Acids Res. 41(20):9537-48 (2013)
DOI: 10.1093/nar/gkt719  |   PUBMED: 23945937  |   IF(2018) = 11.1
PDB [P13]:  4BLW   

11: Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.
Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA.
Nucleic Acids Res. 2013 41(11):5912
DOI: 10.1093/nar/gkt268  |   PUBMED: 23595147  |   IF(2018) = 11.1
PDB [P14]:  3ZLA   

10: The hepatitis B virus preS1 domain hijacks host trafficking proteins by motif mimicry.
Jürgens MC, Vürüs J, Rautureau GJ, Shepherd DA, Pye VE, Muldoon J, Johnson CM, Ashcroft AE, Freund SM, Ferguson N.
Nat Chem Biol. 2013 Sep;9(9):540-7.
DOI: 10.1038/nchembio.1294.  |   PUBMED: 23851574  |   IF(2013) = 13.2
PDB [P14]:  3ZHF   

9: Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family
Myllykoski M, Raasakka A, Lehtimäki M, Han H, Kursula I, Kursula P.
J Mol Biol. 425:4307-22 (2013)
DOI: 10.1016/j.jmb.2013.06.012  |   PUBMED: 23831225  |   IF(2018) = 5.1
PDB [P14]:  2YPC   

8: Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann C C, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner K P
Nature. 2013 498:332-337
DOI: 10.1038/nature12305  |   PUBMED: 23722159  |   IF(2014) = 41.4
PDB [P14]:  4KB6   

7: Cloning, expression, purification, crystallization and preliminary X-ray analysis of EaLsc, a levansucrase from Erwinia amylovora
Caputi L, Cianci M, Benini S
Acta Crystallogr F Struct Biol Commun. F69:570-573 (2013)
DOI: 10.1107/S1744309113010750  |   PUBMED: 23695580  |   IF(2019) = 0.97
PDB [P13]:   

6: Greater efficiency of photosynthetic carbon fixation due to single amino-acid substitution.
Paulus JK, Schlieper D, Groth G.
Nat Commun. 4:1518 (2013)
DOI: 10.1038/ncomms2504  |   PUBMED: 23443546  |   IF(2013) = 10.2
PDB [P14]:  3ZGB   

5: The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design
Benini S, Kosikowska P, Cianci M, Mazzei L, Vara AG, Berlicki , Ciurli S
J Biol Inorg Chem. 2013 Mar;18(3):391-9.
DOI: 10.1007/s00775-013-0983-7  |   PUBMED: 23412551  |   IF(2018) = 3.6
PDB [P14]:  4AC7   

4: A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.
Malvezzi F, Litos G, Schleiffer A, Heuck A, Mechtler K, Clausen T, Westermann S.
EMBO J. 2013 Feb 6;32(3):409-23.
DOI: 10.1038/emboj.2012.356  |   PUBMED: 23334295  |   IF(2018) = 11.2
PDB [P14]:  4GEQ   

Number of publications for 2013: 16

2012

3: Structural basis for cooperativity of CRM1 export complex formation.
Monecke T, Haselbach D, VoßB, Russek A, Neumann P, Thomson E, Hurt E, Zachariae U, Stark H, Grubmüller H, Dickmanns A, Ficner R.
Proc Natl Acad Sci U S A. 2012 Dec 31. [Epub ahead of print]
DOI: 10.1073/pnas.1215214110  |   PUBMED: 23277578  |   IF(2019) = 9.4
PDB [P14]:  4HZK   

2: Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Santos KF, Jovin SM, Weber G, Pena V, Lührmann R, Wahl MC
Proc Natl Acad Sci U S A. (2012) Oct 23;109(43):17418-23. Epub 2012 Oct 8.
DOI: 10.1073/nas.1208098109  |   PUBMED: 23045696  |   IF(2019) = 9.4
PDB [P14]:  4F91   

Number of publications for 2012: 2

2008

1: Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.
Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slättegård R, Hernalsteens JP, Wyns L, Oscarson S, De Greve H, Hultgren S, Bouckaert J.
PLoS One (2008 Apr)3:e2040
DOI: 10.1371/journal.pone.0002040  |   PUBMED: 18446213  |   IF(2018) = 2.8
PDB [P14]:  7QUO