585: The effects of nature-inspired amino acid substitutions on structural and biochemical properties of the E. coli L-asparaginase EcAIII.
Janicki M, Ściuk A, Zielezinski A, Ruszkowski M, Ludwików A, Karlowski WM, Jaskolski M, Loch JI.
Protein Sci (2023 Apr)UNK:e4647
DOI: 10.1002/pro.4647 |
PUBMED: 37095066 | IF(2018) = 2.4
PDB [P13]: 8BKF 8C23 8BI3
584: Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b.
Kaspers MS, Pogenberg V, Pett C, Ernst S, Ecker F, Ochtrop P, Groll M, Hedberg C, Itzen A.
Nat Commun (2023 Apr)14:2245
DOI: 10.1038/s41467-023-37621-7 |
PUBMED: 37076474 | IF(2022) = 14.9
PDB [P13]: 8AGG 8ALK
583: Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability.
Sutinen A, Paffenholz D, Nguyen GTT, Ruskamo S, Torda AE, Kursula P.
PLoS One (2023 )18:e0284532
DOI: 10.1371/journal.pone.0284532 |
PUBMED: 37058526 | IF(2018) = 2.8
PDB [P13]: 8A4J
582: Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction.
Chan DCK, Josts I, Koteva K, Wright GD, Tidow H, Burrows LL.
Proc Natl Acad Sci U S A (2023 Apr)120:e2221253120
DOI: 10.1073/pnas.2221253120 |
PUBMED: 37043535 | IF(2019) = 9.4
PDB [P13]: 8B43
581: Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Tsirigotaki A, Dansercoer A, Verschueren KHG, Marković I, Pollmann C, Hafer M, Felix J, Birck C, Van Putte W, Catteeuw D, Tavernier J, Fernando Bazan J, Piehler J, Savvides SN, Verstraete K.
Nat Struct Mol Biol. (2023 Mar)UNK:pp. UNK
DOI: 10.1038/s41594-023-00941-9 |
PUBMED: 36959263 | IF(2019) = 11.7
PDB [P13]: 8AV2 7Z3Q 7Z3R
580: Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and Sulfoxidations.
Kratky J, Eggerichs D, Heine T, Hofmann S, Sowa P, Weiße RH, Tischler D, Sträter N.
Angew Chem Int Ed Engl (2023 Apr)62:e202300657
DOI: 10.1002/anie.202300657 |
PUBMED: 36762980 | IF(2019) = 13.0
PDB [P14]: 7Z97
579: Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6).
Rutkiewicz M, Nogues I, Witek W, Angelaccio S, Contestabile R, Ruszkowski M.
Plant Physiol Biochem (2023 Mar)196:759-773
DOI: 10.1016/j.plaphy.2023.02.017 |
PUBMED: 36842242 | IF(2019) = 3.72
PDB [P13]: 8BJ4
578: Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.
Soni K, Sivadas A, Horvath A, Dobrev N, Hayashi R, Kiss L, Simon B, Wild K, Sinning I, Fischer T.
Nat Commun. (2023 Feb)14:772
DOI: 10.1038/s41467-023-36402-6 |
PUBMED: 36774373 | IF(2022) = 14.9
PDB [P13P14]: 7Q74 7Q72 7Q73
577: Cytidine deaminases catalyze the conversion of N(S,O)4-substituted pyrimidine nucleosides.
Urbelienė N, Tiškus M, Tamulaitienė G, Gasparavičiūtė R, Lapinskaitė R, Jauniškis V, Sūdžius J, Meškienė R, Tauraitė D, Skrodenytė E, Urbelis G, Vaitekūnas J, Meškys R.
Sci Adv (2023 Feb)9:eade4361
DOI: 10.1126/sciadv.ade4361 |
PUBMED: 36735785 | IF(2018) = 12.5
PDB [P13]: 7ZOB
576: Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria.
Shuoker B, Pichler MJ, Jin C, Sakanaka H, Wu H, Gascueña AM, Liu J, Nielsen TS, Holgersson J, Nordberg Karlsson E, Juge N, Meier S, Morth JP, Karlsson NG, Abou Hachem M.
Nat Commun (2023 Apr)14:1833
DOI: 10.1038/s41467-023-37533-6 |
PUBMED: 37005422 | IF(2022) = 14.9
PDB [P14]: 8AXT 8AYR
575: Does the presence of ground state complex between a PR-10 protein and a sensitizer affect the mechanism of sensitized photo-oxidation?
Ignasiak-Kciuk M, Nowicka-Bauer K, Grzechowiak M, Ravnsborg T, Frąckowiak K, Jensen ON, Jaskólski M, Marciniak B.
Free Radic Biol Med (2023 Mar)198:27-43
DOI: 10.1016/j.freeradbiomed.2023.01.022 |
PUBMED: 36738800
PDB [P14]: 7QB6
574: Structural basis of the activation of PPARγ by the plasticizer metabolites MEHP and MINCH.
Useini A, Engelberger F, Künze G, Sträter N.
Environ Int (2023 Mar)173:107822
DOI: 10.1016/j.envint.2023.107822 |
PUBMED: 36841188
PDB [P13]: 8BF1
573: X-ray structure and function of fibronectin domains two and three of the neural cell adhesion molecule L1.
Guédez G, Loers G, Jeffries CM, Kozak S, Meijers R, Svergun DI, Schachner M, Löw C.
FASEB J (2023 Mar)37:e22823
DOI: 10.1096/fj.202201511r |
PUBMED: 36809668
PDB [P13]: 8AFP 8AFO
572: Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.
Talaj JA, Zielinski K, Bujacz A.
Int J Mol Sci (2023 Jan)24:1534
DOI: 10.3390/ijms24021534 |
PUBMED: 36675044 | IF(2018) = 4.2
PDB [P14]: 6HN0
571: MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus.
Shearer HL, Loi VV, Weiland P, Bange G, Altegoer F, Hampton MB, Antelmann H, Dickerhof N.
Mol Microbiol (2023 Apr)119:456-470
DOI: 10.1111/mmi.15035 |
PUBMED: 36779383 | IF(2018) = 3.6
PDB [P13]: 8AJK 8AJJ
570: Parameterization of a single H-bond in Orange Carotenoid Protein by atomic mutation reveals principles of evolutionary design of complex chemical photosystems.
Moldenhauer M, Tseng HW, Kraskov A, Tavraz NN, Yaroshevich IA, Hildebrandt P, Sluchanko NN, Hochberg GA, Essen LO, Budisa N, Korf L, Maksimov EG, Friedrich T.
Front Mol Biosci (2023 )10:1072606
DOI: 10.3389/fmolb.2023.1072606 |
PUBMED: 36776742 | IF(2022) = 4.6
PDB [P14]: 7ZXV
569: Fortuitously compatible protein surfaces primed allosteric control in cyanobacterial photoprotection.
Steube N, Moldenhauer M, Weiland P, Saman D, Kilb A, Ramírez Rojas AA, Garg SG, Schindler D, Graumann PL, Benesch JLP, Bange G, Friedrich T, Hochberg GKA.
Nat Ecol Evol (2023 Apr)UNK:pp. UNK
DOI: 10.1038/s41559-023-02018-8 |
PUBMED: 37012377
PDB [P13]: 8AG8
568: Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein.
Hollmann NM, Jagtap PKA, Linse JB, Ullmann P, Payr M, Murciano B, Simon B, Hub JS, Hennig J.
Nucleic Acids Res (2023 Feb)51:1895-1913
DOI: 10.1093/nar/gkac1277 |
PUBMED: 36688322 | IF(2018) = 11.1
PDB [P13]: 7ZHH
567: Improved cytosine base editors generated from TadA variants.
Lam DK, Feliciano PR, Arif A, Bohnuud T, Fernandez TP, Gehrke JM, Grayson P, Lee KD, Ortega MA, Sawyer C, Schwaegerle ND, Peraro L, Young L, Lee SJ, Ciaramella G, Gaudelli NM.
Nat Biotechnol. (2023 Jan)UNK:pp. UNK
DOI: 10.1038/s41587-022-01611-9 |
PUBMED: 36624149
PDB [P13]: 8E2S
566: Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
Rotheneder M, Stakyte K, van de Logt E, Bartho JD, Lammens K, Fan Y, Alt A, Kessler B, Jung C, Roos WP, Steigenberger B, Hopfner KP.
Mol Cell. (2023 Jan)83:167-185.e9
DOI: 10.1016/j.molcel.2022.12.003 |
PUBMED: 36577401 | IF(2018) = 14.5
PDB [P14]: 7ZQY
565: Linking medicinal cannabis to autotaxin-lysophosphatidic acid signaling.
Eymery MC, McCarthy AA, Hausmann J.
Life Sci Alliance (2023 Feb)6:e202201595
DOI: 10.26508/lsa.202201595 |
PUBMED: 36623871
PDB [P13P14]: 7P4O 7P4J
564: Right-handed Z-DNA at ultrahigh resolution: a tale of two hands and the power of the crystallographic method.
Drozdzal P, Manszewski T, Gilski M, Brzezinski K, Jaskolski M.
Acta Crystallogr D Struct Biol (2023 Feb)79:133-139
DOI: 10.1107/s2059798322011937 |
PUBMED: 36762859 | IF(2018) = 3.2
PDB [P13]: 8A71
563: Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase.
Bürgi J, Lill P, Giannopoulou EA, Jeffries CM, Chojnowski G, Raunser S, Gatsogiannis C, Wilmanns M.
Biol Chem. (2023 Feb)404:195-207
DOI: 10.1515/hsz-2022-0273 |
PUBMED: 36694962
PDB [P13]: 8AFG
562: Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors.
Krammer EM, Bridot C, Serna S, Echeverria B, Semwal S, Roubinet B, van Noort K, Wilbers RP, Bourenkov G, de Ruyck J, Landemarre L, Reichardt N, Bouckaert J.
J Biol Chem (2023 Mar)UNK:104627
DOI: 10.1016/j.jbc.2023.104627 |
PUBMED: 36944399 | IF(2018) = 4.1
PDB [P14]: 8BY3
561: A Key Role in Catalysis and Enzyme Thermostability of a Conserved Helix H5 Motif of Human Glutathione Transferase A1-1.
Chronopoulou EG, Mutabdzija L, Poudel N, Papageorgiou AC, Labrou NE.
Int J Mol Sci (2023 Feb)24:3700
DOI: 10.3390/ijms24043700 |
PUBMED: 36835112 | IF(2018) = 4.2
PDB [P13]: 8BHE 8BHC
560: Structural Basis for a Cork-Up Mechanism of the Intra-Molecular Mesaconyl-CoA Transferase.
Pfister P, Zarzycki J, Erb TJ.
Biochemistry. (2023 Jan)62:75-84
DOI: 10.1021/acs.biochem.2c00532 |
PUBMED: 36535006 | IF(2018) = 3.0
PDB [P14]: 8APQ
559: Structural insights into the function-modulating effects of nanobody binding to the integrin receptor αMβ2.
Jensen RK, Pedersen H, Lorentzen J, Laursen NS, Vorup-Jensen T, Andersen GR.
J Biol Chem (2022 Aug)298:102168
DOI: 10.1016/j.jbc.2022.102168 |
PUBMED: 35738398 | IF(2018) = 4.1
PDB [P14]: 7NP9
558: The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Brinkhaus M, Pannecoucke E, van der Kooi EJ, Bentlage AEH, Derksen NIL, Andries J, Balbino B, Sips M, Ulrichts P, Verheesen P, de Haard H, Rispens T, Savvides SN, Vidarsson G.
Nat Commun (2022 Oct)13:6073
DOI: 10.1038/s41467-022-33764-1 |
PUBMED: 36241613 | IF(2022) = 14.9
PDB [P14]: 7Q3P
557: A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins.
Erven I, Abraham E, Hermanns T, Baumann U, Hofmann K.
Nat Commun (2022 Dec)13:7643
DOI: 10.1038/s41467-022-35244-y |
PUBMED: 36496440 | IF(2022) = 14.9
PDB [P13]: 8ADD 8ADB 8ADC
556: Antiviral signaling by a cyclic nucleotide activated CRISPR protease.
Rouillon C, Schneberger N, Chi H, Blumenstock K, Da Vela S, Ackermann K, Moecking J, Peter MF, Boenigk W, Seifert R, Bode BE, Schmid-Burgk JL, Svergun D, Geyer M, White MF, Hagelueken G.
Nature (2022 Nov)UNK:pp. UNK
DOI: 10.1038/s41586-022-05571-7 |
PUBMED: 36423657
PDB [P13]: 8B0U 8B0R 7QDA
555: Structural, Thermodynamic and Enzymatic Characterization of N,N-Diacetylchitobiose Deacetylase from Pyrococcus chitonophagus.
Biniek-Antosiak K, Bejger M, Śliwiak J, Baranowski D, Mohammed ASA, Svergun DI, Rypniewski W.
Int J Mol Sci (2022 Dec)23:15736
DOI: 10.3390/ijms232415736 |
PUBMED: 36555375 | IF(2018) = 4.2
PDB [P13]: 8BGO 8BGP 8BGN
554: Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Orsi DL, Ferrara SJ, Siegel S, Friberg A, Bouché L, Pook E, Lienau P, Bluck JP, Lemke CT, Akcay G, Stellfeld T, Meyer H, Pütter V, Holton SJ, Korr D, Jerchel-Furau I, Pantelidou C, Strathdee CA, Meyerson M, Eis K, Goldstein JT.
Bioorg Med Chem (2022 Dec)78:117130
DOI: 10.1016/j.bmc.2022.117130 |
PUBMED: 36542958 | IF(2018) = 2.5
PDB [P14]: 8B94 8B95 8B8Y
553: Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis.
Minazzato G, Gasparrini M, Heroux A, Sernova NV, Rodionov DA, Cianci M, Sorci L, Raffaelli N.
J Struct Biol (2022 Dec)214:107917
DOI: 10.1016/j.jsb.2022.107917 |
PUBMED: 36332744 | IF(2018) = 3.8
PDB [P13]: 7Q93 7Q94
552: A MademoiseLLE domain binding platform links the key RNA transporter to endosomes.
Devan SK, Schott-Verdugo S, Müntjes K, Bismar L, Reiners J, Hachani E, Schmitt L, Höppner A, Smits SH, Gohlke H, Feldbrügge M.
PLoS Genet (2022 Jun)18:e1010269
DOI: 10.1371/journal.pgen.1010269 |
PUBMED: 35727840
PDB [P14]: 7PZE
551: Cyanide Binding to [FeFe]-Hydrogenase Stabilizes the Alternative Configuration of the Proton Transfer Pathway.
Duan J, Hemschemeier A, Burr DJ, Stripp ST, Hofmann E, Happe T.
Angew Chem Int Ed Engl. (2022 Dec)UNK:pp. UNK
DOI: 10.1002/anie.202216903 |
PUBMED: 36464641 | IF(2019) = 13.0
PDB [P13P14]: 8ALN 8AP2
550: Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans
Hassani Nia F, Woike D, Bento I, Niebling S, Tibbe D, Schulz K, Hirnet D, Skiba M, Hönck HH, Veith K, Günther C, Scholz T, Bierhals T, Driemeyer J, Bend R, Failla AV, Lohr C, Alai MG, Kreienkamp HJ.
Mol Psychiatry. (2022 Nov)UNK:pp. UNK
DOI: 10.1038/s41380-022-01882-3 |
PUBMED: 36450866 | IF(2022) = 16.0
PDB [P14]: 8ATJ 8B10
549: Characterization of a glycoside hydrolase endolysin from Acinetobacter baumannii phage AbTZA1 with high antibacterial potency and novel structural features.
Premetis GE, Stathi A, Papageorgiou AC, Labrou NE.
FEBS J. (2022 Nov)UNK:pp. UNK
DOI: 10.1111/febs.16686 |
PUBMED: 36413083 | IF(2018) = 4.7
PDB [P13]: 8APP
548: Disarming of type I-F CRISPR-Cas surveillance complex by anti-CRISPR proteins AcrIF6 and AcrIF9.
Kupcinskaite E, Tutkus M, Kopūstas A, Ašmontas S, Jankunec M, Zaremba M, Tamulaitiene G, Sinkunas T.
Sci Rep. (2022 Sep)12:15548
DOI: 10.1038/s41598-022-19797-y |
PUBMED: 36109551 | IF(2022) = 5.0
PDB [P13]: 7BB5
547: The Na+,K+-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state.
Fruergaard MU, Dach I, Andersen JL, Ozol M, Shahsavar A, Quistgaard EM, Poulsen H, Fedosova NU, Nissen P.
J Biol Chem (2022 Sep)298:102317
DOI: 10.1016/j.jbc.2022.102317 |
PUBMED: 35926706 | IF(2018) = 4.1
PDB [P13P14]: 7QTV
546: The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach.
Shao J, Kuiper BP, Thunnissen AWH, Cool RH, Zhou L, Huang C, Dijkstra BW, Broos J.
J Am Chem Soc (2022 Aug)144:13815-13822
DOI: 10.1021/jacs.2c04986 |
PUBMED: 35868012 | IF(2018) = 14.7
PDB [P13]: 7QZ8
545: Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8.
Preussner M, Santos KF, Alles J, Heroven C, Heyd F, Wahl MC, Weber G.
Acta Crystallogr D Struct Biol (2022 Nov)78:1373-1383
DOI: 10.1107/s2059798322009755 |
PUBMED: 36322420 | IF(2018) = 3.2
PDB [P14]: 7PJH
544: Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases.
Verma A, Åberg-Zingmark E, Sparrman T, Mushtaq AU, Rogne P, Grundström C, Berntsson R, Sauer UH, Backman L, Nam K, Sauer-Eriksson E, Wolf-Watz M.
Sci Adv (2022 Nov)8:eabm4089
DOI: 10.1126/sciadv.abm4089 |
PUBMED: 36332013 | IF(2018) = 12.5
PDB [P13]: 7OWE
543: Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: towards a model of the C-P4H α2β2 tetramer.
Murthy AV, Sulu R, Lebedev A, Salo AM, Korhonen K, Venkatesan R, Tu H, Bergmann U, Jänis J, Laitaoja M, Ruddock L, Myllyharju J, Koski MK, Wierenga RK.
J Biol Chem (2022 Oct)UNK:102614
DOI: 10.1016/j.jbc.2022.102614 |
PUBMED: 36265586 | IF(2018) = 4.1
PDB [P14]: 7ZSC
542: Atomic resolution studies of S1 nuclease complexes reveal details of RNA interaction with the enzyme despite multiple lattice-translocation defects.
Adámková K, Koval' T, Østergaard LH, Dušková J, Malý M, Švecová L, Skálová T, Kolenko P, Dohnálek J.
Acta Crystallogr D Struct Biol (2022 Oct)78:1194-1209
DOI: 10.1107/s2059798322008397 |
PUBMED: 36189740 | IF(2018) = 3.2
PDB [P13]: 7QTB 7QTA
541: Structural insights into light-driven anion pumping in cyanobacteria.
Astashkin R, Kovalev K, Bukhdruker S, Vaganova S, Kuzmin A, Alekseev A, Balandin T, Zabelskii D, Gushchin I, Royant A, Volkov D, Bourenkov G, Koonin E, Engelhard M, Bamberg E, Gordeliy V.
Nat Commun (2022 Oct)13:6460
DOI: 10.1038/s41467-022-34019-9 |
PUBMED: 36309497 | IF(2022) = 14.9
PDB [P14]: 7ZOV 7ZOW 7ZOU
540: Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27.
Składanowska K, Bloch Y, Strand J, White KF, Hua J, Aldridge D, Welin M, Logan DT, Soete A, Merceron R, Murphy C, Provost M, Bazan JF, Hunter CA, Hill JA, Savvides SN.
Cell Rep (2022 Oct)41:111490
DOI: 10.1016/j.celrep.2022.111490 |
PUBMED: 36261006 | IF(2018) = 8.1
PDB [P14]: 7ZG0
539: Enzymatic Late-Stage Halogenation of Peptides.
Schnepel C, Moritzer AC, Gäfe S, Montua N, Minges H, Nieß A, Niemann HH, Sewald N.
ChemBioChem. (2022 Oct)UNK:pp. UNK
DOI: 10.1002/cbic.202200569 |
PUBMED: 36259362 | IF(2018) = 2.6
PDB [P13]: 8AD7
538: Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
Narayanan D, Tran KT, Pallesen JS, Solbak SMØ, Qin Y, Mukminova E, Luchini M, Vasilyeva KO, González Chichón D, Goutsiou G, Poulsen C, Haapanen N, Popowicz GM, Sattler M, Olagnier D, Gajhede M, Bach A.
J Med Chem. (2022 Oct)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.2c00830 |
PUBMED: 36263945 | IF(2018) = 6.1
PDB [P13P14]: 7OFD 7OFE
537: Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline Phosphatase.
Markússon S, Hjörleifsson JG, Kursula P, Ásgeirsson B.
Biochemistry (2022 Oct)61:2248-2260
DOI: 10.1021/acs.biochem.2c00438 |
PUBMED: 36194497 | IF(2018) = 3.0
PDB [P14]: 7QOW 7Z00
536: High-resolution structure of a fish aquaporin reveals a novel extracellular fold.
Zeng J, Schmitz F, Isaksson S, Glas J, Arbab O, Andersson M, Sundell K, Eriksson LA, Swaminathan K, Törnroth-Horsefield S, Hedfalk K.
Life Sci Alliance (2022 Oct)5:e202201491
DOI: 10.26508/lsa.202201491 |
PUBMED: 36229063
PDB [P13]: 7W7S
535: Evolution of increased complexity and specificity at the dawn of form I Rubiscos.
Schulz L, Guo Z, Zarzycki J, Steinchen W, Schuller JM, Heimerl T, Prinz S, Mueller-Cajar O, Erb TJ, Hochberg GKA.
Science (2022 Oct)378:155-160
DOI: 10.1126/science.abq1416 |
PUBMED: 36227987 | IF(2018) = 41.1
PDB [P14]: 7QSV 7QSW
534: Substrate Induced Movement of the Metal Cofactor between Active and Resting State.
Marsden SR, Wijma HJ, Mohr MKF, Justo I, Hagedoorn PL, Laustsen J, Jeffries CM, Svergun D, Mestrom L, McMillan DGG, Bento I, Hanefeld U.
Angew Chem Int Ed Engl. (2022 Oct)UNK:pp. UNK
DOI: 10.1002/anie.202213338 |
PUBMED: 36214476 | IF(2019) = 13.0
PDB [P13P14]: 7O9R 7O5W 7OBU 7O87 7NUJ 7NR1 7NNK 8ADQ 7O5I
533: Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics.
Zavarise A, Sridhar S, Kiema TR, Wierenga RK, Widersten M.
FEBS J. (2022 Aug)UNK:pp. UNK
DOI: 10.1111/febs.16603 |
PUBMED: 36002154 | IF(2018) = 4.7
PDB [P14]: 7QNI
532: Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
Weidenhausen J, Kopp J, Ruger-Herreros C, Stein F, Haberkant P, Lapouge K, Sinning I.
Int J Mol Sci (2022 Sep)23:10805
DOI: 10.3390/ijms231810805 |
PUBMED: 36142717 | IF(2018) = 4.2
PDB [P13]: 7OJU
531: Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.
Hyjek-Składanowska M, Anderson BA, Mykhaylyk V, Orr C, Wagner A, Poznański JT, Skowronek K, Seth P, Nowotny M.
Nucleic Acids Res. (2022 Sep)UNK:gkac774
DOI: 10.1093/nar/gkac774 |
PUBMED: 36124719 | IF(2018) = 11.1
PDB [P13]: 7ZVN
530: Deamidation of the human eye lens protein γS-crystallin accelerates oxidative aging.
Norton-Baker B, Mehrabi P, Kwok AO, Roskamp KW, Rocha MA, Sprague-Piercy MA, von Stetten D, Miller RJD, Martin RW.
Structure. (2022 May)30:763-776.e4
DOI: 10.1016/j.str.2022.03.002 |
PUBMED: 35338852 | IF(2022) = 5.0
PDB [P13P14]: 7N38 7N39 7N36 7N3A 7N3B 7N37
529: Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C.
Killer M, Finocchio G, Mertens HDT, Svergun DI, Pardon E, Steyaert J, Löw C.
Front Mol Biosci. 2022 Jul 11;9:917725.
DOI: 10.3389/fmolb.2022.917725 |
PUBMED: 35898305 | IF(2022) = 4.6
PDB [P13P14]:
528: Structure of an MHC I-tapasin-ERp57 editing complex defines chaperone promiscuity.
Müller IK, Winter C, Thomas C, Spaapen RM, Trowitzsch S, Tampé R.
Nat Commun. (2022 Sep)13:5383
DOI: 10.1038/s41467-022-32841-9 |
PUBMED: 36104323 | IF(2022) = 14.9
PDB [P13]: 7QNG
527: Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.
Gao S, Sylvester K, Song L, Claff T, Jing L, Woodson M, Weiße RH, Cheng Y, Schäkel L, Petry M, Gütschow M, Schiedel AC, Sträter N, Kang D, Xu S, Toth K, Tavis J, Tollefson AE, Müller CE, Liu X, Zhan P.
J Med Chem. (2022 Sep)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.2c01146 |
PUBMED: 36107752 | IF(2018) = 6.1
PDB [P13P14]: 8ACD 8ACL
526: Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Zeke A, Takács T, Sok P, Németh K, Kirsch K, Egri P, Póti ÁL, Bento I, Tusnády GE, Reményi A.
Nat Commun. (2022 Sep)13:5439
DOI: 10.1038/s41467-022-32918-5 |
PUBMED: 36114179 | IF(2022) = 14.9
PDB [P14]: 7PPL 7PPM 7PPN
525: Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Figiel M, Gapińska M, Czarnocki-Cieciura M, Zajko W, Sroka M, Skowronek K, Nowotny M.
Nucleic Acids Res. (2022 Sep)50:10026-10040
DOI: 10.1093/nar/gkac772 |
PUBMED: 36107766 | IF(2018) = 11.1
PDB [P14]: 7R07
524: Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Shvarev D, Schoppe J, König C, Perz A, Füllbrunn N, Kiontke S, Langemeyer L, Januliene D, Schnelle K, Kümmel D, Fröhlich F, Moeller A, Ungermann C.
Elife. (2022 Sep)11:e80901
DOI: 10.7554/elife.80901 |
PUBMED: 36098503 | IF(2018) = 7.6
PDB [P13]: 7ZTY
523: A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
Alexa A, Sok P, Gross F, Albert K, Kobori E, Póti ÁL, Gógl G, Bento I, Kuang E, Taylor SS, Zhu F, Ciliberto A, Reményi A.
Nat Commun. 2022 Jan 25;13(1):472.
DOI: 10.1038/s41467-022-28109-x |
PUBMED: 35078976 | IF(2022) = 14.9
PDB [P14]: 7OPO 7OPM
522: Crystal structures of free and ligand-bound forms of the TetR/AcrR-like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism.
Werten S, Waack P, Palm GJ, Virolle MJ, Hinrichs W.
FEBS J. (2022 Aug)UNK:pp. UNK
DOI: 10.1111/febs.16606 |
PUBMED: 36017630 | IF(2018) = 4.7
PDB [P13]: 7PT0
521: Structure of angiogenin dimer bound to double-stranded RNA.
Sievers K, Ficner R.
Acta Crystallogr F Struct Biol Commun (2022 Sep)78:330-337
DOI: 10.1107/s2053230x22008317 |
PUBMED: 36048083 | IF(2019) = 0.97
PDB [P14]: 8AF0
520: Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.
Truongvan N, Li S, Misra M, Kuhn M, Schindelin H.
Nat Commun. (2022 Aug)13:4789
DOI: 10.1038/s41467-022-32040-6 |
PUBMED: 35970836 | IF(2022) = 14.9
PDB [P14]: 7PVN
519: Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives.
Nogués I, Sekula B, Angelaccio S, Grzechowiak M, Tramonti A, Contestabile R, Ruszkowski M.
Plant Physiol Biochem. (2022 Jul)187:37-49
DOI: 10.1016/j.plaphy.2022.07.025 |
PUBMED: 35947902 | IF(2019) = 3.72
PDB [P14]: 7QPE
518: Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Pedersen H, Jensen RK, Hansen AG, Petersen SV, Thiel S, Laursen NS, Andersen GR.
Front Immunol. (2022 )13:872536
DOI: 10.3389/fimmu.2022.872536 |
PUBMED: 35935935 | IF(2018) = 6.4
PDB [P13]: 7QIV
517: An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Baker YR, Thorpe C, Chen J, Poller LM, Cox L, Kumar P, Lim WF, Lie L, McClorey G, Epple S, Singleton D, McDonough MA, Hardwick JS, Christensen KE, Wood MJA, Hall JP, El-Sagheer AH, Brown T.
Nat Commun. (2022 Jul)13:4036
DOI: 10.1038/s41467-022-31636-2 |
PUBMED: 35821218 | IF(2022) = 14.9
PDB [P13]: 7OZZ 7OOS
516: The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn2+ -binding domain essential for structural integrity and channel activity.
Sander S, Pick J, Gattkowski E, Fliegert R, Tidow H.
Protein Sci. (2022 Jun)31:e4320
DOI: 10.1002/pro.4320 |
PUBMED: 35634784 | IF(2018) = 2.4
PDB [P14]: 7AOV 7RU7
515: Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin.
Vourloumis D, Mavridis I, Athanasoulis A, Temponeras I, Koumantou D, Giastas P, Mpakali A, Magrioti V, Leib J, van Endert P, Stratikos E, Papakyriakou A.
J Med Chem. (2022 Jul)65:10098-10117
DOI: 10.1021/acs.jmedchem.2c00904 |
PUBMED: 35833347 | IF(2018) = 6.1
PDB [P13]: 7Z28 7ZYF
514: Structural Insights into the Role of β3 nAChR Subunit in the Activation of Nicotinic Receptors.
Giastas P, Papakyriakou A, Tsafaras G, Tzartos SJ, Zouridakis M.
Molecules. (2022 Jul)27:4642
DOI: 10.3390/molecules27144642 |
PUBMED: 35889515 | IF(2020) = 3.3
PDB [P13]: 8A5U
513: The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity.
Schweininger J, Kriegel M, Häge S, Conrad M, Alkhashrom S, Lösing J, Weiler S, Tillmanns J, Egerer-Sieber C, Decker A, Lenac Roviš T, Eichler J, Sticht H, Marschall M, Muller YA.
J Biol Chem. (2022 Mar)298:101625
DOI: 10.1016/j.jbc.2022.101625 |
PUBMED: 35074430 | IF(2018) = 4.1
PDB [P14]: 7PAB
512: Structural and biophysical studies of new L-asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn-amidohydrolase.
Loch JI, Klonecka A, Kądziołka K, Bonarek P, Barciszewski J, Imiolczyk B, Brzezinski K, Gilski M, Jaskolski M.
Acta Crystallogr D Struct Biol. (2022 Jul)78:911-926
DOI: 10.1107/s2059798322005691 |
PUBMED: 35775990 | IF(2018) = 3.2
PDB [P13]: 7QYM 7QY6 7QYX
511: Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.
Bisiak F, Chrenková A, Zhang SD, Pedersen JN, Otzen DE, Zhang YE, Brodersen DE.
J Biol Chem. (2022 Jun)UNK:102142
DOI: 10.1016/j.jbc.2022.102142 |
PUBMED: 35714769 | IF(2018) = 4.1
PDB [P13P14]: 7QOE 7QOC 7QOD
510: Crystal structures of the molecular class A β-lactamase TEM-171 and its complexes with tazobactam.
Grigorenko VG, Petrova TE, Carolan C, Rubtsova MY, Uporov IV, Pereira J, Chojnowski G, Samygina VR, Lamzin VS, Egorov AM.
Acta Crystallogr D Struct Biol. (2022 Jul)78:825-834
DOI: 10.1107/s2059798322004879 |
PUBMED: 35775982 | IF(2018) = 3.2
PDB [P14]: 7QOR
509: Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803.
Malecki PH, Imiolczyk B, Barciszewski J, Czyrko-Horczak J, Sliwiak J, Gawel M, Wozniak K, Jaskolski M, Brzezinski K.
Acta Crystallogr D Struct Biol. (2022 Jul)78:865-882
DOI: 10.1107/s2059798322005605 |
PUBMED: 35775986 | IF(2018) = 3.2
PDB [P13]: 7ZD7 7ZD8 7ZD9
508: Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors.
Burastero O, Defelipe LA, Gola G, Tateosian NL, Lopez ED, Martinena CB, Arcon JP, Traian MD, Wetzler DE, Bento I, Barril X, Ramirez J, Marti MA, Garcia-Alai MM, Turjanski AG.
J Med Chem. (2022 Jun)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c02012 |
PUBMED: 35737472 | IF(2018) = 6.1
PDB [P14]: 7Q52
507: New aspects of DNA recognition by group II WRKY transcription factor revealed by structural and functional study of AtWRKY18 DNA binding domain.
Grzechowiak M, Ruszkowska A, Sliwiak J, Urbanowicz A, Jaskolski M, Ruszkowski M.
Int J Biol Macromol. (2022 Jun)213:589-601
DOI: 10.1016/j.ijbiomac.2022.05.186 |
PUBMED: 35660042 | IF(2018) = 4.8
PDB [P14]: 7Z0U 7Z0R
506: Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1.
Sutinen A, Nguyen GTT, Raasakka A, Muruganandam G, Loris R, Ylikallio E, Tyynismaa H, Bartesaghi L, Ruskamo S, Kursula P.
FEBS Open Bio. (2022 May)UNK:pp. UNK
DOI: 10.1002/2211-5463.13422 |
PUBMED: 35509130
PDB [P13]: 7YWD
505: Direct interaction of a chaperone-bound type III secretion substrate with the export gate.
Gilzer D, Schreiner M, Niemann HH.
Nat Commun. (2022 Jun)13:2858
DOI: 10.1038/s41467-022-30487-1 |
PUBMED: 35654781 | IF(2022) = 14.9
PDB [P13]: 7QIJ
504: Ligandability Assessment of Human Glutathione Transferase M1-1 Using Pesticides as Chemical Probes.
Bodourian CS, Poudel N, Papageorgiou AC, Antoniadi M, Georgakis ND, Abe H, Labrou NE.
Int J Mol Sci. (2022 Mar)23:3606
DOI: 10.3390/ijms23073606 |
PUBMED: 35408962 | IF(2018) = 4.2
PDB [P13]: 7BEU
503: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.
Detry S, Andries J, Bloch Y, Gabay C, Clancy DM, Savvides SN
J Biol Chem. (2022 Apr)298:101908
DOI: 10.1016/j.jbc.2022.101908 |
PUBMED: 35398099 | IF(2018) = 4.1
PDB [-P14]: 7AL7
502: A GH115 α-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis.
Wilkens C, Vuillemin M, Pilgaard B, Polikarpov I, Morth JP.
Acta Crystallogr D Struct Biol. (2022 May)78:658-668
DOI: 10.1107/s2059798322003527 |
PUBMED: 35503213 | IF(2018) = 3.2
PDB [P14]: 7PUG
501: Family 1 Glycosyltransferase UGT706F8 from Zea mays Selectively Catalyzes the Synthesis of Silibinin 7-O-β-d-Glucoside.
Bidart GN, Putkaradze N, Fredslund F, Kjeldsen C, Ruiz AG, Duus JØ, Teze D, Welner DH.
ACS Sustain Chem Eng. (2022 Apr)10:5078-5083
DOI: 10.1021/acssuschemeng.1c07593 |
PUBMED: 35493695
PDB [P14]: 7Q3S
500: Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.
Balandis B, Šimkūnas T, Paketurytė-Latvė V, Michailovienė V, Mickevičiūtė A, Manakova E, Gražulis S, Belyakov S, Kairys V, Mickevičius V, Zubrienė A, Matulis D.
Pharmaceuticals. (Basel) (2022 Apr)15:477
DOI: 10.3390/ph15040477 |
PUBMED: 35455474
PDB [P13]: 7QGX 7QGZ
499: Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling.
Dubovskii PV, Dubova KM, Bourenkov G, Starkov VG, Konshina AG, Efremov RG, Utkin YN, Samygina VR.
Toxins. (Basel) (2022 Feb)14:149
DOI: 10.3390/toxins14020149 |
PUBMED: 35202176
PDB [P14]: 7QFC
498: Letter to the editor: The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein.
Struwe MA, Clement B, Scheidig A.
Hepatol Commun. (2022 May)UNK:pp. UNK
DOI: 10.1002/hep4.1984 |
PUBMED: 35560545
PDB [P14]: 7P41
497: Binding of VIVO2+, VIVOL+, VIVOL2 and VVO2L moieties to proteins: X-ray/theoretical characterization and biological implications.
Santos MFA, Sciortino G, Correia I, Fernandes ACP, Santos-Silva T, Pisanu F, Garribba E, Pessoa JC.
Chemistry. (2022 Apr)UNK:pp. UNK
DOI: 10.1002/chem.202200105 |
PUBMED: 35486702 | IF(2019) = 4.9
PDB [P13]: 7Q0W
496: Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5′-monophosphate decarboxylase catalysis
Rindfleisch S, Krull M, Uranga J, et al. , Tittmann K
Nat Catal. 5: 332-341 (2022)
DOI: 10.1038/s41929-022-00771-w |
PUBMED: | IF(2021) = 47.2
PDB [P13P14]: 7AM9 6YVL 6YVM 6YVK 6YVN 7ASQ 7OQI 7OUZ 7OTU 7OQK 7OQN 7OV0 7OQM 6ZX0 6ZX1 6YVO 6YWU 6ZX3 6ZX2 6YWT 6ZWY 6ZWZ 7OQF 7Q1H
495: The Structure of Bilirubin Oxidase from Bacillus pumilus Reveals a Unique Disulfide Bond for Site-Specific Direct Electron Transfer.
Gihaz S, Herzallh NS, Cohen Y, Bachar O, Fishman A, Yehezkeli O.
Biosensors. (Basel) (2022 Apr)12:258
DOI: 10.3390/bios12050258 |
PUBMED: 35624560
PDB [P14]: 7Z5P
494: Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Pazicky S, Werle AA, Lei J, Löw C, Weininger U.
Cell Mol Life Sci. (2022 Feb)79:138
DOI: 10.1007/s00018-022-04179-4 |
PUBMED: 35184231 | IF(2018) = 7.0
PDB [P13]: 7OXI 7OXK 7OXG 7OXJ 7OXH
493: A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function.
Minadakis MP, Mavreas KF, Neofytos DD, Paschou M, Kogkaki A, Athanasiou V, Mamais M, Veclani D, Iatrou H, Venturini A, Chrysina ED, Papazafiri P, Gimisis T.
Org Biomol Chem. (2022 Mar)20:2407-2423
DOI: 10.1039/d1ob02211c |
PUBMED: 35119451
PDB [P13]: 7Q5I
492: GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway.
Kroef V, Ruegenberg S, Horn M, Allmeroth K, Ebert L, Bozkus S, Miethe S, Elling U, Schermer B, Baumann U, Denzel MS.
Elife. (2022 Mar)11:pp. UNK
DOI: 10.7554/elife.69223 |
PUBMED: 35229715 | IF(2018) = 7.6
PDB [P13]: 7NUU
491: Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations.
Sonani RR, Blat A, Dubin G.
Int J Biol Macromol. (2022 Feb)205:203-210
DOI: 10.1016/j.ijbiomac.2022.02.008 |
PUBMED: 35149097 | IF(2018) = 4.8
PDB [P13]: 7Q84
490: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis.
Albert L, Nagpal J, Steinchen W, Zhang L, Werel L, Djokovic N, Ruzic D, Hoffarth M, Xu J, Kaspareit J, Abendroth F, Royant A, Bange G, Nikolic K, Ryu S, Dou Y, Essen LO, Vázquez O.
ACS Cent Sci. (2022 Jan)8:57-66
DOI: 10.1021/acscentsci.1c00434 |
PUBMED: 35106373
PDB [P13]: 7AXP
489: Structural and Functional Characterization of Camelus dromedarius Glutathione Transferase M1-1.
Perperopoulou F, Poudel N, Papageorgiou AC, Ataya FS, Labrou NE.
Life. (Basel) (2022 Jan)12:pp. UNK
DOI: 10.3390/life12010106 |
PUBMED: 35054499
PDB [P13]: 7OPY 7OPZ
488: Rare by Natural Selection: Disulfide-Bonded Supramolecular Antimicrobial Peptides.
Engelberg Y, Ragonis-Bachar P, Landau M.
Biomacromolecules. (2022 Jan)UNK:pp. UNK
DOI: 10.1021/acs.biomac.1c01353 |
PUBMED: 35061360
PDB [P14]: 7NPQ
487: Identification of molecular basis that underlie enzymatic specificity of AzoRo from Rhodococcus opacus 1CP: A potential NADH:quinone oxidoreductase.
Ngo ACR, Qi J, Juric C, Bento I, Tischler D.
Arch Biochem Biophys. (2022 Mar)717:109123
DOI: 10.1016/j.abb.2022.109123 |
PUBMED: 35051387
PDB [P13]: 7AWV
486: Widespread occurrence of covalent lysine-cysteine redox switches in proteins.
Rabe von Pappenheim F, Wensien M, Ye J, Uranga J, Irisarri I, de Vries J, Funk LM, Mata RA, Tittmann K.
Nat Chem Biol. (2022 Feb)UNK:pp. UNK
DOI: 10.1038/s41589-021-00966-5 |
PUBMED: 35165445 | IF(2020) = 41.8
PDB [P14]: 7ODO 7ODQ 7O9G 7ODP 7OEY
485: Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2.
Mpakali A, Georgiadis D, Stratikos E, Giastas P.
ACS Med Chem Lett. (2022 Feb)13:218-224
DOI: 10.1021/acsmedchemlett.1c00582 |
PUBMED: 35178178 | IF(2018) = 3.7
PDB [P13]: 7P7P 7PFS
484: A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat.
Geerds C, Bleymüller WM, Meyer T, Widmann C, Niemann HH.
Acta Crystallogr D Struct Biol. (2022 Mar)78:310-320
DOI: 10.1107/s2059798322000432 |
PUBMED: 35234145 | IF(2018) = 3.2
PDB [P13]: 7PV9
483: Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.
Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A.
PLoS Pathog. (2022 Jan)18:e1010166
DOI: 10.1371/journal.ppat.1010166 |
PUBMED: 35007292 | IF(2018) = 6.1
PDB [P13]: 6T5I
482: Best practices for time-resolved serial synchrotron crystallography.
Schulz EC, Yorke BA, Pearson AR, Mehrabi P.
Acta Crystallogr D Struct Biol. 2022;78(Pt 1):14-29.
DOI: 10.1107/S2059798321011621 |
PUBMED: 34981758 | IF(2018) = 3.2
PDB [P14]:
481: Structure, dynamics, and function of SrnR, a transcription factor for nickel-dependent gene expression.
Mazzei L, Musiani F, Żerko S, Koźminski W, Cianci M, Beniamino Y, Ciurli S, Zambelli B.
Metallomics (2021 Dec)13:mfab069
DOI: 10.1093/mtomcs/mfab069 |
PUBMED: 34850061
PDB [P13]: 7P6F
480: The Bacteroidetes Aequorivita sp. and Kaistella jeonii Produce Promiscuous Esterases With PET-Hydrolyzing Activity.
Zhang H, Perez-Garcia P, Dierkes RF, Applegate V, Schumacher J, Chibani CM, Sternagel S, Preuss L, Weigert S, Schmeisser C, Danso D, Pleiss J, Almeida A, Höcker B, Hallam SJ, Schmitz RA, Smits SHJ, Chow J, Streit WR.
Front Microbiol (2021 )12:803896
DOI: 10.3389/fmicb.2021.803896 |
PUBMED: 35069509 | IF(2019) = 4.2
PDB [P13]: 7PZJ
479: Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX.
Zakšauskas A, Čapkauskaitė E, Paketurytė-Latvė V, Smirnov A, Leitans J, Kazaks A, Dvinskis E, Stančaitis L, Mickevičiūtė A, Jachno J, Jezepčikas L, Linkuvienė V, Sakalauskas A, Manakova E, Gražulis S, Matulienė J, Tars K, Matulis D.
Int J Mol Sci (2021 Dec)23:pp. UNK
DOI: 10.3390/ijms23010130 |
PUBMED: 35008553
PDB [P13P14]: 7Q0D 7PUU 7PUW 7Q0E 7PUV 7Q0C
478: Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii
Marchetti GM, Fusser F, Singh RK, Brummel M, Koch O, Kummel D, Hippler M
J Struct Biol (2021 Dec)214:107829
DOI: 10.1016/j.jsb.2021.107829 |
PUBMED: 34974142 | IF(2018) = 3.8
PDB [P13]: 7P9D 7P9E
477: Broken symmetry between RNA enantiomers in a crystal lattice.
Kiliszek A, Błaszczyk L, Bejger M, Rypniewski W.
Nucleic Acids Res (2021 Jun)UNK:pp. UNK
DOI: 10.1093/nar/gkab480 |
PUBMED: 34107036
PDB [P13]: 7A9T 7A9O 6ZWU 6ZPF 6ZX5 6ZR1 6ZRL 6ZQ9 6ZW3 6ZRS 7A9N
476: Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms.
Ornik-Cha A, Wilhelm J, Kobylka J, Sjuts H, Vargiu AV, Malloci G, Reitz J, Seybert A, Frangakis AS, Pos KM.
Nat Commun. (2021 Nov)12:6919
DOI: 10.1038/s41467-021-27146-2 |
PUBMED: 34824229 | IF(2022) = 14.9
PDB [P13P14]: 7B8R 7B8S
475: Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP.
J Med Chem (2021 Nov)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c00804 |
PUBMED: 34807584
PDB [P13]: 6YAT
474: The elusive Rhizobium etli L-asparaginase has a novel fold and peculiar active site
Loch JI, Imiolczyk B, Sliwiak J, Wantuch A, Bejger M, Gilski M, Jaskolski M
Nat Commun. (2021 Nov)12:6717
DOI: 10.1038/s41467-021-27105-x |
PUBMED: 34795296 | IF(2022) = 14.9
PDB [P13]: 7OS5 7OS3 7OS6
473: Role of hydrogen bond alternation and charge transfer states in photoactivation of the Orange Carotenoid Protein.
Yaroshevich IA, Maksimov EG, Sluchanko NN, Zlenko DV, Stepanov AV, Slutskaya EA, Slonimskiy YB, Botnarevskii VS, Remeeva A, Gushchin I, Kovalev K, Gordeliy VI, Shelaev IV, Gostev FE, Khakhulin D, Poddubnyy VV, Gostev TS, Cherepanov DA, Polívka T, Kloz M, Friedrich T, Paschenko VZ, Nadtochenko VA, Rubin AB, Kirpichnikov MP.
Communications Biology. 2021 May;4(1):539.
DOI: 10.1038/s42003-021-02022-3. |
PUBMED: 33972665
PDB [P14]: 6T6O 6T6M 6T6K
472: Homogeneous batch micro-crystallization of proteins from ammonium sulfate.
Stohrer C, Horrell S, Meier S, et al.
Acta crystallographica. Section D, Structural Biology. 2021 Feb;77(Pt 2):194-204.
DOI: 10.1107/s2059798320015454. |
PUBMED: 33559608; PMCID: PMC7869895.
PDB [P14]:
471: DYW domain structures imply an unusual regulation principle in plant organellarRNA editing catalysis.
Takenaka M, Takenaka S, Barthel T, Frink B, Haag S, Verbitskiy D, Oldenkott B, Schallenberg-Rudinger M, Feiler CG, Weiss MS, Palm GJ, Weber G,
Nat Catal. 2021 Jun;4(6):510-522. doi: 10.1038/s41929-021-00633-x. Epub 2021 Jun 21.
DOI: 10.1038/s41929-021-00633-x [doi] |
PUBMED: 34712911 | IF(2021) = 47.2
PDB [P13]:
470: Conformational interplay in hybrid peptide-helical aromatic foldamer macrocycles.
Dengler S, Mandal PK, Allmendinger L, Douat C, Huc I,
Chem Sci. 2021 Jul 27;12(33):11004-11012. doi: 10.1039/d1sc03640h. eCollection2021 Aug 25.
DOI: 10.1039/d1sc03640h [doi] |
PUBMED: 3452229
PDB [P13]:
469: Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C.
Wallerstein J, Ekberg V, Ignjatovic MM, Kumar R, Caldararu O, Peterson K, Wernersson S, Brath U, Leffler H, Oksanen E, Logan DT, Nilsson UJ, Ryde U, Akke M,
JACS Au. 2021 Apr 1;1(4):484-500. doi: 10.1021/jacsau.0c00094. eCollection 2021Apr 26.
DOI: 10.1021/jacsau.0c00094 [doi] |
PUBMED: 34467311
PDB [P13]: 6RZF 6RZG 6RZH
468: Structural Characterization of EnpA D,L-Endopeptidase from Enterococcus faecalis Prophage Provides Insights into Substrate Specificity of M23 Peptidases.
Malecki PH, Mitkowski P, Jagielska E, Trochimiak K, Mesnage S, Sabala I,
Int J Mol Sci. 2021 Jul 1;22(13). pii: ijms22137136. doi: 10.3390/ijms22137136.
DOI: 10.3390/ijms22137136 |
PUBMED: 34281200 | IF(2018) = 4.2
PDB [P13]: 6SMK
467: Calmodulin complexes with brain and muscle creatine kinase peptides.
Sprenger J, Trifan A, Patel N, Vanderbeck A, Bredfelt J, Tajkhorshid E, Rowlett R, Lo Leggio L, Akerfeldt KS, Linse S,
Curr Res Struct Biol. 2021 May 19;3:121-132. doi: 10.1016/j.crstbi.2021.05.001.eCollection 2021.
DOI: 10.1016/j.crstbi.2021.05.001 [doi] |
PUBMED: 34235492
PDB [P13P14]:
466: Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase.
Nowacka M, Nowak E, Czarnocki-Cieciura M, Jackiewicz J, Skowronek K, Szczepanowski RH, Wohrl BM, Nowotny M,
J Virol. 2021 Aug 25;95(18):e0084821. doi: 10.1128/JVI.00848-21. Epub 2021 Aug25.
DOI: 10.1128/JVI.00848-21 [doi] |
PUBMED: 34232702 | IF(2018) = 4.3
PDB [P13]: 7O0G
465: Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-NaphthalimideDerivatives as Potential Anticancer Agents.
Rykowski S, Gurda-Wozna D, Orlicka-Plocka M, Fedoruk-Wyszomirska A, Giel-Pietraszuk M, Wyszko E, Kowalczyk A, Staczek P, Bak A, Kiliszek A, Rypniewski W, Olejniczak AB,
Int J Mol Sci. 2021 Mar 9;22(5). pii: ijms22052772. doi: 10.3390/ijms22052772.
DOI: 10.3390/ijms22052772 |
PUBMED: 33803403 | IF(2018) = 4.2
PDB [P13]:
464: Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
Wortmann L, Bräuer N,Holton SJ, Irlbacher H, Weiske J, Lechner C, Meier R, Karén J, Siöberg CB, Pütter V, Christ CD, Ter Laak A, Lienau P, Lesche R, Nicke B, Cheung SH, Bauser M, Haegebarth A, von Nussbaum F, Mumberg D, Lemos C.
J Med Chem. 2021 Nov 11;64(21):15883-15911.
DOI: 10.1021/acs.jmedchem.1c01245. |
PUBMED: 34699202. | IF(2018) = 6.1
PDB [P14]: 6YM5
463: An automated platform for structural analysis of membrane proteins through serial crystallography.
Healey RD, Basu S, Humm AS, Leyrat C, Cong X, Golebiowski J, Dupeux F, Pica A, Granier S, Márquez JA.
Cell Rep Methods.
DOI: 10.1016/j.crmeth.2021.100102. |
PUBMED: 34723237
PDB [P14]: 6YXD
462: Wilavidin* - a novel member of the avidin family that forms unique biotin-binding hexamers.
Avraham O, Bayer EA, Livnah O.
FEBS J.
DOI: 10.1111/febs.16259. |
PUBMED: 34726340 | IF(2018) = 4.7
PDB [P13]: 7OUQ
461: Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Dolot R, Krakowiak A, Kaczmarek R, Włodarczyk A, Pichlak M, Nawrot B.
Biochim Biophys Acta Gen Subj (2021 Nov)1865:129968
DOI: 10.1016/j.bbagen.2021.129968 |
PUBMED: 34329705
PDB [P13]: 6YPR 6YQD 6YPX
460: Insights into Broad-Specificity Starch Modification from the Crystal Structure of Limosilactobacillus Reuteri NCC 2613 4,6-α-Glucanotransferase GtfB.
Pijning T, Gangoiti J, Te Poele EM, Börner T, Dijkhuizen L.
J Agric Food Chem. 2021 Oct 28.
DOI: 10.1021/acs.jafc.1c05657. |
PUBMED: 34708648.
PDB [P14]: 7P38
459: Profiling cellular diversity in sponges informs animal cell type and nervous system evolution.
Musser JM, Schippers KJ, Nickel M, Mizzon G, Kohn AB, Pape C, Ronchi P, Papadopoulos N, Tarashansky AJ, Hammel JU, Wolf F, Liang C, Hernández-Plaza A, Cantalapiedra CP, Achim K, Schieber NL, Pan L, Ruperti F, Francis WR, Vargas S, Kling S, Renkert M, Polikarpov M, Bourenkov G, Feuda R, Gaspar I, Burkhardt P, Wang B, Bork P, Beck M, Schneider TR, Kreshuk A, Wörheide G, Huerta-Cepas J, Schwab Y, Moroz LL, Arendt D.
Science. 2021 Nov 5;374(6568):717-723.
DOI: 10.1126/science.abj2949. |
PUBMED: 34735222. | IF(2018) = 41.1
PDB [P14]:
458: Structural basis of cytokine-mediated activation of ALK family receptors.
De Munck S, Provost M, Kurikawa M, Omori I, Mukohyama J, Felix J, Bloch Y, Abdel-Wahab O, Bazan JF, Yoshimi A, Savvides SN.
Nature. (2021 Oct 13). Epub ahead of print
DOI: 10.1038/s41586-021-03959-5 |
PUBMED: 34646012 | IF(2018) = 43.1
PDB [P13P14]: 7NX4 7NX2 7NX1
457: Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation-π interaction.
Helfrich F, Scheidig AJ.
Acta Crystallogr D Struct Biol (2021 Oct)77:1317-1335
DOI: 10.1107/s2059798321008937 |
PUBMED: 34605434 | IF(2018) = 3.2
PDB [P13P14]: 6Y87 6SEP 6S6G 4W8G 6S49 6S4D 6S65 6S3X 6S72
456: 3D Domain Swapping Dimerization of the Receiver Domain of Cytokinin Receptor CRE1 From Arabidopsis thaliana and Medicago truncatula.
Tran LH, Urbanowicz A, Jasiński M, Jaskolski M, Ruszkowski M.
Front Plant Sci (2021 )12:756341
DOI: 10.3389/fpls.2021.756341 |
PUBMED: 34630499 | IF(2016) = 4.4
PDB [P13]: 7P8E 7P8D 7P8C
455: Medicinal Au(I) compounds targeting urease as prospective antimicrobial agents: unveiling the structural basis for enzyme inhibition.
Mazzei L, Massai L, Cianci M, Messori L, Ciurli S.
Dalton Trans. 2021;50(40):14444-14452.
DOI: 10.1039/d1dt02488d |
PUBMED: 34585201
PDB [P13]: 7P7N 7P7O
454: Kinetic and structural analysis of the inactivation of urease by mixed-ligand phosphine halide Ag(I) complexes.
Mazzei L, Cirri D, Cianci M, Messori L, Ciurli S.
J Inorg Biochem. (2021 May)218:111375
DOI: 10.1016/j.jinorgbio.2021.111375 |
PUBMED: 33711632
PDB [P13]: 7B58 7B5A 7B59
453: Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket.
Grininger C, Leypold M, Aschauer P, Pavkov-Keller T, Riegler-Berket L, Breinbauer R, Oberer M.
Biomolecules. (2021 Sep)11:pp. UNK
DOI: 10.3390/biom11091299 |
PUBMED: 34572512 | IF(2019) = 4.7
PDB [P13]: 7OZM
452: The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes.
Osorio-Valeriano M, Altegoer F, Das CK, Steinchen W, Panis G, Connolley L, Giacomelli G, Feddersen H, Corrales-Guerrero L, Giammarinaro PI, Hanßmann J, Bramkamp M, Viollier PH, Murray S, Schäfer LV, Bange G, Thanbichler M.
Mol Cell. (2021 Oct)81:3992-4007.e10
DOI: 10.1016/j.molcel.2021.09.004 |
PUBMED: 34562373 | IF(2018) = 14.5
PDB [P14]: 7BNR
451: Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Nair RM, Seenivasan A, Liu B, Chen D, Lowe ED, Lorenz S.
ACS Chem Biol. (2021 Sep)16:1615-1621
DOI: 10.1021/acschembio.1c00433 |
PUBMED: 34403242 | IF(2019) = 4.43
PDB [P13]: 6XZ1
450: Crystal structure of Z-DNA in complex with the polyamine putrescine and potassium cations at ultra-high resolution.
Drozdzal P, Gilski M, Jaskolski M.
Acta Crystallogr B Struct Sci Cryst Eng Mater. (2021 Jun)77:331-338
DOI: 10.1107/s2052520621002663 |
PUBMED: 34096514
PDB [P13]: 7ATG
449: Considerations Regarding Activity Determinants of Fungal Polyphenol Oxidases Based on Mutational and Structural Studies.
Nikolaivits E, Valmas A, Dedes G, Topakas E, Dimarogona M.
Appl Environ Microbiol. (2021 May)87:pp. UNK
DOI: 10.1128/aem.00396-21 |
PUBMED: 33741634
PDB [P14]: 6Z1S
448: Engineering a Highly Efficient Carboligase for Synthetic One-Carbon Metabolism.
Nattermann M, Burgener S, Pfister P, Chou A, Schulz L, Lee SH, Paczia N, Zarzycki J, Gonzalez R, Erb TJ.
ACS Catal. (2021 May)11:5396-5404
DOI: 10.1021/acscatal.1c01237 |
PUBMED: 34484855 | IF(2018) = 12.1
PDB [P13]: 7B2E
447: Glycogen phosphorylase revisited: extending the resolution of the R- and T-state structures of the free enzyme and in complex with allosteric activators.
Leonidas DD, Zographos SE, Tsitsanou KE, Skamnaki VT, Stravodimos G, Kyriakis E.
Acta Crystallogr F Struct Biol Commun. (2021 Sep)77:303-311
DOI: 10.1107/s2053230x21008542 |
PUBMED: 34473107 | IF(2019) = 0.97
PDB [P13]: 7P7D
446: Cesium based phasing of macromolecules: a general easy to use approach for solving the phase problem.
Koelmel W, Kuper J, Kisker C.
Sci Rep. (2021 Aug)11:17038
DOI: 10.1038/s41598-021-95186-1 |
PUBMED: 34426585 | IF(2022) = 5.0
PDB [P14]: 7BMR 7BMU 7BMO 7BMQ
445: BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture.
Bandera AM, Bartho J, Lammens K, Drexler DJ, Kleinschwärzer J, Hopfner KP, Witte G.
Nucleic Acids Res. (2021 Sep)49:10166-10177
DOI: 10.1093/nar/gkab736 |
PUBMED: 34432045 | IF(2018) = 11.1
PDB [P13P14]: 7B5U 7B5T 7B5W
444: Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.
Fauser J, Gulen B, Pogenberg V, Pett C, Pourjafar-Dehkordi D, Krisp C, Höpfner D, König G, Schlüter H, Feige MJ, Zacharias M, Hedberg C, Itzen A.
Nat Commun. (2021 Apr)12:2426
DOI: 10.1038/s41467-021-22596-0 |
PUBMED: 33893288 | IF(2022) = 14.9
PDB [P13]: 6ZMD
443: Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli.
Hamborg L, Granata D, Olsen JG, Roche JV, Pedersen LE, Nielsen AT, Lindorff-Larsen K, Teilum K.
Commun Biol. (2021 Aug)4:980
DOI: 10.1038/s42003-021-02490-7 |
PUBMED: 34408246 | IF(2019) = 12.1
PDB [P13P14]: 7A3M 7AON 7AOK
442: Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.
Masuyer G, Davies JR, Stenmark P.
Int J Mol Sci. (2021 Aug)22:pp. UNK
DOI: 10.3390/ijms22158315 |
PUBMED: 34361086 | IF(2018) = 4.2
PDB [P13]: 7OVW
441: Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria.
Freischem S, Grimm I, López-Pérez A, Willbold D, Klenke B, Vuong C, Dingley AJ, Weiergräber OH.
Biomolecules. (2021 Jul)11:pp. UNK
DOI: 10.3390/biom11071057 |
PUBMED: 34356681 | IF(2019) = 4.7
PDB [P13]: 7ONY 7ONZ
440: Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA.
Blersch KF, Burchert JP, August SC, Welp L, Neumann P, Köster S, Urlaub H, Ficner R.
RNA Biol. (2021 May)UNK:1-14
DOI: 10.1080/15476286.2021.1925477 |
PUBMED: 34006170
PDB [P13]: 7NZJ 7NYB
439: Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers.
Schweininger J, Scherer M, Rothemund F, Schilling EM, Wörz S, Stamminger T, Muller YA.
PLoS Pathog. (2021 Aug)17:e1009863
DOI: 10.1371/journal.ppat.1009863 |
PUBMED: 34370791 | IF(2018) = 6.1
PDB [P13]: 6TGZ
438: Structure and mechanism of secondary sulfonamide binding to carbonic anhydrases.
Baronas D, Dudutienė V, Paketurytė V, Kairys V, Smirnov A, Juozapaitienė V, Vaškevičius A, Manakova E, Gražulis S, Zubrienė A, Matulis D.
Eur Biophys J. (2021 Jul)UNK:pp. UNK
DOI: 10.1007/s00249-021-01561-1 |
PUBMED: 34328515
PDB [P13P14]: 7AES 7AEQ 7AGN
437: Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants.
Uusitalo M, Klenow MB, Laulumaa S, Blakeley MP, Simonsen AC, Ruskamo S, Kursula P.
FEBS J. (2021 Jun)UNK:pp. UNK
DOI: 10.1111/febs.16079 |
PUBMED: 34138518 | IF(2018) = 4.7
PDB [P13]: 7NRW
436: Conformational changes of loops highlight a potential binding site in Rhodococcus equi VapB.
Geerds C, Haas A, Niemann HH.
Acta Crystallogr F Struct Biol Commun. (2021 Aug)77:246-253
DOI: 10.1107/s2053230x2100738x |
PUBMED: 34341190 | IF(2019) = 0.97
PDB [P14]: 7B1Z
435: Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis β-oxidation trifunctional enzyme.
Dalwani S, Lampela O, Leprovost P, Schmitz W, Juffer AH, Wierenga RK, Venkatesan R.
J Struct Biol. (2021 Aug)213:107776
DOI: 10.1016/j.jsb.2021.107776 |
PUBMED: 34371166 | IF(2018) = 3.8
PDB [P13]: 7O4T
434: The induction mechanism of the flavonoid-responsive regulator FrrA.
Werner N, Werten S, Hoppen J, Palm GJ, Göttfert M, Hinrichs W.
FEBS J. (2021 Jul)UNK:pp. UNK
DOI: 10.1111/febs.16141 |
PUBMED: 34314575 | IF(2018) = 4.7
PDB [P13]: 6G8H 6G8G
433: NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
Baggio C, Kulinich A, Dennys CN, Rodrigo R, Meyer K, Ethell I, Pellecchia M.
J Med Chem. (2021 Jul)UNK:pp. UNK
DOI: 10.1021/acs.jmedchem.1c00608 |
PUBMED: 34293864 | IF(2018) = 6.1
PDB [P13]: 7OFV
432: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Verstraete K, Verschueren KHG, Dansercoer A, Savvides SN.
Nat Struct Mol Biol. 2021 Aug;28(8):636-638. Epub 2021 Jul 22.
DOI: 10.1038/s41594-021-00624-3 |
PUBMED: 34294920 | IF(2019) = 11.7
PDB [P14]: 6ZNW
431: Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography.
Geier B, Oetjen J, Ruthensteiner B, Polikarpov M, Gruber-Vodicka HR, Liebeke M.
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2023773118.
DOI: 10.1073/pnas.2023773118. |
PUBMED: 34183413 | IF(2019) = 9.4
PDB [P14]:
430: Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps.
Kelpšas V, Caldararu O, Blakeley MP, Coquelle N, Wierenga RK, Ryde U, von Wachenfeldt C, Oksanen E.
IUCrJ. (2021 Jul)8:633-643
DOI: 10.1107/s2052252521004619 |
PUBMED: 34258011 | IF(2020) = 4
PDB [P14]: 7AZ9 7AZA
429: Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii.
Krska D, Mazurkewich S, Brown HA, Theibich Y, Poulsen JN, Morris AL, Koropatkin NM, Lo Leggio L, Larsbrink J.
Biochemistry. (2021 Jul)60:2206-2220
DOI: 10.1021/acs.biochem.1c00305 |
PUBMED: 34180241 | IF(2018) = 3.0
PDB [P13]: 7NWO 7NWQ
428: Insights into the Protein Ruthenation Mechanism by Antimetastatic Metallodrugs: High-Resolution X-ray Structures of the Adduct Formed between Hen Egg-White Lysozyme and NAMI-A at Various Time Points.
Chiniadis L, Giastas P, Bratsos I, Papakyriakou A.
Inorg Chem. (2021 Jul)60:10729-10737
DOI: 10.1021/acs.inorgchem.1c01441 |
PUBMED: 34197115 | IF(2019) = 4
PDB [P13]: 7BCX 7BD0 7BDM 7BCU
427: Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners.
Marcelot A, Petitalot A, Ropars V, Le Du MH, Samson C, Dubois S, Hoffmann G, Miron S, Cuniasse P, Marquez JA, Thai R, Theillet FX, Zinn-Justin S.
Nucleic Acids Res. (2021 Apr)49:3841-3855
DOI: 10.1093/nar/gkab184 |
PUBMED: 33744941 | IF(2018) = 11.1
PDB [P14]: 7ABM
426: A computationally designed β-amino acid-containing miniprotein.
Bejger M, Fortuna P, Drewniak-Switalska M, Plewka J, Rypniewski W, Berlicki Ł.
Chem Commun. (Camb) (2021 Jun)57:6015-6018
DOI: 10.1039/d1cc02192c |
PUBMED: 34032224 | IF(2019) = 5.996
PDB [P13]: 7ARR 7ARS
425: Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan.
Sprenger J, Lawson CL, von Wachenfeldt C, Lo Leggio L, Carey J.
Acta Crystallogr F Struct Biol Commun. (2021 Jul)77:215-225
DOI: 10.1107/s2053230x21006142 |
PUBMED: 34196612 | IF(2019) = 0.97
PDB [P13]: 7OS9
424: Snapshots of a Non-Canonical RdRP in Action.
Ferrero DS, Falqui M, Verdaguer N.
Viruses. (2021 Jun)13:pp. UNK
DOI: 10.3390/v13071260 |
PUBMED: 34203380 | IF(2020) = 5.048
PDB [P13]: 7OMA 7OM7
423: Structure of the mycobacterial ESX-5 type VII secretion system pore complex.
Beckham KSH, Ritter C, Chojnowski G, Ziemianowicz DS, Mullapudi E, Rettel M, Savitski MM, Mortensen SA, Kosinski J, Wilmanns M.
Sci Adv. 2021 Jun 25;7(26):eabg9923.
DOI: 10.1126/sciadv.abg9923 |
PUBMED: 34172453 | IF(2018) = 12.5
PDB [P13]: 7B7J
422: Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1.
Orth B, Sander B, Möglich A, Diederichs K, Eilers M, Lorenz S.
Structure. (2021 Jun)UNK:pp. UNK
DOI: 10.1016/j.str.2021.06.005 |
PUBMED: 34186024 | IF(2022) = 5.0
PDB [P13]: 7AZW
421: Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.
Samarina N, Ssebyatika G, Tikla T, Waldmann JY, Abere B, Nanna V, Marasco M, Carlomagno T, Krey T, Schulz TF.
PLoS Pathog. (2021 Jun)17:e1009635
DOI: 10.1371/journal.ppat.1009635 |
PUBMED: 34143834 | IF(2018) = 6.1
PDB [P13]: 7NXE
420: Allosteric drug transport mechanism of multidrug transporter AcrB.
Tam HK, Foong WE, Oswald C, Herrmann A, Zeng H, Pos KM.
Nat Commun. (2021 Jun)12:3889
DOI: 10.1038/s41467-021-24151-3 |
PUBMED: 34188038 | IF(2022) = 14.9
PDB [P13]: 6ZOG
419: Discovery of fungal surface NADases predominantly present in pathogenic species.
Strømland Ø, Kallio JP, Pschibul A, Skoge RH, Harðardóttir HM, Sverkeli LJ, Heinekamp T, Kniemeyer O, Migaud M, Makarov MV, Gossmann TI, Brakhage AA, Ziegler M.
Nat Commun. (2021 Mar)12:1631
DOI: 10.1038/s41467-021-21307-z |
PUBMED: 33712585 | IF(2022) = 14.9
PDB [P13]: 6YGE
418: Mutation-induced dimerization of transforming growth factor-β-induced protein may drive protein aggregation in granular corneal dystrophy.
Nielsen NS, Gadeberg TAF, Poulsen ET, Harwood SL, Weberskov CE, Pedersen JS, Andersen GR, Enghild JJ.
J Biol Chem. (2021 Jun)297:100858
DOI: 10.1016/j.jbc.2021.100858 |
PUBMED: 34097874 | IF(2018) = 4.1
PDB [P13P14]: 7AS7 7ASC 7ASG
417: Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2.
Czapinska H, Winiewska-Szajewska M, Szymaniec-Rutkowska A, Piasecka A, Bochtler M, Poznański J.
J Phys Chem B. (2021 Mar)125:2491-2503
DOI: 10.1021/acs.jpcb.0c10264 |
PUBMED: 33689348
PDB [P14]: 6TLU 6TLS 6TLV 6TLL 6TLO 6TLR 6TLW
416: Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin.
Sponga A, Arolas JL, Schwarz TC, Jeffries CM, Rodriguez Chamorro A, Kostan J, Ghisleni A, Drepper F, Polyansky A, De Almeida Ribeiro E, Pedron M, Zawadzka-Kazimierczuk A, Mlynek G, Peterbauer T, Doto P, Schreiner C, Hollerl E, Mateos B, Geist L, Faulkner G, Kozminski W, Svergun DI, Warscheid B, Zagrovic B, Gautel M, Konrat R, Djinović-Carugo K.
Sci Adv. 2021 May 28; 7(22):eabg7653.
DOI: 10.1126/sciadv.abg7653 |
PUBMED: 34049882 | IF(2018) = 12.5
PDB [P14]: 7A8T
415: Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Sekulovski S, Devant P, Panizza S, Gogakos T, Pitiriciu A, Heitmeier K, Ramsay EP, Barth M, Schmidt C, Tuschl T, Baas F, Weitzer S, Martinez J, Trowitzsch S.
Nat Commun. 2021 Sep 28;12(1):5610.
DOI: 10.1038/s41467-021-25870-3 |
PUBMED: 34584079 | IF(2022) = 14.9
PDB [P14]: 6Z9U
414: Low Carbon Footprint Recycling of Post-Consumer PET Plastic with a Metagenomic Polyester Hydrolase.
Sonnendecker C, Oeser J, Richter PK, Hille P, Zhao Z, Fischer C, Lippold H, Blázquez-Sánchez P, Engelberger F, Ramírez-Sarmiento CA, Oeser T, Lihanova Y, Frank R, Jahnke HG, Billig S, Abel B, Sträter N, Matysik J, Zimmermann W.
ChemSusChem. (2021 Jun)UNK:pp. UNK
DOI: 10.1002/cssc.202101062 |
PUBMED: 34129279 | IF(2019) = 7.692
PDB [P14]: 7NEI
413: Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
Nguyen D, Xie X, Jakobi S, Terwesten F, Metz A, Nguyen TXP, Palchykov VA, Heine A, Reuter K, Klebe G.
ACS Chem Biol. (2021 Jun)16:1090-1098
DOI: 10.1021/acschembio.1c00296 |
PUBMED: 34081441 | IF(2019) = 4.43
PDB [P13P14]: 7A4X 7ADN
412: A simple vapor-diffusion method enables protein crystallization inside the HARE serial crystallography chip.
Norton-Baker B, Mehrabi P, Boger J, Schönherr R, von Stetten D, Schikora H, Kwok AO, Martin RW, Miller RJD, Redecke L, Schulz EC.
Acta Crystallogr D Struct Biol. (2021 Jun)77:820-834
DOI: 10.1107/s2059798321003855 |
PUBMED: 34076595 | IF(2018) = 3.2
PDB [P14]: 7NJH 7NJG 7NJJ 7NJI 7NJE 7NKF 7NJF
411: Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum.
Švecová L, Østergaard LH, Skálová T, Schnorr KM, Koval' T, Kolenko P, Stránský J, Sedlák D, Dušková J, Trundová M, Hašek J, Dohnálek J.
Acta Crystallogr D Struct Biol. (2021 Jun)77:755-775
DOI: 10.1107/s2059798321003533 |
PUBMED: 34076590 | IF(2018) = 3.2
PDB [P13]: 7AA2 6ZE5 6ZE2
410: Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent.
Narczyk M, Mioduszewski Ł, Oksiejuk A, Winiewska-Szajewska M, Wielgus-Kutrowska B, Gojdź A, Cieśla J, Bzowska A.
Sci Rep. (2021 May)11:11144
DOI: 10.1038/s41598-021-90472-4 |
PUBMED: 34045551 | IF(2022) = 5.0
PDB [P14]: 6XZ2
409: Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.
Yperman K, Papageorgiou AC, Merceron R, De Munck S, Bloch Y, Eeckhout D, Jiang Q, Tack P, Grigoryan R, Evangelidis T, Van Leene J, Vincze L, Vandenabeele P, Vanhaecke F, Potocký M, De Jaeger G, Savvides SN, Tripsianes K, Pleskot R, Van Damme D.
Nat Commun. (2021 May)12:3050
DOI: 10.1038/s41467-021-23314-6 |
PUBMED: 34031427 | IF(2022) = 14.9
PDB [P14]: 6YIG
408: TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D.
Mol Cell. (2021 Apr)UNK:pp. UNK
DOI: 10.1016/j.molcel.2021.04.019 |
PUBMED: 33974911 | IF(2018) = 14.5
PDB [P13]: 7A0N
407: Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Wurm JP, Sung S, Kneuttinger AC, Hupfeld E, Sterner R, Wilmanns M, Sprangers R.
Nat Commun. (2021 May)12:2748
DOI: 10.1038/s41467-021-22968-6 |
PUBMED: 33980881 | IF(2022) = 14.9
PDB [P13]: 7AC8
406: A lysine-cysteine redox switch with an NOS bridge regulates enzyme function.
Wensien M, von Pappenheim FR, Funk LM, Kloskowski P, Curth U, Diederichsen U, Uranga J, Ye J, Fang P, Pan KT, Urlaub H, Mata RA, Sautner V, Tittmann K.
Nature. 2021 May;593(7859):460-464. Epub 2021 May 5.
DOI: 10.1038/s41586-021-03513-3 |
PUBMED: 33953398 | IF(2018) = 43.1
PDB [P14]: 6ZWJ 7BBW 7BBX 6ZWF 6ZX4 6ZWH
405: The crystal structure of the Ca2+-ATPase 1 from Listeria monocytogenes reveals a pump primed for dephosphorylation.
Basse Hansen S, Dyla M, Neumann C, Meldgaard Hoegh Quistgaard E, Lauwring Andersen J, Kjaergaard M, Nissen P.
J Mol Biol. (2021 Apr)UNK:167015
DOI: 10.1016/j.jmb.2021.167015 |
PUBMED: 33933469 | IF(2018) = 5.1
PDB [P13]: 6ZHH 6ZHG
404: The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan.
Imae R, Kuwabara N, Manya H, Tanaka T, Tsuyuguchi M, Mizuno M, Endo T, Kato R.
Genes Cells. (2021 Apr)UNK:pp. UNK
DOI: 10.1111/gtc.12853 |
PUBMED: 33893702 | IF(2019) = 1.65
PDB [P14]: 7E9K
403: Serendipitous crystallization of E. coli HPII catalase, a sequel to "the tale usually not told".
Grzechowiak M, Sekula B, Jaskolski M, Ruszkowski M.
Acta Biochim Pol. (2021 Jan) 68:29-31
DOI: 10.18388/abp.2020_5501 |
PUBMED: 33485289
PDB [P13]: 6ZTV 6ZTW
402: X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schluenzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A.
Science. (2021 May 7) 372(6542):642-646
DOI: 10.1126/science.abf7945 |
PUBMED: 33811162 | IF(2018) = 41.1
PDB [P14]: 7AXO
401: Crystal structures of the EVE-HNH endonuclease VcaM4I in the presence and absence of DNA.
Pastor M, Czapinska H, Helbrecht I, Krakowska K, Lutz T, Xu SY, Bochtler M.
Nucleic Acids Res. (2021 Feb)49:1708-1723
DOI: 10.1093/nar/gkaa1218 |
PUBMED: 33450012 | IF(2018) = 11.1
PDB [P13]: 6YKF
400: The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins.
Röllen K, Granzin J, Remeeva A, Davari MD, Gensch T, Nazarenko VV, Kovalev K, Bogorodskiy A, Borshchevskiy V, Hemmer S, Schwaneberg U, Gordeliy V, Jaeger KE, Batra-Safferling R, Gushchin I, Krauss U.
J Biol Chem. (2021 Apr)UNK:100662
DOI: 10.1016/j.jbc.2021.100662 |
PUBMED: 33862085 | IF(2018) = 4.1
PDB [P13P14]: 7AB7
399: Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison.
Mehrabi P, Bücker R, Bourenkov G, Ginn HM, von Stetten D, Müller-Werkmeister HM, Kuo A, Morizumi T, Eger BT, Ou WL, Oghbaey S, Sarracini A, Besaw JE, Pare-Labrosse O, Meier S, Schikora H, Tellkamp F, Marx A, Sherrell DA, Axford D, Owen RL, Ernst OP, Pai EF, Schulz EC, Miller RJD.
Sci Adv. (2021 Mar 17) 7(12):eabf1380
DOI: 10.1126/sciadv.abf1380 |
PUBMED: 33731353 | IF(2018) = 12.5
PDB [P14]: 7A42 7A44
398: Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.
Sutherland M, Li A, Kaghad A, Panagopoulos D, Li F, Szewczyk M, Smil D, Scholten C, Bouché L, Stellfeld T, Arrowsmith CH, Barsyte D, Vedadi M, Hartung IV, Steuber H, Britton R, Santhakumar V.
ChemMedChem. (2021 Apr)16:1116-1125
DOI: 10.1002/cmdc.202100018 |
PUBMED: 33513288 | IF(2018) = 3.0
PDB [P13]: 7NR4
397: Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII.
Smirnovienė J, Smirnov A, Zakšauskas A, Zubrienė A, Petrauskas V, Mickevičiūtė A, Michailovienė V, Čapkauskaitė E, Manakova E, Gražulis S, Baranauskienė L, Chen WY, Ladbury JE, Matulis D.
ChemistryOpen (2021 May)10:567-580
DOI: 10.1002/open.202100042 |
PUBMED: 33945229
PDB [P13]: 6YH6 6YH8 6YHB 6YH5 6YH7 6YH9 6YHA 6YH4 6YHC
396: Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors.
Bauder M, Meyners C, Purder PL, Merz S, Sugiarto WO, Voll AM, Heymann T, Hausch F.
J Med Chem. (2021 Mar)64:3320-3349
DOI: 10.1021/acs.jmedchem.0c02195 |
PUBMED: 33666419 | IF(2018) = 6.1
PDB [P13]: 7B9Z 7B9Y 7BA0
395: Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A.
J Med Chem. (2021 Apr)64:4623-4661
DOI: 10.1021/acs.jmedchem.0c02094 |
PUBMED: 33818106 | IF(2018) = 6.1
PDB [P13P14]: 6ZF4 6ZF5 6ZF7 6ZF0 6ZF1 6ZF2 6ZF3 6ZF6
394: Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism.
Bustad HJ, Kallio JP, Laitaoja M, Toska K, Kursula I, Martinez A, Jänis J.
iScience. (2021 Mar)24:102152
DOI: 10.1016/j.isci.2021.102152 |
PUBMED: 33665570 | IF(2020) = 4
PDB [P13P14]: 7AAJ 7AAK
393: Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Pannecoucke E, Van Trimpont M, Desmet J, Pieters T, Reunes L, Demoen L, Vuylsteke M, Loverix S, Vandenbroucke K, Alard P, Henderikx P, Deroo S, Baatz F, Lorent E, Thiolloy S, Somers K, McGrath Y, Van Vlierberghe P, Lasters I, Savvides SN.
Sci Adv. (2021 Mar)7:pp. UNK
DOI: 10.1126/sciadv.abe1682 |
PUBMED: 33771865 | IF(2018) = 12.5
PDB [P14]: 6ZL1
392: Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP.
Shaikhqasem A, Schmitt K, Valerius O, Ficner R.
Acta Crystallogr F Struct Biol Commun. (2021 Mar)77:70-78
DOI: 10.1107/s2053230x2100203x |
PUBMED: 33682791 | IF(2019) = 0.97
PDB [P13]: 7B51
391: Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1.
Ruegenberg S, Mayr FAMC, Atanassov I, Baumann U, Denzel MS.
Nat Commun. (2021 Apr)12:2176
DOI: 10.1038/s41467-021-22320-y |
PUBMED: 33846315 | IF(2022) = 14.9
PDB [P13]: 6ZMK 7NDL
390: Structural insights into the inhibition of glycine reuptake.
Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR, Dawson RJP, Nissen P.
Nature (2021 Mar)591:677-681
DOI: 10.1038/s41586-021-03274-z |
PUBMED: 33658720 | IF(2018) = 43.1
PDB [P14]: 6ZPL 6ZBV
389: The structure of Prp2 bound to RNA and ADP-BeF3- reveals structural features important for RNA unwinding by DEAH-box ATPases.
Hamann F, Zimmerningkat LC, Becker RA, Garbers TB, Neumann P, Hub JS, Ficner R.
Acta Crystallogr D Struct Biol. (2021 Apr)77:496-509
DOI: 10.1107/s2059798321001194 |
PUBMED: 33825710 | IF(2018) = 3.2
PDB [P14]: 6ZM2
388: Arresting the Catalytic Arginine in Chlorite Dismutases: Impact on Heme Coordination, Thermal Stability, and Catalysis.
Schmidt D, Serra I, Mlynek G, Pfanzagl V, Hofbauer S, Furtmüller PG, Djinović-Carugo K, Van Doorslaer S, Obinger C.
Biochemistry (2021 Mar) 60:621-634
DOI: 10.1021/acs.biochem.0c00910 |
PUBMED: 33586945 | IF(2018) = 3.0
PDB [P13]: 7ASB 7ATI
387: Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue.
Arkhipova V, Fu H, Hoorens MWH, Trinco G, Lameijer LN, Marin E, Feringa BL, Poelarends GJ, Szymanski W, Slotboom DJ, Guskov A.
J Am Chem Soc. (2021 Jan)143:1513-1520
DOI: 10.1021/jacs.0c11336 |
PUBMED: 33449695 | IF(2018) = 14.7
PDB [P13]: 6ZLH 6ZGB 6ZL4
386: Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production.
Venskutonytė R, Koh A, Stenström O, Khan MT, Lundqvist A, Akke M, Bäckhed F, Lindkvist-Petersson K.
Nat Commun. (2021 Mar)12:1347
DOI: 10.1038/s41467-021-21548-y |
PUBMED: 33649331 | IF(2022) = 14.9
PDB [P13]: 6T85
385: Structural basis of Naa20 activity towards a canonical NatB substrate.
Layer D, Kopp J, Fontanillo M, Köhn M, Lapouge K, Sinning I.
Commun Biol. 2021 Jan 4;4(1):2.
DOI: 10.1038/s42003-020-01546-4. |
PUBMED: 33398031 | IF(2019) = 12.1
PDB [P14]: 6ZMP
384: Structural properties and peptide ligand binding of the capsid homology domains of human Arc.
Hallin EI, Bramham CR, Kursula P.
Biochem Biophys Rep. (2021 Jul)26:100975
DOI: 10.1016/j.bbrep.2021.100975 |
PUBMED: 33732907 | IF(2021) = 2.53
PDB [P13P14]: 6TQ0 6TNO 6TN7 6TNQ
383: The amphibian antimicrobial peptide uperin 3.5 is a cross-α/cross-β chameleon functional amyloid
Salinas N, Tayeb-Fligelman E, Sammito MD, Bloch D, Jelinek R, Noy D, Usón I, Landau M
Proc Natl Acad Sci U S A. 118(3):e2014442118.
DOI: 10.1073/pnas.2014442118 |
PUBMED: 33431675 | IF(2019) = 9.4
PDB [P14]:
382: The copper(II)-binding tripeptide GHK, a valuable crystallization and phasing tag for macromolecular crystallography.
Mehr A, Henneberg F, Chari A, Görlich D, Huyton T.
Acta Crystallogr D Struct Biol. 2020 Dec 1;76(Pt 12):1222-1232.
DOI: 10.1107/S2059798320013741. |
PUBMED: 33263328 | IF(2018) = 3.2
PDB [P14]:
381: RIM-binding protein couples synaptic vesicle recruitment to release sites.
Petzoldt AG, Götz TWB, Driller JH, Lützkendorf J, Reddy-Alla S, Matkovic-Rachid T, Liu S, Knoche E, Mertel S, Ugorets V, Lehmann M, Ramesh N, Beuschel CB, Kuropka B, Freund C, Stelzl U, Loll B, Liu F, Wahl MC, Sigrist SJ.
J Cell Biol. 2020 Jul 6;219(7):e201902059.
DOI: 10.1083/jcb.201902059. |
PUBMED: 32369542 | IF(2018) = 8.8
PDB [P14]:
380: Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation.
Kisiala M, Kowalska M, Pastor M, Korza HJ, Czapinska H, Bochtler M.
Nucleic Acids Res. 2020 Jul 9;48(12):6954-6969.
DOI: 10.1093/nar/gkaa403. |
PUBMED: 32459314 | IF(2018) = 11.1
PDB [P13]: 6G3B
379: C60 in a peptidic cage: a case of symmetry mismatch studied by crystallography and solid-state NMR.
Gilski M, Bernatowicz P, Sakowicz A, Szymański MP, Zalewska A, Szumna A, Jaskólski M
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2020 Oct 1;76(Pt 5):815-824.
DOI: 10.1107/S2052520620009944. |
PUBMED: 33017315
PDB [P13]:
378: Aromatic Foldamer Helices as α-Helix Extended Surface Mimetics.
Zwillinger M, Reddy PS, Wicher B, Mandal PK, Csékei M, Fischer L, Kotschy A, Huc I.
Chemistry. 2020 Dec 23;26(72):17366-17370.
DOI: 10.1002/chem.202004064. Epub 2020 Nov 30. |
PUBMED: 32910480 | IF(2019) = 4.9
PDB [P13]:
377: Serial synchrotron crystallography for time-resolved structural biology.
Pearson AR, Mehrabi P.
Curr Opin Struct Biol. 2020 Dec;65:168-174.
DOI: 10.1016/j.sbi.2020.06.019. |
PUBMED: 32846363.
PDB [P14]:
376: The HARE chip for efficient time-resolved serial synchrotron crystallography.
Mehrabi P, Müller-Werkmeister HM, Leimkohl JP, Schikora H, Ninkovic J, Krivokuca S, Andriček L, Epp SW, Sherrell D, Owen RL, Pearson AR, Tellkamp F, Schulz EC, Miller RJD.
J Synchrotron Radiat. 2020 Mar 1;27(Pt 2):360-370.
DOI: 10.1107/S1600577520000685. |
PUBMED: 32153274
PDB [P14]:
375: Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif.
Eriksen MS, Nikolaienko O, Hallin EI, Grødem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuéllar J, Chambers JJ, O'Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A, Bramham CR.
FEBS J. (2020 Nov)UNK:pp. UNK
DOI: 10.1111/febs.15618 |
PUBMED: 33175445 | IF(2018) = 4.7
PDB [P13]: 6YTU
374: Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I.
Cell Chem Biol. (2020 Nov)27:1441-1451.e7
DOI: 10.1016/j.chembiol.2020.07.010 |
PUBMED: 32726587
PDB [P13]: 6YEK
373: Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7.
Hanke S, Tindall CA, Pippel J, Ulbricht D, Pirotte B, Reboud-Ravaux M, Heiker JT, Sträter N.
J Med Chem. 2020 Jun 11;63(11):5723-5733.
DOI: 10.1021/acs.jmedchem.9b01806 |
PUBMED: 32374603 | IF(2018) = 6.1
PDB [P14]:
372: Development of PSMA-1007-Related Series of 18F-Labeled Glu-Ureido-Type PSMA Inhibitors.
Cardinale J, Roscher M, Schäfer M, Geerlings M, Benešová Bauder-Wüst U, Remde Y, Eder M, Nováková Z, Motlová L, Barinka C, Giesel FL, Kopka K.
J Med Chem. 2020 Oct 8;63(19):10897-10907.
DOI: 10.1021/acs.jmedchem.9b01479 |
PUBMED: 32852205 | IF(2018) = 6.1
PDB [P13]: 5O5T
371: Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Weidenhausen J, Kopp J, Armbruster L, Wirtz M, Lapouge K, Sinning I.
Structure. (2020 Dec)UNK:pp. UNK
DOI: 10.1016/j.str.2020.12.004 |
PUBMED: 33400917 | IF(2022) = 5.0
PDB [P13]: 6Z00
370: High-resolution structural insights into the heliorhodopsin family.
Kovalev K, Volkov D, Astashkin R, Alekseev A, Gushchin I, Haro-Moreno JM, Chizhov I, Siletsky S, Mamedov M, Rogachev A, Balandin T, Borshchevskiy V, Popov A, Bourenkov G, Bamberg E, Rodriguez-Valera F, Büldt G, Gordeliy V.
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4131-4141.
DOI: 10.1073/pnas.1915888117 |
PUBMED: 32034096 | IF(2019) = 9.4
PDB [P14]:
369: Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.
Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C.
Nat Commun. 2020 Jan 23;11(1):440.
DOI: 10.1038/s41467-020-14343-8 |
PUBMED: 31974402 | IF(2022) = 14.9
PDB [P14]:
368: Ctf18-RFC and DNA Pol ϵ form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication.
Stokes K, Winczura A, Song B, Piccoli G, Grabarczyk DB.
Nucleic Acids Res. (2020 Aug)48:8128-8145
DOI: 10.1093/nar/gkaa541 |
PUBMED: 32585006 | IF(2018) = 11.1
PDB [P13]: 6S1C
367: A Proline-Rich Element in the Type III Secretion Protein FlhB Contributes to Flagellar Biogenesis in the Beta- and Gamma-Proteobacteria.
Hook JC, Blagotinsek V, Pané-Farré J, Mrusek D, Altegoer F, Dornes A, Schwan M, Schier L, Thormann KM, Bange G.
Front Microbiol. (2020 )11:564161
DOI: 10.3389/fmicb.2020.564161 |
PUBMED: 33384667 | IF(2019) = 4.2
PDB [P13]: 6Z0W
366: Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and Pi Release.
Franz P, Ewert W, Preller M, Tsiavaliaris G.
Int J Mol Sci. (2020 Dec) 22:104
DOI: 10.3390/ijms22010104 |
PUBMED: 33374308 | IF(2018) = 4.2
PDB [P13]: 7B1A
365: The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action.
Weikum J, Kulakova A, Tesei G, Yoshimoto S, Jægerum LV, Schütz M, Hori K, Skepö M, Harris P, Leo Morth JP
Sci Rep. 2020 Dec 4;10(1):21249.
DOI: 10.1038/s41598-020-77706-7 |
PUBMED: 33277518 | IF(2022) = 5.0
PDB [P13P14]: 6TQD 6TPL
364: HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation.
Songailiene I, Juozapaitis J, Tamulaitiene G, Ruksenaite A, Šulčius S, Sasnauskas G, Venclovas Č, Siksnys V.
Mol Cell. (2020 Dec)80:955-970.e7
DOI: 10.1016/j.molcel.2020.11.034 |
PUBMED: 33290744 | IF(2018) = 14.5
PDB [P13]: 7AE6 7AE8 7AE9 7AE2
363: Diamond refractive micro-lenses for full-field X-ray imaging and microscopy produced with ion beam lithography.
Medvedskaya, P., Lyatun, I., Shevyrtalov, S., Polikarpov, M., Snigireva, I., Yunkin, V., & Snigirev, A.
Optics express. 28(4), 4773-S785.
DOI: 10.1364/OE.384647 |
PUBMED: 32121709 | IF(2019) = 3.67
PDB [P14]:
362: Crystal structures of a novel family IV esterase in free and substrate-bound form.
Höppner A, Bollinger A, Kobus S, Thies S, Coscolín C, Ferrer M, Jaeger KE, Smits SHJ.
FEBS J. (2020 Dec) UNK:pp. UNK
DOI: 10.1111/febs.15680 |
PUBMED: 33342083 | IF(2018) = 4.7
PDB [P14]: 6Z68
361: Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis.
Kozak S, Bloch Y, De Munck S, Mikula A, Bento I, Savvides SN, Meijers R.
Acta Crystallogr D Struct Biol (2020 Dec)76:1244-1255
DOI: 10.1107/s2059798320013753 |
PUBMED: 33263330 | IF(2018) = 3.2
PDB [P13P14]: 6ZR7 6SFF
360: Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.
Myllykoski M, Sutinen A, Koski MK, Kallio JP, Raasakka A, Myllyharju J, Wierenga RK, Koivunen P.
J Biol Chem. (2020 Dec)UNK:pp. UNK
DOI: 10.1074/jbc.ra120.016542 |
PUBMED: 33334883 | IF(2018) = 4.1
PDB [P13]: 6TP5
359: Inhibition of urease, a Ni-enzyme: the reactivity of a key thiol with mono- and di-substituted catechols elucidated by kinetic, structural and theoretical studies.
Mazzei L, Contaldo U, Musiani F, Cianci M, Bagnolini G, Roberti M, Ciurli S.
Angew Chem Int Ed Engl. (2020 Nov)UNK:pp. UNK
DOI: 10.1002/anie.202014706 |
PUBMED: 33245574 | IF(2019) = 13.0
PDB [P13]: 6ZNY 6ZNZ 6ZO1
358: Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms.
Chaikuad A, Pollinger J, Rühl M, Ni X, Kilu W, Heering J, Merk D.
Int J Mol Sci (2020 Nov)21:pp. UNK
DOI: 10.3390/ijms21228457 |
PUBMED: 33187070
PDB [P13]: 7A77
357: Structural and functional characterization of the glutathione peroxidase-like thioredoxin peroxidase from the fungus Trichoderma reesei.
Adriani PP, de Paiva FCR, de Oliveira GS, Leite AC, Sanches AS, Lopes AR, Dias MVB, Chambergo FS.
Int J Biol Macromol (2020 Nov)167:93-100
DOI: 10.1016/j.ijbiomac.2020.11.179 |
PUBMED: 33259843 | IF(2018) = 4.8
PDB [P13]: 6VPD
356: Phi class glutathione transferases as molecular targets towards multiple-herbicide resistance: Inhibition analysis and pharmacophore design.
Georgakis N, Poudel N, Vlachakis D, Papageorgiou AC, Labrou NE.
Plant Physiol Biochem. (2020 Nov)UNK:pp. UNK
DOI: 10.1016/j.plaphy.2020.11.018 |
PUBMED: 33257232 | IF(2019) = 3.72
PDB [P14]: 6ZB6
355: Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B.
J Med Chem. (2020 Nov)63:13709-13718
DOI: 10.1021/acs.jmedchem.0c01202 |
PUBMED: 33143415 | IF(2018) = 6.1
PDB [P13]: 6ZFM
354: Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection.
Anjanappa R, Garcia-Alai M, Kopicki JD, Lockhauserbäumer J, Aboelmagd M, Hinrichs J, Nemtanu IM, Uetrecht C, Zacharias M, Springer S, Meijers R.
Nat Commun. (2020 Mar)11:1314
DOI: 10.1038/s41467-020-14862-4 |
PUBMED: 32161266 | IF(2022) = 14.9
PDB [P14]: 6TDP 6TDO 6TDQ 6TDS 6TDR
353: Exposing the distinctive modular behavior of β-strands and α-helices in folded proteins.
Wang H, Logan DT, Danielsson J, Oliveberg M.
Proc Natl Acad Sci U S A. (2020 Nov) 117:28775-28783
DOI: 10.1073/pnas.1920455117 |
PUBMED: 33148805 | IF(2019) = 9.4
PDB [P14]: 6I6E 6I69 6I6I 6I6O
352: Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter.
Normant V, Josts I, Kuhn L, Perraud Q, Fritsch S, Hammann P, Mislin GLA, Tidow H, Schalk IJ.
ACS Chem Biol. (2020 Oct)15:2741-2751
DOI: 10.1021/acschembio.0c00535 |
PUBMED: 32902248 | IF(2019) = 4.43
PDB [P14]: 6Z8A
351: Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode.
Drakou CE, Gardeli C, Tsialtas I, Alexopoulos S, Mallouchos A, Koulas SM, Tsagkarakou AS, Asimakopoulos D, Leonidas DD, Psarra AG, Skamnaki VT.
J Agric Food Chem (2020 Sep)68:10191-10199
DOI: 10.1021/acs.jafc.0c04205 |
PUBMED: 32840370
PDB [P13]: 6YVE
350: Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Kirsch K, Zeke A, Tőke O, Sok P, Sethi A, Sebő A, Kumar GS, Egri P, Póti ÁL, Gooley P, Peti W, Bento I, Alexa A, Reményi A.
Nat Commun. (2020 Nov)11:5769
DOI: 10.1038/s41467-020-19582-3 |
PUBMED: 33188182 | IF(2022) = 14.9
PDB [P13P14]: 6ZQS 6ZR5
349: A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
Stefano JE, Lord DM, Zhou Y, Jaworski J, Hopke J, Travaline T, Zhang N, Wong K, Lennon A, He T, Bric-Furlong E, Cherrie C, Magnay T, Remy E, Brondyk W, Qiu H, Radošević K.
J Biol Chem. (2020 Oct)UNK:pp. UNK
DOI: 10.1074/jbc.ra120.012395 |
PUBMED: 33122192 | IF(2018) = 4.1
PDB [P14]: 6VC9
348: Gas channel rerouting in a primordial enzyme: Structural insights of the carbon-monoxide dehydrogenase/acetyl-CoA synthase complex from the acetogen Clostridium autoethanogenum.
Lemaire ON, Wagner T.
Biochim Biophys Acta Bioenerg. (2020 Oct)1862:148330
DOI: 10.1016/j.bbabio.2020.148330 |
PUBMED: 33080205
PDB [P13]: 6YTT
347: Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.
Liess AKL, Kucerova A, Schweimer K, Schlesinger D, Dybkov O, Urlaub H, Mansfeld J, Lorenz S.
Sci Signal. (2020 Oct)13:pp. UNK
DOI: 10.1126/scisignal.aba8208 |
PUBMED: 33082289 | IF(2019) = 4.9
PDB [P13]: 6S96
346: Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System.
Bertelsen MB, Senissar M, Nielsen MH, Bisiak F, Cunha MV, Molinaro AL, Daines DA, Brodersen DE.
Structure. (2020 Oct)UNK:pp. UNK
DOI: 10.1016/j.str.2020.10.002 |
PUBMED: 33096014 | IF(2022) = 5.0
PDB [P13]: 6ZI0 6ZI1
345: Structural role of essential light chains in the apicomplexan glideosome.
Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Löw C.
Commun Biol. (2020 Oct)3:568
DOI: 10.1038/s42003-020-01283-8 |
PUBMED: 33051581 | IF(2019) = 12.1
PDB [P13]: 6ZN3 6TJ4 6TJ5 6TJ6 6TJ7
344: Structural basis for inhibition of an archaeal CRISPR-Cas type I-D large subunit by an anti-CRISPR protein.
Manav MC, Van LB, Lin J, Fuglsang A, Peng X, Brodersen DE.
Nat Commun. (2020 Nov)11:5993
DOI: 10.1038/s41467-020-19847-x |
PUBMED: 33239638 | IF(2022) = 14.9
PDB [P14]: 6THH
343: Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions.
Michailidou F, Klöcker N, Cornelissen N, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A.
Angew Chem Int Ed Engl. (2020 Oct)UNK:pp. UNK
DOI: 10.1002/anie.202012623 |
PUBMED: 33017502 | IF(2019) = 13.0
PDB [P13]: 6LTV 6LTW
342: Rational design of balanced dual-targeting antibiotics with limited resistance.
Nyerges A, Tomaš T, Durcik M, Revesz T, Szili P, Draskovits G, Bogar F, Skok Ž, Zidar N, Ilaš J, Zega A, Kikelj D, Daruka L, Kintses B, Vasarhelyi B, Foldesi I, Kata D, Welin M, Kimbung R, Focht D, Mašič LP, Pal C.
PLoS Biol. 2020 Oct 5;18(10):e3000819.
DOI: 10.1371/journal.pbio.3000819. |
PUBMED: 33017402 | IF(2018) = 8.4
PDB [P13]: 6TCK
341: Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle.
Dudutiene V, Zubriene A, Kairys V, Smirnov A, Smirnovien J, Leitans J, Kazaks A, Tars K, Manakova L, Gražulis S, Matulis D.
Biophys J (2020 Sep)UNK:pp. UNK
DOI: 10.1016/j.bpj.2020.08.037 |
PUBMED: 32971003
PDB [P13P14]: 6T4N 6T4O 6T81 6T5Q 6T5P 6T5C
340: High-resolution crystal structure and biochemical characterization of a GH11 endoxylanase from Nectria haematococca.
Andaleeb H, Ullah N, Falke S, Perbandt M, Brognaro H, Betzel C.
Sci Rep. (2020 Sep)10:15658
DOI: 10.1038/s41598-020-72644-w |
PUBMED: 32973265 | IF(2022) = 5.0
PDB [P13]: 6Y0H
339: Anomeric Selectivity of Trehalose Transferase with Rare l-Sugars.
Mestrom L, Marsden SR, van der Eijk H, Laustsen JU, Jeffries CM, Svergun DI, Hagedoorn PL, Bento I, Hanefeld U.
ACS Catalysis. (2020 Aug)10:8835-8839
DOI: 10.1021/acscatal.0c02117 |
PUBMED: 32953231 | IF(2018) = 12.1
PDB [P13]: 6ZJ4 6ZJ7 6ZMZ 6ZJH 6ZN1
338: Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.
Mokrushina YA, Golovin AV, Smirnov IV, Chatziefthimiou SD, Stepanova AV, Bobik TV, Zalevsky AO, Zlobin AS, Konovalov KA, Terekhov SS, Stepanov AV, Pipiya SO, Shamborant OG, Round E, Belogurov AA, Bourenkov G, Makarov AA, Wilmanns M, Xie J, Blackburn GM, Gabibov AG, Lerner RA.
Proc Natl Acad Sci U S A. (2020 Aug) UNK:pp. UNK
DOI: 10.1073/pnas.2010317117 |
PUBMED: 32859757 | IF(2019) = 9.4
PDB [P13P14]: 6Y49 6Y1M 6Y1K 6Y1L
337: Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions.
Stalmans G, Lilina AV, Vermeire PJ, Fiala J, Novák P, Strelkov SV.
Cells. (2020 Jul) 9:pp. UNK
DOI: 10.3390/cells9071633 |
PUBMED: 32645958 | IF(2019) = 4.4
PDB [-P14]: 6YSH
336: Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A.
Fiebig T, Cramer JT, Bethe A, Baruch P, Curth U, Führing JI, Buettner FFR, Vogel U, Schubert M, Fedorov R, Mühlenhoff M.
Nat Commun. (2020 Sep)11:4723
DOI: 10.1038/s41467-020-18464-y |
PUBMED: 32948778 | IF(2022) = 14.9
PDB [P13P14]: 6YUS 6YUQ
335: Structural and Functional Characterization of NadR from Lactococcus lactis.
Stetsenko A, Singh R, Jaehme M, Guskov A, Slotboom DJ.
Molecules. (2020 Apr) 25:pp. UNK
DOI: 10.3390/molecules25081940 |
PUBMED: 32331317 | IF(2020) = 3.3
PDB [P13]: 6GYF 6GZO
334: Structural and biochemical characterization of a family 7 highly thermostable endoglucanase from the fungus Rasamsonia emersonii.
Schiano-di-Cola C, Kołaczkowski B, Sørensen TH, Christensen SJ, Cavaleiro AM, Windahl MS, Borch K, Morth JP, Westh P.
FEBS J. (2020 Jun) 287:2577-2596
DOI: 10.1111/febs.15151 |
PUBMED: 31755197 | IF(2018) = 4.7
PDB [P14]: 6SU8
333: Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S.
J Med Chem. (2020 Jul) 63:6784-6801
DOI: 10.1021/acs.jmedchem.9b01803 |
PUBMED: 32433887 | IF(2018) = 6.1
PDB [P13]: 6T29
332: Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis.
Meyer T, Zumbrägel N, Geerds C, Gröger H, Niemann HH.
Biomolecules (2020 Jul) 10:pp. UNK
DOI: OI: 10.3390/biom10081130 |
PUBMED: 32751900
PDB [P13]: 6SMT
331: The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure.
Engelberg Y, Landau M
Nat Commun. (2020 Aug 4) 11(1):3894.
DOI: 10.1038/s41467-020-17736-x |
PUBMED: 32753597 | IF(2022) = 14.9
PDB [P14]: 6S6M
330: Sjogren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells.
Perdreau-Dahl H, Progida C, Barfeld SJ, Guldsten H, Thiede B, Arntzen M, Bakke O, Mills IG, Krauss S, Morth JP
Commun Biol. (2020 Mar 13) 3(1):123.
DOI: 10.1038/s42003-020-0851-2 |
PUBMED: 32170109 | IF(2019) = 12.1
PDB [P13]: 6HCZ
329: Molecular mechanism of light-driven sodium pumping.
Kovalev K, Astashkin R, Gushchin I, Orekhov P, Volkov D, Zinovev E, Marin E, Rulev M, Alekseev A, Royant A, Carpentier P, Vaganova S, Zabelskii D, Baeken C, Sergeev I, Balandin T, Bourenkov G, Carpena X, Boer R, Maliar N, Borshchevskiy V, Buldt G, Bamberg E, Gordeliy V
Nat Commun. (2020 May 1) 11(1):2137.
DOI: 10.1038/s41467-020-16032-y |
PUBMED: 32358514 | IF(2022) = 14.9
PDB [P14]: 6YC2 6YC3 6YC4
328: Structure-based design approach to rational site-directed mutagenesis ofbeta-lactoglobulin.
Bonarek P, Loch JI, Tworzydlo M, Cooper DR, Milto K, Wrobel P, Kurpiewska K, Lewinski K
J Struct Biol. (2020 May 1) 210(2):107493.
DOI: 10.1016/j.jsb.2020.107493 |
PUBMED: 32169624 | IF(2018) = 3.8
PDB [P13]: 6RYT
327: Structural Studies of Glutamate Dehydrogenase (Isoform 1) From Arabidopsisthaliana, an Important Enzyme at the Branch-Point Between Carbon and NitrogenMetabolism.
Grzechwiak M, Sliwiak J, Jaskolski M, Ruszkowski M
Front Plant Sci. 2020 Jun 5;11:754.
DOI: 10.3389/fpls.2020.00754 |
PUBMED: 32655590 | IF(2016) = 4.4
PDB [P13]: 6YEI 6YEH
326: Architecture and functional dynamics of the pentafunctional AROM complex.
Arora Veraszto H, Logotheti M, Albrecht R, Leitner A, Zhu H, Hartmann MD,
Nat Chem Biol. 2020 Jul 6.
DOI: 10.1038/s41589-020-0587-9 |
PUBMED: 32632294 | IF(2020) = 41.8
PDB [P14]: 6HQV
325: Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.
Grabarczyk DB,
Nucleic Acids Res. 2020 Jul 9;48(12):6996-7004.
DOI: 10.1093/nar/gkaa456 |
PUBMED: 32469068 | IF(2018) = 11.1
PDB [P14]: 6XWX
324: Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA.
Szewczyk M, Malik D, Borowski LS, Czarnomska SD, Kotrys AV, Klosowska-Kosicka K, Nowotny M, Szczesny RJ,
Nucleic Acids Res. 2020 Jun 4;48(10):5572-5590.
DOI: 10.1093/nar/gkaa302 |
PUBMED: 32365187 | IF(2018) = 11.1
PDB [P13]: 6STY
323: Structural basis for antibiotic action of the B1 antivitamin 2'-methoxy-thiamine.
Rabe von Pappenheim F, Aldeghi M, Shome B, Begley T, de Groot BL, Tittmann K.
Nat Chem Biol. (2020 Aug) UNK:pp. UNK
DOI: 10.1038/s41589-020-0628-4 |
PUBMED: 32839604 | IF(2020) = 41.8
PDB [P14]: 6TJ8 6TJ9
322: Structural signatures in EPR3 define a unique class of plant carbohydrate receptors.
Wong JEMM, Gysel K, Birkefeldt TG, Vinther M, Muszyński A, Azadi P, Laursen NS, Sullivan JT, Ronson CW, Stougaard J, Andersen KR.
Nat Commun. (2020 Jul)11:3797
DOI: 10.1038/s41467-020-17568-9 |
PUBMED: 32732998 | IF(2022) = 14.9
PDB [P14]: 6QUP
321: Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System.
Laursen NS, Pedersen DV, Gytz H, Zarantonello A, Bernth Jensen JM, Hansen AG, Thiel S, Andersen GR.
Front Immunol. (2020 )11:1504
DOI: 10.3389/fimmu.2020.01504 |
PUBMED: 32849513 | IF(2018) = 6.4
PDB [P14]: 6Z6V
320: A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Picado A, Chaikuad A, Wells CI, Shrestha S, Zuercher WJ, Pickett JE, Kwarcinski FE, Sinha P, de Silva CS, Zutshi R, Liu S, Kannan N, Knapp S, Drewry DH, Willson TM.
J Med Chem. (2020 Dec)63:14626-14646
DOI: 10.1021/acs.jmedchem.0c01174 |
PUBMED: 33215924 | IF(2018) = 6.1
PDB [P13]: 6ZJF
319: An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
Zarantonello A, Presumey J, Simoni L, Yalcin E, Fox R, Hansen A, Olesen HG, Thiel S, Johnson MB, Stevens B, Laursen NS, Carroll MC, Andersen GR.
J Immunol. (2020 Aug)UNK:pp. UNK
DOI: 10.4049/jimmunol.2000528 |
PUBMED: 32769120 | IF(2019) = 4.7
PDB [P13]: 6YSQ
318: Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine.
Malik D, Kobyłecki K, Krawczyk P, Poznański J, Jakielaszek A, Napiórkowska A, Dziembowski A, Tomecki R, Nowotny M.
Nucleic Acids Res. (2020 Aug)UNK:pp. UNK
DOI: 10.1093/nar/gkaa647 |
PUBMED: 32785623 | IF(2018) = 11.1
PDB [P13]: 6YWN 6YWO
317: Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1.
Shaikhqasem A, Dickmanns A, Neumann P, Ficner R.
J Med Chem. 2020 Jul 7545-7558
DOI: DOI: 10.1021/acs.jmedchem.0c00143 |
PUBMED: 32585100 | IF(2018) = 6.1
PDB [P14]: 6TVO
316: MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Sok P, Gógl G, Kumar GS, Alexa A, Singh N, Kirsch K, Sebő A, Drahos L, Gáspári Z, Peti W, Reményi A.
Structure (2020 Jul) pp. UNK
DOI: DOI: 10.1016/j.str.2020.06.007 |
PUBMED: 32649858
PDB [P14]: 6TCA
315: Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2.
Lindenblatt D, Nickelsen A, Applegate VM, Jose J, Niefind K.
J Med Chem. 2020 Jul7766-7772
DOI: DOI: 10.1021/acs.jmedchem.0c00587 |
PUBMED: 32589844 | IF(2018) = 6.1
PDB [P13]: 6TEW 6TEI
314: Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
Mpakali A, Saridakis E, Giastas P, Maben Z, Stern LJ, Larhed M, Hallberg M, Stratikos E.
ACS Med Chem Lett. 2020 Jul1429-1434
DOI: DOI: 10.1021/acsmedchemlett.0c00172 |
PUBMED: 32676150 | IF(2018) = 3.7
PDB [P13]: 6YDX
313: Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.
Kupski O, Funk LM, Sautner V, Seifert F, Worbs B, Ramsbeck D, Meyer F, Diederichsen U, Buchholz M, Schilling S, Demuth HU, Tittmann K.
Biochemistry. 2020 Jul2585-2591
DOI: DOI: 10.1021/acs.biochem.0c00337 |
PUBMED: 32551535 | IF(2018) = 3.0
PDB [P13P14]: 6YI1 6YJY
312: Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences.
Jolma A, Zhang J, Mondragón E, Morgunova E, Kivioja T, Laverty KU, Yin Y, Zhu F, Bourenkov G, Morris Q, Hughes TR, Maher LJ, Taipale J.
Genome Res. 2020 Julpp. UNK
DOI: DOI: 10.1101/gr.258848.119 |
PUBMED: 32703884 | IF(2019) = 9.9
PDB [P13]: 6SJD
311: Heptabladed β-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system.
Fujdiarová E, Houser J, Dobeš P, Paulíková G, Kondakov N, Kononov L, Hyršl P, Wimmerová M.
FEBS J. 2020 J npp. UNK
DOI: DOI: 10.1111/febs.15457 |
PUBMED: 32559333 | IF(2018) = 4.7
PDB [P13]: 6RGG
310: A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding.
Terekhov SS, Mokrushina YA, Nazarov AS, Zlobin A, Zalevsky A, Bourenkov G, Golovin A, Belogurov A, Osterman IA, Kulikova AA, Mitkevich VA, Lou HJ, Turk BE, Wilmanns M, Smirnov IV, Altman S, Gabibov AG.
Sci Adv. 2020 6(26):eaaz9861
DOI: 10.1126/sciadv.aaz9861 |
PUBMED: 32637600 | IF(2018) = 12.5
PDB [P13P14]: 6SUI 6SV5 6SUM 6SUL 6SUN
309: Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum.
Burda PC, Crosskey T, Lauk K, Zurborg A, Söhnchen C, Liffner B, Wilcke L, Pietsch E, Strauss J, Jeffries CM, Svergun DI, Wilson DW, Wilmanns M, Gilberger TW.
Cell Rep. 2020 Jun107817
DOI: 10.1016/j.celrep.2020.107817 |
PUBMED: 32579913 | IF(2018) = 8.1
PDB [P13]: 6TLB
308: Crystal structures of native cytochrome c6 from Thermosynechococcus elongatus in two different space groups and implications for its oligomerization.
Falke S, Feiler C, Chapman H, Sarrou I.
Acta Crystallogr F Struct Biol Commun (2020 Sep)76:444-452
DOI: 10.1107/s2053230x20010249 |
PUBMED: 32880593 | IF(2019) = 0.97
PDB [P13]: 6TR1
307: Crystal and solution structures of fragments of the human leucocyte commonantigen-related protein.
Vilstrup J, Simonsen A, Birkefeldt T, Strandbygard D, Lyngso J, Pedersen JS, Thirup S,
Acta Crystallogr D Struct Biol. 2020 May 1;76(Pt 5):406-417.
DOI: 10.1107/S2059798320003885 |
PUBMED: 32355037 | IF(2018) = 3.2
PDB [P14]: 6TPV
306: Molecular basis of MKLP2-dependent Aurora B transport from chromatin to theanaphase central spindle.
Serena M, Bastos RN, Elliott PR, Barr FA,
J Cell Biol. 2020 Jul 6;219(7).
DOI: 10.1083/JCB.201910059 |
PUBMED: 32356865 | IF(2018) = 8.8
PDB [P14]: 6YIE
305: High-resolution crystal structures of a "half sandwich"-type Ru(II) coordination compound bound to hen egg-white lysozyme and proteinase K.
Chiniadis L, Bratsos I, Bethanis K, Karpusas M, Giastas P, Papakyriakou A,
J Biol Inorg Chem. 2020 Apr 8.
DOI: 10.1007/S00775-020-01786-Z |
PUBMED: 32266561 | IF(2018) = 3.6
PDB [P13]: 6TXG
304: Crossing the Border: From Keto- to Imine Reduction in Short-ChainDehydrogenases/Reductases.
Muller M, Roth S, Stockinger P, Steff J, Steimle S, Sautner V, Tittmann K, Pleiss J,
ChemBioChem. 2020 Apr 21.
DOI: 10.1002/CBIC.202000233 |
PUBMED: 32315494 | IF(2018) = 2.6
PDB [P14]: 6Y4D
303: Structural and functional characterization of the severe fever withthrombocytopenia syndrome virus L protein.
Vogel D, Thorkelsson SR, Quemin ERJ, Meier K, Kouba T, Gogrefe N, Busch C, Reindl S, Gunther S, Cusack S, Grunewald K, Rosenthal M
Nucleic Acids Res. 2020 Jun 4;48(10):5749-5765.
DOI: 10.1093/nar/gkaa253 |
PUBMED: 32313945 | IF(2018) = 11.1
PDB [P14]: 6XYA
302: Flexible loops of New Delhi metallo-beta-lactamase modulate its activity towards different substrates.
Raczynska JE, Imiolczyk B, Komorowska M, Sliwiak J, Czyrko-Horczak J, Brzezinski K, Jaskolski M,
Int J Biol Macromol. 2020 Apr 28;158:104-115.
DOI: 10.1016/J.IJBIOMAC.2020.04.219 |
PUBMED: 32353499 | IF(2018) = 4.8
PDB [P13]: 6TWT
301: Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding:Hint on Differences in Selectivity Determinants of Both Proteins?
Ngo K, Collins-Kautz C, Gerstenecker S, Wagner B, Heine A, Klebe G,
J Med Chem. 2020 Mar 26;63(6):3274-3289.
DOI: 10.1021/ACS.JMEDCHEM.9B02061 |
PUBMED: 32011145 | IF(2018) = 6.1
PDB [P13]: 6T0M 6T0P
300: Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Singh K, Graf B, Linden A, Sautner V, Urlaub H, Tittmann K, Stark H, Chari A
Cell. 2020 Mar 19;180(6):1130-1143.e20.
DOI: 10.1016/j.cell.2020.02.034 |
PUBMED: 32160528 | IF(2018) = 36.2
PDB [P14]: 6QL9 6QL7
299: A Proof-of-Concept Fragment Screening of a Hit-Validated 96-Compounds Libraryagainst Human Carbonic Anhydrase II.
Glockner S, Heine A, Klebe G
Biomolecules. 2020 Mar 29;10(4).
DOI: 10.3390/BIOM10040518 |
PUBMED: 32235320 | IF(2019) = 4.7
PDB [P13P14]: 6S9Z 6RMP 5M78
298: Halogenated and di-substituted benzenesulfonamides as selective inhibitors ofcarbonic anhydrase isoforms.
Zaksauskas A, Capkauskaite E, Jezepcikas L, Linkuviene V, Paketuryte V, Smirnov A, Leitans J, Kazaks A, Dvinskis E, Manakova E, Grazulis S, Tars K, Matulis D,
Eur J Med Chem. 2020 Jan 1;185:111825.
DOI: 10.1016/J.EJMECH.2019.111825 |
PUBMED: 31740053 | IF(2018) = 4.8
PDB [P14]: 6R6Y
297: Regioselectivity of hyoscyamine 6β-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations.
Kluza A, Wojdyla Z, Mrugala B, Kurpiewska K, Porebski PJ, Niedzialkowska E, Minor W, Weiss MS, Borowski T.
Dalton T. ( 2020 Apr ) 49 :4454-4469
DOI: 10.1039/d0dt00302f |
PUBMED: 32182320 | IF(2018) = 4.1
PDB [P13]: 6TTM
296: Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture.
Gulen B, Rosselin M, Fauser J, Albers MF, Pett C, Krisp C, Pogenberg V, Schlüter H, Hedberg C, Itzen A.
Nat Chem. (2020 Aug)12:732-739
DOI: 10.1038/s41557-020-0484-6 |
PUBMED: 32632184 | IF(2019) = 21.7
PDB [P13]: 6SIU
295: Loss of GFAT-1 feedback regulation activates the hexosamine pathway thatmodulates protein homeostasis.
Ruegenberg S, Horn M, Pichlo C, Allmeroth K, Baumann U, Denzel MS,
Nat Commun. 2020 Feb 4;11(1):687.
DOI: 10.1038/s41467-020-14524-5 |
PUBMED: 32019926 | IF(2022) = 14.9
PDB [P13]: 6SVO
294: Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2.
Hamann F, Schmitt A, Favretto F, Hofele R, Neumann P, Xiang S, Urlaub H, Zweckstetter M, Ficner R,
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2948-2956.
DOI: 10.1073/pnas.1907960117 |
PUBMED: 31974312 | IF(2019) = 9.4
PDB [P13P14]: 6R4E 6RM8 6RMC 6RMB 6RMA 6RM9
293: p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Gebel J, Tuppi M, Chaikuad A, Hotte K, Schroder M, Schulz L, Lohr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dotsch V,
Nat Chem Biol. 2020 Jul 27. pii: 10.1038/s41589-020-0600-3. doi:10.1038/s41589-020-0600-3.
DOI: 10.1038/s41589-020-0600-3 [doi] |
PUBMED: 32719556 | IF(2020) = 41.8
PDB [P13]: 6RU6
292: Structure of a robust bacterial protein cage and its application as a versatile biocatalytic platform through enzyme encapsulation.
Lončar N, Rozeboom HJ, Franken LE, Stuart MCA, Fraaije MW.
Biochem Biophys Res Commun. (2020 Aug)529:548-553
DOI: 10.1016/j.bbrc.2020.06.059 |
PUBMED: 32736672 | IF(2019) = 3.0
PDB [P13]: 6I9G
291: A Novel Polyester Hydrolase From the Marine Bacterium Pseudomonas aestusnigri - Structural and Functional Insights.
Bollinger A, Thies S, Knieps-Grünhagen E, Gertzen C, Kobus S, Höppner A, Ferrer M, Gohlke H, Smits SHJ, Jaeger .
Front Microbiol. (2020 )11:114
DOI: 10.3389/fmicb.2020.00114 |
PUBMED: 32117139 | IF(2019) = 4.2
PDB [P13]: 6SCD
290: The structural basis of fungal glucuronoyl esterase activity on natural substrates.
Ernst HA, Mosbech C, Langkilde AE, Westh P, Meyer AS, Agger JW, Larsen S
Nat Commun. 2020 Feb 24;11(1):1026.
DOI: 10.1038/S41467-020-14833-9 |
PUBMED: 32094331 | IF(2022) = 14.9
PDB [P13]: 6RU1
289: Triple-Helix-Stabilizing Effects in Collagen Model Peptides ContainingPPII-Helix-Preorganized Diproline Modules.
Maassen A, Gebauer JM, Theres Abraham E, Grimm I, Neudorfl JM, Kuhne R, Neundorf I, Baumann U, Schmalz HG,
ngew Chem Int Ed Engl. 2020 Jan 16.
DOI: 10.1002/ANIE.201914101 |
PUBMED: 31944532
PDB [P13]: 6SYJ
288: Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
Lillebostad PAG, Raasakka A, Hjellbrekke SJ, Patil S, Røstbø T, Hollås H, Sakya SA, Szigetvari PD, Vedeler A, Kursula P.
Biomolecules (2020 Apr)10:pp. UNK
DOI: 10.3390/biom10040660 |
PUBMED: 32344647
PDB [P13]: 6TU2
287: The Impact of pH on Catalytically Critical Protein Conformational Changes: The Case of the Urease, a Nickel Enzyme.
Mazzei L, Cianci M, Benini S, Ciurli S
Chemistry. 2019 Sep 18;25(52):12145-12158.
DOI: 10.1002/CHEM.201902320 |
PUBMED: 31271481 | IF(2019) = 4.9
PDB [P13]: 6RP1 6RKG
286: Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties.
Gagner VA, Lundholm I, Garcia-Bonete MJ, Rodilla H, Friedman R, Zhaunerchyk V, Bourenkov G, Schneider T, Stake J, Katona G,
Sci Rep. 2019 Dec 17;9(1):19281.
DOI: 10.1038/s41598-019-55777-5 |
PUBMED: 31848402 | IF(2022) = 5.0
PDB [P14]: 6SW0 6SVG 6SVZ 6SVU 6SVW 6RIV 6SVX 6SVD 6SUX 6SVV 6SV9 6SV8 6SVB 6SV0 6SV6 6SVJ 6SVI 6SVN 6SVR
285: Identification and characterization of a novel chemotype for human TLR8 inhibitors.
Sribar D, Grabowski M, Murgueitio MS, Bermudez M, Weindl G, Wolber G,
Eur J Med Chem. 2019 Oct 1;179:744-752. Epub2019 Jun 29.
DOI: 10.1016/J.EJMECH.2019.06.084 |
PUBMED: 31284084 | IF(2018) = 4.8
PDB [P14]: 6R6F
284: Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.
De Bortoli F, Neumann A, Kotte A, Timmermann B, Schuler T, Wahl MC, Loll B, Heyd F,
Nucleic Acids Res. 2019 Jun 20;47(11):5867-5879.
DOI: 10.1093/nar/gkz243 |
PUBMED: 30949712 | IF(2018) = 11.1
PDB [P14]:
283: Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses.
Alvarez CE, Bovdilova A, Hoppner A, Wolff CC, Saigo M, Trajtenberg F, Zhang T, Buschiazzo A, Nagel-Steger L, Drincovich MF, Lercher MJ, Maurino VG,
Nat Plants. 2019 Jul;5(7):755-765. Epub 2019 Jun 24.
DOI: 10.1038/s41477-019-0451-7 |
PUBMED: 31235877 | IF(2019) = 13.3
PDB [P13]:
282: Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target.
Schussler S, Haase I, Perbandt M, Illarionov B, Siemens A, Richter K, Bacher A, Fischer M, Grawert T,
Acta Crystallogr F Struct Biol Commun. 2019 Sep 1;75(Pt 9):586-592. Epub 2019 Aug 30.
DOI: 10.1107/S2053230X19010902 |
PUBMED: 31475925 | IF(2019) = 0.97
PDB [P14]: 4UQF
281: Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.
Giastas P, Mpakali A, Papakyriakou A, Lelis A, Kokkala P, Neu M, Rowland P, Liddle J, Georgiadis D, Stratikos
Proc Natl Acad Sci U S A. 2019 Dec
DOI: 10.1073/pnas.1912070116 |
PUBMED: 31843903 | IF(2019) = 9.4
PDB [P13]: 6RYF 6RQX
280: Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype.
Driller R, Ballaschk M, Schmieder P, Uchanska-Ziegler B, Ziegler A, Loll B,
J Biol Chem. 2019 Sep 6;294(36):13269-13279. Epub 2019 Jul 11.
DOI: 10.1074/jbc.RA119.008937 |
PUBMED: 31296658 | IF(2018) = 4.1
PDB [P14]: 5IB3
279: Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.
Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U
Cell. 2019 Dec 12;179(7):1537-1550.e19.
DOI: 10.1016/j.cell.2019.11.024 |
PUBMED: 31835032 | IF(2018) = 36.2
PDB [P13]: 6RFG
278: Visualization of protein crystals by high-energy phase-contrast X-ray imaging.
Polikarpov M, Bourenkov G, Snigireva I, Snigirev A, Zimmermann S, Csanko K, Brockhauser S, Schneider TR,
Acta Crystallogr D Struct Biol. 2019 Nov 1;75(Pt 11):947-958. Epub 2019 Oct 31.
DOI: 10.1107/S2059798319011379 |
PUBMED: 31692469 | IF(2018) = 3.2
PDB [P14]:
277: Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7.
de Mare SW, Venskutonyte R, Eltschkner S, de Groot BL, Lindkvist-Petersson K,
Structure. 2019 Nov 29.
DOI: 10.1016/j.str.2019.11.011 |
PUBMED: 31831212 | IF(2022) = 5.0
PDB [P13]: 6QZJ 6QZI
276: The Structure of the Elusive Urease-Urea Complex Unveils the Mechanism of a Paradigmatic Nickel-Dependent Enzyme.
Mazzei L, Cianci M, Benini S, Ciurli S,
Angew Chem Int Ed Engl. 2019 May 27;58(22):7415-7419. Epub 2019 Apr 30.
DOI: 10.1002/ANIE.201903565 |
PUBMED: 30969470 | IF(2019) = 13.0
PDB [P13]: 6QDY
275: Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold.
Sykorova P, Novotna J, Demo G, Pompidor G, Dubska E, Komarek J, Fujdiarova E, Houser J, Haronikova L, Varrot A, Shilova N, Imberty A, Bovin N, Pokorna M, Wimmerova M,
Int J Biol Macromol. 2019 Nov 18.
DOI: 10.1016/J.IJBIOMAC.2019.10.200 |
PUBMED: 31751748 | IF(2018) = 4.8
PDB [P13]: 6GXR 6GXS
274: Molecular insight into a new low-affinity xylan binding module from thexylanolytic gut symbiont Roseburia intestinalis.
Leth ML, Ejby M, Madland E, Kitaoku Y, Slotboom DJ, Guskov A, Aachmann FL, Abou Hachem M,
FEBS J. 2019 Nov 6.
DOI: 10.1111/FEBS.15117 |
PUBMED: 31693302 | IF(2018) = 4.7
PDB [P13]: 6SGF
273: Unique structure and function of viral rhodopsins.
Bratanov D, Kovalev K, Machtens JP, Astashkin R, Chizhov I, Soloviov D, Volkov D, Polovinkin V, Zabelskii D, Mager T, Gushchin I, Rokitskaya T, Antonenko Y, Alekseev A, Shevchenko V, Yutin N, Rosselli R, Baeken C, Borshchevskiy V, Bourenkov G, Popov A, Balandin T, Buldt G, Manstein DJ, Rodriguez-Valera F, Fahlke C, Bamberg E, Koonin E, Gordeliy V,
Nat Commun. 2019 Oct 30;10(1):4939.
DOI: 10.1038/S41467-019-12718-0 |
PUBMED: 31666521 | IF(2022) = 14.9
PDB [P14]: 6SQG 6XYT
272: Optical performance and radiation stability of polymer X-ray refractive nano-lenses.
Barannikov A, Polikarpov M, Ershov P, Bessonov V, Abrashitova K, Snigireva I, Yunkin V, Bourenkov G, Schneider T, Fedyanin AA, Snigirev A,
J Synchrotron Rad. 2019 May 1;26(Pt 3):714-719. Epub 2019 Apr 1.
DOI: 10.1107/S1600577519001656 |
PUBMED: | IF(2018) = 2.5
PDB [P14]:
271: Molecular features of the UNC-45 chaperone critical for binding and foldingmuscle myosin.
Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T
Nat Commun. 2019 Oct 21;10(1):4781.
DOI: 10.1038/S41467-019-12667-8 |
PUBMED: 31636255 | IF(2022) = 14.9
PDB [P13]: 6QDJ
270: CRL-based ultra-compact transfocator for X-ray focusing and microscopy.
Narikovich A, Polikarpov M, Barannikov A, Klimova N, Lushnikov A, Lyatun I, Bourenkov G, Zverev D, Panormov I, Sinitsyn A, Snigireva I, Snigirev A,
J Synchrotron Rad. 2019 Jul 1;26(Pt 4):1208-1212. Epub 2019 Jun 18.
DOI: 10.1107/S1600577519005708 |
PUBMED: | IF(2018) = 2.5
PDB [P14]:
269: Crystal structure of the EcoKMcrA N-terminal domain (NEco): recognition of modified cytosine bases without flipping.
Slyvka A, Zagorskaite E, Czapinska H, Sasnauskas G, Bochtler M,
Nucleic Acids Res. 2019 Nov 14.
DOI: 10.1093/nar/gkz1017 |
PUBMED: 31724709 | IF(2018) = 11.1
PDB [P14]: 6T22 6T21
268: Metal binding to the dynamic cytoplasmic domain of the cation diffusionfacilitator (CDF) protein MamM induces a 'locked-in' configuration.
Barber-Zucker S, Hall J, Mangapuram SV, Kass I, Kolusheva S, MacMillan F, Zarivach R, Henn A,
FEBS J. 2019 Jun;286(11):2193-2215. Epub 2019 Mar 20.
DOI: 10.1111/febs.14795 |
PUBMED: 30811856 | IF(2018) = 4.7
PDB [P13]: 6G55
267: UNEXPECTED ENZYME-CATALYSED [4+2] CYCLOADDITION AND REARRANGEMENT IN POLYETHER ANTIBIOTIC BIOSYNTHESIS
R.LITTLE,F.C.R.PAIVA,R.JENKINS,H.HONG,Y.SUN,Y.DEMYDCHUK, M.SAMBORSKYY,M.TOSIN,F.J.LEEPER,M.V.B.DIAS,P.F.LEADLAY
Nat Catal. 2019 2:1045-1054
DOI: 10.1038/S41929-019-0351-2 |
PUBMED: NONE | IF(2021) = 47.2
PDB [P13]: 6NNW
266: The Crystal Structure of the Plasmodium falciparum PdxK Provides an Experimental Model for Pro-Drug Activation
Gao K, Wang W, Kronenberger T, Wrenger C, Groves MR
Crystals. 2019 9(10): 534
DOI: 10.3390/CRYST9100534 |
PUBMED: | IF(2018) = 2.4
PDB [P13]: 6SU9
265: Liquid application method for time-resolved analyses by serial synchrotron crystallography.
Mehrabi P, Schulz EC, Agthe M, Horrell S, Bourenkov G, von Stetten D, Leimkohl JP, Schikora H, Schneider TR, Pearson AR, Tellkamp F, Miller RJD
Nat Methods. 2019 Oct;16(10):979-982. Epub 2019Sep 16.
DOI: 10.1038/S41592-019-0553-1 |
PUBMED: 31527838 | IF(2018) = 28.5
PDB [P14]: 6RNC 6RNB 6RND 6RNF 6QNJ 6QNH 6QNI 6QND 6QNB 6QNC
264: Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
Voss M, Toelzer C, Bhandari DD, Parker JE, Niefind K
J Struct Biol. 2019 Sep 21.
DOI: 10.1016/J.JSB.2019.09.007 |
PUBMED: 31550533 | IF(2018) = 3.8
PDB [P13]: 6I8H
263: Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal are negatively coupled.
Moritzer AC, Niemann HH
Protein Sci. 2019 Oct 7.
DOI: 10.1002/PRO.3739 |
PUBMED: 31589794 | IF(2018) = 2.4
PDB [P13]: 6SLT 6SLS
262: Sub-Atomic Resolution Crystal Structures Reveal Conserved Geometric Outliers atFunctional Sites.
Laulumaa S, Kursula P,
Molecules. 2019 Aug 22;24(17).
DOI: 10.3390/molecules24173044. |
PUBMED: 31443388 | IF(2020) = 3.3
PDB [P13]: 6S2S
261: Marine Proteobacteria metabolize glycolate via the beta-hydroxyaspartate cycle.
Schada von Borzyskowski L, Severi F, Kruger K, Hermann L, Gilardet A, Sippel F, Pommerenke B, Claus P, Cortina NS, Glatter T, Zauner S, Zarzycki J, Fuchs BM, Bremer E, Maier UG, Amann RI, Erb TJ,
Nature. 2019 Nov;575(7783):500-504. Epub 2019 Nov13.
DOI: 10.1038/s41586-019-1748-4 |
PUBMED: 31723261 | IF(2018) = 43.1
PDB [P13]: 6RQA
260: High-throughput peptide-MHC complex generation and kinetic screenings of TCRswith peptide-receptive HLA-A*02:01 molecules.
Moritz A, Anjanappa R, Wagner C, Bunk S, Hofmann M, Pszolla G, Saikia A, Garcia-Alai M, Meijers R, Rammensee HG, Springer S, Maurer D,
Sci Immunol. 2019 Jul 19;4(37).
DOI: 10.1126/sciimmunol.aav0860 |
PUBMED: 31324691 | IF(2018) = 10.5
PDB [P13P14]: 6Q3K 6Q3S
259: Structural insights into synthetic ligands targeting A-A pairs in disease-relatedCAG RNA repeats.
Mukherjee S, Blaszczyk L, Rypniewski W, Falschlunger C, Micura R, Murata A, Dohno C, Nakatani K, Kiliszek A,
Nucleic Acids Res. 2019 Nov 18;47(20):10906-10913.
DOI: 10.1093/nar/gkz832 |
PUBMED: 31566242 | IF(2018) = 11.1
PDB [P13]: 6QIQ
258: Active Site Architecture and Reaction Mechanism Determination of Cold Adapted beta-d-galactosidase from Arthrobacter sp. 32cB.
Rutkiewicz M, Bujacz A, Wanarska M, Wierzbicka-Wos A, Cieslinski H
Int J Mol Sci. 2019 Sep 3;20(17).
DOI: 10.3390/ijms20174301 |
PUBMED: 31484304 | IF(2018) = 4.2
PDB [P13]: 6SE8
257: Low-barrier hydrogen bonds in enzyme cooperativity.
Dai S, Funk LM, von Pappenheim FR, Sautner V, Paulikat M, Schroder B, Uranga J, Mata RA, Tittmann K,
Nature. 2019 Sep 18.
DOI: 10.1038/s41586-019-1581-9 |
PUBMED: 31534226 | IF(2018) = 43.1
PDB [P13P14]: 6HAD 6HA3 6RJB 6RJC 6HAF
256: Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Pedersen DV, Gadeberg TAF, Thomas C, Wang Y, Joram N, Jensen RK, Mazarakis SMM, Revel M, El Sissy C, Petersen SV, Lindorff-Larsen K, Thiel S, Laursen NS, Fremeaux-Bacchi V, Andersen GR,
Front Immunol. 2019 Aug 22;10:2007. eCollection2019.
DOI: 10.3389/fimmu.2019.02007 |
PUBMED: 31507604 | IF(2018) = 6.4
PDB [P13P14]: 6SEJ 6RV6 6RUV 6RUR 6RU5 6RU3
255: Time-resolved crystallography reveals allosteric communication aligned withmolecular breathing.
Mehrabi P, Schulz EC, Dsouza R, Muller-Werkmeister HM, Tellkamp F, Miller RJD, Pai EF,
Science. 2019 Sep 13;365(6458):1167-1170.
DOI: 10.1126/SCIENCE.AAW9904 |
PUBMED: 31515393 | IF(2018) = 41.1
PDB [P14]: 6QI1 6QHY 6QHX
254: The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNABinding Domain.
Manav MC, Turnbull KJ, Jurenas D, Garcia-Pino A, Gerdes K, Brodersen DE,
Structure. 2019 Sep 4.
DOI: 10.1016/J.STR.2019.08.008 |
PUBMED: 31495532 | IF(2022) = 5.0
PDB [P13P14]: 6HPB 6HPC
253: Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure andAffinities of Inhibitors.
Kazokaite J, Kairys V, Smirnoviene J, Smirnov A, Manakova E, Tolvanen M, Parkkila S, Matulis D,
Sci Rep. 2019 Sep 3;9(1):12710.
DOI: 10.1038/S41598-019-49094-0 |
PUBMED: 31481705 | IF(2022) = 5.0
PDB [P14]: 6QL3 6QL2 6QL1
252: Ternary structure of the outer membrane transporter FoxA with resolved signallingdomain provides insights into TonB-mediated siderophore uptake.
Josts I, Veith K, Tidow H
Elife. 2019 Aug 6;8.
DOI: 10.7554/ELIFE.48528 |
PUBMED: 31385808 | IF(2018) = 7.6
PDB [P13]: 6I98 6I97
251: Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S byAutoubiquitination.
Liess AKL, Kucerova A, Schweimer K, Yu L, Roumeliotis TI, Diebold M, Dybkov O, Sotriffer C, Urlaub H, Choudhary JS, Mansfeld J, Lorenz S
Structure. 2019 Jun 4.
DOI: 10.1016/J.STR.2019.05.008 |
PUBMED: 31230944 | IF(2022) = 5.0
PDB [P14]: 6QH3
250: Class Id ribonucleotide reductase utilizes a Mn2(IV,III) cofactor and undergoes large conformational changes on metal loading.
Rozman Grinberg I, Berglund S, Hasan M, Lundin D, Ho FM, Magnuson A, Logan DT, Sjoberg BM, Berggren G
J Biol Inorg Chem. 2019 Aug 14.
DOI: 10.1007/S00775-019-01697-8 |
PUBMED: 31414238 | IF(2018) = 3.6
PDB [P13P14]: 6SF5 6SF4
249: Atomic view into Plasmodium actin polymerization, ATP hydrolysis, andfragmentation.
Kumpula EP, Lopez AJ, Tajedin L, Han H, Kursula I
PLoS Biol. 2019 Jun 14;17(6):e3000315.
DOI: 10.1371/JOURNAL.PBIO.3000315 |
PUBMED: 31199804 | IF(2018) = 8.4
PDB [P13]: 6I4M 6I4D 6I4E
248: Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1.
Pichlo C, Juetten L, Wojtalla F, Schacherl M, Diaz D, Baumann U,
J Biol Chem. 2019 Jun 10.
DOI: 10.1074/jbc.RA119.009029 |
PUBMED: 31182482 | IF(2018) = 4.1
PDB [P13]: 6R59 6R4X
247: NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly highligand release efficacy.
Gardill BR, Schmidt K, Muller YA,
J Struct Biol. 2019 May 16.
DOI: 10.1016/J.JSB.2019.05.006 |
PUBMED: 31103428 | IF(2018) = 3.8
PDB [P13]: 6HGG 6HGJ 6HGI 6HGK
246: Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
Andres F, Iamele L, Meyer T, Stuber JC, Kast F, Gherardi E, Niemann HH, Pluckthun A,
J Mol Biol. 2019 May 3;431(10):2020-2039. Epub2019 Mar 28.
DOI: 10.1016/J.JMB.2019.03.024 |
PUBMED: 30930049 | IF(2018) = 5.1
PDB [P13]: 6GCU
245: Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to asubstrate.
Palm GJ, Reisky L, Bottcher D, Muller H, Michels EAP, Walczak MC, Berndt L, Weiss MS, Bornscheuer UT, Weber G,
Nat Commun. 2019 Apr 12;10(1):1717.
DOI: 10.1038/S41467-019-09326-3 |
PUBMED: 30979881 | IF(2022) = 14.9
PDB [P13]: 6QGC
244: Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in theBiosynthesis of Gentamicin.
de Araujo NC, Bury PDS, Tavares MT, Huang F, Parise-Filho R, Leadlay P, Dias MVB,
ACS Chem Biol. 2019 May 17;14(5):925-933. Epub2019 Apr 30.
DOI: 10.1021/ACSCHEMBIO.9B00115 |
PUBMED: 30995396 | IF(2019) = 4.43
PDB [P13]: 6NOR
243: A surface-exposed GH26 beta-mannanase from Bacteroides ovatus: Structure, role, and phylogenetic analysis of BoMan26B.
Bagenholm V, Wiemann M, Reddy SK, Bhattacharya A, Rosengren A, Logan DT, Stalbrand H,
J Biol Chem. 2019 Jun 7;294(23):9100-9117. Epub2019 Apr 18.
DOI: 10.1074/jbc.RA118.007171 |
PUBMED: 31000630 | IF(2018) = 4.1
PDB [P13]: 6HF2
242: Structural Insights into Curli CsgA Cross-beta Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents.
Perov S, Lidor O, Salinas N, Golan N, Tayeb-Fligelman E, Deshmukh M, Willbold D, Landau M
PLoS Pathog. 2019 Aug 30;15(8):e1007978. eCollection 2019 Aug.
DOI: 10.1371/journal.ppat.1007978 |
PUBMED: 31469892 | IF(2018) = 6.1
PDB [P14]: 6G8C 6G8D 6G9G
241: CH-PI INTERACTIONS PROMOTE THE CONVERSION OF HYDROXYPYRUVATE IN A CLASS II PYRUVATE ALDOLASE
S.R.MARSDEN,L.MESTROM,I.BENTO,P.L.HAGEDOORN,D.G.G.MCMILLAN, U.HANEFELD
Adv Synth Catal. 2019 , 361
DOI: 10.1002/ADSC.201900205 |
PUBMED: | IF(2018) = 5.5
PDB [P13]: 6R62
240: (p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch.
Zhang YE, Baerentsen RL, Fuhrer T, Sauer U, Gerdes K, Brodersen DE,
Mol Cell. 2019 Apr 16.
DOI: 10.1016/J.MOLCEL.2019.03.035 |
PUBMED: 31023582 | IF(2018) = 14.5
PDB [P13]: 6GFM
239: Crystal structures of the c-di-AMP synthesizing enzyme CdaA.
Heidemann JL, Neumann P, Dickmanns A, Ficner R,
J Biol Chem. 2019 May 22.
DOI: 10.1074/JBC.RA119.009246 |
PUBMED: 31118276 | IF(2018) = 4.1
PDB [P13P14]: 6HVM 6HVN 6HVL
238: Structure of a functional cap-binding domain in Rift Valley fever virus Lprotein.
Gogrefe N, Reindl S, Gunther S, Rosenthal M,
PLoS Pathog. 2019 May 28;15(5):e1007829.
DOI: 10.1371/JOURNAL.PPAT.1007829 |
PUBMED: 31136637 | IF(2018) = 6.1
PDB [P13]: 6QHG
237: Protein crystallization promotes type 2 immunity and is reversible by antibodytreatment.
Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Goncalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN,
Science. 2019 May 24;364(6442).
DOI: 10.1126/SCIENCE.AAW4295 |
PUBMED: 31123109 | IF(2018) = 41.1
PDB [P14]: 6QRN 6GKS 6GKQ
236: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebscycle.
Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K,
Nature. 2019 Apr 3.
DOI: 10.1038/S41586-019-1095-5 |
PUBMED: 30944476 | IF(2018) = 43.1
PDB [P13P14]: 6HXK 6QCL 6QFB
235: Structural Comparison of Enterococcus faecalis and Human Thymidylate SynthaseComplexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints aboutEnzyme Conformational Variabilities.
Pozzi C, Ferrari S, Luciani R, Tassone G, Costi MP, Mangani S,
Molecules. 2019 Mar 31;24(7).
DOI: 10.3390/MOLECULES24071257 |
PUBMED: 30935102 | IF(2020) = 3.3
PDB [P14]: 6QXH
234: Structural basis for RNA translocation by DEAH-box ATPases.
Hamann F, Enders M, Ficner R,
Nucleic Acids Res. 2019 Mar 4.
DOI: 10.1093/NAR/GKZ150 |
PUBMED: 30828714 | IF(2018) = 11.1
PDB [P13]: 6I3O 6QIE 6QIC 6I3P
233: Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by aReliable Path to Atomic Resolution CK2alpha' Structures.
Lindenblatt D, Nickelsen A, Applegate VM, Hochscherf J, Witulski B, Bouaziz Z, Marminon C, Bretner M, Le Borgne M, Jose J, Niefind K,
ACS Omega. 2019 Mar 19;4(3):5471-5478. eCollection2019 Mar 31.
DOI: 10.1021/acsomega.8b03415 |
PUBMED: 31559376 | IF(2018) = 2.6
PDB [P13]: 6HME
232: High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor.
Giastas P, Neu M, Rowland P, Stratikos E,
ACS Med Chem Lett. 2019 Feb 13;10(5):708-713. eCollection 2019 May 9.
DOI: 10.1021/ACSMEDCHEMLETT.9B00002 |
PUBMED: 31097987 | IF(2018) = 3.7
PDB [P13]: 6Q4R
231: An NAD(+) Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.
Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Svergun DI, Schnappinger D, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O,
Mol Cell. 2019 Mar 21;73(6):1282-1291.e8. Epub2019 Feb 18.
DOI: 10.1016/j.molcel.2019.01.028 |
PUBMED: 30792174 | IF(2018) = 14.5
PDB [P13]: 6FKG
230: Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 InhibitorsModified with Chiral Pyrrolidine Scaffolds.
Luxenburger A, Schmidt D, Ianes C, Pichlo C, Kruger M, von Drathen T, Brunstein E, Gainsford GJ, Baumann U, Knippschild U, Peifer C,
Molecules. 2019 Mar 1;24(5).
DOI: 10.3390/MOLECULES24050873 |
PUBMED: 30832206 | IF(2020) = 3.3
PDB [P13]: 6F1W
229: Active site complementation and hexameric arrangement in the GH family 29; astructure-function study of alpha-l-fucosidase isoenzyme 1 from Paenibacillusthiaminolyticus.
Kovalova T, Koval T, Benesova E, Vodickova P, Spiwok V, Lipovova P, Dohnalek J,
Glycobiology. 2019 Jan 1;29(1):59-73.
DOI: 10.1093/GLYCOB/CWY078 |
PUBMED: 30544181 | IF(2018) = 4.2
PDB [P13]: 6GN6
228: Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
Cruz-Migoni A, Canning P, Quevedo CE, Bataille CJR, Bery N, Miller A, Russell AJ, Phillips SEV, Carr SB, Rabbitts TH,
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2545-2550. Epub 2019 Jan 25.
DOI: 10.1073/PNAS.1811360116 |
PUBMED: 30683716 | IF(2019) = 9.4
PDB [P14]: 6GQW 6GQY 6GQX
227: Long-wavelength Mesh&Collect native SAD phasing from microcrystals.
Cianci M, Nanao M, Schneider TR,
Acta Crystallogr D Struct Biol. 2019 Feb 1;75(Pt 2):192-199. Epub 2019 Feb 11.
DOI: 10.1107/S2059798319002031 |
PUBMED: 30821707 | IF(2018) = 3.2
PDB [P13]: 6H2M
226: Structural and computational basis for potent inhibition of glutamatecarboxypeptidase II by carbamate-based inhibitors.
Barinka C, Novakova Z, Hin N, Bim D, Ferraris DV, Duvall B, Kabarriti G, Tsukamoto R, Budesinsky M, Motlova L, Rojas C, Slusher BS, Rokob TA, Rulisek L, Tsukamoto T.
Bioorg Med Chem. 2019 Jan 15;27(2):255-264. Epub 2018 Nov 14.
DOI: 10.1016/j.bmc.2018.11.022 |
PUBMED: 30552009 | IF(2018) = 2.5
PDB [P13]: 6EZ9 6FE5 6ETY 6F5L
225: Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.
Ural-Blimke Y, Flayhan A, Strauss J, Rantos V, Bartels K, Nielsen R, Pardon E, Steyaert J, Kosinski J, Quistgaard EM, Low C,
J Am Chem Soc. 2019 Jan 31.
DOI: 10.1021/JACS.8B11343 |
PUBMED: 30644743 | IF(2018) = 14.7
PDB [P13]: 6GS4 6GS7
224: Enzyme activity and structural features of three single-domain phloemcyclophilins from Brassica napus.
Hanhart P, Falke S, Garbe M, Rose V, Thiess M, Betzel C, Kehr J,
Sci Rep. 2019 Jun 27;9(1):9368.
DOI: 10.1038/s41598-019-45856-y |
PUBMED: 31249367 | IF(2022) = 5.0
PDB [P14]: 6HMZ
223: Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
Merő B, Radnai L, Gógl G, Tőke O, Leveles I, Koprivanacz K, Szeder B, Dülk M, Kudlik G, Vas V, Cserkaszky A, Sipeki S, Nyitray L, Vértessy BG, Buday L.
J Biol Chem. (2019 Mar)294:4608-4620
DOI: 10.1074/jbc.ra118.004732 |
PUBMED: 30659095 | IF(2018) = 4.1
PDB [P13]: 5NP2 5NP5 5NP3
222: Diamondoid Amino Acid-Based Peptide Kinase A Inhibitor Analogues.
Muller J, Kirschner RA, Berndt JP, Wulsdorf T, Metz A, Hrdina R, Schreiner PR, Geyer A, Klebe G,
ChemMedChem. 2019 Mar 22;14(6):663-672. Epub 2019Feb 19.
DOI: 10.1002/cmdc.201800779 |
PUBMED: 30677243 | IF(2018) = 3.0
PDB [P13]: 5OK3
221: Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics byl,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis.
Libreros-Zuniga GA, Dos Santos Silva C, Salgado Ferreira R, Dias MVB,
ACS Infect Dis. 2019 Feb 8;5(2):260-271. Epub2018 Dec 28.
DOI: 10.1021/ACSINFECDIS.8B00244 |
PUBMED: 30556998 | IF(2018) = 5.0
PDB [P13]: 6D4K
220: Design of two-tail compounds with rotationally fixed benzenesulfonamide ring asinhibitors of carbonic anhydrases.
Zaksauskas A, Capkauskaite E, Jezepcikas L, Linkuviene V, Kisonaite M, Smirnov A, Manakova E, Grazulis S, Matulis D,
Eur J Med Chem. 2018 Aug 5;156:61-78. Epub2018 Jun 27.
DOI: 10.1016/J.EJMECH.2018.06.059 |
PUBMED: 30006175 | IF(2018) = 4.8
PDB [P14]: 6G6T 6G7A 6G5L
219: Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.
Scheide-Noeth JP, Rosen M, Baumstark D, Dietz H, Mueller TD,
J Mol Biol. 2018 Dec 7.
DOI: 10.1016/J.JMB.2018.11.029 |
PUBMED: 30529748 | IF(2018) = 5.1
PDB [P13]: 6H41
218: Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMalpha peptides.
Salinas N, Colletier JP, Moshe A, Landau M
Nat Commun. 2018 Aug 29;9(1):3512.
DOI: 10.1038/s41467-018-05490-0 |
PUBMED: 30158633 | IF(2022) = 14.9
PDB [P14]: 6FHD
217: Structural and functional characterization of a family GH53 beta-1,4-galactanase from Bacteroides thetaiotaomicron that facilitates degradation of prebioticgalactooligosaccharides.
Boger M, Hekelaar J, van Leeuwen SS, Dijkhuizen L, Lammerts van Bueren A,
J Struct Biol. 2018 Dec 13.
DOI: 10.1016/J.JSB.2018.12.002 |
PUBMED: 30553858 | IF(2018) = 3.8
PDB [P13]: 6GPA
216: Structure-based switch of regioselectivity in the flavin-dependent tryptophan6-halogenase Thal.
Moritzer AC, Minges H, Prior T, Frese M, Sewald N, Niemann HH,
J Biol Chem. 2018 Dec 17.
DOI: 10.1074/JBC.RA118.005393 |
PUBMED: 30559288 | IF(2018) = 4.1
PDB [P13]: 6IB5 6H44 6H43
215: The cost of long catalytic loops in folding and stability of the ALS-associatedprotein SOD1.
Yang F, Wang H, Logan DT, Mu X, Danielsson J, Oliveberg M,
J Am Chem Soc. 2018 Oct 25.
DOI: 10.1021/JACS.8B08141 |
PUBMED: 30359015 | IF(2018) = 14.7
PDB [P14]: 6FLH
214: The hit-and-return system enables efficient time-resolved serial synchrotron crystallography.
Schulz EC, Mehrabi P, Muller-Werkmeister HM, Tellkamp F, Jha A, Stuart W, Persch E, De Gasparo R, Diederich F, Pai EF, Miller RJD,
Nat Methods. 2018 Nov;15(11):901-904. Epub 2018Oct 30.
DOI: 10.1038/S41592-018-0180-2 |
PUBMED: 30377366 | IF(2018) = 28.5
PDB [P14]: 6FSX 6GXH 6GXT
213: Crystal structure of human mARC1 reveals its exceptional position amongeukaryotic molybdenum enzymes.
Kubitza C, Bittner F, Ginsel C, Havemeyer A, Clement B, Scheidig AJ, ORCID: 0000-0002-2382-8818,
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):11958-11963. Epub 2018 Nov 5.
DOI: 10.1073/pnas.1808576115 |
PUBMED: 30397129 | IF(2019) = 9.4
PDB [P14]: 6FW2
212: Characterization of the catalytic flexible loop in the dihydroorotase domain ofthe human multi-enzymatic protein CAD.
Del Cano-Ochoa F, Grande-Garcia A, Reverte-Lopez M, D'Abramo M, Ramon-Maiques S,
J Biol Chem. 2018 Oct 12.
DOI: 10.1074/JBC.RA118.005494 |
PUBMED: 30315107 | IF(2018) = 4.1
PDB [P13]: 6HFS 6HFR 6HFQ 6HFP 6HFU 6HFK 6HFJ 6HFH 6HFN 6HFL
211: Towards a comprehensive understanding of the structural dynamics of a bacterialditerpene synthase during catalysis.
Driller R, Janke S, Fuchs M, Warner E, Mhashal AR, Major DT, Christmann M, Bruck T, Loll B
Nat Commun. 2018 Sep 28;9(1):3971.
DOI: 10.1038/S41467-018-06325-8 |
PUBMED: 30266969 | IF(2022) = 14.9
PDB [P14]: 6GGL
210: Recognition of modified cytosine variants by the DNA-binding domain ofmethyl-directed endonuclease McrBC.
Zagorskaite E, Manakova E, Sasnauskas G,
FEBS Lett. 2018 Sep 8.
DOI: 10.1002/1873-3468.13244 |
PUBMED: 30194838 | IF(2018) = 2.7
PDB [P13]: 6GCF
209: DNA recognition by Arabidopsis transcription factors ABI3 and NGA1
Sasnauskas G, Manakova E, Lapenas K, Kauneckaite K, Siksnys V
FEBS J. 2018 Nov;285(21):4041-4059.
DOI: 10.1111/febs.14649. Epub 2018 Sep 21. |
PUBMED: 30183137. | IF(2018) = 4.7
PDB [P14]: 5OS9
208: Tripeptide binding in a proton-dependent oligopeptide transporter.
Martinez Molledo M, Quistgaard EM, Low C,
FEBS Lett. 2018 Sep 8.
DOI: 10.1002/1873-3468.13246 |
PUBMED: 30194725 | IF(2018) = 2.7
PDB [P14]: 6GHJ
207: Crystal Structure of the Escherichia coli DExH-Box NTPase HrpB.
Pietrzyk-Brzezinska AJ, Absmeier E, Klauck E, Wen Y, Antelmann H, Wahl MC,
Structure. 2018 Aug 13.
DOI: 10.1016/J.STR.2018.07.013 |
PUBMED: 30174149 | IF(2022) = 5.0
PDB [P14]: 6EUD
206: Intriguing role of water in protein-ligand binding studied by neutroncrystallography on trypsin complexes.
Schiebel J, Gaspari R, Wulsdorf T, Ngo K, Sohn C, Schrader TE, Cavalli A, Ostermann A, Heine A, Klebe G
Nat Commun. 2018 Sep 3;9(1):3559.
DOI: 10.1038/s41467-018-05769-2 |
PUBMED: 30177695 | IF(2022) = 14.9
PDB [P14]: 5MNE 5MNN 5MNG 5MNQ 5MNF 5MNH 5MOP 5MOQ 5MOS
205: Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic SubunitQTRT1.
Johannsson S, Neumann P, Ficner R,
Biomolecules. 2018 Aug 24;8(3).
DOI: 10.3390/BIOM8030081 |
PUBMED: 30149595 | IF(2019) = 4.7
PDB [P14]: 6H45 6H42
204: Structural and Functional Characterization of the BcsG Subunit of the CelluloseSynthase in Salmonella typhimurium.
Sun L, Vella P, Schnell R, Polyakova A, Bourenkov G, Li F, Cimdins A, Schneider TR, Lindqvist Y, Galperin MY, Schneider G, Romling U,
J Mol Biol. 2018 Jul 12.
DOI: 10.1016/j.jmb.2018.07.008 |
PUBMED: 30017920 | IF(2018) = 5.1
PDB [P14]: 5OLT
203: Activity and structure of EcoKMcrA.
Czapinska H, Kowalska M, Zagorskaite E, Manakova E, Slyvka A, Xu SY, Siksnys V, Sasnauskas G, Bochtler M,
Nucleic Acids Res. 2018 Aug 10.
DOI: 10.1093/nar/gky731. |
PUBMED: 30107581 | IF(2018) = 11.1
PDB [P13]: 5OJH 6GHC
202: NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward theEPHrin Family.
Troster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Muller S, Kuster B, Medard G, Kudlinzki D, Schwalbe H,
ChemMedChem. 2018 Jun 21.
DOI: 10.1002/CMDC.201800398 |
PUBMED: 29928781 | IF(2018) = 3.0
PDB [P13]: 6FNF 6FNH 6FNG
201: Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Sokolov AV, Dadinova LA, Petoukhov MV, Bourenkov G, Dubova KM, Amarantov SV, Volkov VV, Kostevich VA, Gorbunov NP, Grudinina NA, Vasilyev VB, Samygina VR,
Biochemistry (Mosc). 2018 Jun;83(6):701-707.
DOI: 10.1134/S000629791806007X |
PUBMED: 30195326
PDB [P14]: 6FVE
200: Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiencyby the tRNA nucleoside queuosine.
Johannsson S, Neumann P, Wulf A, Welp LM, Gerber HD, Krull M, Diederichsen U, Urlaub H, Ficner R,
Sci Rep. 2018 Jun 11;8(1):8880.
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PUBMED: 29892076 | IF(2022) = 5.0
PDB [P13]: 6FDF
199: Structural and functional insights into the unique CBS-CP12 fusion protein familyin cyanobacteria.
Hackenberg C, Hakanpaa J, Cai F, Antonyuk S, Eigner C, Meissner S, Laitaoja M, Janis J, Kerfeld CA, Dittmann E, Lamzin VS,
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7141-7146. Epub 2018 Jun 18.
DOI: 10.1073/pnas.1806668115 |
PUBMED: 29915055 | IF(2019) = 9.4
PDB [P13]: 5NPL 5NVD 5NMU
198: Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Schmidt K, Gardill BR, Kern A, Kirchweger P, Borsch M, Muller YA,
Proc Natl Acad Sci U S A. 2018 May 14.
DOI: 10.1073/PNAS.1716666115 |
PUBMED: 29760101 | IF(2019) = 9.4
PDB [P14]: 5OM3 5OM5
197: Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.
Peterson K, Kumar R, Stenstrom O, Verma P, Verma PR, Hakansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ,
J Med Chem. 2018 Feb 8;61(3):1164-1175. Epub2018 Jan 11.
DOI: 10.1021/ACS.JMEDCHEM.7B01626 |
PUBMED: 29284090 | IF(2018) = 6.1
PDB [P13]: 5ODY
196: Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus.
Kubitza C, Faust A, Gutt M, ORCID: 0000-0001-5629-7665, Gath L, Ober D, Scheidig AJ,
Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):422-432. Epub 2018 Apr 24.
DOI: 10.1107/S2059798318003510. |
PUBMED: 29717713 | IF(2018) = 3.2
PDB [P14]: 5NMX 5NMW
195: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
Jensen RK, Pihl R, Gadeberg TAF, Jensen JK, Andersen KR, Thiel S, Laursen NS, Andersen GR,
J Biol Chem. 2018 Apr 27;293(17):6269-6281. Epub2018 Mar 1.
DOI: 10.1107/S1600576717014479 |
PUBMED: 29497000 | IF(2018) = 4.1
PDB [P14]: 6EHG
194: Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors.
Pernigo S, Chegkazi MS, Yip YY, Treacy C, Glorani G, Hansen K, Politis A, Bui S, Dodding MP, Steiner RA
Elife. 2018 Oct 15;7.
DOI: 10.7554/eLife.38362 |
PUBMED: 30320553 | IF(2018) = 7.6
PDB [P14]: 6FUZ
193: p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P
Nat Commun. 2018 Mar 9;9(1):1017.
DOI: 10.1107/S1600576717014479 |
PUBMED: 29523821 | IF(2022) = 14.9
PDB [P14]: 6EIH
192: The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific.
Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Sturzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C,
J Virol. 2018 May 9.
DOI: 10.1128/JVI.00226-18. |
PUBMED: 29743357 | IF(2018) = 4.3
PDB [P14]: 6GFC
191: Multispecific Substrate Recognition in a Proton-Dependent OligopeptideTransporter.
Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Low C,
Structure. 2018 Mar 6;26(3):467-476.e4. Epub 2018Feb 8.
DOI: 10.1016/j.str.2018.01.005 |
PUBMED: 29429879 | IF(2022) = 5.0
PDB [P14]: 5OXK 5OXP 5OXO 5OXN 6EIA 5OXQ
190: Structural basis of DNA target recognition by the B3 domain of Arabidopsisepigenome reader VAL1.
Sasnauskas G, Kauneckaite K, Siksnys V
Nucleic Acids Res. 2018 Apr 6.
DOI: 10.1093/NAR/GKY256 |
PUBMED: 29660015 | IF(2018) = 11.1
PDB [P14]: 6FAS
189: The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1helicase-like motor.
Toliusis P, Tamulaitiene G, Grigaitis R, Tuminauskaite D, Silanskas A, Manakova E, Venclovas C, Szczelkun MD, Siksnys V, Zaremba M,
Nucleic Acids Res. 2018 Mar 16;46(5):2560-2572.
DOI: 10.1093/NAR/GKY107 |
PUBMED: 29471489 | IF(2018) = 11.1
PDB [P14]: 6F1S
188: A family of unconventional deubiquitinases with modular chain specificitydeterminants.
Hermanns T, Pichlo C, Woiwode I, Klopffleisch K, Witting KF, Ovaa H, Baumann U, Hofmann K
Nat Commun. 2018 Feb 23;9(1):799.
DOI: 10.1038/S41467-018-03148-5 |
PUBMED: 29476094 | IF(2022) = 14.9
PDB [P13]: 6EI1
187: Structure Guided Lead Generation toward Nonchiral M. tuberculosis ThymidylateKinase Inhibitors.
Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Ainsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S
J Med Chem. 2018 Apr 12;61(7):2753-2775. Epub 2018 Mar 15.
DOI: 10.1021/ACS.JMEDCHEM.7B01570 |
PUBMED: 29510037 | IF(2018) = 6.1
PDB [P14]: 5NR7
186: Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1through DCC.
Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang JH, Meijers R
Neuron. 2018 Mar 21;97(6):1261-1267.e4. Epub2018 Mar 1.
DOI: 10.1016/J.NEURON.2018.02.010 |
PUBMED: 29503192 | IF(2018) = 14.4
PDB [P14]: 6FKQ
185: The structure of hydrogenase-2 from Escherichia coli: implications for H2-driven proton pumping.
Beaton SE, Evans RM, Finney AJ, Lamont CM, Armstrong FA, Sargent F, Carr SB
Biochem J. 2018 Apr 16;475(7):1353-1370.
DOI: 10.1042/BCJ20180053 |
PUBMED: 29555844
PDB [P14]: 6EHQ
184: Epsin and Sla2 form assemblies through phospholipid interfaces.
Garcia-Alai MM, Heidemann J, Skruzny M, Gieras A, Mertens HDT, Svergun DI, Kaksonen M, Uetrecht C, Meijers R
Nat Commun. 2018 Jan 23;9(1):328.
DOI: 10.1038/S41467-017-02443-X |
PUBMED: 29362354 | IF(2022) = 14.9
PDB [P14]: 6ENR 5ONF 5ON7
183: Transposase-DNA Complex Structures Reveal Mechanisms for ConjugativeTransposition of Antibiotic Resistance.
Rubio-Cosials A, Schulz EC, Lambertsen L, Smyshlyaev G, Rojas-Cordova C, Forslund K, Karaca E, Bebel A, Bork P, Barabas O
Cell. 2018 Mar 22;173(1):208-220.e20. Epub 2018 Mar 15.
DOI: 10.1016/J.CELL.2018.02.032 |
PUBMED: 29551265 | IF(2018) = 36.2
PDB [P13]: 6EN1 6EN2 6EN0 6EMY 6EMZ
182: Structural basis for PDZ domain interactions in the post-synaptic densityscaffolding protein Shank3.
Ponna SK, Ruskamo S, Myllykoski M, Keller C, Boeckers TM, Kursula P
J Neurochem. 2018 Feb 23.
DOI: 10.1111/JNC.14322 |
PUBMED: 29473168
PDB [P13]: 5OVV 5OVP
181: Structure and stability of the Human respiratory syncytial virus M2-1 RNA-bindingcore domain reveals a compact and cooperative folding unit.
Molina IG, Josts I, Almeida Hernandez Y, Esperante S, Salgueiro M, Garcia Alai MM, de Prat-Gay G, Tidow H,
Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):23-30. Epub 2017 Dec 15.
DOI: 10.1107/S2053230X17017381 |
PUBMED: 29372904 | IF(2019) = 0.97
PDB [P13]: 5NOH 5NKX
180: Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.
Petrova OA, Mantsyzov AB, Rodina EV, Efimov SV, Hackenberg C, Hakanpää J, Klochkov VV, Lebedev AA, Chugunova AA, Malyavko AN, Zatsepin TS, Mishin AV, Zvereva MI, Lamzin VS, Dontsova OA, Polshakov VI.
Nucleic Acids Res. (2018 Feb)46:1525-1540
DOI: 10.1093/nar/gkx1275 |
PUBMED: 29294091 | IF(2018) = 11.1
PDB [P13]: 5NPT
179: Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus smallalarmone synthetase RelP.
Manav MC, Beljantseva J, Bojer MS, Tenson T, Ingmer H, Hauryliuk V, Brodersen DE,
J Biol Chem. 2018 Jan 11.
DOI: 10.1074/JBC.RA117.001374 |
PUBMED: 29326162 | IF(2018) = 4.1
PDB [P13]: 6EWZ
178: Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23Receptor Enables Recruitment of the Shared Receptor IL-12Rbeta1.
Bloch Y, Bouchareychas L, Merceron R, Skladanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN
Immunity. 2018 Jan 16;48(1):45-58.e6. Epub2017 Dec 26.
DOI: 10.1016/J.IMMUNI.2017.12.008 |
PUBMED: 29287995 | IF(2018) = 21.5
PDB [P14]: 5NJD 5MXA 5MZV 5M85
177: Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Dolot R, Lam CH, Sierant M, Zhao Q, Liu FW, Nawrot B, Egli M, Yang X
Nucleic Acids Res. 2018 May 18;46(9):4819-4830.
DOI: 10.1093/nar/gky268. |
PUBMED: 29684204 | IF(2018) = 11.1
PDB [P13]: 6EO6
176: Structure of the mouse acidic amino acid decarboxylase GADL1.
Raasakka A, Mahootchi E, Winge I, Luan W, Kursula P, Haavik J,
Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):65-73. Epub 2018 Jan 1.
DOI: 10.1107/S2053230X17017848 |
PUBMED: 29372909 | IF(2019) = 0.97
PDB [P13]: 6ENZ
175: The dual role of MamB in magnetosome membrane assembly and magnetite biomineralization.
Plitzko JM, Schüler D, Zarivach R
Mol Microbiol. 2018 Feb;107(4):542-557.
DOI: 10.1111/mmi.13899. |
PUBMED: 29243866. | IF(2018) = 3.6
PDB [P13]: 5HOK
174: Crystal structure correlations with the intrinsic thermodynamics of humancarbonic anhydrase inhibitor binding.
Smirnov A, Zubriene A, Manakova E, Grazulis S, Matulis D,
PeerJ. 2018 Feb 26;6:e4412. eCollection 2018.
DOI: 10.7717/PEERJ.4412 |
PUBMED: 29503769
PDB [P14]: 5LLP 5MSB 5LLO 5LLG 5LLC 5OGO
173: Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent-Exposed Ribose-33 Pocket of tRNA-Guanine Transglycosylase.
Movsisyan LD, Schafer E, Nguyen A, Ehrmann FR, Schwab A, Rossolini T, Zimmerli D, Wagner B, Daff H, Heine A, Klebe G, Diederich F,
Chemistry. 2018 Jul 11;24(39):9957-9967.
DOI: 10.1002/chem.201801756 |
PUBMED: 29939431 | IF(2019) = 4.9
PDB [P14]: 5JSW 5JSV
172: Crystal structure of a novel domain of the motor subunit of the Type I restriction enzyme EcoR124 involved in complex assembly and DNA binding.
Grinkevich P, Sinha D, Iermak I, Guzanova A, Weiserova M, Ludwig J, Mesters JR, Ettrich RH.
J Biol Chem. 2018 Sep 28;293(39):15043-15054.
DOI: 10.1074/jbc.RA118.003978. Epub 2018 Jul 27. |
PUBMED: 30054276 | IF(2018) = 4.1
PDB [P13]: 5J3N
171: Molecular basis of the 14-3-3 protein-dependent activation of yeast neutraltrehalase Nth1.
Alblova M, Smidova A, Docekal V, Vesely J, Herman P, Obsilova V, Obsil T,
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9811-E9820. Epub 2017 Oct 30.
DOI: 10.1073/PNAS.1714491114 |
PUBMED: 29087344 | IF(2019) = 9.4
PDB [P13]: 5JTA
170: Urease Inhibition in the Presence of N-(n-Butyl)thiophosphoric Triamide, aSuicide Substrate: Structure and Kinetics.
Mazzei L, Cianci M, Contaldo U, Musiani F, Ciurli S
Biochemistry. 2017 Oct 10;56(40):5391-5404. Epub 2017 Sep 15.
DOI: 10.1021/ACS.BIOCHEM.7B00750 |
PUBMED: 28857549 | IF(2018) = 3.0
PDB [P13]: 5OL4
169: PROTEIN CRYSTALS IR LASER ABLATED FROM AQUEOUS SOLUTION AT HIGH SPEED RETAIN THEIR DIFFRACTIVE PROPERTIES: APPLICATIONS IN HIGH-SPEED SERIAL CRYSTALLOGRAPHY.
E.C.SCHULZ,J.KAUB,F.BUSSE,P.MEHRABI,H.M.MULLER-WERKMEISTER, E.F.PAI,W.D.ROBERTSON,R.J.D.MILLER
J Appl Crystallogr. 50:1773 2017
DOI: 10.1107/S1600576717014479 |
PUBMED:
PDB [P14]: 5NYV 5O2G
168: Crystal structure of a marine glycoside hydrolase family 99-related proteinlacking catalytic machinery.
Robb CS, Mystkowska AA, Hehemann JH
Protein Sci. 2017 Dec;26(12):2445-2450. Epub 2017 Nov 21.
DOI: 10.1002/PRO.3291 |
PUBMED: 28884852 | IF(2018) = 2.4
PDB [P13]: 5NGW
167: Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of ProteinKinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2alpha andIts Paralog CK2alpha'.
Hochscherf J, Lindenblatt D, Witulski B, Birus R, Aichele D, Marminon C, Bouaziz Z, Le Borgne M, Jose J, Niefind K
Pharmaceuticals (Basel). 2017 Dec 13;10(4).
DOI: 10.3390/PH10040098 |
PUBMED: 29236079
PDB [P13]: 5OOI
166: Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic.
Samygina VR, Sokolov AV, Bourenkov G, Schneider TR, Anashkin VA, Kozlov SO, Kolmakov NN, Vasilyev VB,
Metallomics. 2017 Dec 1;9(12):1828-1838. Epub 2017 Nov27.
DOI: 10.1039/C7MT00157F |
PUBMED: 29177316
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165: A New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site.
Mamais M, Degli Esposti A, Kouloumoundra V, Gustavsson T, Monti F, Venturini A, Chrysina ED, Markovitsi D, Gimisis T
Chemistry. 2017 Jul 3;23(37):8800-8805 Epub 2017Jun 19.
DOI: 10.1002/CHEM.201701591 |
PUBMED: 28493496 | IF(2019) = 4.9
PDB [P14]: 5MEM
164: Crystal structure and catalytic characterization of the dehydrogenase/reductaseSDR family member 4 (DHRS4) from Caenorhabditis elegans.
Kisiela M, Faust A, Ebert B, Maser E, Scheidig AJ,
FEBS J. 2017 Nov 19.
DOI: 10.1111/FEBS.14337 |
PUBMED: 29151266 | IF(2018) = 4.7
PDB [P14]: 5OJG 5OJI
163: Anthranilate phosphoribosyltransferase from the hyperthermophilic archaeon Thermococcus kodakarensis shows maximum activity with zinc and forms a uniquedimeric structure.
Perveen S, Rashid N, Tang XF, Imanaka T, Papageorgiou AC
FEBS Open Bio. 2017 Jul 24;7(8):1217-1230.
DOI: 10.1002/2211-5463.12264 |
PUBMED: 28781961
PDB [P13]: 5NOF
162: Crystal structures of serum albumins from domesticated ruminants and theircomplexes with 3,5-diiodosalicylic acid.
Bujacz A, Talaj JA, Zielinski K, Pietrzyk-Brzezinska AJ, Neumann P,
Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):896-909.
DOI: 10.1107/S205979831701470X |
PUBMED: 29095162 | IF(2018) = 3.2
PDB [P13]: 5ORF
161: Crystal structure of the Legionella pneumophila Lpg2936 in complex with thecofactor S-adenosyl-L-methionine reveals novel insights into the mechanism ofRsmE family methyltransferases.
Pinotsis N, Waksman G,
Protein Sci. 2017 Sep 22.
DOI: 10.1002/PRO.3305 |
PUBMED: 28940762 | IF(2018) = 2.4
PDB [P13]: 5O96
160: Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction.
Stranava M, Man P, Skálová T, Kolenko P, Blaha J, Fojtikova V, Martínek V, Dohnálek J, Lengalova A, Rosůlek M, Shimizu T, Martínková M
J Biol Chem. 2017 Dec 22;292(51):20921-20935.
DOI: 10.1074/jbc.M117.817023. Epub 2017 Nov 1. |
PUBMED: 29092908 | IF(2018) = 4.1
PDB [P13]: 5OHF
159: Dynamic control of RSK complexes by phosphoswitch-based regulation.
Gogl G, Biri-Kovacs B, Poti AL, Vadaszi H, Szeder B, Bodor A, Schlosser G, Acs A, Turiak L, Buday L, Alexa A, Nyitray L, Remenyi A,
FEBS J. 2017 Oct 30.
DOI: 10.1111/FEBS.14311 |
PUBMED: 29083550 | IF(2018) = 4.7
PDB [P14]: 5N7D
158: Structural Basis of the Selectivity of GenN, an AminoglycosideN-Methyltransferase Involved in Gentamicin Biosynthesis.
Bury PDS, Huang F, Li S, Sun Y, Leadlay PF, Dias MVB
ACS Chem Biol. 2017 Oct 9.
DOI: 10.1021/ACSCHEMBIO.7B00466 |
PUBMED: 28876898 | IF(2019) = 4.43
PDB [P13]: 5TYQ 5U4T 5U19
157: Mechanism of RNA polymerase II stalling by DNA alkylation
Malvezzi S, Farnung L, Aloisi CMN, Angelov T, Cramer P, Sturla SJ
Proc Natl Acad Sci U S A. 2017 Oct 30.
DOI: 10.1073/PNAS.1706592114 |
PUBMED: 29087308 | IF(2019) = 9.4
PDB [P13]: 5OT2
156: UbaLAI is a monomeric Type IIE restriction enzyme.
Sasnauskas G, Tamulaitiene G, Tamulaitis G, Calyseva J, Laime M, Rimseliene R, Lubys A, Siksnys V,
Nucleic Acids Res. 2017 Sep 19;45(16):9583-9594.
DOI: 10.1093/NAR/GKX634 |
PUBMED: 28934493 | IF(2018) = 11.1
PDB [P13]: 5O63
155: Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Hansen SB, Laursen NS, Andersen GR, Andersen KR,
Acta Crystallogr D Struct Biol. 2017 Oct 1;73(Pt 10):804-813. Epub 2017 Sep 27.
DOI: 10.1107/S2059798317013171 |
PUBMED: 28994409 | IF(2018) = 3.2
PDB [P13]: 5NM0 5NML
154: Lysozyme's lectin-like characteristics facilitates its immune defense function
Zhang R, Wu L, Eckert T, Burg-Roderfeld M, Rojas-Macias MA, Lüttek T, Krylov VB, Argunov DA, Datta A, Markart P, Guenther, A.; Norden, B.; Schauer, R.; Bhunia, A.; Enani, M. A.; Billeter, M.; Scheidig, A. J.; Nifantiev, N. E.; Siebert, H.-C.
Q Rev Biophys. 2017, 50.
DOI: 10.1017/S0033583517000075 |
PUBMED: 29233221 | IF(2018) = 6.6
PDB [P13]: 5LSH
153: Mechanistic insights into cyclic peptide generation by DnaE split-inteins throughquantitative and structural investigation.
Kick L, Harteis S, Koch MF, Schneider S,
ChemBioChem. 2017 Sep 15.
DOI: 10.1002/CBIC.201700503 |
PUBMED: 28914478 | IF(2018) = 2.6
PDB [P14]: 5OL5
152: The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery.
Prevost MS, Pinotsis N, Dumoux M, Hayward RD, Waksman G,
Sci Rep. 2017 Aug 25;7(1):9450.
DOI: 10.1038/S41598-017-10249-6 |
PUBMED: 28842705 | IF(2022) = 5.0
PDB [P13]: 5NNY
151: Structures of designed armadillo repeat proteins binding to peptides fused toglobular domains.
Hansen S, Kiefer JD, Madhurantakam C, Mittl PRE, Pluckthun A,
Protein Sci. 2017 Jul 10
DOI: 10.1002/PRO.3229 |
PUBMED: 28691351 | IF(2018) = 2.4
PDB [P14]: 5MFD
150: Mechanism of Transcription Anti-termination in Human Mitochondria.
Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D,
Cell. 2017 Oct 7.
DOI: 10.1016/J.CELL.2017.09.035 |
PUBMED: 29033127 | IF(2018) = 36.2
PDB [P13]: 5OL9
149: Structural Basis for Mitotic Centrosome Assembly in Flies.
Feng Z, Caballe A, Wainman A, Johnson S, Haensele AFM, Cottee MA, Conduit PT, Lea SM, Raff JW,
Cell. 2017 Jun 1;169(6):1078-1089.e13.
DOI: 10.1016/J.CELL.2017.05.030 |
PUBMED: 28575671 | IF(2018) = 36.2
PDB [P13]: 5MW9 5MW0
148: Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases
E.CAPKAUSKAITE,V.LINKUVIENE,A.SMIRNOV,G.MILINAVICIUTE,D.TIMM,A.KASILIAUSKAITE,E.MANAKOVA,S.GRAZULIS,D.MATULIS
Chemistry Select. 2017 2:5360-5371
DOI: 10.1002/SLCT.201700531 |
PUBMED:
PDB [P13]: 5LL4 5LL5 5LL9 5LLA
147: Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and KainateReceptors.
Mollerud S, Pinto A, Marconi L, Frydenvang K, Thorsen TS, Laulumaa S, Venskutonyte R, Winther S, Moral AMC, Tamborini L, Conti P, Pickering DS, Kastrup JS
ACS Chem Neurosci. 2017 Jul 21.
DOI: 10.1021/ACSCHEMNEURO.7B00201 |
PUBMED: 28691798 | IF(2019) = 4.5
PDB [P14]: 5NEB
146: Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhard V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M, Schwalbe H, Kuster B, Medard G,
ChemMedChem. 2017 May 24.
DOI: 10.1002/CMDC.201700217 |
PUBMED: 28544567 | IF(2018) = 3.0
PDB [P13]: 5NKA 5NKB 5NKC 5NKD 5NK6 5NK8 5NK9
145: Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by stericshielding and substrate fixation.
Newie J, Neumann P, Werner M, Mata RA, Ficner R, Feussner I
Sci Rep. 2017 May 18;7(1):2069.
DOI: 10.1038/S41598-017-02153-W |
PUBMED: 28522865 | IF(2022) = 5.0
PDB [P14]: 5MEG
144: Structure of a soluble epoxide hydrolase identified in Trichoderma reesei.
Wilson C, De Oliveira GS, Adriani PP, Chambergo FS, Dias MVB,
Biochim Biophys Acta. 2017 May 11.
DOI: 10.1016/J.BBAPAP.2017.05.004 |
PUBMED: 28502798
PDB [P13]: 5URO
143: Trapped intermediate state of plant pyruvate phosphate dikinase indicatessubsteps in catalytic swiveling domain mechanism.
Minges A, Hoppner A, Groth G,
Protein Sci. 2017 May 3.
DOI: 10.1002/PRO.3184 |
PUBMED: 28470715 | IF(2018) = 2.4
PDB [P13]: 5LU4
142: Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and2-Aminopyridine Become Protonated Upon Binding to Trypsin.
Schiebel J, Gaspari R, Sandner A, Ngo K, Gerber HD, Cavalli A, Ostermann A, Heine A, Klebe G
Angew Chem Int Ed Engl. 2017 Apr 18;56(17):4887-4890. Epub 2017 Mar 28.
DOI: 10.1002/ANIE.201701038 |
PUBMED: 28371253 | IF(2019) = 13.0
PDB [P14]: 5MN1 5MNC 5MNB 5MON
141: Core Mediator structure at 3.4 A extends model of transcription initiationcomplex.
Nozawa K, Schneider TR, Cramer P,
Nature. 2017 May 11;545(7653):248-251.
DOI: 10.1038/NATURE22328 |
PUBMED: 28467824 | IF(2018) = 43.1
PDB [P14]: 5N9J
140: EXPLAINING OPERATIONAL INSTABILITY OF AMINE TRANSAMINASES: SUBSTRATE-INDUCED INACTIVATION MECHANISM AND INFLUENCE OF QUATERNARY STRUCTURE ON ENZYME-COFACTOR INTERMEDIATE STABILITY.
T.BORNER,S.RAMISCH,E.REDDEM,S.BARTSCH,A.VOGEL, A.M.W.H.THUNNISSEN,P.ADLERCREUTZ,C.GREY
ACS Catalysis. 7:1259-1269 (2017)
DOI: 10.1021/ACSCATAL.6B02100 |
PUBMED: | IF(2018) = 12.1
PDB [P14]: 5LH9
139: Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Mickeviciute A, Timm DD, Gedgaudas M, Linkuviene V, Chen Z, Waheed A, Michailoviene V, Zubriene A, Smirnov A, Capkauskaite E, Baranauskiene L, Jachno J, Revuckiene J, Manakova E, Grazulis S, Matuliene J, Di Cera E, Sly WS, Matulis D, ORCID: http://orcid.org/0000-0002-6178-6276,
Eur Biophys J. 2017 Oct 3.
DOI: 10.1007/S00249-017-1256-0 |
PUBMED: 28975383
PDB [P14]: 5IPZ
138: Structure of the WipA protein reveals a novel tyrosine protein phosphataseeffector from Legionella pneumophila.
Pinotsis N, Waksman G
J Biol Chem. 2017 Jun 2;292(22):9240-9251. Epub2017 Apr 7.
DOI: 10.1074/JBC.M117.781948 |
PUBMED: 28389563 | IF(2018) = 4.1
PDB [P13]: 5N6X
137: Manszewski T, Szpotkowski K, Jaskolski M.
Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii.
IUCrJ. 2017 Apr 10;4(Pt 3):271-282. eCollection 2017 May 1.
DOI: 10.1107/S2052252517002433 |
PUBMED: 28512574 | IF(2020) = 4
PDB [P13]: 5M67 5M5K
136: Structural insights into reptarenavirus cap- snatching machinery
Rosenthal, M., Gogrefe, N., Vogel, D., Reguera, J., Rauschenberger, B., Cusack, S., Günther, S. & Reindl, S
PLoS Pathog. (2017) 13, e1006400-1006424.
DOI: 10.1371/journal.ppat.1006400 |
PUBMED: 28505175 | IF(2018) = 6.1
PDB [P13]: 5MUZ 5MV0
135: Crystal structure and biological implications of a glycoside hydrolase family 55 beta-1,3-glucanase from Chaetomium thermophilum.
Papageorgiou AC, Chen J, Li D,
Biochim Biophys Acta. 2017 May 4.
DOI: 10.1016/J.BBAPAP.2017.05.002 |
PUBMED: 28479293
PDB [P13]: 5M60
134: Structural and functional innovations in the real-time evolution of new(betaalpha)8 barrel enzymes.
Newton MS, Guo X, Soderholm A, Nasvall J, Lundstrom P, Andersson DI, Selmer M, Patrick WM
Proc Natl Acad Sci U S A. 2017 May 2;114(18):4727-4732. Epub 2017 Apr 17.
DOI: 10.1073/PNAS.1618552114 |
PUBMED: 28416687 | IF(2019) = 9.4
PDB [P14]: 5L6U
133: Functional and structural insight into properdin control of complement alternative pathway amplification.
Pedersen DV, Roumenina L, Jensen RK, Gadeberg TA, Marinozzi C, Picard C, Rybkine T, Thiel S, Sørensen UB, Stover C, Fremeaux-Bacchi V, Andersen GR.
EMBO J. 2017 Apr 13;36(8):1084-1099.
DOI: 10.15252/embj.201696173. Epub 2017 Mar 6. |
PUBMED: 28264884 | IF(2018) = 11.2
PDB [P14]: PDB:
132: Structural insights into the mechanism of the DEAH-box RNA helicase Prp43.
FTauchert MJ, Fourmann JB, Luhrmann R, Ficner R
Elife. 2017 Jan 16;6.
DOI: 10.7554/ELIFE.21510 |
PUBMED: 28092261 | IF(2016) = 8.3
PDB [P13]: 5LTA 5LTK 5LTJ
131: Structural aspects of nucleotide ligand binding by a bacterial 2Hphosphoesterase.
Myllykoski M, Kursula P,
PLoS One. 2017 Jan 31;12(1):e0170355.
DOI: 10.1371/JOURNAL.PONE.0170355 |
PUBMED: 28141848 | IF(2014) = 3.23
PDB [P13]: 5LDQ
130: Inactivation of urease by catechol: Kinetics and structure.
Mazzei L, Cianci M, Musiani F, Lente G, Palombo M, Ciurli S,
J Inorg Biochem. 2017 Jan;166:182-189. Epub2016 Nov 9.
DOI: 10.1016/J.JINORGBIO.2016.11.016 |
PUBMED: 27888701
PDB [P13]: 5G4H
129: Evaluating the Contribution of Transition-State Destabilization to Changes in theResidence Time of Triazole-Based InhA Inhibitors.
Spagnuolo LA, Eltschkner S, Yu W, Daryaee F, Davoodi S, Knudson SE, Allen EK, Merino J, Pschibul A, Moree B, Thivalapill N, Truglio JJ, Salafsky J, Slayden RA, Kisker C, Tonge PJ,
J Am Chem Soc. 2017 Feb 22.
DOI: 10.1021/JACS.6B11148 |
PUBMED: 28151657 | IF(2015) = 13.0
PDB [P13]: 5MTQ
128: Architecture and mechanism of the late endosomal Rab7-like Ypt7 guaninenucleotide exchange factor complex Mon1-Ccz1.
Kiontke S, Langemeyer L, Kuhlee A, Schuback S, Raunser S, Ungermann C, Kummel D,
Nat Commun. 2017 Jan 4;8:14034.
DOI: 10.1038/NCOMMS14034 |
PUBMED: 28051187 | IF(2015) = 11.3
PDB [P13]: 5LDD
127: Small Molecule Microarray Based Discovery of PARP14 Inhibitors.
Peng B, Thorsell AG, Karlberg T, Schuler H, Yao SQ,
Angew Chem Int Ed Engl. 2017 Jan 2;56(1):248-253. Epub 2016 Dec 5.
DOI: 10.1002/ANIE.201609655 |
PUBMED: 27918638 | IF(2015) = 11.7
PDB [P13]: 5LYH
126: Collapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, andconformational flexibility.
Myllykoski M, Baumann A, Hensley K, Kursula P
Amino Acids. 2017 Jan 2.
DOI: 10.1007/S00726-016-2376-Z |
PUBMED: 28044206 | IF(2016) = 3.2
PDB [P13]: 5LXX
125: Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to
Zubriene A, Smirnov A, Dudutiene V, Timm DD, Matuliene J, Michailoviene V, Zakšauskas A, Manakova E, Gražulis S, Matulis D
Carbonic Anhydrases. ChemMedChem. 2017 Jan 20;12(2):161-176.
DOI: 10.1002/cmdc.201600509. Epub 2016 Dec 21. |
PUBMED: 28001003.
PDB [P14]: 5E2M 5E2N 5DRS 5DOH
124: Glucose-1-phosphate uridylyltransferase from Erwinia amylovora: Activity, structure and substrate specificity.
Benini S, Toccafondi M, Rejzek M, Musiani F, Wagstaff BA, Wuerges J, Cianci M, Field RA.
Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt A):1348-1357.
DOI: 10.1016/j.bbapap.2017.08.015. Epub 2017 Aug 24. |
PUBMED: 28844747.
PDB [P13]: 4D48
123: Structural Analysis of beta-Fructofuranosidase from Xanthophyllomyces dendrorhousReveals Unique Features and the Crucial Role of N-Glycosylation inOligomerization and Activity.
Ramirez-Escudero M, Gimeno-Perez M, Gonzalez B, Linde D, Merdzo Z, Fernandez-Lobato M, Sanz-Aparicio J,
J Biol Chem. 2016 Mar 25;291(13):6843-57. Epub 2016Jan 28.
DOI: 10.1074/JBC.M115.708495 |
PUBMED: 26823463 | IF(2018) = 4.1
PDB [P13]: 5FKB 5FMB 5FKC
122: Ferrocene-Biotin Conjugates: Synthesis, Structure, Cytotoxic Activity and Interaction with Avidin
Blauz, A., Rychlik, B., Makal, A., Szulc, K., Strzelczyk, P., Bujacz, G., Zakrzewski, J., Wozniak, K., Plazuk, D.
Chempluschem 81: 1191-1201 (2016)
DOI: 10.1002/cplu.201600320 |
PUBMED:
PDB [P13]: 5HLM
121: Structural and Catalytic Properties of S1 Nuclease from Aspergillus oryzae Responsible for Substrate Recognition, Cleavage, Non-Specificity, and Inhibition.
Koval T, Ostergaard LH, Lehmbeck J, Norgaard A, Lipovova P, Duskova J, Skalova T, Trundova M, Kolenko P, Fejfarova K, Stransky J, Svecova L, Hasek J, Dohnalek J,
PLoS One. 2016 Dec 30;11(12):e0168832. eCollection 2016.
DOI: 10.1371/JOURNAL.PONE.0168832 |
PUBMED: 28036383 | IF(2018) = 2.8
PDB [P13]: 5FB9
120: First Structure-Activity Relationship of 17beta-Hydroxysteroid Dehydrogenase Type14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.
Braun F, Bertoletti N, Moller G, Adamski J, Steinmetzer T, Salah M, Abdelsamie AS, van Koppen CJ, Heine A, Klebe G, Marchais-Oberwinkler S,
J Med Chem. 2016 Dec 8;59(23):10719-10737. Epub 2016 Nov 18.
DOI: 10.1021/ACS.JMEDCHEM.6B01436 |
PUBMED: 27933965 | IF(2014) = 5.4
PDB [P13]: 5L7T 5L7Y
119: Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNAhelicase Brr2.
Absmeier E, Becke C, Wollenhaupt J, Santos KF, Wahl MC,
Cell Cycle. 2016 Nov 23:1-13.
DOI: 10.1080/15384101.2016.1255384 |
PUBMED: 27880071
PDB [P13]: 5M59
118: Structural basis of myelin-associated glycoprotein adhesion and signalling.
Pronker MF, Lemstra S, Snijder J, Heck AJ, Thies-Weesie DM, Pasterkamp RJ, Janssen BJ
Nat Commun. 2016 Dec 6;7:13584.
DOI: 10.1038/NCOMMS13584 |
PUBMED: 27922006 | IF(2022) = 14.9
PDB [P14]: 5LFU
117: Structural Characterization of the Avidin Interactions with Fluorescent Pyrene-Conjugates: 1-Biotinylpyrene and 1-Desthiobiotinylpyrene.
Strzelczyk P, Plazuk D, Zakrzewski J, Bujacz G
Molecules. 2016 Sep 27;21(10).
DOI: 10.3390/MOLECULES21101270 |
PUBMED: 27689976 | IF(2015) = 2.5
PDB [P13]: 5IRU 5IRW
116: Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance.
Barber-Zucker S, Uebe R, Davidov G, Navon Y, Sherf D, Chill JH, Kass I, Bitton R, Schuler D, Zarivach R
Sci Rep. 2016 Aug 23;6:31933.
DOI: 10.1038/SREP31933 |
PUBMED: 27550551 | IF(2015) = 5.2
PDB [P13]: 5HSP
115: Structural and functional characterization of a ruminal beta-glycosidase defines a novel subfamily of glycosyl hydrolase family 3 with permuted domain topology.
Ramirez-Escudero M, Del Pozo MV, Marin-Navarro J, Gonzalez B, Golyshin PN, Polaina J, Ferrer M, Sanz-Aparicio J
J Biol Chem. 2016 Sep 27.
DOI: 10.1074/JBC.M116.747527 |
PUBMED: 27679487 | IF(2014) = 4.57
PDB [P13]: 5K6M
114: A multicrystal diffraction data-collection approach for studying structural dynamics with millisecond temporal resolution.
Schubert R, Kapis S, Gicquel Y, Bourenkov G, Schneider TR, Heymann M, Betzel C, Perbandt M
IUCrJ. 2016 Oct 26;3(Pt 6):393-401. eCollection 2016 Nov 1.
DOI: 10.1107/S2052252516016304 |
PUBMED: 27840678 | IF(2016) = 5.31
PDB [P14]: 5EN4 5M62 5LH7 5EUV 5C9O 5C9L 5LMH 5LN0 5JXQ 5LH6 5LH5 5LH3 5LH1 5LH0 5F5V 5A62 5D4W 5F5T
113: Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs.
Heinzlmeir S, Kudlinzki D, Sreeramulu S, Klaeger S, Gande SL, Linhard V, Wilhelm M, Qiao H, Helm D, Ruprecht B, Saxena K, Medard G, Schwalbe H, Kuster B,
ACS Chem Biol. 2016 Oct 21.
DOI: 10.1021/ACSCHEMBIO.6B00709 |
PUBMED: 27768280 | IF(2014) = 5.3
PDB [P13]: 5IA4 5I9W 5I9Y 5I9X 5I9Z 5IA5 5IA1 5I9V
112: The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Dahms SO, Creemers JW, Schaub Y, Bourenkov GP, Zogg T, Brandstetter H, Than ME
Sci Rep. 2016 Sep 27;6:34303.
DOI: 10.1038/SREP34303 |
PUBMED: 27670069 | IF(2015) = 5.23
PDB [P13]: 5JMO
111: Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptorGIF.
Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN
Nat Commun. 2016 Nov 7;7:13228.
DOI: 10.1038/NCOMMS13228 |
PUBMED: 27819269 | IF(2015) = 11.3
PDB [P14]: 5D22 5D28
110: Robotic QM/MM-driven maturation of antibody combining sites.
Smirnov IV, Golovin AV, Chatziefthimiou SD, Stepanova AV, Peng Y, Zolotareva OI, Belogurov AA Jr, Kurkova IN, Ponomarenko NA, Wilmanns M, Blackburn GM, Gabibov AG, Lerner RA
Sci Adv. 2016 Oct 19;2(10):e1501695. eCollection 2016 Oct.
DOI: 10.1126/SCIADV.1501695 |
PUBMED: 27774510 | IF(2018) = 12.5
PDB [P14]: 5TJD 6Y1N 5ADO
109: HU histone-like DNA-binding protein from Thermus thermophilus: structural andevolutionary analyses.
Papageorgiou AC, Adam PS, Stavros P, Nounesis G, Meijers R, Petratos K, Vorgias CE
Extremophiles. 2016 Jun 24.
DOI: 10.1007/S00792-016-0859-1 |
PUBMED: 27342116 | IF(2014) = 2.34
PDB [P14]: 5EKA
108: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
Schrader J, Henneberg F, Mata RA, Tittmann K, Schneider TR, Stark H, Bourenkov G, Chari A
Science. 2016 Aug 5;353(6299):594-8.
DOI: 10.1126/SCIENCE.AAF8993 |
PUBMED: 27493187 | IF(2015) = 34.6
PDB [P14]: 5LE5 5LF1 5LF0 5LF3 5LF4 5LF6 5LF7 5LEX 5LEY 5LEZ
107: Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.
Kasaragod VB, Schindelin H,
Structure. 2016 May 3;24(5):782-8. Epub 2016 Apr 21.
DOI: 10.1016/J.STR.2016.02.023 |
PUBMED: 27112598 | IF(2014) = 5.62
PDB [P13]: 5ERV 5ERU
106: Data collection with a tailored X-ray beam size at 2.69 A wavelength (4.6 keV):sulfur SAD phasing of Cdc23(Nterm).
Cianci M, Groves MR, Barford D, Schneider TR,
Acta Crystallogr D Struct Biol. 2016 Mar 1;72(Pt 3):403-12. Epub 2016 Mar 1.
DOI: 10.1016/j.ijbiomac.2016.02.047 |
PUBMED: 26960127 | IF(2015) = 2.51
PDB [P13]: 5FTP
105: Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase.
Clausen JD, Bublitz M, Arnou B, Olesen C, Andersen JP, Moller JV, Nissen P,
Structure. 2016 Apr 5;24(4):617-23.
DOI: 10.1016/J.STR.2016.02.018 |
PUBMED: 27050689 | IF(2014) = 5.62
PDB [P14]: 5A3Q
104: Molecular basis for inhibition of AcrB multidrug efflux pump by novel andpowerful pyranopyridine derivatives.
Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS, Ding X, Ornik AR, Ruggerone P, Bowlin TL, Nikaido H, Pos KM, Opperman TJ,
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3509-14. Epub 2016 Mar 14.
DOI: 10.1073/PNAS.1602472113 |
PUBMED: 26976576 | IF(2015) = 9.74
PDB [P13]: 5ENT
103: Inactivation of urease by 1,4-benzoquinone: chemistry at the protein surface.
Mazzei L, Cianci M, Musiani F, Ciurli S,
Dalton T. 2016 Apr 7;45(13):5455-9. Epub 2016 Mar10.
DOI: 10.1039/C6DT00652C |
PUBMED: 26961812 | IF(2015) = 4.19
PDB [P13]: 5FSE 5FSD
102: Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases.
Molitor C, Mauracher SG, Rompel A
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1806-15. Epub 2016 Mar 14.
DOI: 10.1073/PNAS.1523575113 |
PUBMED: 26976571 | IF(2015) = 9.74
PDB [P14]: 4Z0Y
101: Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.
Drebes J, Kunz M, Windshugel B, Kikhney AG, Muller IB, Eberle RJ, Oberthur D, Cang H, Svergun DI, Perbandt M, Betzel C, Wrenger C
Sci Rep. 2016 Mar 10;6:22871.
DOI: 10.1038/SREP22871 |
PUBMED: 26960569 | IF(2014) = 5.57
PDB [P14]: 5CGA 5CGE
100: Crystallographic studies of the complex of human HINT1 protein with anon-hydrolyzable analog of Ap4A.
Dolot R, Kaczmarek R, Seda A, Krakowiak A, Baraniak J, Nawrot B
Int J Biol Macromol. 2016 Jun;87:62-9. Epub 2016 Feb 18.
DOI: 10.1016/J.IJBIOMAC.2016.02.047 |
PUBMED: 26905466 | IF(2018) = 4.8
PDB [P13]: 4ZKL
99: Sleeping Beauty transposase structure allows rational design of hyperactivevariants for genetic engineering.
Voigt F, Wiedemann L, Zuliani C, Querques I, Sebe A, Mates L, Izsvak Z, Ivics Z, Barabas O,
Nat Commun. 2016 Mar 30;7:11126.
DOI: 10.1038/NCOMMS11126 |
PUBMED: 27025571 | IF(2014) = 11.4
PDB [P14]: 5CR4
98: Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells.
Berneking L, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney AG, Koch-Nolte F, Buck F, Perbandt M, Betzel C, Svergun DI, Hentschke M, Aepfelbacher M,
PLoS Pathog. 2016 Jun 14;12(6):e1005660. eCollection 2016 Jun.
DOI: 10.1371/journal.ppat.1005660 |
PUBMED: 27300509 | IF(2018) = 6.1
PDB [P14]: 4OW2
97: Impact of the crystallization condition on importin-β conformation. Acta Crystallogr D
Tauchert MJ, Hémonnot C, Neumann P, Köster S, Ficner R, Dickmanns A
Struct Biol. 2016 Jun;72(Pt 6):705-17.
DOI: 10.1107/S2059798316004940 |
PUBMED: 27303791
PDB [P13]: 4XRI 4XRK
96: Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangementfor phosphoryl transfer.
Weisse RH, Faust A, Schmidt M, Schonheit P, Scheidig AJ
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E519-28. Epub 2016 Jan 19.
DOI: 10.1073/PNAS.1518614113 |
PUBMED: 26787904 | IF(2014) = 9.67
PDB [P14]: 5HBR 4YAK 4XYL 4YB8 4YBZ 4XYM
95: Comprehensive Structural Characterization of the Bacterial HomospermidineSynthase-an Essential Enzyme of the Polyamine Metabolism.
Krossa S, Faust A, Ober D, Scheidig AJ,
Sci Rep. 2016 Jan 18;6:19501.
DOI: 10.1038/SREP19501 |
PUBMED: 26776105 | IF(2014) = 5.6
PDB [P14]: 4TVB 4XRG 4XR4 4XQC 4XQE 4XQG
94: Characterization and 1.57 A resolution structure of the key fire blight phosphatase AmsI from Erwinia amylovora.
Salomone-Stagni M, Musiani F, Benini S.
Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):903-910. Epub 2016 Nov 30.
DOI: 10.1107/S2053230X16018781 |
PUBMED: 27917839; | IF(2019) = 0.97
PDB [P13]: 4D74
93: Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants
Stellmacher L, Sandalova T, Schneider S, Schneider G, Sprenger GA, Samland AK
Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):467-76.
DOI: 10.1107/S2059798316001170. Epub 2016 Mar 24. |
PUBMED: 27050126 | IF(2018) = 3.2
PDB [P13]: 4S2B
92: Expression, crystallization and structure elucidation of γ-terpinene synthase from Thymus vulgaris.
Rudolph K, Parthier C, Egerer-Sieber C, Geiger D, Muller YA, Kreis W, Muller-Uri F
Acta Crystallogr F Struct Biol Commun. 2016 Jan 1;72(Pt 1):16-23.
DOI: 10.1107/S2053230X15023043 |
PUBMED: 26750479 | IF(2014) = 0.54
PDB [P13]: 5C05
91: Structure of GPN-loop GTPase Npa3 and implications for RNA polymerase II assembly.
Niesser J,Wagner FR,Kostrewa D,Muhlbacher W,Cramer P
Mol Cell Biol. 2015 Dec 28.
DOI: 10.1128/MCB.01009-15 |
PUBMED: 26711263 | IF(2015) = 4.77
PDB [P13]: 5HCN 5HCI
90: The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs.
Kiliszek A, Banaszak K, Dauter Z, Rypniewski W
Nucleic Acids Res. 2015 Dec 29.
DOI: 10.1093/NAR/GKV1513 |
PUBMED: 26717983 | IF(2015) = 9.12
PDB [P13]: 5EMF
89: Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/IronCofactor.
Griese JJ, Kositzki R, Schrapers P, Branca RM, Nordstrom A, Lehtio J, Haumann M, Hogbom M
J Biol Chem. 2015 Oct 16;290(42):25254-72. Epub2015 Aug 31.
DOI: 10.1016/J.JINORGBIO.2016.04.019 |
PUBMED: 26324712 | IF(2014) = 4.57
PDB [P13]: 5EKB
88: The terminal phycobilisome emitter, LCM: A light-harvesting pigment with aphytochrome chromophore.
Tang K, Ding WL, Hoppner A, Zhao C, Zhang L, Hontani Y, Kennis JT, Gartner W, Scheer H, Zhou M, Zhao KH
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15880-5.
DOI: 10.1073/PNAS.1519177113 |
PUBMED: 26669441 | IF(2014) = 9.67
PDB [P13]: 4XXI
87: The large N-terminal region of the Brr2 RNA helicase guides productivespliceosome activation.
Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Preussner M, Heyd F, Urlaub H, Luhrmann R, Santos KF, Wahl MC
Gene Dev. 2015 Dec 15;29(24):2576-87. Epub 2015 Dec4.
DOI: 10.1101/GAD.271528.115 |
PUBMED: 26637280 | IF(2014) = 12.6
PDB [P14]: 5DCA
86: Structural Insights into the Competitive Binding of Diclofenac and Naproxen by Equine Serum Albumin.
Sekula B, Bujacz A
J Med Chem. 2015 Dec 23.
DOI: 10.1021/ACS.JMEDCHEM.5B00909 |
PUBMED: 26652101 | IF(2014) = 5.4
PDB [P13]: 4ZBQ
85: Structures of yeast peroxisomal Delta(3),Delta(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.
Onwukwe GU, Koski MK, Pihko P, Schmitz W, Wierenga RK
Acta Crystallogr D Biol Crystallogr. 2015 Nov 1;71(Pt 11):2178-91.
DOI: 10.1107/S139900471501559X |
PUBMED: 26527136 | IF(2018) = 3.2
PDB [P13]: 4ZDE 4ZDB
84: Terahertz radiation induces non-thermal structural changes associated with Fröhlich condensation in a protein crystal.
Lundholm IV, Rodilla H, Wahlgren WY, Duelli A, Bourenkov G, Vukusic J, Friedman R, Stake J, Schneider T, Katona G.
Struct Dyn (2015 Sep)2:054702
DOI: 10.1063/1.4931825 |
PUBMED: 26798828
PDB [P14]: 5APC 5APE 5APD 5APF
83: DETERMINANTS OF LIGAND BINDING AND ACTIVITY IN CNPASE
A.RAASAKKA,M.MYLLYKOSKI,M.LEHTIMAKI,P.KURSULA
Sci Rep. 2015 Nov 13;5:16520.
DOI: 10.1038/srep16520 |
PUBMED: 26563764 | IF(2014) = 5.6
PDB [P14]: 4WC9 4WDH 4WEX 4WDF 4WDG 4WDA 4WDB 4WBL
82: Kinetic and structural studies reveal a unique binding mode of sulfite to thenickel center in urease.
Mazzei L,Cianci M,Benini S,Bertini L,Musiani F,Ciurli S
J Inorg Biochem. 2015 Nov 5;154:42-49.
DOI: 10.1016/J.JINORGBIO.2015.11.003 |
PUBMED: 26580226
PDB [P13]: 5A6T
81: Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of NaturalPolyphenols and their Metabolites.
Florio P, Folli C, Cianci M,Del Rio D,Zanotti G,Berni R
J Biol Chem. 2015 Oct 14.
DOI: 10.1074/JBC.M115.690172 |
PUBMED: 26468275 | IF(2018) = 4.1
PDB [P13]: 5AL8 5AKS 5AKT 5AKV
80: Open and closed states of Candida antarctica Lipase B: protonation and themechanism of interfacial activation.
Stauch B, Fisher SJ, Cianci M
J Lipid Res. 2015 Oct 7.
DOI: 10.1194/JLR.M063388 |
PUBMED: 26447231
PDB [P13]: 5A6V 5A71
79: Structural studies of Helix aspersa agglutinin complexed with GalNAc: A lectin that serves as a diagnostic tool.
Pietrzyk AJ, Bujacz A, Mak P, Potempa B, Niedziela T
Int J Biol Macromol. 2015 Sep 28;81:1059-1068.
DOI: 10.1016/J.IJBIOMAC.2015.09.044 |
PUBMED: 26416237 | IF(2018) = 4.8
PDB [P13]: 4Q56
78: Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.
Luhavaya H, Dias MV, Williams SR, Hong H, de Oliveira LG, Leadlay PF
Angew Chem Int Ed Engl. 2015 Sep 17.
DOI: 10.1002/ANIE.201507090 |
PUBMED: 26377145 | IF(2019) = 13.0
PDB [P13]: 5CXO
77: Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1).
Karna N, Legowska A, Malicki S, Debowski D, Golik P, Gitlin A, Grudnik P, Wladyka B, Brzozowski K, Dubin G, Rolka K
ChemBioChem. 2015 Jul 25.
DOI: 10.1002/CBIC.201500296 |
PUBMED: 26212347 | IF(2014) = 3.0
PDB [P13]: 4XOJ
76: Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.
Oberthur D, Achenbach J, Gabdulkhakov A, Buchner K, Maasch C, Falke S, Rehders D, Klussmann S, Betzel C
Nat Commun. 2015 Apr 22;6:6923.
DOI: 10.1038/ncomms7923 |
PUBMED: 25901662 | IF(2014) = 11.4
PDB [P13]: 4R8I
75: Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry.
Zubriene A, Smirnoviene J, Smirnov A, Morkunaite V, Michailoviene V, Jachno J, Juozapaitiene V, Norvaisas P, Manakova E, Grazulis S, Matulis D
Biophys Chem. 2015 Oct;205:51-65.
DOI: 10.1016/J.BPC.2015.05.009 |
PUBMED: 26079542
PDB [P14]: 4WUP 4WR7 4WW8 4WW6 4WUQ
74: Two independently folding units of Plasmodium profilin suggest evolution via genefusion.
Bhargav SP,Vahokoski J,Kallio JP,Torda AE,Kursula P,Kursula I
Cell Mol Life Sci. 2015 May 27.
DOI: 10.1007/s00018-015-1932-0 |
PUBMED: 26012696 | IF(2018) = 7.0
PDB [P13]: 4D60
73: 3-Sulfinopropionyl-coenzyme A (3SP-CoA) desulfinase from Advenellamimigardefordensis DPN7(T): crystal structure and function of a desulfinase with an acyl-CoA dehydrogenase fold.
Schurmann M, Meijers R, Schneider TR, Steinbuchel A, Cianci M
Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1360-72. Epub 2015 May 23.
DOI: 10.1107/S1399004715006616 |
PUBMED: 26057676 | IF(2018) = 3.2
PDB [P13]: 5AF7 5AHS
72: High resolution structures of Plasmodium falciparum GST complexes provide novelinsights into the dimer-tetramer transition and a novel ligand-binding site.
Perbandt M,Eberle R,Fischer-Riepe L,Cang H,Liebau E,Betzel C
J Struct Biol. 2015 Sep;191(3):365-75. Epub 2015 Jun 10.
DOI: 10.1016/J.JSB.2015.06.008 |
PUBMED: 26072058 | IF(2018) = 3.8
PDB [P14]: 4ZXG
71: Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Simdomain from the Hypoxia-inducible factor 3alpha.
Fala AM, Oliveira JF, Adamoski D, Aricetti JA, Dias MM, Dias MV, Sforca ML, Lopes-de-Oliveira PS, Rocco SA, Caldana C, Dias SM, Ambrosio AL
Sci Rep. 2015 Aug 3;5:12698.
DOI: 10.1038/SREP12698 |
PUBMED: 26237540 | IF(2014) = 5.6
PDB [P13]: 4WN5
70: Fragment Binding Can Be Either More Enthalpy-Driven or Entropy-Driven: CrystalStructures and Residual Hydration Patterns Suggest Why.
Ruhmann E, Betz M, Heine A, Klebe G
J Med Chem. 2015 Sep 10;58(17):6960-71. Epub2015 Aug 24.
DOI: 10.1021/ACS.JMEDCHEM.5B00812 |
PUBMED: 26270568 | IF(2014) = 5.5
PDB [P14]: 4UDW 5AHG 5AF9 4UD9
69: Functionalization of fluorinated benzenesulfonamides and their inhibitoryproperties toward carbonic anhydrases.
Dudutiene V, Zubriene A, Smirnov A, Timm DD, Smirnoviene J, Kazokaite J, Michailoviene V, Zaksauskas A, Manakova E, Grazulis S, Matulis D
ChemMedChem. 2015 Apr;10(4):662-87.
DOI: 10.1002/CMDC.201402490 |
PUBMED: 25758852 | IF(2018) = 3.0
PDB [P13]: 4QIY 4QJ0 4QIZ 4QJP
68: Structural basis of GD2 ganglioside and mimetic peptide recognition by 14G2aantibody.
Horwacik I, Golik P, Grudnik P, Kolinski M, Zdzalik M, Rokita H, Dubin G
Mol Cell Proteomics. 2015 Jul 15.
DOI: 10.1074/mcp.M115.052720 |
PUBMED: 26179345 | IF(2018) = 4.8
PDB [P14]: 4TUK 4TUO 4TUL 4TRP
67: Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanningprotein A (DisA) and its inhibition by 3'-dATP.
Muller M, Deimling T, Hopfner KP, Witte G
Biochem J. 2015 Aug 1;469(3):367-74. Epub 2015 May 27.
DOI: 10.1042/BJ20150373 |
PUBMED: 26014055
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66: Natural flavonoids as antidiabetic agents. The binding of gallic and ellagicacids to glycogen phosphorylase b.
Kyriakis E, Stravodimos GA, Kantsadi AL, Chatzileontiadou DS, Skamnaki VT, Leonidas DD
FEBS Lett. 2015 Jul 8;589(15):1787-94. Epub2015 May 14.
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PUBMED: 25980608 | IF(2018) = 2.7
PDB [P14]: 4Z5X
65: Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly.
Male G, von Appen A, Glatt S, Taylor NM, Cristovao M, Groetsch H, Beck M, Muller CW
Nat Commun. 2015 Jun 10;6:7387.
DOI: 10.1038/NCOMMS8387 |
PUBMED: 26060179 | IF(2014) = 11.4
PDB [P14]: 5AIO
64: The crystal structure of Erwinia amylovora levansucrase provides a snapshot ofthe products of sucrose hydrolysis trapped into the active site.
Wuerges J, Caputi L, Cianci M, Boivin S, Meijers R, Benini S
J Struct Biol. 2015 Sep;191(3):290-8.
DOI: 10.1016/J.JSB.2015.07.010 |
PUBMED: 26208466 | IF(2018) = 3.8
PDB [P13]: 4D47
63: IGG FAB FRAGMENT CRYSTAL FORM 1/2
R.K.JENSEN, G.R.ANDERSEN
Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):419-26
DOI: 10.1107/S2053230X15004100 |
PUBMED: 25849503 | IF(2019) = 0.97
PDB [P14]: 4X7T 4X7S
62: A covalent homodimer probing early oligomers along amyloid aggregation.
Halabelian L, Relini A, Barbiroli A, Penco A, Bolognesi M, Ricagno S
Sci Rep. 2015 Sep 30;5:14651.
DOI: 10.1038/srep14651 |
PUBMED: 26420657 | IF(2014) = 5.6
PDB [P14]: 4RA3
61: Structural Elucidation of the Bispecificity of A Domains as a Basis forActivating Non-natural Amino Acids.
Kaljunen H, Schiefelbein SH, Stummer D, Kozak S, Meijers R, Christiansen G, Rentmeister A
Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8833-6.
DOI: 10.1002/ANGE.201503275 |
PUBMED: 26096082 | IF(2014) = 11.6
PDB [P14]: 4D4I 4D4H 4D4G 4D56 4D57
60: Tracing binding modes in hit-to-lead optimization: chameleon-like poses ofaspartic protease inhibitors.
Kuhnert M, Koster H, Bartholomaus R, Park AY, Shahim A, Heine A, Steuber H, Klebe G, Diederich WE
Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2849-53.
DOI: 10.1002/ANIE.201411206 |
PUBMED: 25630461 | IF(2014) = 11.6
PDB [P14]: 3WZ6
59: Structural Hot Spots Determine Functional Diversity of the Candida glabrataEpithelial Adhesin Family.
Diderrich R, Kock M, Maestre-Reyna M, Keller P, Steuber H, Rupp S, Essen LO, Mosch HU
J Biol Chem. 2015 Aug 7;290(32):19597-613.
DOI: 10.1074/jbc.M115.655654 |
PUBMED: 26105055 | IF(2018) = 4.1
PDB [P14]: 4COZ 4COW
58: Structure-Based Enzyme Tailoring of 5-Hydroxymethylfurfural Oxidase
Dijkman WP, Binda C, Fraaije MW, Mattevi A
ACS Catalysis. 5: 1833 (2015)
DOI: 10.1021/ACSCATAL.5B00031 |
PUBMED: NONE | IF(2018) = 12.1
PDB [P13]: 4UDP
57: Thiosulfate dehydrogenase (TsdA) from Allochromatium vinosum: structural andfunctional insights into thiosulfate oxidation.
Brito JA, Denkmann K, Pereira IA, Archer M, Dahl C
J Biol Chem. 2015 Apr 3;290(14):9222-38.
DOI: 10.1074/JBC.M114.623397 |
PUBMED: 25673691 | IF(2018) = 4.1
PDB [P14]: 4WQ8 4WQ9
56: Structural and biochemical analysis of the essential diadenylate cyclase CdaAfrom Listeria monocytogenes.
Rosenberg J, Dickmanns A, Neumann P, Gunka K, Arens J, Kaever V, Stulke J, Ficner R, Commichau FM
J Biol Chem. 2015 Mar 6;290(10):6596-606.
DOI: 10.1074/jbc.M114.630418 |
PUBMED: 25605729 | IF(2018) = 4.1
PDB [P13]: 4RV7
55: Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2.
Glatt S, Zabel R, Vonkova I, Kumar A, Netz DJ, Pierik AJ, Rybin V, Lill R, Gavin AC, Balbach J, Breunig KD, Muller CW.
Structure. 2015 Jan 6;23(1):149-60
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PUBMED: 25543256 | IF(2014) = 6.8
PDB [P14]: 4D4O 4D4P
54: Detailed structure-function correlations of Bacillus subtilis acetolactatesynthase.
Sommer B, von Moeller H, Haack M, Qoura F, Langner C, Bourenkov G, Garbe D, Loll B, Bruck T
ChemBioChem. 2015 Jan 2;16(1):110-8.
DOI: 10.1002/cbic.201402541 |
PUBMED: 25393087 | IF(3.1) = 2.6
PDB [P14]: 4RJK
53: Crystal structure of Bombyx mori lipoprotein 6: comparative structural analysis of the 30-kDa lipoprotein family
Pietrzyk AJ, Bujacz A, Lochynska M, Jaskolski M, Bujacz G
PLoS One. 2014 Nov 7;9(11):e108761
DOI: 10.1371/JOURNAL.PONE.0108761 |
PUBMED: 25379889 | IF(2018) = 2.8
PDB [P14]: 4PC4
52: Discovery and characterization of novel selective inhibitors of carbonicanhydrase IX.
Dudutiene V, Matuliene J, Smirnov A, Timm DD, Zubriene A, Baranauskiene L, Morkunaite V, Smirnoviene J, Michailoviene V, Juozapaitiene V, Mickeviciute A, Kazokaite J, Baksyte S, Kasiliauskaite A, Jachno J, Revuckiene J, Kisonaite M, Pilipuityte V, Ivanauskaite E, Milinaviciute G, Smirnovas V, Petrikaite V, Kairys V, Petrauskas V, Norvaisas P, Linge D, Gibieza P, Capkauskaite E, Zaksauskas A, Kazlauskas E, Manakova E, Grazulis S, Ladbury JE, Matulis D
J Med Chem. 2014 Nov 26;57(22):9435-46.
DOI: 10.1021/JM501003K |
PUBMED: 25358084 | IF(2014) = 5.4
PDB [P13]: 4Q07 4PZH 4Q06 4Q09 4Q08
51: Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Tamulaitiene G, Silanskas A, Grazulis S, Zaremba M, Siksnys V.
Nucleic Acids Res. 2014 Dec 16;42(22):14022-30.
DOI: 10.1093/NAR/GKU1237 |
PUBMED: 25429979 | IF(2018) = 11.1
PDB [P13]: 4RD5
50: Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin.
Grudnik P, Debowski D, Legowska A, Malicki S, Golik P, Karna N, Rolka K, Dubin G.
Proteins. 2014 Dec 24.
DOI: 10.1002/PROT.24750 |
PUBMED: 25546528 | IF(2014) = 2.9
PDB [P13]: 4U2W
49: 4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.
Rutkauskas K, Zubriene A, Tumosiene I, Kantminiene K, Kazemekaite M, Smirnov A, Kazokaite J, Morkunaite V, Capkauskaite E, Manakova E, Grazulis S, Beresnevicius ZJ, Matulis D
Molecules (2014) 19: 17356-17380
DOI: 10.3390/MOLECULES191117356 |
PUBMED: 25353386 | IF(2020) = 3.3
PDB [P13]: 4Q6E 4Q6D
48: Schulz EC, Barabas O
Structure of an Escherichia coli Hfq:RNA complex at 0.97 A resolution.
Acta Crystallogr Sect F. (2014) 70: 1492-1497
DOI: 10.1107/S2053230X14020044 |
PUBMED: 25372815 | IF(2019) = 0.97
PDB [P13]: 4PNO
47: Das, U., Pogenberg, V., Tiruttani Subhramanyam, U.K., Wilmanns, M., Gourinath, S., Srinivasan, A.
Crystal Structure of the Vapbc-15 Complex from Mycobacterium Tuberculosis Reveals a Two-Metal Ion Dependent Pin-Domain Ribonuclease And a Variable Mode of Toxin-Antitoxin Assembly
J Struct Biol. (2014) 188:249-258
DOI: 10.1016/J.JSB.2014.10.002 |
PUBMED: 25450593 | IF(2014) = 3.4
PDB [P13]: 4CHG
46: Crystal structure of the rigor-like human non-muscle myosin-2 motor domain.
Munnich S,Pathan-Chhatbar S,Manstein DJ
FEBS Lett. 2014 Dec 20;588(24):4754-60.
DOI: 10.1016/j.febslet.2014.11.007 |
PUBMED: 25451231 | IF(2018) = 2.7
PDB [P14]: 4PD3
45: Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress.
Chaves-Sanjuan A, Sanchez-Barrena MJ, Gonzalez-Rubio JM, Moreno M, Ragel P, Jimenez M, Pardo JM, Martinez-Ripoll M, Quintero FJ, Albert A.
Proc Natl Acad Sci U S A. (2014) Oct 6.
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PUBMED: 25288725 | IF(2014) = 9.6
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44: Sainz-Polo MA, Valenzuela SV, Gonzále B, Pastor F2, Sanz-Aparicio J.
Structural analysis of glucuronoxylan specific Xyn30D and its attached CBM35 domain give insights into the role of modularity in specificity
J Biol Chem. 2014 Sep 8.
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PUBMED: 25202007 | IF(2018) = 4.1
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43: Kuhle B, Ficner R.
A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
EMBO J. 2014 Sep 15.
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42: Liu Y, Neumann P, Kuhle B, Monecke T, Schell S, Chari A, Ficner R.
Translation initiation factor eIF3b contains a nine-bladed β-propeller and interacts with the 40S ribosomal subunit.
Structure. 2014 Jun 10;22(6):923-30
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PUBMED: 24768115 | IF(2013) = 5.3
PDB [P13]: 4NOX
41: Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HD, Svergun DI, Zhang Y, Wang JH, Meijers R.
The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue.
Neuron. 2014 Aug 20;83(4):839-49
DOI: 10.1016/J.NEURON.2014.07.010 |
PUBMED: 25123307 | IF(2013) = 16.5
PDB [P14]: 4URT
40: Benini S, Cianci M, Mazzei L, Ciurli S.
Fluoride inhibition of Sporosarcina pasteurii urease: structure and thermodynamics.
J Biol Inorg Chem. 2014 epub
DOI: 10.1007/S00775-014-1182-X |
PUBMED: 25113581 | IF(2018) = 3.6
PDB [P13]: 4CEU 4CEX
39: Salamun J, Kallio JP, Daher W, Soldati-Favre D, Kursula I.
Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress.
FASEB J. 2014 Aug 11.
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PDB [P14]: 4OZU
38: Prokofev, I.I., Lashkov, A.A., Gabdoulkhakov, A.G., Dontsova, M.V., Seregina, T.A., Mironov, A.S., Betzel, C., Mikhailov, A.M.
Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil
Acta Crystallogr Sect F. 70: 60-63 (2014)
DOI: 10.1107/S2053230X13031877 |
PUBMED: 24419619 | IF(2019) = 0.97
PDB [P13]: 4K6O
37: Dunne M, Mertens HD, Garefalaki V, Jeffries CM, Thompson A, Lemke EA, Svergun DI, Mayer MJ, Narbad A, Meijers R.
The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor.
PLoS Pathog. 2014 Jul 24;10(7):e1004228.
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PUBMED: 25058163 | IF(2013) = 8.7
PDB [P14]: 4CU2
36: Sauter, A., Oelker, M., Zocher, G., Zhang, F., Stehle, T., Schreiber, F.
Non-Classical Pathways of Protein Crystallization in the Presence of Multivalent Metal Ions
Cryst Growth Des. 2014, 14, 12, 6357-6366
DOI: 10.1021/cg501099d |
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35: Wen Y, Behiels E, Felix J, Elegheert J, Vergauwen B, Devreese B, Savvides SN.
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Res. 2014 Nov 1;42(15):10134-47
DOI: 10.1093/nar/gku665 |
PUBMED: 25056321 | IF(2018) = 11.1
PDB [P13]: 4PU4 4PU5 4PU7 4PU8
34: Specific binding of gibberellic acid by Cytokinin-Specific Binding Proteins: a new aspect of plant hormone-binding proteins with the PR-10 fold.
Ruszkowski M, Sliwiak J, Ciesielska A, Barciszewski J, Sikorski M, Jaskolski M.
Acta Crystallogr Sect D. 70: 2032-2041 (2014)
DOI: 10.1107/S1399004714010578 |
PUBMED: 25004979 | IF(2018) = 3.2
PDB [P14]: 4PSB
33: Chasing Protons: How Isothermal Titration Calorimetry, Mutagenesis, and pKa Calculations Trace the Locus of Charge in Ligand Binding to a tRNA-Binding Enzyme.
Neeb M1, Czodrowski P, Heine A, Barandun LJ, Hohn C, Diederich F, Klebe G.
J Med Chem. 2014 Jul 10;57(13):5554-65.
DOI: 10.1021/jm500401x |
PUBMED: 24955548 | IF(2018) = 6.1
PDB [P14]: 4PUN 4PUM 4PUL
32: Kuhle, B., Ficner, R.
eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
EMBO J. 33:1177-91 (2014).
DOI: 10.1002/embj.201387344 |
PUBMED: 24686316 | IF(2018) = 11.2
PDB [P13]: 4N3N 4N3G 4NCL 4N3S 4NCF
31: Bjerregaard-Andersen, K., Sommer, T., Jensen, J.K., Jochimsen, B., Etzerodt, M., Morth, J.P.
A proton wire and water channel revealed in the crystal structure of isatin hydrolase
J Biol Chem. 2014 Jun 10.
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PUBMED: 24917679 | IF(2018) = 4.1
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30: Janke, R., Goerner, C., Hirte, M., Brueck, T., Loll, B
The first structure of a bacterial diterpene cyclase: CotB2
Acta Crystallogr Sect D. D70 (2014)
DOI: 10.1107/S1399004714005513 |
PUBMED: 24914964 | IF(2018) = 3.2
PDB [P14]: 4OMH 4OMG
29: Mierzejewska, K., Siwek, W., Czapinska, H., Skowronek, K., Bujnicki, J.M., Bochtler, M.
Structural basis of the methylation specificity of R.DpnI.
Nucleic Acids Res. 42: 8745-8754 (2014)
DOI: 10.1093/nar/gku546 |
PUBMED: 24966351 | IF(2018) = 11.1
PDB [P14]: 4KYW
28: Espina, G., Eley, K., Pompidor, G., Schneider, T.R., Crennell, S.J., Danson, M.J.
A novel β-xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds.
Acta Crystallogr Sect D. 70: 1366 (2014)
DOI: 10.1107/S1399004714002788 |
PUBMED: 24816105 | IF(2018) = 3.2
PDB [P13]: 4C1O
27: Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping.
Han H, Kursula P.
J Biol Chem (2014 May)289:14121-14131
DOI: 10.1074/jbc.M114.554816 |
PUBMED: 24675079 | IF(2018) = 4.1
PDB [P13]: 4CMZ 4CN0
26: Kazrani, A.A., Kowalska, M., Czapinska, H., Bochtler, M.
Crystal structure of the 5hmC specific endonuclease PvuRts1I
Nucleic Acids Res. 2014 Mar 25. [Epub ahead of print]
DOI: 10.1093/nar/gku186 |
PUBMED: 24634440 | IF(2018) = 11.1
PDB [P13]: 4OQ2
25: Structural basis of the proinflammatory signaling complex mediated by TSLP
Verstraete, K, van Schie, L, Vyncke, L, Bloch, Y, Tavernier, J, Pauwels, E, Peelman, F, Savvides, SN
Nat Struct Mol Biol. 2014 Apr;21(4):375-82.
DOI: 10.1038/nsmb.2794 |
PUBMED: 24632570 | IF(2013) = 11.6
PDB [P13]: 4NN5 4NN6 4NN7
24: Crystal structures of two tetrameric β-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora.
Lehneck R, Neumann P, Vullo D, Elleuche S, Supuran CT, Ficner R, Pöggeler S.
FEBS J. 2014 Apr;281(7):1759-72.
DOI: 10.1111/febs.12738 |
PUBMED: 24506675 | IF(2018) = 4.7
PDB [P13]: 4O1K
23: Role of kappa -> lambda light-chain constant-domain switch in the structure and functionality of A17 reactibody
N. Ponomarenko, S. D. Chatziefthimiou, I. Kurkova, Yu. Mokrushina, Y. Mokrushina, A. Stepanova, I. Smirnov, M. Avakyan, T. Bobik, A. Mamedov, V. Mitkevich, A. Belogurov Jr, O. S. Fedorova, M. Dubina, A. Golovin, V. Lamzin, A. Friboulet, A. A. Makarov, M. Wilmanns and A. Gabibov
Acta Crystallogr D Biol Crystallogr. (2014) D70:708-719
DOI: 10.1107/S1399004713032446 |
PUBMED: 24598740 | IF(2018) = 3.2
PDB [P14]: 3ZL4
22: Structural Basis for Binding of Fluorinated Glucose and Galactose to Trametes multicolor Pyranose 2-Oxidase Variants with Improved Galactose Conversion
Tan TC, Spadiut O, Gandini R, Haltrich D, Divne C.
PLoS One. 2014; 9(1): e86736
DOI: 10.1371/journal.pone.0086736 |
PUBMED: 24466218 | IF(2018) = 2.8
PDB [P13]: 4MOG 4MOI 4MOR
21: Serial crystallography on in vivo-grown microcrystals using synchrotron radiation
Gati, C., Bourenkov, G., Klinge, M., Rehders, D., Stellato, F., Oberthuer, D., Yefanov, O., Sommer, B.P., Mogk, S., Duszenko, M. et al. (2014).
IUCrJ. (2014) 1 87-94
DOI: 10.1107/S2052252513033939 |
PUBMED: 25075324 | IF(2020) = 4
PDB [P14]: 4N4Z
20: Resolving the activation site of positive regulators in plant phosphoenolpyruvate carboxylase.
Schlieper D, Förster, K, Paulus JK, Groth G
Mol Plant. 7:437-40 (2014)
DOI: 10.1093/mp/sst130 |
PUBMED: 24043710 | IF(2019) = 10.8
PDB [P14]: 4BXC
19: CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis.
Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T.
Cell. 155:647 (2013).
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PUBMED: 24243021 | IF(2018) = 36.2
PDB [P14]: 4C2G
18: Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII
Capkauskaite E, Zubriene A, Smirnov A, Torresan J, Kišonaie M, Kazokaite J, Gylyte J, Michailoviene V, Jogaite V, Manakova E, Gražulis S, Tumkevcius S, Matulis D.
Bioorg Med Chem. 21:6937-6947 (2013)
DOI: 10.1016/j.bmc.2013.09.029 |
PUBMED: 24103428 | IF(2018) = 2.5
PDB [P14]: 4KNN 4KP5
17: The landscape of cytokinin binding by a plant nodulin.
Ruszkowski M, Szpotkowski K, Sikorski M, Jaskolski M.
Acta Crystallogr D Biol Crystallogr. (2013) 69:2365-80
DOI: 10.1107/S0907444913021975 |
PUBMED: 24311578 | IF(2018) = 3.2
PDB [P14]: 4GY9
16: Crystal structure of the 14-subunit RNA polymerase I
Fernandez-Tornero C, Moreno-Morcillo M, Rashid UJ, Taylor NM, Ruiz FM, Gruene T, Legrand P, Steuerwald U, Mueller CW.
Nature. 502:644 (2013)
DOI: 10.1038/nature12636 |
PUBMED: 24153184 | IF(2018) = 43.1
PDB [P14]: 4C3I
15: Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency
Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE.
PLoS Pathog. 9(10):e1003673 (2013)
DOI: 10.1371/journal.ppat.1003673 |
PUBMED: 24146618 | IF(2018) = 6.1
PDB [P14]: 4BLG
14: Iron Binding at Specific Sites within the Octameric HbpS Protects Streptomycetes from Iron-Mediated Oxidative Stress.
Wedderhoff I, Kursula I, Groves MR, Ortiz de Orué Lucana .
PLoS One. 2013 Aug 27;8(8):e71579.
DOI: 10.1371/journal.pone.0071579 |
PUBMED: 24013686 | IF(2018) = 2.8
PDB [P13]: 4BMW
13: Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus.
Coronado MA, Gabdulkhakov A, Georgieva D, Sankaran B, Murakami MT, Arni RK, Betzel C.
Acta Crystallogr D Biol Crystallogr. D69:1958-64 (2013)
DOI: 10.1107/S0907444913018003 |
PUBMED: 24100315 | IF(2018) = 3.2
PDB [P14]: 4GV5
12: Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
Punekar AS, Liljeruhm J, Shepherd TR, Forster AC, Selmer M.
Nucleic Acids Res. 41(20):9537-48 (2013)
DOI: 10.1093/nar/gkt719 |
PUBMED: 23945937 | IF(2018) = 11.1
PDB [P13]: 4BLW
11: Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.
Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA.
Nucleic Acids Res. 2013 41(11):5912
DOI: 10.1093/nar/gkt268 |
PUBMED: 23595147 | IF(2018) = 11.1
PDB [P14]: 3ZLA
10: The hepatitis B virus preS1 domain hijacks host trafficking proteins by motif mimicry.
Jürgens MC, Vürüs J, Rautureau GJ, Shepherd DA, Pye VE, Muldoon J, Johnson CM, Ashcroft AE, Freund SM, Ferguson N.
Nat Chem Biol. 2013 Sep;9(9):540-7.
DOI: 10.1038/nchembio.1294. |
PUBMED: 23851574 | IF(2013) = 13.2
PDB [P14]: 3ZHF
9: Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family
Myllykoski M, Raasakka A, Lehtimäki M, Han H, Kursula I, Kursula P.
J Mol Biol. 425:4307-22 (2013)
DOI: 10.1016/j.jmb.2013.06.012 |
PUBMED: 23831225 | IF(2018) = 5.1
PDB [P14]: 2YPC
8: Structural mechanism of cytosolic DNA sensing by cGAS.
Civril F, Deimling T, de Oliveira Mann C C, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner K P
Nature. 2013 498:332-337
DOI: 10.1038/nature12305 |
PUBMED: 23722159 | IF(2014) = 41.4
PDB [P14]: 4KB6
7: Cloning, expression, purification, crystallization and preliminary X-ray analysis of EaLsc, a levansucrase from Erwinia amylovora
Caputi L, Cianci M, Benini S
Acta Crystallogr F Struct Biol Commun. F69:570-573 (2013)
DOI: 10.1107/S1744309113010750 |
PUBMED: 23695580 | IF(2019) = 0.97
PDB [P13]:
6: Greater efficiency of photosynthetic carbon fixation due to single amino-acid substitution.
Paulus JK, Schlieper D, Groth G.
Nat Commun. 4:1518 (2013)
DOI: 10.1038/ncomms2504 |
PUBMED: 23443546 | IF(2013) = 10.2
PDB [P14]: 3ZGB
5: The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design
Benini S, Kosikowska P, Cianci M, Mazzei L, Vara AG, Berlicki , Ciurli S
J Biol Inorg Chem. 2013 Mar;18(3):391-9.
DOI: 10.1007/s00775-013-0983-7 |
PUBMED: 23412551 | IF(2018) = 3.6
PDB [P14]: 4AC7
4: A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.
Malvezzi F, Litos G, Schleiffer A, Heuck A, Mechtler K, Clausen T, Westermann S.
EMBO J. 2013 Feb 6;32(3):409-23.
DOI: 10.1038/emboj.2012.356 |
PUBMED: 23334295 | IF(2018) = 11.2
PDB [P14]: 4GEQ
3: Structural basis for cooperativity of CRM1 export complex formation.
Monecke T, Haselbach D, VoßB, Russek A, Neumann P, Thomson E, Hurt E, Zachariae U, Stark H, Grubmüller H, Dickmanns A, Ficner R.
Proc Natl Acad Sci U S A. 2012 Dec 31. [Epub ahead of print]
DOI: 10.1073/pnas.1215214110 |
PUBMED: 23277578 | IF(2019) = 9.4
PDB [P14]: 4HZK
2: Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
Santos KF, Jovin SM, Weber G, Pena V, Lührmann R, Wahl MC
Proc Natl Acad Sci U S A. (2012) Oct 23;109(43):17418-23. Epub 2012 Oct 8.
DOI: 10.1073/nas.1208098109 |
PUBMED: 23045696 | IF(2019) = 9.4
PDB [P14]: 4F91
1: Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.
Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slättegård R, Hernalsteens JP, Wyns L, Oscarson S, De Greve H, Hultgren S, Bouckaert J.
PLoS One (2008 Apr)3:e2040
DOI: 10.1371/journal.pone.0002040 |
PUBMED: 18446213 | IF(2018) = 2.8
PDB [P14]: 7QUO