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Philipp Heuser - Research Interests

Postdoc
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The main focus of Philipp Heusers research is on the development of methods for the interpretation of very low resolution macromolecular density data. Therefore sophisticated pattern recognition methods, e.g. based on 3rd order moment invariants or distance matrices are employed.

On the one hand these investigations aim at novel algorithms for the placing of known 3D structures into very low-resolution density maps (i.e. 6-20Å). The main advance of the new software will be, that it does require only a minimum of prior knowledge. It does not require any symmetry of the molecule under investigation, nor a segmentation of the map, nor a prior placement of the domains in the map.

On the other hand the possibilities to interpret such low resolution maps without knowing anything about the molcules in advance are exploited. Based on a number of features the low-resolution density is analysed for patterns of density variation that complies with known patterns from the PDB. Based on the congruence of patterns in the density maps and in the known data from the databases a model of the molecule is built, which in case of x-ray maps can also be used for the extension and improvement of the phases (cmp. Heuser et al. 2009).

Further research interests include the development of predictive methods for structural biology, e.g. for protein structure prediction and for the prediction of the quaternary structure of protein complexes (protein-protein docking).



Publications

Interpretation of very low resolution X-ray electron-density maps using core objects.
Heuser P, Langer GG, Lamzin VS
Acta Crystallogr D Biol Crystallogr. 2009 Jul;65(Pt 7):690-6. Epub 2009 Jun 20.   PUBMED

Efficient methods for filtering and ranking fragments for the prediction of structurally variable regions in proteins.
Heuser P, Wohlfahrt G, Schomburg D
Proteins. 2004 Feb 15;54(3):583-95.   PUBMED

Combination of scoring schemes for protein docking.
Heuser P, Schomburg D
BMC Bioinformatics. 2007 Aug 1;8:279.   PUBMED

Refinement of unbound protein docking studies using biological knowledge.
Heuser P, Bau D, Benkert P, Schomburg D
Proteins. 2005 Dec 1;61(4):1059-67.   PUBMED

Optimised amino acid specific weighting factors for unbound protein docking.
Heuser P, Schomburg D
BMC Bioinformatics. 2006 Jul 14;7:344.   PUBMED

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