EMBL Hamburg, Notkestraße 85, 22607 Hamburg, Germany
Biography
PhD 2009, International Institute of Molecular and Cell Biology, Warsaw, Poland.
Postdoctoral researcher at “Sapienza” University, Rome, Italy.
Postdoctoral researcher at EMBL Heidelberg.
Group leader at EMBL Hamburg since 2017.
Publications
Total: 38 publication(s)
2020
Vorländer MK, Jungblut A, Karius K, Baudin F, Grötsch H, Kosinski J, Müller CW. (2020)
Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation.
Nat Commun 11(1) doi: 10.1038/s41467-020-18707-y
Europe PMC | doi
Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Löw C. (2020)
Structural role of essential light chains in the apicomplexan glideosome.
Commun Biol 3(1) doi: 10.1038/s42003-020-01283-8
Europe PMC | doi
Allegretti M, Zimmerli CE, Rantos V, Wilfling F, Ronchi P, Fung HKH, Lee CW, Hagen W, Turoňová B, Karius K, Börmel M, Zhang X, Müller CW, Schwab Y, Mahamid J, Pfander B, Kosinski J, Beck M. (2020)
In-cell architecture of the nuclear pore and snapshots of its turnover.
Nature 586(7831):796-800. doi: 10.1038/s41586-020-2670-5
Europe PMC | doi
2019
Dauden MI, Jaciuk M, Weis F, Lin TY, Kleindienst C, Abbassi NEH, Khatter H, Krutyhołowa R, Breunig KD, Kosinski J, Müller CW, Glatt S. (2019)
Molecular basis of tRNA recognition by the Elongator complex.
Sci Adv 5(7) doi: 10.1126/sciadv.aaw2326
Europe PMC | doi
Ural-Blimke Y, Flayhan A, Strauss J, Rantos V, Bartels K, Nielsen R, Pardon E, Steyaert J, Kosinski J, Quistgaard EM, Low C. (2019)
Structure of prototypic peptide transporter DtpA from E. coli in complex with valganciclovir provides insights into drug binding of human PepT1.
J. Am. Chem. Soc. 141(6):2404-2412. doi: 10.1021/jacs.8b11343
Europe PMC | doi
2018
Beck M, Mosalaganti S, Kosinski J. (2018)
From the resolution revolution to evolution: structural insights into the evolutionary relationships between vesicle coats and the nuclear pore.
Curr. Opin. Struct. Biol. 52:32-40. doi: 10.1016/j.sbi.2018.07.012
Europe PMC | doi
Mosalaganti S, Kosinski J, Albert S, Schaffer M, Strenkert D, Salomé PA, Merchant SS, Plitzko JM, Baumeister W, Engel BD, Beck M. (2018)
In situ architecture of the algal nuclear pore complex.
Nat Commun 9(1) doi: 10.1038/s41467-018-04739-y
Europe PMC | doi
Mathieson T, Franken H, Kosinski J, Kurzawa N, Zinn N, Sweetman G, Poeckel D, Ratnu VS, Schramm M, Becher I, Steidel M, Noh KM, Bergamini G, Beck M, Bantscheff M, Savitski MM. (2018)
Systematic analysis of protein turnover in primary cells.
Nat Commun 9(1):689. doi: 10.1038/s41467-018-03106-1
Europe PMC | doi
2017
Teimer R, Kosinski J, von Appen A, Beck M, Hurt E. (2017)
A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex.
Nat Commun 8(1):107. doi: 10.1038/s41467-017-01160-9
Europe PMC | doi
Sadian Y, Tafur L, Kosinski J, Jakobi AJ, Wetzel R, Buczak K, Hagen WJ, Beck M, Sachse C, Müller CW. (2017)
Structural insights into transcription initiation by yeast RNA polymerase I.
EMBO J 36(18) doi: 10.15252/embj.201796958
Europe PMC | doi
2016
Dauden MI, Kosinski J, Kolaj-Robin O, Desfosses A, Ori A, Faux C, Hoffmann NA, Onuma OF, Breunig KD, Beck M, Sachse C, Séraphin B, Glatt S, Müller CW. (2016)
Architecture of the yeast Elongator complex
EMBO Rep. 18(2):e201643353. doi: 10.15252/embr.201643353
Europe PMC | doi
Hoffmann NA, Sadian Y, Tafur L, Kosinski J, Müller CW. (2016)
Specialization versus Conservation: How Pol I and Pol III use the conserved architecture of the pre-initiation complex for specialized transcription.
Transcription 7(4):127-132. doi: 10.1080/21541264.2016.1203628
Europe PMC | doi
Bertipaglia C, Schneider S, Jakobi AJ, Tarafder AK, Bykov YS, Picco A, Kukulski W, Kosinski J, Hagen WJ, Ravichandran AC, Wilmanns M, Kaksonen M, Briggs JA, Sachse C. (2016)
Higher-order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle.
EMBO Rep. 17(7):1044-1060. doi: 10.15252/embr.201541960
Europe PMC | doi
Ferber M, Kosinski J, Ori A, Rashid UJ, Moreno-Morcillo M, Simon B, Bouvier G, Batista PR, Müller CW, Beck M, Nilges M. (2016)
Automated structure modeling of large protein assemblies using crosslinks as distance restraints.
Nat. Methods 13(6) doi: 10.1038/nmeth.3838
Europe PMC | doi
Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M. (2016)
Molecular architecture of the inner ring scaffold of the human nuclear pore complex.
Science 352(6283):363-365. doi: 10.1126/science.aaf0643
Europe PMC | doi
Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, Pflug A, Hengrung N, El Omari K, Baudin F, Hart DJ, Beck M, Cusack S. (2016)
Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
Mol. Cell 61(1):125-137. doi: 10.1016/j.molcel.2015.11.016
Europe PMC | doi
2015
Hoffmann NA, Jakobi AJ, Moreno-Morcillo M, Glatt S, Kosinski J, Hagen WJ, Sachse C, Müller CW. (2015)
Molecular structures of unbound and transcribing RNA polymerase III.
Nature 528(7581):231-236. doi: 10.1038/nature16143
Europe PMC | doi
von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M. (2015)
In situ structural analysis of the human nuclear pore complex.
Nature 526(7571):140-143. doi: 10.1038/nature15381
Europe PMC | doi
Kosinski J, von Appen A, Ori A, Karius K, Müller CW, Beck M. (2015)
Xlink Analyzer: Software for analysis and visualization of cross-linking data in the context of three-dimensional structures.
J. Struct. Biol. 189(3):177-183. doi: 10.1016/j.jsb.2015.01.014
Europe PMC | doi
2013
Milanowska K, Krwawicz J, Papaj G, Kosinski J, Poleszak K, Lesiak J, Osinska E, Rother K, Bujnicki JM. (2013)
REPAIRtoire - a database of DNA repair pathways
FEBS J 280:56.
Europe PMC
Kosinski J, Barbato A, Tramontano A. (2013)
MODexplorer: an integrated tool for exploring protein sequence, structure and function relationships
BIOINFORMATICS 29(7):953-954. doi: 10.1093/bioinformatics/btt062
Europe PMC | doi
2012
Barbato A, Benkert P, Schwede T, Tramontano A, Kosinski J. (2012)
Improving your target-template alignment with MODalign
BIOINFORMATICS 28(7):1038-1039. doi: 10.1093/bioinformatics/bts070
Europe PMC | doi
2011
Milanowska K, Krwawicz J, Papaj G, Kosinski J, Poleszak K, Lesiak J, Osinska E, Rother K, Bujnicki JM. (2011)
REPAIRtoire-a database of DNA repair pathways
NUCLEIC ACIDS RES 39:D788-D792. doi: 10.1093/nar/gkq1087
Europe PMC | doi
2010
Kosinski J, Hinrichsen I, Bujnicki JM, Friedhoff P, Plotz G. (2010)
Identification of Lynch Syndrome Mutations in the MLH1-PMS2 Interface That Disturb Dimerization and Mismatch Repair
HUM MUTAT 31(8):975-982. doi: 10.1002/humu.21301
Europe PMC | doi
Pukancsik M, Bekesi A, Klement E, Hunyadi-Gulyas E, Medzihradszky KF, Kosinski J, Bujnicki JM, Alfonso C, Rivas G, Vertessy BG. (2010)
Physiological truncation and domain organization of a novel uracil-DNA-degrading factor
FEBS J 277(5):1245-1259. doi: 10.1111/j.1742-4658.2009.07556.x
Europe PMC | doi
2008
Kosinski J, Plotz G, Guarne A, Bujnicki JM, Friedhoff P. (2008)
The PMS2 subunit of human MutL alpha contains a metal ion binding domain of the iron-dependent repressor protein family
J MOL BIOL 382(3):610-627. doi: 10.1016/j.jmb.2008.06.056
Europe PMC | doi
2007
Kosinski J, Kubareva E, Bujnicki JM. (2007)
A model of restriction endonuclease MvaI in complex with DNA: A template for interpretation of experimental data and a guide for specificity engineering
PROTEINS 68(1):324-336. doi: 10.1002/prot.21460
Europe PMC | doi
Liu Y, Li ZJ, Lin QS, Kosinski J, Seetharaman J, Bujnicki JM, Sivaraman J, Hew CL. (2007)
Structure and Evolutionary Origin of Ca2+-Dependent Herring Type II Antifreeze Protein
PLOS ONE 2(6) doi: 10.1371/journal.pone.0000548
Europe PMC | doi
Chovancova E, Kosinski J, Bujnicki JM, Damborsky J. (2007)
Phylogenetic analysis of haloalkane dehalogenases
PROTEINS 67(2):305-316. doi: 10.1002/prot.21313
Europe PMC | doi
Miyazono K, Watanabe M, Kosinski J, Ishikawa K, Kamo M, Sawasaki T, Nagata K, Bujnicki JM, Endo Y, Tanokura M, Kobayashi I. (2007)
Novel protein fold discovered in the PabI family of restriction enzymes
NUCLEIC ACIDS RES 35(6):1908-1918. doi: 10.1093/nar/gkm091
Europe PMC | doi
2006
Skowronek KJ, Kosinski J, Bujnicki JM. (2006)
Theoretical model of restriction endonuclease HpaI in complex with DNA, predicted by fold recognition and validated by site-directed mutagenesis
PROTEINS 63(4):1059-1068. doi: 10.1002/prot.20920
Europe PMC | doi
Ahrends R, Kosinski J, Kirsch D, Manelyte L, Giron-Monzon L, Hummerich L, Schulz O, Spengler B, Friedhoff P. (2006)
Identifying an interaction site between MutH and the C-terminal domain of MutL by crosslinking, affinity purification, chemical coding and mass spectrometry
NUCLEIC ACIDS RES 34(10):3169-3180. doi: 10.1093/nar/gkl407
Europe PMC | doi
Zegers I, Gigot D, van Vliet F, Tricot C, Aymerich S, Bujnicki JM, Kosinski J, Droogmans L. (2006)
Crystal structure of Bacillus subtilis TrmB, the tRNA (m(7)G46) methyltransferase
NUCLEIC ACIDS RES 34(6):1925-1934. doi: 10.1093/nar/gkl116
Europe PMC | doi
2005
Kosinski J, Steindorf I, Bujnicki JM, Giron-Monzon L, Friedhoff P. (2005)
Analysis of the quaternary structure of the MutL C-terminal domain
J MOL BIOL 351(4):895-909. doi: 10.1016/j.jmb.2005.06.044
Europe PMC | doi
Kosinski J, Feder M, Bujnicki JM. (2005)
The PD-(D/E)XK superfamily revisited: identification of new members among proteins involved in DNA metabolism and functional predictions for domains of (hitherto) unknown function
BMC BIOINFORMATICS 6:172. doi: 10.1186/1471-2105-6-172
Europe PMC | doi
Bujnicki JM, Feder M, Gajda MJ, Kosinski J, Gront D, Kolinski A. (2005)
Protein structure prediction by combination of fold-recognition with de novo folding
FEBS J 272:104.
Kosinski J, Gajda MJ, Cymerman IA, Kurowski MA, Pawlowski M, Boniecki M, Obarska A, Papaj G, Sroczynska-Obuchowicz P, Tkaczuk KL, Sniezynska P, Sasin JM, Augustyn A, Bujnicki JM, Feder M. (2005)
FRankenstein becomes a cyborg: The automatic recombination and realignment of fold recognition models in CASP6
PROTEINS 61:106-113. doi: 10.1002/prot.20726
Europe PMC | doi
2004
Ye XD, O'Neil PK, Foster AN, Gajda MJ, Kosinski J, Kurowski MA, Bujnicki JM, Friedman AM, Bailey-Kellogg C. (2004)
Probabilistic cross-link analysis and experiment planning for high-throughput elucidation of protein structure
PROTEIN SCI 13(12):3298-3313. doi: 10.1110/ps.04846604
Europe PMC | doi