Seminar Colour Guide:              
External Faculty Speaker
Friday, 16 December 2016, 11:00Add to calendarTo be announcedClaire Wyart, Institut du Cerveau et de la Moelle Épinière, , FranceHost: Yannick SchwabSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Wednesday, 11 January 2017, 10:00Add to calendarInvestigating the mechanisms through which condensin associates with chromatin and impinges on gene expression.Pascal Bernard, Ecole Normale Superieure Lyon, FranceHost: Christian HaeringSmall Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Thursday, 12 January 2017, 11:00Add to calendarTo be announcedKay Grünewald, Structural Biology & Oxford Particle Imaging Centre, The Wellcome Trust Centre for Human Genetics, Oxford, United KingdomHost: Manikandan KaruppasamyEMBL Seminar Room, EMBL Grenoble
Seminar given by an external postdoc
Monday, 16 January 2017, 11:00Add to calendarChemokine recognition during immune cell migrationEva Kiermaier, Institute of Science and Technology Austria, AustriaHost: Jan EllenbergSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Friday, 20 January 2017, 11:00Add to calendarDissecting the hypothalamic circuits that regulate appetiteDeniz Atasoy , Istanbul Medical University, TurkeyHost: Cornelius GrossCNR Seminar Room, EMBL Monterotondo
Abstract: Novel tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Activation of starvation-sensitive AGRP neurons can rapidly elicit behavioral state similar to food deprivation, which present an entry point for reverse-engineering neural circuits for hunger. We mapped functional synaptic interactions of AGRP neurons with multiple cell populations in mice and probed the contribution of downstream elements to feeding behaviour using optogenetic and pharmacogenetic techniques. We have also developed tools for detailed structural analysis of AGRP neuronal connections using serial-section electron microscopy. Our results characterized some basic features of functional and anatomical circuit organization for appetite regulating pathways.

External Faculty Speaker
Friday, 20 January 2017, 13:00Add to calendarDissecting bacterial lifestyle with systems-based approachesNassos Typas, EMBL Heidelberg, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
Abstract: We work at the interface of systems biology and molecular mechanism. On one hand we develop and utilize high-throughput quantitative approaches that reveal functional interactions between genes at a whole cell level. On the other hand, we zoom into these networks to understand how different functional modules are interconnected, often at a detailed mechanistic level. Here I will present how we use such approaches to shed light into gene function and pathway organization, to understand the action of drugs and their interplay when combined, and to probe how protein machineries operate at the bacterial cell envelope- how they are organized, how they coordinate their actions and how the cell senses when they are malfunctioning. We have also recently moved our approaches to the host-pathogen interface and the dynamic microbial communities formed in our gut. Our main goals are to: a) elucidate pathways Salmonella uses to hijack its host machinery and b) to probe how gut microbial communities are formed, how they react to nutrition and pharmaceuticals, and how their composition and characteristics affects our health.
Seminar given by an external postdoc
Monday, 23 January 2017, 10:00Add to calendarTo be announcedHector Sanchez Iranzo, Spanish National Centre for Cardiovascular Research, SpainHost: Alba Diz-MunozSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Thursday, 9 February 2017, 14:00Add to calendarTo be announcedManuel Friese, Universitätsklinikum Hamburg-Eppendorf Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Zentrum für Molekulare Neurobiologie Hamburg (ZMNH), GermanyHost: Paul HeppenstallCNR Seminar Room, EMBL Monterotondo
Abstract: Universitätsklinikum Hamburg-Eppendorf Institut für Neuroimmunologie und Multiple Sklerose (INIMS)
Zentrum für Molekulare Neurobiologie Hamburg (ZMNH) Falkenried 94
D-20251 Hamburg
Germany
EMBL - Sapienza Lecture
Friday, 10 February 2017, 11:00Add to calendarTo be announcedPeter Dayan, Gatsby Computational Neuroscience Unit, Sainsbury Wellcome Centre, 25 Howland Street, London W1T 4JG, United KingdomHost: Cornelius Gross / Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma
Abstract: Tags: Neurobiology
Science and Society
Tuesday, 14 February 2017, 15:00Add to calendarWhy time does not heal all wounds: Chronic PainRohini Kuner, Medical Faculty, Heidelberg University, GermanyHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 21 February 2017, 11:00Add to calendarTo be announcedNevan Krogan, University of California, USAHost: Balca Mardin/Benjamin LangThe Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 23 February 2017, 11:00Add to calendarTo be announcedDavid Barford, MRC-LMB (Cambridge, United KingdomHost: Irina CornaciuEMBL Seminar Room, EMBL Grenoble
Science and Society
Thursday, 23 February 2017, 18:00Add to calendarWie Gliazellen zu Nervenzellen werden neue Ansätze zur Therapie nach GehirnverletzungenMagdalena Götz, Ludwig-Maximilians-Universität München, GermanyHost: Halldór StefánssonPrint Media Academy
Abstract: Das menschliche Gehirn kann abgestorbene Nervenzellen größtenteils nicht mehr ersetzen. Um dies zu ändern, untersuchen wir die Mechanismen, wie Nervenzellen während der Entwicklung gebildet werden, um dies dann auch im erwachsenen Gehirn nach Verletzung auslösen zu können. Tatsächlich werden Nervenzellen während der Entwicklung von radialen Gliazellen gebildet, einem Zelltyp der bislang nur als Stützzelle angesehen wurde. Diese Gliazellen gehen bei der Reifung des Säugergehirns verloren und differenzieren in andere Gliazellen aus. Dementsprechend geht auch die Fähigkeit zur Bildung neuer Nervenzellen in den meisten Gehirnregionen verloren, mit Ausnahme weniger Regionen, in welchen radiale Gliazellen erhalten bleiben, und tatsächlich zeitlebens noch neue Nervenzellen gebildet werden. In vielen anderen Wirbeltieren bleiben diese Gliazellen weitverbreitet erhalten (Barbosa et al., Science 2015), und Gehirnverletzungen können ohne Narbenbildung völlig geheilt werden (Baumgart et al., Glia 2010). Wir arbeiten daran zu verstehen, wie diese radialen Gliazellen Nervenzellen bilden, und wie wir die Bildung von Nervenzellen auch in den differenzierten Gliazellen des Säugergehirns wieder auslösen können (als Übersichtsartikel: Masserdotti et al., Development 2016). Diesbezüglich haben wir gerade in den letzten Jahren große Fortschritte gemacht und es gelingt uns nun, viele narbenbildende Gliazellen in reife Nervenzellen nach Gehirnverletzung im Mausmodell umzuwandeln (Gascon et al., Cell Stem Cell 2016). Zudem konnten wir zeigen, dass auch Gehirnregionen, in denen normalerweise keine neue Nervenzellen im Erwachsenenstadium gebildet werden, die Fähigkeit besitzen, neue Nervenzellen wieder passend in das Nervenzellnetzwerk zu integrieren und die Funktion der abgestorbenen Nervenzellen wieder zu ersetzen. Die große Frage ist nun, ob dies auch für lokal aus Gliazellen umgewandelte Nervenzellen möglich ist.
External Faculty Speaker
Friday, 24 February 2017, 11:00Add to calendarTo be announcedBen Lehner , Centre for Genomic Regulation (CRG), Barcelona, Spain, SpainHost: Jamie HackettCNR Seminar Room, EMBL Monterotondo
EMBL - Sapienza Lecture
Friday, 3 March 2017, 11:00Add to calendarEpigenetics and Rett SyndromeAdrian Bird, Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, United KingdomHost: Cornelius Gross / Irene BozzoniSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Friday, 10 March 2017, 10:00Add to calendarTo be announcedEve Marder, Brandeis University, Faculty of Biology, Waltham, MA, USA, USAHost: Philip Avner / Cornelius GrossCNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Tuesday, 21 March 2017, 11:00Add to calendarTo be announcedJürgen Knoblich, Institute of Molecular Biotechnology, AustriaHost: Jan EllenbergThe Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 23 March 2017, 11:00Add to calendarTo be announcedGraziano Martello , Universita delgi Studi di Padova, Dipartimento di Medicina Molecolare, Padova, Italy, ItalyHost: Jamie HackettCNR Seminar Room, EMBL Monterotondo
Abstract:
External Faculty Speaker
Thursday, 30 March 2017, 11:00Add to calendarTo be announcedKay Diederich, University of Konstanz, GermanyHost: Irina CornaciuEMBL Seminar Room, EMBL Grenoble
EMBL - Sapienza Lecture
Friday, 31 March 2017, 11:00Add to calendarTransgenerational epigenetic inheritance: Evidence in mammals and potential mechanisms involving the germlineIsabelle Mansuy, University of Zürich and ETH Zürich, Zurich, SwitzerlandHost: Cornelius Gross / Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
Science and Society
Friday, 31 March 2017, 15:00Add to calendarThe problem with pseudoscienceMichael D. Gordin, Princeton University, USAHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Science and Society
Friday, 7 April 2017, 11:00Add to calendarTo be announcedKristian Andersen, Scripps, STSI Department of Immunology and Microbial Science, La Jolla, California, USAHost: Halldór Stefánsson CNR Seminar Room, EMBL Monterotondo
Science and Society
Friday, 7 April 2017, 14:00Add to calendarTo be announcedBernd Pulverer, EMBO, GermanyHost: Erika Pellegrini ILL Chadwick, EMBL Grenoble
External Faculty Speaker
Thursday, 20 April 2017, 11:00Add to calendarTo be announcedGraziano Martello, Universita delgi Studi di Padova, Dipartimento di Medicina Molecolare, Padova, Italy, ItalyHost: Jamie HackettCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Thursday, 20 April 2017, 11:00Add to calendarTo be announcedFrancesca Mattiroli, Luger Lab, JSCBB, University of Colorado Boulder, 3, USAHost: Valentina SperanziniEMBL Seminar Room, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Monday, 24 April 2017, 11:00Add to calendarNutritional Regulatory Networks Marian Walhout, University of Massachusetts Medical School, USAHost: Anne-Claude GavinThe Operon, EMBL Heidelberg
Abstract: Gene regulation and metabolism lie at the heart of most biological processes. Both are accomplished by complex networks harboring hundreds of nodes and thousands of edges. We study these networks and the interactions between them mainly in the nematode C. elegans, because it is amenable to high-throughput, large-scale genetics and genomics. In addition, we study interspecies network interactions between C. elegans and bacteria, that may help illuminate interactions between mammalian intestinal cells and the gut microbiota.
EMBL Distinguished Visitor Lecture
Tuesday, 25 April 2017, 11:00Add to calendarThree short stories about sex chromosomes Job Dekker, University of Massachusetts Medical School, USAHost: Yad Ghavi HelmThe Operon, EMBL Heidelberg
Abstract: The 3D organization of the genome is critical for gene regulation. I will present three examples where sex chromosomes can serve as powerful models to study the folding of chromosomes in general, to identify cis-elements and proteins involved and to determine how chromosome organization and gene regulation are mechanistically linked.
Science and Society
Tuesday, 25 April 2017, 15:00Add to calendarEthical Review Goes Global: Learning the arts of a good ethical reviewRachel Douglas-Jones, IT University of Copenhagen, DenmarkHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 28 April 2017, 10:00Add to calendarSynaptic Processing of Visual Information in the RetinaLeon Lagnado, School of Life Sciences, , University of Sussex, Brighton, UK, United KingdomHost: Phil AvnerCNR Seminar Room, EMBL Monterotondo
Abstract:
Synapses are perhaps the most numerous computational elements within neural circuits. The process of chemical transmission can transform neural signals and, because synapses are plastic, these transformations can be altered over different time-scales to adjust the input-output relation of the circuit as a whole. I will describe experimental strategies that allow the synaptic basis of neural circuit function to be studied in vivo by imaging of genetically-encoded reporters. I will illustrate how these reporters can be used to analyze the synaptic processing of visual information in the retina of zebrafish. These strategies are revealing how the visual signal is first converted from an analogue format into spikes, as well as the synaptic changes that alter the input-output relation of the retinal circuit. In particular I will describe how plasticity of excitatory and inhibitory synapses can cause simultaneous increases and decreases in the gain of neural responses within distinct microcircuits of the inner retina. The general picture that emerges is one in which plasticity of synapses leads to dynamic changes in the encoding of visual stimuli.
External Faculty Speaker
Thursday, 11 May 2017, 11:00Add to calendarThe regulation of excitability within sensory neurons and pain pathogenesis: from molecule to manDavid Bennett, Nuffield Department of Clinical Neurosciences, University of Oxford, UK, United KingdomHost: Paul HeppenstallCNR Seminar Room, EMBL Monterotondo
Abstract: Neuropathic pain arises as a consequence of excessive excitability within sensory neurons. There has been significant progress over the last decade in understanding the molecular basis by which sensory neurons transduce and subsequently transmit noxious (ie. tissue damaging) stimuli giving rise to the sensation of pain. Over this same period we have recognized that mutations in such ion channels can result in primary pain disorders in humans providing great insight into the genetics of pain. An excellent example is the voltage gated ion channel NaV 1.7. Loss of function mutations in this ion channel result in congenital inability to experience pain and gain of function mutations can cause a number of distinct neuropathic pain disorders including erythromelalgia, paroxysmal extreme pain disorder and small fibre neuropathy. The fact that mutations in such channels can cause monogenic pain disorders makes them attractive analgesic drug targets and we are seeing a number of therapeutics being developed on this basis. Given that spontaneous activity is critical for the induction and maintenance of peripheral neuropathic pain we are now exploring techniques to reversibly silence sensory neurons. We have found that an engineered glutamate gated ion channel (which no longer responds to glutamate but is activated by Ivermectin) is very effective at electrically silencing sensory neurons both in vitro and in vivo. I will discuss how this can be used as a translational tool to reverse pain related hypersensitivity in animal models of neuropathic pain.
EMBL Distinguished Visitor Lecture
Friday, 12 May 2017, 11:00Add to calendarDNMT3A in Hematopoietic Stem Cells, Cancer and AgingMargaret Goodell, Baylor College of Medicine, Houston, Texas, USA, USAHost: Philip Avner / Christophe LancrinCNR Seminar Room, EMBL Monterotondo
Abstract: DNA methyltransferase 3a (DNMT3A) has recently emerged as an important tumor suppressor in hematologic malignancies, and its ablation in mouse hematopoietic stem cells inhibits differentiation. We will describe the use of DNMT3A knockout mice to study its role in myeloid and lymphoid malignancy development and its function in maintaining global DNA methylation. The role of DNMT3A mutations in intercellular competition in the context of aging will also be discussed.
External Faculty Speaker
Monday, 15 May 2017, 11:00Add to calendarTo be announced Katrin Rittinger, The Francis Crick Institute,Molecular Structure of Cell Signalling Laboratory,London, United KingdomHost: Esther OrtegaEMBL Seminar Room, EMBL Grenoble
EMBL - Sapienza Lecture
Friday, 19 May 2017, 11:00Add to calendarStructural dynamics of the breast cancer genome in response to hormonesMiguel Beato, Gene Regulation, Stem Cells and Cancer Program , Centre de Regulació Genòmica (CRG), The Barcelona Institute of Science and Technology, Barcelona , Spain, , SpainHost: Cornelius Gross / Irene BozzoniSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
Abstract: Eukaryotic cells decode environmental information via receptors and signalling networks that converge in the cell nucleus to adjust an integrated gene expression response. We study the response of breast cancer cells to the steroid hormones estrogens and progesterone (Pg) acting via their respective receptors (ER and PR, respectively) to decipher the underlying molecular mechanisms.

The precise organization in nucleosomes of the DNA sequences recognized by PR is a requisite for receptor binding and the initiation of chromatin remodelling leading to displacement of histones H1 and H2A/H2B. Remodelling depends on receptor-associated enzymes, including histone modifying enzymes and ATP-dependent chromatin remodelers, as well as activated PARP1, which uses the NAD+ synthesized by NMNAT1 in the cell nucleus to synthesize large amounts of Poly-ADP-Ribose (PAR). These epigenetic processes are required for chromatin remodelling and the rapid regulation of thousand of genes leading ultimately to cell proliferation in response to hormone.

In addition to nucleosomes, higher levels of genome organization also participate in hormone action. The conserved partition of the genome in consecutive topological associating domains (TADs) contributes to coordination of the hormonal response. Hormone regulated genes tend to segregate into TADs that respond as a whole with either activation or repression of transcription. Genes in one TAD can be all activated by one hormone and all repressed by another hormone. Thus, TADs behave as regulons in the response of cells to external signals. High-resolution Hi-C data reveal the role of dominant enhancers in organizing the differential hormonal response within TADs.

The extensive chromatin remodelling observed in response to hormones requires the transient accumulation in the cell nucleus of large amounts of PAR, which is subsequently degraded to ADPR. A fraction of this ADPR is converted to ATP in the nucleus by NUDIX5 in the presence of PPi. NUDIX5 is a homodimer known to catalyse the hydrolysis of ADPR to AMP and R-5-P, but in response to hormone NUDIX5 is dephosphorylated at T45, leading to a conformational change of the homodimer that enables it to catalyse the reaction of ADPR with PPi to generate ATP and R-5-P. The ATP generated in the cell nucleus is essential for chromatin remodelling and gene regulation by estrogens or progesterone, as well as for DNA damage repair. NUDIX5 is overexpressed in breast cancers and is a marker for poor prognosis. Thus, it represents a novel target for breast cancer management.

EMBL Distinguished Visitor Lecture
Friday, 26 May 2017, 10:00Add to calendarTo be announcedSarah-Jayne Blakemore, Institute of Cognitive Neuroscience, UCL, London, UK, , United KingdomHost: Philip Avner / Cornelius GrossCNR Seminar Room, EMBL Monterotondo
Abstract: Tags: Neurobiology
EMBL Distinguished Visitor Lecture
Monday, 12 June 2017, 11:00Add to calendarTo be announcedWieland Huttner, MPI-CBG, Dresden, GermanyHost: Stefano De RenzisThe Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 27 June 2017, 11:00Add to calendarTo be announcedMaria Carmo-Fonseca , University of Lisbon, PortugalHost: Isabel Chillon EMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Tuesday, 4 July 2017, 11:00Add to calendarTo be announcedEdward Lemke, EMBL Heidelberg, GermanyHost: Francesco BisiakEMBL Seminar Room, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Thursday, 6 July 2017, 11:00Add to calendarTo be announcedOlivier Pourquié, Harvard Medical School, Department of Genetics/The Brigham and Women s Hospital, USAHost: Alexander AulehlaThe Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 14 September 2017, 11:00Add to calendarTo be announcedGene Meyers, MPI-CBG, Dresden, GermanyHost: Stefano De RenzisThe Operon, EMBL Heidelberg
Science and Society
Friday, 29 September 2017, 11:00Add to calendarTo be announcedHelga Nowotny, ETH Zurich, Switzerland, SwitzerlandHost: Halldór Stefánsson CNR Seminar Room, EMBL Monterotondo
Abstract:
EMBL Distinguished Visitor Lecture
Friday, 6 October 2017, 10:00Add to calendarTo be announcedDouglas Higgs, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United KingdomHost: Philip Avner / Christophe LancrinCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 13 October 2017, 11:00Add to calendarTo be announcedAlla Karpova, HHMI Janelia Farm Research Campus, Virginia, USA, USAHost: Cornelius GrossCNR Seminar Room, EMBL Monterotondo
EMBL - Sapienza Lecture
Friday, 3 November 2017, 11:00Add to calendarTo be announcedAnne Ferguson-Smith, Department of Genetics, University of Cambridge, Cambridge , UK, United KingdomHost: Cornelius Gross / Irene BozzoniSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma
Abstract:
EMBL Distinguished Visitor Lecture
Friday, 17 November 2017, 10:00Add to calendarEpigenetic mechanisms in early mammalian developmentMaria Elena Torres-Padilla, Institute of Epigenetics and Stem Cells (IES) , Helmholtz Zentrum München, GermanyHost: Philip Avner CNR Seminar Room, EMBL Monterotondo
Abstract: