EMBL Hamburg, Notkestraße 85, 22607 Hamburg, Germany

Biography

  • PhD 1982, Dr. of Science 1997, Institute of Crystallography, Moscow.
    At EMBL since 1991.
    Group leader since 2003.
    Senior scientist since 2011.

Publications

Total: 512 publication(s)

2020

Sagar A, Svergun D, Bernadó P. (2020)

Structural analyses of intrinsically disordered proteins by small-angle X-ray scattering.

Methods Mol. Biol. 2141:249-269. doi: 10.1007/978-1-0716-0524-0_12
Europe PMC | doi

Sajko S, Grishkovskaya I, Kostan J, Graewert M, Setiawan K, Trübestein L, Niedermüller K, Gehin C, Sponga A, Puchinger M, Gavin AC, Leonard TA, Svergun DI, Smith TK, Morriswood B, Djinovic-Carugo K. (2020)

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats.

PLoS One 15(12) doi: 10.1371/journal.pone.0242677
Europe PMC | doi

Lazar T, Martínez-Pérez E, Quaglia F, Hatos A, Chemes LB, Iserte JA, Méndez NA, Garrone NA, Saldaño TE, Marchetti J, Rueda AJV, Bernadó P, Blackledge M, Cordeiro TN, Fagerberg E, Forman-Kay JD, Fornasari MS, Gibson TJ, Gomes GW, Gradinaru CC, Head-Gordon T, Jensen MR, Lemke EA, Longhi S, Marino-Buslje C, Minervini G, Mittag T, Monzon AM, Pappu RV, Parisi G, Ricard-Blum S, Ruff KM, Salladini E, Skepö M, Svergun D, Vallet SD, Varadi M, Tompa P, Tosatto SCE, Piovesan D. (2020)

PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins.

Nucleic Acids Res doi: 10.1093/nar/gkaa1021
Europe PMC | doi

Custódio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hällberg BM, Löw C. (2020)

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.

Nat Commun 11(1) doi: 10.1038/s41467-020-19204-y
Europe PMC | doi

Graewert MA, Da Vela S, Gräwert TW, Molodenskiy DS, Blanchet CE, Svergun DI, Jeffries CM. (2020)

Adding size exclusion chromatography (SEC) and light scattering (LS) devices to obtain high-quality small angle X-ray scattering (SAXS) data.

Crystals 10(11):975. doi: 10.3390/cryst10110975
doi

Uebbing L, Ziller A, Siewert C, Schroer MA, Blanchet CE, Svergun DI, Ramishetti S, Peer D, Sahin U, Haas H, Langguth P. (2020)

Investigation of pH-responsiveness inside lipid nanoparticles for parenteral mRNA application using small-angle X-ray scattering.

Langmuir doi: 10.1021/acs.langmuir.0c02446
Europe PMC | doi

Büttner H, Perbandt M, Kohler T, Kikhney A, Wolters M, Christner M, Heise M, Wilde J, Weißelberg S, Both A, Betzel C, Hammerschmidt S, Svergun D, Aepfelbacher M, Rohde H. (2020)

A giant extracellular matrix binding protein of staphylococcus epidermidis binds surface-immobilized fibronectin via a novel mechanism.

mBio 11(5) doi: 10.1128/mBio.01612-20
Europe PMC | doi

Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Löw C. (2020)

Structural role of essential light chains in the apicomplexan glideosome.

Commun Biol 3(1) doi: 10.1038/s42003-020-01283-8
Europe PMC | doi

Sicorello A, Różycki B, Konarev PV, Svergun DI, Pastore A. (2020)

Capturing the conformational ensemble of the mixed folded polyglutamine Protein Ataxin-3.

Structure doi: 10.1016/j.str.2020.09.010
Europe PMC | doi

Kukkurainen S, Azizi L, Zhang P, Jacquier MC, Baikoghli M, von Essen M, Tuukkanen A, Laitaoja M, Liu X, Rahikainen R, Orłowski A, Jänis J, Määttä JAE, Varjosalo M, Vattulainen I, Róg T, Svergun D, Cheng RH, Wu J, Hytönen VP, Wehrle-Haller B. (2020)

The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering.

J Cell Sci 133(19) doi: 10.1242/jcs.239202
Europe PMC | doi

Siewert CD, Haas H, Cornet V, Nogueira SS, Nawroth T, Uebbing L, Ziller A, Al-Gousous J, Radulescu A, Schroer MA, Blanchet CE, Svergun DI, Radsak MP, Sahin U, Langguth P. (2020)

Hybrid biopolymer and lipid nanoparticles with improved transfection efficacy for mRNA.

Cells 9(9) doi: 10.3390/cells9092034
Europe PMC | doi

Lahey-Rudolph JM, Schönherr R, Jeffries CM, Blanchet CE, Boger J, Ferreira Ramos AS, Riekehr WM, Triandafillidis DP, Valmas A, Margiolaki I, Svergun D, Redecke L. (2020)

Rapid screening of in cellulo grown protein crystals via a small-angle X-ray scattering/X-ray powder diffraction synergistic approach.

J Appl Crystallogr 53(Pt 5):1169-1180. doi: 10.1107/S1600576720010687
Europe PMC | doi

Osz J, McEwen AG, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries CM, Svergun DI, Rochel N. (2020)

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR.

Nucleic Acids Res 48(17):9969-9985. doi: 10.1093/nar/gkaa697
Europe PMC | doi

Knittel V, Sadana P, Seekircher S, Stolle AS, Körner B, Volk M, Jeffries CM, Svergun DI, Heroven AK, Scrima A, Dersch P. (2020)

RovC - a novel type of hexameric transcriptional activator promoting type VI secretion gene expression.

PLoS Pathog 16(9) doi: 10.1371/journal.ppat.1008552
Europe PMC | doi

Schewa S, Schroer MA, Zickmantel T, Song YH, Blanchet CE, Gruzinov AY, Katona G, Svergun DI, Roessle M. (2020)

A THz transparent 3D printed microfluidic cell for small angle x-ray scattering.

Rev Sci Instrum 91(8) doi: 10.1063/5.0004706
Europe PMC | doi

Mestrom L, Marsden SR, van der Eijk H, Laustsen JU, Jeffries CM, Svergun DI, Hagedoorn PL, Bento I, Hanefeld U. (2020)

Anomeric selectivity of trehalose transferase with rare L-sugars.

ACS Catal. 10(15):8835-8839. doi: 10.1021/acscatal.0c02117
Europe PMC | doi

Solomon-Degefa H, Gebauer JM, Jeffries CM, Freiburg CD, Meckelburg P, Bird LE, Baumann U, Svergun DI, Owens RJ, Werner JM, Behrmann E, Paulsson M, Wagener R. (2020)

Structure of a collagen VI α3 chain VWA domain array: adaptability and functional implications of myopathy causing mutations.

J. Biol. Chem. 295(36) doi: 10.1074/jbc.RA120.014865
Europe PMC | doi

Jeffries CM, Pietras Z, Svergun DI. (2020)

The basics of small-angle neutron scattering (SANS for new users of structural biology).

In: Combet S and Schirò G, Neutrons and Biology. EPJ Web of Conferences. EDP Sciences.EPJ Web Conf doi: 10.1051/epjconf/202023603001
doi

Burda PC, Crosskey T, Lauk K, Zurborg A, Söhnchen C, Liffner B, Wilcke L, Pietsch E, Strauss J, Jeffries CM, Svergun DI, Wilson DW, Wilmanns M, Gilberger TW. (2020)

Structure-based identification and functional characterization of a lipocalin in the malaria parasite Plasmodium falciparum.

Cell Rep 31(12) doi: 10.1016/j.celrep.2020.107817
Europe PMC | doi

Molodenskiy DS, Mertens HDT, Svergun DI. (2020)

An automated data processing and analysis pipeline for transmembrane proteins in detergent solutions.

Sci Rep 10(1) doi: 10.1038/s41598-020-64933-1
Europe PMC | doi

Butt BG, Owen DJ, Jeffries CM, Ivanova L, Hill CH, Houghton JW, Ahmed MF, Antrobus R, Svergun DI, Welch JJ, Crump CM, Graham SC. (2020)

Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex.

Elife 9 doi: 10.7554/eLife.53789
Europe PMC | doi

Duarte DP, Lamontanara AJ, La Sala G, Jeong S, Sohn YK, Panjkovich A, Georgeon S, Kükenshöner T, Marcaida MJ, Pojer F, De Vivo M, Svergun D, Kim HS, Dal Peraro M, Hantschel O. (2020)

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.

Nat Commun 11(1) doi: 10.1038/s41467-020-16128-5
Europe PMC | doi

Dadinova LA, Soshinskaia EY, Jeffries CM, Svergun DI, Shtykova EV. (2020)

Tetrameric Structures of Inorganic CBS-Pyrophosphatases from Various Bacterial Species Revealed by Small-Angle X-ray Scattering in Solution.

Biomolecules 10(4) doi: 10.3390/biom10040564
Europe PMC | doi

Franke D, Hajizadeh NR, Svergun DI. (2020)

Simulation of small-angle X-ray scattering data of biological macromolecules in solution.

J Appl Crystallogr 53(Pt 2):536-539. doi: 10.1107/S1600576720000527
Europe PMC | doi

Czech A, Konarev PV, Goebel I, Svergun DI, Wills PR, Ignatova Z. (2020)

Author correction: Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes.

Sci Rep 10(1) doi: 10.1038/s41598-020-61336-0
Europe PMC | doi

Petukhov MV, Konarev PV, Dadinova LA, Fedorova NV, Volynsky PE, Svergun DI, Batishchev OV, Shtykova EV. (2020)

Quasi-atomistic approach to modeling of liposomes.

Crystallogr. Rep. 65(2):258-263. doi: 10.1134/S1063774520020182
doi

Gräwert TW, Svergun DI. (2020)

Structural modeling using solution small-angle X-ray scattering (SAXS).

J. Mol. Biol. 432(9):3078-3092. doi: 10.1016/j.jmb.2020.01.030
Europe PMC | doi

Konarev PV, Petoukhov MV, Dadinova LA, Fedorova NV, Volynsky PE, Svergun DI, Batishchev OV, Shtykova EV. (2020)

BILMIX: a new approach to restore the size polydispersity and electron density profiles of lipid bilayers from liposomes using small-angle X-ray scattering data.

J Appl Crystallogr 53:236-243. doi: 10.1107/S1600576719015656
doi

Janisova L, Gruzinov A, Zaborova OV, Velychkivska N, Vaněk O, Chytil P, Etrych T, Janoušková O, Zhang X, Blanchet C, Papadakis CM, Svergun DI, Filippov SK. (2020)

Molecular mechanisms of the interactions of N-(2-hydroxypropyl)methacrylamide copolymers designed for cancer therapy with blood plasma proteins.

Pharmaceutics 12(2) doi: 10.3390/pharmaceutics12020106
Europe PMC | doi

Trstenjak N, Milić D, Graewert MA, Rouha H, Svergun D, Djinović-Carugo K, Nagy E, Badarau A. (2020)

Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity.

Proc. Natl. Acad. Sci. U.S.A. 117(1):317-327. doi: 10.1073/pnas.1913690116
Europe PMC | doi

Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI. (2020)

SASBDB: towards automatically curated and validated repository for biological scattering data.

Protein Sci. 29(1):66-75. doi: 10.1002/pro.3731
Europe PMC | doi


2019

Josts I, Gao Y, Monteiro DCF, Niebling S, Nitsche J, Veith K, Gräwert TW, Blanchet CE, Schroer MA, Huse N, Pearson AR, Svergun DI, Tidow H. (2019)

Structural kinetics of MsbA investigated by stopped-flow time-resolved small-angle X-ray scattering.

Structure 28(3) doi: 10.1016/j.str.2019.12.001
Europe PMC | doi

Nasta V, Da Vela S, Gourdoupis S, Ciofi-Baffoni S, Svergun DI, Banci L. (2019)

Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery.

Sci Rep 9(1) doi: 10.1038/s41598-019-55313-5
Europe PMC | doi

Majorošová J, Schroer MA, Tomašovičová N, Batková M, Hu PS, Kubovčíková M, Svergun DI, Kopčanský P. (2019)

Effect of the concentration of protein and nanoparticles on the structure of biohybrid nanocomposites.

Biopolymers 111(2) doi: 10.1002/bip.23342
Europe PMC | doi

Berman HM, Adams PD, Bonvin AA, Burley SK, Carragher B, Chiu W, DiMaio F, Ferrin TE, Gabanyi MJ, Goddard TD, Griffin PR, Haas J, Hanke CA, Hoch JC, Hummer G, Lawson CL, Kurisu G, Markley JL, Leitner A, Montelione GT, Meiler J, Prisner T, Phillips GN, Schriemer DC, Rappsilber J, Seidel CAM, Schwede T, Svergun DI, Strutzenberg TS, Trewhella J, Tajkhorshid E, Vuister GW, Webb B, Vallat B, Velankar S, Sali A, Westbrook JD, White KL. (2019)

Federating structural models and data: outcomes from a workshop on archiving integrative structures.

Structure 27(12):1745-1759. doi: 10.1016/j.str.2019.11.002
Europe PMC | doi

Shtykova EV, Petoukhov MV, Mozhaev AA, Deyev IE, Dadinova LA, Loshkarev NA, Goryashchenko AS, Bocharov EV, Jeffries CM, Svergun DI, Batishchev OV, Petrenko AG. (2019)

The dimeric ectodomain of the alkali-sensing insulin receptor-related receptor (ectoIRR) has a drop-like shape.

J. Biol. Chem. 294(47):17790-17798. doi: 10.1074/jbc.RA119.010390
Europe PMC | doi

Polykretis P, Luchinat E, Bonucci A, Giachetti A, Graewert MA, Svergun DI, Banci L. (2019)

Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach.

IUCrJ 6(Pt 5):948-957. doi: 10.1107/S205225251901073X
Europe PMC | doi

Manalastas-Cantos K, M, Haering CH, Svergun DI. (2019)

Solution structure and flexibility of the condensin HEAT-repeat subunit Ycg1.

J. Biol. Chem. 294(37):13822-13829. doi: 10.1074/jbc.RA119.008661
Europe PMC | doi

Nagel N, Graewert MA, Gao M, Heyse W, Jeffries CM, Svergun D, Berchtold, H.. (2019)

The quaternary structure of insulin glargine and glulisine under formulation conditions.

Biophys. Chem. 253 doi: 10.1016/j.bpc.2019.106226
Europe PMC | doi

Bernal I, Börnicke J, Heidemann J, Svergun D, Horstmann JA, Erhardt M, Tuukkanen A, Uetrecht C, Kolbe M. (2019)

Molecular organization of soluble type III secretion system sorting platform complexes.

J. Mol. Biol. 431(19):3787-3803. doi: 10.1016/j.jmb.2019.07.004
Europe PMC | doi

Peter MF, Tuukkanen AT, Heubach CA, Selsam A, Duthie FG, Svergun DI, Schiemann O, Hagelueken G. (2019)

Studying conformational changes of the Yersinia type-III-secretion effector YopO in solution by integrative structural biology.

Structure 27(9):1416-1426.e3. doi: 10.1016/j.str.2019.06.007
Europe PMC | doi

Verschueren KHG, Blanchet C, Felix J, Dansercoer A, De Vos D, Bloch Y, Van Beeumen J, Svergun D, Gutsche I, Savvides SN, Verstraete K. (2019)

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.

Nature 568(7753):571-575. doi: 10.1038/s41586-019-1095-5
Europe PMC | doi

Kukic P, Lo Piccolo GM, Nogueira MO, Svergun DI, Vendruscolo M, Felli IC, Pierattelli R. (2019)

The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.

Sci Rep 9(1) doi: 10.1038/s41598-019-41925-4
Europe PMC | doi

Czech A, Konarev PV, Goebel I, Svergun DI, Wills PR, Ignatova Z. (2019)

Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes.

Sci Rep 9(1) doi: 10.1038/s41598-019-39213-2
Europe PMC | doi

Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Schnappinger D, Svergun DI, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O. (2019)

An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death.

Mol Cell 73(6):1282-1291. doi: 10.1016/j.molcel.2019.01.028
Europe PMC | doi

Ramos J, Muthukumaran J, Freire F, Paquete-Ferreira J, Otrelo-Cardoso AR, Svergun D, Panjkovich A, Santos-Silva T. (2019)

Shedding light on the interaction of human anti-apoptotic Bcl-2 protein with ligands through biophysical and in silico studies.

Int J Mol Sci 20(4) doi: 10.3390/ijms20040860
Europe PMC | doi

Manalastas KG, Svergun DI. (2019)

Molecular dissection of the intrinsically disordered estrogen receptor Alpha-NTD.

Structure 27(2):207-208. doi: 10.1016/j.str.2019.01.006
Europe PMC | doi

Siewert C, Haas H, Nawroth T, Ziller A, Nogueira SS, Schroer MA, Blanchet CE, Svergun DI, Radulescu A, Bates F, Huesemann Y, Radsak MP, Sahin U, Langguth P. (2019)

Investigation of charge ratio variation in mRNA - DEAE-dextran polyplex delivery systems.

Biomaterials 192:612-620. doi: 10.1016/j.biomaterials.2018.10.020
Europe PMC | doi

Yang Y, Back CR, Gräwert MA, Wahid AA, Denton H, Kildani R, Paulin J, Wörner K, Kaiser W, Svergun DI, Sartbaeva A, Watts AG, Marchbank KJ, van den Elsen JMH. (2019)

Utilization of staphylococcal immune evasion protein Sbi as a novel vaccine adjuvant.

Front Immunol 9 doi: 10.3389/fimmu.2018.03139
Europe PMC | doi

Esposito A, Ventura V, Petoukhov MV, Rai A, Svergun DI, Vanoni MA. (2019)

Human MICAL1: activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.

Protein Sci 28(1) doi: 10.1002/pro.3512
Europe PMC | doi


2018

Shtykova EV, Petoukhov MV, Dadinova LA, Fedorova NV, Tashkin VY, Timofeeva TA, Ksenofontov AL, Loshkarev NA, Baratova LA, Jeffries CM, Svergun DI, Batishchev OV. (2018)

Solution structure, self-assembly and membrane interactions of the matrix protein from Newcastle disease virus at neutral and acidic pH.

J. Virol. 93(6) doi: 10.1128/JVI.01450-18
Europe PMC | doi

Nitsche J, Josts I, Heidemann J, Mertens HD, Maric S, Moulin M, Haertlein M, Busch S, Forsyth VT, Svergun DI, Uetrecht C, Tidow H. (2018)

Structural basis for activation of plasma-membrane Ca2+-ATPase by calmodulin.

Commun Biol 1 doi: 10.1038/s42003-018-0203-7
Europe PMC | doi

Hajizadeh N, Pieprzyk J, Skopintsev P, Flayhan A, Svergun DI, Loew C. (2018)

Probing the architecture of a multi-PDZ domain protein: structure of PDZK1 in solution.

Structure 26(11):1522-1533. doi: 10.1016/j.str.2018.07.016
Europe PMC | doi

Blaschke U, Suwono B, Zafari S, Ebersberger I, Skiebe E, Jeffries CM, Svergun DI, Wilharm G. (2018)

Recombinant production of A1S_0222 from acinetobacter baumannii ATCC 17978 and confirmation of its DNA-(adenine N6)-methyltransferase activity.

Protein Expr. Purif. 151:78-85. doi: 10.1016/j.pep.2018.06.009
Europe PMC | doi

Gupta AA, Reinartz I, Karunanithy G, Spilotros A, Jonna VR, Hofer A, Svergun DI, Baldwin AJ, Schug A, Wolf-Watz M. (2018)

Formation of a Secretion-Competent Protein Complex by a Dynamic Wrap-around Binding Mechanism.

J. Mol. Biol. 430(18 Pt B):3157-3169. doi: 10.1016/j.jmb.2018.07.014
Europe PMC | doi

Fuertes G, Banterle N, Ruff KM, Chowdhury A, Pappu RV, Svergun DI, Lemke EA. (2018)

Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water".

Science 361(6405) doi: 10.1126/science.aau8230
Europe PMC | doi

Josts I, Nitsche J, Maric S, Mertens HD, Moulin M, Haertlein M, Prevost S, Svergun DI, Busch S, Forsyth VT, Tidow H. (2018)

Conformational states of ABC transporter MsbA in a lipid environment investigated by small-angle scattering using stealth carrier nanodiscs.

Structure 26(8):1072-1079.e4. doi: 10.1016/j.str.2018.05.007
Europe PMC | doi

Martínez-Lumbreras S, Krysztofinska EM, Thapaliya A, Spilotros A, Matak-Vinkovic D, Salvadori E, Roboti P, Nyathi Y, Muench JH, Roessler MM, Svergun DI, High S, Isaacson RL. (2018)

Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.

BMC Biol. 16(1) doi: 10.1186/s12915-018-0542-3
Europe PMC | doi

Petoukhov MV, Sokolov AV, Dadinova LA, Gorbunov NP, Svergun DI, Samygina VR. (2018)

Small-Angle X-ray Scattering Study of Macrophage Migration Inhibitory Factor Complexed with Albumin

CRYSTALLOGR REP+ 63(4):589-593. doi: 10.1134/S106377451804020X
doi

Schroer MA, Blanchet CE, Gruzinov AY, Gräwert MA, Brennich ME, Hajizadeh NR, Jeffries CM, Svergun DI. (2018)

Smaller capillaries improve the small-angle X-ray scattering signal and sample consumption for biomacromolecular solutions.

J Synchrotron Radiat 25:1113-1122. doi: 10.1107/S1600577518007907
Europe PMC | doi

iNEXT Consortium. (2018)

iNEXT: a European facility network to stimulate translational structural biology.

FEBS Lett. 592(12) doi: 10.1002/1873-3468.13062
Europe PMC | doi

Franke D, Jeffries CM, Svergun DI. (2018)

Machine Learning Methods for X-Ray Scattering Data Analysis from Biomacromolecular Solutions.

Biophys. J. 114(11):2485-2492. doi: 10.1016/j.bpj.2018.04.018
Europe PMC | doi

Panjkovich A, Svergun DI. (2018)

CHROMIXS: automatic and interactive analysis of chromatography-coupled small angle X-ray scattering data.

Bioinformatics 34(11) doi: 10.1093/bioinformatics/btx846
Europe PMC | doi

Konarev PV, Svergun DI. (2018)

Direct shape determination of intermediates in evolving macromolecular solutions from small-angle scattering data.

IUCrJ 5(Pt 4):402-409. doi: 10.1107/S2052252518005900
Europe PMC | doi

Cordeiro M, Otrelo-Cardoso AR, Svergun DI, Konarev PV, Lima JC, Santos-Silva T, Baptista PV. (2018)

Optical and Structural Characterization of a Chronic Myeloid Leukemia DNA Biosensor.

ACS Chem Biol 13(5) doi: 10.1021/acschembio.8b00029
Europe PMC | doi

Marcianò G, Da Vela S, Tria G, Svergun DI, Byron O, Huang DT. (2018)

Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones.

J Biol Chem 293(26) doi: 10.1074/jbc.RA117.000994
Europe PMC | doi

Hajizadeh NR, Franke D, Jeffries CM, Svergun DI.. (2018)

Consensus bayesian assessment of protein molecular mass from solution X-ray scattering data.

Sci Rep 8(1):7204. doi: 10.1038/s41598-018-25355-2
Europe PMC | doi

Hajizadeh NR, Franke D, Svergun DI. (2018)

Integrated beamline control and data acquisition for small-angle X-ray scattering at the P12 BioSAXS beamline at PETRAIII storage ring DESY.

J Synchrotron Radiat 25(Pt 3):906-914. doi: 10.1107/S1600577518005398
Europe PMC | doi

Slonimskiy YB, Maksimov EG, Lukashev EP, Moldenhauer M, Jeffries CM, Svergun DI, Friedrich T, Sluchanko NN.. (2018)

Functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP

Biochimica et biophysica acta - Bioenergetics 1859(5):382-393. doi: 10.1016/j.bbabio.2018.03.001
Europe PMC | doi

Chen PC, Masiewicz P, Rybin V, Svergun D, Hennig J. (2018)

A general small-angle X-ray scattering-based screening protocol validated for protein-RNA interactions.

ACS Comb Sci 20(4) doi: 10.1021/acscombsci.8b00007
Europe PMC | doi

Luo Z, Marson D, Ong QK, Loiudice A, Kohlbrecher J, Radulescu A, Krause-Heuer A, Darwish T, Balog S, Buonsanti R, Svergun DI, Posocco P, Stellacci F. (2018)

Quantitative 3D determination of self-assembled structures on nanoparticles using small angle neutron scattering.

Nat Commun 9(1) doi: 10.1038/s41467-018-03699-7
Europe PMC | doi

Schroer MA, Svergun DI. (2018)

Recent developments in small-angle X-ray scattering and hybrid method approaches for biomacromolecular solutions

Emerging Topics in Life Sciences 2(1):69-79. doi: 10.1042/ETLS20170138
doi

Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang JH, Meijers R. (2018)

Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC.

Neuron 97(6) doi: 10.1016/j.neuron.2018.02.010
Europe PMC | doi

de Moura TR, Mozaffari-Jovin S, Szabó CZK, Schmitzová J, Dybkov O, Cretu C, Kachala M, Svergun D, Urlaub H, Lührmann R, Pena V. (2018)

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.

Mol Cell 69(6):979-992.e6. doi: 10.1016/j.molcel.2018.02.022
Europe PMC | doi

Nyíri K, Mertens HDT, Tihanyi B, Nagy GN, Kőhegyi B, Matejka J, Harris MJ, Szabó JE, Papp-Kádár V, Németh-Pongrácz V, Ozohanics O, Vékey K, Svergun DI, Borysik AJ, Vértessy BG. (2018)

Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.

Sci Rep 8(1):4326. doi: 10.1038/s41598-018-22145-8
Europe PMC | doi

Bunney TD, Inglis AJ, Sanfelice D, Farrell B, Kerr CJ, Thompson GS, Masson GR, Thiyagarajan N, Svergun DI, Williams RL, Breeze AL, Katan M. (2018)

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.

Structure 26(3) doi: 10.1016/j.str.2018.01.016
Europe PMC | doi

Falke S, Dierks K, Blanchet C, Graewert M, Cipriani F, Meijers R, Svergun D, Betzel C. (2018)

Multi-channel in situ dynamic light scattering instrumentation enhancing biological small-angle X-ray scattering experiments at the PETRA III beamline P12.

J Synchrotron Radiat 25(Pt 2):361-372. doi: 10.1107/S1600577517017568
Europe PMC | doi

Kordyukova LV, Shtykova EV, Baratova LA, Svergun DI, Batishchev OV. (2018)

Matrix proteins of enveloped viruses: a case study of Influenza A virus M1 protein.

J. Biomol. Struct. Dyn. 37(3):671-690. doi: 10.1080/07391102.2018.1436089
Europe PMC | doi

Zhang X, Niebuur BJ, Chytil P, Etrych T, Filippov SK, Kikhney A, Wieland DCF, Svergun DI, Papadakis CM. (2018)

Macromolecular pHPMA-Based Nanoparticles with Cholesterol for Solid Tumor Targeting: Behavior in HSA Protein Environment.

Biomacromolecules 19(2) doi: 10.1021/acs.biomac.7b01579
Europe PMC | doi

Flayhan A, Mertens HDT, Ural-Blimke Y, Martinez Molledo M, Svergun DI, Löw C. (2018)

Saposin Lipid Nanoparticles: A Highly Versatile and Modular Tool for Membrane Protein Research.

Structure 26(2):345-355.e5. doi: 10.1016/j.str.2018.01.007
Europe PMC | doi

Adinolfi S, Puglisi R, Crack JC, Iannuzzi C, Dal Piaz F, Konarev PV, Svergun DI, Martin S, Le Brun NE, Pastore A. (2018)

The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX.

Front Mol Biosci 4:97. doi: 10.3389/fmolb.2017.00097
Europe PMC | doi

Aronsson A, Güler F, Petoukhov MV, Crennell SJ, Svergun DI, Linares-Pastén JA, Karlsson EN. (2018)

Structural insights of RmXyn10A - A prebiotic-producing GH10 xylanase with a non-conserved aglycone binding region.

Biochim. Biophys. Acta 1866(2) doi: 10.1016/j.bbapap.2017.11.006
Europe PMC | doi

Garcia-Alai MM, Heidemann J, Skruzny M, Gieras A, Mertens HDT, Svergun DI, Kaksonen M, Uetrecht C, Meijers R. (2018)

Epsin and Sla2 form assemblies through phospholipid interfaces.

Nat Commun 9(1) doi: 10.1038/s41467-017-02443-x
Europe PMC | doi

Pflüger T, Hernández CF, Lewe P, Frank F, Mertens H, Svergun D, Baumstark MW, Lunin VY, Jetten MSM, Andrade SLA. (2018)

Signaling ammonium across membranes through an ammonium sensor histidine kinase.

Nat Commun 9(1) doi: 10.1038/s41467-017-02637-3
Europe PMC | doi


2017

Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Löhr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Güntert P, Dötsch V, Koide S, Gavin AC, Hantschel O. (2017)

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.

Nat Commun 8(1) doi: 10.1038/s41467-017-02313-6
Europe PMC | doi

Shtykova EV, Dadinova LA, Fedorova NV, Golanikov AE, Bogacheva EN, Ksenofontov AL, Baratova LA, Shilova LA, Tashkin VY, Galimzyanov TR, Jeffries CM, Svergun DI, Batishchev OV. (2017)

Influenza virus Matrix Protein M1 preserves its conformation with pH, changing multimerization state at the priming stage due to electrostatics.

Sci Rep 7(1) doi: 10.1038/s41598-017-16986-y
Europe PMC | doi

Gdovinová V, Schroer MA, Tomašovičová N, Appel I, Behrens S, Majorošová J, Kováč J, Svergun DI, Kopčanský P. (2017)

Structuralization of magnetic nanoparticles in 5CB liquid crystals.

Soft Matter 13(43) doi: 10.1039/c7sm01234a
Europe PMC | doi

Trewhella J, Duff AP, Durand D, Gabel F, Guss JM, Hendrickson WA, Hura GL, Jacques DA, Kirby NM, Kwan AH, Pérez J, Pollack L, Ryan TM, Sali A, Schneidman-Duhovny D, Schwede T, Svergun DI, Sugiyama M, Tainer JA, Vachette P, Westbrook J, Whitten AE. (2017)

2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update.

Acta Crystallogr D Struct Biol 73(Pt 9):710-728. doi: 10.1107/S2059798317011597
Europe PMC | doi

Filippov SK, Verbraeken B, Konarev PV, Svergun DI, Angelov B, Vishnevetskaya NS, Papadakis CM, Rogers S, Radulescu A, Courtin T, Martins JC, Starovoytova L, Hruby M, Stepanek P, Kravchenko VS, Potemkin II, Hoogenboom R. (2017)

Block and Gradient Copoly(2-oxazoline) Micelles: Strikingly Different on the Inside.

J Phys Chem Lett 8(16):3800-3804. doi: 10.1021/acs.jpclett.7b01588
Europe PMC | doi

Mertens HDT, Svergun DI. (2017)

Combining NMR and small angle X-ray scattering for the study of biomolecular structure and dynamics.

Arch Biochem Biophys 628 doi: 10.1016/j.abb.2017.05.005
Europe PMC | doi

Tuukkanen AT, Spilotros A, Svergun DI. (2017)

Progress in small-angle scattering from biological solutions at high-brilliance synchrotrons.

IUCrJ 4(Pt 5):518-528. doi: 10.1107/S2052252517008740
Europe PMC | doi

Fuertes G, Banterle N, Ruff KM, Chowdhury A, Mercadante D, Koehler C, Kachala M, Estrada Girona G, Milles S, Mishra A, Onck PR, Gräter F, Esteban-Martín S, Pappu RV, Svergun DI, Lemke EA. (2017)

Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements.

Proc Natl Acad Sci U S A 114(31):E6342-E6351. doi: 10.1073/pnas.1704692114
Europe PMC | doi

Otrelo-Cardoso AR, Nair RR, Correia MAS, Cordeiro RSC, Panjkovich A, Svergun DI, Santos-Silva T, Rivas MG. (2017)

Highly selective tungstate transporter protein TupA from Desulfovibrio alaskensis G20.

Sci Rep 7(1) doi: 10.1038/s41598-017-06133-y
Europe PMC | doi

Holdbrook DA, Burmann BM, Huber RG, Petoukhov MV, Svergun DI, Hiller S, Bond PJ. (2017)

A Spring-Loaded Mechanism Governs the Clamp-like Dynamics of the Skp Chaperone.

Structure 25(7):1079-1088.e3. doi: 10.1016/j.str.2017.05.018
Europe PMC | doi

Franke D, Petoukhov MV, Konarev PV, Panjkovich A, Tuukkanen A, Mertens HDT, Kikhney AG, Hajizadeh NR, Franklin JM, Jeffries CM, Svergun DI. (2017)

ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions

J Appl Crystallogr 50(4):1212-1225. doi: 10.1107/S1600576717007786
Europe PMC | doi

Beckham KS, Ciccarelli L, Bunduc CM, Mertens HD, Ummels R, Lugmayr W, Mayr J, Rettel M, Savitski MM, Svergun DI, Bitter W, Wilmanns M, Marlovits TC, Parret AH, Houben EN. (2017)

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

Nat Microbiol 2(6):17047. doi: 10.1038/nmicrobiol.2017.47
Europe PMC | doi

Sundaramoorthy R, Hughes AL, Singh V, Wiechens N, Ryan DP, El-Mkami H, Petoukhov M, Svergun DI, Treutlein B, Quack S, Fischer M, Michaelis J, Böttcher B, Norman DG, Owen-Hughes T. (2017)

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.

Elife 6:1-28. doi: 10.7554/elife.22510
Europe PMC | doi

Sviridova E, Rezacova P, Bondar A, Veverka V, Novak P, Schenk G, Svergun DI, Kuta Smatanova I, Bumba L. (2017)

Structural basis of the interaction between the putative adhesion-involved and iron-regulated FrpD and FrpC proteins of Neisseria meningitidis.

Sci Rep 7(40408):1-14. doi: 10.1038/srep40408
Europe PMC | doi

Mauricio RP, Jeffries CM, Svergun DI, Deane JE. (2017)

The Shigella Virulence Factor IcsA Relieves N-WASP Autoinhibition by Displacing the Verprolin Homology/Cofilin/Acidic (VCA) Domain.

J. Biol. Chem. 292(1):134-145. doi: 10.1074/jbc.m116.758003
Europe PMC | doi

Kikhney A, Jeffries CM, Borges CR, Hajizadeh N, Manalastas KK, Svergun DI. (2017)

Validation of biological small-angle scattering data and models in SASBDB.

In: Acta Cryst. , Abstracts of the XXIV IUCr Congress.Acta Crystallogr., A, Found. Crystallogr. doi: https://doi.org/10.1107/s2053273317081360
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