Top image

Staff at EMBL

CP-60003233

Dr. Dmitri Svergun

Group Leader and Senior Scientist
Svergun Group

EMBL Hamburg c/o DESY, Notkestraße 85, 22603 Hamburg, Germany

E-mail: send a mail

Biography

PhD 1982, Dr. of Science 1997, Institute of Crystallography, Moscow.
At EMBL since 1991.
Group leader since 2003.
Senior scientist since 2011.

Publications

Total: 339 publication(s)

2014

Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HD, Svergun DI, Zhang Y, Wang JH, Meijers R. (2014)
The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue
Neuron doi:10.1016/j.neuron.2014.07.010
Europe PMC | doi

Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N. (2014)
A conformational switch in collybistin determines the differentiation of inhibitory postsynapses
EMBO J. doi:10.15252/embj.201488143
Europe PMC | doi

Dunne M, Mertens HD, Garefalaki V, Jeffries CM, Thompson A, Lemke EA, Svergun DI, Mayer MJ, Narbad A, Meijers R. (2014)
The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor
PLoS Pathog. 10(7):e1004228. doi:10.1371/journal.ppat.1004228
Europe PMC | doi

Morgan DG, Boris BS, Kuchkina NV, Yuzik-Klimova EY, Sorokina SA, Stein BD, Svergun DI, Spilotros A, Kostopoulou A, Lappas A, Shifrina ZB, Bronstein LM. (2014)
Multicore Iron Oxide Mesocrystals Stabilized by a Poly(phenylenepyridyl) Dendron and Dendrimer: Role of the Dendron/Dendrimer Self-Assembly
LANGMUIR 30(28):8543-8550. doi:10.1021/la502409r
Europe PMC | doi

Morgan DG, Boris BS, Kuchkina NV, Yuzik-Klimova EY, Sorokina S, Stein BD, Svergun DI, Spilotros A, Kostopoulou A, Lappas A, Shifrina ZB, Bronstein LM. (2014)
Multicore Iron Oxide Mesocrystals Stabilized by Polyphe-nylenepyridyl Dendron and Dendrimer: Role of the Den-dron/Dendrimer Self-assembly
Langmuir doi:10.1021/la502409r
Europe PMC | doi

Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R, Svergun DI, Round A, Oegema K, Dong G. (2014)
Structure of the C. elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases
Structure doi:10.1016/j.str.2014.05.009
Europe PMC | doi

Syson K, Stevenson CEM, Rashid AM, Saalbach G, Tang MH, Tuukkanen A, Svergun DI, Withers SG, Lawson DM, Bornemann S. (2014)
Structural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds alpha-Maltose 1-Phosphate and Forms a Maltosyl-enzyme Intermediate
BIOCHEMISTRY-US 53(15):2494-2504. doi:10.1021/bi500183c
doi

Syson K, Stevenson CE, Rashid AM, Saalbach G, Tang M, Tuukkanen A, Svergun DI, Withers SG, Lawson DM, Bornemann S. (2014)
Structural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds α-Maltose 1-Phosphate and Forms a Maltosyl-enzyme Intermediate
Biochemistry 53(15):2494-2504. doi:10.1021/bi500183c
Europe PMC | doi

Tuukkanen AT, Svergun DI. (2014)
Weak protein-ligand interactions studied by small-angle X-ray scattering
FEBS J. 281(8):1974-1987. doi:10.1111/febs.12772
Europe PMC | doi

Malecki PH, Vorgias CE, Petoukhov MV, Svergun DI, Rypniewski W. (2014)
Crystal structures of substrate-bound chitinase from the psychrophilic bacterium Moritella marina and its structure in solution
Acta Crystallogr. D Biol. Crystallogr. 70(Pt 3):676-684. doi:10.1107/s1399004713032264
Europe PMC | doi

Bonanomi M, Mazzucchelli S, D'Urzo A, Nardini M, Konarev PV, Invernizzi G, Svergun DI, Vanoni M, Regonesi ME, Tortora P. (2014)
Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome
Int. J. Biochem. Cell Biol. doi:10.1016/j.biocel.2014.03.015
Europe PMC | doi

Moglianetti M, Ong QK, Reguera J, Harkness KM, Mameli M, Radulescu A, Kohlbrecher J, Jud C, Svergun DI, Stellacci F. (2014)
Scanning tunneling microscopy and small angle neutron scattering study of mixed monolayer protected gold nanoparticles in organic solvents
CHEM SCI 5(3):1232-1240. doi:10.1039/c3sc52595c
doi

Bowman A, Hammond CM, Stirling A, Ward R, Shang W, El-Mkami H, Robinson DA, Svergun DI, Norman DG, Owen-Hughes T. (2014)
The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution
Nucleic Acids Res. 42(9):6038-6051. doi:10.1093/nar/gku232
Europe PMC | doi

De D, Jeong MH, Leem YE, Svergun DI, Wemmer DE, Kang JS, Kim KK, Kim SH. (2014)
Inhibition of master transcription factors in pluripotent cells induces early stage differentiation
Proc. Natl. Acad. Sci. U.S.A. 111(5):1778-1783. doi:10.1073/pnas.1323386111
Europe PMC | doi

Magbanua E, Konarev PV, Svergun DI, Hahn U. (2014)
Exploring RNA oligomerization and ligand binding by fluorescence correlation spectroscopy and small angle X-ray scattering
Methods Mol. Biol. 1086:321-334. doi:10.1007/978-1-62703-667-2_19
Europe PMC | doi

Konarev PV, Kachalova GS, Ryazanova AY, Kubareva EA, Karyagina AS, Bartunik HD, Svergun DI. (2014)
Flexibility of the Linker between the Domains of DNA Methyltransferase SsoII Revealed by Small-Angle X-Ray Scattering: Implications for Transcription Regulation in SsoII Restriction-Modification System
PLoS ONE 9(4):e93453. doi:10.1371/journal.pone.0093453
Europe PMC | doi

Varadi M, Kosol S, Lebrun P, Valentini E, Blackledge M, Dunker AK, Felli IC, Forman-Kay JD, Kriwacki RW, Pierattelli R, Sussman J, Svergun DI, Uversky VN, Vendruscolo M, Wishart D, Wright PE, Tompa P. (2014)
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins
Nucleic Acids Res. 42(Database issue):D326-35. doi:10.1093/nar/gkt960
Europe PMC | doi

Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A. (2014)
Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae
mBio 5(1):e01120-13. doi:10.1128/mBio.01120-13
Europe PMC | doi

Otrelo-Cardoso AR, da Silva Correia MA, Schwuchow V, Svergun DI, Romão MJ, Leimkühler S, Santos-Silva T. (2014)
Structural data on the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli: SAXS and preliminary X-ray crystallography analysis
Int J Mol Sci 15(2):2223-2236. doi:10.3390/ijms15022223
Europe PMC | doi

Wilmanns M, Svergun DI. (2014)
The 11th International Conference on Biology and Synchrotron Radiation
J Synchrotron Radiat 21(Pt 1):280-282. doi:10.1107/s1600577513030609
Europe PMC | doi

Schulte T, Lofling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, Ebel C, Normark S, Svergun D, Henriques-Normark B, Achour A. (2014)
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold
OPEN BIOL 4(1) doi:10.1098/rsob.130090
Europe PMC | doi

Duelli A, Kiss B, Lundholm I, Bodor A, Petoukhov MV, Svergun DI, Nyitray L, Katona G. (2014)
The C-terminal random coil region tunes the Ca²⁺-binding affinity of S100A4 through conformational activation.
PLoS ONE 9(5) doi:10.1371/journal.pone.0097654
Europe PMC | doi


2013

Shtykova EV, Kabachii YA, Valetsky PM, Kochev SS, Malyutin AG, Stein BD, Bronstein LM, Svergun DI. (2013)
Solution study of novel diblock copolymers: Morphology and structural transition
POLYMER 54(26):6971-6978. doi:10.1016/j.polymer.2013.10.047
doi

Begum A, Drebes J, Kikhney A, Müller IB, Perbandt M, Svergun D, Wrenger C, Betzel C. (2013)
Staphylococcus aureus thiaminase II: oligomerization warrants proteolytic protection against serine proteases
Acta Crystallogr. D Biol. Crystallogr. 69(Pt 12):2320-2329. doi:10.1107/s0907444913021550
Europe PMC | doi

Filippov SK, Franklin JM, Konarev PV, Chytil P, Etrych T, Bogomolova A, Dyakonova M, Papadakis CM, Radulescu A, Ulbrich K, Stepanek P, Svergun DI. (2013)
Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study
Biomacromolecules 14(11):4061-4070. doi:10.1021/bm401186z
Europe PMC | doi

Svergun DI, Koch MHJ, Timmins PA, May RP. (2013)
Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules
IUCr Monographs on Crystallography. Oxford Univ Pr.doi:10.1093/acprof:oso/9780199639533.001.0001
doi

Giganti D, Alegre-Cebollada J, Urresti S, Albesa-Jové D, Rodrigo-Unzueta A, Comino N, Kachala M, López-Fernández S, Svergun DI, Fernández JM, Guerin ME. (2013)
Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria
J. Biol. Chem. 288(41):29797-29808. doi:10.1074/jbc.m113.462705
Europe PMC | doi

Cerofolini L, Fields GB, Fragai M, Geraldes CF, Luchinat C, Parigi G, Ravera E, Svergun DI, Teixeira JM. (2013)
Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state
J. Biol. Chem. 288(42):30659-30671. doi:10.1074/jbc.m113.477240
Europe PMC | doi

Graewert MA, Svergun DI. (2013)
Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS)
Curr. Opin. Struct. Biol. 23(5):748-754. doi:10.1016/j.sbi.2013.06.007
Europe PMC | doi

Petoukhov MV, Billas IM, Takacs M, Graewert MA, Moras D, Svergun DI. (2013)
Reconstruction of quaternary structure from X-ray scattering by equilibrium mixtures of biological macromolecules
Biochemistry 52(39):6844-6855. doi:10.1021/bi400731u
Europe PMC | doi

Sander B, Tria G, Shkumatov AV, Kim EY, Grossmann JG, Tessmer I, Svergun DI, Schindelin H. (2013)
Structural characterization of gephyrin by AFM and SAXS reveals a mixture of compact and extended states
Acta Crystallogr. D Biol. Crystallogr. 69(Pt 10):2050-2060. doi:10.1107/s0907444913018714
Europe PMC | doi

Koch C, Tria G, Fielding AJ, Brodhun F, Valerius O, Feussner K, Braus GH, Svergun DI, Bennati M, Feussner I. (2013)
A structural model of PpoA derived from SAXS-analysis-implications for substrate conversion
Biochim. Biophys. Acta 1831(9):1449-1457. doi:10.1016/j.bbalip.2013.06.003
Europe PMC | doi

Groothuizen FS, Fish A, Petoukhov MV, Reumer A, Manelyte L, Winterwerp HH, Marinus MG, Lebbink JH, Svergun DI, Friedhoff P, Sixma TK. (2013)
Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation
Nucleic Acids Res. 41(17):8166-8181. doi:10.1093/nar/gkt582
Europe PMC | doi

Yan R, Konarev PV, Iannuzzi C, Adinolfi S, Roche B, Kelly G, Simon L, Martin SR, Py B, Barras F, Svergun DI, Pastore A. (2013)
Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS
J. Biol. Chem. 288(34):24777-24787. doi:10.1074/jbc.m113.480327
Europe PMC | doi

Dölker N, Blanchet CE, Voß B, Haselbach D, Kappel C, Monecke T, Svergun DI, Stark H, Ficner R, Zachariae U, Grubmüller H, Dickmanns A. (2013)
Structural determinants and mechanism of mammalian CRM1 allostery
Structure 21(8):1350-1360. doi:10.1016/j.str.2013.05.015
Europe PMC | doi

Trewhella J, Hendrickson WA, Kleywegt GJ, Sali A, Sato M, Schwede T, Svergun DI, Tainer JA, Westbrook J, Berman HM. (2013)
Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB
Structure 21(6):875-881. doi:10.1016/j.str.2013.04.020
Europe PMC | doi

Felix J, Elegheert J, Gutsche I, Shkumatov AV, Wen Y, Bracke N, Pannecoucke E, Vandenberghe I, Devreese B, Svergun DI, Pauwels E, Vergauwen B, Savvides SN. (2013)
Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor
Structure 21(4):528-539. doi:10.1016/j.str.2013.01.018
Europe PMC | doi

Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M. (2013)
Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
Nucleic Acids Res. 41(6):3874-3887. doi:10.1093/nar/gkt053
Europe PMC | doi

de Chiara C, Rees M, Menon RP, Pauwels K, Lawrence C, Konarev PV, Svergun DI, Martin SR, Chen YW, Pastore A. (2013)
Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold
Biophys. J. 104(6):1304-1313. doi:10.1016/j.bpj.2013.01.048
Europe PMC | doi

Söderberg CA, Rajan S, Shkumatov AV, Gakh O, Schaefer S, Ahlgren EC, Svergun DI, Isaya G, Al-Karadaghi S. (2013)
The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization
J. Biol. Chem. 288(12):8156-8167. doi:10.1074/jbc.m112.442285
Europe PMC | doi

Petoukhov MV, Svergun DI. (2013)
Applications of small-angle X-ray scattering to biomacromolecular solutions
Int. J. Biochem. Cell Biol. 45(2):429-437. doi:10.1016/j.biocel.2012.10.017
Europe PMC | doi

Mehtälä ML, Haataja TJ, Blanchet CE, Hiltunen JK, Svergun DI, Glumoff T. (2013)
Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering
FEBS Lett. 587(4):305-310. doi:10.1016/j.febslet.2012.12.014
Europe PMC | doi

Sayers Z, Aydin M, Bal E, Yesilirmak F, Konarev PV, Petoukhov MV, Roessle M, Kikhney AG, Shang WF, Svergun DI. (2013)
Comparative Characterization of Apo-, Reconstituted- and In Vivo-Folded forms of a Durum Wheat Metallothionein
Biophys J 104(2):396A. doi:10.1016/j.bpj.2012.11.2209
doi

Samygina VR, Sokolov AV, Bourenkov G, Petoukhov MV, Pulina MO, Zakharova ET, Vasilyev VB, Bartunik H, Svergun DI. (2013)
Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins
PLoS ONE 8(7):e67145. doi:10.1371/journal.pone.0067145
Europe PMC | doi

Koehler C, Round A, Simader H, Suck D, Svergun D. (2013)
Quaternary structure of the yeast Arc1p-aminoacyl-tRNA synthetase complex in solution and its compaction upon binding of tRNAs
Nucleic Acids Res. 41(1):667-676. doi:10.1093/nar/gks1072
Europe PMC | doi

Blanchet CE, Svergun DI. (2013)
Small-angle X-ray scattering on biological macromolecules and nanocomposites in solution
Annu Rev Phys Chem 64:37-54. doi:10.1146/annurev-physchem-040412-110132
Europe PMC | doi

Shtykova EV, Baratova LA, Fedorova NV, Radyukhin VA, Ksenofontov AL, Volkov VV, Shishkov AV, Dolgov AA, Shilova LA, Batishchev OV, Jeffries CM, Svergun DI. (2013)
Structural analysis of influenza A virus matrix protein M1 and its self-assemblies at low pH
PLoS ONE 8(12):e82431. doi:10.1371/journal.pone.0082431
Europe PMC | doi

Lamber EP, Beuron F, Morris EP, Svergun DI, Mittnacht S. (2013)
Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein
PLoS ONE 8(3):e58463. doi:10.1371/journal.pone.0058463
Europe PMC | doi

Takacs M, Petoukhov MV, Atkinson RA, Roblin P, Ogi FX, Demeler B, Potier N, Chebaro Y, Dejaegere A, Svergun DI, Moras D, Billas IM. (2013)
The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism
PLoS ONE 8(7):e67810. doi:10.1371/journal.pone.0067810
Europe PMC | doi


2012

Makou E, Mertens HD, Maciejewski M, Soares DC, Matis I, Schmidt CQ, Herbert AP, Svergun DI, Barlow PN. (2012)
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H
J. Mol. Biol. 424(5):295-312. doi:10.1016/j.jmb.2012.09.013
Europe PMC | doi

Bunney TD, Esposito D, Mas-Droux C, Lamber E, Baxendale RW, Martins M, Cole A, Svergun D, Driscoll PC, Katan M. (2012)
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation
Structure 20(12):2062-2075. doi:10.1016/j.str.2012.09.005
Europe PMC | doi

Wassenaar TA, van Dijk M, Loureiro-Ferreira N, van der Schot G, de Vries JA, Schmitz C, van der Zwan J, Boelens R, Giachetti A, Ferella L, Rosato A, Bertini I, Herrmann T, Jonker HRA, Bagaria A, Jaravine V, Güntert P, Schwalbe H, Vranken WF, Doreleijers JF, Vriend G, Vuister GW, Franke D, Kikhney A, Svergun DI, Fogh RH, Ionides J, Laue ED, Spronk C, Jurkša S, Verlato M, Badoer S, Dal Pra S, Mazzucato M, Frizziero E, Bonvin AMJJ. (2012)
WeNMR: Structural Biology on the Grid
J Grid Comp 10(4):743-767. doi:10.1007/s10723-012-9246-z
Europe PMC | doi

Mertens HD, Kjaergaard M, Mysling S, Gårdsvoll H, Jørgensen TJ, Svergun DI, Ploug M. (2012)
A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)
J. Biol. Chem. 287(41):34304-34315. doi:10.1074/jbc.m112.398404
Europe PMC | doi

Elegheert J, Bracke N, Pouliot P, Gutsche I, Shkumatov AV, Tarbouriech N, Verstraete K, Bekaert A, Burmeister WP, Svergun DI, Lambrecht BN, Vergauwen B, Savvides SN. (2012)
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Nat. Struct. Mol. Biol. 19(9):938-947. doi:10.1038/nsmb.2367
Europe PMC | doi

Ribeiro Ede A Jr, Beich-Frandsen M, Konarev PV, Shang W, Vecerek B, Kontaxis G, Hämmerle H, Peterlik H, Svergun DI, Bläsi U, Djinović-Carugo K. (2012)
Structural flexibility of RNA as molecular basis for Hfq chaperone function
Nucleic Acids Res. 40(16):8072-8084. doi:10.1093/nar/gks510
Europe PMC | doi

Chen MW, Kotaka M, Vonrhein C, Bricogne G, Rao F, Chuah ML, Svergun D, Schneider G, Liang ZX, Lescar J. (2012)
Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling
J. Bacteriol. 194(18):4837-4846. doi:10.1128/jb.00560-12
Europe PMC | doi

Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED. (2012)
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4
J. Mol. Biol. 422(1):3-17. doi:10.1016/j.jmb.2012.04.031
Europe PMC | doi

Mosbæk CR, Konarev PV, Svergun DI, Rischel C, Vestergaard B. (2012)
High concentration formulation studies of an IgG2 antibody using small angle X-ray scattering
Pharm. Res. 29(8):2225-2235. doi:10.1007/s11095-012-0751-3
Europe PMC | doi

Zoll S, Schlag M, Shkumatov AV, Rautenberg M, Svergun DI, Götz F, Stehle T. (2012)
Ligand-binding properties and conformational dynamics of autolysin repeat domains in staphylococcal cell wall recognition
J. Bacteriol. 194(15):3789-3802. doi:10.1128/jb.00331-12
Europe PMC | doi

Filippov SK, Chytil P, Konarev PV, Dyakonova M, Papadakis C, Zhigunov A, Plestil J, Stepanek P, Etrych T, Ulbrich K, Svergun DI. (2012)
Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system
Biomacromolecules 13(8):2594-2604. doi:10.1021/bm3008555
Europe PMC | doi

Bertini I, Ferella L, Luchinat C, Parigi G, Petoukhov MV, Ravera E, Rosato A, Svergun DI. (2012)
MaxOcc: a web portal for maximum occurrence analysis
J. Biomol. NMR 53(4):271-280. doi:10.1007/s10858-012-9638-1
Europe PMC | doi

Mertens HD, Piljić A, Schultz C, Svergun DI. (2012)
Conformational analysis of a genetically encoded FRET biosensor by SAXS
Biophys. J. 102(12):2866-2875. doi:10.1016/j.bpj.2012.05.009
Europe PMC | doi

Paoletti F, Malerba F, Konarev PV, Visintin M, Scardigli R, Fasulo L, Lamba D, Svergun DI, Cattaneo A. (2012)
Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment
Arch. Biochem. Biophys. 522(1):26-36. doi:10.1016/j.abb.2012.04.003
Europe PMC | doi

Jacques DA, Guss JM, Svergun DI, Trewhella J. (2012)
Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution
Acta Crystallogr. D Biol. Crystallogr. 68(Pt 6):620-626. doi:10.1107/s0907444912012073
Europe PMC | doi

Grela P, Gajda MJ, Armache JP, Beckmann R, Krokowski D, Svergun DI, Grankowski N, Tchórzewski M. (2012)
Solution structure of the natively assembled yeast ribosomal stalk determined by small-angle X-ray scattering
Biochem. J. 444(2):205-209. doi:10.1042/bj20120115
Europe PMC | doi

Shtykoya EV, Kuchkina NV, Shifrina ZB, Bronstein LM, Svergun DI. (2012)
Unusual Structural Morphology of Dendrimer/CdS Nanocomposites Revealed by Synchrotron X-ray Scattering
J PHYS CHEM C 116(14):8069-8078. doi:10.1021/jp210998h
doi

Zou T, Yao X, Qin B, Zhang M, Cai L, Shang W, Svergun DI, Wang M, Cui S, Jin Q. (2012)
Crystal structure of Pseudomonas aeruginosa Tsi2 reveals a stably folded superhelical antitoxin
J. Mol. Biol. 417(4):351-361. doi:10.1016/j.jmb.2012.01.040
Europe PMC | doi

Xiao Y, Ma Q, Restle T, Shang W, Svergun DI, Ponnusamy R, Sczakiel G, Hilgenfeld R. (2012)
Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity
J. Virol. 86(8):4444-4454. doi:10.1128/jvi.06635-11
Europe PMC | doi

Rees M, Gorba C, de Chiara C, Bui TT, Garcia-Maya M, Drake AF, Okazawa H, Pastore A, Svergun D, Chen YW. (2012)
Solution model of the intrinsically disordered polyglutamine tract-binding protein-1
Biophys. J. 102(7):1608-1616. doi:10.1016/j.bpj.2012.02.047
Europe PMC | doi

Redecke L, Sommer A, Elmallah M, Rehders D, Kikhney A, Binder S, Svergun D, Rubhausen M, Betzel C. (2012)
Structural investigation of prion protein conversion induced by oxidative stress
PRION 6:31-32.

Adrover M, Martorell G, Martin SR, Urosev D, Konarev PV, Svergun DI, Daura X, Temussi P, Pastore A. (2012)
The role of hydration in protein stability: comparison of the cold and heat unfolded states of Yfh1
J. Mol. Biol. 417(5):413-424. doi:10.1016/j.jmb.2012.02.002
Europe PMC | doi

Whelan F, Stead JA, Shkumatov AV, Svergun DI, Sanders CM, Antson AA. (2012)
A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding
Nucleic Acids Res. 40(5):2271-2283. doi:10.1093/nar/gkr906
Europe PMC | doi

Ivanov I, Shang W, Toledo L, Masgrau L, Svergun DI, Stehling S, Gómez H, Di Venere A, Mei G, Lluch JM, Skrzypczak-Jankun E, González-Lafont A, Kühn H. (2012)
Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?
Proteins 80(3):703-712. doi:10.1002/prot.23227
Europe PMC | doi

Marrott NL, Marshall JJ, Svergun DI, Crennell SJ, Hough DW, Danson MJ, van den Elsen JM. (2012)
The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly
FEBS J. 279(5):713-723. doi:10.1111/j.1742-4658.2011.08461.x
Europe PMC | doi

Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M. (2012)
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties
PLoS Biol. 10(2):e1001261. doi:10.1371/journal.pbio.1001261
Europe PMC | doi

Strumpfer JA, von Castelmur E, Franke B, Barbieri S, Bogomolovas J, Qadota H, Konarv P, Svergun D, Labeit S, Schulten K, Benian GM, Mayans O. (2012)
Stretching of Twitchin Kinase
BIOPHYS J 102(3):361A-362A.

Bernadó P, Svergun DI. (2012)
Analysis of intrinsically disordered proteins by small-angle X-ray scattering
Methods Mol. Biol. 896:107-122. doi:10.1007/978-1-4614-3704-8_7
Europe PMC | doi

Franke D, Kikhney AG, Svergun DI. (2012)
Automated acquisition and analysis of small angle X-ray scattering data
Nucl Instrum Methods Phys Res A 689:52-59.
Europe PMC

Blanchet CE, Zozulya AV, Kikhney AG, Franke D, Konarev PV, Shang WF, Klaering R, Robrahn B, Hermes C, Cipriani F, Svergun DI, Roessle M. (2012)
Instrumental setup for high-throughput small- and wide-angle solution scattering at the X33 beamline of EMBL Hamburg
J Appl Crystallogr 45:489-495. doi:10.1107/S0021889812013490
Europe PMC | doi

Petoukhov MV, Franke D, Shkumatov AV, Tria G, Kikhney AG, Gajda M, Gorba C, Mertens HDT, Konarev PV, Svergun DI. (2012)
New developments in the ATSAS program package for small-angle scattering data analysis
J Appl Crystallogr 45:342-350. doi:10.1107/S0021889812007662
Europe PMC | doi

Osz J, Pethoukhov MV, Sirigu S, Svergun DI, Moras D, Rochel N. (2012)
Solution Structures of PPARγ2/RXRα Complexes
PPAR Res 2012:701412. doi:10.1155/2012/701412
Europe PMC | doi

Bernadó P, Svergun DI. (2012)
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering
Mol Biosyst 8(1):151-167. doi:10.1039/c1mb05275f
Europe PMC | doi

Morgan HP, Mertens HD, Guariento M, Schmidt CQ, Soares DC, Svergun DI, Herbert AP, Barlow PN, Hannan JP. (2012)
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)
PLoS ONE 7(2):e32187. doi:10.1371/journal.pone.0032187
Europe PMC | doi

Wong E, Vaaje-Kolstad G, Ghosh A, Hurtado-Guerrero R, Konarev PV, Ibrahim AF, Svergun DI, Eijsink VG, Chatterjee NS, van Aalten DM. (2012)
The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces
PLoS Pathog. 8(1):e1002373. doi:10.1371/journal.ppat.1002373
Europe PMC | doi


2011

Schiering N, D'Arcy A, Villard F, Simic O, Kamke M, Monnet G, Hassiepen U, Svergun DI, Pulfer R, Eder J, Raman P, Bodendorf U. (2011)
A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target
Proc. Natl. Acad. Sci. U.S.A. 108(52):21052-21056. doi:10.1073/pnas.1110534108
Europe PMC | doi

Elegheert J, Desfosses A, Shkumatov AV, Wu X, Bracke N, Verstraete K, Van Craenenbroeck K, Brooks BR, Svergun DI, Vergauwen B, Gutsche I, Savvides SN. (2011)
Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles
Structure 19(12):1762-1772. doi:10.1016/j.str.2011.10.012
Europe PMC | doi

Söderberg CA, Shkumatov AV, Rajan S, Gakh O, Svergun DI, Isaya G, Al-Karadaghi S. (2011)
Oligomerization propensity and flexibility of yeast frataxin studied by X-ray crystallography and small-angle X-ray scattering
J. Mol. Biol. 414(5):783-797. doi:10.1016/j.jmb.2011.10.034
Europe PMC | doi

Gorynia S, Bandeiras TM, Pinho FG, McVey CE, Vonrhein C, Round A, Svergun DI, Donner P, Matias PM, Carrondo MA. (2011)
Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex
J. Struct. Biol. 176(3):279-291. doi:10.1016/j.jsb.2011.09.001
Europe PMC | doi

Brunotte L, Kerber R, Shang W, Hauer F, Hass M, Gabriel M, Lelke M, Busch C, Stark H, Svergun DI, Betzel C, Perbandt M, Günther S. (2011)
Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy
J. Biol. Chem. 286(44):38748-38756. doi:10.1074/jbc.m111.278838
Europe PMC | doi

Gráczer E, Konarev PV, Szimler T, Bacsó A, Bodonyi A, Svergun DI, Závodszky P, Vas M. (2011)
Essential role of the metal-ion in the IPM-assisted domain closure of 3-isopropylmalate dehydrogenase
FEBS Lett. 585(20):3297-3302. doi:10.1016/j.febslet.2011.09.013
Europe PMC | doi

Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS. (2011)
Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF
J. Biol. Chem. 286(40):35163-35175. doi:10.1074/jbc.m111.270918
Europe PMC | doi

Sárkány Z, Ikonen TP, Ferreira-da-Silva F, Saraiva MJ, Svergun D, Damas AM. (2011)
Solution structure of the soluble receptor for advanced glycation end products (sRAGE)
J. Biol. Chem. 286(43):37525-37534. doi:10.1074/jbc.m111.223438
Europe PMC | doi

Svergun DI, Shtykova EV, Volkov VV, Feigin LA. (2011)
Small-Angle X-Ray Scattering, Synchrotron Radiation, and the Structure of Bio- and Nanosystems
CRYSTALLOGR REP+ 56(5):725-750. doi:10.1134/S1063774511050221
doi

Sarkany Z, Ikonen T, Ferreira-da-Silva F, Saraiva MJ, Svergun D, Damas AM. (2011)
Solution structure and self assembly properties of soluble RAGE
EUR BIOPHYS J BIOPHY 40:145.

Mehtala M, Haataja T, Blanchet C, Lensink M, Hiltunen K, Svergun D, Glumoff T. (2011)
Structure-function relationships in different MFE-2 proteins by various biophysical techniques
EUR BIOPHYS J BIOPHY 40:139.

Abrahams JP, Apweiler R, Balling R, Bertero MG, Bujnicki JM, Chayen NE, Chène P, Corthals GL, Dyląg T, Förster F, Heck AJ, Henderson PJ, Herwig R, Jehenson P, Kokalj SJ, Laue E, Legrain P, Martens L, Migliorini C, Musacchio A, Podobnik M, Schertler GF, Schreiber G, Sixma TK, Smit AB, Stuart D, Svergun DI, Taussig MJ. (2011)
"4D Biology for health and disease" workshop report
N Biotechnol 28(4):291-293. doi:10.1016/j.nbt.2010.10.003
Europe PMC | doi

Verstraete K, Vandriessche G, Januar M, Elegheert J, Shkumatov AV, Desfosses A, Van Craenenbroeck K, Svergun DI, Gutsche I, Vergauwen B, Savvides SN. (2011)
Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex
Blood 118(1):60-68. doi:10.1182/blood-2011-01-329532
Europe PMC | doi

Shkumatov AV, Chinnathambi S, Mandelkow E, Svergun DI. (2011)
Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering
Proteins 79(7):2122-2131. doi:10.1002/prot.23033
Europe PMC | doi

Shang W, Ivanov I, Svergun DI, Borbulevych OY, Aleem AM, Stehling S, Jankun J, Kühn H, Skrzypczak-Jankun E. (2011)
Probing dimerization and structural flexibility of mammalian lipoxygenases by small-angle X-ray scattering
J. Mol. Biol. 409(4):654-668. doi:10.1016/j.jmb.2011.04.035
Europe PMC | doi

Beich-Frandsen M, Vecerek B, Konarev PV, Sjöblom B, Kloiber K, Hämmerle H, Rajkowitsch L, Miles AJ, Kontaxis G, Wallace BA, Svergun DI, Konrat R, Bläsi U, Djinovic-Carugo K. (2011)
Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq
Nucleic Acids Res. 39(11):4900-4915. doi:10.1093/nar/gkq1346
Europe PMC | doi