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Staff at EMBL


Dr. Dmitri Svergun

Group Leader and Senior Scientist
Svergun Group

EMBL Hamburg c/o DESY, Notkestraße 85, 22603 Hamburg, Germany

E-mail: send a mail


PhD 1982, Dr. of Science 1997, Institute of Crystallography, Moscow.
At EMBL since 1991.
Group leader since 2003.
Senior scientist since 2011.


Total: 351 publication(s)


Hagelueken G, Clarke BR, Huang H, Tuukkanen A, Danciu I, Svergun DI, Hussain R, Liu H, Whitfield C, Naismith JH. (2014)
A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide
Nature Structural & Molecular Biology doi:10.1038/nsmb.2935

Lamontanara AJ, Georgeon S, Tria G, Svergun DI, Hantschel O. (2014)
The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility.
Nat Commun 5 doi:10.1038/ncomms6470
Europe PMC | doi

Ribeiro ED Jr, Pinotsis N, Ghisleni A, Salmazo A, Konarev PV, Kostan J, Sjöblom B, Schreiner C, Polyansky AA, Gkougkoulia EA, Holt MR, Aachmann FL, Zagrović B, Bordignon E, Pirker KF, Svergun DI, Gautel M, Djinović-Carugo K. (2014)
The Structure and Regulation of Human Muscle α-Actinin.
Cell doi:10.1016/j.cell.2014.10.056
Europe PMC | doi

Nilsson OB, Neimert-Andersson T, Bronge M, Grundström J, Sarma R, Uchtenhagen H, Kikhney A, Sandalova T, Holmgren E, Svergun D, Achour A, van Hage M, Grönlund H. (2014)
Designing a multimer allergen for diagnosis and immunotherapy of dog allergic patients.
PLoS ONE 9(10) doi:10.1371/journal.pone.0111041
Europe PMC | doi

Petoukhov MV, Weissenhorn W, Svergun DI. (2014)
Endophilin-A1 BAR domain interaction with arachidonyl CoA
Front Mol Biosci doi:10.3389/fmolb.2014.00020

Valentini E, Kikhney AG, Previtali G, Jeffries CM, Svergun DI. (2014)
SASBDB, a repository for biological small-angle scattering data
Nucleic Acids Res. doi:10.1093/nar/gku1047
Europe PMC | doi

Sachyani D, Dvir M, Strulovich R, Tria G, Tobelaim W, Peretz A, Pongs O, Svergun D, Attali B, Hirsch JA. (2014)
Structural Basis of a Kv7.1 Potassium Channel Gating Module: Studies of the Intracellular C-Terminal Domain in Complex with Calmodulin.
Structure 22(11):1582-1594.
Europe PMC

Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HD, Svergun DI, Zhang Y, Wang JH, Meijers R. (2014)
The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue
Neuron 83(4):839-849. doi:10.1016/j.neuron.2014.07.010
Europe PMC | doi

Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao RP, Svergun DI, Round A, Oegema K, Dong G. (2014)
Structure of the C. elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases
STRUCTURE 22(8):1090-1104. doi:10.1016/j.str.2014.05.009
Europe PMC | doi

Marrott NL, Marshall JJ, Svergun DI, Crennell SJ, Hough DW, van den Elsen JM, Danson MJ. (2014)
Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex.
Biochem. J. 463(3):405-412. doi:10.1042/bj20140359
Europe PMC | doi

Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N. (2014)
A conformational switch in collybistin determines the differentiation of inhibitory postsynapses
EMBO J. 33(18):2113-2133. doi:10.15252/embj.201488143
Europe PMC | doi

Dunne M, Mertens HD, Garefalaki V, Jeffries CM, Thompson A, Lemke EA, Svergun DI, Mayer MJ, Narbad A, Meijers R. (2014)
The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor
PLoS Pathog. 10(7):e1004228. doi:10.1371/journal.ppat.1004228
Europe PMC | doi

Morgan DG, Boris BS, Kuchkina NV, Yuzik-Klimova EY, Sorokina SA, Stein BD, Svergun DI, Spilotros A, Kostopoulou A, Lappas A, Shifrina ZB, Bronstein LM. (2014)
Multicore Iron Oxide Mesocrystals Stabilized by a Poly(phenylenepyridyl) Dendron and Dendrimer: Role of the Dendron/Dendrimer Self-Assembly
LANGMUIR 30(28):8543-8550. doi:10.1021/la502409r
Europe PMC | doi

Morgan DG, Boris BS, Kuchkina NV, Yuzik-Klimova EY, Sorokina S, Stein BD, Svergun DI, Spilotros A, Kostopoulou A, Lappas A, Shifrina ZB, Bronstein LM. (2014)
Multicore Iron Oxide Mesocrystals Stabilized by Polyphe-nylenepyridyl Dendron and Dendrimer: Role of the Den-dron/Dendrimer Self-assembly
Langmuir doi:10.1021/la502409r
Europe PMC | doi

Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R, Svergun DI, Round A, Oegema K, Dong G. (2014)
Structure of the C. elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases
Structure doi:10.1016/j.str.2014.05.009
Europe PMC | doi

Duelli A, Kiss B, Lundholm I, Bodor A, Petoukhov MV, Svergun DI, Nyitray L, Katona G. (2014)
The C-terminal random coil region tunes the Ca²⁺-binding affinity of S100A4 through conformational activation
PLoS ONE 9(5):e97654. doi:10.1371/journal.pone.0097654
Europe PMC | doi

Syson K, Stevenson CEM, Rashid AM, Saalbach G, Tang MH, Tuukkanen A, Svergun DI, Withers SG, Lawson DM, Bornemann S. (2014)
Structural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds alpha-Maltose 1-Phosphate and Forms a Maltosyl-enzyme Intermediate
BIOCHEMISTRY-US 53(15):2494-2504. doi:10.1021/bi500183c
Europe PMC | doi

Syson K, Stevenson CE, Rashid AM, Saalbach G, Tang M, Tuukkanen A, Svergun DI, Withers SG, Lawson DM, Bornemann S. (2014)
Structural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds α-Maltose 1-Phosphate and Forms a Maltosyl-enzyme Intermediate
Biochemistry 53(15):2494-2504. doi:10.1021/bi500183c
Europe PMC | doi

Tuukkanen AT, Svergun DI. (2014)
Weak protein-ligand interactions studied by small-angle X-ray scattering
FEBS J. 281(8):1974-1987. doi:10.1111/febs.12772
Europe PMC | doi

Malecki PH, Vorgias CE, Petoukhov MV, Svergun DI, Rypniewski W. (2014)
Crystal structures of substrate-bound chitinase from the psychrophilic bacterium Moritella marina and its structure in solution
Acta Crystallogr. D Biol. Crystallogr. 70(Pt 3):676-684. doi:10.1107/s1399004713032264
Europe PMC | doi

Bonanomi M, Mazzucchelli S, D'Urzo A, Nardini M, Konarev PV, Invernizzi G, Svergun DI, Vanoni M, Regonesi ME, Tortora P. (2014)
Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome
Int. J. Biochem. Cell Biol. 51:58-64. doi:10.1016/j.biocel.2014.03.015
Europe PMC | doi

Moglianetti M, Ong QK, Reguera J, Harkness KM, Mameli M, Radulescu A, Kohlbrecher J, Jud C, Svergun DI, Stellacci F. (2014)
Scanning tunneling microscopy and small angle neutron scattering study of mixed monolayer protected gold nanoparticles in organic solvents
CHEM SCI 5(3):1232-1240. doi:10.1039/c3sc52595c

Bowman A, Hammond CM, Stirling A, Ward R, Shang W, El-Mkami H, Robinson DA, Svergun DI, Norman DG, Owen-Hughes T. (2014)
The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution
Nucleic Acids Res. 42(9):6038-6051. doi:10.1093/nar/gku232
Europe PMC | doi

De D, Jeong MH, Leem YE, Svergun DI, Wemmer DE, Kang JS, Kim KK, Kim SH. (2014)
Inhibition of master transcription factors in pluripotent cells induces early stage differentiation
Proc. Natl. Acad. Sci. U.S.A. 111(5):1778-1783. doi:10.1073/pnas.1323386111
Europe PMC | doi

Magbanua E, Konarev PV, Svergun DI, Hahn U. (2014)
Exploring RNA oligomerization and ligand binding by fluorescence correlation spectroscopy and small angle X-ray scattering
Methods Mol. Biol. 1086:321-334. doi:10.1007/978-1-62703-667-2_19
Europe PMC | doi

Konarev PV, Kachalova GS, Ryazanova AY, Kubareva EA, Karyagina AS, Bartunik HD, Svergun DI. (2014)
Flexibility of the Linker between the Domains of DNA Methyltransferase SsoII Revealed by Small-Angle X-Ray Scattering: Implications for Transcription Regulation in SsoII Restriction-Modification System
PLoS ONE 9(4):e93453. doi:10.1371/journal.pone.0093453
Europe PMC | doi

Varadi M, Kosol S, Lebrun P, Valentini E, Blackledge M, Dunker AK, Felli IC, Forman-Kay JD, Kriwacki RW, Pierattelli R, Sussman J, Svergun DI, Uversky VN, Vendruscolo M, Wishart D, Wright PE, Tompa P. (2014)
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins
Nucleic Acids Res. 42(Database issue):D326-35. doi:10.1093/nar/gkt960
Europe PMC | doi

Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A. (2014)
Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae
mBio 5(1):e01120-13. doi:10.1128/mBio.01120-13
Europe PMC | doi

Otrelo-Cardoso AR, da Silva Correia MA, Schwuchow V, Svergun DI, Romão MJ, Leimkühler S, Santos-Silva T. (2014)
Structural data on the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli: SAXS and preliminary X-ray crystallography analysis
Int J Mol Sci 15(2):2223-2236. doi:10.3390/ijms15022223
Europe PMC | doi

Wilmanns M, Svergun DI. (2014)
The 11th International Conference on Biology and Synchrotron Radiation
J Synchrotron Radiat 21(Pt 1):280-282. doi:10.1107/s1600577513030609
Europe PMC | doi

Schulte T, Lofling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, Ebel C, Normark S, Svergun D, Henriques-Normark B, Achour A. (2014)
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold
OPEN BIOL 4(1):130090. doi:10.1098/rsob.130090
Europe PMC | doi


Shtykova EV, Kabachii YA, Valetsky PM, Kochev SS, Malyutin AG, Stein BD, Bronstein LM, Svergun DI. (2013)
Solution study of novel diblock copolymers: Morphology and structural transition
POLYMER 54(26):6971-6978. doi:10.1016/j.polymer.2013.10.047

Begum A, Drebes J, Kikhney A, Müller IB, Perbandt M, Svergun D, Wrenger C, Betzel C. (2013)
Staphylococcus aureus thiaminase II: oligomerization warrants proteolytic protection against serine proteases
Acta Crystallogr. D Biol. Crystallogr. 69(Pt 12):2320-2329. doi:10.1107/s0907444913021550
Europe PMC | doi

Filippov SK, Franklin JM, Konarev PV, Chytil P, Etrych T, Bogomolova A, Dyakonova M, Papadakis CM, Radulescu A, Ulbrich K, Stepanek P, Svergun DI. (2013)
Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study
Biomacromolecules 14(11):4061-4070. doi:10.1021/bm401186z
Europe PMC | doi

Svergun DI, Koch MHJ, Timmins PA, May RP. (2013)
Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules
IUCr Monographs on Crystallography. Oxford Univ Pr.doi:10.1093/acprof:oso/9780199639533.001.0001

Giganti D, Alegre-Cebollada J, Urresti S, Albesa-Jové D, Rodrigo-Unzueta A, Comino N, Kachala M, López-Fernández S, Svergun DI, Fernández JM, Guerin ME. (2013)
Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria
J. Biol. Chem. 288(41):29797-29808. doi:10.1074/jbc.m113.462705
Europe PMC | doi

Cerofolini L, Fields GB, Fragai M, Geraldes CF, Luchinat C, Parigi G, Ravera E, Svergun DI, Teixeira JM. (2013)
Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state
J. Biol. Chem. 288(42):30659-30671. doi:10.1074/jbc.m113.477240
Europe PMC | doi

Graewert MA, Svergun DI. (2013)
Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS)
Curr. Opin. Struct. Biol. 23(5):748-754. doi:10.1016/
Europe PMC | doi

Petoukhov MV, Billas IM, Takacs M, Graewert MA, Moras D, Svergun DI. (2013)
Reconstruction of quaternary structure from X-ray scattering by equilibrium mixtures of biological macromolecules
Biochemistry 52(39):6844-6855. doi:10.1021/bi400731u
Europe PMC | doi

Sander B, Tria G, Shkumatov AV, Kim EY, Grossmann JG, Tessmer I, Svergun DI, Schindelin H. (2013)
Structural characterization of gephyrin by AFM and SAXS reveals a mixture of compact and extended states
Acta Crystallogr. D Biol. Crystallogr. 69(Pt 10):2050-2060. doi:10.1107/s0907444913018714
Europe PMC | doi

Koch C, Tria G, Fielding AJ, Brodhun F, Valerius O, Feussner K, Braus GH, Svergun DI, Bennati M, Feussner I. (2013)
A structural model of PpoA derived from SAXS-analysis-implications for substrate conversion
Biochim. Biophys. Acta 1831(9):1449-1457. doi:10.1016/j.bbalip.2013.06.003
Europe PMC | doi

Groothuizen FS, Fish A, Petoukhov MV, Reumer A, Manelyte L, Winterwerp HH, Marinus MG, Lebbink JH, Svergun DI, Friedhoff P, Sixma TK. (2013)
Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation
Nucleic Acids Res. 41(17):8166-8181. doi:10.1093/nar/gkt582
Europe PMC | doi

Yan R, Konarev PV, Iannuzzi C, Adinolfi S, Roche B, Kelly G, Simon L, Martin SR, Py B, Barras F, Svergun DI, Pastore A. (2013)
Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS
J. Biol. Chem. 288(34):24777-24787. doi:10.1074/jbc.m113.480327
Europe PMC | doi

Dölker N, Blanchet CE, Voß B, Haselbach D, Kappel C, Monecke T, Svergun DI, Stark H, Ficner R, Zachariae U, Grubmüller H, Dickmanns A. (2013)
Structural determinants and mechanism of mammalian CRM1 allostery
Structure 21(8):1350-1360. doi:10.1016/j.str.2013.05.015
Europe PMC | doi

Trewhella J, Hendrickson WA, Kleywegt GJ, Sali A, Sato M, Schwede T, Svergun DI, Tainer JA, Westbrook J, Berman HM. (2013)
Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB
Structure 21(6):875-881. doi:10.1016/j.str.2013.04.020
Europe PMC | doi

Felix J, Elegheert J, Gutsche I, Shkumatov AV, Wen Y, Bracke N, Pannecoucke E, Vandenberghe I, Devreese B, Svergun DI, Pauwels E, Vergauwen B, Savvides SN. (2013)
Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor
Structure 21(4):528-539. doi:10.1016/j.str.2013.01.018
Europe PMC | doi

Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M. (2013)
Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
Nucleic Acids Res. 41(6):3874-3887. doi:10.1093/nar/gkt053
Europe PMC | doi

de Chiara C, Rees M, Menon RP, Pauwels K, Lawrence C, Konarev PV, Svergun DI, Martin SR, Chen YW, Pastore A. (2013)
Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold
Biophys. J. 104(6):1304-1313. doi:10.1016/j.bpj.2013.01.048
Europe PMC | doi

Söderberg CA, Rajan S, Shkumatov AV, Gakh O, Schaefer S, Ahlgren EC, Svergun DI, Isaya G, Al-Karadaghi S. (2013)
The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization
J. Biol. Chem. 288(12):8156-8167. doi:10.1074/jbc.m112.442285
Europe PMC | doi

Petoukhov MV, Svergun DI. (2013)
Applications of small-angle X-ray scattering to biomacromolecular solutions
Int. J. Biochem. Cell Biol. 45(2):429-437. doi:10.1016/j.biocel.2012.10.017
Europe PMC | doi

Mehtälä ML, Haataja TJ, Blanchet CE, Hiltunen JK, Svergun DI, Glumoff T. (2013)
Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering
FEBS Lett. 587(4):305-310. doi:10.1016/j.febslet.2012.12.014
Europe PMC | doi

Sayers Z, Aydin M, Bal E, Yesilirmak F, Konarev PV, Petoukhov MV, Roessle M, Kikhney AG, Shang WF, Svergun DI. (2013)
Comparative Characterization of Apo-, Reconstituted- and In Vivo-Folded forms of a Durum Wheat Metallothionein
Biophys J 104(2):396A. doi:10.1016/j.bpj.2012.11.2209

Samygina VR, Sokolov AV, Bourenkov G, Petoukhov MV, Pulina MO, Zakharova ET, Vasilyev VB, Bartunik H, Svergun DI. (2013)
Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins
PLoS ONE 8(7):e67145. doi:10.1371/journal.pone.0067145
Europe PMC | doi

Koehler C, Round A, Simader H, Suck D, Svergun D. (2013)
Quaternary structure of the yeast Arc1p-aminoacyl-tRNA synthetase complex in solution and its compaction upon binding of tRNAs
Nucleic Acids Res. 41(1):667-676. doi:10.1093/nar/gks1072
Europe PMC | doi

Blanchet CE, Svergun DI. (2013)
Small-angle X-ray scattering on biological macromolecules and nanocomposites in solution
Annu Rev Phys Chem 64:37-54. doi:10.1146/annurev-physchem-040412-110132
Europe PMC | doi

Shtykova EV, Baratova LA, Fedorova NV, Radyukhin VA, Ksenofontov AL, Volkov VV, Shishkov AV, Dolgov AA, Shilova LA, Batishchev OV, Jeffries CM, Svergun DI. (2013)
Structural analysis of influenza A virus matrix protein M1 and its self-assemblies at low pH
PLoS ONE 8(12):e82431. doi:10.1371/journal.pone.0082431
Europe PMC | doi

Lamber EP, Beuron F, Morris EP, Svergun DI, Mittnacht S. (2013)
Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein
PLoS ONE 8(3):e58463. doi:10.1371/journal.pone.0058463
Europe PMC | doi

Takacs M, Petoukhov MV, Atkinson RA, Roblin P, Ogi FX, Demeler B, Potier N, Chebaro Y, Dejaegere A, Svergun DI, Moras D, Billas IM. (2013)
The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism
PLoS ONE 8(7):e67810. doi:10.1371/journal.pone.0067810
Europe PMC | doi


Makou E, Mertens HD, Maciejewski M, Soares DC, Matis I, Schmidt CQ, Herbert AP, Svergun DI, Barlow PN. (2012)
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H
J. Mol. Biol. 424(5):295-312. doi:10.1016/j.jmb.2012.09.013
Europe PMC | doi

Bunney TD, Esposito D, Mas-Droux C, Lamber E, Baxendale RW, Martins M, Cole A, Svergun D, Driscoll PC, Katan M. (2012)
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation
Structure 20(12):2062-2075. doi:10.1016/j.str.2012.09.005
Europe PMC | doi

Wassenaar TA, van Dijk M, Loureiro-Ferreira N, van der Schot G, de Vries JA, Schmitz C, van der Zwan J, Boelens R, Giachetti A, Ferella L, Rosato A, Bertini I, Herrmann T, Jonker HRA, Bagaria A, Jaravine V, Güntert P, Schwalbe H, Vranken WF, Doreleijers JF, Vriend G, Vuister GW, Franke D, Kikhney A, Svergun DI, Fogh RH, Ionides J, Laue ED, Spronk C, Jurkša S, Verlato M, Badoer S, Dal Pra S, Mazzucato M, Frizziero E, Bonvin AMJJ. (2012)
WeNMR: Structural Biology on the Grid
J Grid Comp 10(4):743-767. doi:10.1007/s10723-012-9246-z
Europe PMC | doi

Mertens HD, Kjaergaard M, Mysling S, Gårdsvoll H, Jørgensen TJ, Svergun DI, Ploug M. (2012)
A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)
J. Biol. Chem. 287(41):34304-34315. doi:10.1074/jbc.m112.398404
Europe PMC | doi

Elegheert J, Bracke N, Pouliot P, Gutsche I, Shkumatov AV, Tarbouriech N, Verstraete K, Bekaert A, Burmeister WP, Svergun DI, Lambrecht BN, Vergauwen B, Savvides SN. (2012)
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Nat. Struct. Mol. Biol. 19(9):938-947. doi:10.1038/nsmb.2367
Europe PMC | doi

Ribeiro Ede A Jr, Beich-Frandsen M, Konarev PV, Shang W, Vecerek B, Kontaxis G, Hämmerle H, Peterlik H, Svergun DI, Bläsi U, Djinović-Carugo K. (2012)
Structural flexibility of RNA as molecular basis for Hfq chaperone function
Nucleic Acids Res. 40(16):8072-8084. doi:10.1093/nar/gks510
Europe PMC | doi

Chen MW, Kotaka M, Vonrhein C, Bricogne G, Rao F, Chuah ML, Svergun D, Schneider G, Liang ZX, Lescar J. (2012)
Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling
J. Bacteriol. 194(18):4837-4846. doi:10.1128/jb.00560-12
Europe PMC | doi

Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED. (2012)
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4
J. Mol. Biol. 422(1):3-17. doi:10.1016/j.jmb.2012.04.031
Europe PMC | doi

Mosbæk CR, Konarev PV, Svergun DI, Rischel C, Vestergaard B. (2012)
High concentration formulation studies of an IgG2 antibody using small angle X-ray scattering
Pharm. Res. 29(8):2225-2235. doi:10.1007/s11095-012-0751-3
Europe PMC | doi

von Castelmur E, Strümpfer J, Franke B, Bogomolovas J, Barbieri S, Qadota H, Konarev PV, Svergun DI, Labeit S, Benian GM, Schulten K, Mayans O. (2012)
Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase
Proc. Natl. Acad. Sci. U.S.A. 109(34):13608-13613. doi:10.1073/pnas.1200697109
Europe PMC | doi

Zoll S, Schlag M, Shkumatov AV, Rautenberg M, Svergun DI, Götz F, Stehle T. (2012)
Ligand-binding properties and conformational dynamics of autolysin repeat domains in staphylococcal cell wall recognition
J. Bacteriol. 194(15):3789-3802. doi:10.1128/jb.00331-12
Europe PMC | doi

Filippov SK, Chytil P, Konarev PV, Dyakonova M, Papadakis C, Zhigunov A, Plestil J, Stepanek P, Etrych T, Ulbrich K, Svergun DI. (2012)
Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system
Biomacromolecules 13(8):2594-2604. doi:10.1021/bm3008555
Europe PMC | doi

Bertini I, Ferella L, Luchinat C, Parigi G, Petoukhov MV, Ravera E, Rosato A, Svergun DI. (2012)
MaxOcc: a web portal for maximum occurrence analysis
J. Biomol. NMR 53(4):271-280. doi:10.1007/s10858-012-9638-1
Europe PMC | doi

Mertens HD, Piljić A, Schultz C, Svergun DI. (2012)
Conformational analysis of a genetically encoded FRET biosensor by SAXS
Biophys. J. 102(12):2866-2875. doi:10.1016/j.bpj.2012.05.009
Europe PMC | doi

Paoletti F, Malerba F, Konarev PV, Visintin M, Scardigli R, Fasulo L, Lamba D, Svergun DI, Cattaneo A. (2012)
Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment
Arch. Biochem. Biophys. 522(1):26-36. doi:10.1016/
Europe PMC | doi

Jacques DA, Guss JM, Svergun DI, Trewhella J. (2012)
Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution
Acta Crystallogr. D Biol. Crystallogr. 68(Pt 6):620-626. doi:10.1107/s0907444912012073
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Grela P, Gajda MJ, Armache JP, Beckmann R, Krokowski D, Svergun DI, Grankowski N, Tchórzewski M. (2012)
Solution structure of the natively assembled yeast ribosomal stalk determined by small-angle X-ray scattering
Biochem. J. 444(2):205-209. doi:10.1042/bj20120115
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Shtykoya EV, Kuchkina NV, Shifrina ZB, Bronstein LM, Svergun DI. (2012)
Unusual Structural Morphology of Dendrimer/CdS Nanocomposites Revealed by Synchrotron X-ray Scattering
J PHYS CHEM C 116(14):8069-8078. doi:10.1021/jp210998h

Zou T, Yao X, Qin B, Zhang M, Cai L, Shang W, Svergun DI, Wang M, Cui S, Jin Q. (2012)
Crystal structure of Pseudomonas aeruginosa Tsi2 reveals a stably folded superhelical antitoxin
J. Mol. Biol. 417(4):351-361. doi:10.1016/j.jmb.2012.01.040
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Xiao Y, Ma Q, Restle T, Shang W, Svergun DI, Ponnusamy R, Sczakiel G, Hilgenfeld R. (2012)
Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity
J. Virol. 86(8):4444-4454. doi:10.1128/jvi.06635-11
Europe PMC | doi

Rees M, Gorba C, de Chiara C, Bui TT, Garcia-Maya M, Drake AF, Okazawa H, Pastore A, Svergun D, Chen YW. (2012)
Solution model of the intrinsically disordered polyglutamine tract-binding protein-1
Biophys. J. 102(7):1608-1616. doi:10.1016/j.bpj.2012.02.047
Europe PMC | doi

Redecke L, Sommer A, Elmallah M, Rehders D, Kikhney A, Binder S, Svergun D, Rubhausen M, Betzel C. (2012)
Structural investigation of prion protein conversion induced by oxidative stress
PRION 6:31-32.

Adrover M, Martorell G, Martin SR, Urosev D, Konarev PV, Svergun DI, Daura X, Temussi P, Pastore A. (2012)
The role of hydration in protein stability: comparison of the cold and heat unfolded states of Yfh1
J. Mol. Biol. 417(5):413-424. doi:10.1016/j.jmb.2012.02.002
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Whelan F, Stead JA, Shkumatov AV, Svergun DI, Sanders CM, Antson AA. (2012)
A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding
Nucleic Acids Res. 40(5):2271-2283. doi:10.1093/nar/gkr906
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Ivanov I, Shang W, Toledo L, Masgrau L, Svergun DI, Stehling S, Gómez H, Di Venere A, Mei G, Lluch JM, Skrzypczak-Jankun E, González-Lafont A, Kühn H. (2012)
Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?
Proteins 80(3):703-712. doi:10.1002/prot.23227
Europe PMC | doi

Marrott NL, Marshall JJ, Svergun DI, Crennell SJ, Hough DW, Danson MJ, van den Elsen JM. (2012)
The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly
FEBS J. 279(5):713-723. doi:10.1111/j.1742-4658.2011.08461.x
Europe PMC | doi

Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M. (2012)
Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties
PLoS Biol. 10(2):e1001261. doi:10.1371/journal.pbio.1001261
Europe PMC | doi

Strumpfer JA, von Castelmur E, Franke B, Barbieri S, Bogomolovas J, Qadota H, Konarv P, Svergun D, Labeit S, Schulten K, Benian GM, Mayans O. (2012)
Stretching of Twitchin Kinase
BIOPHYS J 102(3):361A-362A.

Bernadó P, Svergun DI. (2012)
Analysis of intrinsically disordered proteins by small-angle X-ray scattering
Methods Mol. Biol. 896:107-122. doi:10.1007/978-1-4614-3704-8_7
Europe PMC | doi

Franke D, Kikhney AG, Svergun DI. (2012)
Automated acquisition and analysis of small angle X-ray scattering data
Nucl Instrum Methods Phys Res A 689:52-59.
Europe PMC

Blanchet CE, Zozulya AV, Kikhney AG, Franke D, Konarev PV, Shang WF, Klaering R, Robrahn B, Hermes C, Cipriani F, Svergun DI, Roessle M. (2012)
Instrumental setup for high-throughput small- and wide-angle solution scattering at the X33 beamline of EMBL Hamburg
J Appl Crystallogr 45:489-495.
Europe PMC

Petoukhov MV, Franke D, Shkumatov AV, Tria G, Kikhney AG, Gajda M, Gorba C, Mertens HDT, Konarev PV, Svergun DI. (2012)
New developments in the ATSAS program package for small-angle scattering data analysis
J Appl Crystallogr 45:342-350.
Europe PMC

Petoukhov MV, Svergun DI. (2012)
Small Angle X-Ray Scattering/Small Angle Neutron Scattering as Methods Complementary to NMR.
In: Bertini I., McGreevy K.S., Parigi G., In NMR of Biomolecules: Towards Mechanistic Systems Biology. Wiley-VCH. pp 563-574.

Osz J, Pethoukhov MV, Sirigu S, Svergun DI, Moras D, Rochel N. (2012)
Solution Structures of PPARγ2/RXRα Complexes
PPAR Res 2012:701412. doi:10.1155/2012/701412
Europe PMC | doi

Bernadó P, Svergun DI. (2012)
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering
Mol Biosyst 8(1):151-167. doi:10.1039/c1mb05275f
Europe PMC | doi

Morgan HP, Mertens HD, Guariento M, Schmidt CQ, Soares DC, Svergun DI, Herbert AP, Barlow PN, Hannan JP. (2012)
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)
PLoS ONE 7(2):e32187. doi:10.1371/journal.pone.0032187
Europe PMC | doi

Wong E, Vaaje-Kolstad G, Ghosh A, Hurtado-Guerrero R, Konarev PV, Ibrahim AF, Svergun DI, Eijsink VG, Chatterjee NS, van Aalten DM. (2012)
The Vibrio cholerae colonization factor GbpA possesses a modular structure that governs binding to different host surfaces
PLoS Pathog. 8(1):e1002373. doi:10.1371/journal.ppat.1002373
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Schiering N, D'Arcy A, Villard F, Simic O, Kamke M, Monnet G, Hassiepen U, Svergun DI, Pulfer R, Eder J, Raman P, Bodendorf U. (2011)
A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target
Proc. Natl. Acad. Sci. U.S.A. 108(52):21052-21056. doi:10.1073/pnas.1110534108
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Elegheert J, Desfosses A, Shkumatov AV, Wu X, Bracke N, Verstraete K, Van Craenenbroeck K, Brooks BR, Svergun DI, Vergauwen B, Gutsche I, Savvides SN. (2011)
Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles
Structure 19(12):1762-1772. doi:10.1016/j.str.2011.10.012
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Söderberg CA, Shkumatov AV, Rajan S, Gakh O, Svergun DI, Isaya G, Al-Karadaghi S. (2011)
Oligomerization propensity and flexibility of yeast frataxin studied by X-ray crystallography and small-angle X-ray scattering
J. Mol. Biol. 414(5):783-797. doi:10.1016/j.jmb.2011.10.034
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Gorynia S, Bandeiras TM, Pinho FG, McVey CE, Vonrhein C, Round A, Svergun DI, Donner P, Matias PM, Carrondo MA. (2011)
Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex
J. Struct. Biol. 176(3):279-291. doi:10.1016/j.jsb.2011.09.001
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Brunotte L, Kerber R, Shang W, Hauer F, Hass M, Gabriel M, Lelke M, Busch C, Stark H, Svergun DI, Betzel C, Perbandt M, Günther S. (2011)
Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy
J. Biol. Chem. 286(44):38748-38756. doi:10.1074/jbc.m111.278838
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