EMBL Hamburg c/o DESY, Notkestraße 85, 22607 Hamburg, Germany

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Biography

  • PhD 1982, Dr. of Science 1997, Institute of Crystallography, Moscow.
    At EMBL since 1991.
    Group leader since 2003.
    Senior scientist since 2011.

Publications

Total: 400 publication(s)

2016

Buetow L, Tria G, Ahmed SF, Hock A, Dou H, Sibbet GJ, Svergun DI, Huang DT. (2016)

Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.

BMC Biol. 14 doi:10.1186/s12915-016-0298-6
Europe PMC | doi

Schulte T, Mikaelsson C, Beaussart A, Kikhney A, Deshmukh M, Wolniak S, Pathak A, Ebel C, Löfling J, Fogolari F, Henriques-Normark B, Dufrêne YF, Svergun D, Nygren PÅ, Achour A. (2016)

The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.

Sci Rep 6 doi:10.1038/srep32371
Europe PMC | doi

Mathiasen L, Valentini E, Boivin S, Cattaneo A, Blasi F, Svergun DI, Bruckmann C. (2016)

The flexibility of a homeodomain transcription factor heterodimer and its allosteric regulation by DNA binding.

FEBS J. doi:10.1111/febs.13801
Europe PMC | doi

Szameit K, Berg K, Kruspe S, Valentini E, Magbanua E, Kwiatkowski M, Chauvot de Beauchêne I, Krichel B, Schamoni K, Uetrecht C, Svergun DI, Schlüter H, Zacharias M, Hahn U. (2016)

Structure and target interaction of a G-quadruplex RNA-aptamer.

RNA Biol doi:http://dx.doi.org/10.1080/15476286.2016.1212151
Europe PMC | doi

Yang X, Wang S, King TL, Kerr CJ, Blanchet C, Svergun D, Pal R, Beeby A, Vadivelu J, Brown KA, Jones RA, Zhang L, Huang S. (2016)

Anisotropic lanthanide-based nano-clusters for imaging applications.

Faraday Discuss. doi:10.1039/c6fd00018e
Europe PMC | doi

Valencia-Sánchez MI, Rodríguez-Hernández A, Ferreira R, Santamaría-Suárez HA, Arciniega M, Dock-Bregeon AC, Moras D, Beinsteiner B, Mertens H, Svergun D, Brieba LG, Grøtli M, Torres-Larios A. (2016)

Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases.

J. Biol. Chem. 291(28):14430-14446. doi:10.1074/jbc.m116.730382
Europe PMC | doi

Berneking L, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney AG, Koch-Nolte F, Buck F, Perbandt M, Betzel C, Svergun DI, Hentschke M, Aepfelbacher M. (2016)

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells.

PLoS Pathog. 12(6):e1005660. doi:10.1371/journal.ppat.1005660
Europe PMC | doi

Liu J, Falke S, Drobot B, Oberthuer D, Kikhney A, Guenther T, Fahmy K, Svergun D, Betzel C, Raff J. (2016)

Analysis of self-assembly of S-layer protein slp-B53 from Lysinibacillus sphaericus.

Eur. Biophys. J. doi:10.1007/s00249-016-1139-9
Europe PMC | doi

Konarev PV, Petoukhov MV, Svergun DI. (2016)

Rapid automated superposition of shapes and macromolecular models using spherical harmonics.

J Appl Crystallogr 49(Pt 3):953-960. doi:10.1107/S1600576716005793
Europe PMC | doi

Bumba L, Masin J, Macek P, Wald T, Motlova L, Bibova I, Klimova N, Bednarova L, Veverka V, Kachala M, Svergun DI, Barinka C, Sebo P. (2016)

Calcium-Driven Folding of RTX Domain β-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts.

Mol. Cell 62(1):47-62. doi:10.1016/j.molcel.2016.03.018
Europe PMC | doi

Schwemmer F, Blanchet CE, Spilotros A, Kosse D, Zehnle S, Mertens HD, Graewert MA, Rössle M, Paust N, Svergun DI, von Stetten F, Zengerle R, Mark D. (2016)

LabDisk for SAXS: a centrifugal microfluidic sample preparation platform for small-angle X-ray scattering.

Lab Chip 16(7):1161-1170. doi:10.1039/c5lc01580d
Europe PMC | doi

Drebes J, Künz M, Windshügel B, Kikhney AG, Müller IB, Eberle RJ, Oberthür D, Cang H, Svergun DI, Perbandt M, Betzel C, Wrenger C. (2016)

Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.

Sci Rep 6 doi:10.1038/srep22871
Europe PMC | doi

Plath F, Ringler P, Graff-Meyer A, Stahlberg H, Lauer ME, Rufer AC, Graewert MA, Svergun D, Gellermann G, Finkler C, Stracke JO, Koulov A, Schnaible V. (2016)

Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs.

MAbs doi:10.1080/19420862.2016.1168960
Europe PMC | doi

Boer DR, Ruiz-Masó JA, Rueda M, Petoukhov MV, Machón C, Svergun DI, Orozco M, Del Solar G, Coll M. (2016)

Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158.

Sci Rep 6 doi:10.1038/srep20915
Europe PMC | doi

Kachala M, Westbrook J, Svergun D. (2016)

Extension of the sasCIF format and its applications for data processing and deposition.

J Appl Crystallogr 49(Pt 1):302-310. doi:10.1107/S1600576715024942
Europe PMC | doi

Panjkovich A, Svergun DI. (2016)

SASpy: a PyMOL plugin for manipulation and refinement of hybrid models against small angle X-ray scattering data.

Bioinformatics doi:10.1093/bioinformatics/btw071
Europe PMC | doi

Kikhney AG, Panjkovich A, Sokolova AV, Svergun DI. (2016)

DARA: a web server for rapid search of structural neighbours using solution small angle X-ray scattering data.

Bioinformatics 32(4):616-618. doi:10.1093/bioinformatics/btv611
Europe PMC | doi

Panjkovich A, Svergun DI. (2016)

Deciphering conformational transitions of proteins by small angle X-ray scattering and normal mode analysis.

Phys Chem Chem Phys 18(8):5707-5719. doi:10.1039/c5cp04540a
Europe PMC | doi


2015

Albesa-Jové D, Comino N, Tersa M, Mohorko E, Urresti S, Dainese E, Chiarelli LR, Pasca MR, Manganelli R, Makarov V, Riccardi G, Svergun DI, Glockshuber R, Guerin ME. (2015)

The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.

J. Biol. Chem. 290(52):31077-31089. doi:10.1074/jbc.M115.677039
Europe PMC | doi

Dunne M, Leicht S, Krichel B, Mertens HD, Thompson A, Krijgsveld J, Svergun DI, Gómez-Torres N, Garde S, Uetrecht C, Narbad A, Mayer MJ, Meijers R. (2015)

Crystal structure of the CTP1L endolysin reveals how its activity is regulated by a secondary translation product.

J. Biol. Chem. doi:10.1074/jbc.M115.671172
Europe PMC | doi

Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE.. (2015)

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.

Nucleic Acids Res. doi:10.1093/nar/gkv987
Europe PMC | doi

Kachala M, Valentini E, Svergun DI. (2015)

Application of SAXS for the Structural Characterization of IDPs.

In: Isabella C. Felli Roberta Pierattelli, Intrinsically Disordered Proteins Studied by NMR Spectroscopy, vol 870. SPRINGER-VERLAG NEW YORK, MS INGRID CUNNINGHAM, 175 FIFTH AVE, NEW YORK, NY 10010 USA. pp 261-289. ADV EXP MED BIOL 870:261-289. doi:10.1007/978-3-319-20164-1_8
doi

Fadouloglou VE, Lin HV, Tria G, Hernández H, Robinson CV, Svergun DI, Luisi BF. (2015)

Maturation of 6S regulatory RNA to a highly elongated structure.

FEBS J doi:10.1111/febs.13516
Europe PMC | doi

Kikhney AG, Svergun DI. (2015)

A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins.

FEBS Lett 589(19 Pt A):2570-2577. doi:10.1016/j.febslet.2015.08.027
Europe PMC | doi

Mittelberger F, Meyer C, Waetzig GH, Zacharias M, Valentini E, Svergun DI, Berg K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U. (2015)

RAID3 - An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity.

RNA Biol 12(9):1043-1053. doi:10.1080/15476286.2015.1079681
Europe PMC | doi

Chen X, Hnida K, Graewert MA, Andersen JT, Iversen R, Tuukkanen A, Svergun D, Sollid LM. (2015)

Structural basis for antigen recognition by transglutaminase 2-specific autoantibodies in celiac disease.

J. Biol. Chem. doi:10.1074/jbc.M115.669895
Europe PMC | doi

Mercadante D, Milles S, Fuertes G, Svergun DI, Lemke EA, Gräter F. (2015)

Kirkwood-Buff Approach Rescues Overcollapse of a Disordered Protein in Canonical Protein Force Fields

J Phys Chem B 119(25):7975-7984. doi:10.1021/acs.jpcb.5b03440
Europe PMC | doi

Sali A, Berman HM, Schwede T, Trewhella J, Kleywegt G, Burley SK, Markley J, Nakamura H, Adams P, Bonvin AM, Chiu W, Peraro MD, Di Maio F, Ferrin TE, Grünewald K, Gutmanas A, Henderson R, Hummer G, Iwasaki K, Johnson G, Lawson CL, Meiler J, Marti-Renom MA, Montelione GT, Nilges M, Nussinov R, Patwardhan A, Rappsilber J, Read RJ, Saibil H, Schröder GF, Schwieters CD, Seidel CA, Svergun D, Topf M, Ulrich EL, Velankar S, Westbrook JD. (2015)

Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop.

Structure doi:10.1016/j.str.2015.05.013
Europe PMC | doi

Malyutin AG, Cheng H, Sanchez-Felix OR, Carlson K, Stein BD, Konarev PV, Svergun DI, Dragnea B, Bronstein LM. (2015)

Coat Protein-Dependent Behavior of Poly(ethylene glycol) Tails in Iron Oxide Core Virus-like Nanoparticles

ACS Appl. Mater. Interfaces 7(22):12089-12098. doi:10.1021/acsami.5b02278
Europe PMC | doi

Škerlová J, Král V, Kachala M, Fábry M, Bumba L, Svergun DI, Tošner Z, Veverka V, Řezáčová P. (2015)

Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85.

J. Struct. Biol. doi:10.1016/j.jsb.2015.06.005
Europe PMC | doi

Graewert MA, Franke D, Jeffries CM, Blanchet CE, Ruskule D, Kuhle K, Flieger A, Schäfer B, Tartsch B, Meijers R, Svergun DI. (2015)

Automated pipeline for purification, biophysical and x-ray analysis of biomacromolecular solutions.

Sci Rep 5 doi:10.1038/srep10734
Europe PMC | doi

Gruszka DT, Whelan F, Farrance OE, Fung HK, Paci E, Jeffries CM, Svergun DI, Baldock C, Baumann CG, Brockwell DJ, Potts JR, Clarke J. (2015)

Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein.

Nat Commun 6 doi:10.1038/ncomms8271
Europe PMC | doi

Petoukhov MV, Svergun DI. (2015)

Ambiguity assessment of small-angle scattering curves from monodisperse systems.

Acta Crystallogr. D Biol. Crystallogr. 71(Pt 5):1051-1058. doi:10.1107/s1399004715002576
Europe PMC | doi

Jiménez-García B, Pons C, Svergun DI, Bernadó P, Fernández-Recio J. (2015)

pyDockSAXS: protein-protein complex structure by SAXS and computational docking.

Nucleic Acids Res. 43(W1):W356-W361. doi:10.1093/nar/gkv368
Europe PMC | doi

Konarev PV, Svergun DI. (2015)

A posteriori determination of the useful data range for small-angle scattering experiments on dilute monodisperse systems.

IUCrJ 2(Pt 3):352-360. doi:10.1107/s2052252515005163
Europe PMC | doi

Franke D, Jeffries CM, Svergun DI. (2015)

Correlation Map, a goodness-of-fit test for one-dimensional X-ray scattering spectra.

Nat Methods 12(5):419-422. doi:10.1038/nmeth.3358
Europe PMC | doi

Langkilde AE, Morris KL, Serpell LC, Svergun DI, Vestergaard B. (2015)

The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

Acta Crystallogr. Sect. D-Biol. Crystallogr. 71:882-895. doi:10.1107/S1399004715001674
Europe PMC | doi

Thomsen M, Tuukkanen A, Dickerhoff J, Palm GJ, Kratzat H, Svergun DI, Weisz K, Bornscheuer UT, Hinrichs W. (2015)

Structure and catalytic mechanism of the evolutionarily unique bacterial chalcone isomerase

Acta Crystallogr. Sect. D-Biol. Crystallogr. 71:907-917. doi:10.1107/S1399004715001935
Europe PMC | doi

Blanchet CE, Spilotros A, Schwemmer F, Graewert MA, Kikhney A, Jeffries CM, Franke D, Mark D, Zengerle R, Cipriani F, Fiedler S, Roessle M, Svergun DI. (2015)

Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline (PETRA III, DESY).

J Appl Crystallogr 48(Pt 2):431-443. doi:10.1107/s160057671500254x
Europe PMC | doi

Song JG, Kostan J, Drepper F, Knapp B, de Almeida Ribeiro E Jr, Konarev PV, Grishkovskaya I, Wiche G, Gregor M, Svergun DI, Warscheid B, Djinović-Carugo K. (2015)

Structural Insights into Ca(2+)-Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes.

Structure 23(3):558-570. doi:10.1016/j.str.2015.01.011
Europe PMC | doi

Blanchet CE, Hermes C, Svergun DI, Fiedler S. (2015)

A small and robust active beamstop for scattering experiments on high-brilliance undulator beamlines.

J Synchrotron Radiat 22(Pt 2):461-464. doi:10.1107/s160057751402829x
Europe PMC | doi

Tria G, Mertens HD, Kachala M, Svergun DI. (2015)

Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering.

IUCrJ 2(Pt 2):207-217. doi:10.1107/s205225251500202x
Europe PMC | doi

Jeffries CM, Graewert MA, Svergun DI, Blanchet CE. (2015)

Limiting radiation damage for high-brilliance biological solution scattering: practical experience at the EMBL P12 beamline PETRAIII

J Synchrotron Radiat 22(Pt 2):273-279. doi:10.1107/S1600577515000375
Europe PMC | doi

Covaceuszach S, Konarev PV, Cassetta A, Paoletti F, Svergun DI, Lamba D, Cattaneo A. (2015)

The Conundrum of the High-Affinity NGF Binding Site Formation Unveiled?

Biophys. J. 108(3):687-697. doi:10.1016/j.bpj.2014.11.3485
Europe PMC | doi

Valentini E, Kikhney AG, Previtali G, Jeffries CM, Svergun DI. (2015)

SASBDB, a repository for biological small-angle scattering data

Nucleic Acids Res. 43(D1):D357-D363. doi:10.1093/nar/gku1047
Europe PMC | doi

Gráczer É, Palló A, Oláh J, Szimler T, Konarev PV, Svergun DI, Merli A, Závodszky P, Weiss MS, Vas M. (2015)

Glutamate 270 plays an essential role in K(+)-activation and domain closure of Thermus thermophilus isopropylmalate dehydrogenase.

FEBS Lett. doi:10.1016/j.febslet.2014.12.005
Europe PMC | doi

Malyutin AG, Easterday R, Lozovyy Y, Spilotros A, Cheng H, Sanchez-Felix OR, Stein BD, Morgan DG, Svergun DI, Dragnea B, Bronstein LM. (2015)

Viruslike Nano Particles with Maghemite Cores Allow for Enhanced MRI Contrast Agents

Chem. Mat. 27(1):327-335. doi:10.1021/cm504029j
doi

Tallant C, Valentini E, Fedorov O, Overvoorde L, Ferguson FM, Filippakopoulos P, Svergun DI, Knapp S, Ciulli A. (2015)

Molecular Basis of Histone Tail Recognition by Human TIP5 PHD Finger and Bromodomain of the Chromatin Remodeling Complex NoRC.

Structure 23(1):80-92. doi:10.1016/j.str.2014.10.017
Europe PMC | doi

De Maria Antolinos A, Pernot P, Brennich ME, Kieffer J, Bowler MW, Delageniere S, Ohlsson S, Malbet Monaco S, Ashton A, Franke D, Svergun D, McSweeney S, Gordon E, Round A. (2015)

ISPyB for BioSAXS, the gateway to user autonomy in solution scattering experiments.

Acta Crystallogr. D Biol. Crystallogr. 71(Pt 1):76-85. doi:10.1107/s1399004714019609
Europe PMC | doi

Jeffries CM, Svergun DI. (2015)

High-throughput studies of protein shapes and interactions by synchrotron small-angle x-ray scattering.

Methods Mol. Biol. 1261:277-301. doi:10.1007/978-1-4939-2230-7_15
Europe PMC | doi

Round A, Felisaz F, Fodinger L, Gobbo A, Huet J, Villard C, Blanchet CE, Pernot P, McSweeney S, Roessle M, Svergun DI, Cipriani F. (2015)

BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments.

Acta Crystallogr. D Biol. Crystallogr. D71(Pt 1):67-75. doi:10.1107/S1399004714026959
Europe PMC | doi


2014

Hagelueken G, Clarke BR, Huang H, Tuukkanen A, Danciu I, Svergun DI, Hussain R, Liu H, Whitfield C, Naismith JH. (2014)

A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide.

Nat. Struct. Mol. Biol. doi:10.1038/nsmb.2935
Europe PMC | doi

Ribeiro ED Jr, Pinotsis N, Ghisleni A, Salmazo A, Konarev PV, Kostan J, Sjöblom B, Schreiner C, Polyansky AA, Gkougkoulia EA, Holt MR, Aachmann FL, Zagrović B, Bordignon E, Pirker KF, Svergun DI, Gautel M, Djinović-Carugo K. (2014)

The Structure and Regulation of Human Muscle α-Actinin.

Cell doi:10.1016/j.cell.2014.10.056
Europe PMC | doi

Lamontanara AJ, Georgeon S, Tria G, Svergun DI, Hantschel O. (2014)

The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility.

Nat Commun 5:Article No 5470. doi:10.1038/ncomms6470
Europe PMC | doi

Nilsson OB, Neimert-Andersson T, Bronge M, Grundström J, Sarma R, Uchtenhagen H, Kikhney A, Sandalova T, Holmgren E, Svergun D, Achour A, van Hage M, Grönlund H. (2014)

Designing a multimer allergen for diagnosis and immunotherapy of dog allergic patients.

PLoS ONE 9(10) doi:10.1371/journal.pone.0111041
Europe PMC | doi

Petoukhov MV, Weissenhorn W, Svergun DI. (2014)

Endophilin-A1 BAR domain interaction with arachidonyl CoA.

Front Mol Biosci 1:20. doi:10.3389/fmolb.2014.00020
Europe PMC | doi

Sachyani D, Dvir M, Strulovich R, Tria G, Tobelaim W, Peretz A, Pongs O, Svergun D, Attali B, Hirsch JA. (2014)

Structural Basis of a Kv7.1 Potassium Channel Gating Module: Studies of the Intracellular C-Terminal Domain in Complex with Calmodulin.

Structure 22(11):1582-1594. doi:10.1016/j.str.2014.07.016
Europe PMC | doi

Kuchkina NV, Morgan DG, Kostopoulou A, Lappas A, Brintakis K, Boris BS, Yuzik-Klimova EY, Stein BD, Svergun DI, Spilotros A, Sulman MG, Nikoshvili LZ, Sulman EM, Shifrina ZB, Bronstein LM. (2014)

Hydrophobic Periphery Tails of Polyphenylenepyridyl Dendrons Control Nanoparticle Formation and Catalytic Properties

CHEM MATER 26(19):5654-5663. doi:10.1021/cm502336n
doi

Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HD, Svergun DI, Zhang Y, Wang JH, Meijers R. (2014)

The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue

Neuron 83(4):839-849. doi:10.1016/j.neuron.2014.07.010
Europe PMC | doi

Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R, Svergun DI, Round A, Oegema K, Dong G. (2014)

Structure of the C. elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases

Structure 22(8):1090-1104. doi:10.1016/j.str.2014.05.009
Europe PMC | doi

Marrott NL, Marshall JJ, Svergun DI, Crennell SJ, Hough DW, van den Elsen JM, Danson MJ. (2014)

Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex.

Biochem. J. 463(3):405-412. doi:10.1042/bj20140359
Europe PMC | doi

Sergeeva O, Vlasov PS, Domnina NS, Bogomolova A, Konarev PV, Svergun DI, Walterova Z, Horsky J, Stepanek P, Filippov SK. (2014)

Novel thermosensitive telechelic PEGs with antioxidant activity: synthesis, molecular properties and conformational behaviour

RSC ADV 4:41763-41771. doi:10.1039/c4ra06978a
doi

Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N. (2014)

A conformational switch in collybistin determines the differentiation of inhibitory postsynapses

EMBO J. 33(18):2113-2133. doi:10.15252/embj.201488143
Europe PMC | doi

Dunne M, Mertens HD, Garefalaki V, Jeffries CM, Thompson A, Lemke EA, Svergun DI, Mayer MJ, Narbad A, Meijers R. (2014)

The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor

PLoS Pathog. 10(7):e1004228. doi:10.1371/journal.ppat.1004228
Europe PMC | doi

Morgan DG, Boris BS, Kuchkina NV, Yuzik-Klimova EY, Sorokina S, Stein BD, Svergun DI, Spilotros A, Kostopoulou A, Lappas A, Shifrina ZB, Bronstein LM. (2014)

Multicore Iron Oxide Mesocrystals Stabilized by Polyphe-nylenepyridyl Dendron and Dendrimer: Role of the Den-dron/Dendrimer Self-assembly

Langmuir 30(28):8543-8550. doi:10.1021/la502409r
Europe PMC | doi

Duelli A, Kiss B, Lundholm I, Bodor A, Petoukhov MV, Svergun DI, Nyitray L, Katona G. (2014)

The C-terminal random coil region tunes the Ca²⁺-binding affinity of S100A4 through conformational activation

PLoS ONE 9(5):e97654. doi:10.1371/journal.pone.0097654
Europe PMC | doi

Bowman A, Hammond CM, Stirling A, Ward R, Shang W, El-Mkami H, Robinson DA, Svergun DI, Norman DG, Owen-Hughes T. (2014)

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution

Nucleic Acids Res. 42(9):6038-6051. doi:10.1093/nar/gku232
Europe PMC | doi

Konarev PV, Kachalova GS, Ryazanova AY, Kubareva EA, Karyagina AS, Bartunik HD, Svergun DI. (2014)

Flexibility of the Linker between the Domains of DNA Methyltransferase SsoII Revealed by Small-Angle X-Ray Scattering: Implications for Transcription Regulation in SsoII Restriction-Modification System

PLoS ONE 9(4):e93453. doi:10.1371/journal.pone.0093453
Europe PMC | doi

Syson K, Stevenson CE, Rashid AM, Saalbach G, Tang M, Tuukkanen A, Svergun DI, Withers SG, Lawson DM, Bornemann S. (2014)

Structural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds α-Maltose 1-Phosphate and Forms a Maltosyl-enzyme Intermediate

Biochemistry 53(15):2494-2504. doi:10.1021/bi500183c
Europe PMC | doi

Tuukkanen AT, Svergun DI. (2014)

Weak protein-ligand interactions studied by small-angle X-ray scattering.

FEBS J. 281(8):1974-1987. doi:10.1111/febs.12772
Europe PMC | doi

Bonanomi M, Mazzucchelli S, D'Urzo A, Nardini M, Konarev PV, Invernizzi G, Svergun DI, Vanoni M, Regonesi ME, Tortora P. (2014)

Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome.

Int. J. Biochem. Cell Biol. 51:58-64. doi:10.1016/j.biocel.2014.03.015
Europe PMC | doi

Malecki PH, Vorgias CE, Petoukhov MV, Svergun DI, Rypniewski W. (2014)

Crystal structures of substrate-bound chitinase from the psychrophilic bacterium Moritella marina and its structure in solution

Acta Crystallogr. D Biol. Crystallogr. 70(Pt 3):676-684. doi:10.1107/s1399004713032264
Europe PMC | doi

Moglianetti M, Ong QK, Reguera J, Harkness KM, Mameli M, Radulescu A, Kohlbrecher J, Jud C, Svergun DI, Stellacci F. (2014)

Scanning tunneling microscopy and small angle neutron scattering study of mixed monolayer protected gold nanoparticles in organic solvents

CHEM SCI 5(3):1232-1240. doi:10.1039/c3sc52595c
doi

Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A. (2014)

Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae

mBio 5(1):e01120-13. doi:10.1128/mBio.01120-13
Europe PMC | doi

De D, Jeong MH, Leem YE, Svergun DI, Wemmer DE, Kang JS, Kim KK, Kim SH. (2014)

Inhibition of master transcription factors in pluripotent cells induces early stage differentiation

Proc. Natl. Acad. Sci. U.S.A. 111(5):1778-1783. doi:10.1073/pnas.1323386111
Europe PMC | doi

Magbanua E, Konarev PV, Svergun DI, Hahn U. (2014)

Exploring RNA oligomerization and ligand binding by fluorescence correlation spectroscopy and small angle X-ray scattering

Methods Mol. Biol. 1086:321-334. doi:10.1007/978-1-62703-667-2_19
Europe PMC | doi

Otrelo-Cardoso AR, da Silva Correia MA, Schwuchow V, Svergun DI, Romão MJ, Leimkühler S, Santos-Silva T. (2014)

Structural data on the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli: SAXS and preliminary X-ray crystallography analysis

Int J Mol Sci 15(2):2223-2236. doi:10.3390/ijms15022223
Europe PMC | doi

Schulte T, Lofling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, Ebel C, Normark S, Svergun D, Henriques-Normark B, Achour A. (2014)

The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold

OPEN BIOL 4(1):130090. doi:10.1098/rsob.130090
Europe PMC | doi

Varadi M, Kosol S, Lebrun P, Valentini E, Blackledge M, Dunker AK, Felli IC, Forman-Kay JD, Kriwacki RW, Pierattelli R, Sussman J, Svergun DI, Uversky VN, Vendruscolo M, Wishart D, Wright PE, Tompa P. (2014)

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins

Nucleic Acids Res. 42(Database issue):D326-D335. doi:10.1093/nar/gkt960
Europe PMC | doi

Wilmanns M, Svergun DI. (2014)

The 11th International Conference on Biology and Synchrotron Radiation

J Synchrotron Radiat 21(Pt 1):280-282. doi:10.1107/s1600577513030609
Europe PMC | doi


2013

Shtykova EV, Kabachii YA, Valetsky PM, Kochev SS, Malyutin AG, Stein BD, Bronstein LM, Svergun DI. (2013)

Solution study of novel diblock copolymers: Morphology and structural transition

POLYMER 54(26):6971-6978. doi:10.1016/j.polymer.2013.10.047
doi

Begum A, Drebes J, Kikhney A, Müller IB, Perbandt M, Svergun D, Wrenger C, Betzel C. (2013)

Staphylococcus aureus thiaminase II: oligomerization warrants proteolytic protection against serine proteases

Acta Crystallogr. D Biol. Crystallogr. 69(Pt 12):2320-2329. doi:10.1107/s0907444913021550
Europe PMC | doi

Filippov SK, Franklin JM, Konarev PV, Chytil P, Etrych T, Bogomolova A, Dyakonova M, Papadakis CM, Radulescu A, Ulbrich K, Stepanek P, Svergun DI. (2013)

Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study

Biomacromolecules 14(11):4061-4070. doi:10.1021/bm401186z
Europe PMC | doi

Svergun DI, Koch MHJ, Timmins PA, May RP. (2013)

Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules

IUCr Monographs on Crystallography. Oxford Univ Pr. doi:10.1093/acprof:oso/9780199639533.001.0001
doi

Cerofolini L, Fields GB, Fragai M, Geraldes CF, Luchinat C, Parigi G, Ravera E, Svergun DI, Teixeira JM. (2013)

Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state

J. Biol. Chem. 288(42):30659-30671. doi:10.1074/jbc.m113.477240
Europe PMC | doi

Giganti D, Alegre-Cebollada J, Urresti S, Albesa-Jové D, Rodrigo-Unzueta A, Comino N, Kachala M, López-Fernández S, Svergun DI, Fernández JM, Guerin ME. (2013)

Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria

J. Biol. Chem. 288(41):29797-29808. doi:10.1074/jbc.m113.462705
Europe PMC | doi

Graewert MA, Svergun DI. (2013)

Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS)

Curr. Opin. Struct. Biol. 23(5):748-754. doi:10.1016/j.sbi.2013.06.007
Europe PMC | doi

Petoukhov MV, Billas IM, Takacs M, Graewert MA, Moras D, Svergun DI. (2013)

Reconstruction of quaternary structure from X-ray scattering by equilibrium mixtures of biological macromolecules

Biochemistry 52(39):6844-6855. doi:10.1021/bi400731u
Europe PMC | doi

Sander B, Tria G, Shkumatov AV, Kim EY, Grossmann JG, Tessmer I, Svergun DI, Schindelin H. (2013)

Structural characterization of gephyrin by AFM and SAXS reveals a mixture of compact and extended states

Acta Crystallogr. D Biol. Crystallogr. 69(Pt 10):2050-2060. doi:10.1107/s0907444913018714
Europe PMC | doi

Groothuizen FS, Fish A, Petoukhov MV, Reumer A, Manelyte L, Winterwerp HH, Marinus MG, Lebbink JH, Svergun DI, Friedhoff P, Sixma TK. (2013)

Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation

Nucleic Acids Res. 41(17):8166-8181. doi:10.1093/nar/gkt582
Europe PMC | doi

Koch C, Tria G, Fielding AJ, Brodhun F, Valerius O, Feussner K, Braus GH, Svergun DI, Bennati M, Feussner I. (2013)

A structural model of PpoA derived from SAXS-analysis-implications for substrate conversion

Biochim. Biophys. Acta 1831(9):1449-1457. doi:10.1016/j.bbalip.2013.06.003
Europe PMC | doi

Dölker N, Blanchet CE, Voß B, Haselbach D, Kappel C, Monecke T, Svergun DI, Stark H, Ficner R, Zachariae U, Grubmüller H, Dickmanns A. (2013)

Structural determinants and mechanism of mammalian CRM1 allostery

Structure 21(8):1350-1360. doi:10.1016/j.str.2013.05.015
Europe PMC | doi

Yan R, Konarev PV, Iannuzzi C, Adinolfi S, Roche B, Kelly G, Simon L, Martin SR, Py B, Barras F, Svergun DI, Pastore A. (2013)

Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS

J. Biol. Chem. 288(34):24777-24787. doi:10.1074/jbc.m113.480327
Europe PMC | doi

Trewhella J, Hendrickson WA, Kleywegt GJ, Sali A, Sato M, Schwede T, Svergun DI, Tainer JA, Westbrook J, Berman HM. (2013)

Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB

Structure 21(6):875-881. doi:10.1016/j.str.2013.04.020
Europe PMC | doi

Felix J, Elegheert J, Gutsche I, Shkumatov AV, Wen Y, Bracke N, Pannecoucke E, Vandenberghe I, Devreese B, Svergun DI, Pauwels E, Vergauwen B, Savvides SN. (2013)

Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor

Structure 21(4):528-539. doi:10.1016/j.str.2013.01.018
Europe PMC | doi

Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M. (2013)

Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid

Nucleic Acids Res. 41(6):3874-3887. doi:10.1093/nar/gkt053
Europe PMC | doi

de Chiara C, Rees M, Menon RP, Pauwels K, Lawrence C, Konarev PV, Svergun DI, Martin SR, Chen YW, Pastore A. (2013)

Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold

Biophys. J. 104(6):1304-1313. doi:10.1016/j.bpj.2013.01.048
Europe PMC | doi

Söderberg CA, Rajan S, Shkumatov AV, Gakh O, Schaefer S, Ahlgren EC, Svergun DI, Isaya G, Al-Karadaghi S. (2013)

The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization

J. Biol. Chem. 288(12):8156-8167. doi:10.1074/jbc.m112.442285
Europe PMC | doi

Mehtälä ML, Haataja TJ, Blanchet CE, Hiltunen JK, Svergun DI, Glumoff T. (2013)

Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering

FEBS Lett. 587(4):305-310. doi:10.1016/j.febslet.2012.12.014
Europe PMC | doi

Petoukhov MV, Svergun DI. (2013)

Applications of small-angle X-ray scattering to biomacromolecular solutions

Int. J. Biochem. Cell Biol. 45(2):429-437. doi:10.1016/j.biocel.2012.10.017
Europe PMC | doi