Location & dates EMBL Hamburg, Germany 7 - 9 Oct 2019
Deadlines Registration closed Abstract submission closed



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Day 1 - Monday 7 October 2019
11:00-12:45 Arrival and Registration with light refreshments
12:45-13:00 Welcome address: Christian Löw, EMBL Hamburg, Germany

Session 1 - Membrane mimetics for biochemistry and biophysics
Franz Hagn, Technical University of Munich, Germany


Structure and Dynamics of Membrane Proteins in Nanodiscs
Ilia G. Denisov - University of Illinois at Urbana-Champaign, USA 


Circularizing a reconstituted nanodisc using a fusion construct
Frederik Tidemand, University of Copenhagen, Denmark


Evolving GPCRs for Enabling Structural and Functional Studies
Andreas Plückthun, University of Zurich, Switzerland


Stabilization of Native Membrane Protein Targets for Drug Discovery
Anass Jawhari - CALIXAR, France


Structure based Drug Design for GPCRs
Jana Broecker - Sosei Heptares, UK 


Coffee break and Meet the Speakers: Ilia G. Densiov, Jana Broecker, Michael Overduin, Yifan Cheng


Session 2 - Structure, dynamics and folding of MP in discs
Ayyalusamy Ramamoorthy, University of Michigan, USA


Converging lipidomics, metabolomics, interactomics and proteomics within native nanodiscs
Michael Overduin - University of Alberta, Canada


Nanodisc insertion affects water mobility at intra-membrane protein hydration sites
Karim Fahmy - Helmholtz-Zentrum Dresden-Rossendorf, Germany


Co-translational f;olding of alpha helical membrane proteins in lipid bilayers
Paula Booth - King's College London, UK 


The mechanism of membrane insertion of the CLIC1 chloride channel
Jose Ortega-Rolden - University of Kent, UK


Covalently circularized nanodiscs for studies of membrane proteins in a stable near-native environment
Gerhard Wagner - Harvard Medical School, USA 

17:30-19:00 Poster session 1 (odd numbers)
19:00-20:00 Dinner
20:00-21:30 Session 3 - Membrane protein structure and biophysics
Christian Löw, EMBL Hamburg, Germany

Small angle X ray scattering to study membrane protein solutions
Haydyn Mertens - EMBL Hamburg, Germany

20:30-20:45 Electron cryo-microscopy structure of the canonical TRPC4 ion channel reveals the binding site for its regulatory proteins
Deivanayagabarathy Vinayagam, Max-Planck Institute for Molecular Pysiology, Germany

Single particle cryo-EM of membrane proteins in lipid nanodiscs
Yifan Cheng - University of California, San Francisco, USA

21:15-23:00 Welcome Reception
Day 2 - Tuesday 8 October 2019

Beamline and Electron Microscopy Facility Tours (optional: limited places available, pre-registration required)


Session 4 - Novel membrane tools for structural biology
Chair: Ilia G. Denisov - University of Illinois at Urbana-Champaign, USA


Shaping bacterial cells with genetics to produce membrane proteins
Bruno Miroux - Institut de Biologie Physico-Chimique, CNRS-Université de Paris, France 


Realtime single-molecule FRET analysis of the conformational cycle of multidrug transporter LmrP
Jelle Hendrix, Hasselt University, Belgium


The Salipro system for membrane proteins: Structures, Antibodies and Direct Extraction
Jens Frauenfeld - Salipro, Sweden


In meso in situ serial crystallography at synchrotron and XFEL
Chia-Ying Huang - Swiss Light Source/PSI, Switzerland


Coffee break and Meet the Speakers: Paula Booth, Bruno Miroux, Gerhard Wagner, Jens Frauenfeld


Session 5 - Scattering methods on membrane proteins
Antoinette Killian - Utrecht University, The Netherlands


New Polymer-Based Nanodiscs for Membrane Biophysics
Sandro Keller - University of Kaiserslautern, Germany


Conformational States of ABC Transporter MsbA in a Lipid Environment Investigated by Small-Angle Scattering Using Stealth Carrier Nanodiscs
Inokentijs Josts - University of Hamburg, Germany


Methods for interpreting small angle scattering scattering data from membrane proteins
Lise Arleth - University of Copenhagen, Denemar


Combining invisible detergents and SEC-SANS to study membrane protein structure in solution
Nicolai Johansen - University of Copenhagen, Denmark




Poster Session 2 (even numbers)


Session 6 - Drug design and function I
Chair: Sandro Keller - University of Kaiserslautern, Germany


Crystal structure of CC chemokine receptor 2A provides insights for the design of selective antagonists
Gisela Schnapp - Boehringer Ingelheim, Germany


Structure of amyloid-ß(1- 42) tetramers and octamers reveal edge conductivity channels as a mechanism for membrane damage
Edward Puig - IRB Barcelona, Spain

15:45 - 16:15

Biophysics platform integration in  LeadXpro’s structure-based drug discovery pipeline
Nicolas Bocquet - leadXpro AG, Switzerland


Gating of a divalent cation channel by 100 kHz magic-angle spinning NMR in lipid bilayers
Marta Bonaccorsi - Centre de RMN à Très Hauts Champs, FRE 2034  CNRS  Lyon, France

16:30-17:00 Coffee break and Meet the Speakers: Sandro Keller, Lise Arleth, Gisela Schnapp, Nicolas Bocquet, Daniel Nietlispach, Russell Bishop

Session 7 - Membrane Protein Structural Biology
Chair: Russell Bishop - McMaster University, Canada

17:00-17:30 Solution NMR studies of membrane proteins embedded in a lipid bilayer using the saposin nanoparticle system
Daniel Nietlispach - University of Cambridge, UK
17:30-17:45 In situ NMR spectroscopy of bacterial outer membrane proteins
Johannes Thoma - University of Gothenburg, Sweden
17:45-18:00 Developing ApoA1 and ApoE4 nanodiscs as a tool for XFEL-based structural biology
Megan Shelby - Lawrence Livermore National Lab, USA

Single particle cryo-EM of membrane proteins
Stefan Raunser - Max-Planck-Institut für molekulare Physiologie, Germany

19:00-22:00 Conference Dinner (DESY bistro/canteen)
Day 3 - Wednesday 9 October 2019
08:15-08:45 Beamline and Electron Microscopy Facility Tours (optional: limited places available, pre-registration required)
09:00-10:30 Session 8 - Production and reconstitution of MPs
Chair: Cristina Paulino - University of Groningen, The Netherlands
09:00-09:30 The use of Styrene Maleic Acid Co-polymer (SMALP) for membrane protein characterisation
Tim Dafforn - University of Birmingham, UK
09:30-09:45 Purification of Mycobacteria tuberculosis ESX-1 inner membrane core complex and its individual subunits
Ye Gao - Maastricht University, The Netherlands
09:45-10:15 Precursor-based selective methyl labelling of cell-free synthesized proteins
Volker Dötsch - Goethe University Frankfurt, Germany
10:15-10:30 Functional reconstitution of the 5-HT3 receptor
Uriel López-Sánchez - CNRS- Institut de Biologie Structurale, France

Coffee break and Meet the Speakers: Tim Dafforn, Volker Dötsch, Tzviya Zeev Ben Mordehai, Cristina Paulino

11:15-12.45 Session 9 - Structure of function of MPs I
Chair: Paula Booth - King's College London, UK
11:15-11:45 Factors influencing the solubilization of membrane proteins by SMA copolymers
Antoinette Killian - Utrecht University, The Netherlands 
11:45-12:00 Structure of SLC4 transporter reveals novel conformational changes for ion transport
Jiansen Jiang - National Institutes of Health (NIH), USA

Membrane protein enriched extracellular vesicles for structural characterisation on native membranes
Tzviya Zeev Ben Mordehai - Utrecht University, The Netherlands 

The ion-transporter NKCC1: characterization of the structure-function relationship
Corinne Portioli -Istituto Italiano di Tecnologia, Italy and Baylor College of Medicine, USA
12.45-13:45 Lunch

Session 10 - Structure of function of MPs II
Chair: Michael Overduin - University of Alberta, Canada

13:45-14:00 Poster Prize Award
14:00-14:30 cryo-EM in lipid nanodiscs:The flips and flops of a scramblase story
Cristina Paulino - University of Groningen, The Netherlands 
14:30-14:45 Functional determinants of a small protein repressor controlling a broadly conserved bacterial sensor kinase
Jing Yuan - Max Planck Institute for Terrestrial Microbiology, Germany
14:45-15:15 The multifunctional enzymology of PagP
Russell Bishop - McMaster University, Canada
15:15-15:30 Final Remarks and Farewell