Rigid body modelling: applications to proteins
Katherine A. Brown
Imperial College London, UK and The University of Texas at Austin, USA
A powerful application involving small-angle X-ray scattering (SAXS) data is the alignment of three-dimensional structures or homology models within the low resolution shapes determined using SAXS. This talk will provide an overview to experimental strategies that have been used to obtain biologically meaningful models of monomeric, oligomeric and multi-protein complexes. Selected examples will be presented to show how these SAXS-derived models have been used to improve the understanding of how proteins fold, assemble, and function.
Date/time: Thursday, 28 October, 12:00