| Thursday, April 28 |
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Basics of macromolecules and SAXS/SANS |
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08:30 - 09:30 |
Zhijie Liu (Introduction to macromolecular structure)
video
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09:30 - 10:30 |
Yuhui Dong (Introduction to Protein Data Bank)
video
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10:30 - 11:00 |
Coffee Break |
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11:00 - 12:00 |
Michel Koch (Basics of X-ray scattering by solutions)
video
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12:00 - 13:00 |
Jill Trewhella (The Basics of Neutron Scattering) |
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13:00 - 14:00 |
Lunch |
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14:00 - 16:00 |
visit the beamlines at the Beijing Synchrotron Radiation Facility |
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16:00 - 18:00 |
poster session |
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18:30 - 21:30 |
Welcome dinner |
| Friday, April 29 |
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Basics of NMR |
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08:30 - 10:30 |
Alexandre Bonvin (Introduction to basic NMR) |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 13:00 |
Lucia Banci (Spectral Assignment and Structure Calculation) |
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13:00 - 14:00 |
Lunch |
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14:00 - 16:00 |
Lucia Banci (Recent Advances in Biomolecular NMR) |
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16:00 - 16:30 |
Coffee Break |
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16:30 - 18:30 |
Hands-on practical on NMR |
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18:30 - 20:00 |
Dinner |
| Saturday, April 30 |
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SAXS/SANS data analysis |
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08:30 - 09:30 |
Jill Trewhella (SAXS and SANS facilities and experimental practice)
video
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09:30 - 10:30 |
Weifeng Shang (SAXS/SANS data processing and overall parameters)
video
|
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10:30 - 11:00 |
Coffee Break |
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11:00 - 12:00 |
Dmitri Svergun (Ab initio methods) |
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13:00 - 14:00 |
Lunch |
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14:00 - 16:00 |
Dmitri Svergun (Principles of rigid body refinement) |
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16:00 - 16:30 |
Coffee Break |
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16:30 - 18:30 |
Hands-on practical on SAXS/SANS data analysis |
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18:30 - 20:00 |
Dinner |
| Sunday, May 1 |
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Biophysical methods |
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08:30 - 10:30 |
Lise Arleth (Light scattering and calorimetry) |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 13:00 |
Olwyn Byron (Analytical ultracentrifugation and hydrodynamic modelling) |
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13:00 - 14:00 |
Lunch |
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14:00 - 16:00 |
Haydyn Mertens (Infrared spectroscopy and circular dichroism)
video
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16:00 - 16:30 |
Coffee Break |
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16:30 - 18:30 |
Maria Vanoni (Kinetic and equilibrium absorbance and fluorescence) |
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18:30 - 20:00 |
Dinner |
| Monday, May 2 |
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Multidisciplinary approaches I |
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08:30 - 10:30 |
Peter Konarev (Joint use of SAXS with MX and EM) |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 13:00 |
Manfred Roessle (Combination of X-ray and neutron scattering) |
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13:00 - 14:00 |
Lunch |
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free afternoon and social event |
| Tuesday, May 3 |
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Mixtures, processes and interactions |
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08:30 - 09:30 |
Michel Koch (Intermolecular interactions studied by solution scattering)
video
|
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09:30 - 10:30 |
Lise Arleth (Microfluidics and lab-on-a-chip systems) |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 12:00 |
Peter Konarev (Quantitative characterization of mixtures and complex formation) |
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12:00 - 13:00 |
Manfred Roessle (Time-resolved SAXS and SANS) |
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13:00 - 14:00 |
Lunch |
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14:00 - 15:00 |
Weifeng Shang (Protein unfolding and flexible systems)
video
|
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15:00 - 16:00 |
hands-on practical on mixtures |
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16:00 - 16:30 |
Coffee Break |
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16:30 - 18:30 |
hands-on practical on flexible systems |
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18:30 - 20:00 |
Dinner |
| Wednesday, May 4 |
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Multidisciplinary approaches II |
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08:30 - 10:30 |
Olwyn Byron (Combination of scattering and biophysical methods) |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 13:00 |
Alexandre Bonvin (NMR and bioinformatics) |
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13:00 - 14:00 |
lunch |
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14:00 - 16:00 |
Haydyn Mertens (Joint application of NMR and scattering) |
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16:00 - 16:30 |
Coffee Break |
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16:30 - 18:30 |
Maria Vanoni (Synergistic use of structural and functional methods) |
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18:30 - 20:00 |
Dinner |
| Thursday, May 5 |
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Public workshop open to local researchers and students |
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09:00 - 09:10 |
Introduction (Dmitri Svergun, Yuhui Dong) |
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Session 1 Multidisciplinary studies of biological macromolecules
Chair: Yuhui Dong |
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09:10 - 09:50 |
Olwyn Byron (Understanding the structure of drug target macromolecules through combined biophysical approaches) |
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09:50 - 10:30 |
Maria Vanoni (Structure-function studies on novel flavoproteins implicated in neurodegeneration and cancer) |
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10:30 - 11:00 |
Coffee Break |
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11:00 - 11:40 |
Alexandre Bonvin (Building macromolecular assemblies by information-driven docking: Challenges and perspectives) |
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11:40 - 12:20 |
Zhijie Liu (The application of combined X-ray crystallography and NMR in studying the protein-protein interaction) |
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12:30 - 13:30 |
lunch |
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Session 2 Selected participants presentations
Chair: Lise Arleth |
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13:30 - 14:30 |
4 talks of 15 minutes |
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Angela Criswell (Identification of protein standards for SAXS measurements) |
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Zhiyong Zhang (Coarse-grained representations of biomolecular machines from low resolution structure data) |
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Eleonora Shtykova (Virus Matrix protein M1: SAXS Data Analysis and Modeling) |
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Tianfu Li (Contrast Variation Small Angle Neutron Scattering Study of PAMAM Dendrimers in Aqueous Solution) |
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Session 3 Structural analysis with synchrotron radiation
Chair: Zhijie Liu |
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14:30 - 15:10 |
Yuhui Dong (The structure research techniques in Beijing Synchrotron Radiation Facility) |
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15:10 - 15:40 |
Coffee Break |
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15:40 - 16:20 |
Dmitri Svergun (Synchrotron small-angle X-ray scattering as a tool for structural systems biology) |
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16:20 - 17:00 |
Lise Arleth (Using phospholipid nanodiscs as a platform for low-resolution structural studies of membrane proteins) |
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Session 4 EMBL collaborative studies
Chair: Olwyn Byron |
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17:00 - 18:30 |
4 talks of 20 minutes |
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Weifeng Shang (SAXS investigations on mammalian lipoxygenases) |
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Haydyn Mertens (Exploring components of the innate immune system in a combined SAXS, NMR and crystallography approach) |
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Peter Konarev (SAXS and ITC studies of nucleoplasmin and its complexes with histones and importins) |
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Manfred Roessle (SAXS on working proteins - ATPase Synthases) |
