Using SAXS to study DNA regulation

Titia K. Sixma

DNA repair processes are intricately regulated. We study the molecular machinery involved in DNA regulation using a combination of structural biology and biochemical analysis. In this lecture examples will be discussed on initial steps in the process of DNA mismatch repair and enzyme regulation in ubiquitin conjugation. SAXS analysis has given insights into conformational states in ubiquitin conjugating and deconjugating enzymes as well as the ubiquitinated target. Together with structural biology and biochemical analysis this has helped us gain new insights in these essential processes.

Date/time: Saturday, 1 November 2014, 15:30